| KES1 |
YPL145C |
Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger |
genetic |
17 |
3 |
14 |
Synthetic Rescue, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue |
| CKI1 |
YLR133W |
Choline kinase |
genetic |
10 |
5 |
9 |
Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Rescue, Synthetic Lethality, Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Enhancement |
| SPO14 |
YKR031C |
Phospholipase D |
genetic |
9 |
3 |
8 |
Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Phenotypic Suppression |
| CSR1 |
YLR380W |
Phosphatidylinositol transfer protein |
genetic |
7 |
3 |
7 |
Dosage Rescue, Dosage Rescue, Synthetic Lethality, Dosage Rescue, Phenotypic Suppression, Dosage Rescue, Dosage Rescue |
| PDR17 |
YNL264C |
Phosphatidylinositol transfer protein (PITP) |
genetic |
6 |
1 |
6 |
Dosage Rescue, Dosage Rescue, Dosage Rescue, Dosage Rescue, Dosage Rescue, Dosage Rescue |
| PCT1 |
YGR202C |
Cholinephosphate cytidylyltransferase |
genetic |
6 |
2 |
5 |
Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue |
| TLG2 |
YOL018C |
Syntaxin-like t-SNARE |
genetic |
6 |
4 |
4 |
Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
| VPS1 |
YKR001C |
Dynamin-like GTPase required for vacuolar sorting |
genetic |
5 |
5 |
5 |
Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement, Dosage Rescue, Positive Genetic |
| GAS1 |
YMR307W |
Beta-1,3-glucanosyltransferase required for cell wall assembly |
genetic |
5 |
3 |
5 |
Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| GYP1 |
YOR070C |
Cis-golgi GTPase-activating protein (GAP) for yeast Rabs |
genetic |
5 |
3 |
5 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| SFH5 |
YJL145W |
Unusual phosphatidylinositol transfer protein (PITP) that binds heme |
genetic |
5 |
3 |
5 |
Dosage Rescue, Synthetic Lethality, Phenotypic Suppression, Dosage Rescue, Dosage Rescue |
| YPT31 |
YER031C |
Rab family GTPase |
genetic |
5 |
3 |
3 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
| FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
4 |
3 |
4 |
chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, chromatin immunoprecipitation- exonuclease evidence, ChEC-Seq experiments |
| ARL3 |
YPL051W |
ARF-like small GTPase of the RAS superfamily |
genetic |
4 |
3 |
4 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
| PTC7 |
YHR076W |
Type 2C serine/threonine protein phosphatase (PP2C) |
physical |
4 |
2 |
4 |
Affinity Capture-MS, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS |
| EAF7 |
YNL136W |
Subunit of the NuA4 histone acetyltransferase complex |
genetic |
4 |
2 |
4 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect |
| SAC1 |
YKL212W |
Phosphatidylinositol phosphate phosphatase |
genetic |
4 |
1 |
4 |
Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue |
| GCS1 |
YDL226C |
ADP-ribosylation factor GTPase activating protein (ARF GAP) |
genetic |
4 |
3 |
3 |
Synthetic Lethality, Synthetic Lethality, Synthetic Rescue, Dosage Rescue |
| TRS85 |
YDR108W |
Component of transport protein particle (TRAPP) complex III |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect |
| TRS33 |
YOR115C |
Core component of TRAPP complexes I, II and IV |
genetic |
4 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect |
| ARL1 |
YBR164C |
Soluble GTPase with a role in regulation of membrane traffic |
genetic |
3 |
3 |
3 |
Synthetic Lethality, Synthetic Growth Defect, Negative Genetic |
| ARF1 |
YDL192W |
ADP-ribosylation factor |
genetic |
3 |
3 |
3 |
Synthetic Rescue, Synthetic Growth Defect, Negative Genetic |
| CRN1 |
YLR429W |
Coronin |
genetic |
3 |
2 |
3 |
Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality |
| SNC2 |
YOR327C |
Vesicle membrane receptor protein (v-SNARE) |
genetic |
3 |
2 |
3 |
Synthetic Growth Defect, Dosage Rescue, Dosage Rescue |
| ERG3 |
YLR056W |
C-5 sterol desaturase |
genetic |
3 |
2 |
3 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| PSD1 |
YNL169C |
Phosphatidylserine decarboxylase of the mitochondrial inner membrane |
genetic |
3 |
2 |
3 |
Negative Genetic, Negative Genetic, Dosage Rescue |
| EAF1 |
YDR359C |
Component of the NuA4 histone acetyltransferase complex |
genetic |
3 |
2 |
2 |
Synthetic Growth Defect, Synthetic Rescue, Synthetic Growth Defect |
| TRS65 |
YGR166W |
Component of transport protein particle (TRAPP) complex II |
genetic |
3 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect |
| RIC1 |
YLR039C |
Protein involved in retrograde transport to the cis-Golgi network |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Positive Genetic |
| CDC42 |
YLR229C |
Small rho-like GTPase |
genetic |
2 |
2 |
2 |
Dosage Rescue, Negative Genetic |
| GIM3 |
YNL153C |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Synthetic Lethality |
| GIM5 |
YML094W |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Synthetic Lethality |
| PAC10 |
YGR078C |
Part of the heteromeric co-chaperone GimC/prefoldin complex |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Synthetic Lethality |
| NUM1 |
YDR150W |
Protein required for nuclear migration |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Synthetic Lethality |
