Standard name Systematic name Name description Description
CIT2 YCR005C Citrate synthase, peroxisomal isozyme involved in glyoxylate cycle Citrate synthase, peroxisomal isozyme involved in glyoxylate cycle; catalyzes condensation of acetyl coenzyme A and oxaloacetate to form citrate; expression is controlled by Rtg1p and Rtg2p transcription factors; SCF-Ucc1 regulates level of Cit2p to maintain citrate homeostasis; oxaloacetate-dependent positive feedback loop inhibits Cit2p ubiquitination; CIT2 has a paralog, CIT1, that arose from the whole genome duplication
Visualize the interactome of CIT2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1(P) 35

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.954 0.980 0.975
Mito NaN 0.069 0.092

GFP localization & abundance

GFP localization GFP abundance
cytoplasm 2310

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
CIT2 2 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0301 (citrate synthase, peroxisomal)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
CIT1 YNR001C Mitochondrial citrate synthase genetic 13 4 11 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Enhancement
FKH1 YIL131C Forkhead family transcription factor regulation 4 3 4 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
CIT2 YCR005C Citrate synthase, peroxisomal isozyme involved in glyoxylate cycle physical 4 2 4 Two-hybrid, PCA, PCA, PCA
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex genetic 4 2 3 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect
LAT1 YNL071W Dihydrolipoamide acetyltransferase component (E2) of the PDC genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
UCC1 YLR224W F-box protein and component of SCF ubiquitin ligase complexes physical 4 3 2 Biochemical Activity, Two-hybrid, Affinity Capture-Western, Biochemical Activity
FKH2 YNL068C Forkhead family transcription factor regulation 3 2 3 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
PDB1 YBR221C E1 beta subunit of the pyruvate dehydrogenase (PDH) complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex regulation 2 2 2 chromatin immunoprecipitation-chip evidence, DNA to cDNA expression microarray evidence
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways regulation 2 2 2 DNA to cDNA expression microarray evidence, quantitative reverse transcription polymerase chain reaction evidence
CIT3 YPR001W Dual specificity mitochondrial citrate and methylcitrate synthase genetic 2 2 2 Synthetic Lethality, Phenotypic Enhancement
CRD1 YDL142C Cardiolipin synthase genetic 2 2 2 Negative Genetic, Synthetic Lethality
IDH1 YNL037C Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase genetic 2 2 2 Positive Genetic, Dosage Growth Defect
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
PDX1 YGR193C E3-binding protein of the mitochondrial pyruvate dehydrogenase complex genetic 2 1 2 Negative Genetic, Negative Genetic
YFH1 YDL120W Mitochondrial matrix iron chaperone genetic 2 2 1 Dosage Lethality, Synthetic Rescue
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis regulation 1 1 1 DNA to cDNA expression microarray evidence
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis regulation 1 1 1 DNA to cDNA expression microarray evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MET32 YDR253C Zinc-finger DNA-binding transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MET4 YNL103W Leucine-zipper transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MSN2 YMR037C Stress-responsive transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT20 YOL148C Subunit of the SAGA transcriptional regulatory complex regulation 1 1 1 DNA to cDNA expression microarray evidence
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci regulation 1 1 1 DNA to cDNA expression microarray evidence
STP1 YDR463W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT7 YBR081C Subunit of the SAGA transcriptional regulatory complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BAS1 YKR099W Myb-related transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
UME6 YDR207C Rpd3L histone deacetylase complex subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CST6 YIL036W Basic leucine zipper (bZIP) transcription factor from ATF/CREB family regulation 1 1 1 DNA to cDNA expression microarray evidence
