Standard name Systematic name Name description Description
UBC6 YER100W Ubiquitin-conjugating enzyme involved in ERAD Ubiquitin-conjugating enzyme involved in ERAD; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway; ER-associated protein degradation is also known as ERAD
Visualize the interactome of UBC6
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm NaN 0.829 0.782
ER NaN 0.137 0.099
Mito NaN NaN 0.198

GFP localization & abundance

GFP localization GFP abundance
ER 1900

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
UBC6 11 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
UBC7 YMR022W Ubiquitin conjugating enzyme genetic 11 2 10 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement
SSM4 YIL030C Membrane-embedded ubiquitin-protein ligase and retrotranslocase physical 5 4 4 Affinity Capture-Western, PCA, Biochemical Activity, Reconstituted Complex, Biochemical Activity
UBA1 YKL210W Ubiquitin activating enzyme (E1) physical 4 3 3 Affinity Capture-MS, Biochemical Activity, Reconstituted Complex, Biochemical Activity
RSP5 YER125W NEDD4 family E3 ubiquitin ligase physical 3 3 3 Protein-peptide, Affinity Capture-MS, PCA
UBC6 YER100W Ubiquitin-conjugating enzyme involved in ERAD physical 3 1 3 Biochemical Activity, Biochemical Activity, Biochemical Activity
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 3 1 3 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ASI3 YNL008C Subunit of the inner nuclear membrane Asi ubiquitin ligase complex physical 3 2 1 PCA, PCA, Reconstituted Complex
ASI1 YMR119W Subunit of the inner nuclear membrane Asi ubiquitin ligase complex physical 3 2 1 PCA, PCA, Reconstituted Complex
SEC62 YPL094C Essential subunit of Sec63 complex genetic 2 2 2 Negative Genetic, Synthetic Rescue
UBC7 YMR022W Ubiquitin conjugating enzyme physical 2 2 2 Two-hybrid, Biochemical Activity
SEC61 YLR378C Conserved ER protein translocation channel genetic 2 2 2 Phenotypic Suppression, Synthetic Rescue
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase genetic 2 1 2 Negative Genetic, Negative Genetic
AEP2 YMR282C Mitochondrial protein genetic 2 1 2 Negative Genetic, Negative Genetic
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 2 1 2 Negative Genetic, Negative Genetic
MSH4 YFL003C Protein involved in meiotic recombination genetic 2 1 2 Negative Genetic, Negative Genetic
RHO2 YNL090W Non-essential small GTPase of the Rho/Rac family of Ras-like proteins genetic 2 1 2 Positive Genetic, Positive Genetic
QCR2 YPR191W Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) genetic 2 1 2 Negative Genetic, Negative Genetic
OMS1 YDR316W Protein integral to the mitochondrial membrane genetic 2 1 2 Positive Genetic, Positive Genetic
YCL002C YCL002C Putative protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
YFL012W YFL012W Putative protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
UPS2 YLR168C Mitochondrial intermembrane space protein genetic 2 1 2 Negative Genetic, Negative Genetic
VPS17 YOR132W Subunit of the membrane-associated retromer complex genetic 2 1 2 Negative Genetic, Negative Genetic
PCL8 YPL219W Cyclin genetic 2 1 2 Negative Genetic, Negative Genetic
PEF1 YGR058W Penta-EF-hand protein genetic 2 1 2 Negative Genetic, Negative Genetic
CHL1 YPL008W Probable DNA helicase genetic 2 1 2 Negative Genetic, Negative Genetic
PHO80 YOL001W Cyclin genetic 2 1 2 Negative Genetic, Negative Genetic
REC104 YHR157W Protein involved in early stages of meiotic recombination genetic 2 1 2 Negative Genetic, Negative Genetic
ATP18 YML081C-A Subunit of the mitochondrial F1F0 ATP synthase genetic 2 1 2 Negative Genetic, Negative Genetic
ATG32 YIL146C Mitochondrial outer membrane protein required to initiate mitophagy genetic 2 1 2 Negative Genetic, Negative Genetic
ETR1 YBR026C 2-enoyl thioester reductase genetic 2 1 2 Negative Genetic, Negative Genetic
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 2 1 2 Negative Genetic, Negative Genetic
COX10 YPL172C Heme A:farnesyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
