Standard name Systematic name Name description Description
AIM34 YMR003W Protein of unknown function Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss
Visualize the interactome of AIM34
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
S 75

CYCLoPs localization & abundance

WT1 WT2 WT3
Endosome 0.059 NaN 0.122
Mito 0.919 0.905 0.593
Nuc Periphery 0.052 NaN NaN
ER NaN 0.060 NaN
Vac/Vac Memb NaN 0.063 0.058
Golgi NaN NaN 0.058
Peroxisome NaN NaN 0.185
SpindlePole NaN NaN 0.201

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
AIM34 0 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
FKH1 YIL131C Forkhead family transcription factor regulation 4 3 4 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, ChEC-Seq experiments
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
FKH2 YNL068C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
CHS1 YNL192W Chitin synthase I genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 2 2 2 Synthetic Lethality, Negative Genetic
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 2 1 2 Negative Genetic, Negative Genetic
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex genetic 2 1 2 Negative Genetic, Negative Genetic
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 2 1 2 Negative Genetic, Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 2 1 2 Negative Genetic, Negative Genetic
SPS22 YCL048W Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
PMP3 YDR276C Small plasma membrane protein genetic 2 1 2 Negative Genetic, Negative Genetic
RML2 YEL050C Mitochondrial ribosomal protein of the large subunit (L2) genetic 2 1 2 Negative Genetic, Negative Genetic
SLO1 YER180C-A Protein interacting with Arl3p genetic 2 1 2 Negative Genetic, Negative Genetic
SUT1 YGL162W Zn(II)2Cys6 family transcription factor genetic 2 1 2 Negative Genetic, Negative Genetic
TRS65 YGR166W Component of transport protein particle (TRAPP) complex II genetic 2 1 2 Negative Genetic, Negative Genetic
TDH3 YGR192C Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 3 genetic 2 1 2 Negative Genetic, Negative Genetic
SYG1 YIL047C Plasma membrane protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
FLO11 YIR019C GPI-anchored cell surface glycoprotein (flocculin) genetic 2 1 2 Negative Genetic, Negative Genetic
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 2 1 2 Negative Genetic, Negative Genetic
HOC1 YJR075W Alpha-1,6-mannosyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
HLJ1 YMR161W Co-chaperone for Hsp40p genetic 2 1 2 Negative Genetic, Negative Genetic
OCA2 YNL056W Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
MSH2 YOL090W Protein that binds to DNA mismatches genetic 2 1 2 Negative Genetic, Negative Genetic
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain genetic 2 1 2 Negative Genetic, Negative Genetic
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 2 1 2 Negative Genetic, Negative Genetic
PPT2 YPL148C Phosphopantetheine:protein transferase (PPTase) genetic 2 1 2 Negative Genetic, Negative Genetic
SUT2 YPR009W Zn2Cys6 family transcription factor genetic 2 1 2 Negative Genetic, Negative Genetic
ARV1 YLR242C Cortical ER protein genetic 2 1 2 Negative Genetic, Negative Genetic
TLG2 YOL018C Syntaxin-like t-SNARE genetic 2 1 2 Negative Genetic, Negative Genetic
PTK2 YJR059W Serine/threonine protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HCM1 YCR065W Forkhead transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
ABF2 YMR072W Mitochondrial DNA-binding protein genetic 1 1 1 Negative Genetic
SHE2 YKL130C RNA-binding protein that binds specific mRNAs and interacts with She3p physical 1 1 1 Affinity Capture-RNA
RVS167 YDR388W Calmodulin-binding actin-associated protein physical 1 1 1 Two-hybrid
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Lethality
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Negative Genetic
MED4 YOR174W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MON2 YNL297C Protein with a role in endocytosis and vacuole integrity genetic 1 1 1 Negative Genetic
