Standard name Systematic name Name description Description
HLJ1 YMR161W Co-chaperone for Hsp40p Co-chaperone for Hsp40p; anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ
Visualize the interactome of HLJ1
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.697 0.692 0.812
ER 0.288 0.115 0.125
Endosome NaN 0.077 NaN
Vac/Vac Memb NaN 0.077 NaN
Mito NaN NaN 0.125

GFP localization & abundance

GFP localization GFP abundance
ER 1840

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
HLJ1 2 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SSH1 YBR283C Subunit of the Ssh1 translocon complex genetic 7 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Negative Genetic
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 7 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Suppression, Phenotypic Suppression, Negative Genetic
TRS85 YDR108W Component of transport protein particle (TRAPP) complex III genetic 6 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PHO80 YOL001W Cyclin genetic 5 2 3 Negative Genetic, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SLP1 YOR154W Glycosylated integral ER membrane protein of unknown function genetic 3 1 2 Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 2 2 2 Phenotypic Suppression, Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
AAD4 YDL243C Putative aryl-alcohol dehydrogenase genetic 2 1 2 Negative Genetic, Negative Genetic
AIM34 YMR003W Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
SRP101 YDR292C Signal recognition particle (SRP) receptor alpha subunit genetic 2 1 2 Negative Genetic, Negative Genetic
VMA8 YEL051W Subunit D of the V1 peripheral membrane domain of V-ATPase genetic 2 1 2 Positive Genetic, Positive Genetic
NEO1 YIL048W Phospholipid translocase (flippase) genetic 2 1 2 Negative Genetic, Negative Genetic
HRI1 YLR301W Protein of unknown function that interacts with Sec72p and Hrr25p genetic 2 1 2 Negative Genetic, Negative Genetic
SEC61 YLR378C Conserved ER protein translocation channel genetic 2 1 2 Negative Genetic, Negative Genetic
PYC2 YBR218C Pyruvate carboxylase isoform genetic 2 1 2 Negative Genetic, Negative Genetic
NDE2 YDL085W Mitochondrial external NADH dehydrogenase genetic 2 1 2 Negative Genetic, Negative Genetic
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 2 1 2 Negative Genetic, Negative Genetic
NKP2 YLR315W Central kinetochore protein and subunit of the Ctf19 complex genetic 2 1 2 Negative Genetic, Negative Genetic
MKS1 YNL076W Pleiotropic negative transcriptional regulator genetic 2 1 2 Negative Genetic, Negative Genetic
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex genetic 2 1 2 Negative Genetic, Negative Genetic
FMT1 YBL013W Methionyl-tRNA formyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
CKA2 YOR061W Alpha' catalytic subunit of casein kinase 2 (CK2) genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
ARC18 YLR370C Subunit of the ARP2/3 complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
EDE1 YBL047C Scaffold protein involved in the formation of early endocytic sites genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
GLO3 YER122C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
ERV25 YML012W Member of the p24 family involved in ER to Golgi transport genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 2 1 1 Negative Genetic, Negative Genetic
DOA4 YDR069C Ubiquitin hydrolase genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
DRS2 YAL026C Trans-golgi network aminophospholipid translocase (flippase) genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
ARF1 YDL192W ADP-ribosylation factor genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
CYS3 YAL012W Cystathionine gamma-lyase genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
GTR1 YML121W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
BRE5 YNR051C Ubiquitin protease cofactor genetic 2 1 1 Negative Genetic, Negative Genetic
EMC1 YCL045C Member of conserved endoplasmic reticulum membrane complex genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
EMC5 YIL027C Member of conserved ER transmembrane complex genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
EMC6 YLL014W Member of conserved ER transmembrane complex genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
CUE1 YMR264W Ubiquitin-binding protein genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
