| PRP43 |
YGL120C |
RNA helicase in the DEAH-box family |
physical |
20 |
6 |
12 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-fractionation, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-MS, Co-fractionation, Biochemical Activity, Reconstituted Complex, Reconstituted Complex, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Two-hybrid |
| CWC23 |
YGL128C |
Component of a complex containing Cef1p |
physical |
13 |
4 |
8 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Two-hybrid |
| NTR2 |
YKR022C |
Essential protein that forms a dimer with Ntr1p |
physical |
12 |
3 |
8 |
Affinity Capture-MS, Two-hybrid, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-Western, Two-hybrid, Two-hybrid |
| PRP8 |
YHR165C |
Component of U4/U6-U5 snRNP complex |
physical |
5 |
1 |
4 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
| CLF1 |
YLR117C |
Member of the NineTeen Complex (NTC) |
physical |
4 |
2 |
4 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western |
| PRP43 |
YGL120C |
RNA helicase in the DEAH-box family |
genetic |
4 |
4 |
3 |
Synthetic Lethality, Synthetic Growth Defect, Dosage Lethality, Negative Genetic |
| SMB1 |
YER029C |
Core Sm protein Sm B |
physical |
4 |
1 |
3 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
| PRP38 |
YGR075C |
Unique component of the U4/U6.U5 tri-snRNP particle |
genetic |
4 |
3 |
2 |
Synthetic Rescue, Synthetic Rescue, Dosage Lethality, Synthetic Lethality |
| LIF1 |
YGL090W |
Component of the DNA ligase IV complex |
physical |
3 |
2 |
2 |
Two-hybrid, Affinity Capture-Western, Two-hybrid |
| CWC2 |
YDL209C |
Member of the NineTeen Complex (NTC) |
physical |
3 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
| BRR2 |
YER172C |
RNA-dependent ATPase RNA helicase (DEIH box) |
physical |
3 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
| CEF1 |
YMR213W |
Essential splicing factor |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Affinity Capture-Western |
| CWC23 |
YGL128C |
Component of a complex containing Cef1p |
genetic |
2 |
2 |
2 |
Dosage Lethality, Synthetic Lethality |
| PRP45 |
YAL032C |
Protein required for pre-mRNA splicing |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Two-hybrid |
| PRP8 |
YHR165C |
Component of U4/U6-U5 snRNP complex |
genetic |
2 |
2 |
2 |
Dosage Rescue, Dosage Lethality |
| SNT309 |
YPR101W |
Member of the NineTeen Complex (NTC) |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Affinity Capture-Western |
| SYF1 |
YDR416W |
Member of the NineTeen Complex (NTC) |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Affinity Capture-Western |
| YJU2 |
YKL095W |
Essential protein required for pre-mRNA splicing |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Reconstituted Complex |
| NTR2 |
YKR022C |
Essential protein that forms a dimer with Ntr1p |
genetic |
2 |
2 |
2 |
Dosage Rescue, Negative Genetic |
| PRP46 |
YPL151C |
Member of the NineTeen Complex (NTC) |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| SMX3 |
YPR182W |
Core Sm protein Sm F |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| SNU114 |
YKL173W |
GTPase component of U5 snRNP involved in mRNA splicing via spliceosome |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| PMS1 |
YNL082W |
ATP-binding protein required for mismatch repair |
genetic |
2 |
2 |
1 |
Positive Genetic, Negative Genetic |
| SSA1 |
YAL005C |
ATPase involved in protein folding and NLS-directed nuclear transport |
physical |
2 |
1 |
1 |
Affinity Capture-MS, Affinity Capture-MS |
| SSB1 |
YDL229W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
2 |
1 |
1 |
Affinity Capture-MS, Affinity Capture-MS |
| PFD1 |
YJL179W |
Subunit of heterohexameric prefoldin |
physical |
2 |
1 |
1 |
Affinity Capture-MS, Affinity Capture-MS |
| SFP1 |
YLR403W |
Regulates transcription of ribosomal protein and biogenesis genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| SPT10 |
YJL127C |
Histone H3 acetylase with a role in transcriptional regulation |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| UGA3 |
YDL170W |
Transcriptional activator for GABA-dependent induction of GABA genes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| CDC73 |
YLR418C |
Component of the Paf1p complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CDC40 |
YDR364C |
Pre-mRNA splicing factor |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| CTF19 |
YPL018W |
Outer kinetochore protein, needed for accurate chromosome segregation |
physical |
1 |
1 |
1 |
Two-hybrid |
| PRP19 |
YLL036C |
Splicing factor associated with the spliceosome |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| ECM2 |
YBR065C |
Pre-mRNA splicing factor |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SMD3 |
YLR147C |
Core Sm protein Sm D3 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SYF2 |
YGR129W |
Member of the NineTeen Complex (NTC) |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| SPP382 |
YLR424W |
Essential protein that forms a dimer with Ntr2p |
physical |
1 |
1 |
1 |
Two-hybrid |
| SWC7 |
YLR385C |
Protein of unknown function |
physical |
1 |
1 |
1 |
Two-hybrid |
| SQS1 |
YNL224C |
Protein that stimulates the ATPase and helicase activities of Prp43p |
physical |
1 |
1 |
1 |
Two-hybrid |
| SQS1 |
YNL224C |
Protein that stimulates the ATPase and helicase activities of Prp43p |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| YHC1 |