MDM38 YOL027C Membrane-associated mitochondrial ribosome receptor genetic 2 1 2 Negative Genetic, Negative Genetic
STE24 YJR117W Highly conserved zinc metalloprotease genetic 2 1 2 Negative Genetic, Negative Genetic
MDM35 YKL053C-A Mitochondrial intermembrane space protein genetic 2 1 2 Negative Genetic, Negative Genetic
MCT1 YOR221C Predicted malonyl-CoA:ACP transferase genetic 2 1 2 Negative Genetic, Negative Genetic
STE14 YDR410C Farnesyl cysteine-carboxyl methyltransferase physical 2 1 2 PCA, PCA
OAR1 YKL055C Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase genetic 2 1 2 Negative Genetic, Negative Genetic
CBF2 YGR140W Essential kinetochore protein genetic 2 2 1 Dosage Rescue, Synthetic Rescue
SHR3 YDL212W Endoplasmic reticulum packaging chaperone genetic 2 2 1 Phenotypic Enhancement, Phenotypic Suppression
APL5 YPL195W Delta adaptin-like subunit of the clathrin associated protein complex genetic 2 1 1 Positive Genetic, Positive Genetic
PHO86 YJL117W Endoplasmic reticulum (ER) resident protein genetic 2 1 1 Negative Genetic, Negative Genetic
SGM1 YJR134C Protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
SSH1 YBR283C Subunit of the Ssh1 translocon complex genetic 2 1 1 Negative Genetic, Negative Genetic
ANY1 YMR010W Protein involved in phospholipid flippase function genetic 2 1 1 Positive Genetic, Positive Genetic
TED1 YIL039W GPI-glycan remodelase genetic 2 1 1 Positive Genetic, Positive Genetic
EMA19 YLR050C Integral ER membrane protein involved in protein sorting genetic 2 1 1 Positive Genetic, Positive Genetic
LCB4 YOR171C Sphingoid long-chain base kinase genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CAD1 YDR423C AP-1-like basic leucine zipper (bZIP) transcriptional activator regulation 1 1 1 DNA to cDNA expression microarray evidence
SSM4 YIL030C Membrane-embedded ubiquitin-protein ligase and retrotranslocase regulation 1 1 1 green fluorescent protein reporter gene assay evidence
CLF1 YLR117C Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 1 1 1 Affinity Capture-MS
NIP7 YPL211W Nucleolar protein required for 60S ribosome subunit biogenesis genetic 1 1 1 Negative Genetic
RRP1 YDR087C Essential evolutionarily conserved nucleolar protein genetic 1 1 1 Negative Genetic
RAX2 YLR084C Protein required for the maintenance of bud site selection genetic 1 1 1 Negative Genetic
PRP19 YLL036C Splicing factor associated with the spliceosome physical 1 1 1 PCA
POL5 YEL055C Protein involved in 60S assembly and pre-40S AFs recycling physical 1 1 1 Affinity Capture-MS
MES1 YGR264C Methionyl-tRNA synthetase genetic 1 1 1 Negative Genetic
CDC48 YDL126C AAA ATPase with protein-unfoldase activity physical 1 1 1 Reconstituted Complex
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 1 1 1 Positive Genetic
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
SSD1 YDR293C Translational repressor genetic 1 1 1 Negative Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily physical 1 1 1 PCA
BEM1 YBR200W Protein containing SH3-domains genetic 1 1 1 Negative Genetic
CLP1 YOR250C Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Positive Genetic
GCN1 YGL195W Positive regulator of the Gcn2p kinase activity physical 1 1 1 Affinity Capture-MS
CCT4 YDL143W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Positive Genetic
LCB1 YMR296C Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
MRPL1 YDR116C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control genetic 1 1 1 Synthetic Growth Defect
ATG3 YNR007C E2-like enzyme genetic 1 1 1 Negative Genetic
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Two-hybrid
LEA1 YPL213W Component of U2 snRNP complex genetic 1 1 1 Negative Genetic
NAB3 YPL190C RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) genetic 1 1 1 Negative Genetic
MIR1 YJR077C Mitochondrial phosphate carrier physical 1 1 1 Two-hybrid
NUT2 YPR168W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
NUM1 YDR150W Protein required for nuclear migration genetic 1 1 1 Negative Genetic
