Standard name Systematic name Name description Description
HIS3 YOR202W Imidazoleglycerol-phosphate dehydratase Imidazoleglycerol-phosphate dehydratase; catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p
Visualize the interactome of HIS3
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data 2100

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
HIS3 2 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0564 (imidazoleglycerol-phosphate dehydratase)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 2 1 2 DNA to cDNA expression microarray evidence, DNA to cDNA expression microarray evidence
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein regulation 1 1 1 DNA to cDNA expression microarray evidence
GCN4 YEL009C bZIP transcriptional activator of amino acid biosynthetic genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
DSN1 YIR010W Essential component of the outer kinetochore MIND complex physical 1 1 1 Affinity Capture-MS
FRT2 YAL028W Tail-anchored ER membrane protein of unknown function genetic 1 1 1 Dosage Rescue
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
ECM16 YMR128W Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP physical 1 1 1 Affinity Capture-MS
CDC14 YFR028C Protein phosphatase required for mitotic exit physical 1 1 1 Affinity Capture-MS
TIF6 YPR016C Constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
HIS3 YOR202W Imidazoleglycerol-phosphate dehydratase physical 1 1 1 Two-hybrid
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily physical 1 1 1 Affinity Capture-RNA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
RCK2 YLR248W Protein kinase involved in response to oxidative and osmotic stress physical 1 1 1 Affinity Capture-MS
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER physical 1 1 1 Affinity Capture-MS
SND3 YBR106W Involved in SRP-independent protein targeting to the ER physical 1 1 1 Affinity Capture-MS
RPO21 YDL140C RNA polymerase II largest subunit B220 physical 1 1 1 Affinity Capture-MS
HLJ1 YMR161W Co-chaperone for Hsp40p genetic 1 1 1 Phenotypic Suppression
PEF1 YGR058W Penta-EF-hand protein genetic 1 1 1 Phenotypic Suppression
SKY1 YMR216C SR protein kinase (SRPK) genetic 1 1 1 Phenotypic Suppression
VPS51 YKR020W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Phenotypic Suppression
VTC4 YJL012C Vacuolar membrane polyphosphate polymerase genetic 1 1 1 Phenotypic Suppression
LCL2 YLR104W Putative protein of unknown function genetic 1 1 1 Phenotypic Suppression
MPD1 YOR288C Member of the protein disulfide isomerase (PDI) family genetic 1 1 1 Phenotypic Enhancement
NEM1 YHR004C Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme genetic 1 1 1 Phenotypic Enhancement
SSM4 YIL030C Membrane-embedded ubiquitin-protein ligase and retrotranslocase genetic 1 1 1 Phenotypic Enhancement
TED1 YIL039W GPI-glycan remodelase genetic 1 1 1 Phenotypic Enhancement
UBC7 YMR022W Ubiquitin conjugating enzyme genetic 1 1 1 Phenotypic Enhancement
UBX4 YMR067C UBX domain-containing protein that interacts with Cdc48p genetic 1 1 1 Phenotypic Enhancement
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Phenotypic Enhancement
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Phenotypic Enhancement
SLP1 YOR154W Glycosylated integral ER membrane protein of unknown function genetic 1 1 1 Phenotypic Enhancement
KIN3 YAR018C Nonessential serine/threonine protein kinase genetic 1 1 1 Phenotypic Suppression
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Synthetic Lethality
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 1 1 1 Synthetic Rescue
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Negative Genetic
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease genetic 1 1 1 Synthetic Growth Defect
HHF1 YBR009C Histone H4 physical 1 1 1 Affinity Capture-MS
HHF2 YNL030W Histone H4 physical 1 1 1 Affinity Capture-MS
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control physical 1 1 1 Affinity Capture-MS
DOA4 YDR069C Ubiquitin hydrolase genetic 1 1 1 Phenotypic Suppression
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-MS
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation physical 1 1 1 Affinity Capture-MS
HHT1 YBR010W Histone H3 physical 1 1 1 Affinity Capture-MS
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 1 1 1 Phenotypic Suppression
CYS3 YAL012W Cystathionine gamma-lyase genetic 1 1 1 Phenotypic Suppression
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family genetic 1 1 1 Synthetic Growth Defect
ELO3 YLR372W Elongase genetic 1 1 1 Phenotypic Suppression
HHT2 YNL031C Histone H3 physical 1 1 1 Affinity Capture-MS
CUE1 YMR264W Ubiquitin-binding protein genetic 1 1 1 Phenotypic Enhancement
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Dosage Rescue
FRT1 YOR324C Tail-anchored ER membrane protein of unknown function genetic 1 1 1 Dosage Rescue
EMP65 YER140W Integral membrane protein of the ER genetic 1 1 1 Phenotypic Suppression