TDP1 YBR223C Tyrosyl-DNA phosphodiesterase I genetic 1 1 1 Negative Genetic
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin genetic 1 1 1 Negative Genetic
RGP1 YDR137W Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) genetic 1 1 1 Negative Genetic
RSC8 YFR037C Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
PGD1 YGL025C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
PFD1 YJL179W Subunit of heterohexameric prefoldin genetic 1 1 1 Negative Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 1 1 1 Negative Genetic
MED11 YMR112C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RPC11 YDR045C RNA polymerase III subunit C11 genetic 1 1 1 Negative Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes genetic 1 1 1 Negative Genetic
CDC26 YFR036W Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 1 1 1 Negative Genetic
SWD2 YKL018W Subunit of the COMPASS (Set1C) histone H3K4 methyltransferase complex genetic 1 1 1 Negative Genetic
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Negative Genetic
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 1 1 1 Positive Genetic
PRI1 YIR008C Subunit of DNA primase genetic 1 1 1 Positive Genetic
TAF14 YPL129W Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes genetic 1 1 1 Positive Genetic
SEC14 YMR079W Phosphatidylinositol/phosphatidylcholine transfer protein genetic 1 1 1 Synthetic Growth Defect
RPL23A YBL087C Ribosomal 60S subunit protein L23A genetic 1 1 1 Negative Genetic
POP4 YBR257W Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Negative Genetic
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Negative Genetic
SRF1 YDL133W Regulator of phospholipase D (Spo14p) genetic 1 1 1 Negative Genetic
TRM3 YDL112W 2'-O-ribose methyltransferase genetic 1 1 1 Negative Genetic
SSY1 YDR160W Component of the SPS plasma membrane amino acid sensor system genetic 1 1 1 Negative Genetic
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member genetic 1 1 1 Negative Genetic
VMA8 YEL051W Subunit D of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Negative Genetic
COX23 YHR116W Protein that functions in mitochondrial copper homeostasis genetic 1 1 1 Negative Genetic
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
CHS6 YJL099W Member of the ChAPs (Chs5p-Arf1p-binding proteins) family genetic 1 1 1 Negative Genetic
FAR10 YLR238W Protein involved in recovery from arrest in response to pheromone genetic 1 1 1 Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Negative Genetic
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
SPP382 YLR424W Essential protein that forms a dimer with Ntr2p genetic 1 1 1 Negative Genetic
URE2 YNL229C Nitrogen catabolite repression transcriptional regulator genetic 1 1 1 Negative Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 1 1 1 Negative Genetic
PSD1 YNL169C Phosphatidylserine decarboxylase of the mitochondrial inner membrane genetic 1 1 1 Negative Genetic
DFR1 YOR236W Dihydrofolate reductase involved in tetrahydrofolate biosynthesis genetic 1 1 1 Negative Genetic
TOP1 YOL006C Topoisomerase I genetic 1 1 1 Synthetic Growth Defect
TUS1 YLR425W Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity genetic 1 1 1 Synthetic Lethality
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 1 1 1 Dosage Lethality
ILM1 YJR118C Protein of unknown function genetic 1 1 1 Negative Genetic
VPH2 YKL119C Integral membrane protein required for V-ATPase function genetic 1 1 1 Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting genetic 1 1 1 Negative Genetic
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Negative Genetic
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 1 1 1 Negative Genetic
GYP1 YOR070C Cis-golgi GTPase-activating protein (GAP) for yeast Rabs genetic 1 1 1 Negative Genetic
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 1 1 1 Synthetic Growth Defect
TEL2 YGR099W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control genetic 1 1 1 Negative Genetic
DAL2 YIR029W Allantoicase genetic 1 1 1 Positive Genetic
LHS1 YKL073W Molecular chaperone of the endoplasmic reticulum lumen genetic 1 1 1 Positive Genetic