SEC7 YDR170C Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors physical 1 1 1 Affinity Capture-MS
SLA1 YBL007C Cytoskeletal protein binding protein genetic 1 1 1 Negative Genetic
SLY1 YDR189W Hydrophilic protein involved in ER/Golgi vesicle trafficking genetic 1 1 1 Phenotypic Suppression
SEC65 YML105C Subunit of the signal recognition particle (SRP) genetic 1 1 1 Negative Genetic
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l genetic 1 1 1 Positive Genetic
SPC97 YHR172W Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex genetic 1 1 1 Negative Genetic
FLC2 YAL053W Putative calcium channel involved in calcium release under hypotonic physical 1 1 1 PCA
GET3 YDL100C Guanine nucleotide exchange factor for Gpa1p physical 1 1 1 Reconstituted Complex
ATP4 YPL078C Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase physical 1 1 1 Affinity Capture-MS
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 1 1 1 Negative Genetic
SPS1 YDR523C STE20-family GCKIII protein kinase physical 1 1 1 Reconstituted Complex
MET30 YIL046W F-box protein containing five copies of the WD40 motif genetic 1 1 1 Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 1 1 1 Phenotypic Enhancement
TMA19 YKL056C Protein that associates with ribosomes physical 1 1 1 Affinity Capture-MS
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 1 1 1 Negative Genetic
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) genetic 1 1 1 Negative Genetic
ECM33 YBR078W GPI-anchored protein involved in efficient glucose uptake genetic 1 1 1 Positive Genetic
YPT1 YFL038C Rab family GTPase physical 1 1 1 Affinity Capture-MS
UTP20 YBL004W Component of the small-subunit (SSU) processome physical 1 1 1 Affinity Capture-MS
YPL229W YPL229W Putative protein of unknown function physical 1 1 1 Two-hybrid
YBR184W YBR184W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YIH1 YCR059C Negative regulator of eIF2 kinase Gcn2p genetic 1 1 1 Negative Genetic
YOS9 YDR057W ER quality-control lectin genetic 1 1 1 Negative Genetic
YPR089W YPR089W Protein of unknown function genetic 1 1 1 Negative Genetic
UFE1 YOR075W t-SNARE protein required for retrograde vesicular traffic genetic 1 1 1 Phenotypic Suppression
WWM1 YFL010C WW domain containing protein of unknown function genetic 1 1 1 Negative Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
YJR084W YJR084W Protein that forms a complex with Thp3p genetic 1 1 1 Negative Genetic
VPS13 YLL040C Lipid transport protein involved in prospore membrane morphogenesis genetic 1 1 1 Negative Genetic
UBX4 YMR067C UBX domain-containing protein that interacts with Cdc48p genetic 1 1 1 Negative Genetic
YNL140C YNL140C Protein of unknown function genetic 1 1 1 Negative Genetic
LOS1 YKL205W Nuclear pore protein physical 1 1 1 Affinity Capture-MS
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Negative Genetic
CIN5 YOR028C Basic leucine zipper (bZIP) transcription factor of the yAP-1 family genetic 1 1 1 Negative Genetic
ERG11 YHR007C Lanosterol 14-alpha-demethylase genetic 1 1 1 Negative Genetic
UBA4 YHR111W E1-like protein that activates Urm1p before urmylation physical 1 1 1 Reconstituted Complex
MCM10 YIL150C Essential chromatin-associated protein genetic 1 1 1 Negative Genetic
GIP1 YBR045C Meiosis-specific regulatory subunit of the Glc7p protein phosphatase genetic 1 1 1 Negative Genetic
NDC1 YML031W Subunit of the transmembrane ring of the nuclear pore complex (NPC) genetic 1 1 1 Synthetic Rescue
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Negative Genetic
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 1 1 1 Negative Genetic
IPL1 YPL209C Aurora kinase of chromosomal passenger complex genetic 1 1 1 Negative Genetic
PEX10 YDR265W Peroxisomal membrane E3 ubiquitin ligase physical 1 1 1 PCA
PEX2 YJL210W RING-finger peroxin and E3 ubiquitin ligase physical 1 1 1 PCA
PEX5 YDR244W Peroxisomal membrane signal receptor for peroxisomal matrix proteins genetic 1 1 1 Positive Genetic
CDC21 YOR074C Thymidylate synthase genetic 1 1 1 Negative Genetic
