Standard name Systematic name Name description Description
CIT1 YNR001C Mitochondrial citrate synthase Mitochondrial citrate synthase; catalyzes condensation of acetyl coenzyme A and oxaloacetate to form citrate, which is the first and rate-limiting step of the TCA cycle; transcription subject to glucose repression; CIT1 has a paralog, CIT2, that arose from the whole genome duplication
Visualize the interactome of CIT1
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1/S 46

CYCLoPs localization & abundance

WT1 WT2 WT3
Mito 0.960 0.924 0.963
Nucleolus 0.099 NaN NaN
Vac/Vac Memb 0.073 0.185 NaN
Nuc Periphery NaN 0.060 NaN
Peroxisome NaN NaN 0.136

GFP localization & abundance

GFP localization GFP abundance
mitochondrion no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
CIT1 4 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0300 (citrate synthase)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
CIT2 YCR005C Citrate synthase, peroxisomal isozyme involved in glyoxylate cycle genetic 13 4 11 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Enhancement
IDH2 YOR136W Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase genetic 7 4 4 Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Positive Genetic, Positive Genetic, Positive Genetic
CIT3 YPR001W Dual specificity mitochondrial citrate and methylcitrate synthase genetic 5 4 4 Synthetic Lethality, Synthetic Growth Defect, Dosage Rescue, Synthetic Growth Defect, Phenotypic Enhancement
HTD2 YHR067W Mitochondrial 3-hydroxyacyl-thioester dehydratase genetic 5 1 4 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 4 3 4 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
RTG2 YGL252C Sensor of mitochondrial dysfunction genetic 4 2 4 Phenotypic Suppression, Negative Genetic, Negative Genetic, Negative Genetic
ACH1 YBL015W Protein with CoA transferase activity genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ACO1 YLR304C Aconitase genetic 4 3 2 Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression
YHM2 YMR241W Citrate and oxoglutarate carrier protein genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ETR1 YBR026C 2-enoyl thioester reductase genetic 3 1 3 Positive Genetic, Positive Genetic, Positive Genetic
MDH1 YKL085W Mitochondrial malate dehydrogenase physical 3 3 2 Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 3 2 2 Phenotypic Suppression, Negative Genetic, Negative Genetic
LPD1 YFL018C Dihydrolipoamide dehydrogenase genetic 3 2 2 Positive Genetic, Synthetic Rescue, Synthetic Rescue
LIP2 YLR239C Lipoyl ligase genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
OAR1 YKL055C Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
IDH1 YNL037C Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase genetic 3 3 1 Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement
FKH2 YNL068C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
TIM23 YNR017W Essential component of the TIM23 complex physical 2 2 2 Co-fractionation, Affinity Capture-MS
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RAD4 YER162C Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 genetic 2 1 2 Negative Genetic, Negative Genetic
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex genetic 2 1 2 Positive Genetic, Positive Genetic
GCV3 YAL044C H subunit of the mitochondrial glycine decarboxylase complex genetic 2 1 1 Positive Genetic, Positive Genetic
HFA1 YMR207C Mitochondrial acetyl-coenzyme A carboxylase genetic 2 1 1 Positive Genetic, Positive Genetic
CTP1 YBR291C Mitochondrial inner membrane citrate transporter genetic 2 1 1 Negative Genetic, Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 2 1 1 Negative Genetic, Negative Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis regulation 1 1 1 DNA to cDNA expression microarray evidence
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis regulation 1 1 1 DNA to cDNA expression microarray evidence
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT7 YBR081C Subunit of the SAGA transcriptional regulatory complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BAS1 YKR099W Myb-related transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways regulation 1 1 1 DNA to cDNA expression microarray evidence
HAP2 YGL237C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex regulation 1 1 1 beta-galactosidase reporter gene assay evidence
PTC7 YHR076W Type 2C serine/threonine protein phosphatase (PP2C) regulation 1 1 1 enzymatic activity assay evidence
CDC42 YLR229C Small rho-like GTPase genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 1 1 1 Negative Genetic
BUD31 YCR063W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Negative Genetic
AVO1 YOL078W Component of the membrane-bound TORC2 complex genetic 1 1 1 Negative Genetic