| ROM2 |
YLR371W |
Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
| BUD7 |
YOR299W |
Member of the ChAPs family (Chs5p-Arf1p-binding proteins) |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Synthetic Lethality |
| BEM4 |
YPL161C |
Protein involved in establishment of cell polarity and bud emergence |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Synthetic Lethality |
| BRE5 |
YNR051C |
Ubiquitin protease cofactor |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
| RCY1 |
YJL204C |
F-box protein involved in recycling endocytosed proteins |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Positive Genetic |
| CLA4 |
YNL298W |
Cdc42p-activated signal transducing kinase |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Dosage Rescue |
| KEX2 |
YNL238W |
Kexin, a subtilisin-like protease (proprotein convertase) |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
| BUD23 |
YCR047C |
Ribosome biogenesis factor |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Synthetic Lethality |
| YPT1 |
YFL038C |
Rab family GTPase |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Dosage Rescue |
| VPS51 |
YKR020W |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
| SMI1 |
YGR229C |
Protein involved in the regulation of cell wall synthesis |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
| YPT6 |
YLR262C |
Rab family GTPase |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Positive Genetic |
| SCT1 |
YBL011W |
Glycerol 3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Dosage Rescue |
| ESA1 |
YOR244W |
Catalytic subunit of the histone acetyltransferase complex (NuA4) |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
| RPN11 |
YFR004W |
Metalloprotease subunit of 19S regulatory particle |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| YKL091C |
YKL091C |
Putative phosphatidylinositol/phosphatidylcholine transfer protein |
genetic |
2 |
1 |
2 |
Dosage Rescue, Dosage Rescue |
| SLG1 |
YOR008C |
Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
| PIK1 |
YNL267W |
Phosphatidylinositol 4-kinase |
genetic |
2 |
1 |
2 |
Dosage Rescue, Dosage Rescue |
| MMM1 |
YLL006W |
ER integral membrane protein, ERMES complex subunit |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SFP1 |
YLR403W |
Regulates transcription of ribosomal protein and biogenesis genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| YAP6 |
YDR259C |
Basic leucine zipper (bZIP) transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| CAD1 |
YDR423C |
AP-1-like basic leucine zipper (bZIP) transcriptional activator |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| MBP1 |
YDL056W |
Transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| RPO21 |
YDL140C |
RNA polymerase II largest subunit B220 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CKA1 |
YIL035C |
Alpha catalytic subunit of casein kinase 2 (CK2) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CKA2 |
YOR061W |
Alpha' catalytic subunit of casein kinase 2 (CK2) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| NSE1 |
YLR007W |
Component of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ARP4 |
YJL081C |
Nuclear actin-related protein involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NOP2 |
YNL061W |
rRNA m5C methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RRP1 |
YDR087C |
Essential evolutionarily conserved nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRP19 |
YLL036C |
Splicing factor associated with the spliceosome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BMH1 |
YER177W |
14-3-3 protein, major isoform |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| NSR1 |
YGR159C |
Nucleolin, nucleolar protein that binds nuclear localization sequences |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| LSM1 |
YJL124C |
Lsm (Like Sm) protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| LSM1 |
YJL124C |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| REI1 |
YBR267W |
Cytoplasmic pre-60S factor |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| RPN1 |
YHR027C |
Non-ATPase base subunit of the 19S RP of the 26S proteasome |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPN10 |
YHR200W |
Proteasome polyubiquitin receptor |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPN7 |
YPR108W |
Essential non-ATPase regulatory subunit of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPT6 |
YGL048C |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRT1 |
YOR361C |
eIF3b subunit of the eukaryotic translation initiation factor 3 (eIF3) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| PUF6 |
YDR496C |
Pumilio-homology domain protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| APL6 |
YGR261C |
Beta3-like subunit of the yeast AP-3 complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| BET2 |
YPR176C |
Beta subunit of Type II geranylgeranyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BMH2 |
YDR099W |
14-3-3 protein, minor isoform |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| EMG1 |
