Standard name Systematic name Name description Description
SNF1 YDR477W AMP-activated S/T protein kinase AMP-activated S/T protein kinase; complexes with Snf4p and a Sip1p/Sip2p/Gal83p family member; required for glucose-repressed gene transcription, heat shock, sporulation, and peroxisome biogenesis; active form involved in mitotic spindle alignment in non-limiting glucose; regulates Hxk2p nucleocytoplasmic shuttling; regulates filamentous growth and acts as a non-canonical GEF-activating Arf3p during invasive growth; sumoylation inhibits Snf1p, targeting it for Ub-ligase mediated destruction
Visualize the interactome of SNF1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.992 0.976 1.000
Cell Periphery NaN NaN 0.062

GFP localization & abundance

GFP localization GFP abundance
cytoplasm 589

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SNF1 11 3 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex physical 54 7 50 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Two-hybrid, Co-crystal Structure, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Co-localization, Two-hybrid
MIG1 YGL035C Transcription factor involved in glucose repression genetic 17 4 15 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Dosage Growth Defect, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement
SIP2 YGL208W One of three alternate beta subunits of the Snf1 kinase complex physical 16 5 14 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Biochemical Activity, Two-hybrid, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex
GAL83 YER027C One of three alternate beta-subunits of the Snf1 kinase complex physical 14 4 14 Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western
REG1 YDR028C Regulatory subunit of type 1 protein phosphatase Glc7p genetic 14 3 12 Synthetic Rescue, Phenotypic Suppression, Positive Genetic, Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue
SAK1 YER129W Upstream serine/threonine kinase for the SNF1 complex physical 14 4 8 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Biochemical Activity, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Affinity Capture-Western, Affinity Capture-Western, Biochemical Activity
MIG1 YGL035C Transcription factor involved in glucose repression physical 13 3 12 Affinity Capture-Western, Two-hybrid, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Affinity Capture-Western, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity
REG1 YDR028C Regulatory subunit of type 1 protein phosphatase Glc7p physical 13 4 11 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, PCA, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western
SIP1 YDR422C One of three alternate beta-subunits of the Snf1p kinase complex physical 13 4 11 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-MS, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex genetic 7 4 7 Dosage Rescue, Dosage Rescue, Synthetic Rescue, Phenotypic Enhancement, Positive Genetic, Phenotypic Enhancement, Positive Genetic
GET1 YGL020C Subunit of the GET complex genetic 6 2 6 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 6 2 5 Positive Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 6 1 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SIT4 YDL047W Ceramide-activated, type 2A-related serine-threonine phosphatase genetic 6 4 3 Synthetic Rescue, Positive Genetic, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Suppression
SIP4 YJL089W C6 zinc cluster transcriptional activator physical 6 2 3 Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 5 1 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
MSN2 YMR037C Stress-responsive transcriptional activator genetic 5 4 4 Dosage Rescue, Negative Genetic, Synthetic Growth Defect, Dosage Rescue, Phenotypic Enhancement
ACC1 YNR016C Acetyl-CoA carboxylase, biotin containing enzyme genetic 5 3 4 Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Phenotypic Enhancement
HXK2 YGL253W Hexokinase isoenzyme 2 physical 5 3 4 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex
PDE2 YOR360C High-affinity cyclic AMP phosphodiesterase genetic 5 3 4 Dosage Rescue, Dosage Rescue, Synthetic Growth Defect, Dosage Rescue, Negative Genetic
