Standard name Systematic name Name description Description
CDC73 YLR418C Component of the Paf1p complex Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress; human homolog, parafibromin, is a tumour suppressor linked to breast, renal and gastric cancers
Visualize the interactome of CDC73
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.066 NaN NaN
Nucleolus 0.540 0.603 0.504
Nucleus 0.730 0.759 0.782

GFP localization & abundance

GFP localization GFP abundance
nucleus 538

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
CDC73 13 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
CTR9 YOL145C Component of the Paf1p complex involved in transcription elongation physical 20 3 14 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western
PAF1 YBR279W Component of the Paf1p complex involved in transcription elongation physical 18 2 14 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex physical 17 3 13 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Co-purification, Affinity Capture-MS, Affinity Capture-Western
LEO1 YOR123C Component of the Paf1 complex physical 15 3 11 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 11 3 7 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 11 3 7 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 11 4 6 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Rescue, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
HTZ1 YOL012C Histone variant H2AZ genetic 10 3 8 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 10 1 8 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 10 3 7 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 10 3 7 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
SWC3 YAL011W Protein of unknown function genetic 9 3 6 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
VPS72 YDR485C Htz1p-binding component of the SWR1 complex genetic 9 3 6 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 8 3 7 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
RTT109 YLL002W Histone acetyltransferase genetic 8 3 7 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
THP2 YHR167W Subunit of the THO and TREX complexes genetic 8 3 6 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 8 3 6 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
CTI6 YPL181W Component of the Rpd3L histone deacetylase complex genetic 8 3 5 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
LEO1 YOR123C Component of the Paf1 complex genetic 7 3 6 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 7 3 6 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
HIR3 YJR140C Subunit of the HIR complex genetic 7 3 6 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 7 3 6 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 7 3 6 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 7 2 6 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 7 3 5 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 7 3 5 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
GET1 YGL020C Subunit of the GET complex genetic 7 2 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 7 2 5 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation genetic 7 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CIN8 YEL061C Bipolar kinesin motor protein genetic 6 3 6 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
ELF1 YKL160W Transcription elongation factor with a conserved zinc finger domain genetic 6 3 6 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 6 3 6 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Positive Genetic
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 6 2 6 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex genetic 6 2 6 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect
RPO21 YDL140C RNA polymerase II largest subunit B220 physical 6 4 5 Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, PCA, Affinity Capture-MS, Affinity Capture-Western
SPT2 YER161C Protein involved in negative regulation of transcription genetic 6 3 5 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect
UBP6 YFR010W Ubiquitin-specific protease genetic 6 3 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 6 3 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
IST3 YIR005W Component of the U2 snRNP genetic 6 3 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
RUD3 YOR216C Golgi matrix protein genetic 6 3 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
HIR1 YBL008W Subunit of the HIR complex genetic 6 2 5 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
THP1 YOL072W Nuclear pore-associated protein genetic 5 4 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement
DST1 YGL043W General transcription elongation factor TFIIS genetic 5 3 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 5 3 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 5 3 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
HIR2 YOR038C Subunit of HIR nucleosome assembly complex genetic 5 3 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 5 3 5 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic, Positive Genetic
RAD52 YML032C Protein involved in homologous recombination genetic 5 3 5 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Phenotypic Suppression
VPS21 YOR089C Endosomal Rab family GTPase genetic 5 2 5 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
GET2 YER083C Subunit of the GET complex genetic 5 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
LEA1 YPL213W Component of U2 snRNP complex genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BUD27 YFL023W Unconventional prefoldin protein involved in translation initiation genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex genetic 4 4 4 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement
RPB2 YOR151C RNA polymerase II second largest subunit B150 physical 4 3 4 Co-purification, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex
SIF2 YBR103W WD40 repeat-containing subunit of Set3C histone deacetylase complex genetic 4 3 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect
HPC2 YBR215W Subunit of the HIR complex genetic 4 3 4 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic
SLM3 YDL033C tRNA-specific 2-thiouridylase genetic 4 3 4 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic
YPT6 YLR262C Rab family GTPase genetic 4 3 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect
IKI3 YLR384C Subunit of Elongator complex genetic 4 3 4 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 4 3 4 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic
TIM18 YOR297C Component of the mitochondrial TIM22 complex genetic 4 3 4 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic
SNU66 YOR308C Component of the U4/U6.U5 snRNP complex genetic 4 3 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect
BUD13 YGL174W Subunit of the RES complex genetic 4 3 4 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 4 3 4 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic
APQ12 YIL040W Nuclear envelope/ER integral membrane protein genetic 4 3 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect
RTR1 YER139C Dual specificity protein phosphatase genetic 4 2 4 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 4 2 4 Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 4 2 4 Synthetic Growth Defect, Positive Genetic, Positive Genetic, Positive Genetic
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 4 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
RTT103 YDR289C Protein involved in transcription termination by RNA polymerase II genetic 4 2 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
SPC24 YMR117C Component of the kinetochore-associated Ndc80 complex genetic 4 2 4 Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription genetic 4 1 4 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
UME1 YPL139C Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 4 3 3 Negative Genetic, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect
RPB3 YIL021W RNA polymerase II third largest subunit B44 physical 4 2 3 Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex
URM1 YIL008W Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs genetic 4 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
CEM1 YER061C Mitochondrial beta-keto-acyl synthase genetic 4 2 3 Negative Genetic, Negative Genetic, Negative Genetic, Positive Genetic
BUL1 YMR275C Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex genetic 4 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
TIM13 YGR181W Mitochondrial intermembrane space protein genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
MMS4 YBR098W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
HCM1 YCR065W Forkhead transcription factor genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 4 1 3 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 4 1 2 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
VPS9 YML097C Guanine nucleotide exchange factor (GEF) and ubiquitin receptor genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SGF11 YPL047W Integral subunit of SAGA histone acetyltransferase complex genetic 4 1 2 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
HDA3 YPR179C Subunit of HDA1 histone deacetylase complex genetic 4 1 2 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
VAC8 YEL013W Vacuole-specific Myo2p receptor genetic 3 3 3 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
SPF1 YEL031W P-type ATPase, ion transporter of the ER membrane genetic 3 3 3 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect
GLO3 YER122C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 3 3 3 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
MET18 YIL128W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 3 3 3 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect
UPS2 YLR168C Mitochondrial intermembrane space protein genetic 3 3 3 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 3 3 3 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 3 3 3 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect
MDM38 YOL027C Membrane-associated mitochondrial ribosome receptor genetic 3 3 3 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect
YPR084W YPR084W Putative protein of unknown function genetic 3 3 3 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect
MED8 YBR193C Subunit of the RNA polymerase II mediator complex genetic 3 3 3 Synthetic Growth Defect, Synthetic Lethality, Positive Genetic
TUB4 YLR212C Gamma-tubulin genetic 3 3 3 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect
GAL11 YOL051W Subunit of the RNA polymerase II mediator complex physical 3 2 3 Affinity Capture-Western, Affinity Capture-Western, PCA
RPB11 YOL005C RNA polymerase II subunit B12.5 physical 3 2 3 Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 3 2 3 Synthetic Growth Defect, Positive Genetic, Positive Genetic
UBP2 YOR124C Ubiquitin-specific protease genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 3 2 3 Negative Genetic, Negative Genetic, Phenotypic Enhancement
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
PET309 YLR067C Specific translational activator for the COX1 mRNA genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
PCF11 YDR228C mRNA 3' end processing factor genetic 3 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 3 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 3 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic
PRP4 YPR178W Splicing factor genetic 3 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic
GOS1 YHL031C v-SNARE protein involved in Golgi transport genetic 3 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
SMC1 YFL008W Subunit of the multiprotein cohesin complex genetic 3 2 3 Synthetic Lethality, Positive Genetic, Positive Genetic
SCH9 YHR205W AGC family protein kinase genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 3 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic
ASF1 YJL115W Nucleosome assembly factor genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
CCS1 YMR038C Copper chaperone for superoxide dismutase Sod1p genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 3 1 3 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
SET3 YKR029C Defining member of the SET3 histone deacetylase complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SAC3 YDR159W mRNA export factor genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 3 1 3 Positive Genetic, Positive Genetic, Positive Genetic
SKY1 YMR216C SR protein kinase (SRPK) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
BRE1 YDL074C E3 ubiquitin ligase genetic 3 1 3 Positive Genetic, Positive Genetic, Positive Genetic
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 3 3 2 Synthetic Lethality, Positive Genetic, Negative Genetic
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 3 2 2 Negative Genetic, Negative Genetic, Synthetic Growth Defect
