Standard name Systematic name Name description Description
UPS2 YLR168C Mitochondrial intermembrane space protein Mitochondrial intermembrane space protein; involved in phospholipid metabolism; forms complex with Mdm35p that transfers phosphatidylserine from outer membrane to inner membrane for phosphatidylethanolamine synthesis; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI; UPS2 has a paralog, UPS3, that arose from the whole genome duplication
Visualize the interactome of UPS2
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Mito 0.890 0.906 0.776
Nuc Periphery 0.072 NaN NaN
Vac/Vac Memb 0.190 0.195 0.165
Cell Periphery NaN NaN 0.071
Endosome NaN NaN 0.059
Golgi NaN NaN 0.235

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
UPS2 5 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
UPS1 YLR193C Phosphatidic acid transfer protein genetic 13 4 8 Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue
MDM31 YHR194W Mitochondrial protein that may have a role in phospholipid metabolism genetic 7 4 5 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Dosage Rescue, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement
PHB1 YGR132C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 7 3 5 Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality
MDM35 YKL053C-A Mitochondrial intermembrane space protein physical 5 3 4 Affinity Capture-Western, Affinity Capture-Western, Co-fractionation, Reconstituted Complex, Affinity Capture-Western
CRD1 YDL142C Cardiolipin synthase genetic 5 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality
UPS3 YDR185C Mitochondrial protein of unknown function genetic 5 5 3 Dosage Rescue, Phenotypic Suppression, Synthetic Rescue, Phenotypic Enhancement, Synthetic Growth Defect
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 5 3 3 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement
FMP30 YPL103C Protein with a role in maintaining mitochondrial morphology genetic 5 2 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Enhancement
CDC73 YLR418C Component of the Paf1p complex genetic 3 3 3 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PEX29 YDR479C ER-resident protein involved in peroxisomal biogenesis genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MDM34 YGL219C Mitochondrial component of the ERMES complex genetic 2 2 2 Positive Genetic, Synthetic Rescue
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 2 1 2 DNA to cDNA expression microarray evidence, DNA to cDNA expression microarray evidence
LSM1 YJL124C Lsm (Like Sm) protein genetic 2 1 2 Negative Genetic, Negative Genetic
IDH2 YOR136W Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase genetic 2 1 2 Negative Genetic, Negative Genetic
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway genetic 2 1 2 Positive Genetic, Positive Genetic
UBC7 YMR022W Ubiquitin conjugating enzyme genetic 2 1 2 Negative Genetic, Negative Genetic
UBC6 YER100W Ubiquitin-conjugating enzyme involved in ERAD genetic 2 1 2 Negative Genetic, Negative Genetic
APL4 YPR029C Gamma-adaptin genetic 2 1 2 Negative Genetic, Negative Genetic
TOS6 YNL300W Glycosylphosphatidylinositol-dependent cell wall protein genetic 2 1 2 Negative Genetic, Negative Genetic
CBP4 YGR174C Mitochondrial protein required for assembly of cytochrome bc1 complex genetic 2 1 2 Negative Genetic, Negative Genetic
SAM4 YPL273W S-adenosylmethionine-homocysteine methyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
CHO1 YER026C Phosphatidylserine synthase genetic 2 2 1 Dosage Rescue, Phenotypic Suppression