GSF2 YML048W Endoplasmic reticulum (ER) localized integral membrane protein genetic 5 2 4 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
IRE1 YHR079C Serine-threonine kinase and endoribonuclease genetic 5 2 4 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SNF1 YDR477W AMP-activated S/T protein kinase physical 5 4 3 Co-crystal Structure, Reconstituted Complex, Affinity Capture-Western, Biochemical Activity, Biochemical Activity
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 5 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
HXK2 YGL253W Hexokinase isoenzyme 2 genetic 5 2 3 Negative Genetic, Synthetic Rescue, Synthetic Rescue, Negative Genetic, Negative Genetic
STD1 YOR047C Protein involved in control of glucose-regulated gene expression physical 5 2 2 Reconstituted Complex, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid
ADR1 YDR216W Carbon source-responsive zinc-finger transcription factor genetic 4 3 4 Synthetic Rescue, Synthetic Rescue, Dosage Rescue, Phenotypic Suppression
SLX9 YGR081C Protein required for pre-rRNA processing genetic 4 2 4 Positive Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GET2 YER083C Subunit of the GET complex genetic 4 2 4 Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic
ARO1 YDR127W Pentafunctional arom protein genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ELP2 YGR200C Subunit of Elongator complex genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SNT1 YCR033W Set3C histone deacetylase scaffold genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CNB1 YKL190W Calcineurin B genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
NRG1 YDR043C Transcriptional repressor genetic 4 1 4 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue
ATG21 YPL100W Phosphoinositide binding protein genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SSN3 YPL042C Component of the RNA polymerase II mediator complex physical 4 3 3 Affinity Capture-Western, Two-hybrid, Biochemical Activity, Affinity Capture-Western
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 4 3 3 Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement
GPT2 YKR067W Glycerol-3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SUR2 YDR297W Sphinganine C4-hydroxylase genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
DUF1 YOL087C Ubiquitin-binding protein of unknown function genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
FAT1 YBR041W Very long chain fatty acyl-CoA synthetase and fatty acid transporter genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
MET22 YOL064C Bisphosphate-3'-nucleotidase genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SWI6 YLR182W Transcription cofactor physical 4 1 2 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
CYR1 YJL005W Adenylate cyclase physical 4 3 1 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Biochemical Activity
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase genetic 3 3 3 Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
ROX3 YBL093C Subunit of the RNA polymerase II mediator complex genetic 3 3 3 Dosage Rescue, Synthetic Rescue, Negative Genetic
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 3 3 3 Phenotypic Enhancement, Synthetic Rescue, Negative Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 3 3 3 Phenotypic Suppression, Negative Genetic, Synthetic Growth Defect
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit physical 3 2 3 Affinity Capture-MS, Biochemical Activity, Biochemical Activity
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 3 2 3 Synthetic Rescue, Negative Genetic, Negative Genetic
TPS1 YBR126C Synthase subunit of trehalose-6-P synthase/phosphatase complex genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Rescue
PHO85 YPL031C Cyclin-dependent kinase genetic 3 2 3 Synthetic Lethality, Synthetic Rescue, Synthetic Rescue
ROD1 YOR018W Alpha-arrestin involved in ubiquitin-dependent endocytosis physical 3 2 3 Biochemical Activity, Two-hybrid, Biochemical Activity
RDS2 YPL133C Transcription factor involved in regulating gluconeogenesis physical 3 2 3 Biochemical Activity, Biochemical Activity, Reconstituted Complex
ADH1 YOL086C Alcohol dehydrogenase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