CDC45 YLR103C DNA replication initiation factor genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Negative Genetic
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 3 1 2 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MDM10 YAL010C Subunit of both the ERMES and the SAM complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
THR4 YCR053W Threonine synthase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SSD1 YDR293C Translational repressor genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
OMS1 YDR316W Protein integral to the mitochondrial membrane genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HOM3 YER052C Aspartate kinase (L-aspartate 4-P-transferase) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MGR3 YMR115W Subunit of the mitochondrial (mt) i-AAA protease supercomplex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CIK1 YMR198W Kinesin-associated protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ODC1 YPL134C Mitochondrial inner membrane transporter genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SKI3 YPR189W Ski complex component and TPR protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ARV1 YLR242C Cortical ER protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 2 2 2 Synthetic Lethality, Negative Genetic
CDC73 YLR418C Component of the Paf1p complex physical 2 2 2 Affinity Capture-MS, PCA
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
TFG2 YGR005C TFIIF (Transcription Factor II) middle subunit physical 2 2 2 Affinity Capture-Western, Co-purification
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
SUA7 YPR086W Transcription factor TFIIB physical 2 2 2 Co-purification, PCA
SPT15 YER148W TATA-binding protein (TBP) physical 2 2 2 Co-fractionation, PCA
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
SRO9 YCL037C Cytoplasmic RNA-binding protein genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
RPB11 YOL005C RNA polymerase II subunit B12.5 genetic 2 2 2 Synthetic Lethality, Negative Genetic
RPB3 YIL021W RNA polymerase II third largest subunit B44 genetic 2 2 2 Synthetic Lethality, Negative Genetic
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
LSM6 YDR378C Lsm (Like Sm) protein genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
VID30 YGL227W Central component of GID Complex, involved in FBPase degradation genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
MDM35 YKL053C-A Mitochondrial intermembrane space protein genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
LST4 YKL176C Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
MMR1 YLR190W Phosphorylated protein of the mitochondrial outer membrane genetic 2 2 2 Synthetic Lethality, Negative Genetic
QRI5 YLR204W Mitochondrial inner membrane protein genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
MRPS8 YMR158W Mitochondrial ribosomal protein of the small subunit genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
RCE1 YMR274C Type II CAAX prenyl protease genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
DIA2 YOR080W Origin-binding F-box protein genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
PDE2 YOR360C High-affinity cyclic AMP phosphodiesterase genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
CET1 YPL228W RNA 5'-triphosphatase involved in mRNA 5' capping genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
FCP1 YMR277W Carboxy-terminal domain (CTD) phosphatase genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 2 2 2 Synthetic Lethality, Positive Genetic
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
MFT1 YML062C Subunit of the THO complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) genetic 2 2 2 Negative Genetic, Phenotypic Enhancement
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
NPL3 YDR432W RNA-binding protein genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
UBA4 YHR111W E1-like protein that activates Urm1p before urmylation genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SHR3 YDL212W Endoplasmic reticulum packaging chaperone genetic 2 2 2 Negative Genetic, Synthetic Lethality
TSC13 YDL015C Enoyl reductase genetic 2 2 2 Negative Genetic, Synthetic Lethality
RML2 YEL050C Mitochondrial ribosomal protein of the large subunit (L2) genetic 2 2 2 Negative Genetic, Phenotypic Enhancement
LSM4 YER112W Lsm (Like Sm) protein genetic 2 2 2 Negative Genetic, Synthetic Lethality
USE1 YGL098W Essential SNARE protein localized to the ER genetic 2 2 2 Negative Genetic, Synthetic Lethality
PGA3 YML125C Putative cytochrome b5 reductase, localized to the plasma membrane genetic 2 2 2 Negative Genetic, Synthetic Lethality
MGE1 YOR232W Mitochondrial matrix cochaperone genetic 2 2 2 Negative Genetic, Synthetic Lethality
YNG1 YOR064C Subunit of the NuA3 histone acetyltransferase complex genetic 2 2 2 Synthetic Rescue, Positive Genetic
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
RCO1 YMR075W Essential component of the Rpd3S histone deacetylase complex genetic 2 2 2 Synthetic Rescue, Positive Genetic
MED7 YOL135C Subunit of the RNA polymerase II mediator complex genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
SDO1 YLR022C Guanine nucleotide exchange factor (GEF) for Ria1p genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 2 2 2 Synthetic Lethality, Positive Genetic
PRP6 YBR055C Splicing factor genetic 2 2 2 Synthetic Lethality, Negative Genetic
IRA1 YBR140C GTPase-activating protein genetic 2 2 2 Synthetic Lethality, Negative Genetic
RIM2 YBR192W Mitochondrial pyrimidine nucleotide transporter genetic 2 2 2 Synthetic Lethality, Negative Genetic
RPT2 YDL007W ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 2 2 Synthetic Lethality, Negative Genetic
USO1 YDL058W Essential protein involved in vesicle-mediated ER to Golgi transport genetic 2 2 2 Synthetic Lethality, Negative Genetic
YRB1 YDR002W Ran GTPase binding protein genetic 2 2 2 Synthetic Lethality, Negative Genetic
PRP28 YDR243C Pre-mRNA splicing factor genetic 2 2 2 Synthetic Lethality, Negative Genetic
SRP101 YDR292C Signal recognition particle (SRP) receptor alpha subunit genetic 2 2 2 Synthetic Lethality, Positive Genetic
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 2 2 2 Synthetic Lethality, Negative Genetic
FCF1 YDR339C PINc domain endonuclease genetic 2 2 2 Synthetic Lethality, Positive Genetic
FRQ1 YDR373W N-myristoylated calcium-binding protein genetic 2 2 2 Synthetic Lethality, Negative Genetic
SEC20 YDR498C Membrane glycoprotein v-SNARE genetic 2 2 2 Synthetic Lethality, Negative Genetic
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
GCD11 YER025W Gamma subunit of the translation initiation factor eIF2 genetic 2 2 2 Synthetic Lethality, Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 2 2 2 Synthetic Lethality, Negative Genetic
SPB4 YFL002C Putative ATP-dependent RNA helicase genetic 2 2 2 Synthetic Lethality, Positive Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 2 2 2 Synthetic Lethality, Negative Genetic
TUB2 YFL037W Beta-tubulin genetic 2 2 2 Synthetic Lethality, Negative Genetic
PRP31 YGR091W Splicing factor genetic 2 2 2 Synthetic Lethality, Negative Genetic
NDC80 YIL144W Component of the kinetochore-associated Ndc80 complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
EXO70 YJL085W Subunit of the exocyst complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
DPB11 YJL090C DNA replication initiation protein genetic 2 2 2 Synthetic Lethality, Negative Genetic
RPF2 YKR081C Essential protein involved in rRNA maturation and ribosomal assembly genetic 2 2 2 Synthetic Lethality, Positive Genetic
SSL1 YLR005W Subunit of the core form of RNA polymerase transcription factor TFIIH genetic 2 2 2 Synthetic Lethality, Negative Genetic
TEN1 YLR010C Protein that regulates telomeric length genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
TAP42 YMR028W Essential protein involved in the TOR signaling pathway genetic 2 2 2 Synthetic Lethality, Negative Genetic
RNA14 YMR061W Component of the cleavage and polyadenylation factor I (CF I) genetic 2 2 2 Synthetic Lethality, Negative Genetic
VTI1 YMR197C Protein involved in cis-Golgi membrane traffic genetic 2 2 2 Synthetic Lethality, Negative Genetic
CUS1 YMR240C Protein required for assembly of U2 snRNP into the spliceosome genetic 2 2 2 Synthetic Lethality, Negative Genetic
CSL4 YNL232W Exosome non-catalytic core component genetic 2 2 2 Synthetic Lethality, Negative Genetic
PUP1 YOR157C Beta 2 subunit of the 20S proteasome genetic 2 2 2 Synthetic Lethality, Negative Genetic
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 2 2 2 Synthetic Lethality, Positive Genetic
GPN2 YOR262W Putative GTPase with a specific role in RNA pol II and polIII biogenes genetic 2 2 2 Synthetic Lethality, Negative Genetic
DPM1 YPR183W Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane genetic 2 2 2 Synthetic Lethality, Negative Genetic
CRC1 YOR100C Mitochondrial inner membrane carnitine transporter genetic 2 2 2 Positive Genetic, Negative Genetic
AME1 YBR211C Essential kinetochore protein associated with microtubules and SPBs genetic 2 2 2 Synthetic Lethality, Negative Genetic
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 2 2 2 Synthetic Lethality, Positive Genetic
AAR2 YBL074C Component of the U5 snRNP complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
ARD1 YHR013C Subunit of protein N-terminal acetyltransferase NatA genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p genetic 2 2 2 Negative Genetic, Positive Genetic
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 2 2 2 Synthetic Lethality, Negative Genetic
SRB5 YGR104C Subunit of the RNA polymerase II mediator complex physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PDB1 YBR221C E1 beta subunit of the pyruvate dehydrogenase (PDH) complex genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 2 1 2 Negative Genetic, Negative Genetic
CKA2 YOR061W Alpha' catalytic subunit of casein kinase 2 (CK2) physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 2 1 2 Positive Genetic, Positive Genetic
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 2 1 2 Negative Genetic, Negative Genetic
RPB4 YJL140W RNA polymerase II subunit B32 genetic 2 1 2 Positive Genetic, Positive Genetic
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase genetic 2 1 2 Negative Genetic, Negative Genetic
SNT1 YCR033W Set3C histone deacetylase scaffold genetic 2 1 2 Negative Genetic, Negative Genetic
SWI3 YJL176C Subunit of the SWI/SNF chromatin remodeling complex genetic 2 1 2 Negative Genetic, Negative Genetic
TRS85 YDR108W Component of transport protein particle (TRAPP) complex III genetic 2 1 2 Negative Genetic, Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 2 1 2 Negative Genetic, Negative Genetic
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
PSY2 YNL201C Subunit of protein phosphatase PP4 complex genetic 2 1 2 Negative Genetic, Negative Genetic
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 2 1 2 Negative Genetic, Negative Genetic
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 2 1 2 Negative Genetic, Negative Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 2 1 2 Negative Genetic, Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 2 1 2 Negative Genetic, Negative Genetic
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 2 1 2 Negative Genetic, Negative Genetic
CTF4 YPR135W Chromatin-associated protein genetic 2 1 2 Negative Genetic, Negative Genetic
SAP190 YKR028W Protein that forms a complex with the Sit4p protein phosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 2 1 2 Positive Genetic, Positive Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 2 1 2 Positive Genetic, Positive Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 2 1 2 Positive Genetic, Positive Genetic
HOS2 YGL194C Histone deacetylase and subunit of Set3 and Rpd3L complexes genetic 2 1 2 Negative Genetic, Negative Genetic
PAN3 YKL025C Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex genetic 2 1 2 Negative Genetic, Negative Genetic
FPR1 YNL135C Peptidyl-prolyl cis-trans isomerase (PPIase) genetic 2 1 2 Positive Genetic, Positive Genetic
VMA9 YCL005W-A Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex genetic 2 1 2 Positive Genetic, Positive Genetic
PRP22 YER013W DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase genetic 2 1 2 Positive Genetic, Positive Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 2 1 2 Negative Genetic, Negative Genetic
TCP1 YDR212W Alpha subunit of chaperonin-containing T-complex genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
SRM1 YGL097W Nucleotide exchange factor for Gsp1p genetic 2 1 2 Negative Genetic, Negative Genetic
DUO1 YGL061C Essential subunit of the Dam1 complex (aka DASH complex) genetic 2 1 2 Negative Genetic, Negative Genetic
