Standard name Systematic name Name description Description
SCO1 YBR037C Copper-binding protein of mitochondrial inner membrane Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication
Visualize the interactome of SCO1
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm NaN 0.050 NaN
Mito NaN 0.815 0.931
Vac/Vac Memb NaN 0.190 0.069

GFP localization & abundance

GFP localization GFP abundance
mitochondrion 2550

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SCO1 0 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
FKH2 YNL068C Forkhead family transcription factor regulation 6 3 6 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, ChEC-Seq experiments
COX2 Q0250 Subunit II of cytochrome c oxidase (Complex IV) physical 3 3 3 Affinity Capture-Western, Co-fractionation, Co-purification
PUF3 YLL013C Protein of the mitochondrial outer surface physical 3 1 3 Affinity Capture-RNA, Affinity Capture-RNA, Affinity Capture-RNA
ERG3 YLR056W C-5 sterol desaturase genetic 3 1 3 Positive Genetic, Positive Genetic, Positive Genetic
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase genetic 3 2 2 Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect
FKH1 YIL131C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation genetic 2 2 2 Phenotypic Suppression, Negative Genetic
COX17 YLL009C Copper metallochaperone that transfers copper to Sco1p and Cox11p physical 2 2 2 Biochemical Activity, Affinity Capture-Western
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
AEP2 YMR282C Mitochondrial protein genetic 2 1 2 Negative Genetic, Negative Genetic
PAA1 YDR071C Polyamine acetyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
RXT3 YDL076C Component of the Rpd3L histone deacetylase complex genetic 2 1 2 Positive Genetic, Positive Genetic
PFK2 YMR205C Beta subunit of heterooctameric phosphofructokinase genetic 2 1 2 Negative Genetic, Negative Genetic
FYV10 YIL097W Subunit of GID complex genetic 2 1 2 Negative Genetic, Negative Genetic
ROD1 YOR018W Alpha-arrestin involved in ubiquitin-dependent endocytosis genetic 2 1 2 Positive Genetic, Positive Genetic
MDR1 YGR100W Cytoplasmic GTPase-activating protein genetic 2 1 2 Negative Genetic, Negative Genetic
AMD1 YML035C AMP deaminase genetic 2 1 2 Positive Genetic, Positive Genetic
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component genetic 2 1 2 Negative Genetic, Negative Genetic
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex genetic 2 1 2 Negative Genetic, Negative Genetic
URM1 YIL008W Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs genetic 2 1 2 Positive Genetic, Positive Genetic
SRN2 YLR119W Component of the ESCRT-I complex genetic 2 1 2 Negative Genetic, Negative Genetic
UPS1 YLR193C Phosphatidic acid transfer protein genetic 2 1 2 Negative Genetic, Negative Genetic
SEC72 YLR292C Non-essential subunit of Sec63 complex genetic 2 1 2 Negative Genetic, Negative Genetic
SIP5 YMR140W Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
GPB2 YAL056W Multistep regulator of cAMP-PKA signaling genetic 2 1 2 Negative Genetic, Negative Genetic
ATP10 YLR393W Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase genetic 2 1 2 Negative Genetic, Negative Genetic
COX17 YLL009C Copper metallochaperone that transfers copper to Sco1p and Cox11p genetic 2 1 2 Dosage Rescue, Dosage Rescue
HSV2 YGR223C Phosphatidylinositol 3,5-bisphosphate-binding protein genetic 2 1 2 Positive Genetic, Positive Genetic
MHP1 YJL042W Microtubule-associated protein involved in microtubule organization genetic 2 1 2 Negative Genetic, Negative Genetic
ATP18 YML081C-A Subunit of the mitochondrial F1F0 ATP synthase genetic 2 1 2 Negative Genetic, Negative Genetic
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit genetic 2 1 2 Positive Genetic, Positive Genetic
ATP23 YNR020C Putative metalloprotease of the mitochondrial inner membrane genetic 2 1 2 Negative Genetic, Negative Genetic
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED6 YHR058C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
RPS4B YHR203C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
ARP9 YMR033W Component of both the SWI/SNF and RSC chromatin remodeling complexes genetic 1 1 1 Negative Genetic
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
ABD1 YBR236C Methyltransferase genetic 1 1 1 Negative Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CLP1 YOR250C Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Negative Genetic
COX4 YGL187C Subunit IV of cytochrome c oxidase physical 1 1 1 Affinity Capture-MS
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 1 1 1 Negative Genetic
FTH1 YBR207W Putative high affinity iron transporter genetic 1 1 1 Negative Genetic
BDF2 YDL070W Protein involved in transcription initiation genetic 1 1 1 Positive Genetic
LST8 YNL006W Protein required for the transport of Gap1p genetic 1 1 1 Negative Genetic
MED6 YHR058C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MRP20 YDR405W Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Proximity Label-MS
IES1 YFL013C Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Positive Genetic
MRPL15 YLR312W-A Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Proximity Label-MS
PCF11 YDR228C mRNA 3' end processing factor genetic 1 1 1 Negative Genetic
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 1 1 1 Negative Genetic
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Lethality
PRP4 YPR178W Splicing factor genetic 1 1 1 Negative Genetic
PUB1 YNL016W Poly (A)+ RNA-binding protein physical 1 1 1 Affinity Capture-MS
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
RCO1 YMR075W Essential component of the Rpd3S histone deacetylase complex genetic 1 1 1 Negative Genetic
CTI6 YPL181W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
SAK1 YER129W Upstream serine/threonine kinase for the SNF1 complex genetic 1 1 1 Negative Genetic
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Positive Genetic
NTE1 YML059C Serine esterase genetic 1 1 1 Positive Genetic
PHO84 YML123C High-affinity inorganic phosphate (Pi) transporter genetic 1 1 1 Negative Genetic
HIR3 YJR140C Subunit of the HIR complex genetic 1 1 1 Positive Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Negative Genetic
BUD13 YGL174W Subunit of the RES complex genetic 1 1 1 Negative Genetic
GAC1 YOR178C Regulatory subunit for Glc7p type-1 protein phosphatase (PP1) genetic 1 1 1 Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
GLE1 YDL207W Cytoplasmic nucleoporin required for polyadenylated mRNA export genetic 1 1 1 Negative Genetic
AFR1 YDR085C Protein required for pheromone-induced projection (shmoo) formation genetic 1 1 1 Negative Genetic
HIR2 YOR038C Subunit of HIR nucleosome assembly complex genetic 1 1 1 Negative Genetic
KSS1 YGR040W Mitogen-activated protein kinase (MAPK) genetic 1 1 1 Negative Genetic
PCL6 YER059W Pho85p cyclin of the Pho80p subfamily genetic 1 1 1 Positive Genetic
FUB1 YCR076C Proteasome-binding protein genetic 1 1 1 Negative Genetic
MEH1 YKR007W Subunit of the EGO/GSE complex genetic 1 1 1 Positive Genetic
RIM11 YMR139W Protein kinase genetic 1 1 1 Negative Genetic
CMG1 YLR271W Putative protein of unknown function genetic 1 1 1 Negative Genetic
EXO70 YJL085W Subunit of the exocyst complex genetic 1 1 1 Positive Genetic
DCK1 YLR422W Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1 genetic 1 1 1 Negative Genetic
ARP1 YHR129C Actin-related protein of the dynactin complex genetic 1 1 1 Synthetic Lethality
CIT2 YCR005C Citrate synthase, peroxisomal isozyme involved in glyoxylate cycle genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
BAS1 YKR099W Myb-related transcription factor genetic 1 1 1 Negative Genetic
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 1 1 1 Negative Genetic
CRP1 YHR146W Protein that binds to cruciform DNA structures genetic 1 1 1 Negative Genetic
CBF2 YGR140W Essential kinetochore protein genetic 1 1 1 Negative Genetic
GOS1 YHL031C v-SNARE protein involved in Golgi transport genetic 1 1 1 Negative Genetic
GAL80 YML051W Transcriptional regulator involved in the repression of GAL genes genetic 1 1 1 Negative Genetic
SCO2 YBR024W Protein anchored to mitochondrial inner membrane physical 1 1 1 Reconstituted Complex
SCO2 YBR024W Protein anchored to mitochondrial inner membrane genetic 1 1 1 Dosage Rescue
SCO1 YBR037C Copper-binding protein of mitochondrial inner membrane physical 1 1 1 Reconstituted Complex
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
TIM23 YNR017W Essential component of the TIM23 complex physical 1 1 1 Affinity Capture-MS
STR2 YJR130C Cystathionine gamma-synthase, converts cysteine into cystathionine genetic 1 1 1 Dosage Rescue
YJR120W YJR120W Protein of unknown function genetic 1 1 1 Negative Genetic
YOL013W-A YOL013W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
WHI5 YOR083W Repressor of G1 transcription genetic 1 1 1 Negative Genetic
VHS1 YDR247W Cytoplasmic serine/threonine protein kinase genetic 1 1 1 Positive Genetic
YDR248C YDR248C Putative gluconokinase genetic 1 1 1 Positive Genetic
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit genetic 1 1 1 Positive Genetic
YLR125W YLR125W Putative protein of unknown function genetic 1 1 1 Positive Genetic
YML100W-A YML100W-A Putative protein of unknown function genetic 1 1 1 Positive Genetic
SWS2 YNL081C Putative mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Positive Genetic
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex genetic 1 1 1 Positive Genetic
TIM22 YDL217C Essential core component of mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
TCP1 YDR212W Alpha subunit of chaperonin-containing T-complex genetic 1 1 1 Negative Genetic
YPT1 YFL038C Rab family GTPase genetic 1 1 1 Negative Genetic
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin genetic 1 1 1 Negative Genetic
STS1 YIR011C Protein required for localizing proteasomes to the nucleus genetic 1 1 1 Negative Genetic
SSL1 YLR005W Subunit of the core form of RNA polymerase transcription factor TFIIH genetic 1 1 1 Negative Genetic
YHC1 YLR298C Component of the U1 snRNP complex required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
TAD3 YLR316C Subunit of tRNA-specific adenosine-34 deaminase genetic 1 1 1 Negative Genetic
SRV2 YNL138W CAP (cyclase-associated protein) genetic 1 1 1 Negative Genetic
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 1 1 1 Negative Genetic
YAL065C YAL065C Putative protein of unknown function genetic 1 1 1 Negative Genetic
THI3 YDL080C Regulatory protein that binds Pdc2p and Thi2p transcription factors genetic 1 1 1 Negative Genetic
YFL051C YFL051C Putative protein of unknown function genetic 1 1 1 Negative Genetic
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 1 1 1 Negative Genetic
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SMF2 YHR050W Divalent metal ion transporter involved in manganese homeostasis genetic 1 1 1 Negative Genetic
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
TAX4 YJL083W EH domain-containing protein genetic 1 1 1 Negative Genetic
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 1 1 1 Negative Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Negative Genetic
TGL4 YKR089C Multifunctional lipase/hydrolase/phospholipase genetic 1 1 1 Negative Genetic
TPP1 YMR156C DNA 3'-phosphatase genetic 1 1 1 Negative Genetic
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 1 1 1 Negative Genetic
SIW14 YNL032W Inositol phosphatase involved in inositol pyrophosphate metabolism genetic 1 1 1 Negative Genetic
TOM7 YNL070W Component of the TOM (translocase of outer membrane) complex genetic 1 1 1 Negative Genetic
SGT2 YOR007C Glutamine-rich cytoplasmic cochaperone genetic 1 1 1 Negative Genetic
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 1 1 1 Negative Genetic
STD1 YOR047C Protein involved in control of glucose-regulated gene expression genetic 1 1 1 Negative Genetic
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Negative Genetic
UME1 YPL139C Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 1 1 1 Negative Genetic
RER1 YCL001W Protein involved in retention of membrane proteins genetic 1 1 1 Negative Genetic
PAM16 YJL104W Subunit of the import motor (PAM complex) genetic 1 1 1 Negative Genetic
OXA1 YER154W Mitochondrial inner membrane insertase physical 1 1 1 Proximity Label-MS
GPB1 YOR371C Multistep regulator of cAMP-PKA signaling genetic 1 1 1 Negative Genetic
COX15 YER141W Heme a synthase genetic 1 1 1 Dosage Growth Defect
MBA1 YBR185C Membrane-associated mitochondrial ribosome receptor physical 1 1 1 Proximity Label-MS
RSM25 YIL093C Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
RTT109 YLL002W Histone acetyltransferase genetic 1 1 1 Negative Genetic
MSS51 YLR203C Specific translational activator for the mitochondrial COX1 mRNA physical 1 1 1 Proximity Label-MS
PHO13 YDL236W Conserved phosphatase acting as a metabolite repair enzyme genetic 1 1 1 Positive Genetic
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPL43A YPR043W Ribosomal 60S subunit protein L43A genetic 1 1 1 Negative Genetic
NUP192 YJL039C Essential subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
IGD1 YFR017C Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity genetic 1 1 1 Negative Genetic
PTK2 YJR059W Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
CYT1 YOR065W Cytochrome c1 genetic 1 1 1 Positive Genetic
COX11 YPL132W Protein required for delivery of copper to Cox1p genetic 1 1 1 Dosage Rescue
CTA1 YDR256C Catalase A genetic 1 1 1 Dosage Rescue
DFG16 YOR030W Probable multiple transmembrane protein genetic 1 1 1 Positive Genetic
MRL1 YPR079W Membrane protein physical 1 1 1 PCA
MRN1 YPL184C RNA-binding protein that may be involved in translational regulation genetic 1 1 1 Negative Genetic
CTT1 YGR088W Cytosolic catalase T genetic 1 1 1 Dosage Rescue
AVL9 YLR114C Conserved protein involved in exocytic transport from the Golgi genetic 1 1 1 Positive Genetic
COX20 YDR231C Mitochondrial inner membrane protein physical 1 1 1 Affinity Capture-Western
QRI1 YDL103C UDP-N-acetylglucosamine pyrophosphorylase genetic 1 1 1 Negative Genetic
MPC1 YGL080W Highly conserved subunit of mitochondrial pyruvate carrier (MPC) genetic 1 1 1 Negative Genetic
MXR2 YCL033C Methionine-R-sulfoxide reductase genetic 1 1 1 Negative Genetic
MDM35 YKL053C-A Mitochondrial intermembrane space protein genetic 1 1 1 Positive Genetic
MSC1 YML128C Protein of unknown function genetic 1 1 1 Negative Genetic
AFG1 YEL052W Protein that may act as a chaperone for cytochrome c oxidase subunits genetic 1 1 1 Dosage Rescue
PMP3 YDR276C Small plasma membrane protein genetic 1 1 1 Negative Genetic
FRE2 YKL220C Ferric reductase and cupric reductase genetic 1 1 1 Negative Genetic
PIG2 YIL045W Putative type-1 protein phosphatase targeting subunit genetic 1 1 1 Negative Genetic
COA6 YMR244C-A Protein involved in cytochrome c oxidase (Complex IV) assembly physical 1 1 1 Affinity Capture-Western
COA6 YMR244C-A Protein involved in cytochrome c oxidase (Complex IV) assembly genetic 1 1 1 Dosage Rescue
ATP23 YNR020C Putative metalloprotease of the mitochondrial inner membrane physical 1 1 1 Affinity Capture-MS
PAU11 YGL261C Putative protein of unknown function genetic 1 1 1 Negative Genetic
RTC5 YOR118W Protein of unknown function genetic 1 1 1 Negative Genetic