SNC2 |
YOR327C |
Vesicle membrane receptor protein (v-SNARE) |
genetic |
9 |
4 |
9 |
Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
SEC9 |
YGR009C |
t-SNARE protein required for secretory vesicle-plasma membrane fusion |
genetic |
9 |
5 |
8 |
Dosage Rescue, Dosage Rescue, Synthetic Lethality, Synthetic Rescue, Negative Genetic, Synthetic Lethality, Dosage Rescue, Phenotypic Enhancement, Negative Genetic |
SSO1 |
YPL232W |
Plasma membrane t-SNARE |
physical |
8 |
5 |
7 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-crystal Structure, Reconstituted Complex, Two-hybrid, Two-hybrid, Co-fractionation |
SEC9 |
YGR009C |
t-SNARE protein required for secretory vesicle-plasma membrane fusion |
physical |
6 |
3 |
5 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Co-crystal Structure, Affinity Capture-Western |
SSO1 |
YPL232W |
Plasma membrane t-SNARE |
genetic |
3 |
2 |
3 |
Dosage Rescue, Dosage Rescue, Phenotypic Enhancement |
SSO2 |
YMR183C |
Plasma membrane t-SNARE |
physical |
3 |
2 |
3 |
Affinity Capture-Western, Affinity Capture-Western, Co-fractionation |
SSO2 |
YMR183C |
Plasma membrane t-SNARE |
genetic |
3 |
2 |
3 |
Dosage Rescue, Synthetic Lethality, Dosage Rescue |
SNX4 |
YJL036W |
Sorting nexin |
physical |
3 |
2 |
3 |
Affinity Capture-Western, Two-hybrid, Two-hybrid |
MSO1 |
YNR049C |
Lipid-interacting protein in SNARE complex assembly machinery |
physical |
3 |
1 |
3 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
BTN2 |
YGR142W |
v-SNARE binding protein |
physical |
3 |
2 |
2 |
Affinity Capture-Western, Two-hybrid, Affinity Capture-Western |
RCY1 |
YJL204C |
F-box protein involved in recycling endocytosed proteins |
physical |
3 |
2 |
2 |
Affinity Capture-Western, Affinity Capture-Western, PCA |
SWF1 |
YDR126W |
Palmitoyltransferase that acts on transmembrane proteins |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
YIR016W |
YIR016W |
Putative protein of unknown function |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
SEC17 |
YBL050W |
Alpha-SNAP cochaperone |
physical |
2 |
2 |
2 |
Reconstituted Complex, Affinity Capture-Western |
GIS2 |
YNL255C |
Translational activator for mRNAs with internal ribosome entry sites |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Affinity Capture-RNA |
REB1 |
YBR049C |
RNA polymerase I enhancer binding protein |
regulation |
2 |
1 |
2 |
chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence |
DDI1 |
YER143W |
Aspartic-type endopeptidase |
physical |
2 |
1 |
2 |
Affinity Capture-Western, Affinity Capture-Western |
ELO3 |
YLR372W |
Elongase |
genetic |
2 |
1 |
2 |
Synthetic Rescue, Synthetic Rescue |
TOR2 |
YKL203C |
PIK-related protein kinase and rapamycin target |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
ECM8 |
YBR076W |
Non-essential protein of unknown function |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
FAA4 |
YMR246W |
Long chain fatty acyl-CoA synthetase |
genetic |
2 |
2 |
1 |
Dosage Growth Defect, Dosage Rescue |
CYK3 |
YDL117W |
SH3-domain protein located in the bud neck and cytokinetic actin ring |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
RGR1 |
YLR071C |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
CYC8 |
YBR112C |
General transcriptional co-repressor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
MED4 |
YOR174W |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
SUA7 |
YPR086W |
Transcription factor TFIIB |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
GLN3 |
YER040W |
Transcriptional activator in nitrogen catabolite repression system |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
EAF1 |
YDR359C |
Component of the NuA4 histone acetyltransferase complex |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
EAF5 |
YEL018W |
Non-essential subunit of the NuA4 acetyltransferase complex |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
SIT4 |
YDL047W |
Ceramide-activated, type 2A-related serine-threonine phosphatase |
genetic |
1 |
1 |
1 |
Dosage Rescue |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
BEM1 |
YBR200W |
Protein containing SH3-domains |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
AVO1 |
YOL078W |
Component of the membrane-bound TORC2 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
CHC1 |
YGL206C |
Clathrin heavy chain |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
HSC82 |
YMR186W |
Cytoplasmic chaperone of the Hsp90 family |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MTR10 |
YOR160W |
Nuclear import receptor |
genetic |
1 |
1 |
1 |
Negative Genetic |
FAS2 |
YPL231W |
Alpha subunit of fatty acid synthetase |
genetic |
1 |
1 |
1 |
Positive Genetic |
HSP82 |
YPL240C |
Hsp90 chaperone |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SEC17 |
YBL050W |
Alpha-SNAP cochaperone |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SLY1 |
YDR189W |
Hydrophilic protein involved in ER/Golgi vesicle trafficking |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
ATG9 |
YDL149W |
Transmembrane protein involved in forming Cvt and autophagic vesicles |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ARF1 |
YDL192W |
ADP-ribosylation factor |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
SEC18 |
YBR080C |