BST1 YFL025C GPI inositol deacylase of the endoplasmic reticulum (ER) genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
EMC4 YGL231C Member of conserved ER transmembrane complex genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
ROT1 YMR200W Molecular chaperone involved in protein folding in ER genetic 2 1 1 Negative Genetic, Negative Genetic
SPF1 YEL031W P-type ATPase, ion transporter of the ER membrane genetic 2 1 1 Negative Genetic, Negative Genetic
YCT1 YLL055W High-affinity cysteine-specific transporter genetic 2 1 1 Positive Genetic, Positive Genetic
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 2 1 1 Positive Genetic, Positive Genetic
RAD61 YDR014W Subunit of a complex that inhibits sister chromatid cohesion genetic 2 1 1 Negative Genetic, Negative Genetic
SIP4 YJL089W C6 zinc cluster transcriptional activator genetic 2 1 1 Negative Genetic, Negative Genetic
SST2 YLR452C GTPase-activating protein for Gpa1p genetic 2 1 1 Negative Genetic, Negative Genetic
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain genetic 2 1 1 Negative Genetic, Negative Genetic
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
PMT2 YAL023C Protein O-mannosyltransferase of the ER membrane genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
NHX1 YDR456W Na+/H+ and K+/H+ exchanger genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
LAS21 YJL062W Mannose-ethanolamine phosphotransferase genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
VPS52 YDR484W Component of the GARP (Golgi-associated retrograde protein) complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
VPS3 YDR495C Component of CORVET membrane tethering complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
VPS38 YLR360W Part of a Vps34p phosphatidylinositol 3-kinase complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
ILM1 YJR118C Protein of unknown function genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
VPS9 YML097C Guanine nucleotide exchange factor (GEF) and ubiquitin receptor genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SPT4 YGR063C Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
LHS1 YKL073W Molecular chaperone of the endoplasmic reticulum lumen genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
MEH1 YKR007W Subunit of the EGO/GSE complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
PER1 YCR044C Protein of the endoplasmic reticulum genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
STP22 YCL008C Component of the ESCRT-I complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
KIN3 YAR018C Nonessential serine/threonine protein kinase genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
VPS28 YPL065W Component of the ESCRT-I complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
VPS54 YDR027C Component of the GARP (Golgi-associated retrograde protein) complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SBH2 YER019C-A Ssh1p-Sss1p-Sbh2p complex component genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
UBX4 YMR067C UBX domain-containing protein that interacts with Cdc48p genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
SSM4 YIL030C Membrane-embedded ubiquitin-protein ligase and retrotranslocase genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
UBC7 YMR022W Ubiquitin conjugating enzyme genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
EMC3 YKL207W Member of conserved ER transmembrane complex genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
EMC2 YJR088C Member of conserved ER transmembrane complex genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
EMP65 YER140W Integral membrane protein of the ER genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
APQ12 YIL040W Nuclear envelope/ER integral membrane protein genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MSN2 YMR037C Stress-responsive transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT7 YBR081C Subunit of the SAGA transcriptional regulatory complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UGA3 YDL170W Transcriptional activator for GABA-dependent induction of GABA genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
APC1 YNL172W Largest subunit of the Anaphase-Promoting Complex/Cyclosome genetic 1 1 1 Negative Genetic
HIS3 YOR202W Imidazoleglycerol-phosphate dehydratase genetic 1 1 1 Phenotypic Suppression
