Standard name Systematic name Name description Description
SAK1 YER129W Upstream serine/threonine kinase for the SNF1 complex Upstream serine/threonine kinase for the SNF1 complex; plays a role in pseudohyphal growth; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome; SAK1 has a paralog, TOS3, that arose from the whole genome duplication
Visualize the interactome of SAK1
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.983 NaN 0.944
Mito NaN NaN 0.111

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SAK1 1 0 0 0 1

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SNF1 YDR477W AMP-activated S/T protein kinase physical 14 4 8 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Biochemical Activity, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Affinity Capture-Western, Affinity Capture-Western, Biochemical Activity
ELM1 YKL048C Serine/threonine protein kinase genetic 10 4 10 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement
TOS3 YGL179C Protein kinase genetic 8 3 8 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement
REG1 YDR028C Regulatory subunit of type 1 protein phosphatase Glc7p genetic 4 3 4 Synthetic Rescue, Positive Genetic, Synthetic Rescue, Phenotypic Suppression
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
PSO2 YMR137C Nuclease required for DNA single- and double-strand break repair physical 3 3 1 Two-hybrid, Biochemical Activity, Affinity Capture-Western
GAL83 YER027C One of three alternate beta-subunits of the Snf1 kinase complex physical 2 2 2 Affinity Capture-MS, Biochemical Activity
SIP1 YDR422C One of three alternate beta-subunits of the Snf1p kinase complex physical 2 2 2 Affinity Capture-MS, Biochemical Activity
SIP1 YDR422C One of three alternate beta-subunits of the Snf1p kinase complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SEC2 YNL272C Guanyl-nucleotide exchange factor for the small G-protein Sec4p genetic 2 2 2 Dosage Rescue, Negative Genetic
SAK1 YER129W Upstream serine/threonine kinase for the SNF1 complex physical 2 1 2 Biochemical Activity, Biochemical Activity
YKR018C YKR018C Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
COQ6 YGR255C Flavin-dependent monooxygenase involved in ubiquinone biosynthesis genetic 2 1 2 Negative Genetic, Negative Genetic
JID1 YPR061C Probable Hsp40p co-chaperone genetic 2 1 2 Negative Genetic, Negative Genetic
KIN82 YCR091W Putative serine/threonine protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
QCR8 YJL166W Subunit 8 of ubiquinol cytochrome-c reductase (Complex III) genetic 2 1 2 Negative Genetic, Negative Genetic
QCR9 YGR183C Subunit 9 of ubiquinol cytochrome-c reductase (Complex III) genetic 2 1 2 Negative Genetic, Negative Genetic
MSS2 YDL107W Peripherally bound inner membrane protein of the mitochondrial matrix genetic 2 1 2 Negative Genetic, Negative Genetic
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
CDC14 YFR028C Protein phosphatase required for mitotic exit physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
GPA1 YHR005C Subunit of G protein involved in pheromone response physical 2 2 1 Affinity Capture-Western, Biochemical Activity
HAP4 YKL109W Transcription factor genetic 2 2 1 Phenotypic Enhancement, Phenotypic Suppression
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
MRP49 YKL167C Mitochondrial ribosomal protein of the large subunit genetic 2 1 1 Negative Genetic, Negative Genetic
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
REG1 YDR028C Regulatory subunit of type 1 protein phosphatase Glc7p physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit regulation 1 1 1 quantitative mass spectrometry evidence
SNF1 YDR477W AMP-activated S/T protein kinase regulation 1 1 1 enzymatic activity assay evidence
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 qualitative western immunoblotting evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Negative Genetic
CKA2 YOR061W Alpha' catalytic subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
RPL10 YLR075W Ribosomal 60S subunit protein L10 genetic 1 1 1 Positive Genetic
GUS1 YGL245W Glutamyl-tRNA synthetase (GluRS) genetic 1 1 1 Negative Genetic
IML1 YJR138W GTPase-activating protein (GAP) subunit of the Iml1p/SEACIT complex genetic 1 1 1 Negative Genetic
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Rescue
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
REI1 YBR267W Cytoplasmic pre-60S factor genetic 1 1 1 Negative Genetic
AAH1 YNL141W Adenine deaminase (adenine aminohydrolase) genetic 1 1 1 Negative Genetic
KAP104 YBR017C Transportin or cytosolic karyopherin beta 2 genetic 1 1 1 Negative Genetic
BMS1 YPL217C GTPase required for ribosomal subunit synthesis and rRNA processing genetic 1 1 1 Positive Genetic
ARO1 YDR127W Pentafunctional arom protein genetic 1 1 1 Negative Genetic
BEM2 YER155C Rho GTPase activating protein (RhoGAP) physical 1 1 1 Affinity Capture-MS