YLR186W |
Methyltransferase for rRNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GGA2 |
YHR108W |
Protein that regulates Arf1p, Arf2p to facilitate Golgi trafficking |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| GLO3 |
YER122C |
ADP-ribosylation factor GTPase activating protein (ARF GAP) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| IPP1 |
YBR011C |
Cytoplasmic inorganic pyrophosphatase (PPase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GEA2 |
YEL022W |
Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LCB2 |
YDR062W |
Component of serine palmitoyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MAK3 |
YPR051W |
Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MCD1 |
YDL003W |
Essential alpha-kleisin subunit of the cohesin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HSC82 |
YMR186W |
Cytoplasmic chaperone of the Hsp90 family |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| HSP82 |
YPL240C |
Hsp90 chaperone |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| NOP14 |
YDL148C |
Nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GPT2 |
YKR067W |
Glycerol-3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| IWR1 |
YDL115C |
RNA polymerase II transport factor, conserved from yeast to humans |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| PUP3 |
YER094C |
Beta 3 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BSP1 |
YPR171W |
Adapter that links synaptojanins to the cortical actin cytoskeleton |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPT5 |
YOR117W |
ATPase of the 19S regulatory particle of the 26S proteasome |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SBP1 |
YHL034C |
Protein that binds eIF4G and has a role in repression of translation |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| ECM30 |
YLR436C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| DRS2 |
YAL026C |
Trans-golgi network aminophospholipid translocase (flippase) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| HYP2 |
YEL034W |
Translation elongation factor eIF-5A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ASA1 |
YPR085C |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RHO5 |
YNL180C |
Non-essential small GTPase of the Rho/Rac family of Ras-like proteins |
physical |
1 |
1 |
1 |
PCA |
| GLC8 |
YMR311C |
Regulatory subunit of protein phosphatase 1 (Glc7p) |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| MNN9 |
YPL050C |
Subunit of Golgi mannosyltransferase complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| ECM33 |
YBR078W |
GPI-anchored protein involved in efficient glucose uptake |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| CLB2 |
YPR119W |
B-type cyclin involved in cell cycle progression |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| HMG2 |
YLR450W |
HMG-CoA reductase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| CLN2 |
YPL256C |
G1 cyclin involved in regulation of the cell cycle |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| CDH1 |
YGL003C |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MMS22 |
YLR320W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| APL4 |
YPR029C |
Gamma-adaptin |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MTQ2 |
YDR140W |
S-adenosylmethionine-dependent methyltransferase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| ARP1 |
YHR129C |
Actin-related protein of the dynactin complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CDC43 |
YGL155W |
Beta subunit of geranylgeranyltransferase type I |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| MCM10 |
YIL150C |
Essential chromatin-associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GNA1 |
YFL017C |
Glucosamine-6-phosphate acetyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IRE1 |
YHR079C |
Serine-threonine kinase and endoribonuclease |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| HSP10 |
YOR020C |
Mitochondrial matrix co-chaperonin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RMD1 |
YDL001W |
Cytoplasmic protein required for sporulation |
physical |
1 |
1 |
1 |
Two-hybrid |
| APC11 |
YDL008W |
Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| COG6 |
YNL041C |
Component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| ELP3 |
YPL086C |
Subunit of Elongator complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPL9A |
YGL147C |
Ribosomal 60S subunit protein L9A |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CBF1 |
YJR060W |
Basic helix-loop-helix (bHLH) protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| CPT1 |
YNL130C |
Cholinephosphotransferase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| CLB5 |
YPR120C |
B-type cyclin involved in DNA replication during S phase |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| ELO2 |
YCR034W |
Fatty acid elongase, involved in sphingolipid biosynthesis |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| ELO3 |
YLR372W |
Elongase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| PEA2 |
YER149C |