BRE2 YLR015W Subunit of COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
GPI16 YHR188C Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Negative Genetic
CST6 YIL036W Basic leucine zipper (bZIP) transcription factor from ATF/CREB family genetic 1 1 1 Positive Genetic
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-RNA
APD1 YBR151W 2Fe-2S cytosolic protein of unknown function genetic 1 1 1 Negative Genetic
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
EOS1 YNL080C Protein involved in N-glycosylation genetic 1 1 1 Phenotypic Suppression
CDC50 YCR094W Endosomal protein that interacts with phospholipid flippase Drs2p genetic 1 1 1 Negative Genetic
RAD30 YDR419W DNA polymerase eta physical 1 1 1 PCA
SNQ2 YDR011W Plasma membrane ATP-binding cassette (ABC) transporter physical 1 1 1 PCA
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
PSG1 YKL077W Protein that promotes the transport and maturation of Pma1 with Exp1 physical 1 1 1 Affinity Capture-MS
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-RNA
PUB1 YNL016W Poly (A)+ RNA-binding protein physical 1 1 1 Affinity Capture-MS
YPK1 YKL126W S/T protein kinase genetic 1 1 1 Dosage Rescue
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Growth Defect
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 1 1 1 Negative Genetic
RPO41 YFL036W Mitochondrial RNA polymerase genetic 1 1 1 Negative Genetic
YPS5 YGL259W Protein with similarity to GPI-anchored aspartic proteases genetic 1 1 1 Negative Genetic
SHE2 YKL130C RNA-binding protein that binds specific mRNAs and interacts with She3p genetic 1 1 1 Negative Genetic
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 1 1 1 Negative Genetic
KAR2 YJL034W ATPase involved in protein import into the ER genetic 1 1 1 Positive Genetic
YPL068C YPL068C Protein of unknown function genetic 1 1 1 Phenotypic Suppression
HOF1 YMR032W F-BAR protein that regulates actin cytoskeleton organization genetic 1 1 1 Positive Genetic
SAR1 YPL218W ARF family GTPase genetic 1 1 1 Phenotypic Suppression
SEC12 YNR026C Guanine nucleotide exchange factor (GEF) genetic 1 1 1 Phenotypic Suppression
YOR1 YGR281W Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Positive Genetic
IZH2 YOL002C Plasma membrane receptor for plant antifungal osmotin genetic 1 1 1 Synthetic Growth Defect
PMI40 YER003C Mannose-6-phosphate isomerase genetic 1 1 1 Positive Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Positive Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Positive Genetic
STB5 YHR178W Transcription factor genetic 1 1 1 Positive Genetic
VMA13 YPR036W Subunit H of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Positive Genetic
TRS20 YBR254C Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Negative Genetic
KOG1 YHR186C Subunit of TORC1 genetic 1 1 1 Negative Genetic
SRP102 YKL154W Signal recognition particle (SRP) receptor beta subunit genetic 1 1 1 Negative Genetic
STT4 YLR305C Phosphatidylinositol-4-kinase genetic 1 1 1 Negative Genetic
SEC65 YML105C Subunit of the signal recognition particle (SRP) genetic 1 1 1 Negative Genetic
SEC62 YPL094C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
HOS2 YGL194C Histone deacetylase and subunit of Set3 and Rpd3L complexes genetic 1 1 1 Negative Genetic
TPK3 YKL166C cAMP-dependent protein kinase catalytic subunit genetic 1 1 1 Negative Genetic
SEA4 YBL104C Subunit of SEACAT, a subcomplex of the SEA complex genetic 1 1 1 Negative Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Negative Genetic
MAF1 YDR005C Highly conserved negative regulator of RNA polymerase III genetic 1 1 1 Negative Genetic
PAA1 YDR071C Polyamine acetyltransferase genetic 1 1 1 Negative Genetic
SKN7 YHR206W Nuclear response regulator and transcription factor genetic 1 1 1 Negative Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Negative Genetic
RPS0B YLR048W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 1 1 1 Negative Genetic
PRM6 YML047C Potassium transporter that mediates K+ influx genetic 1 1 1 Negative Genetic
RUD3 YOR216C Golgi matrix protein genetic 1 1 1 Negative Genetic
PMA2 YPL036W Plasma membrane H+-ATPase genetic 1 1 1 Negative Genetic
MRX11 YPL041C Protein that associates with mitochondrial ribosome genetic 1 1 1 Negative Genetic
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Negative Genetic
BRR6 YGL247W Essential nuclear envelope integral membrane protein genetic 1 1 1 Positive Genetic