AAA ATPase and SNARE disassembly chaperone |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
FAA1 |
YOR317W |
Long chain fatty acyl-CoA synthetase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
RAS2 |
YNL098C |
GTP-binding protein |
genetic |
1 |
1 |
1 |
Dosage Rescue |
SEC4 |
YFL005W |
Rab family GTPase |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
BTN2 |
YGR142W |
v-SNARE binding protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
ESS1 |
YJR017C |
Peptidylprolyl-cis/trans-isomerase (PPIase) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PEP12 |
YOR036W |
Target membrane receptor (t-SNARE) |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
PEP12 |
YOR036W |
Target membrane receptor (t-SNARE) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
ELO2 |
YCR034W |
Fatty acid elongase, involved in sphingolipid biosynthesis |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SEC1 |
YDR164C |
Sm-like protein involved in docking and fusion of exocytic vesicles |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
SEC1 |
YDR164C |
Sm-like protein involved in docking and fusion of exocytic vesicles |
genetic |
1 |
1 |
1 |
Dosage Rescue |
SRO7 |
YPR032W |
Effector of Rab GTPase Sec4p |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
SYN8 |
YAL014C |
Endosomal SNARE related to mammalian syntaxin 8 |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
VPS54 |
YDR027C |
Component of the GARP (Golgi-associated retrograde protein) complex |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
TLG1 |
YDR468C |
Essential t-SNARE that mediates fusion of vesicles with the late Golgi |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
TLG1 |
YDR468C |
Essential t-SNARE that mediates fusion of vesicles with the late Golgi |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SRO9 |
YCL037C |
Cytoplasmic RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
SSA1 |
YAL005C |
ATPase involved in protein folding and NLS-directed nuclear transport |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SNC2 |
YOR327C |
Vesicle membrane receptor protein (v-SNARE) |
physical |
1 |
1 |
1 |
Co-fractionation |
SSB2 |
YNL209W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
1 |
1 |
1 |
Co-purification |
SYP1 |
YCR030C |
Negative regulator of WASP-Arp23 complex |
physical |
1 |
1 |
1 |
Reconstituted Complex |
SWH1 |
YAR042W |
Protein similar to mammalian oxysterol-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
TLG2 |
YOL018C |
Syntaxin-like t-SNARE |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VAM3 |
YOR106W |
Syntaxin-like vacuolar t-SNARE |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
VPS1 |
YKR001C |
Dynamin-like GTPase required for vacuolar sorting |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
VPS34 |
YLR240W |
Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
YPP1 |
YGR198W |
Cargo-transport protein involved in endocytosis |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
YNG2 |
YHR090C |
Subunit of NuA4, an essential histone acetyltransferase complex |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
TRS85 |
YDR108W |
Component of transport protein particle (TRAPP) complex III |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
YOR1 |
YGR281W |
Plasma membrane ATP-binding cassette (ABC) transporter |
genetic |
1 |
1 |
1 |
Positive Genetic |
UME6 |
YDR207C |
Rpd3L histone deacetylase complex subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
YIL055C |
YIL055C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YLL053C |
YLL053C |
Putative protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
SLA2 |
YNL243W |
Adaptor protein that links actin to clathrin and endocytosis |
genetic |
1 |
1 |
1 |
Negative Genetic |
EAF7 |
YNL136W |
Subunit of the NuA4 histone acetyltransferase complex |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
DPM1 |
YPR183W |
Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane |
genetic |
1 |
1 |
1 |
Negative Genetic |
ERG2 |
YMR202W |
C-8 sterol isomerase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SLF1 |
YDR515W |
RNA binding protein that associates with polysomes |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
SEC14 |
YMR079W |
Phosphatidylinositol/phosphatidylcholine transfer protein |
genetic |
1 |
1 |
1 |
Dosage Rescue |
GCS1 |
YDL226C |
ADP-ribosylation factor GTPase activating protein (ARF GAP) |
physical |
1 |
1 |
1 |
Reconstituted Complex |
GCS1 |
YDL226C |
ADP-ribosylation factor GTPase activating protein (ARF GAP) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
MDM32 |
YOR147W |
Mitochondrial inner membrane protein with similarity to Mdm31p |
genetic |
1 |
1 |
1 |
Negative Genetic |
RRP17 |
YDR412W |
5' exoribonuclease required for 5' end processing of pre-60S rRNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
DPL1 |
YDR294C |
Dihydrosphingosine phosphate lyase |
genetic |
1 |
1 |
1 |
Dosage Rescue |
MDL2 |
YPL270W |
Mitochondrial inner membrane half-type ABC transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
IZH2 |
YOL002C |
Plasma membrane receptor for plant antifungal osmotin |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PLB2 |
YMR006C |
Phospholipase B (lysophospholipase) involved in lipid metabolism |
genetic |
1 |
1 |
1 |
Negative Genetic |