YPT6 YLR262C Rab family GTPase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
UBP13 YBL067C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SWF1 YDR126W Palmitoyltransferase that acts on transmembrane proteins genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
FYV10 YIL097W Subunit of GID complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ACS1 YAL054C Acetyl-coA synthetase isoform genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
AMD1 YML035C AMP deaminase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RPL43A YPR043W Ribosomal 60S subunit protein L43A genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ARO7 YPR060C Chorismate mutase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
MRN1 YPL184C RNA-binding protein that may be involved in translational regulation genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PAU17 YLL025W Protein of unknown function genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 3 3 2 Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme physical 3 3 2 Affinity Capture-Western, Two-hybrid, PCA
GIS4 YML006C CAAX box containing protein of unknown function genetic 3 3 2 Dosage Rescue, Synthetic Growth Defect, Negative Genetic
GAL4 YPL248C DNA-binding transcription factor required for activating GAL genes physical 3 3 2 Reconstituted Complex, Affinity Capture-Western, Co-localization
MIG3 YER028C Transcriptional regulator genetic 3 3 2 Dosage Lethality, Synthetic Rescue, Dosage Growth Defect
MIG1 YGL035C Transcription factor involved in glucose repression regulation 3 2 2 green fluorescent protein fusion protein localization evidence, green fluorescent protein fusion protein localization evidence, qualitative western immunoblotting evidence
ROD1 YOR018W Alpha-arrestin involved in ubiquitin-dependent endocytosis genetic 3 2 2 Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue
SIP5 YMR140W Protein of unknown function physical 3 2 2 Affinity Capture-Western, Two-hybrid, Two-hybrid
HSF1 YGL073W Trimeric heat shock transcription factor physical 3 2 2 Two-hybrid, Biochemical Activity, Biochemical Activity
ILM1 YJR118C Protein of unknown function genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system physical 3 3 1 Affinity Capture-Western, Two-hybrid, Biochemical Activity
ARF3 YOR094W Glucose-repressible ADP-ribosylation factor physical 3 3 1 Affinity Capture-Western, Two-hybrid, Reconstituted Complex
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex physical 3 2 1 Affinity Capture-Western, Affinity Capture-Western, Biochemical Activity
POR1 YNL055C Mitochondrial porin (voltage-dependent anion channel) physical 3 2 1 Two-hybrid, Two-hybrid, Affinity Capture-Western
REG2 YBR050C Regulatory subunit of the Glc7p type-1 protein phosphatase physical 3 2 1 Two-hybrid, Two-hybrid, Affinity Capture-Western
BMH1 YER177W 14-3-3 protein, major isoform physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 2 2 2 Phenotypic Enhancement, Synthetic Rescue
PGD1 YGL025C Subunit of the RNA polymerase II mediator complex genetic 2 2 2 Negative Genetic, Synthetic Lethality
SIP1 YDR422C One of three alternate beta-subunits of the Snf1p kinase complex genetic 2 2 2 Dosage Rescue, Negative Genetic
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 2 2 2 Synthetic Rescue, Positive Genetic
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 2 2 2 Synthetic Rescue, Positive Genetic
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 2 2 2 Affinity Capture-MS, Co-purification
YHR214C-C YHR214C-C Retrotransposon TYA Gag gene co-transcribed with TYB Pol physical 2 2 2 Biochemical Activity, Reconstituted Complex
TEF2 YBR118W Translational elongation factor EF-1 alpha physical 2 2 2 Biochemical Activity, Affinity Capture-MS
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex genetic 2 2 2 Dosage Rescue, Synthetic Rescue
TUP1 YCR084C General repressor of transcription in complex with Cyc8p genetic 2 2 2 Synthetic Rescue, Phenotypic Suppression
SCP160 YJL080C Essential RNA-binding G protein effector of mating response pathway physical 2 2 2 Biochemical Activity, Reconstituted Complex
POR1 YNL055C Mitochondrial porin (voltage-dependent anion channel) genetic 2 2 2 Negative Genetic, Synthetic Rescue