YJR084W YJR084W Protein that forms a complex with Thp3p genetic 1 1 1 Positive Genetic
XDJ1 YLR090W Chaperone with a role in facilitating mitochondrial protein import genetic 1 1 1 Positive Genetic
CMD1 YBR109C Calmodulin genetic 1 1 1 Negative Genetic
ALG1 YBR110W Mannosyltransferase genetic 1 1 1 Negative Genetic
ARP2 YDL029W Essential component of the Arp2/3 complex genetic 1 1 1 Negative Genetic
DBP10 YDL031W Putative ATP-dependent RNA helicase of the DEAD-box protein family genetic 1 1 1 Negative Genetic
CDC9 YDL164C DNA ligase I found in nucleus and mitochondria genetic 1 1 1 Negative Genetic
LCB2 YDR062W Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
SLY1 YDR189W Hydrophilic protein involved in ER/Golgi vesicle trafficking genetic 1 1 1 Negative Genetic
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer genetic 1 1 1 Negative Genetic
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Negative Genetic
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
GPI17 YDR434W Transmembrane protein genetic 1 1 1 Negative Genetic
CCA1 YER168C ATP (CTP):tRNA-specific tRNA nucleotidyltransferase genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
ALG13 YGL047W Catalytic component of UDP-GlcNAc transferase genetic 1 1 1 Negative Genetic
ALG2 YGL065C Mannosyltransferase in the N-linked glycosylation pathway genetic 1 1 1 Negative Genetic
HSF1 YGL073W Trimeric heat shock transcription factor genetic 1 1 1 Negative Genetic
CAB4 YGR277C Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) genetic 1 1 1 Negative Genetic
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
GPI16 YHR188C Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Negative Genetic
RPB3 YIL021W RNA polymerase II third largest subunit B44 genetic 1 1 1 Negative Genetic
GWT1 YJL091C Protein involved in the inositol acylation of GlcN-PI genetic 1 1 1 Negative Genetic
FIP1 YJR093C Subunit of cleavage polyadenylation factor (CPF) genetic 1 1 1 Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
ERG27 YLR100W 3-keto sterol reductase genetic 1 1 1 Negative Genetic
GAB1 YLR459W Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Negative Genetic
GPI15 YNL038W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
LAS17 YOR181W Actin assembly factor genetic 1 1 1 Negative Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
PRP46 YPL151C Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
FLO1 YAR050W Lectin-like protein involved in flocculation genetic 1 1 1 Negative Genetic
EDE1 YBL047C Scaffold protein involved in the formation of early endocytic sites genetic 1 1 1 Negative Genetic
TRM7 YBR061C 2'-O-ribose methyltransferase genetic 1 1 1 Negative Genetic
YBP1 YBR216C Protein involved in cellular response to oxidative stress genetic 1 1 1 Negative Genetic
SLX1 YBR228W Endonuclease involved in DNA recombination and repair genetic 1 1 1 Negative Genetic
BSD2 YBR290W Heavy metal ion homeostasis protein genetic 1 1 1 Negative Genetic
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SOL2 YCR073W-A Protein with a possible role in tRNA export genetic 1 1 1 Negative Genetic
SFA1 YDL168W Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase genetic 1 1 1 Negative Genetic
YDL180W YDL180W Putative protein of unknown function genetic 1 1 1 Negative Genetic
VPS54 YDR027C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
MRH1 YDR033W Protein that localizes primarily to the plasma membrane genetic 1 1 1 Negative Genetic
MRPL1 YDR116C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
RKM2 YDR198C Ribosomal protein lysine methyltransferase genetic 1 1 1 Negative Genetic
SSD1 YDR293C Translational repressor genetic 1 1 1 Negative Genetic
SHE9 YDR393W Protein required for normal mitochondrial morphology genetic 1 1 1 Negative Genetic
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
VPS52 YDR484W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
QCR7 YDR529C Subunit 7 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Negative Genetic
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