Coiled-coil 12S polarisome subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RTG2 |
YGL252C |
Sensor of mitochondrial dysfunction |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SEC1 |
YDR164C |
Sm-like protein involved in docking and fusion of exocytic vesicles |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| GOS1 |
YHL031C |
v-SNARE protein involved in Golgi transport |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PRM8 |
YGL053W |
Pheromone-regulated protein |
physical |
1 |
1 |
1 |
Two-hybrid |
| CSG2 |
YBR036C |
Endoplasmic reticulum membrane protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PCL5 |
YHR071W |
Cyclin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ARK1 |
YNL020C |
Ser/Thr protein kinase |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| OSH3 |
YHR073W |
Member of an oxysterol-binding protein family |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| AZF1 |
YOR113W |
Zinc-finger transcription factor |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| PFY1 |
YOR122C |
Profilin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ERV29 |
YGR284C |
Protein localized to COPII-coated vesicles |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| BSD2 |
YBR290W |
Heavy metal ion homeostasis protein |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| GGA1 |
YDR358W |
Golgi-localized protein with homology to gamma-adaptin |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| RER1 |
YCL001W |
Protein involved in retention of membrane proteins |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| HOC1 |
YJR075W |
Alpha-1,6-mannosyltransferase |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| RPS2 |
YGL123W |
Protein component of the small (40S) subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HAC1 |
YFL031W |
Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| INP51 |
YIL002C |
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RPN4 |
YDL020C |
Transcription factor that stimulates expression of proteasome genes |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| ERG5 |
YMR015C |
C-22 sterol desaturase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| AIM44 |
YPL158C |
Regulator of Cdc42p and Rho1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IDS2 |
YJL146W |
Protein involved in modulation of Ime2p activity during meiosis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AUS1 |
YOR011W |
Plasma membrane sterol transporter of the ATP-binding cassette family |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| FMP27 |
YLR454W |
Protein with structural similarity to lipid transport protein Vps13p |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| HCM1 |
YCR065W |
Forkhead transcription factor |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| BTS1 |
YPL069C |
Geranylgeranyl diphosphate synthase (GGPPS) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MMS1 |
YPR164W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| ERG2 |
YMR202W |
C-8 sterol isomerase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| BAP3 |
YDR046C |
Amino acid permease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD34 |
YDR314C |
Protein involved in nucleotide excision repair (NER) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| CUE3 |
YGL110C |
Subunit of ribosome-associated quality control trigger complex (RQT) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| ATG32 |
YIL146C |
Mitochondrial outer membrane protein required to initiate mitophagy |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CUL3 |
YGR003W |
Ubiquitin-protein ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FIG2 |
YCR089W |
Cell wall adhesin, expressed specifically during mating |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| ANR2 |
YKL047W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| RAD27 |
YKL113C |
5' to 3' exonuclease, 5' flap endonuclease |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RTT109 |
YLL002W |
Histone acetyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| YKL091C |
YKL091C |
Putative phosphatidylinositol/phosphatidylcholine transfer protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| YCR007C |
YCR007C |
Putative integral membrane protein |
physical |
1 |
1 |
1 |
Two-hybrid |
| TVP15 |
YDR100W |
Integral membrane protein |
physical |
1 |
1 |
1 |
Two-hybrid |
| SNA3 |
YJL151C |
Protein involved in efficient MVB sorting of proteins to the vacuole |
physical |
1 |
1 |
1 |
Two-hybrid |
| SHO1 |
YER118C |
Transmembrane osmosensor for filamentous growth and HOG pathways |
physical |
1 |
1 |
1 |
Two-hybrid |
| SEC14 |
YMR079W |
Phosphatidylinositol/phosphatidylcholine transfer protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SSB2 |
YNL209W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
1 |
1 |
1 |
Co-purification |
| SPO22 |
YIL073C |
Meiosis-specific protein essential for chromosome synapsis |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SUT1 |
YGL162W |
Zn(II)2Cys6 family transcription factor |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| SEC5 |
YDR166C |