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation genetic 2 2 2 Phenotypic Enhancement, Synthetic Rescue
GIS4 YML006C CAAX box containing protein of unknown function physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
SIS1 YNL007C Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p physical 2 2 2 Biochemical Activity, Reconstituted Complex
ATG1 YGL180W Protein serine/threonine kinase genetic 2 2 2 Dosage Rescue, Positive Genetic
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 2 2 2 Negative Genetic, Phenotypic Enhancement
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 2 2 2 Positive Genetic, Negative Genetic
CSE4 YKL049C Centromeric histone H3-like protein physical 2 2 2 Affinity Capture-MS, Two-hybrid
GAL80 YML051W Transcriptional regulator involved in the repression of GAL genes genetic 2 2 2 Synthetic Rescue, Dosage Growth Defect
HAC1 YFL031W Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) genetic 2 2 2 Synthetic Rescue, Negative Genetic
ROG3 YFR022W Alpha-arrestin involved in ubiquitin-dependent endocytosis physical 2 2 2 Biochemical Activity, Two-hybrid
MIG2 YGL209W Zinc finger transcriptional repressor physical 2 2 2 Biochemical Activity, Affinity Capture-Western
RPL8A YHL033C Ribosomal 60S subunit protein L8A physical 2 2 2 Biochemical Activity, Affinity Capture-MS
MSN4 YKL062W Stress-responsive transcriptional activator genetic 2 2 2 Synthetic Growth Defect, Phenotypic Enhancement
NSG1 YHR133C Protein involved in regulation of sterol biosynthesis physical 2 2 2 Biochemical Activity, Reconstituted Complex
HXT1 YHR094C Low-affinity glucose transporter of the major facilitator superfamily genetic 2 2 2 Dosage Rescue, Negative Genetic
SLG1 YOR008C Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
ENA1 YDR040C P-type ATPase sodium pump genetic 2 2 2 Synthetic Rescue, Dosage Rescue
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 2 2 2 Negative Genetic, Positive Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 2 1 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence
SAP155 YFR040W Protein required for function of the Sit4p protein phosphatase genetic 2 1 2 Positive Genetic, Positive Genetic
LRP1 YHR081W Nuclear exosome-associated nucleic acid binding protein genetic 2 1 2 Negative Genetic, Negative Genetic
BDF1 YLR399C BET family transcriptional regulator genetic 2 1 2 Negative Genetic, Negative Genetic
GLO3 YER122C ADP-ribosylation factor GTPase activating protein (ARF GAP) physical 2 1 2 Biochemical Activity, Biochemical Activity
HRR25 YPL204W Conserved casein kinase, monopolin subunit genetic 2 1 2 Negative Genetic, Negative Genetic
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 2 1 2 Negative Genetic, Negative Genetic
UBI4 YLL039C Ubiquitin physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 2 1 2 Negative Genetic, Negative Genetic
YMD8 YML038C Putative nucleotide sugar transporter genetic 2 1 2 Negative Genetic, Negative Genetic
VPS17 YOR132W Subunit of the membrane-associated retromer complex genetic 2 1 2 Negative Genetic, Negative Genetic
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 2 1 2 Negative Genetic, Negative Genetic
SWH1 YAR042W Protein similar to mammalian oxysterol-binding protein genetic 2 1 2 Negative Genetic, Negative Genetic
ADO1 YJR105W Adenosine kinase genetic 2 1 2 Negative Genetic, Negative Genetic
CHK1 YBR274W Serine/threonine kinase and DNA damage checkpoint effector genetic 2 1 2 Positive Genetic, Positive Genetic
RGP1 YDR137W Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) genetic 2 1 2 Negative Genetic, Negative Genetic
CYC8 YBR112C General transcriptional co-repressor genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
KSS1 YGR040W Mitogen-activated protein kinase (MAPK) genetic 2 1 2 Negative Genetic, Negative Genetic
RIM11 YMR139W Protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 1 2 Negative Genetic, Negative Genetic
KKQ8 YKL168C Putative serine/threonine protein kinase with unknown cellular role genetic 2 1 2 Negative Genetic, Negative Genetic
MMR1 YLR190W Phosphorylated protein of the mitochondrial outer membrane genetic 2 1 2 Negative Genetic, Negative Genetic
PPA2 YMR267W Mitochondrial inorganic pyrophosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