GWT1 YJL091C Protein involved in the inositol acylation of GlcN-PI genetic 2 1 2 Negative Genetic, Negative Genetic
CLG1 YGL215W Cyclin-like protein that interacts with Pho85p genetic 2 1 2 Negative Genetic, Negative Genetic
DID2 YKR035W-A Class E protein of the vacuolar protein-sorting (Vps) pathway genetic 2 1 2 Negative Genetic, Negative Genetic
MSC1 YML128C Protein of unknown function genetic 2 1 2 Positive Genetic, Positive Genetic
MDM12 YOL009C Mitochondrial outer membrane protein, ERMES complex subunit genetic 2 1 2 Negative Genetic, Negative Genetic
PSD1 YNL169C Phosphatidylserine decarboxylase of the mitochondrial inner membrane genetic 2 1 2 Negative Genetic, Negative Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 2 Negative Genetic, Negative Genetic
ECM8 YBR076W Non-essential protein of unknown function genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
RGP1 YDR137W Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
MSN5 YDR335W Karyopherin genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
SWI6 YLR182W Transcription cofactor genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
LIP2 YLR239C Lipoyl ligase genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
NKP2 YLR315W Central kinetochore protein and subunit of the Ctf19 complex genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
RIM13 YMR154C Calpain-like cysteine protease genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
RRP6 YOR001W Nuclear exosome exonuclease component genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
DFG16 YOR030W Probable multiple transmembrane protein genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
KSP1 YHR082C Serine/threonine protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 2 1 2 Negative Genetic, Negative Genetic
SGT1 YOR057W Cochaperone protein genetic 2 1 2 Negative Genetic, Negative Genetic
SPN1 YPR133C Protein involved in RNA polymerase II transcription genetic 2 1 2 Negative Genetic, Negative Genetic
HAP3 YBL021C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 2 1 2 Negative Genetic, Negative Genetic
DCD1 YHR144C Deoxycytidine monophosphate (dCMP) deaminase genetic 2 1 2 Negative Genetic, Negative Genetic
NUC1 YJL208C Major mitochondrial nuclease genetic 2 1 2 Negative Genetic, Negative Genetic
MOT3 YMR070W Transcriptional repressor, activator genetic 2 1 2 Negative Genetic, Negative Genetic
SSK2 YNR031C MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway genetic 2 1 2 Negative Genetic, Negative Genetic
SER1 YOR184W 3-phosphoserine aminotransferase genetic 2 1 2 Negative Genetic, Negative Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 2 1 2 Negative Genetic, Negative Genetic
AKR1 YDR264C Palmitoyl transferase involved in protein palmitoylation genetic 2 1 2 Negative Genetic, Negative Genetic
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes genetic 2 2 1 Positive Genetic, Negative Genetic
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p genetic 2 2 1 Negative Genetic, Positive Genetic
HSP104 YLL026W Disaggregase physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
HSP78 YDR258C Oligomeric mitochondrial matrix chaperone physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
SSA2 YLL024C HSP70 family ATP-binding protein physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
HHT1 YBR010W Histone H3 genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
VID24 YBR105C GID Complex regulatory subunit genetic 2 1 1 Negative Genetic, Negative Genetic
EMI1 YDR512C Non-essential protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
FYV10 YIL097W Subunit of GID complex genetic 2 1 1 Negative Genetic, Negative Genetic
YIR016W YIR016W Putative protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
YUH1 YJR099W Ubiquitin C-terminal hydrolase genetic 2 1 1 Negative Genetic, Negative Genetic
DGK1 YOR311C Diacylglycerol kinase genetic 2 1 1 Negative Genetic, Negative Genetic
MGR2 YPL098C Subunit of the TIM23 translocase complex genetic 2 1 1 Negative Genetic, Negative Genetic
SOV1 YMR066W Mitochondrial protein of unknown function genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
MPS3 YJL019W Nuclear envelope protein genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
TIM22 YDL217C Essential core component of mitochondrial TIM22 complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BNA1 YJR025C 3-hydroxyanthranilic acid dioxygenase regulation 1 1 1 DNA to cDNA expression microarray evidence
SER3 YER081W 3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase regulation 1 1 1 DNA to cDNA expression microarray evidence
ILV5 YLR355C Acetohydroxyacid reductoisomerase and mtDNA binding protein regulation 1 1 1 DNA to cDNA expression microarray evidence
AGA2 YGL032C Adhesion subunit of a-agglutinin of a-cells regulation 1 1 1 DNA to cDNA expression microarray evidence
YGL039W YGL039W Aldehyde reductase regulation 1 1 1 DNA to cDNA expression microarray evidence
AGA1 YNR044W Anchorage subunit of a-agglutinin of a-cells regulation 1 1 1 DNA to cDNA expression microarray evidence
ARG1 YOL058W Arginosuccinate synthetase regulation 1 1 1 DNA to cDNA expression microarray evidence
ARN1 YHL040C ARN family transporter for siderophore-iron chelates regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
BAR1 YIL015W Aspartyl protease secreted to periplasmic space of mating type a cell regulation 1 1 1 DNA to cDNA expression microarray evidence
DBP2 YNL112W ATP-dependent RNA helicase of the DEAD-box protein family regulation 1 1 1 DNA to cDNA expression microarray evidence
LEU2 YCL018W Beta-isopropylmalate dehydrogenase (IMDH) regulation 1 1 1 DNA to cDNA expression microarray evidence
AGP1 YCL025C Broad-specificity, low-affinity amino acid permease regulation 1 1 1 DNA to cDNA expression microarray evidence
GDT1 YBR187W Calcium and manganese transporter with higher affinity for Ca2+ regulation 1 1 1 DNA to cDNA expression microarray evidence
CHA1 YCL064C Catabolic L-serine (L-threonine) deaminase regulation 1 1 1 DNA to cDNA expression microarray evidence
NFG1 YLR042C Cell wall protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
VPS36 YLR417W Component of the ESCRT-II complex regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
PHO81 YGR233C Cyclin-dependent kinase (CDK) inhibitor regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
ALD6 YPL061W Cytosolic aldehyde dehydrogenase regulation 1 1 1 DNA to cDNA expression microarray evidence
DFR1 YOR236W Dihydrofolate reductase involved in tetrahydrofolate biosynthesis regulation 1 1 1 DNA to cDNA expression microarray evidence
YGR176W YGR176W Dubious open reading frame regulation 1 1 1 DNA to cDNA expression microarray evidence
YGR259C YGR259C Dubious open reading frame regulation 1 1 1 DNA to cDNA expression microarray evidence
YLR463C YLR463C Dubious open reading frame regulation 1 1 1 DNA to cDNA expression microarray evidence
YLR041W YLR041W Dubious open reading frame regulation 1 1 1 DNA to cDNA expression microarray evidence
YLR232W YLR232W Dubious open reading frame regulation 1 1 1 DNA to cDNA expression microarray evidence
YKL177W YKL177W Dubious open reading frame regulation 1 1 1 DNA to cDNA expression microarray evidence
YBR116C YBR116C Dubious open reading frame regulation 1 1 1 DNA to cDNA expression microarray evidence
YPR059C YPR059C Dubious open reading frame regulation 1 1 1 DNA to cDNA expression microarray evidence
ELO1 YJL196C Elongase I, medium-chain acyl elongase regulation 1 1 1 DNA to cDNA expression microarray evidence
COS2 YBR302C Endosomal protein involved in turnover of plasma membrane proteins regulation 1 1 1 DNA to cDNA expression microarray evidence
COS4 YFL062W Endosomal protein involved in turnover of plasma membrane proteins regulation 1 1 1 DNA to cDNA expression microarray evidence
SST2 YLR452C GTPase-activating protein for Gpa1p regulation 1 1 1 DNA to cDNA expression microarray evidence
HPF1 YOL155C Haze-protective mannoprotein regulation 1 1 1 DNA to cDNA expression microarray evidence
YRF1-4 YLR466W Helicase encoded by the Y' element of subtelomeric regions regulation 1 1 1 DNA to cDNA expression microarray evidence
YRF1-6 YNL339C Helicase encoded by the Y' element of subtelomeric regions regulation 1 1 1 DNA to cDNA expression microarray evidence
YRF1-7 YPL283C Helicase encoded by the Y' element of subtelomeric regions regulation 1 1 1 DNA to cDNA expression microarray evidence
YHR218W YHR218W Helicase-like protein encoded within the telomeric Y' element regulation 1 1 1 DNA to cDNA expression microarray evidence
YBL113C YBL113C Helicase-like protein encoded within the telomeric Y' element regulation 1 1 1 DNA to cDNA expression microarray evidence
YFL066C YFL066C Helicase-like protein encoded within the telomeric Y' element regulation 1 1 1 DNA to cDNA expression microarray evidence
YBL111C YBL111C Helicase-like protein encoded within the telomeric Y' element regulation 1 1 1 DNA to cDNA expression microarray evidence
PHO84 YML123C High-affinity inorganic phosphate (Pi) transporter regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
TNA1 YGR260W High affinity nicotinic acid plasma membrane permease regulation 1 1 1 DNA to cDNA expression microarray evidence
BNA5 YLR231C Kynureninase regulation 1 1 1 DNA to cDNA expression microarray evidence
BNA4 YBL098W Kynurenine 3-monooxygenase regulation 1 1 1 DNA to cDNA expression microarray evidence
SRL1 YOR247W Mannoprotein that exhibits a tight association with the cell wall regulation 1 1 1 DNA to cDNA expression microarray evidence
FIT2 YOR382W Mannoprotein that is incorporated into the cell wall regulation 1 1 1 DNA to cDNA expression microarray evidence
FIT3 YOR383C Mannoprotein that is incorporated into the cell wall regulation 1 1 1 DNA to cDNA expression microarray evidence
AFB1 YLR040C MATalpha-specific a-factor blocker regulation 1 1 1 DNA to cDNA expression microarray evidence
MFA1 YDR461W Mating pheromone a-factor regulation 1 1 1 DNA to cDNA expression microarray evidence
MF(ALPHA)2 YGL089C Mating pheromone alpha-factor, made by alpha cells regulation 1 1 1 DNA to cDNA expression microarray evidence
HOP2 YGL033W Meiosis-specific protein that localizes to chromosomes regulation 1 1 1 DNA to cDNA expression microarray evidence
PAU1 YJL223C Member of the seripauperin multigene family regulation 1 1 1 DNA to cDNA expression microarray evidence
FUS1 YCL027W Membrane protein localized to the shmoo tip regulation 1 1 1 DNA to cDNA expression microarray evidence
AIF1 YNR074C Mitochondrial cell death effector regulation 1 1 1 DNA to cDNA expression microarray evidence
SPP381 YBR152W mRNA splicing factor, component of U4/U6.U5 tri-snRNP regulation 1 1 1 DNA to cDNA expression microarray evidence
NIT3 YLR351C Nit protein regulation 1 1 1 DNA to cDNA expression microarray evidence
YHB1 YGR234W Nitric oxide oxidoreductase regulation 1 1 1 DNA to cDNA expression microarray evidence
PHO11 YAR071W One of three repressible acid phosphatases regulation 1 1 1 DNA to cDNA expression microarray evidence
PHO12 YHR215W One of three repressible acid phosphatases regulation 1 1 1 DNA to cDNA expression microarray evidence
ATG2 YNL242W Peripheral membrane protein required for autophagic vesicle formation regulation 1 1 1 DNA to cDNA expression microarray evidence
ERG8 YMR220W Phosphomevalonate kinase regulation 1 1 1 DNA to cDNA expression microarray evidence
SYG1 YIL047C Plasma membrane protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
SSU1 YPL092W Plasma membrane sulfite pump involved in sulfite metabolism regulation 1 1 1 DNA to cDNA expression microarray evidence
ERV15 YBR210W Protein involved in export of proteins from the endoplasmic reticulum regulation 1 1 1 DNA to cDNA expression microarray evidence
FEX2 YPL279C Protein involved in fluoride export regulation 1 1 1 DNA to cDNA expression microarray evidence
FEX1 YOR390W Protein involved in fluoride export regulation 1 1 1 DNA to cDNA expression microarray evidence
PHM6 YDR281C Protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
ULI1 YFR026C Protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
PAU14 YIL176C Protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
PAU18 YLL064C Protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
PAU20 YOL161C Protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
CSS1 YIL169C Protein of unknown function, secreted when constitutively expressed regulation 1 1 1 DNA to cDNA expression microarray evidence
HMS2 YJR147W Protein with similarity to heat shock transcription factors regulation 1 1 1 DNA to cDNA expression microarray evidence
TIR2 YOR010C Putative cell wall mannoprotein regulation 1 1 1 DNA to cDNA expression microarray evidence
CIR2 YOR356W Putative ortholog of human ETF-dH regulation 1 1 1 DNA to cDNA expression microarray evidence
YLL053C YLL053C Putative protein regulation 1 1 1 DNA to cDNA expression microarray evidence