AFG2 YLR397C ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex genetic 1 1 1 Negative Genetic
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-MS
ATG12 YBR217W Ubiquitin-like modifier involved in autophagy and the Cvt pathway genetic 1 1 1 Negative Genetic
ATP7 YKL016C Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase genetic 1 1 1 Negative Genetic
CCP1 YKR066C Mitochondrial cytochrome-c peroxidase physical 1 1 1 Co-fractionation
BET4 YJL031C Alpha subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-RNA
MIC60 YKR016W Component of the MICOS complex physical 1 1 1 Affinity Capture-MS
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
TFS1 YLR178C Inhibitor of carboxypeptidase Y (Prc1p), and Ras GAP (Ira2p) physical 1 1 1 Affinity Capture-MS
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 1 1 1 Affinity Capture-MS
SSA2 YLL024C HSP70 family ATP-binding protein physical 1 1 1 Affinity Capture-MS
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
COX4 YGL187C Subunit IV of cytochrome c oxidase physical 1 1 1 Affinity Capture-MS
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
RSP5 YER125W NEDD4 family E3 ubiquitin ligase physical 1 1 1 Affinity Capture-MS
SSC1 YJR045C Hsp70 family ATPase physical 1 1 1 Affinity Capture-MS
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex physical 1 1 1 Affinity Capture-MS
COX20 YDR231C Mitochondrial inner membrane protein physical 1 1 1 Affinity Capture-MS
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
TMA108 YIL137C Ribosome-associated, nascent chain binding factor physical 1 1 1 Affinity Capture-MS
RPL16A YIL133C Ribosomal 60S subunit protein L16A physical 1 1 1 Affinity Capture-MS
TMA46 YOR091W Protein of unknown function that associates with translating ribosomes physical 1 1 1 Affinity Capture-MS
COQ9 YLR201C Protein required for ubiquinone biosynthesis and respiratory growth physical 1 1 1 Affinity Capture-MS
COQ9 YLR201C Protein required for ubiquinone biosynthesis and respiratory growth genetic 1 1 1 Negative Genetic
SAM50 YNL026W Component of the Sorting and Assembly Machinery (SAM) complex physical 1 1 1 Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
CIT1 YNR001C Mitochondrial citrate synthase physical 1 1 1 Reconstituted Complex
MRPL1 YDR116C Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Proximity Label-MS
SEC61 YLR378C Conserved ER protein translocation channel physical 1 1 1 Affinity Capture-MS
RPS2 YGL123W Protein component of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPL25 YOL127W Ribosomal 60S subunit protein L25 physical 1 1 1 Affinity Capture-MS
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPO21 YDL140C RNA polymerase II largest subunit B220 physical 1 1 1 Affinity Capture-MS
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 1 1 1 Affinity Capture-MS
MCA1 YOR197W Ca2+-dependent cysteine protease genetic 1 1 1 Synthetic Rescue
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Growth Defect
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
SYM1 YLR251W Protein required for ethanol metabolism genetic 1 1 1 Synthetic Growth Defect
PHO87 YCR037C Low-affinity inorganic phosphate (Pi) transporter genetic 1 1 1 Positive Genetic
RIB2 YOL066C Bifunctional DRAP deaminase tRNA:pseudouridine synthase genetic 1 1 1 Negative Genetic
PDX3 YBR035C Pyridoxine (pyridoxamine) phosphate oxidase genetic 1 1 1 Negative Genetic
FCY21 YER060W Putative purine-cytosine permease genetic 1 1 1 Negative Genetic
ILV3 YJR016C Dihydroxyacid dehydratase genetic 1 1 1 Negative Genetic
ELO2 YCR034W Fatty acid elongase, involved in sphingolipid biosynthesis genetic 1 1 1 Negative Genetic
DIA4 YHR011W Probable mitochondrial seryl-tRNA synthetase genetic 1 1 1 Negative Genetic
RBK1 YCR036W Ribokinase, phosphorylates ribose to ribose-5-phosphate genetic 1 1 1 Positive Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
PDB1 YBR221C E1 beta subunit of the pyruvate dehydrogenase (PDH) complex genetic 1 1 1 Positive Genetic
FEN2 YCR028C Plasma membrane H+-pantothenate symporter genetic 1 1 1 Negative Genetic
MED8 YBR193C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Positive Genetic
FIP1 YJR093C Subunit of cleavage polyadenylation factor (CPF) genetic 1 1 1 Positive Genetic
SMD2 YLR275W Core Sm protein Sm D2 genetic 1 1 1 Positive Genetic
TIF6 YPR016C Constituent of 66S pre-ribosomal particles genetic 1 1 1 Positive Genetic
KAP104 YBR017C Transportin or cytosolic karyopherin beta 2 genetic 1 1 1 Positive Genetic
MRP20 YDR405W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
GTA1 YEL043W Protein of unknown function genetic 1 1 1 Positive Genetic
MIN10 YFR032C-B Mitochondrial protein of unknown function genetic 1 1 1 Positive Genetic
TIF2 YJL138C Translation initiation factor eIF4A genetic 1 1 1 Positive Genetic