HPC2 YBR215W Subunit of the HIR complex genetic 1 1 1 Negative Genetic
PRP2 YNR011C RNA-dependent DExD/H-box ATPase genetic 1 1 1 Negative Genetic
SSC1 YJR045C Hsp70 family ATPase genetic 1 1 1 Negative Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 1 1 1 Negative Genetic
EPS1 YIL005W ER protein with chaperone and co-chaperone activity genetic 1 1 1 Synthetic Growth Defect
RPA14 YDR156W RNA polymerase I subunit A14 genetic 1 1 1 Positive Genetic
SEC61 YLR378C Conserved ER protein translocation channel physical 1 1 1 Affinity Capture-MS
MPS2 YGL075C Essential membrane protein localized at nuclear envelope and SPBs genetic 1 1 1 Synthetic Rescue
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 1 1 1 Negative Genetic
SMC4 YLR086W Subunit of the condensin complex genetic 1 1 1 Negative Genetic
HSF1 YGL073W Trimeric heat shock transcription factor genetic 1 1 1 Negative Genetic
RRN7 YJL025W Component of the core factor (CF) rDNA transcription factor complex genetic 1 1 1 Positive Genetic
TUL1 YKL034W Subunit of the DSC ubiquitin ligase complex physical 1 1 1 Two-hybrid
ARG80 YMR042W Transcription factor involved in regulating arginine-responsive genes genetic 1 1 1 Negative Genetic
MID2 YLR332W O-glycosylated plasma membrane protein genetic 1 1 1 Negative Genetic
SNM1 YDR478W Ribonuclease MRP complex subunit genetic 1 1 1 Negative Genetic
HRD1 YOL013C Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) physical 1 1 1 Reconstituted Complex
HRD1 YOL013C Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) genetic 1 1 1 Phenotypic Enhancement
ERG5 YMR015C C-22 sterol desaturase genetic 1 1 1 Negative Genetic
CIT1 YNR001C Mitochondrial citrate synthase genetic 1 1 1 Negative Genetic
HUL4 YJR036C Protein with similarity to hect domain E3 ubiquitin-protein ligases physical 1 1 1 PCA
TFB3 YDR460W Subunit of TFIIH and nucleotide excision repair factor 3 complexes physical 1 1 1 PCA
AIM22 YJL046W Lipoate-protein ligase genetic 1 1 1 Negative Genetic
PDC2 YDR081C Transcription factor for thiamine-regulated genes genetic 1 1 1 Positive Genetic
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
SDD2 YMR074C Protein with homology to human PDCD5 genetic 1 1 1 Negative Genetic
NUP192 YJL039C Essential subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Positive Genetic
SCT1 YBL011W Glycerol 3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase genetic 1 1 1 Negative Genetic
EOS1 YNL080C Protein involved in N-glycosylation genetic 1 1 1 Positive Genetic
CYT1 YOR065W Cytochrome c1 genetic 1 1 1 Negative Genetic
SSM4 YIL030C Membrane-embedded ubiquitin-protein ligase and retrotranslocase genetic 1 1 1 Synthetic Rescue
SAD1 YFR005C Conserved zinc-finger domain protein involved in pre-mRNA splicing genetic 1 1 1 Negative Genetic
MUP1 YGR055W High affinity methionine permease genetic 1 1 1 Negative Genetic
NRE1 YIR035C Putative cytoplasmic short-chain dehydrogenase/reductase genetic 1 1 1 Negative Genetic
DIT1 YDR403W Sporulation-specific enzyme required for spore wall maturation genetic 1 1 1 Negative Genetic
ATO2 YNR002C Putative transmembrane protein involved in export of ammonia genetic 1 1 1 Negative Genetic
QRI1 YDL103C UDP-N-acetylglucosamine pyrophosphorylase genetic 1 1 1 Positive Genetic
TDA5 YLR426W Putative protein of unknown function genetic 1 1 1 Negative Genetic
CMC1 YKL137W Copper-binding protein of the mitochondrial intermembrane space genetic 1 1 1 Positive Genetic
LIP2 YLR239C Lipoyl ligase genetic 1 1 1 Negative Genetic
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex genetic 1 1 1 Negative Genetic
FSH1 YHR049W Lysophospholipase genetic 1 1 1 Negative Genetic
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Negative Genetic
PDE2 YOR360C High-affinity cyclic AMP phosphodiesterase genetic 1 1 1 Negative Genetic
UBC5 YDR059C Ubiquitin-conjugating enzyme genetic 1 1 1 Phenotypic Enhancement
TAD3 YLR316C Subunit of tRNA-specific adenosine-34 deaminase genetic 1 1 1 Negative Genetic