TUP1 YCR084C General repressor of transcription in complex with Cyc8p regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ADA2 YDR448W Transcription coactivator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SRB5 YGR104C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
USV1 YPL230W Putative transcription factor containing a C2H2 zinc finger regulation 1 1 1 northern blot evidence
OPI1 YHL020C Transcriptional regulator of a variety of genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ADH1 YOL086C Alcohol dehydrogenase genetic 1 1 1 Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Positive Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Dosage Lethality
ACO1 YLR304C Aconitase genetic 1 1 1 Negative Genetic
ACH1 YBL015W Protein with CoA transferase activity genetic 1 1 1 Synthetic Growth Defect
CAT5 YOR125C Protein required for ubiquinone (Coenzyme Q) biosynthesis genetic 1 1 1 Negative Genetic
ACS1 YAL054C Acetyl-coA synthetase isoform genetic 1 1 1 Synthetic Rescue
MHP1 YJL042W Microtubule-associated protein involved in microtubule organization physical 1 1 1 Two-hybrid
RTG2 YGL252C Sensor of mitochondrial dysfunction physical 1 1 1 Affinity Capture-Western
RTG2 YGL252C Sensor of mitochondrial dysfunction genetic 1 1 1 Dosage Rescue
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex physical 1 1 1 Affinity Capture-Western
MDH1 YKL085W Mitochondrial malate dehydrogenase physical 1 1 1 Reconstituted Complex
MDH1 YKL085W Mitochondrial malate dehydrogenase genetic 1 1 1 Synthetic Lethality
PRO2 YOR323C Gamma-glutamyl phosphate reductase physical 1 1 1 Affinity Capture-MS
UBI4 YLL039C Ubiquitin physical 1 1 1 Affinity Capture-MS
MIC60 YKR016W Component of the MICOS complex physical 1 1 1 Affinity Capture-MS
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
SRP54 YPR088C Signal recognition particle (SRP) subunit (homolog of mammalian SRP54) physical 1 1 1 Co-purification
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
COX4 YGL187C Subunit IV of cytochrome c oxidase physical 1 1 1 Affinity Capture-MS
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
HSP104 YLL026W Disaggregase physical 1 1 1 Affinity Capture-MS
SPO22 YIL073C Meiosis-specific protein essential for chromosome synapsis physical 1 1 1 Affinity Capture-MS
SPO16 YHR153C Meiosis-specific protein involved in synaptonemal complex assembly physical 1 1 1 Affinity Capture-MS
MDH3 YDL078C Peroxisomal malate dehydrogenase genetic 1 1 1 Phenotypic Enhancement
YAT1 YAR035W Outer mitochondrial carnitine acetyltransferase genetic 1 1 1 Synthetic Growth Defect
YAT2 YER024W Carnitine acetyltransferase genetic 1 1 1 Synthetic Growth Defect
RAS1 YOR101W GTPase involved in G-protein signaling in adenylate cyclase activation genetic 1 1 1 Dosage Rescue
OAC1 YKL120W Mitochondrial inner membrane transporter genetic 1 1 1 Synthetic Lethality
SYM1 YLR251W Protein required for ethanol metabolism genetic 1 1 1 Synthetic Growth Defect
PHB1 YGR132C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 1 1 1 Negative Genetic
MCA1 YOR197W Ca2+-dependent cysteine protease genetic 1 1 1 Synthetic Rescue
LEU5 YHR002W Mitochondrial carrier protein genetic 1 1 1 Negative Genetic
PDX3 YBR035C Pyridoxine (pyridoxamine) phosphate oxidase genetic 1 1 1 Positive Genetic
COX5A YNL052W Subunit Va of cytochrome c oxidase genetic 1 1 1 Positive Genetic
HFA1 YMR207C Mitochondrial acetyl-coenzyme A carboxylase genetic 1 1 1 Negative Genetic
PYC2 YBR218C Pyruvate carboxylase isoform genetic 1 1 1 Positive Genetic
HTD2 YHR067W Mitochondrial 3-hydroxyacyl-thioester dehydratase genetic 1 1 1 Negative Genetic
YML082W YML082W Putative protein predicted to have carbon-sulfur lyase activity genetic 1 1 1 Positive Genetic
COQ9 YLR201C Protein required for ubiquinone biosynthesis and respiratory growth genetic 1 1 1 Negative Genetic
IDH2 YOR136W Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase genetic 1 1 1 Positive Genetic
SPE1 YKL184W Ornithine decarboxylase genetic 1 1 1 Positive Genetic
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) genetic 1 1 1 Negative Genetic
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 1 1 1 Negative Genetic
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Rescue
RIO2 YNL207W Essential serine kinase involved in the processing of 20S pre-rRNA genetic 1 1 1 Positive Genetic