YEL076C-A YEL076C-A Putative protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
YFL064C YFL064C Putative protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
YHL049C YHL049C Putative protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
YNL146W YNL146W Putative protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
YLR464W YLR464W Putative protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
YHL050C YHL050C Putative protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
YFL068W YFL068W Putative protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
YDL241W YDL241W Putative protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
YHR219W YHR219W Putative protein of unknown function with similarity to helicases regulation 1 1 1 DNA to cDNA expression microarray evidence
YLR462W YLR462W Putative protein of unknown function with similarity to helicases regulation 1 1 1 DNA to cDNA expression microarray evidence
YML133C YML133C Putative Y' element ATP-dependent helicase regulation 1 1 1 DNA to cDNA expression microarray evidence
BNA6 YFR047C Quinolinate phosphoribosyl transferase regulation 1 1 1 DNA to cDNA expression microarray evidence
STE3 YKL178C Receptor for a factor pheromone regulation 1 1 1 DNA to cDNA expression microarray evidence
STE2 YFL026W Receptor for alpha-factor pheromone regulation 1 1 1 DNA to cDNA expression microarray evidence
PHO5 YBR093C Repressible acid phosphatase regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
YIL082W YIL082W Retrotransposon TYA Gag gene co-transcribed with TYB Pol regulation 1 1 1 DNA to cDNA expression microarray evidence
SCS7 YMR272C Sphingolipid alpha-hydroxylase regulation 1 1 1 DNA to cDNA expression microarray evidence
GPA1 YHR005C Subunit of G protein involved in pheromone response regulation 1 1 1 DNA to cDNA expression microarray evidence
PYP1 YNL010W Sugar alcohol phosphatase regulation 1 1 1 DNA to cDNA expression microarray evidence
WTM2 YOR229W Transcriptional modulator regulation 1 1 1 DNA to cDNA expression microarray evidence
ATG8 YBL078C Ub-like protein regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
APE1 YKL103C Vacuolar aminopeptidase yscI regulation 1 1 1 DNA to cDNA expression microarray evidence
VCX1 YDL128W Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity regulation 1 1 1 DNA to cDNA expression microarray evidence
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 1 1 1 Synthetic Lethality
TAF10 YDR167W Subunit (145 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
SRB5 YGR104C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
HPR1 YDR138W Subunit of THO/TREX complexes physical 1 1 1 Affinity Capture-Western
HPR1 YDR138W Subunit of THO/TREX complexes genetic 1 1 1 Synthetic Growth Defect
TFG2 YGR005C TFIIF (Transcription Factor II) middle subunit genetic 1 1 1 Negative Genetic
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 1 1 1 Synthetic Growth Defect
SUA7 YPR086W Transcription factor TFIIB genetic 1 1 1 Negative Genetic
RPB2 YOR151C RNA polymerase II second largest subunit B150 genetic 1 1 1 Synthetic Lethality
SPT15 YER148W TATA-binding protein (TBP) genetic 1 1 1 Synthetic Lethality
STM1 YLR150W Protein required for optimal translation under nutrient stress physical 1 1 1 Affinity Capture-MS
STM1 YLR150W Protein required for optimal translation under nutrient stress genetic 1 1 1 Negative Genetic
SRP1 YNL189W Karyopherin alpha homolog physical 1 1 1 Affinity Capture-MS
SRP1 YNL189W Karyopherin alpha homolog genetic 1 1 1 Synthetic Lethality
PDB1 YBR221C E1 beta subunit of the pyruvate dehydrogenase (PDH) complex physical 1 1 1 Affinity Capture-MS
NQM1 YGR043C Transaldolase of unknown function physical 1 1 1 Affinity Capture-MS
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes physical 1 1 1 Affinity Capture-MS
FOL3 YMR113W Dihydrofolate synthetase, involved in folic acid biosynthesis physical 1 1 1 Affinity Capture-MS
FOL3 YMR113W Dihydrofolate synthetase, involved in folic acid biosynthesis genetic 1 1 1 Synthetic Lethality
SPC98 YNL126W Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex physical 1 1 1 Affinity Capture-MS
RUP1 YOR138C Protein that regulates ubiquitination of Rsp5p physical 1 1 1 Affinity Capture-MS
SRP68 YPL243W Core component of the signal recognition particle (SRP) complex physical 1 1 1 Affinity Capture-MS
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
PHO4 YFR034C Basic helix-loop-helix (bHLH) transcription factor of the myc-family physical 1 1 1 Affinity Capture-MS
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SSN3 YPL042C Component of the RNA polymerase II mediator complex physical 1 1 1 PCA
TUP1 YCR084C General repressor of transcription in complex with Cyc8p physical 1 1 1 PCA
YEF3 YLR249W Translation elongation factor 3 physical 1 1 1 Protein-RNA
PMA1 YGL008C Plasma membrane P2-type H+-ATPase physical 1 1 1 Protein-RNA
SLT2 YHR030C Serine/threonine MAP kinase physical 1 1 1 Affinity Capture-Western
HHF1 YBR009C Histone H4 physical 1 1 1 Affinity Capture-MS
HHF2 YNL030W Histone H4 physical 1 1 1 Affinity Capture-MS
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
VMA21 YGR105W Integral membrane protein required for V-ATPase function physical 1 1 1 Affinity Capture-MS
RPC10 YHR143W-A RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III physical 1 1 1 Affinity Capture-MS
RPB9 YGL070C RNA polymerase II subunit B12.6 physical 1 1 1 Affinity Capture-MS
RPB4 YJL140W RNA polymerase II subunit B32 physical 1 1 1 Affinity Capture-MS
RPB7 YDR404C RNA polymerase II subunit B16 physical 1 1 1 Affinity Capture-MS
RPB7 YDR404C RNA polymerase II subunit B16 genetic 1 1 1 Synthetic Lethality
RPB10 YOR210W RNA polymerase subunit ABC10-beta physical 1 1 1 Affinity Capture-MS
RPB10 YOR210W RNA polymerase subunit ABC10-beta genetic 1 1 1 Negative Genetic
RPO26 YPR187W RNA polymerase subunit ABC23 physical 1 1 1 Affinity Capture-MS
RPB5 YBR154C RNA polymerase subunit ABC27 physical 1 1 1 Affinity Capture-MS
RPB5 YBR154C RNA polymerase subunit ABC27 genetic 1 1 1 Negative Genetic
RPB8 YOR224C RNA polymerase subunit ABC14.5 physical 1 1 1 Affinity Capture-MS
TFG1 YGR186W TFIIF (Transcription Factor II) largest subunit physical 1 1 1 Affinity Capture-MS
TAF14 YPL129W Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes physical 1 1 1 Affinity Capture-MS
RTR1 YER139C Dual specificity protein phosphatase physical 1 1 1 Affinity Capture-MS
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
CRT10 YOL063C Protein required for the degradation of mutant 25S rRNAs physical 1 1 1 Affinity Capture-MS
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
INO80 YGL150C Nucleosome spacing factor physical 1 1 1 Affinity Capture-MS
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member physical 1 1 1 Affinity Capture-MS
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription physical 1 1 1 Reconstituted Complex
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-RNA
PUF4 YGL014W Member of the PUF protein family genetic 1 1 1 Negative Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
KRR1 YCL059C Nucleolar protein required for rRNA synthesis and ribosomal assembly physical 1 1 1 Affinity Capture-MS
ECM16 YMR128W Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP physical 1 1 1 Affinity Capture-MS
UTP10 YJL109C Nucleolar protein physical 1 1 1 Affinity Capture-MS
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
RET1 YOR207C Second-largest subunit of RNA polymerase III physical 1 1 1 Affinity Capture-MS
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family physical 1 1 1 Affinity Capture-MS
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
SIS1 YNL007C Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p physical 1 1 1 Affinity Capture-MS
SUB2 YDL084W Component of the TREX complex required for nuclear mRNA export genetic 1 1 1 Dosage Rescue
SPP1 YPL138C Subunit of COMPASS (Set1C) genetic 1 1 1 Synthetic Growth Defect
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Synthetic Lethality
NRD1 YNL251C RNA-binding subunit of Nrd1 complex genetic 1 1 1 Synthetic Lethality
CTK2 YJL006C Beta subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Synthetic Growth Defect
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 1 1 1 Negative Genetic
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 1 1 1 Negative Genetic
COG8 YML071C Component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
VPH2 YKL119C Integral membrane protein required for V-ATPase function genetic 1 1 1 Negative Genetic
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
PGD1 YGL025C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SPT4 YGR063C Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 1 1 1 Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Negative Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Negative Genetic
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 1 1 1 Negative Genetic
RIM1 YCR028C-A ssDNA-binding protein essential for mitochondrial genome maintenance genetic 1 1 1 Negative Genetic
MSI1 YBR195C Subunit of chromatin assembly factor I (CAF-1) genetic 1 1 1 Negative Genetic
MUB1 YMR100W MYND domain-containing protein genetic 1 1 1 Negative Genetic
ENV11 YGR071C Protein proposed to be involved in vacuolar functions genetic 1 1 1 Negative Genetic
SRL2 YLR082C Protein of unknown function genetic 1 1 1 Negative Genetic
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
NHP6A YPR052C High-mobility group (HMG) protein genetic 1 1 1 Negative Genetic
RAD59 YDL059C Protein involved DNA double-strand break repair genetic 1 1 1 Negative Genetic
MUM2 YBR057C Protein essential for meiotic DNA replication and sporulation genetic 1 1 1 Negative Genetic
DDC1 YPL194W DNA damage checkpoint protein genetic 1 1 1 Negative Genetic
SAS4 YDR181C Subunit of the SAS complex (Sas2p, Sas4p, Sas5p) genetic 1 1 1 Negative Genetic
RBL2 YOR265W Protein involved in microtubule morphogenesis genetic 1 1 1 Negative Genetic
PSH1 YOL054W E3 ubiquitin ligase targeting centromere-binding protein Cse4p genetic 1 1 1 Negative Genetic
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE genetic 1 1 1 Positive Genetic
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 1 1 1 Positive Genetic
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 1 1 1 Positive Genetic
ULS1 YOR191W Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) genetic 1 1 1 Positive Genetic
TDP1 YBR223C Tyrosyl-DNA phosphodiesterase I genetic 1 1 1 Positive Genetic
SNF11 YDR073W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Positive Genetic
HSM3 YBR272C Evolutionarily conserved 19S regulatory particle assembly-chaperone genetic 1 1 1 Positive Genetic
CLB4 YLR210W B-type cyclin involved in cell cycle progression genetic 1 1 1 Positive Genetic
THI6 YPL214C Thiamine-phosphate diphosphorylase and hydroxyethylthiazole kinase genetic 1 1 1 Positive Genetic
HST1 YOL068C NAD(+)-dependent histone deacetylase genetic 1 1 1 Positive Genetic
MEF1 YLR069C Mitochondrial elongation factor involved in translational elongation genetic 1 1 1 Negative Genetic
HCR1 YLR192C eIF3j component of translation initiation factor 3 (eIF3) genetic 1 1 1 Negative Genetic
NUP2 YLR335W Nucleoporin involved in nucleocytoplasmic transport genetic 1 1 1 Negative Genetic
SXM1 YDR395W Nuclear transport factor (karyopherin) genetic 1 1 1 Negative Genetic
CWC21 YDR482C Protein involved in RNA splicing by the spliceosome genetic 1 1 1 Negative Genetic
NUP170 YBL079W Subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
SKI8 YGL213C Ski complex component and WD-repeat protein genetic 1 1 1 Negative Genetic
NUP120 YKL057C Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
GCN3 YKR026C Alpha subunit of translation initiation factor eIF2B genetic 1 1 1 Negative Genetic
SGN1 YIR001C Cytoplasmic RNA-binding protein genetic 1 1 1 Negative Genetic
PDL32 YMR087W Putative ADP-ribose-1''-monophosphatase genetic 1 1 1 Negative Genetic
STO1 YMR125W Large subunit of the nuclear mRNA cap-binding protein complex genetic 1 1 1 Negative Genetic
YME2 YMR302C Integral inner mitochondrial membrane protein genetic 1 1 1 Negative Genetic
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites genetic 1 1 1 Negative Genetic
TAN1 YGL232W Putative tRNA acetyltransferase genetic 1 1 1 Negative Genetic
MRM2 YGL136C Mitochondrial 2' O-ribose methyltransferase genetic 1 1 1 Negative Genetic
MSM1 YGR171C Mitochondrial methionyl-tRNA synthetase (MetRS) genetic 1 1 1 Negative Genetic
LTV1 YKL143W Subunit of the EGO/GSE complex genetic 1 1 1 Negative Genetic
ESL2 YKR096W hEST1A/B (SMG5/6)-like protein genetic 1 1 1 Negative Genetic
IFM1 YOL023W Mitochondrial translation initiation factor 2 genetic 1 1 1 Negative Genetic
TUF1 YOR187W Mitochondrial translation elongation factor Tu (EF-Tu) genetic 1 1 1 Negative Genetic
MRM1 YOR201C Ribose methyltransferase genetic 1 1 1 Negative Genetic