COG5 YNL051W Component of the conserved oligomeric Golgi complex genetic 2 1 2 Negative Genetic, Negative Genetic
RGT1 YKL038W Glucose-responsive transcription factor genetic 2 1 2 Negative Genetic, Negative Genetic
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 2 1 2 Positive Genetic, Positive Genetic
NRG2 YBR066C Transcriptional repressor genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
GYP1 YOR070C Cis-golgi GTPase-activating protein (GAP) for yeast Rabs genetic 2 1 2 Negative Genetic, Negative Genetic
CAT8 YMR280C Zinc cluster transcriptional activator genetic 2 1 2 Dosage Rescue, Dosage Rescue
FBP26 YJL155C Fructose-2,6-bisphosphatase, required for glucose metabolism genetic 2 1 2 Negative Genetic, Negative Genetic
SIP3 YNL257C Putative sterol transfer protein physical 2 1 2 Two-hybrid, Two-hybrid
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
AIM44 YPL158C Regulator of Cdc42p and Rho1p genetic 2 1 2 Negative Genetic, Negative Genetic
MIG2 YGL209W Zinc finger transcriptional repressor genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
MRS2 YOR334W Mitochondrial inner membrane Mg(2+) channel genetic 2 1 2 Negative Genetic, Negative Genetic
RPP2A YOL039W Ribosomal protein P2 alpha genetic 2 1 2 Negative Genetic, Negative Genetic
SCH9 YHR205W AGC family protein kinase physical 2 1 2 Biochemical Activity, Biochemical Activity
MDM38 YOL027C Membrane-associated mitochondrial ribosome receptor genetic 2 1 2 Negative Genetic, Negative Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 2 1 2 Negative Genetic, Negative Genetic
PSD1 YNL169C Phosphatidylserine decarboxylase of the mitochondrial inner membrane genetic 2 1 2 Negative Genetic, Negative Genetic
SEI1 YLR404W Seipin involved in lipid droplet (LD) assembly genetic 2 1 2 Negative Genetic, Negative Genetic
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex regulation 2 2 1 protein kinase assay evidence, qualitative western immunoblotting evidence
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex physical 2 2 1 Affinity Capture-Western, Two-hybrid
BAT1 YHR208W Mitochondrial branched-chain amino acid (BCAA) aminotransferase genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
CDC14 YFR028C Protein phosphatase required for mitotic exit physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) physical 2 2 1 Two-hybrid, Affinity Capture-Western
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
SWM2 YNR004W Protein with a role in snRNA and snoRNA cap trimethylation physical 2 2 1 Reconstituted Complex, Affinity Capture-Western
YBR096W YBR096W Putative protein of unknown function physical 2 2 1 Reconstituted Complex, Affinity Capture-Western
TOR1 YJR066W PIK-related protein kinase and rapamycin target genetic 2 2 1 Phenotypic Enhancement, Phenotypic Suppression
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 2 2 1 Synthetic Growth Defect, Phenotypic Suppression
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes physical 2 2 1 Biochemical Activity, Reconstituted Complex
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 2 2 1 Synthetic Growth Defect, Phenotypic Suppression
HYP2 YEL034W Translation elongation factor eIF-5A genetic 2 2 1 Positive Genetic, Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 2 2 1 Positive Genetic, Negative Genetic
NRG2 YBR066C Transcriptional repressor physical 2 2 1 Affinity Capture-Western, Two-hybrid
BAT2 YJR148W Cytosolic branched-chain amino acid (BCAA) aminotransferase genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
MRC1 YCL061C S-phase checkpoint protein required for DNA replication physical 2 2 1 Biochemical Activity, Affinity Capture-Western
ROG3 YFR022W Alpha-arrestin involved in ubiquitin-dependent endocytosis genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
NPR1 YNL183C Protein kinase physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RRP1 YDR087C Essential evolutionarily conserved nucleolar protein genetic 2 1 1 Negative Genetic, Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 1 1 Negative Genetic, Negative Genetic
SEC62 YPL094C Essential subunit of Sec63 complex genetic 2 1 1 Negative Genetic, Negative Genetic