BUD14 YAR014C Protein involved in bud-site selection genetic 1 1 1 Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 Biochemical Activity
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Dosage Lethality
COX6 YHR051W Subunit VI of cytochrome c oxidase (Complex IV) genetic 1 1 1 Negative Genetic
GCD7 YLR291C Beta subunit of translation initiation factor eIF2B genetic 1 1 1 Negative Genetic
IPP1 YBR011C Cytoplasmic inorganic pyrophosphatase (PPase) genetic 1 1 1 Negative Genetic
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
LST8 YNL006W Protein required for the transport of Gap1p genetic 1 1 1 Negative Genetic
HRR25 YPL204W Conserved casein kinase, monopolin subunit physical 1 1 1 Affinity Capture-MS
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 1 1 1 Dosage Rescue
BLM10 YFL007W Proteasome activator genetic 1 1 1 Positive Genetic
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 1 1 1 Negative Genetic
NUD1 YOR373W Mitotic exit network (MEN) scaffold protein physical 1 1 1 Affinity Capture-MS
MET18 YIL128W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Negative Genetic
RPB10 YOR210W RNA polymerase subunit ABC10-beta genetic 1 1 1 Positive Genetic
PPH21 YDL134C Catalytic subunit of protein phosphatase 2A, PP2A genetic 1 1 1 Negative Genetic
ANP1 YEL036C Subunit of the alpha-1,6 mannosyltransferase complex genetic 1 1 1 Negative Genetic
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 1 1 1 Negative Genetic
GAL83 YER027C One of three alternate beta-subunits of the Snf1 kinase complex genetic 1 1 1 Synthetic Growth Defect
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex genetic 1 1 1 Negative Genetic
SPC110 YDR356W Inner plaque spindle pole body (SPB) component physical 1 1 1 Affinity Capture-MS
SPC42 YKL042W Central plaque component of spindle pole body (SPB) physical 1 1 1 Affinity Capture-MS
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family physical 1 1 1 Affinity Capture-MS
SSA2 YLL024C HSP70 family ATP-binding protein physical 1 1 1 Affinity Capture-MS
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 1 1 1 Affinity Capture-MS
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
SIP2 YGL208W One of three alternate beta subunits of the Snf1 kinase complex physical 1 1 1 Biochemical Activity
SIP2 YGL208W One of three alternate beta subunits of the Snf1 kinase complex genetic 1 1 1 Synthetic Growth Defect
WWM1 YFL010C WW domain containing protein of unknown function genetic 1 1 1 Positive Genetic
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 1 1 1 Phenotypic Suppression
SKY1 YMR216C SR protein kinase (SRPK) genetic 1 1 1 Negative Genetic
SPT2 YER161C Protein involved in negative regulation of transcription genetic 1 1 1 Negative Genetic
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 1 1 1 Negative Genetic
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) genetic 1 1 1 Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Negative Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Negative Genetic
TAO3 YIL129C Component of the RAM signaling network genetic 1 1 1 Positive Genetic
STP22 YCL008C Component of the ESCRT-I complex genetic 1 1 1 Positive Genetic
YJR084W YJR084W Protein that forms a complex with Thp3p genetic 1 1 1 Positive Genetic
SSC1 YJR045C Hsp70 family ATPase genetic 1 1 1 Negative Genetic
SCO1 YBR037C Copper-binding protein of mitochondrial inner membrane genetic 1 1 1 Negative Genetic
SNT1 YCR033W Set3C histone deacetylase scaffold genetic 1 1 1 Negative Genetic
THR4 YCR053W Threonine synthase genetic 1 1 1 Negative Genetic
YDR239C YDR239C Protein of unknown function genetic 1 1 1 Negative Genetic
YLR415C YLR415C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YNL134C YNL134C NADH-dependent aldehyde reductase genetic 1 1 1 Negative Genetic
YGL235W YGL235W Putative protein of unknown function genetic 1 1 1 Negative Genetic
TIM21 YGR033C Nonessential component of the TIM23 complex genetic 1 1 1 Negative Genetic
YHR050W-A YHR050W-A Protein of unknown function genetic 1 1 1 Negative Genetic
SET3 YKR029C Defining member of the SET3 histone deacetylase complex genetic 1 1 1 Negative Genetic
YML053C YML053C Putative protein of unknown function genetic 1 1 1 Negative Genetic
SSO2 YMR183C Plasma membrane t-SNARE genetic 1 1 1 Negative Genetic
TUF1 YOR187W Mitochondrial translation elongation factor Tu (EF-Tu) genetic 1 1 1 Negative Genetic
SUV3 YPL029W ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
YPL039W YPL039W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Positive Genetic
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting genetic 1 1 1 Negative Genetic
TOP3 YLR234W DNA Topoisomerase III genetic 1 1 1 Negative Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Negative Genetic
SPE2 YOL052C S-adenosylmethionine decarboxylase genetic 1 1 1 Positive Genetic