MSK1 YNL073W Mitochondrial lysine-tRNA synthetase genetic 1 1 1 Negative Genetic
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MSD1 YPL104W Mitochondrial aspartyl-tRNA synthetase genetic 1 1 1 Negative Genetic
SUV3 YPL029W ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
MSS18 YPR134W Nuclear encoded protein needed for splicing of mitochondrial intron genetic 1 1 1 Negative Genetic
YCR016W YCR016W Putative protein of unknown function genetic 1 1 1 Positive Genetic
RSA3 YLR221C Protein with a likely role in ribosomal maturation genetic 1 1 1 Positive Genetic
RPA14 YDR156W RNA polymerase I subunit A14 genetic 1 1 1 Positive Genetic
EDC1 YGL222C RNA-binding protein that activates mRNA decapping directly genetic 1 1 1 Positive Genetic
SLX9 YGR081C Protein required for pre-rRNA processing genetic 1 1 1 Positive Genetic
KAP123 YER110C Karyopherin beta genetic 1 1 1 Positive Genetic
TIF1 YKR059W Translation initiation factor eIF4A genetic 1 1 1 Positive Genetic
TRM10 YOL093W tRNA methyltransferase genetic 1 1 1 Positive Genetic
PIH1 YHR034C Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1) genetic 1 1 1 Positive Genetic
TRA1 YHR099W Subunit of SAGA and NuA4 histone acetyltransferase complexes genetic 1 1 1 Synthetic Growth Defect
RAD7 YJR052W Nucleotide excision repair (NER) protein genetic 1 1 1 Synthetic Lethality
PHO85 YPL031C Cyclin-dependent kinase genetic 1 1 1 Dosage Lethality
SNU23 YDL098C Component of the U4/U6.U5 snRNP complex genetic 1 1 1 Negative Genetic
RLI1 YDR091C Essential Fe-S protein genetic 1 1 1 Negative Genetic
SSY1 YDR160W Component of the SPS plasma membrane amino acid sensor system genetic 1 1 1 Negative Genetic
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex genetic 1 1 1 Positive Genetic
UBC8 YEL012W Ubiquitin-conjugating enzyme that regulates gluconeogenesis genetic 1 1 1 Negative Genetic
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Positive Genetic
WBP1 YEL002C Beta subunit of the oligosaccharyl transferase glycoprotein complex genetic 1 1 1 Positive Genetic
NIC96 YFR002W Linker nucleoporin component of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
HEM2 YGL040C Aminolevulinate dehydratase genetic 1 1 1 Negative Genetic
RKR1 YMR247C RING domain E3 ubiquitin ligase genetic 1 1 1 Synthetic Growth Defect
ERG25 YGR060W C-4 methyl sterol oxidase genetic 1 1 1 Negative Genetic
DED81 YHR019C Cytosolic asparaginyl-tRNA synthetase genetic 1 1 1 Negative Genetic
RRF1 YHR038W Mitochondrial ribosome recycling factor genetic 1 1 1 Negative Genetic
SPT6 YGR116W Nucleosome remodeling protein genetic 1 1 1 Synthetic Lethality
QCR8 YJL166W Subunit 8 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Negative Genetic
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 1 1 1 Negative Genetic
RPS30A YLR287C-A Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
EXG1 YLR300W Major exo-1,3-beta-glucanase of the cell wall genetic 1 1 1 Negative Genetic
FCY21 YER060W Putative purine-cytosine permease genetic 1 1 1 Positive Genetic
EOS1 YNL080C Protein involved in N-glycosylation genetic 1 1 1 Positive Genetic
NAT4 YMR069W N alpha-acetyl-transferase genetic 1 1 1 Negative Genetic
SWP1 YMR149W Delta subunit of the oligosaccharyl transferase glycoprotein complex genetic 1 1 1 Negative Genetic
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p genetic 1 1 1 Negative Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 1 1 1 Positive Genetic
RPC19 YNL113W RNA polymerase subunit AC19 genetic 1 1 1 Negative Genetic
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 1 1 1 Positive Genetic
HRR25 YPL204W Conserved casein kinase, monopolin subunit genetic 1 1 1 Negative Genetic
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 1 1 1 Synthetic Growth Defect
NAT1 YDL040C Subunit of protein N-terminal acetyltransferase NatA genetic 1 1 1 Synthetic Growth Defect
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Synthetic Lethality
RAD18 YCR066W E3 ubiquitin ligase genetic 1 1 1 Synthetic Growth Defect
ELP6 YMR312W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Synthetic Growth Defect
ELP4 YPL101W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Synthetic Growth Defect
ELP3 YPL086C Subunit of Elongator complex genetic 1 1 1 Synthetic Growth Defect
MTM1 YGR257C Mitochondrial protein of the mitochondrial carrier family genetic 1 1 1 Synthetic Growth Defect
RVB2 YPL235W ATP-dependent DNA helicase, also known as reptin genetic 1 1 1 Synthetic Growth Defect
ELO3 YLR372W Elongase genetic 1 1 1 Synthetic Rescue
RNH1 YMR234W Ribonuclease H1 genetic 1 1 1 Phenotypic Suppression
PAM16 YJL104W Subunit of the import motor (PAM complex) genetic 1 1 1 Synthetic Growth Defect
RIA1 YNL163C Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis genetic 1 1 1 Synthetic Growth Defect
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 1 1 1 Synthetic Growth Defect
NAP1 YKR048C Histone chaperone and assembly chaperone for Rps6a/b genetic 1 1 1 Synthetic Rescue
EFB1 YAL003W Translation elongation factor 1 beta genetic 1 1 1 Synthetic Lethality
POP5 YAL033W Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Synthetic Lethality
PTA1 YAL043C Subunit of holo-CPF genetic 1 1 1 Synthetic Lethality
UTP20 YBL004W Component of the small-subunit (SSU) processome genetic 1 1 1 Synthetic Lethality
POP8 YBL018C Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Synthetic Lethality
MCM2 YBL023C Protein involved in DNA replication genetic 1 1 1 Synthetic Lethality
RPL32 YBL092W Ribosomal 60S subunit protein L32 genetic 1 1 1 Synthetic Lethality
IPP1 YBR011C Cytoplasmic inorganic pyrophosphatase (PPase) genetic 1 1 1 Synthetic Lethality
TSC3 YBR058C-A Protein that stimulates the activity of serine palmitoyltransferase genetic 1 1 1 Synthetic Lethality
TFC1 YBR123C Subunit of RNA polymerase III transcription initiation factor complex genetic 1 1 1 Synthetic Lethality
POP7 YBR167C Subunit of RNase MRP, nuclear RNase P and telomerase genetic 1 1 1 Synthetic Lethality
PGI1 YBR196C Glycolytic enzyme phosphoglucose isomerase genetic 1 1 1 Synthetic Lethality
ENP1 YBR247C Protein associated with U3 and U14 snoRNAs genetic 1 1 1 Synthetic Lethality
TRS20 YBR254C Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Synthetic Lethality
TSC10 YBR265W 3-ketosphinganine reductase genetic 1 1 1 Synthetic Lethality
NFS1 YCL017C Cysteine desulfurase involved in iron-sulfur cluster biogenesis genetic 1 1 1 Synthetic Lethality
LUC7 YDL087C Essential protein associated with the U1 snRNP complex genetic 1 1 1 Synthetic Lethality
RRP42 YDL111C Exosome non-catalytic core component genetic 1 1 1 Synthetic Lethality
NOP14 YDL148C Nucleolar protein genetic 1 1 1 Synthetic Lethality
SEC31 YDL195W Component of the Sec13p-Sec31p complex of the COPII vesicle coat genetic 1 1 1 Synthetic Lethality
YPD1 YDL235C Osmotic stress-responsive phosphorelay intermediate sensor protein genetic 1 1 1 Synthetic Lethality
PSF1 YDR013W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 1 1 1 Synthetic Lethality
HEM13 YDR044W Coproporphyrinogen III oxidase genetic 1 1 1 Synthetic Lethality
RPC11 YDR045C RNA polymerase III subunit C11 genetic 1 1 1 Synthetic Lethality
HEM12 YDR047W Uroporphyrinogen decarboxylase genetic 1 1 1 Synthetic Lethality
TPI1 YDR050C Triose phosphate isomerase, abundant glycolytic enzyme genetic 1 1 1 Synthetic Lethality
STN1 YDR082W Telomere end-binding and capping protein genetic 1 1 1 Synthetic Lethality
SLU7 YDR088C RNA splicing factor genetic 1 1 1 Synthetic Lethality
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 1 1 1 Synthetic Lethality
HTB1 YDR224C Histone H2B genetic 1 1 1 Synthetic Lethality
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer genetic 1 1 1 Synthetic Lethality
CIA1 YDR267C Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Synthetic Lethality
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Synthetic Lethality
YCG1 YDR325W Subunit of the condensin complex genetic 1 1 1 Synthetic Lethality
KEI1 YDR367W Component of inositol phosphorylceramide (IPC) synthase genetic 1 1 1 Synthetic Lethality
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein genetic 1 1 1 Synthetic Lethality
TIF35 YDR429C eIF3g subunit of the eukaryotic translation initiation factor 3 (eIF3) genetic 1 1 1 Synthetic Lethality
LCD1 YDR499W Essential protein required for the DNA integrity checkpoint pathways genetic 1 1 1 Synthetic Lethality
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Synthetic Lethality
PCM1 YEL058W Essential N-acetylglucosamine-phosphate mutase genetic 1 1 1 Synthetic Lethality
PRE1 YER012W Beta 4 subunit of the 20S proteasome genetic 1 1 1 Synthetic Lethality
SPC25 YER018C Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Synthetic Lethality
RPN3 YER021W Essential non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Synthetic Lethality
SRB4 YER022W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Lethality
PRO3 YER023W Delta 1-pyrroline-5-carboxylate reductase genetic 1 1 1 Synthetic Lethality
SEC4 YFL005W Rab family GTPase genetic 1 1 1 Synthetic Lethality
FRS2 YFL022C Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase genetic 1 1 1 Synthetic Lethality
YPT1 YFL038C Rab family GTPase genetic 1 1 1 Synthetic Lethality
RSC8 YFR037C Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Lethality
RET2 YFR051C Delta subunit of the coatomer complex (COPI) genetic 1 1 1 Synthetic Lethality
ERG26 YGL001C C-3 sterol dehydrogenase genetic 1 1 1 Synthetic Lethality
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l genetic 1 1 1 Synthetic Lethality
RNA15 YGL044C Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Synthetic Lethality
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Synthetic Lethality
SPC105 YGL093W Subunit of a kinetochore-microtubule binding complex genetic 1 1 1 Synthetic Lethality
TAF6 YGL112C Subunit (60 kDa) of TFIID and SAGA complexes genetic 1 1 1 Synthetic Lethality
PRP43 YGL120C RNA helicase in the DEAH-box family genetic 1 1 1 Synthetic Lethality
VRG4 YGL225W Golgi GDP-mannose transporter genetic 1 1 1 Synthetic Lethality
PRP18 YGR006W Splicing factor and component of snRNP U5 genetic 1 1 1 Synthetic Lethality
SMD1 YGR074W Core Sm protein Sm D1 genetic 1 1 1 Synthetic Lethality
PRP38 YGR075C Unique component of the U4/U6.U5 tri-snRNP particle genetic 1 1 1 Synthetic Lethality
UTP22 YGR090W Component of the small-subunit processome genetic 1 1 1 Synthetic Lethality
RRP46 YGR095C Exosome non-catalytic core component genetic 1 1 1 Synthetic Lethality
NOP7 YGR103W Component of several different pre-ribosomal particles genetic 1 1 1 Synthetic Lethality
MTR3 YGR158C Exosome non-catalytic core component genetic 1 1 1 Synthetic Lethality
GPI1 YGR216C Membrane protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Synthetic Lethality
CWC22 YGR278W Spliceosome-associated protein that is required for pre-mRNA splicing genetic 1 1 1 Synthetic Lethality
RPS20 YHL015W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Lethality
ERG11 YHR007C Lanosterol 14-alpha-demethylase genetic 1 1 1 Synthetic Lethality
RPP1 YHR062C Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Synthetic Lethality
RRP4 YHR069C Exosome non-catalytic core component genetic 1 1 1 Synthetic Lethality
TRM5 YHR070W tRNA(m(1)G37)methyltransferase genetic 1 1 1 Synthetic Lethality
UTP9 YHR196W Nucleolar protein genetic 1 1 1 Synthetic Lethality
RPN2 YIL075C Subunit of the 26S proteasome genetic 1 1 1 Synthetic Lethality
SEC24 YIL109C Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat genetic 1 1 1 Synthetic Lethality
NUP159 YIL115C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Synthetic Lethality
RHO3 YIL118W Non-essential small GTPase of the Rho/Rac family of Ras-like proteins genetic 1 1 1 Synthetic Lethality
SSL2 YIL143C Component of RNA polymerase transcription factor TFIIH holoenzyme genetic 1 1 1 Synthetic Lethality
DSN1 YIR010W Essential component of the outer kinetochore MIND complex genetic 1 1 1 Synthetic Lethality
SEC11 YIR022W 18kDa catalytic subunit of the Signal Peptidase Complex (SPC) genetic 1 1 1 Synthetic Lethality
RPC17 YJL011C RNA polymerase III subunit C17 genetic 1 1 1 Synthetic Lethality
RRN7 YJL025W Component of the core factor (CF) rDNA transcription factor complex genetic 1 1 1 Synthetic Lethality
GCD14 YJL125C Subunit of tRNA (1-methyladenosine) methyltransferase genetic 1 1 1 Synthetic Lethality
TIM17 YJL143W Essential component of the TIM23 complex genetic 1 1 1 Synthetic Lethality
ILV3 YJR016C Dihydroxyacid dehydratase genetic 1 1 1 Synthetic Lethality
IPA1 YJR141W Protein implicated in pre-mRNA processing and proteasomal degradation genetic 1 1 1 Synthetic Lethality
SFT1 YKL006C-A Intra-Golgi v-SNARE genetic 1 1 1 Synthetic Lethality
PRP40 YKL012W U1 snRNP protein involved in splicing genetic 1 1 1 Synthetic Lethality