YAP5 YIR018W Basic leucine zipper (bZIP) iron-sensing transcription factor genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
SEC53 YFL045C Phosphomannomutase genetic 2 1 1 Negative Genetic, Negative Genetic
ATG5 YPL149W Conserved protein involved in autophagy and the Cvt pathway genetic 2 1 1 Negative Genetic, Negative Genetic
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 2 1 1 Negative Genetic, Negative Genetic
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 DNA to cDNA expression microarray evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SCH9 YHR205W AGC family protein kinase regulation 1 1 1 qualitative western immunoblotting evidence
EAP1 YKL204W eIF4E-associated protein, competes with eIF4G for binding to eIF4E regulation 1 1 1 qualitative western immunoblotting evidence
MAF1 YDR005C Highly conserved negative regulator of RNA polymerase III regulation 1 1 1 qualitative western immunoblotting evidence
PAB1 YER165W Poly(A) binding protein regulation 1 1 1 qualitative western immunoblotting evidence
PUB1 YNL016W Poly (A)+ RNA-binding protein regulation 1 1 1 qualitative western immunoblotting evidence
GCN2 YDR283C Protein kinase regulation 1 1 1 qualitative western immunoblotting evidence
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation regulation 1 1 1 qualitative western immunoblotting evidence
NAB6 YML117W Putative RNA-binding protein regulation 1 1 1 qualitative western immunoblotting evidence
SLF1 YDR515W RNA binding protein that associates with polysomes regulation 1 1 1 qualitative western immunoblotting evidence
KSP1 YHR082C Serine/threonine protein kinase regulation 1 1 1 qualitative western immunoblotting evidence
BRE5 YNR051C Ubiquitin protease cofactor regulation 1 1 1 qualitative western immunoblotting evidence
SAK1 YER129W Upstream serine/threonine kinase for the SNF1 complex regulation 1 1 1 enzymatic activity assay evidence
CWC25 YNL245C Splicing factor required for the first step of pre-mRNA splicing genetic 1 1 1 Negative Genetic
GWT1 YJL091C Protein involved in the inositol acylation of GlcN-PI genetic 1 1 1 Negative Genetic
LEO1 YOR123C Component of the Paf1 complex physical 1 1 1 Biochemical Activity
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) genetic 1 1 1 Negative Genetic
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex genetic 1 1 1 Phenotypic Suppression
SDS22 YKL193C Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p physical 1 1 1 Affinity Capture-MS
HSP60 YLR259C Tetradecameric mitochondrial chaperonin genetic 1 1 1 Negative Genetic
HAS1 YMR290C ATP-dependent RNA helicase physical 1 1 1 Biochemical Activity
NOG1 YPL093W Putative GTPase genetic 1 1 1 Negative Genetic
HOL1 YNR055C Putative transporter in the major facilitator superfamily genetic 1 1 1 Negative Genetic
PFK27 YOL136C 6-phosphofructo-2-kinase physical 1 1 1 Biochemical Activity
PFK27 YOL136C 6-phosphofructo-2-kinase genetic 1 1 1 Dosage Growth Defect
POP1 YNL221C Subunit of RNase MRP, nuclear RNase P and telomerase complexes genetic 1 1 1 Negative Genetic
PRP45 YAL032C Protein required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
NTR2 YKR022C Essential protein that forms a dimer with Ntr1p physical 1 1 1 Biochemical Activity
NOC3 YLR002C Subunit of a nuclear complex with Noc2p and pre-replicative complexes genetic 1 1 1 Negative Genetic
POL5 YEL055C Protein involved in 60S assembly and pre-40S AFs recycling genetic 1 1 1 Negative Genetic
HCA4 YJL033W DEAD box RNA helicase physical 1 1 1 Biochemical Activity
RCK2 YLR248W Protein kinase involved in response to oxidative and osmotic stress genetic 1 1 1 Dosage Rescue
SIT4 YDL047W Ceramide-activated, type 2A-related serine-threonine phosphatase physical 1 1 1 Affinity Capture-Western
LSM1 YJL124C Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
LSM3 YLR438C-A Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 1 1 1 Negative Genetic
RRP43 YCR035C Exosome non-catalytic core component physical 1 1 1 Affinity Capture-MS
RRP6 YOR001W Nuclear exosome exonuclease component genetic 1 1 1 Negative Genetic
RPA34 YJL148W RNA polymerase I subunit A34.5 physical 1 1 1 Biochemical Activity
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
RPA190 YOR341W RNA polymerase I largest subunit A190 genetic 1 1 1 Negative Genetic