MRM2 YGL136C Mitochondrial 2' O-ribose methyltransferase genetic 1 1 1 Positive Genetic
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Positive Genetic
LIP5 YOR196C Protein involved in biosynthesis of the coenzyme lipoic acid genetic 1 1 1 Positive Genetic
MCT1 YOR221C Predicted malonyl-CoA:ACP transferase genetic 1 1 1 Positive Genetic
IPP1 YBR011C Cytoplasmic inorganic pyrophosphatase (PPase) genetic 1 1 1 Negative Genetic
KIN28 YDL108W Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly genetic 1 1 1 Negative Genetic
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex genetic 1 1 1 Negative Genetic
NSE3 YDR288W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
TLG1 YDR468C Essential t-SNARE that mediates fusion of vesicles with the late Golgi genetic 1 1 1 Negative Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l genetic 1 1 1 Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
SFH1 YLR321C Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
PRP24 YMR268C Splicing factor that reanneals snRNPs during spliceosome recycling genetic 1 1 1 Negative Genetic
COG4 YPR105C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Negative Genetic
MET8 YBR213W Bifunctional dehydrogenase and ferrochelatase genetic 1 1 1 Negative Genetic
MRX14 YDR115W Putative mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
YDR194W-A YDR194W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
UBC6 YER100W Ubiquitin-conjugating enzyme involved in ERAD genetic 1 1 1 Negative Genetic
OXA1 YER154W Mitochondrial inner membrane insertase genetic 1 1 1 Negative Genetic
GCG1 YER163C Gamma-glutamyl cyclotransferase genetic 1 1 1 Negative Genetic
YGR273C YGR273C Putative protein of unknown function genetic 1 1 1 Negative Genetic
SFB3 YHR098C Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat genetic 1 1 1 Negative Genetic
MRPL6 YHR147C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
PET130 YJL023C Protein of unknown function genetic 1 1 1 Negative Genetic
MRPL49 YJL096W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
VPS55 YJR044C Late endosomal protein involved in late endosome to vacuole transport genetic 1 1 1 Negative Genetic
IRC25 YLR021W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 1 1 1 Negative Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Negative Genetic
QRI5 YLR204W Mitochondrial inner membrane protein genetic 1 1 1 Negative Genetic
NDL1 YLR254C Homolog of nuclear distribution factor NudE genetic 1 1 1 Negative Genetic
ERG24 YNL280C C-14 sterol reductase genetic 1 1 1 Negative Genetic
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Negative Genetic
VPS41 YDR080W Subunit of the HOPS endocytic tethering complex genetic 1 1 1 Negative Genetic
SAC3 YDR159W mRNA export factor genetic 1 1 1 Negative Genetic
IES5 YER092W Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Negative Genetic
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 1 1 1 Negative Genetic
YGR050C YGR050C Protein of unknown function genetic 1 1 1 Negative Genetic
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 1 1 1 Negative Genetic
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
YJR011C YJR011C Putative protein of unknown function genetic 1 1 1 Negative Genetic
PTK2 YJR059W Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Negative Genetic
YJU3 YKL094W Monoglyceride lipase (MGL) that hydrolyzes fatty acid ethyl esters genetic 1 1 1 Negative Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Negative Genetic
UBI4 YLL039C Ubiquitin genetic 1 1 1 Negative Genetic
VPS9 YML097C Guanine nucleotide exchange factor (GEF) and ubiquitin receptor genetic 1 1 1 Negative Genetic
TRI1 YMR233W Non-essential sumoylated protein of unknown function genetic 1 1 1 Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 1 1 1 Negative Genetic
NEW1 YPL226W Translation termination and ribosome biogenesis factor genetic 1 1 1 Negative Genetic
PDH1 YPR002W Putative 2-methylcitrate dehydratase genetic 1 1 1 Negative Genetic
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SUE1 YPR151C Protein required for degradation of unstable forms of cytochrome c genetic 1 1 1 Negative Genetic
YOL057W YOL057W Dipeptidyl-peptidase III genetic 1 1 1 Negative Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Negative Genetic
HAL1 YPR005C Cytoplasmic protein involved in halotolerance genetic 1 1 1 Negative Genetic
JID1 YPR061C Probable Hsp40p co-chaperone genetic 1 1 1 Negative Genetic
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Negative Genetic
CSE4 YKL049C Centromeric histone H3-like protein genetic 1 1 1 Positive Genetic
GSH1 YJL101C Gamma glutamylcysteine synthetase genetic 1 1 1 Synthetic Rescue
CRD1 YDL142C Cardiolipin synthase genetic 1 1 1 Synthetic Growth Defect
CEM1 YER061C Mitochondrial beta-keto-acyl synthase genetic 1 1 1 Positive Genetic