PRE7 YBL041W Beta 6 subunit of the 20S proteasome genetic 1 1 1 Positive Genetic
LUC7 YDL087C Essential protein associated with the U1 snRNP complex genetic 1 1 1 Positive Genetic
CSE4 YKL049C Centromeric histone H3-like protein genetic 1 1 1 Positive Genetic
SNU114 YKL173W GTPase component of U5 snRNP involved in mRNA splicing via spliceosome genetic 1 1 1 Positive Genetic
UTP15 YMR093W Nucleolar protein genetic 1 1 1 Positive Genetic
UFD4 YKL010C Ubiquitin-protein ligase (E3) genetic 1 1 1 Positive Genetic
PEX17 YNL214W Membrane peroxin of the peroxisomal importomer complex genetic 1 1 1 Positive Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Positive Genetic
PTI1 YGR156W Essential component of CPF (cleavage and polyadenylation factor) genetic 1 1 1 Negative Genetic
YKT6 YKL196C Vesicle membrane protein (v-SNARE) with acyltransferase activity genetic 1 1 1 Negative Genetic
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
HSP10 YOR020C Mitochondrial matrix co-chaperonin genetic 1 1 1 Negative Genetic
MAK5 YBR142W Essential nucleolar protein genetic 1 1 1 Negative Genetic
MED8 YBR193C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 1 1 1 Negative Genetic
GLE1 YDL207W Cytoplasmic nucleoporin required for polyadenylated mRNA export genetic 1 1 1 Negative Genetic
TIM22 YDL217C Essential core component of mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
TAF6 YGL112C Subunit (60 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Negative Genetic
MES1 YGR264C Methionyl-tRNA synthetase genetic 1 1 1 Negative Genetic
MED6 YHR058C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
DPB11 YJL090C DNA replication initiation protein genetic 1 1 1 Negative Genetic
SDS22 YKL193C Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p genetic 1 1 1 Negative Genetic
PRP19 YLL036C Splicing factor associated with the spliceosome genetic 1 1 1 Negative Genetic
SED5 YLR026C cis-Golgi t-SNARE syntaxin genetic 1 1 1 Negative Genetic
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
TAD3 YLR316C Subunit of tRNA-specific adenosine-34 deaminase genetic 1 1 1 Negative Genetic
NBP1 YLR457C Spindle pole body (SPB) component genetic 1 1 1 Negative Genetic
TAF11 YML015C TFIID subunit (40 kDa) genetic 1 1 1 Negative Genetic
SEC65 YML105C Subunit of the signal recognition particle (SRP) genetic 1 1 1 Negative Genetic
PGA3 YML125C Putative cytochrome b5 reductase, localized to the plasma membrane genetic 1 1 1 Negative Genetic
LST8 YNL006W Protein required for the transport of Gap1p genetic 1 1 1 Negative Genetic
OST2 YOR103C Epsilon subunit of the oligosaccharyltransferase complex genetic 1 1 1 Negative Genetic
RPO31 YOR116C RNA polymerase III largest subunit C160 genetic 1 1 1 Negative Genetic
SEC8 YPR055W Essential 121 kDa subunit of the exocyst complex genetic 1 1 1 Negative Genetic
SUA7 YPR086W Transcription factor TFIIB genetic 1 1 1 Negative Genetic
SCO1 YBR037C Copper-binding protein of mitochondrial inner membrane genetic 1 1 1 Negative Genetic
YHR050W-A YHR050W-A Protein of unknown function genetic 1 1 1 Negative Genetic
COX6 YHR051W Subunit VI of cytochrome c oxidase (Complex IV) genetic 1 1 1 Negative Genetic
FMC1 YIL098C Mitochondrial matrix protein genetic 1 1 1 Negative Genetic
COA3 YJL062W-A Mitochondrial protein required for cytochrome c oxidase assembly genetic 1 1 1 Negative Genetic
QCR8 YJL166W Subunit 8 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Negative Genetic
SEG2 YKL105C Eisosome component genetic 1 1 1 Negative Genetic
CYT1 YOR065W Cytochrome c1 genetic 1 1 1 Negative Genetic
COX10 YPL172C Heme A:farnesyltransferase genetic 1 1 1 Negative Genetic
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Positive Genetic
PEX34 YCL056C Protein that regulates peroxisome populations genetic 1 1 1 Phenotypic Suppression
BOS1 YLR078C v-SNARE (vesicle specific SNAP receptor) genetic 1 1 1 Negative Genetic
BET1 YIL004C Type II membrane protein required for vesicular transport genetic 1 1 1 Negative Genetic
ATG2 YNL242W Peripheral membrane protein required for autophagic vesicle formation genetic 1 1 1 Negative Genetic
CAT2 YML042W Carnitine acetyl-CoA transferase genetic 1 1 1 Synthetic Growth Defect
AGC1 YPR021C Mitochondrial amino acid transporter genetic 1 1 1 Phenotypic Enhancement