RPA43 YOR340C RNA polymerase I subunit A43 physical 1 1 1 Biochemical Activity
RPL3 YOR063W Ribosomal 60S subunit protein L3 physical 1 1 1 Affinity Capture-MS
MFT1 YML062C Subunit of the THO complex physical 1 1 1 Biochemical Activity
GCD11 YER025W Gamma subunit of the translation initiation factor eIF2 genetic 1 1 1 Negative Genetic
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Lethality
DST1 YGL043W General transcription elongation factor TFIIS physical 1 1 1 Reconstituted Complex
DST1 YGL043W General transcription elongation factor TFIIS genetic 1 1 1 Negative Genetic
PWP1 YLR196W Protein with WD-40 repeats involved in rRNA processing genetic 1 1 1 Negative Genetic
REI1 YBR267W Cytoplasmic pre-60S factor genetic 1 1 1 Negative Genetic
RPN2 YIL075C Subunit of the 26S proteasome physical 1 1 1 Biochemical Activity
HCR1 YLR192C eIF3j component of translation initiation factor 3 (eIF3) physical 1 1 1 Biochemical Activity
HCR1 YLR192C eIF3j component of translation initiation factor 3 (eIF3) genetic 1 1 1 Negative Genetic
NIP1 YMR309C eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Affinity Capture-MS
CFT1 YDR301W RNA-binding subunit of the mRNA cleavage and polyadenylation factor physical 1 1 1 Affinity Capture-MS
IMD2 YHR216W Inosine monophosphate dehydrogenase physical 1 1 1 Affinity Capture-MS
IMD3 YLR432W Inosine monophosphate dehydrogenase physical 1 1 1 Affinity Capture-MS
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex genetic 1 1 1 Negative Genetic
NUP82 YJL061W Linker nucleoporin component of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
LHP1 YDL051W RNA binding protein required for maturation of tRNA and U6 snRNA physical 1 1 1 Biochemical Activity
EFT2 YDR385W Elongation factor 2 (EF-2), also encoded by EFT1 physical 1 1 1 Affinity Capture-MS
APC1 YNL172W Largest subunit of the Anaphase-Promoting Complex/Cyclosome genetic 1 1 1 Positive Genetic
ATG14 YBR128C Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I genetic 1 1 1 Negative Genetic
ARC15 YIL062C Subunit of the ARP2/3 complex genetic 1 1 1 Negative Genetic
ARC18 YLR370C Subunit of the ARP2/3 complex genetic 1 1 1 Negative Genetic
ARC35 YNR035C Subunit of the ARP2/3 complex genetic 1 1 1 Negative Genetic
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 1 1 1 Negative Genetic
BMH2 YDR099W 14-3-3 protein, minor isoform physical 1 1 1 Affinity Capture-MS
BUD14 YAR014C Protein involved in bud-site selection physical 1 1 1 Biochemical Activity
BUD14 YAR014C Protein involved in bud-site selection genetic 1 1 1 Negative Genetic
CAP1 YKL007W Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p) genetic 1 1 1 Negative Genetic
CDC14 YFR028C Protein phosphatase required for mitotic exit genetic 1 1 1 Phenotypic Suppression
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 1 1 1 Negative Genetic
CDC12 YHR107C Component of the septin ring that is required for cytokinesis physical 1 1 1 Co-localization
CDC3 YLR314C Component of the septin ring that is required for cytokinesis physical 1 1 1 Co-localization
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 1 1 1 Negative Genetic
NOG2 YNR053C Putative GTPase genetic 1 1 1 Negative Genetic
AVO1 YOL078W Component of the membrane-bound TORC2 complex genetic 1 1 1 Negative Genetic
CNS1 YBR155W TPR-containing co-chaperone physical 1 1 1 Biochemical Activity
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex physical 1 1 1 Affinity Capture-MS
COX4 YGL187C Subunit IV of cytochrome c oxidase genetic 1 1 1 Negative Genetic
COX6 YHR051W Subunit VI of cytochrome c oxidase (Complex IV) genetic 1 1 1 Negative Genetic
CYS4 YGR155W Cystathionine beta-synthase genetic 1 1 1 Negative Genetic
EDE1 YBL047C Scaffold protein involved in the formation of early endocytic sites genetic 1 1 1 Negative Genetic
EMG1 YLR186W Methyltransferase for rRNA genetic 1 1 1 Negative Genetic
FIP1 YJR093C Subunit of cleavage polyadenylation factor (CPF) genetic 1 1 1 Negative Genetic
GCN2 YDR283C Protein kinase physical 1 1 1 Affinity Capture-Western
GCD7 YLR291C Beta subunit of translation initiation factor eIF2B genetic 1 1 1 Negative Genetic
BDF2 YDL070W Protein involved in transcription initiation physical 1 1 1 Biochemical Activity