Essential 107kDa subunit of the exocyst complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| SEC15 |
YGL233W |
Essential 113 kDa subunit of the exocyst complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| STE20 |
YHL007C |
Cdc42p-activated signal transducing kinase |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| SEO1 |
YAL067C |
Putative permease |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| TIP1 |
YBR067C |
Major cell wall mannoprotein with possible lipase activity |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| TPM1 |
YNL079C |
Major isoform of tropomyosin |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| SWA2 |
YDR320C |
Auxilin-like protein involved in vesicular transport |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SSD1 |
YDR293C |
Translational repressor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SRF1 |
YDL133W |
Regulator of phospholipase D (Spo14p) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SPE3 |
YPR069C |
Spermidine synthase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| VPS4 |
YPR173C |
AAA-ATPase involved in multivesicular body (MVB) protein sorting |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TRS130 |
YMR218C |
Component of transport protein particle (TRAPP) complex II |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| YCK2 |
YNL154C |
Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| VPS13 |
YLL040C |
Lipid transport protein involved in prospore membrane morphogenesis |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| VPS73 |
YGL104C |
Mitochondrial protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SPR3 |
YGR059W |
Sporulation-specific homolog of the CDC3/10/11/12 family of genes |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SUR1 |
YPL057C |
Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| YDC1 |
YPL087W |
Alkaline dihydroceramidase, involved in sphingolipid metabolism |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SIT4 |
YDL047W |
Ceramide-activated, type 2A-related serine-threonine phosphatase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| ZUO1 |
YGR285C |
Ribosome-associated chaperone |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| UBP3 |
YER151C |
Ubiquitin-specific protease that cleaves Ub-protein fusions |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| TCB2 |
YNL087W |
ER protein involved in ER-plasma membrane tethering |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| WHI2 |
YOR043W |
Negative regulator of TORC1 in response to limiting leucine |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| TUS1 |
YLR425W |
Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| YSA1 |
YBR111C |
Nudix hydrolase family member with ADP-ribose pyrophosphatase activity |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SYS1 |
YJL004C |
Integral membrane protein of the Golgi |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| VPS52 |
YDR484W |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| VPS53 |
YJL029C |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| VPS54 |
YDR027C |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| VPS45 |
YGL095C |
Protein of the Sec1p/Munc-18 family |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SNC1 |
YAL030W |
Vesicle membrane receptor protein (v-SNARE) |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| TBF1 |
YPL128C |
Telobox-containing general regulatory factor |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| YOX1 |
YML027W |
Homeobox transcriptional repressor |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| VAN1 |
YML115C |
Component of the mannan polymerase I |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| YPC1 |
YBR183W |
Alkaline ceramidase |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| XRN1 |
YGL173C |
Evolutionarily-conserved 5'-3' exonuclease |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| UBA4 |
YHR111W |
E1-like protein that activates Urm1p before urmylation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS17 |
YOR132W |
Subunit of the membrane-associated retromer complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SRO7 |
YPR032W |
Effector of Rab GTPase Sec4p |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SSO2 |
YMR183C |
Plasma membrane t-SNARE |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SED5 |
YLR026C |
cis-Golgi t-SNARE syntaxin |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SEC2 |
YNL272C |
Guanyl-nucleotide exchange factor for the small G-protein Sec4p |
genetic |
1 |
1 |
1 |
Positive Genetic |
| VMA8 |
YEL051W |
Subunit D of the V1 peripheral membrane domain of V-ATPase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| UTP5 |
YDR398W |
Subunit of U3-containing Small Subunit (SSU) processome complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| STT3 |
YGL022W |
Catalytic subunit of the oligosaccharyltransferase complex of the ER l |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YHC1 |
YLR298C |
Component of the U1 snRNP complex required for pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SRV2 |