MIC60 YKR016W Component of the MICOS complex genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation- exonuclease evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MSN2 YMR037C Stress-responsive transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CYC8 YBR112C General transcriptional co-repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ADA2 YDR448W Transcription coactivator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
NCB2 YDR397C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
OPI1 YHL020C Transcriptional regulator of a variety of genes regulation 1 1 1 DNA to cDNA expression microarray evidence
NHP6A YPR052C High-mobility group (HMG) protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
LEO1 YOR123C Component of the Paf1 complex genetic 1 1 1 Negative Genetic
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) genetic 1 1 1 Positive Genetic
SAP190 YKR028W Protein that forms a complex with the Sit4p protein phosphatase genetic 1 1 1 Negative Genetic
SSD1 YDR293C Translational repressor genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
ELP2 YGR200C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
MDM10 YAL010C Subunit of both the ERMES and the SAM complex genetic 1 1 1 Synthetic Rescue
MRPL10 YNL284C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
PIM1 YBL022C ATP-dependent Lon protease genetic 1 1 1 Negative Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer genetic 1 1 1 Negative Genetic
ABF2 YMR072W Mitochondrial DNA-binding protein genetic 1 1 1 Negative Genetic
HRK1 YOR267C Protein kinase genetic 1 1 1 Positive Genetic
BSP1 YPR171W Adapter that links synaptojanins to the cortical actin cytoskeleton genetic 1 1 1 Negative Genetic
SLY1 YDR189W Hydrophilic protein involved in ER/Golgi vesicle trafficking genetic 1 1 1 Negative Genetic
SMD2 YLR275W Core Sm protein Sm D2 genetic 1 1 1 Negative Genetic
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
PSK1 YAL017W PAS domain-containing serine/threonine protein kinase genetic 1 1 1 Negative Genetic
SKN1 YGR143W Protein involved in sphingolipid biosynthesis genetic 1 1 1 Negative Genetic
ALT2 YDR111C Catalytically inactive alanine transaminase genetic 1 1 1 Negative Genetic
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 1 1 1 Negative Genetic
DTD1 YDL219W D-Tyr-tRNA(Tyr) deacylase genetic 1 1 1 Negative Genetic
CYM1 YDR430C Lysine-specific metalloprotease of the pitrilysin family genetic 1 1 1 Negative Genetic
AIM17 YHL021C Protein of unknown function genetic 1 1 1 Negative Genetic
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
APP1 YNL094W Phosphatidate phosphatase, converts phosphatidate to diacylglycerol genetic 1 1 1 Negative Genetic
HXT6 YDR343C High-affinity glucose transporter genetic 1 1 1 Negative Genetic
PMA2 YPL036W Plasma membrane H+-ATPase genetic 1 1 1 Positive Genetic
CHK1 YBR274W Serine/threonine kinase and DNA damage checkpoint effector genetic 1 1 1 Negative Genetic
SSK2 YNR031C MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway genetic 1 1 1 Positive Genetic
ISU1 YPL135W Conserved protein of the mitochondrial matrix genetic 1 1 1 Negative Genetic
BUD7 YOR299W Member of the ChAPs family (Chs5p-Arf1p-binding proteins) genetic 1 1 1 Negative Genetic
PTP2 YOR208W Phosphotyrosine-specific phosphatase genetic 1 1 1 Negative Genetic
HMG2 YLR450W HMG-CoA reductase genetic 1 1 1 Negative Genetic
MDJ1 YFL016C Co-chaperone that stimulates HSP70 protein Ssc1p ATPase activity genetic 1 1 1 Negative Genetic
GEP4 YHR100C Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase) genetic 1 1 1 Negative Genetic
GTR1 YML121W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 1 1 1 Negative Genetic
HSP10 YOR020C Mitochondrial matrix co-chaperonin genetic 1 1 1 Negative Genetic
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 1 1 1 Negative Genetic
SIW14 YNL032W Inositol phosphatase involved in inositol pyrophosphate metabolism genetic 1 1 1 Negative Genetic