SPC42 YKL042W Central plaque component of spindle pole body (SPB) genetic 1 1 1 Synthetic Lethality
CSE4 YKL049C Centromeric histone H3-like protein genetic 1 1 1 Synthetic Lethality
RPC25 YKL144C RNA polymerase III subunit C25 genetic 1 1 1 Synthetic Lethality
SRP102 YKL154W Signal recognition particle (SRP) receptor beta subunit genetic 1 1 1 Synthetic Lethality
SNU114 YKL173W GTPase component of U5 snRNP involved in mRNA splicing via spliceosome genetic 1 1 1 Synthetic Lethality
MTR2 YKL186C mRNA transport regulator genetic 1 1 1 Synthetic Lethality
SDS22 YKL193C Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p genetic 1 1 1 Synthetic Lethality
MIA40 YKL195W Import and assembly protein in mitochondrial intermembrane space genetic 1 1 1 Synthetic Lethality
RSC4 YKR008W Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Lethality
SPC34 YKR037C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Synthetic Lethality
TFA2 YKR062W TFIIE small subunit genetic 1 1 1 Synthetic Lethality
LAS1 YKR063C Endonuclease involved in pre-rRNA processing at both ends of ITS2 genetic 1 1 1 Synthetic Lethality
DAD2 YKR083C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Synthetic Lethality
PRP16 YKR086W DEAH-box RNA helicase genetic 1 1 1 Synthetic Lethality
GPI13 YLL031C ER membrane localized phosphoryltransferase genetic 1 1 1 Synthetic Lethality
PAM18 YLR008C Subunit of the import motor (PAM complex) genetic 1 1 1 Synthetic Lethality
SEN2 YLR105C Subunit of the tRNA splicing endonuclease genetic 1 1 1 Synthetic Lethality
RRN5 YLR141W Protein involved in transcription of rDNA by RNA polymerase I genetic 1 1 1 Synthetic Lethality
RPS31 YLR167W Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin genetic 1 1 1 Synthetic Lethality
NMT1 YLR195C N-myristoyl transferase genetic 1 1 1 Synthetic Lethality
GPN3 YLR243W Putative GTPase with a role in biogenesis of RNA pol II and polIII genetic 1 1 1 Synthetic Lethality
YCS4 YLR272C Subunit of the condensin complex genetic 1 1 1 Synthetic Lethality
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Synthetic Lethality
YHC1 YLR298C Component of the U1 snRNP complex required for pre-mRNA splicing genetic 1 1 1 Synthetic Lethality
SEC61 YLR378C Conserved ER protein translocation channel genetic 1 1 1 Synthetic Lethality
SPP382 YLR424W Essential protein that forms a dimer with Ntr2p genetic 1 1 1 Synthetic Lethality
SEN1 YLR430W ATP-dependent 5' to 3' RNA/DNA and DNA helicase genetic 1 1 1 Synthetic Lethality
SEC39 YLR440C Component of the Dsl1p tethering complex genetic 1 1 1 Synthetic Lethality
PRP39 YML046W U1 snRNP protein involved in splicing genetic 1 1 1 Synthetic Lethality
PRE8 YML092C Alpha 2 subunit of the 20S proteasome genetic 1 1 1 Synthetic Lethality
UTP14 YML093W Subunit of U3-containing Small Subunit (SSU) processome complex genetic 1 1 1 Synthetic Lethality
SEC65 YML105C Subunit of the signal recognition particle (SRP) genetic 1 1 1 Synthetic Lethality
TAF8 YML114C TFIID subunit (65 kDa) genetic 1 1 1 Synthetic Lethality
ERG29 YMR134W Protein of unknown function involved in ergosterol biosynthesis genetic 1 1 1 Synthetic Lethality
ROT1 YMR200W Molecular chaperone involved in protein folding in ER genetic 1 1 1 Synthetic Lethality
CEF1 YMR213W Essential splicing factor genetic 1 1 1 Synthetic Lethality
ERG8 YMR220W Phosphomevalonate kinase genetic 1 1 1 Synthetic Lethality
TAF7 YMR227C TFIID subunit (67 kDa) genetic 1 1 1 Synthetic Lethality
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes genetic 1 1 1 Synthetic Lethality
TIF11 YMR260C Translation initiation factor eIF1A genetic 1 1 1 Synthetic Lethality
HSH155 YMR288W U2-snRNP associated splicing factor genetic 1 1 1 Synthetic Lethality
LIP1 YMR298W Ceramide synthase subunit genetic 1 1 1 Synthetic Lethality
PSE1 YMR308C Karyopherin/importin that interacts with the nuclear pore complex genetic 1 1 1 Synthetic Lethality
PRE5 YMR314W Alpha 6 subunit of the 20S proteasome genetic 1 1 1 Synthetic Lethality
LST8 YNL006W Protein required for the transport of Gap1p genetic 1 1 1 Synthetic Lethality
GPI15 YNL038W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Synthetic Lethality
IMP4 YNL075W Component of the SSU processome genetic 1 1 1 Synthetic Lethality
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Synthetic Lethality
TOM22 YNL131W Component of the TOM (Translocase of Outer Membrane) complex genetic 1 1 1 Synthetic Lethality
NAR1 YNL240C Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery genetic 1 1 1 Synthetic Lethality
SUI1 YNL244C Translation initiation factor eIF1 genetic 1 1 1 Synthetic Lethality
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Synthetic Lethality
SEC21 YNL287W Gamma subunit of coatomer genetic 1 1 1 Synthetic Lethality
MRPS18 YNL306W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Synthetic Lethality
ZIM17 YNL310C Protein co-chaperone with a zinc finger motif genetic 1 1 1 Synthetic Lethality
RPC34 YNR003C RNA polymerase III subunit C34 genetic 1 1 1 Synthetic Lethality
TIM23 YNR017W Essential component of the TIM23 complex genetic 1 1 1 Synthetic Lethality
DBP6 YNR038W Essential protein involved in ribosome biogenesis genetic 1 1 1 Synthetic Lethality
TRM112 YNR046W Protein involved in methylation of tRNA, rRNA, and translation factors genetic 1 1 1 Synthetic Lethality
TSR4 YOL022C Cytoplasmic assembly chaperone for ribosomal protein Rps2p genetic 1 1 1 Synthetic Lethality
PRE6 YOL038W Alpha 4 subunit of the 20S proteasome genetic 1 1 1 Synthetic Lethality
RIB2 YOL066C Bifunctional DRAP deaminase tRNA:pseudouridine synthase genetic 1 1 1 Synthetic Lethality
NUF2 YOL069W Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Synthetic Lethality
TPT1 YOL102C tRNA 2'-phosphotransferase that catalyzes final step in tRNA splicing genetic 1 1 1 Synthetic Lethality
NOP8 YOL144W Nucleolar protein required for 60S ribosomal subunit biogenesis genetic 1 1 1 Synthetic Lethality
SLD7 YOR060C Protein with a role in chromosomal DNA replication genetic 1 1 1 Synthetic Lethality
RKI1 YOR095C Ribose-5-phosphate ketol-isomerase genetic 1 1 1 Synthetic Lethality
NUP1 YOR098C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Synthetic Lethality
PFY1 YOR122C Profilin genetic 1 1 1 Synthetic Lethality
PNO1 YOR145C Essential nucleolar protein required for pre-18S rRNA processing genetic 1 1 1 Synthetic Lethality
SPP2 YOR148C Essential protein that promotes the first step of splicing genetic 1 1 1 Synthetic Lethality
GLN4 YOR168W Glutamine tRNA synthetase genetic 1 1 1 Synthetic Lethality
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity genetic 1 1 1 Synthetic Lethality
YTM1 YOR272W Ribosomal assembly factor and 66S pre-ribosomal particle constituent genetic 1 1 1 Synthetic Lethality
PLP2 YOR281C Protein that interacts with the CCT complex to stimulate actin folding genetic 1 1 1 Synthetic Lethality
RRS1 YOR294W Essential protein that binds ribosomal protein L11 genetic 1 1 1 Synthetic Lethality
PRT1 YOR361C eIF3b subunit of the eukaryotic translation initiation factor 3 (eIF3) genetic 1 1 1 Synthetic Lethality
RET3 YPL010W Zeta subunit of the coatomer complex (COPI) genetic 1 1 1 Synthetic Lethality
ULP1 YPL020C Protease that specifically cleaves Smt3p protein conjugates genetic 1 1 1 Synthetic Lethality
ERG10 YPL028W Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) genetic 1 1 1 Synthetic Lethality
NOP4 YPL043W Nucleolar protein genetic 1 1 1 Synthetic Lethality
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Synthetic Lethality
SEN54 YPL083C Subunit of the tRNA splicing endonuclease genetic 1 1 1 Synthetic Lethality
SEC62 YPL094C Essential subunit of Sec63 complex genetic 1 1 1 Synthetic Lethality
TBF1 YPL128C Telobox-containing general regulatory factor genetic 1 1 1 Synthetic Lethality
SPT14 YPL175W UDP-glycosyltransferase subunit of the GPI-GnT complex genetic 1 1 1 Synthetic Lethality
DIM1 YPL266W Essential 18S rRNA dimethylase (dimethyladenosine transferase) genetic 1 1 1 Synthetic Lethality
TIF6 YPR016C Constituent of 66S pre-ribosomal particles genetic 1 1 1 Synthetic Lethality
HTS1 YPR033C Cytoplasmic and mitochondrial histidine tRNA synthetase genetic 1 1 1 Synthetic Lethality
TFB4 YPR056W Subunit of TFIIH complex genetic 1 1 1 Synthetic Lethality
DIB1 YPR082C 17-kDa component of the U4/U6aU5 tri-snRNP genetic 1 1 1 Synthetic Lethality
PRE2 YPR103W Beta 5 subunit of the 20S proteasome genetic 1 1 1 Synthetic Lethality
JIP5 YPR169W Protein required for biogenesis of the large ribosomal subunit genetic 1 1 1 Synthetic Lethality
PZF1 YPR186C Transcription factor IIIA (TFIIIA) genetic 1 1 1 Synthetic Lethality
TTI1 YKL033W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic
YOR1 YGR281W Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Negative Genetic
REB1 YBR049C RNA polymerase I enhancer binding protein genetic 1 1 1 Positive Genetic
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Positive Genetic
SRB6 YBR253W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
GPI17 YDR434W Transmembrane protein genetic 1 1 1 Positive Genetic
MCM3 YEL032W Protein involved in DNA replication genetic 1 1 1 Positive Genetic
POL5 YEL055C Protein involved in 60S assembly and pre-40S AFs recycling genetic 1 1 1 Positive Genetic
ISD11 YER048W-A Cysteine desulfurase (Nfs1p) activator genetic 1 1 1 Positive Genetic
TSC11 YER093C Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) genetic 1 1 1 Positive Genetic
RAD3 YER171W 5' to 3' DNA helicase genetic 1 1 1 Positive Genetic
RPL28 YGL103W Ribosomal 60S subunit protein L28 genetic 1 1 1 Positive Genetic
GPI10 YGL142C Integral membrane protein involved in GPI anchor synthesis genetic 1 1 1 Positive Genetic
TIP20 YGL145W Peripheral membrane protein required for COPI vesicle fusion to the ER genetic 1 1 1 Positive Genetic
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin genetic 1 1 1 Positive Genetic
PRI2 YKL045W Subunit of DNA primase genetic 1 1 1 Positive Genetic
MPE1 YKL059C Subunit of CPF cleavage and polyadenylation factor and E3 Ub-ligase genetic 1 1 1 Positive Genetic
YKT6 YKL196C Vesicle membrane protein (v-SNARE) with acyltransferase activity genetic 1 1 1 Positive Genetic
RPL10 YLR075W Ribosomal 60S subunit protein L10 genetic 1 1 1 Positive Genetic
SMC4 YLR086W Subunit of the condensin complex genetic 1 1 1 Positive Genetic
SRV2 YNL138W CAP (cyclase-associated protein) genetic 1 1 1 Positive Genetic
KRI1 YNL308C Essential nucleolar protein required for 40S ribosome biogenesis genetic 1 1 1 Positive Genetic
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family genetic 1 1 1 Positive Genetic
NOG1 YPL093W Putative GTPase genetic 1 1 1 Positive Genetic
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes genetic 1 1 1 Positive Genetic
VPS54 YDR027C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Positive Genetic
TMA64 YDR117C Protein of unknown function that associates with ribosomes genetic 1 1 1 Positive Genetic
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member genetic 1 1 1 Positive Genetic
REF2 YDR195W RNA-binding protein genetic 1 1 1 Positive Genetic
SDC1 YDR469W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Positive Genetic
YDR524C-B YDR524C-B Putative protein of unknown function genetic 1 1 1 Positive Genetic
VMA3 YEL027W Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase genetic 1 1 1 Positive Genetic
GTA1 YEL043W Protein of unknown function genetic 1 1 1 Positive Genetic
RPL12A YEL054C Ribosomal 60S subunit protein L12A genetic 1 1 1 Positive Genetic
FMP52 YER004W Protein of unknown function genetic 1 1 1 Positive Genetic
MIN10 YFR032C-B Mitochondrial protein of unknown function genetic 1 1 1 Positive Genetic
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 1 1 1 Positive Genetic
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex genetic 1 1 1 Positive Genetic
HUR1 YGL168W Protein with a role in DNA repair genetic 1 1 1 Positive Genetic
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 1 1 1 Positive Genetic
SSM4 YIL030C Membrane-embedded ubiquitin-protein ligase and retrotranslocase genetic 1 1 1 Positive Genetic
YVH1 YIR026C Dual specificity protein phosphatase genetic 1 1 1 Positive Genetic
TIF2 YJL138C Translation initiation factor eIF4A genetic 1 1 1 Positive Genetic
SOR1 YJR159W Sorbitol dehydrogenase genetic 1 1 1 Positive Genetic
DEF1 YKL054C RNAPII degradation factor genetic 1 1 1 Positive Genetic
MTC2 YKL098W Protein of unknown function genetic 1 1 1 Positive Genetic
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 1 1 1 Positive Genetic
RPS7B YNL096C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
JJJ1 YNL227C Co-chaperone that stimulates the ATPase activity of Ssa1p genetic 1 1 1 Positive Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Positive Genetic
RPA49 YNL248C RNA polymerase I subunit A49 genetic 1 1 1 Positive Genetic
MSN1 YOL116W Transcriptional activator genetic 1 1 1 Positive Genetic