GTA1 YEL043W Protein of unknown function genetic 1 1 1 Negative Genetic
MAK10 YEL053C Non-catalytic subunit of the NatC N-terminal acetyltransferase genetic 1 1 1 Negative Genetic
NPR2 YEL062W Subunit of the Iml1p/SEACIT complex genetic 1 1 1 Negative Genetic
PET117 YER058W Assembly factor that couples heme a synthesis to complex IV assembly genetic 1 1 1 Negative Genetic
YER152C YER152C Protein with 2-aminoadipate transaminase activity genetic 1 1 1 Negative Genetic
FET5 YFL041W Multicopper oxidase genetic 1 1 1 Negative Genetic
YFH7 YFR007W Putative kinase with similarity to the PRK/URK/PANK kinase subfamily genetic 1 1 1 Negative Genetic
GET1 YGL020C Subunit of the GET complex genetic 1 1 1 Negative Genetic
VPS45 YGL095C Protein of the Sec1p/Munc-18 family genetic 1 1 1 Negative Genetic
MDM34 YGL219C Mitochondrial component of the ERMES complex genetic 1 1 1 Negative Genetic
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 1 1 1 Negative Genetic
CTT1 YGR088W Cytosolic catalase T genetic 1 1 1 Negative Genetic
COQ6 YGR255C Flavin-dependent monooxygenase involved in ubiquinone biosynthesis genetic 1 1 1 Negative Genetic
ETP1 YHL010C Protein of unknown function required for growth on ethanol genetic 1 1 1 Negative Genetic
YHL012W YHL012W Putative UTP glucose-1-phosphate uridylyltransferase genetic 1 1 1 Negative Genetic
CBP2 YHL038C Required for splicing of the group I intron bI5 of the COB pre-mRNA genetic 1 1 1 Negative Genetic
GVP36 YIL041W BAR domain protein that localizes to early and late Golgi vesicles genetic 1 1 1 Negative Genetic
MRS1 YIR021W Splicing protein genetic 1 1 1 Negative Genetic
COX16 YJL003W Mitochondrial inner membrane protein genetic 1 1 1 Negative Genetic
PEP8 YJL053W Vacuolar protein component of the retromer genetic 1 1 1 Negative Genetic
YJR011C YJR011C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YJR151W-A YJR151W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Negative Genetic
NNR2 YKL151C Widely-conserved NADHX dehydratase genetic 1 1 1 Negative Genetic
EMC3 YKL207W Member of conserved ER transmembrane complex genetic 1 1 1 Negative Genetic
YLL058W YLL058W Putative protein of unknown function with similarity to Str2p genetic 1 1 1 Negative Genetic
YLR126C YLR126C Putative glutamine amidotransferase genetic 1 1 1 Negative Genetic
MET22 YOL064C Bisphosphate-3'-nucleotidase genetic 1 1 1 Negative Genetic
KAR3 YPR141C Minus-end-directed microtubule motor genetic 1 1 1 Negative Genetic
ZDS1 YMR273C Protein with a role in regulating Swe1p-dependent polarized growth genetic 1 1 1 Negative Genetic
TEX1 YNL253W Protein involved in mRNA export genetic 1 1 1 Negative Genetic
ERG24 YNL280C C-14 sterol reductase genetic 1 1 1 Negative Genetic
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Positive Genetic
MPP6 YNR024W Nuclear exosome-associated RNA binding protein genetic 1 1 1 Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
MDM12 YOL009C Mitochondrial outer membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
GSH2 YOL049W Glutathione synthetase genetic 1 1 1 Negative Genetic
FRE7 YOL152W Putative ferric reductase with similarity to Fre2p genetic 1 1 1 Negative Genetic
VAM10 YOR068C Protein involved in vacuole morphogenesis genetic 1 1 1 Negative Genetic
VPS17 YOR132W Subunit of the membrane-associated retromer complex genetic 1 1 1 Negative Genetic
GNT1 YOR320C N-acetylglucosaminyltransferase genetic 1 1 1 Negative Genetic
SPO19 YPL130W Meiosis-specific prospore protein genetic 1 1 1 Negative Genetic
YPL277C YPL277C Putative protein of unknown function genetic 1 1 1 Negative Genetic
SPO24 YPR036W-A Small (67 amino acids) protein involved in sporulation genetic 1 1 1 Negative Genetic
BRR1 YPR057W snRNP protein component of spliceosomal snRNPs genetic 1 1 1 Negative Genetic
MAY24 YPR153W Peripheral ER membrane protein genetic 1 1 1 Negative Genetic
CRD1 YDL142C Cardiolipin synthase genetic 1 1 1 Synthetic Lethality
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 1 1 1 Synthetic Lethality
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Growth Defect