CUR1 |
YPR158W |
Sorting factor, central regulator of spatial protein quality control |
genetic |
4 |
2 |
4 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement |
TDA3 |
YHR009C |
Putative oxidoreductase involved in late endosome to Golgi transport |
physical |
4 |
3 |
2 |
Two-hybrid, Affinity Capture-Western, Co-localization, Affinity Capture-Western |
HSP42 |
YDR171W |
Small heat shock protein (sHSP) with chaperone activity |
genetic |
3 |
2 |
3 |
Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement |
SNC1 |
YAL030W |
Vesicle membrane receptor protein (v-SNARE) |
physical |
3 |
2 |
2 |
Affinity Capture-Western, Two-hybrid, Affinity Capture-Western |
SIS1 |
YNL007C |
Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p |
physical |
3 |
2 |
1 |
Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex |
HSF1 |
YGL073W |
Trimeric heat shock transcription factor |
regulation |
2 |
2 |
2 |
chromatin immunoprecipitation-chip evidence, DNA to cDNA expression microarray evidence |
YIF1 |
YNL263C |
Integral membrane protein |
physical |
2 |
2 |
2 |
Two-hybrid, Affinity Capture-Western |
IST2 |
YBR086C |
Cortical ER protein involved in ER-plasma membrane (PM) tethering |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Rescue |
YHC3 |
YJL059W |
Protein required for the ATP-dependent transport of arginine |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Synthetic Lethality |
SEC11 |
YIR022W |
18kDa catalytic subunit of the Signal Peptidase Complex (SPC) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MGM1 |
YOR211C |
Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
ERR1 |
YOR393W |
Putative phosphopyruvate hydratase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
IST2 |
YBR086C |
Cortical ER protein involved in ER-plasma membrane (PM) tethering |
physical |
2 |
2 |
1 |
Affinity Capture-Western, Co-localization |
TDA3 |
YHR009C |
Putative oxidoreductase involved in late endosome to Golgi transport |
genetic |
2 |
1 |
1 |
Phenotypic Suppression, Phenotypic Suppression |
DPB3 |
YBR278W |
Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
UBP1 |
YDL122W |
Ubiquitin-specific protease |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
RPD3 |
YNL330C |
Histone deacetylase, component of both the Rpd3S and Rpd3L complexes |
genetic |
2 |
1 |
1 |
Dosage Lethality, Dosage Lethality |
FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
GCN5 |
YGR252W |
Catalytic subunit of ADA and SAGA histone acetyltransferase complexes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
AFT2 |
YPL202C |
Iron-regulated transcriptional activator |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
FKH2 |
YNL068C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
MED2 |
YDL005C |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
RGR1 |
YLR071C |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
RPN4 |
YDL020C |
Transcription factor that stimulates expression of proteasome genes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
XBP1 |
YIL101C |
Transcriptional repressor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
YAP1 |
YML007W |
Basic leucine zipper (bZIP) transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
REB1 |
YBR049C |
RNA polymerase I enhancer binding protein |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
MIG1 |
YGL035C |
Transcription factor involved in glucose repression |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
SUA7 |
YPR086W |
Transcription factor TFIIB |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
SPT3 |
YDR392W |
Subunit of the SAGA and SAGA-like transcriptional regulatory complexes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
SPT7 |
YBR081C |
Subunit of the SAGA transcriptional regulatory complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
SPT6 |
YGR116W |
Nucleosome remodeling protein |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
UME6 |
YDR207C |
Rpd3L histone deacetylase complex subunit |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
ADA2 |
YDR448W |
Transcription coactivator |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
NCB2 |
YDR397C |
Subunit of a heterodimeric NC2 transcription regulator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
SRB5 |
YGR104C |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
UGA3 |
YDL170W |
Transcriptional activator for GABA-dependent induction of GABA genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
RTG3 |
YBL103C |
bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
CRZ1 |
YNL027W |
Transcription factor, activates transcription of stress response genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
MOT3 |
YMR070W |
Transcriptional repressor, activator |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
MSS11 |
YMR164C |
Transcription factor |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
RPH1 |
YER169W |
JmjC domain-containing histone demethylase |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
NHP6A |
YPR052C |
High-mobility group (HMG) protein |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
UME1 |
YPL139C |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
ADA2 |
YDR448W |
Transcription coactivator |
physical |
1 |
1 |
1 |
Two-hybrid |
SEC27 |
YGL137W |
Essential beta'-coat protein of the COPI coatomer |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
FDO1 |
YMR144W |
Protein involved in directionality of mating type switching |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TLG2 |
YOL018C |
Syntaxin-like t-SNARE |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
TLG1 |
YDR468C |
Essential t-SNARE that mediates fusion of vesicles with the late Golgi |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
VTI1 |
YMR197C |
Protein involved in cis-Golgi membrane traffic |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