YOR034C-A YOR034C-A Putative protein of unknown function genetic 1 1 1 Positive Genetic
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 1 1 1 Positive Genetic
PIN2 YOR104W Exomer-dependent cargo protein genetic 1 1 1 Positive Genetic
YPL077C YPL077C Putative protein of unknown function genetic 1 1 1 Positive Genetic
VMA13 YPR036W Subunit H of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Positive Genetic
RER2 YBR002C Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1 genetic 1 1 1 Negative Genetic
CMD1 YBR109C Calmodulin genetic 1 1 1 Negative Genetic
CTR86 YCR054C Essential protein of unknown function genetic 1 1 1 Negative Genetic
PRP11 YDL043C Subunit of the SF3a splicing factor complex genetic 1 1 1 Negative Genetic
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
SLY1 YDR189W Hydrophilic protein involved in ER/Golgi vesicle trafficking genetic 1 1 1 Negative Genetic
NSE3 YDR288W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
NCB2 YDR397C Subunit of a heterodimeric NC2 transcription regulator complex genetic 1 1 1 Negative Genetic
GUK1 YDR454C Guanylate kinase genetic 1 1 1 Negative Genetic
SNM1 YDR478W Ribonuclease MRP complex subunit genetic 1 1 1 Negative Genetic
SLD5 YDR489W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 1 1 1 Negative Genetic
RBA50 YDR527W Protein involved in transcription genetic 1 1 1 Negative Genetic
PMI40 YER003C Mannose-6-phosphate isomerase genetic 1 1 1 Negative Genetic
KRE29 YER038C Subunit of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
SAD1 YFR005C Conserved zinc-finger domain protein involved in pre-mRNA splicing genetic 1 1 1 Negative Genetic
DAM1 YGR113W Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
PTI1 YGR156W Essential component of CPF (cleavage and polyadenylation factor) genetic 1 1 1 Negative Genetic
SKI6 YGR195W Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
PUP2 YGR253C Alpha 5 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
ERG7 YHR072W Lanosterol synthase genetic 1 1 1 Negative Genetic
NMD3 YHR170W Protein involved in nuclear export of the large ribosomal subunit genetic 1 1 1 Negative Genetic
TAO3 YIL129C Component of the RAM signaling network genetic 1 1 1 Negative Genetic
NOP9 YJL010C Essential subunit of U3-containing 90S preribosome genetic 1 1 1 Negative Genetic
LSM8 YJR022W Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
SSC1 YJR045C Hsp70 family ATPase genetic 1 1 1 Negative Genetic
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 1 1 1 Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
ERG27 YLR100W 3-keto sterol reductase genetic 1 1 1 Negative Genetic
SMD2 YLR275W Core Sm protein Sm D2 genetic 1 1 1 Negative Genetic
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) genetic 1 1 1 Negative Genetic
ERG13 YML126C 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase genetic 1 1 1 Negative Genetic
RSC9 YML127W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
CTF13 YMR094W Subunit of the CBF3 complex genetic 1 1 1 Negative Genetic
CEP3 YMR168C Essential kinetochore protein genetic 1 1 1 Negative Genetic
PRP24 YMR268C Splicing factor that reanneals snRNPs during spliceosome recycling genetic 1 1 1 Negative Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
POP3 YNL282W Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Negative Genetic
MVD1 YNR043W Mevalonate pyrophosphate decarboxylase genetic 1 1 1 Negative Genetic
HSP10 YOR020C Mitochondrial matrix co-chaperonin genetic 1 1 1 Negative Genetic
UFE1 YOR075W t-SNARE protein required for retrograde vesicular traffic genetic 1 1 1 Negative Genetic
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
NOP53 YPL146C Nucleolar protein genetic 1 1 1 Negative Genetic
COG4 YPR105C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
YBR096W YBR096W Putative protein of unknown function genetic 1 1 1 Negative Genetic
CSH1 YBR161W Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Negative Genetic
ERV15 YBR210W Protein involved in export of proteins from the endoplasmic reticulum genetic 1 1 1 Negative Genetic
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers genetic 1 1 1 Negative Genetic
MAL33 YBR297W MAL-activator protein genetic 1 1 1 Negative Genetic
ILV6 YCL009C Regulatory subunit of acetolactate synthase genetic 1 1 1 Negative Genetic
YCR102C YCR102C Putative quinone oxidoreductase genetic 1 1 1 Negative Genetic
SLC1 YDL052C 1-acyl-sn-glycerol-3-phosphate acyltransferase genetic 1 1 1 Negative Genetic
COX9 YDL067C Subunit VIIa of cytochrome c oxidase (Complex IV) genetic 1 1 1 Negative Genetic
YDL157C YDL157C Putative protein of unknown function genetic 1 1 1 Negative Genetic
NSI1 YDR026C RNA polymerase I termination factor genetic 1 1 1 Negative Genetic
DET1 YDR051C Acid phosphatase genetic 1 1 1 Negative Genetic
YDR131C YDR131C F-box protein subunit of SCF ubiquitin ligase complex genetic 1 1 1 Negative Genetic
EKI1 YDR147W Ethanolamine kinase genetic 1 1 1 Negative Genetic
RAD30 YDR419W DNA polymerase eta genetic 1 1 1 Negative Genetic
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RSM28 YDR494W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
URC2 YDR520C Putative Zn(II)2Cys6 motif containing transcription factor genetic 1 1 1 Negative Genetic
GCN4 YEL009C bZIP transcriptional activator of amino acid biosynthetic genes genetic 1 1 1 Negative Genetic
SOM1 YEL059C-A Subunit of the mitochondrial inner membrane peptidase (IMP) genetic 1 1 1 Negative Genetic
MXR1 YER042W Methionine-S-sulfoxide reductase genetic 1 1 1 Negative Genetic
YER079W YER079W Putative protein of unknown function genetic 1 1 1 Negative Genetic
RPO41 YFL036W Mitochondrial RNA polymerase genetic 1 1 1 Negative Genetic
PIB2 YGL023C Phosphatidylinositol 3-phosphate binding protein genetic 1 1 1 Negative Genetic
TPN1 YGL186C Plasma membrane pyridoxine (vitamin B6) transporter genetic 1 1 1 Negative Genetic
YGL235W YGL235W Putative protein of unknown function genetic 1 1 1 Negative Genetic
XKS1 YGR194C Xylulokinase genetic 1 1 1 Negative Genetic
SNG1 YGR197C Protein involved in resistance to nitrosoguanidine and 6-azauracil genetic 1 1 1 Negative Genetic
MRPL9 YGR220C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
COX6 YHR051W Subunit VI of cytochrome c oxidase (Complex IV) genetic 1 1 1 Negative Genetic
COX23 YHR116W Protein that functions in mitochondrial copper homeostasis genetic 1 1 1 Negative Genetic
PTH1 YHR189W One of two mitochondrially-localized peptidyl-tRNA hydrolases genetic 1 1 1 Negative Genetic
HOS4 YIL112W Subunit of the Set3 complex genetic 1 1 1 Negative Genetic
COA3 YJL062W-A Mitochondrial protein required for cytochrome c oxidase assembly genetic 1 1 1 Negative Genetic
LAS21 YJL062W Mannose-ethanolamine phosphotransferase genetic 1 1 1 Negative Genetic
PIR5 YJL160C Putative protein of unknown function genetic 1 1 1 Negative Genetic
LIA1 YJR070C Deoxyhypusine hydroxylase genetic 1 1 1 Negative Genetic
MNS1 YJR131W Alpha-1,2-mannosidase genetic 1 1 1 Negative Genetic
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) genetic 1 1 1 Negative Genetic
PMT4 YJR143C Protein O-mannosyltransferase genetic 1 1 1 Negative Genetic
DID4 YKL002W Class E Vps protein of the ESCRT-III complex genetic 1 1 1 Negative Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Negative Genetic
ECM4 YKR076W S-glutathionyl-(chloro)hydroquinone reductase (GS-HQR) genetic 1 1 1 Negative Genetic
MLP1 YKR095W Myosin-like protein associated with the nuclear envelope genetic 1 1 1 Negative Genetic
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 1 1 1 Negative Genetic
COX17 YLL009C Copper metallochaperone that transfers copper to Sco1p and Cox11p genetic 1 1 1 Negative Genetic
COQ9 YLR201C Protein required for ubiquinone biosynthesis and respiratory growth genetic 1 1 1 Negative Genetic
MDM34 YGL219C Mitochondrial component of the ERMES complex genetic 1 1 1 Negative Genetic
SNF6 YHL025W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Negative Genetic
COG5 YNL051W Component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
YNL140C YNL140C Protein of unknown function genetic 1 1 1 Negative Genetic
TRM9 YML014W tRNA methyltransferase genetic 1 1 1 Negative Genetic
SML1 YML058W Ribonucleotide reductase inhibitor genetic 1 1 1 Negative Genetic
SUB1 YMR039C Transcriptional regulator genetic 1 1 1 Negative Genetic
YTA12 YMR089C Mitochondrial inner membrane m-AAA protease component genetic 1 1 1 Negative Genetic
MTG1 YMR097C Putative GTPase peripheral to the mitochondrial inner membrane genetic 1 1 1 Negative Genetic
MYO5 YMR109W One of two type I myosin motors genetic 1 1 1 Negative Genetic
ICY1 YMR195W Protein of unknown function genetic 1 1 1 Negative Genetic
FSH2 YMR222C Putative serine hydrolase that localizes to the cytoplasm genetic 1 1 1 Negative Genetic
YNL040W YNL040W Protein of unknown function genetic 1 1 1 Negative Genetic
POR1 YNL055C Mitochondrial porin (voltage-dependent anion channel) genetic 1 1 1 Negative Genetic
WSC2 YNL283C Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway genetic 1 1 1 Negative Genetic
CPR8 YNR028W Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Negative Genetic
MCH4 YOL119C Protein with similarity to mammalian monocarboxylate permeases genetic 1 1 1 Negative Genetic
YOL162W YOL162W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YOR032W-A YOR032W-A Protein of unknown function genetic 1 1 1 Negative Genetic
GYP1 YOR070C Cis-golgi GTPase-activating protein (GAP) for yeast Rabs genetic 1 1 1 Negative Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Negative Genetic
LDB19 YOR322C Alpha-arrestin, Ub-ligase adaptor for Rsp5p genetic 1 1 1 Negative Genetic
TRM44 YPL030W tRNA(Ser) Um(44) 2'-O-methyltransferase genetic 1 1 1 Negative Genetic
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
ISU1 YPL135W Conserved protein of the mitochondrial matrix genetic 1 1 1 Negative Genetic
JID1 YPR061C Probable Hsp40p co-chaperone genetic 1 1 1 Negative Genetic
CNB1 YKL190W Calcineurin B genetic 1 1 1 Negative Genetic
ICP55 YER078C Mitochondrial aminopeptidase genetic 1 1 1 Negative Genetic
SPE1 YKL184W Ornithine decarboxylase genetic 1 1 1 Positive Genetic
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 1 1 1 Negative Genetic
PPT1 YGR123C Protein serine/threonine phosphatase genetic 1 1 1 Positive Genetic
PNP1 YLR209C Purine nucleoside phosphorylase genetic 1 1 1 Negative Genetic
SAT4 YCR008W Ser/Thr protein kinase involved in salt tolerance, nutrient response genetic 1 1 1 Negative Genetic
OCT1 YKL134C Mitochondrial intermediate peptidase genetic 1 1 1 Negative Genetic
TAT2 YOL020W High affinity tryptophan and tyrosine permease genetic 1 1 1 Negative Genetic
CPR3 YML078W Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Positive Genetic
SAK1 YER129W Upstream serine/threonine kinase for the SNF1 complex genetic 1 1 1 Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Positive Genetic
ROX1 YPR065W Heme-dependent repressor of hypoxic genes genetic 1 1 1 Positive Genetic
RPS10B YMR230W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
RAM2 YKL019W Alpha subunit of farnesyltransferase and geranylgeranyltransferase-I genetic 1 1 1 Negative Genetic
ERG2 YMR202W C-8 sterol isomerase genetic 1 1 1 Positive Genetic
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting genetic 1 1 1 Negative Genetic
HMG1 YML075C HMG-CoA reductase genetic 1 1 1 Negative Genetic
SPE2 YOL052C S-adenosylmethionine decarboxylase genetic 1 1 1 Positive Genetic
URA1 YKL216W Dihydroorotate dehydrogenase genetic 1 1 1 Negative Genetic
RPS11B YBR048W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
MDL2 YPL270W Mitochondrial inner membrane half-type ABC transporter genetic 1 1 1 Positive Genetic
DNM1 YLL001W Dynamin-related GTPase involved in mitochondrial organization genetic 1 1 1 Negative Genetic
OAF1 YAL051W Oleate-activated transcription factor genetic 1 1 1 Negative Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 1 1 1 Positive Genetic
INO2 YDR123C Transcription factor genetic 1 1 1 Positive Genetic
PML1 YLR016C Subunit of the RES complex genetic 1 1 1 Negative Genetic
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
CPR6 YLR216C Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Negative Genetic
QCR2 YPR191W Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Positive Genetic
HEM25 YDL119C Mitochondrial glycine transporter genetic 1 1 1 Negative Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Negative Genetic
PKH3 YDR466W Protein kinase with similarity to mammalian PDK1 and yeast Pkh1p/Phk2p genetic 1 1 1 Positive Genetic
RPL11B YGR085C Ribosomal 60S subunit protein L11B genetic 1 1 1 Positive Genetic
YPK1 YKL126W S/T protein kinase genetic 1 1 1 Positive Genetic
OST3 YOR085W Gamma subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Positive Genetic
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Negative Genetic