CEP3 YMR168C Essential kinetochore protein genetic 1 1 1 Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Positive Genetic
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
CSE4 YKL049C Centromeric histone H3-like protein genetic 1 1 1 Positive Genetic
MDM12 YOL009C Mitochondrial outer membrane protein, ERMES complex subunit genetic 1 1 1 Synthetic Rescue
MTH1 YDR277C Negative regulator of the glucose-sensing signal transduction pathway genetic 1 1 1 Negative Genetic
TIM18 YOR297C Component of the mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
TOM20 YGR082W Component of the TOM (translocase of outer membrane) complex physical 1 1 1 Affinity Capture-Western
TOM22 YNL131W Component of the TOM (Translocase of Outer Membrane) complex physical 1 1 1 Affinity Capture-Western
RSM19 YNR037C Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Negative Genetic
PBP1 YGR178C Component of glucose deprivation induced stress granules genetic 1 1 1 Positive Genetic
PAM16 YJL104W Subunit of the import motor (PAM complex) genetic 1 1 1 Negative Genetic
RNR4 YGR180C Ribonucleotide-diphosphate reductase (RNR) small subunit genetic 1 1 1 Negative Genetic
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p genetic 1 1 1 Negative Genetic
ILV6 YCL009C Regulatory subunit of acetolactate synthase genetic 1 1 1 Negative Genetic
PLP1 YDR183W Protein that interacts with CCT (chaperonin containing TCP-1) complex genetic 1 1 1 Negative Genetic
CAT2 YML042W Carnitine acetyl-CoA transferase genetic 1 1 1 Negative Genetic
PSG1 YKL077W Protein that promotes the transport and maturation of Pma1 with Exp1 genetic 1 1 1 Negative Genetic
PAM17 YKR065C Constituent of the TIM23 complex genetic 1 1 1 Synthetic Growth Defect
ALG3 YBL082C Dolichol-P-Man dependent alpha(1-3) mannosyltransferase genetic 1 1 1 Negative Genetic
NFS1 YCL017C Cysteine desulfurase involved in iron-sulfur cluster biogenesis genetic 1 1 1 Negative Genetic
KXD1 YGL079W Subunit of the BLOC-1 complex involved in endosomal maturation genetic 1 1 1 Negative Genetic
PSD2 YGR170W Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes genetic 1 1 1 Synthetic Lethality
CWP2 YKL096W-A Covalently linked cell wall mannoprotein genetic 1 1 1 Negative Genetic
PSP2 YML017W Asn rich cytoplasmic protein that contains RGG motifs genetic 1 1 1 Negative Genetic
UGO1 YDR470C Outer membrane component of the mitochondrial fusion machinery genetic 1 1 1 Negative Genetic
ADE12 YNL220W Adenylosuccinate synthase genetic 1 1 1 Negative Genetic
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-RNA
GLN4 YOR168W Glutamine tRNA synthetase genetic 1 1 1 Positive Genetic
TYS1 YGR185C Cytoplasmic tyrosyl-tRNA synthetase genetic 1 1 1 Negative Genetic
LAP3 YNL239W Cysteine aminopeptidase with homocysteine-thiolactonase activity genetic 1 1 1 Negative Genetic
ACL4 YDR161W Specific assembly chaperone for ribosomal protein Rpl4a/Rpl4b genetic 1 1 1 Negative Genetic
ULP1 YPL020C Protease that specifically cleaves Smt3p protein conjugates genetic 1 1 1 Negative Genetic
RPS27B YHR021C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
MRX18 YBR056W Putative glycoside hydrolase of the mitochondrial intermembrane space genetic 1 1 1 Negative Genetic
AIM6 YDL237W Protein of unknown function genetic 1 1 1 Negative Genetic
PRY1 YJL079C Lipid binding protein genetic 1 1 1 Negative Genetic
ERP4 YOR016C Member of the p24 family involved in ER to Golgi transport genetic 1 1 1 Positive Genetic
HNT2 YDR305C Dinucleoside triphosphate hydrolase genetic 1 1 1 Positive Genetic
TMH11 YJR085C Mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
DCW1 YKL046C Putative mannosidase genetic 1 1 1 Positive Genetic