YNL138W |
CAP (cyclase-associated protein) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ULP1 |
YPL020C |
Protease that specifically cleaves Smt3p protein conjugates |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TIF6 |
YPR016C |
Constituent of 66S pre-ribosomal particles |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SSA1 |
YAL005C |
ATPase involved in protein folding and NLS-directed nuclear transport |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TOD6 |
YBL054W |
PAC motif binding protein involved in rRNA and ribosome biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YBR238C |
YBR238C |
Mitochondrial membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS41 |
YDR080W |
Subunit of the HOPS endocytic tethering complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SNX41 |
YDR425W |
Sorting nexin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VAM7 |
YGL212W |
Vacuolar SNARE protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YGL242C |
YGL242C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YLL032C |
YLL032C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SIN3 |
YOL004W |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWI5 |
YDR146C |
Transcription factor that recruits Mediator and Swi/Snf complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YJL136W-A |
YJL136W-A |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPE1 |
YKL184W |
Ornithine decarboxylase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SKY1 |
YMR216C |
SR protein kinase (SRPK) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TUB2 |
YFL037W |
Beta-tubulin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPE2 |
YOL052C |
S-adenosylmethionine decarboxylase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SNF1 |
YDR477W |
AMP-activated S/T protein kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SWH1 |
YAR042W |
Protein similar to mammalian oxysterol-binding protein |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| DNF1 |
YER166W |
Aminophospholipid translocase (flippase) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RPL8A |
YHL033C |
Ribosomal 60S subunit protein L8A |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| RPS19A |
YOL121C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APJ1 |
YNL077W |
Hsp40 chaperone with a role in SUMO-mediated protein degradation |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| OSH7 |
YHR001W |
Oxysterol-binding phosphatidylserine transferase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| OSH6 |
YKR003W |
Oxysterol-binding phosphatidylserine transferase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| ERG4 |
YGL012W |
C-24(28) sterol reductase |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| AIM34 |
YMR003W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SCY1 |
YGL083W |
Putative kinase |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| PIS1 |
YPR113W |
Phosphatidylinositol synthase |
physical |
1 |
1 |
1 |
Two-hybrid |
| KRE1 |
YNL322C |
Cell wall glycoprotein involved in beta-glucan assembly |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MRN1 |
YPL184C |
RNA-binding protein that may be involved in translational regulation |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| CHO1 |
YER026C |
Phosphatidylserine synthase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| RPS25A |
YGR027C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NCS2 |
YNL119W |
Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| NCS6 |
YGL211W |
Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| CDC1 |
YDR182W |
Putative mannose-ethanolamine phosphate phosphodiesterase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DSD1 |
YGL196W |
D-serine dehydratase (aka D-serine ammonia-lyase) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| NHX1 |
YDR456W |
Na+/H+ and K+/H+ exchanger |
genetic |
1 |
1 |
1 |
Positive Genetic |
| DGK1 |
YOR311C |
Diacylglycerol kinase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PER1 |
YCR044C |
Protein of the endoplasmic reticulum |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| HXT8 |
YJL214W |
Protein of unknown function with similarity to hexose transporters |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| PDR16 |
YNL231C |
Phosphatidylinositol transfer protein (PITP) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| PHO3 |
YBR092C |
Constitutively expressed acid phosphatase similar to Pho5p |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ICE2 |
YIL090W |
Integral ER membrane protein with type-III transmembrane domains |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MRX20 |
YFR045W |
Putative mitochondrial transport protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| HPM1 |
YIL110W |
AdoMet-dependent methyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RIM9 |
YMR063W |
Plasma membrane protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RKM3 |
YBR030W |
Ribosomal lysine methyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