MKK2 YPL140C MAPKK involved in the protein kinase C signaling pathway genetic 1 1 1 Negative Genetic
LCB5 YLR260W Minor sphingoid long-chain base kinase genetic 1 1 1 Negative Genetic
RTG2 YGL252C Sensor of mitochondrial dysfunction genetic 1 1 1 Positive Genetic
YAK1 YJL141C Serine-threonine protein kinase genetic 1 1 1 Positive Genetic
RNR2 YJL026W Ribonucleotide-diphosphate reductase (RNR), small subunit genetic 1 1 1 Negative Genetic
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II genetic 1 1 1 Negative Genetic
FUM1 YPL262W Fumarase genetic 1 1 1 Positive Genetic
NMA111 YNL123W Serine protease and general molecular chaperone genetic 1 1 1 Positive Genetic
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
HFA1 YMR207C Mitochondrial acetyl-coenzyme A carboxylase genetic 1 1 1 Negative Genetic
NRE1 YIR035C Putative cytoplasmic short-chain dehydrogenase/reductase genetic 1 1 1 Positive Genetic
PHO5 YBR093C Repressible acid phosphatase genetic 1 1 1 Positive Genetic
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 1 1 1 Negative Genetic
RPS11A YDR025W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
NHX1 YDR456W Na+/H+ and K+/H+ exchanger genetic 1 1 1 Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Positive Genetic
LPD1 YFL018C Dihydrolipoamide dehydrogenase genetic 1 1 1 Negative Genetic
COQ6 YGR255C Flavin-dependent monooxygenase involved in ubiquinone biosynthesis genetic 1 1 1 Negative Genetic
PMC1 YGL006W Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions genetic 1 1 1 Negative Genetic
GLR1 YPL091W Cytosolic and mitochondrial glutathione oxidoreductase genetic 1 1 1 Positive Genetic
GAL4 YPL248C DNA-binding transcription factor required for activating GAL genes genetic 1 1 1 Negative Genetic
RTS1 YOR014W B-type regulatory subunit of protein phosphatase 2A (PP2A) genetic 1 1 1 Negative Genetic
RPS19B YNL302C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
POM34 YLR018C Subunit of the transmembrane ring of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
CSN9 YDR179C Subunit of the Cop9 signalosome genetic 1 1 1 Negative Genetic
OCA5 YHL029C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Positive Genetic
SAM35 YHR083W Component of the sorting and assembly machinery (SAM) complex genetic 1 1 1 Negative Genetic
MUD2 YKL074C Protein involved in early pre-mRNA splicing genetic 1 1 1 Positive Genetic
ERV25 YML012W Member of the p24 family involved in ER to Golgi transport genetic 1 1 1 Positive Genetic
PET127 YOR017W Protein with a role in 5'-end processing of mitochondrial RNAs genetic 1 1 1 Positive Genetic
OPY2 YPR075C Integral membrane protein that acts as a membrane anchor for Ste50p genetic 1 1 1 Negative Genetic
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 1 1 1 Positive Genetic
SEC53 YFL045C Phosphomannomutase genetic 1 1 1 Positive Genetic
OKP1 YGR179C Outer kinetochore protein required for accurate chromosome segregation genetic 1 1 1 Negative Genetic
MVB12 YGR206W ESCRT-I subunit required to stabilize ESCRT-I core complex oligomers genetic 1 1 1 Negative Genetic
EAF6 YJR082C Subunit of the NuA4 acetyltransferase complex genetic 1 1 1 Positive Genetic
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 1 1 1 Positive Genetic
VPS36 YLR417W Component of the ESCRT-II complex genetic 1 1 1 Synthetic Growth Defect
SPS4 YOR313C Protein whose expression is induced during sporulation genetic 1 1 1 Negative Genetic
EGD2 YHR193C Alpha subunit of the nascent polypeptide-associated complex (NAC) genetic 1 1 1 Negative Genetic
YJL118W YJL118W Protein of unknown function genetic 1 1 1 Negative Genetic
ECT1 YGR007W Ethanolamine-phosphate cytidylyltransferase genetic 1 1 1 Negative Genetic
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation genetic 1 1 1 Phenotypic Enhancement
CHL4 YDR254W Outer kinetochore protein required for chromosome stability genetic 1 1 1 Phenotypic Enhancement
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 1 1 1 Phenotypic Enhancement
PCK1 YKR097W Phosphoenolpyruvate carboxykinase genetic 1 1 1 Phenotypic Enhancement
PSO2 YMR137C Nuclease required for DNA single- and double-strand break repair genetic 1 1 1 Phenotypic Enhancement
RAD24 YER173W Checkpoint protein genetic 1 1 1 Phenotypic Enhancement
RNH203 YLR154C Ribonuclease H2 subunit genetic 1 1 1 Phenotypic Enhancement
VIK1 YPL253C Protein that forms a kinesin-14 heterodimeric motor with Kar3p genetic 1 1 1 Phenotypic Enhancement
MID1 YNL291C Stretch-activated Ca2+-permeable cation channel genetic 1 1 1 Phenotypic Enhancement
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 1 1 1 Phenotypic Enhancement
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Phenotypic Enhancement
VPS20 YMR077C Myristoylated subunit of the ESCRT-III complex genetic 1 1 1 Phenotypic Enhancement
PIF1 YML061C DNA helicase, potent G-quadruplex DNA binder/unwinder genetic 1 1 1 Phenotypic Suppression
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 1 1 1 Phenotypic Enhancement
SIR3 YLR442C Silencing protein genetic 1 1 1 Phenotypic Enhancement
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains genetic 1 1 1 Phenotypic Enhancement
REC114 YMR133W Protein involved in early stages of meiotic recombination genetic 1 1 1 Phenotypic Enhancement
CDC40 YDR364C Pre-mRNA splicing factor genetic 1 1 1 Negative Genetic
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Synthetic Lethality
BRX1 YOL077C Nucleolar protein genetic 1 1 1 Synthetic Lethality
ADH1 YOL086C Alcohol dehydrogenase physical 1 1 1 Protein-RNA
CDC42 YLR229C Small rho-like GTPase genetic 1 1 1 Synthetic Lethality
BMH1 YER177W 14-3-3 protein, major isoform genetic 1 1 1 Positive Genetic
CDC33 YOL139C Translation initiation factor eIF4E genetic 1 1 1 Synthetic Lethality
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-Western
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex genetic 1 1 1 Synthetic Lethality
ACC1 YNR016C Acetyl-CoA carboxylase, biotin containing enzyme genetic 1 1 1 Positive Genetic
ARC35 YNR035C Subunit of the ARP2/3 complex genetic 1 1 1 Synthetic Lethality
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 1 1 1 Negative Genetic
BET3 YKR068C Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Synthetic Lethality
BET2 YPR176C Beta subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 1 1 1 Negative Genetic
CCA1 YER168C ATP (CTP):tRNA-specific tRNA nucleotidyltransferase genetic 1 1 1 Negative Genetic
CAF40 YNL288W Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 Affinity Capture-MS
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Synthetic Growth Defect
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Positive Genetic
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
BLM10 YFL007W Proteasome activator genetic 1 1 1 Negative Genetic
BUD21 YOR078W Component of small ribosomal subunit (SSU) processosome genetic 1 1 1 Negative Genetic
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 1 1 1 Synthetic Growth Defect
ABF2 YMR072W Mitochondrial DNA-binding protein genetic 1 1 1 Negative Genetic
CCT2 YIL142W Subunit beta of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Synthetic Lethality
CDC25 YLR310C Membrane bound guanine nucleotide exchange factor genetic 1 1 1 Synthetic Lethality
CCT8 YJL008C Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Synthetic Lethality
BRR1 YPR057W snRNP protein component of spliceosomal snRNPs genetic 1 1 1 Positive Genetic
BUR2 YLR226W Cyclin for the Sgv1p (Bur1p) protein kinase genetic 1 1 1 Synthetic Growth Defect
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
BET5 YML077W Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Negative Genetic
BRE2 YLR015W Subunit of COMPASS (Set1C) complex genetic 1 1 1 Positive Genetic
ATG12 YBR217W Ubiquitin-like modifier involved in autophagy and the Cvt pathway genetic 1 1 1 Negative Genetic
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Synthetic Lethality
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 1 1 1 Synthetic Lethality
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network genetic 1 1 1 Negative Genetic
ARE1 YCR048W Acyl-CoA:sterol acyltransferase genetic 1 1 1 Positive Genetic
ATE1 YGL017W Arginyl-tRNA-protein transferase physical 1 1 1 Affinity Capture-MS
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Negative Genetic
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 1 1 1 Synthetic Lethality
ALR1 YOL130W Plasma membrane Mg(2+) transporter genetic 1 1 1 Synthetic Lethality
ASM4 YDL088C FG-nucleoporin component of central core of nuclear pore complex (NPC) genetic 1 1 1 Positive Genetic
ATG27 YJL178C Type I membrane protein involved in autophagy and the Cvt pathway genetic 1 1 1 Negative Genetic
BMT2 YBR141C Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase genetic 1 1 1 Negative Genetic
ASK1 YKL052C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
BOS1 YLR078C v-SNARE (vesicle specific SNAP receptor) genetic 1 1 1 Synthetic Lethality
APC11 YDL008W Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Synthetic Lethality
APC4 YDR118W Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Synthetic Lethality
CDC21 YOR074C Thymidylate synthase genetic 1 1 1 Synthetic Lethality
BRF1 YGR246C TFIIIB B-related factor physical 1 1 1 Affinity Capture-MS
CDC31 YOR257W Calcium-binding component of the spindle pole body (SPB) half-bridge genetic 1 1 1 Synthetic Lethality
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 1 1 1 Negative Genetic
BRN1 YBL097W Subunit of the condensin complex genetic 1 1 1 Synthetic Lethality
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 1 1 1 Positive Genetic
BNI5 YNL166C Linker protein responsible for recruitment of myosin to the bud neck genetic 1 1 1 Negative Genetic
CBF2 YGR140W Essential kinetochore protein genetic 1 1 1 Synthetic Lethality
BET1 YIL004C Type II membrane protein required for vesicular transport genetic 1 1 1 Negative Genetic
CCZ1 YBR131W Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
BBP1 YPL255W Protein required for the spindle pole body (SPB) duplication genetic 1 1 1 Synthetic Lethality
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity genetic 1 1 1 Synthetic Lethality
ARG80 YMR042W Transcription factor involved in regulating arginine-responsive genes genetic 1 1 1 Negative Genetic
CAF16 YFL028C Part of evolutionarily-conserved CCR4-NOT regulatory complex genetic 1 1 1 Negative Genetic
CDC19 YAL038W Pyruvate kinase physical 1 1 1 Protein-RNA
BAT2 YJR148W Cytosolic branched-chain amino acid (BCAA) aminotransferase physical 1 1 1 Affinity Capture-MS
ADY4 YLR227C Structural component of the meiotic outer plaque genetic 1 1 1 Positive Genetic
ASH1 YKL185W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
AUR1 YKL004W Phosphatidylinositol:ceramide phosphoinositol transferase genetic 1 1 1 Negative Genetic
BET4 YJL031C Alpha subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
ATM1 YMR301C Mitochondrial inner membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Negative Genetic
AIM44 YPL158C Regulator of Cdc42p and Rho1p genetic 1 1 1 Positive Genetic
CCC1 YLR220W Vacuolar Fe2+/Mn2+ transporter genetic 1 1 1 Negative Genetic
BSC6 YOL137W Protein of unknown function with 8 putative transmembrane segments genetic 1 1 1 Positive Genetic
ANT1 YPR128C Peroxisomal adenine nucleotide transporter genetic 1 1 1 Positive Genetic
AEP3 YPL005W Peripheral mitochondrial inner membrane protein genetic 1 1 1 Negative Genetic
ACP1 YKL192C Mitochondrial matrix acyl carrier protein genetic 1 1 1 Synthetic Lethality
BAR1 YIL015W Aspartyl protease secreted to periplasmic space of mating type a cell genetic 1 1 1 Negative Genetic
BYE1 YKL005C Negative regulator of transcription elongation genetic 1 1 1 Negative Genetic
ARO2 YGL148W Bifunctional chorismate synthase and flavin reductase genetic 1 1 1 Positive Genetic
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
CAB1 YDR531W Pantothenate kinase, ATP:D-pantothenate 4'-phosphotransferase genetic 1 1 1 Negative Genetic
CDC50 YCR094W Endosomal protein that interacts with phospholipid flippase Drs2p genetic 1 1 1 Positive Genetic
ASI2 YNL159C Subunit of the inner nuclear membrane Asi ubiquitin ligase complex genetic 1 1 1 Negative Genetic
BRR6 YGL247W Essential nuclear envelope integral membrane protein genetic 1 1 1 Negative Genetic
AGC1 YPR021C Mitochondrial amino acid transporter genetic 1 1 1 Negative Genetic
CDC1 YDR182W Putative mannose-ethanolamine phosphate phosphodiesterase genetic 1 1 1 Negative Genetic
AIM19 YIL087C Protein of unknown function genetic 1 1 1 Negative Genetic
AIM33 YML087C Protein of unknown function, highly conserved across species genetic 1 1 1 Positive Genetic
CBT1 YKL208W Protein involved in 5' RNA end processing genetic 1 1 1 Negative Genetic
ADF1 YCL058W-A Transcriptional repressor encoded by the FYV5 antisense strand genetic 1 1 1 Positive Genetic