EMI1 YDR512C Non-essential protein of unknown function genetic 1 1 1 Negative Genetic
TRS65 YGR166W Component of transport protein particle (TRAPP) complex II genetic 1 1 1 Negative Genetic
MDM35 YKL053C-A Mitochondrial intermembrane space protein genetic 1 1 1 Dosage Lethality
MIC10 YCL057C-A Conserved component of the MICOS complex genetic 1 1 1 Phenotypic Suppression
EMC3 YKL207W Member of conserved ER transmembrane complex genetic 1 1 1 Negative Genetic
CQD2 YLR253W Mitochondrial protein involved in lipid homeostasis genetic 1 1 1 Synthetic Rescue
ATG22 YCL038C Vacuolar integral membrane protein required for efflux of amino acids genetic 1 1 1 Negative Genetic
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Synthetic Rescue
PIF1 YML061C DNA helicase, potent G-quadruplex DNA binder/unwinder genetic 1 1 1 Negative Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex physical 1 1 1 Affinity Capture-MS
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 1 1 1 Negative Genetic
VPS52 YDR484W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
URE2 YNL229C Nitrogen catabolite repression transcriptional regulator genetic 1 1 1 Positive Genetic
YBR238C YBR238C Mitochondrial membrane protein genetic 1 1 1 Positive Genetic
YJR120W YJR120W Protein of unknown function genetic 1 1 1 Positive Genetic
YOR008C-A YOR008C-A Putative protein of unknown function genetic 1 1 1 Positive Genetic
VTI1 YMR197C Protein involved in cis-Golgi membrane traffic genetic 1 1 1 Negative Genetic
YGR283C YGR283C Putative methyltransferase genetic 1 1 1 Negative Genetic
YHR213W YHR213W Pseudogenic fragment with similarity to flocculins genetic 1 1 1 Negative Genetic
URC2 YDR520C Putative Zn(II)2Cys6 motif containing transcription factor genetic 1 1 1 Negative Genetic
YFL051C YFL051C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YKR104W YKR104W Putative transporter of the MRP subfamily genetic 1 1 1 Negative Genetic
YLR446W YLR446W Putative hexokinase genetic 1 1 1 Negative Genetic
YHM2 YMR241W Citrate and oxoglutarate carrier protein genetic 1 1 1 Negative Genetic
ZRG17 YNR039C Endoplasmic reticulum zinc transporter genetic 1 1 1 Negative Genetic
YOL013W-A YOL013W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YML054C-A YML054C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YMR295C YMR295C Protein of unknown function that associates with ribosomes genetic 1 1 1 Negative Genetic
MGR2 YPL098C Subunit of the TIM23 translocase complex genetic 1 1 1 Negative Genetic
RTC2 YBR147W Putative vacuolar membrane transporter for cationic amino acids genetic 1 1 1 Negative Genetic
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER genetic 1 1 1 Negative Genetic
QRI7 YDL104C Protein involved in threonylcarbamoyl adenosine biosynthesis genetic 1 1 1 Negative Genetic
RML2 YEL050C Mitochondrial ribosomal protein of the large subunit (L2) genetic 1 1 1 Positive Genetic
RSM26 YJR101W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Positive Genetic
SPF1 YEL031W P-type ATPase, ion transporter of the ER membrane genetic 1 1 1 Negative Genetic
KCH1 YJR054W Potassium transporter that mediates K+ influx genetic 1 1 1 Negative Genetic
SSP2 YOR242C Sporulation specific protein that localizes to the spore wall genetic 1 1 1 Positive Genetic
STP4 YDL048C Protein containing a Kruppel-type zinc-finger domain genetic 1 1 1 Negative Genetic
SSH4 YKL124W Specificity factor required for Rsp5p-dependent ubiquitination genetic 1 1 1 Negative Genetic
TRM44 YPL030W tRNA(Ser) Um(44) 2'-O-methyltransferase genetic 1 1 1 Negative Genetic
OAF3 YKR064W Putative transcriptional repressor with Zn(2)-Cys(6) finger genetic 1 1 1 Negative Genetic
MMO1 YKL044W Protein of unknown function genetic 1 1 1 Negative Genetic