SNC1 |
YAL030W |
Vesicle membrane receptor protein (v-SNARE) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SNC2 |
YOR327C |
Vesicle membrane receptor protein (v-SNARE) |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
VPS35 |
YJL154C |
Endosomal subunit of membrane-associated retromer complex |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
PEP8 |
YJL053W |
Vacuolar protein component of the retromer |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
SNX4 |
YJL036W |
Sorting nexin |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
RNQ1 |
YCL028W |
[PIN(+)] prion |
physical |
1 |
1 |
1 |
Two-hybrid |
SPP382 |
YLR424W |
Essential protein that forms a dimer with Ntr2p |
physical |
1 |
1 |
1 |
Two-hybrid |
MAC1 |
YMR021C |
Copper-sensing transcription factor |
physical |
1 |
1 |
1 |
Two-hybrid |
SSK22 |
YCR073C |
MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway |
physical |
1 |
1 |
1 |
Two-hybrid |
RSF2 |
YJR127C |
Zinc-finger protein |
physical |
1 |
1 |
1 |
Two-hybrid |
MAP2 |
YBL091C |
Methionine aminopeptidase |
physical |
1 |
1 |
1 |
Two-hybrid |
NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
PPH21 |
YDL134C |
Catalytic subunit of protein phosphatase 2A, PP2A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CSE4 |
YKL049C |
Centromeric histone H3-like protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
GIS2 |
YNL255C |
Translational activator for mRNAs with internal ribosome entry sites |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
HSP104 |
YLL026W |
Disaggregase |
physical |
1 |
1 |
1 |
Co-localization |
SIS1 |
YNL007C |
Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
HSP42 |
YDR171W |
Small heat shock protein (sHSP) with chaperone activity |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
MGE1 |
YOR232W |
Mitochondrial matrix cochaperone |
physical |
1 |
1 |
1 |
Two-hybrid |
PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
CAF20 |
YOR276W |
Phosphoprotein of the mRNA cap-binding complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
PUB1 |
YNL016W |
Poly (A)+ RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RSC2 |
YLR357W |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
YML108W |
YML108W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YHR020W |
YHR020W |
Prolyl-tRNA synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
YDJ1 |
YNL064C |
Type I HSP40 co-chaperone |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
PRE1 |
YER012W |
Beta 4 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
DIA2 |
YOR080W |
Origin-binding F-box protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
PPH3 |
YDR075W |
Catalytic subunit of protein phosphatase PP4 complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
POL2 |
YNL262W |
Catalytic subunit of DNA polymerase (II) epsilon |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
CMD1 |
YBR109C |
Calmodulin |
genetic |
1 |
1 |
1 |
Positive Genetic |
MIC12 |
YBR262C |
Component of the MICOS complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
RFT1 |
YBL020W |
Membrane protein required for translocation of Man5GlcNac2-PP-Dol |
genetic |
1 |
1 |
1 |
Negative Genetic |
SEC5 |
YDR166C |
Essential 107kDa subunit of the exocyst complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
CCT8 |
YJL008C |
Subunit of the cytosolic chaperonin Cct ring complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SSC1 |
YJR045C |
Hsp70 family ATPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
HSP10 |
YOR020C |
Mitochondrial matrix co-chaperonin |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPT4 |
YOR259C |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
ISC10 |
YER180C |
Meiosis-specific MAPK inhibitor |
genetic |
1 |
1 |
1 |
Negative Genetic |
MPC1 |
YGL080W |
Highly conserved subunit of mitochondrial pyruvate carrier (MPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPS8A |
YBL072C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
MAF1 |
YDR005C |
Highly conserved negative regulator of RNA polymerase III |
genetic |
1 |
1 |
1 |
Negative Genetic |
LEA1 |
YPL213W |
Component of U2 snRNP complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
YHR050W-A |
YHR050W-A |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
FLO10 |
YKR102W |
Member of the FLO family of cell wall flocculation proteins |
genetic |
1 |
1 |
1 |
Negative Genetic |
ECM5 |
YMR176W |
Subunit of the Snt2C complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
YOR034C-A |
YOR034C-A |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
CSR2 |
YPR030W |
Nuclear ubiquitin protein ligase binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
SIP5 |
YMR140W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
RPL21B |
YPL079W |
Ribosomal 60S subunit protein L21B |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
RPL4A |
YBR031W |
Ribosomal 60S subunit protein L4A |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
UBR2 |
YLR024C |
Cytoplasmic ubiquitin-protein ligase (E3) |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
RPL21A |
YBR191W |
Ribosomal 60S subunit protein L21A |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
RPL11B |
YGR085C |
Ribosomal 60S subunit protein L11B |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
RPL16B |
YNL069C |
Ribosomal 60S subunit protein L16B |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
APJ1 |
YNL077W |
Hsp40 chaperone with a role in SUMO-mediated protein degradation |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
APJ1 |
YNL077W |
Hsp40 chaperone with a role in SUMO-mediated protein degradation |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
APQ12 |
YIL040W |
Nuclear envelope/ER integral membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |