| Standard name | Systematic name | Name description | Description |
|---|---|---|---|
| TGL4 | YKR089C | Multifunctional lipase/hydrolase/phospholipase | Multifunctional lipase/hydrolase/phospholipase; triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p; TGL4 has a paralog, TGL5, that arose from the whole genome duplication |
Cell cycle phase and timing of transcription peak
| Cell cycle phase | Time (min) |
|---|---|
CYCLoPs localization & abundance
| WT1 | WT2 | WT3 | |
|---|---|---|---|
| Cytoplasm | 0.057 | NaN | NaN |
| Endosome | 0.272 | 0.271 | 0.395 |
| Mito | 0.341 | 0.402 | 0.160 |
| Nucleolus | 0.290 | 0.157 | 0.096 |
| Peroxisome | 0.228 | 0.380 | 0.203 |
| SpindlePole | 0.350 | 0.230 | 0.502 |
| Nuc Periphery | NaN | 0.081 | NaN |
GFP localization & abundance
| GFP localization | GFP abundance |
|---|---|
| no data | no data |
GO term count
| Metabolism | Cell cycle | Cell division | Signal transduction | DNA replication | |
|---|---|---|---|---|---|
| TGL4 | 5 | 0 | 2 | 0 | 0 |
Enzyme information
| Catalyzed reactions in Yeast8 |
|---|
| r_3282 (TAG lipase (1-16:0, 2-18:1, 3-18:0), lipid particle), r_3321 (PC phospholipase A2 (1-16:1, 2-18:1), lipid particle), r_3327 (PE phospholipase A2 (1-18:1, 2-16:1), lipid particle), r_3287 (TAG lipase (1-16:1, 2-18:1, 3-18:1), lipid particle), r_2341 (1-acyl-sn-glycerol-3-phosphate acyltransferase (1-16:1, 2-18:1), lipid particle), r_3268 (TAG lipase (1-16:1, 2-16:1, 3-16:0), lipid particle), r_3292 (TAG lipase (1-18:1, 2-18:1, 3-16:0), lipid particle), r_3273 (TAG lipase (1-18:0, 2-16:1, 3-16:1), lipid particle), r_3278 (TAG lipase (1-18:1, 2-16:1, 3-18:0), lipid particle), r_3316 (PC phospholipase A2 (1-16:0, 2-16:1), lipid particle), r_3322 (PC phospholipase A2 (1-18:0, 2-18:1), lipid particle), r_3328 (PE phospholipase A2 (1-16:0, 2-18:1), lipid particle), r_3283 (TAG lipase (1-16:0, 2-18:1, 3-18:1), lipid particle), r_3264 (TAG lipase (1-16:0, 2-16:1, 3-16:0), lipid particle), r_2342 (1-acyl-sn-glycerol-3-phosphate acyltransferase (1-18:0, 2-18:1), lipid particle), r_3288 (TAG lipase (1-18:0, 2-18:1, 3-16:0), lipid particle), r_3269 (TAG lipase (1-16:1, 2-16:1, 3-16:1), lipid particle), r_3293 (TAG lipase (1-18:1, 2-18:1, 3-16:1), lipid particle), r_3274 (TAG lipase (1-18:0, 2-16:1, 3-18:0), lipid particle), r_3317 (PC phospholipase A2 (1-16:1, 2-16:1), lipid particle), r_3323 (PC phospholipase A2 (1-18:1, 2-18:1), lipid particle), r_3329 (PE phospholipase A2 (1-16:1, 2-18:1), lipid particle), r_3279 (TAG lipase (1-18:1, 2-16:1, 3-18:1), lipid particle), r_3284 (TAG lipase (1-16:1, 2-18:1, 3-16:0), lipid particle), r_2343 (1-acyl-sn-glycerol-3-phosphate acyltransferase (1-18:1, 2-18:1), lipid particle), r_3265 (TAG lipase (1-16:0, 2-16:1, 3-16:1), lipid particle), r_3289 (TAG lipase (1-18:0, 2-18:1, 3-16:1), lipid particle), r_3270 (TAG lipase (1-16:1, 2-16:1, 3-18:0), lipid particle), r_3294 (TAG lipase (1-18:1, 2-18:1, 3-18:0), lipid particle), r_3277 (TAG lipase (1-18:1, 2-16:1, 3-16:1), lipid particle), r_3318 (PC phospholipase A2 (1-18:0, 2-16:1), lipid particle), r_3324 (PE phospholipase A2 (1-16:0, 2-16:1), lipid particle), r_3330 (PE phospholipase A2 (1-18:0, 2-18:1), lipid particle), r_3275 (TAG lipase (1-18:0, 2-16:1, 3-18:1), lipid particle), r_3280 (TAG lipase (1-16:0, 2-18:1, 3-16:0), lipid particle), r_3285 (TAG lipase (1-16:1, 2-18:1, 3-16:1), lipid particle), r_3266 (TAG lipase (1-16:0, 2-16:1, 3-18:0), lipid particle), r_3290 (TAG lipase (1-18:0, 2-18:1, 3-18:0), lipid particle), r_3319 (PC phospholipase A2 (1-18:1, 2-16:1), lipid particle), r_3325 (PE phospholipase A2 (1-16:1, 2-16:1), lipid particle), r_3331 (PE phospholipase A2 (1-18:1, 2-18:1), lipid particle), r_3271 (TAG lipase (1-16:1, 2-16:1, 3-18:1), lipid particle), r_3295 (TAG lipase (1-18:1, 2-18:1, 3-18:1), lipid particle), r_3276 (TAG lipase (1-18:1, 2-16:1, 3-16:0), lipid particle), r_3281 (TAG lipase (1-16:0, 2-18:1, 3-16:1), lipid particle), r_3286 (TAG lipase (1-16:1, 2-18:1, 3-18:0), lipid particle), r_3291 (TAG lipase (1-18:0, 2-18:1, 3-18:1), lipid particle), r_2340 (1-acyl-sn-glycerol-3-phosphate acyltransferase (1-16:0, 2-18:1), lipid particle), r_3320 (PC phospholipase A2 (1-16:0, 2-18:1), lipid particle), r_3326 (PE phospholipase A2 (1-18:0, 2-16:1), lipid particle), r_3267 (TAG lipase (1-16:0, 2-16:1, 3-18:1), lipid particle), r_3272 (TAG lipase (1-18:0, 2-16:1, 3-16:0), lipid particle) |
List of interactors
Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.| Standard name | Systematic name | Name description | Type | #Experiments | #Methods | #Publications | Evidence |
|---|---|---|---|---|---|---|---|
| TGL3 | YMR313C | Bifunctional triacylglycerol lipase and LPE acyltransferase | genetic | 3 | 2 | 2 | Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement |
| RPP2B | YDR382W | Ribosomal protein P2 beta | genetic | 3 | 1 | 2 | Negative Genetic, Negative Genetic, Negative Genetic |
| IRA2 | YOL081W | GTPase-activating protein | genetic | 3 | 1 | 2 | Negative Genetic, Negative Genetic, Negative Genetic |
| DOT1 | YDR440W | Nucleosomal histone H3-Lys79 methylase | genetic | 3 | 1 | 2 | Negative Genetic, Negative Genetic, Negative Genetic |
| PTH1 | YHR189W | One of two mitochondrially-localized peptidyl-tRNA hydrolases | genetic | 3 | 1 | 2 | Negative Genetic, Negative Genetic, Negative Genetic |
| FKH1 | YIL131C | Forkhead family transcription factor | regulation | 2 | 2 | 2 | chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments |
| DHH1 | YDL160C | Cytoplasmic DEAD-box helicase and mRNA decapping activator | physical | 2 | 1 | 2 | Affinity Capture-RNA, Affinity Capture-RNA |
| SGF29 | YCL010C | Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes | genetic | 2 | 1 | 2 | Negative Genetic, Negative Genetic |
| CAM1 | YPL048W | One of two isoforms of the gamma subunit of eEF1B | genetic | 2 | 1 | 2 | Negative Genetic, Negative Genetic |
| SLX5 | YDL013W | Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex | genetic | 2 | 1 | 2 | Negative Genetic, Negative Genetic |
| PPG1 | YNR032W | Serine protein phosphatase involved in formation of FAR complex | genetic | 2 | 1 | 2 | Negative Genetic, Negative Genetic |
| ERT1 | YBR239C | Transcriptional regulator | genetic | 2 | 1 | 2 | Negative Genetic, Negative Genetic |
| APT2 | YDR441C | Potential adenine phosphoribosyltransferase | genetic | 2 | 1 | 2 | Negative Genetic, Negative Genetic |
| GPM3 | YOL056W | Nonfunctional homolog of Gpm1p phosphoglycerate mutase | genetic | 2 | 1 | 2 | Negative Genetic, Negative Genetic |
| HPM1 | YIL110W | AdoMet-dependent methyltransferase | genetic | 2 | 1 | 2 | Negative Genetic, Negative Genetic |
| YOR1 | YGR281W | Plasma membrane ATP-binding cassette (ABC) transporter | genetic | 2 | 1 | 2 | Negative Genetic, Negative Genetic |
| NPL3 | YDR432W | RNA-binding protein | genetic | 2 | 2 | 1 | Synthetic Rescue, Synthetic Growth Defect |
| ACS2 | YLR153C | Acetyl-coA synthetase isoform | genetic | 2 | 1 | 1 | Synthetic Growth Defect, Synthetic Growth Defect |
| EAF6 | YJR082C | Subunit of the NuA4 acetyltransferase complex | genetic | 2 | 1 | 1 | Synthetic Growth Defect, Synthetic Growth Defect |
| APQ12 | YIL040W | Nuclear envelope/ER integral membrane protein | genetic | 2 | 1 | 1 | Negative Genetic, Negative Genetic |
| SPT10 | YJL127C | Histone H3 acetylase with a role in transcriptional regulation | regulation | 1 | 1 | 1 | quantitative reverse transcription polymerase chain reaction evidence |
| FKH2 | YNL068C | Forkhead family transcription factor | regulation | 1 | 1 | 1 | chromatin immunoprecipitation-chip evidence |
| CDC28 | YBR160W | Cyclin-dependent kinase (CDK) catalytic subunit | regulation | 1 | 1 | 1 | quantitative mass spectrometry evidence |
| SUA7 | YPR086W | Transcription factor TFIIB | regulation | 1 | 1 | 1 | chromatin immunoprecipitation-chip evidence |
| RVB2 | YPL235W | ATP-dependent DNA helicase, also known as reptin | physical | 1 | 1 | 1 | Affinity Capture-MS |
| CCR4 | YAL021C | Component of the CCR4-NOT transcriptional complex | physical | 1 | 1 | 1 | Affinity Capture-RNA |
| CDC28 | YBR160W | Cyclin-dependent kinase (CDK) catalytic subunit | physical | 1 | 1 | 1 | Biochemical Activity |
| CDC28 | YBR160W | Cyclin-dependent kinase (CDK) catalytic subunit | genetic | 1 | 1 | 1 | Phenotypic Suppression |
| CDC55 | YGL190C | Regulatory subunit B of protein phosphatase 2A (PP2A) | genetic | 1 | 1 | 1 | Phenotypic Enhancement |
| AVO1 | YOL078W | Component of the membrane-bound TORC2 complex | genetic | 1 | 1 | 1 | Negative Genetic |
| ISW1 | YBR245C | ATPase subunit of imitation-switch (ISWI) class chromatin remodelers | physical | 1 | 1 | 1 | Affinity Capture-RNA |
| CMD1 | YBR109C | Calmodulin | genetic | 1 | 1 | 1 | Negative Genetic |
| NHP10 | YDL002C | Non-essential INO80 chromatin remodeling complex subunit | genetic | 1 | 1 | 1 | Synthetic Growth Defect |
| PUB1 | YNL016W | Poly (A)+ RNA-binding protein | physical | 1 | 1 | 1 | Affinity Capture-MS |
| MAF1 | YDR005C | Highly conserved negative regulator of RNA polymerase III | genetic | 1 | 1 | 1 | Negative Genetic |
| SSE1 | YPL106C | ATPase component of heat shock protein Hsp90 chaperone complex | genetic | 1 | 1 | 1 | Negative Genetic |
| CMK1 | YFR014C | Calmodulin-dependent protein kinase | genetic | 1 | 1 | 1 | Dosage Growth Defect |
| HHT1 | YBR010W | Histone H3 | physical | 1 | 1 | 1 | Affinity Capture-MS |
| SWE1 | YJL187C | Protein kinase that regulates the G2/M transition | genetic | 1 | 1 | 1 | Phenotypic Suppression |
| RIM101 | YHL027W | Cys2His2 zinc-finger transcriptional repressor | genetic | 1 | 1 | 1 | Synthetic Lethality |
| QCR6 | YFR033C | Subunit 6 of the ubiquinol cytochrome-c reductase complex | genetic | 1 | 1 | 1 | Synthetic Growth Defect |
| SNF6 | YHL025W | Subunit of the SWI/SNF chromatin remodeling complex | genetic | 1 | 1 | 1 | Negative Genetic |
| RTG3 | YBL103C | bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways | genetic | 1 | 1 | 1 | Negative Genetic |
| MDM12 | YOL009C | Mitochondrial outer membrane protein, ERMES complex subunit | genetic | 1 | 1 | 1 | Negative Genetic |
| SCO1 | YBR037C | Copper-binding protein of mitochondrial inner membrane | genetic | 1 | 1 | 1 | Negative Genetic |
| ACF2 | YLR144C | Intracellular beta-1,3-endoglucanase | physical | 1 | 1 | 1 | PCA |
| HHT2 | YNL031C | Histone H3 | physical | 1 | 1 | 1 | Affinity Capture-MS |
| SDH1 | YKL148C | Flavoprotein subunit of succinate dehydrogenase | genetic | 1 | 1 | 1 | Negative Genetic |
| SLX8 | YER116C | Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex | genetic | 1 | 1 | 1 | Negative Genetic |
| RIM13 | YMR154C | Calpain-like cysteine protease | genetic | 1 | 1 | 1 | Synthetic Lethality |
| LGE1 | YPL055C | Protein involved in histone H2B ubiquitination | genetic | 1 | 1 | 1 | Synthetic Growth Defect |
| PET18 | YCR020C | Protein of unknown function | genetic | 1 | 1 | 1 | Negative Genetic |
| ATG15 | YCR068W | Phospholipase | genetic | 1 | 1 | 1 | Phenotypic Suppression |
| CRD1 | YDL142C | Cardiolipin synthase | genetic | 1 | 1 | 1 | Synthetic Lethality |
| SWF1 | YDR126W | Palmitoyltransferase that acts on transmembrane proteins | genetic | 1 | 1 | 1 | Negative Genetic |
| MMM1 | YLL006W | ER integral membrane protein, ERMES complex subunit | genetic | 1 | 1 | 1 | Negative Genetic |
| MCH5 | YOR306C | Plasma membrane riboflavin transporter | genetic | 1 | 1 | 1 | Negative Genetic |
| VAM6 | YDL077C | Guanine nucleotide exchange factor for the GTPase Gtr1p | physical | 1 | 1 | 1 | Affinity Capture-MS |
| USE1 | YGL098W | Essential SNARE protein localized to the ER | genetic | 1 | 1 | 1 | Negative Genetic |
| VPS1 | YKR001C | Dynamin-like GTPase required for vacuolar sorting | genetic | 1 | 1 | 1 | Synthetic Growth Defect |
| VPS5 | YOR069W | Nexin-1 homolog | genetic | 1 | 1 | 1 | Synthetic Growth Defect |
| YTA7 | YGR270W | Chromatin-binding ATPase that regulates histone gene expression | genetic | 1 | 1 | 1 | Synthetic Growth Defect |
| VHT1 | YGR065C | High-affinity plasma membrane H+-biotin (vitamin H) symporter | genetic | 1 | 1 | 1 | Negative Genetic |
| VPS4 | YPR173C | AAA-ATPase involved in multivesicular body (MVB) protein sorting | genetic | 1 | 1 | 1 | Phenotypic Suppression |
| SMA2 | YML066C | Meiosis-specific prospore membrane protein | genetic | 1 | 1 | 1 | Negative Genetic |