SPE1 YKL184W Ornithine decarboxylase genetic 1 1 1 Positive Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Negative Genetic
RSM7 YJR113C Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Negative Genetic
GSF2 YML048W Endoplasmic reticulum (ER) localized integral membrane protein genetic 1 1 1 Negative Genetic
POR1 YNL055C Mitochondrial porin (voltage-dependent anion channel) genetic 1 1 1 Negative Genetic
COF1 YLL050C Cofilin, involved in pH-dependent actin filament depolarization genetic 1 1 1 Negative Genetic
CDC60 YPL160W Cytosolic leucyl tRNA synthetase genetic 1 1 1 Positive Genetic
RVS167 YDR388W Calmodulin-binding actin-associated protein physical 1 1 1 Affinity Capture-MS
HHO1 YPL127C Histone H1, linker histone with roles in meiosis and sporulation genetic 1 1 1 Synthetic Rescue
LHS1 YKL073W Molecular chaperone of the endoplasmic reticulum lumen genetic 1 1 1 Positive Genetic
OPY1 YBR129C Protein of unknown function genetic 1 1 1 Negative Genetic
OMS1 YDR316W Protein integral to the mitochondrial membrane genetic 1 1 1 Negative Genetic
PTC2 YER089C Type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
MIG1 YGL035C Transcription factor involved in glucose repression physical 1 1 1 Biochemical Activity
PRS2 YER099C 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase genetic 1 1 1 Negative Genetic
MDH3 YDL078C Peroxisomal malate dehydrogenase genetic 1 1 1 Negative Genetic
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Negative Genetic
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis genetic 1 1 1 Positive Genetic
NDL1 YLR254C Homolog of nuclear distribution factor NudE genetic 1 1 1 Positive Genetic
COQ5 YML110C 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase genetic 1 1 1 Negative Genetic
GRC3 YLL035W Polynucleotide kinase present on rDNA genetic 1 1 1 Positive Genetic
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 1 1 1 Negative Genetic
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Negative Genetic
IES3 YLR052W Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Positive Genetic
CLC1 YGR167W Clathrin light chain genetic 1 1 1 Negative Genetic
ELO2 YCR034W Fatty acid elongase, involved in sphingolipid biosynthesis genetic 1 1 1 Negative Genetic
OST3 YOR085W Gamma subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Positive Genetic
CNM67 YNL225C Component of the spindle pole body outer plaque physical 1 1 1 Affinity Capture-MS
PCL1 YNL289W Cyclin, interacts with cyclin-dependent kinase Pho85p genetic 1 1 1 Negative Genetic
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Phenotypic Suppression
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Negative Genetic
PFY1 YOR122C Profilin genetic 1 1 1 Negative Genetic
COX17 YLL009C Copper metallochaperone that transfers copper to Sco1p and Cox11p genetic 1 1 1 Negative Genetic
ERF2 YLR246W Subunit of a palmitoyltransferase genetic 1 1 1 Dosage Growth Defect
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Negative Genetic
MRPL17 YNL252C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MSS1 YMR023C Mitochondrial protein genetic 1 1 1 Negative Genetic
NAM2 YLR382C Mitochondrial leucyl-tRNA synthetase genetic 1 1 1 Negative Genetic
MSF1 YPR047W Mitochondrial phenylalanyl-tRNA synthetase genetic 1 1 1 Negative Genetic
MRPL32 YCR003W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
ABZ2 YMR289W Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase) genetic 1 1 1 Negative Genetic
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 1 1 1 Negative Genetic
MRPL27 YBR282W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MTG2 YHR168W Putative GTPase genetic 1 1 1 Negative Genetic
MTM1 YGR257C Mitochondrial protein of the mitochondrial carrier family genetic 1 1 1 Negative Genetic
ILM1 YJR118C Protein of unknown function genetic 1 1 1 Negative Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Negative Genetic
MET5 YJR137C Sulfite reductase beta subunit genetic 1 1 1 Negative Genetic
FMC1 YIL098C Mitochondrial matrix protein genetic 1 1 1 Negative Genetic
MDL2 YPL270W Mitochondrial inner membrane half-type ABC transporter genetic 1 1 1 Negative Genetic
IZH2 YOL002C Plasma membrane receptor for plant antifungal osmotin genetic 1 1 1 Synthetic Growth Defect
COX16 YJL003W Mitochondrial inner membrane protein genetic 1 1 1 Negative Genetic
AGP1 YCL025C Broad-specificity, low-affinity amino acid permease genetic 1 1 1 Negative Genetic
PHO3 YBR092C Constitutively expressed acid phosphatase similar to Pho5p genetic 1 1 1 Positive Genetic
ATP23 YNR020C Putative metalloprotease of the mitochondrial inner membrane genetic 1 1 1 Negative Genetic
ICT1 YLR099C Lysophosphatidic acid acyltransferase genetic 1 1 1 Negative Genetic
RDL2 YOR286W Protein with rhodanese activity genetic 1 1 1 Negative Genetic
OCA6 YDR067C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Negative Genetic