YLR298C |
Component of the U1 snRNP complex required for pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| YML6 |
YML025C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| UFD2 |
YDL190C |
Ubiquitin (Ub) chain assembly factor (E4) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UBP2 |
YOR124C |
Ubiquitin-specific protease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YCR102C |
YCR102C |
Putative quinone oxidoreductase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| VAM7 |
YGL212W |
Vacuolar SNARE protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| STU1 |
YBL034C |
Microtubule plus-end-tracking non-motor protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UTP13 |
YLR222C |
Nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YAR029W |
YAR029W |
Member of DUP240 gene family but contains no transmembrane domains |
genetic |
1 |
1 |
1 |
Negative Genetic |
| XRN1 |
YGL173C |
Evolutionarily-conserved 5'-3' exonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YGR050C |
YGR050C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS53 |
YJL029C |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UBI4 |
YLL039C |
Ubiquitin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| STB4 |
YMR019W |
Putative transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YDJ1 |
YNL064C |
Type I HSP40 co-chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS27 |
YNR006W |
Endosomal protein that forms a complex with Hse1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| WHI5 |
YOR083W |
Repressor of G1 transcription |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS4 |
YPR173C |
AAA-ATPase involved in multivesicular body (MVB) protein sorting |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YGR237C |
YGR237C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TNA1 |
YGR260W |
High affinity nicotinic acid plasma membrane permease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YLL032C |
YLL032C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TRI1 |
YMR233W |
Non-essential sumoylated protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YPR089W |
YPR089W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BRE1 |
YDL074C |
E3 ubiquitin ligase |
physical |
1 |
1 |
1 |
PCA |
| HAP5 |
YOR358W |
Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RRP5 |
YMR229C |
RNA binding protein involved in synthesis of 18S and 5.8S rRNAs |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| CBC2 |
YPL178W |
Small subunit of the heterodimeric cap binding complex with Sto1p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| CBC2 |
YPL178W |
Small subunit of the heterodimeric cap binding complex with Sto1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRP39 |
YML046W |
U1 snRNP protein involved in splicing |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| NOP12 |
YOL041C |
Nucleolar protein involved in pre-25S rRNA processing |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| CTK1 |
YKL139W |
Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) |
physical |
1 |
1 |
1 |
PCA |
| EAF3 |
YPR023C |
Component of the Rpd3S histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HAT1 |
YPL001W |
Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| KGD2 |
YDR148C |
Dihydrolipoyl transsuccinylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ADA2 |
YDR448W |
Transcription coactivator |
physical |
1 |
1 |
1 |
Two-hybrid |
| MRP13 |
YGR084C |
Mitochondrial ribosomal protein of the small subunit |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| HMO1 |
YDR174W |
Chromatin associated high mobility group (HMG) family member |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PCF11 |
YDR228C |
mRNA 3' end processing factor |
physical |
1 |
1 |
1 |
Two-hybrid |
| BLM10 |
YFL007W |
Proteasome activator |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LEA1 |
YPL213W |
Component of U2 snRNP complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| DAM1 |
YGR113W |
Essential subunit of the Dam1 complex (aka DASH complex) |
physical |
1 |
1 |
1 |
Two-hybrid |
| INO4 |
YOL108C |
Transcription factor involved in phospholipid synthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PTC4 |
YBR125C |
Cytoplasmic type 2C protein phosphatase (PP2C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RKM1 |
YPL208W |
SET-domain lysine-N-methyltransferase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SMC1 |
YFL008W |
Subunit of the multiprotein cohesin complex |
physical |
1 |
1 |
1 |
Two-hybrid |
| SMX2 |
YFL017W-A |
Core Sm protein Sm G |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SGV1 |
YPR161C |
Cyclin (Bur2p)-dependent protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CAM1 |
YPL048W |
One of two isoforms of the gamma subunit of eEF1B |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| ATG17 |
YLR423C |
Scaffold protein responsible for phagophore assembly site organization |
physical |
1 |
1 |
1 |
Two-hybrid |
| ERG27 |
YLR100W |
3-keto sterol reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| INM1 |
YHR046C |
Inositol monophosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC37 |
YDR168W |
Essential Hsp90p co-chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CAC2 |
YML102W |
Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| NTG1 |
YAL015C |
DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD14 |
YMR201C |
Subunit of Nucleotide Excision Repair Factor 1 (NEF1) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BTN2 |
YGR142W |
v-SNARE binding protein |
physical |
1 |
1 |
1 |
Two-hybrid |
| GNA1 |
YFL017C |
Glucosamine-6-phosphate acetyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GZF3 |
YJL110C |
GATA zinc finger protein |
physical |
1 |
1 |
1 |
Two-hybrid |
| NUP57 |
YGR119C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ISY1 |
YJR050W |
Member of the NineTeen Complex (NTC) |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| NTC20 |
YBR188C |
Member of the NineTeen Complex (NTC) |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| ASK10 |
YGR097W |
Regulator of the Fps1p glycerol channel |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC27 |
YBL084C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
physical |
1 |
1 |
1 |
Two-hybrid |
| RPL4A |
YBR031W |
Ribosomal 60S subunit protein L4A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| CHL1 |
YPL008W |
Probable DNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CST6 |
YIL036W |
Basic leucine zipper (bZIP) transcription factor from ATF/CREB family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AMD1 |
YML035C |
AMP deaminase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SKO1 |
YNL167C |
Basic leucine zipper transcription factor of the ATF/CREB family |
physical |
1 |
1 |
1 |
PCA |
| CCZ1 |
YBR131W |
Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SNX4 |
YJL036W |
Sorting nexin |
physical |
1 |
1 |
1 |
Two-hybrid |
| PET123 |
YOR158W |
Mitochondrial ribosomal protein of the small subunit |
physical |
1 |
1 |
1 |
Two-hybrid |
| DAL80 |
YKR034W |
Negative regulator of genes in multiple nitrogen degradation pathways |
physical |
1 |
1 |
1 |
Two-hybrid |
| SHE9 |
YDR393W |
Protein required for normal mitochondrial morphology |
genetic |
1 |
1 |
1 |
Negative Genetic |
| JHD2 |
YJR119C |
JmjC domain family histone demethylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BAP3 |
YDR046C |
Amino acid permease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GPI2 |
YPL076W |
Protein involved in the synthesis of GlcNAc-PI |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HSK3 |
YKL138C-A |
Essential subunit of the Dam1 complex (aka DASH complex) |
physical |
1 |
1 |
1 |
Two-hybrid |
| GID11 |
YLR149C |
Substrate receptor of the glucose-induced degradation-deficient (GID) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HTD2 |
YHR067W |
Mitochondrial 3-hydroxyacyl-thioester dehydratase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CUL3 |
YGR003W |
Ubiquitin-protein ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ETR1 |
YBR026C |
2-enoyl thioester reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ELF1 |
YKL160W |
Transcription elongation factor with a conserved zinc finger domain |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FMP46 |
YKR049C |
Putative redox protein containing a thioredoxin fold |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SDO1 |
YLR022C |
Guanine nucleotide exchange factor (GEF) for Ria1p |
physical |
1 |
1 |
1 |
Two-hybrid |
| LIP5 |
YOR196C |
Protein involved in biosynthesis of the coenzyme lipoic acid |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POM33 |
YLL023C |
Transmembrane nucleoporin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL8A |
YHL033C |
Ribosomal 60S subunit protein L8A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NEJ1 |
YLR265C |
DNA end-binding protein required for nonhomologous end joining (NHEJ) |
physical |
1 |
1 |
1 |
Two-hybrid |
| COX10 |
YPL172C |
Heme A:farnesyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL14A |
YKL006W |
Ribosomal 60S subunit protein L14A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SNX3 |
YOR357C |
Sorting nexin for late-Golgi enzymes |
physical |
1 |
1 |
1 |
Two-hybrid |
| ERV1 |
YGR029W |
Flavin-linked sulfhydryl oxidase of the mitochondrial IMS |
physical |
1 |
1 |
1 |
Two-hybrid |
| AIM34 |
YMR003W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| COT1 |
YOR316C |
Vacuolar transporter that mediates zinc transport into the vacuole |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CHO2 |
YGR157W |
Phosphatidylethanolamine methyltransferase (PEMT) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ATG15 |
YCR068W |
Phospholipase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| FAD1 |
YDL045C |
Flavin adenine dinucleotide (FAD) synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MDM35 |
YKL053C-A |
Mitochondrial intermembrane space protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FMC1 |
YIL098C |
Mitochondrial matrix protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GPI10 |
YGL142C |
Integral membrane protein involved in GPI anchor synthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CRD1 |
YDL142C |
Cardiolipin synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MCT1 |
YOR221C |
Predicted malonyl-CoA:ACP transferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OAR1 |
YKL055C |
Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NCA3 |
YJL116C |
Protein involved in mitochondrion organization |
genetic |
1 |
1 |
1 |
Negative Genetic |