DYN1 YKR054C Cytoplasmic heavy chain dynein genetic 1 1 1 Phenotypic Enhancement
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
COG8 YML071C Component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
KIN3 YAR018C Nonessential serine/threonine protein kinase genetic 1 1 1 Negative Genetic
END3 YNL084C EH domain-containing protein involved in endocytosis genetic 1 1 1 Negative Genetic
LAS17 YOR181W Actin assembly factor genetic 1 1 1 Negative Genetic
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
ENO2 YHR174W Enolase II, a phosphopyruvate hydratase physical 1 1 1 Affinity Capture-MS
MAK10 YEL053C Non-catalytic subunit of the NatC N-terminal acetyltransferase genetic 1 1 1 Negative Genetic
MAK3 YPR051W Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT) genetic 1 1 1 Negative Genetic
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Rescue
MED2 YDL005C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
MED6 YHR058C Subunit of the RNA polymerase II mediator complex physical 1 1 1 PCA
MRPL4 YLR439W Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Biochemical Activity
GEP3 YOR205C Protein required for mitochondrial ribosome small subunit biogenesis genetic 1 1 1 Negative Genetic
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member physical 1 1 1 Biochemical Activity
MGM101 YJR144W Protein with a role in mitochondrial DNA recombinational repair genetic 1 1 1 Negative Genetic
ATG3 YNR007C E2-like enzyme genetic 1 1 1 Negative Genetic
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 1 1 1 Negative Genetic
HTZ1 YOL012C Histone variant H2AZ genetic 1 1 1 Negative Genetic
ITC1 YGL133W Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex genetic 1 1 1 Negative Genetic
FAS2 YPL231W Alpha subunit of fatty acid synthetase physical 1 1 1 Affinity Capture-MS
MGS1 YNL218W Protein with DNA-dependent ATPase and ssDNA annealing activities physical 1 1 1 Two-hybrid
DOA4 YDR069C Ubiquitin hydrolase genetic 1 1 1 Negative Genetic
LAT1 YNL071W Dihydrolipoamide acetyltransferase component (E2) of the PDC genetic 1 1 1 Negative Genetic
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase physical 1 1 1 Affinity Capture-MS
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-MS
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Lethality
LEA1 YPL213W Component of U2 snRNP complex genetic 1 1 1 Negative Genetic
DAM1 YGR113W Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 1 1 1 Negative Genetic
MDS3 YGL197W Putative component of the TOR regulatory pathway genetic 1 1 1 Positive Genetic
PDC1 YLR044C Major of three pyruvate decarboxylase isozymes physical 1 1 1 Affinity Capture-MS
RAD23 YEL037C Protein with ubiquitin-like N terminus genetic 1 1 1 Synthetic Growth Defect
MET18 YIL128W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Negative Genetic
CPA2 YJR109C Large subunit of carbamoyl phosphate synthetase physical 1 1 1 Affinity Capture-MS
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Negative Genetic
REF2 YDR195W RNA-binding protein genetic 1 1 1 Negative Genetic
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
RNA14 YMR061W Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Synthetic Growth Defect
MRPL6 YHR147C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
NUT2 YPR168W Subunit of the RNA polymerase II mediator complex physical 1 1 1 PCA
RPB11 YOL005C RNA polymerase II subunit B12.5 genetic 1 1 1 Negative Genetic
IWR1 YDL115C RNA polymerase II transport factor, conserved from yeast to humans genetic 1 1 1 Negative Genetic
RPL23A YBL087C Ribosomal 60S subunit protein L23A physical 1 1 1 Affinity Capture-MS
OPI1 YHL020C Transcriptional regulator of a variety of genes genetic 1 1 1 Negative Genetic
RSA4 YCR072C Ribosomal large subunit (60S) assembly factor physical 1 1 1 Reconstituted Complex
REA1 YLR106C Huge dynein-related AAA-type ATPase (midasin) genetic 1 1 1 Negative Genetic
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer genetic 1 1 1 Negative Genetic
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
SEC63 YOR254C Essential subunit of Sec63 complex physical 1 1 1 Two-hybrid
SEC63 YOR254C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
CSE1 YGL238W Nuclear envelope protein that acts as a recycling factor genetic 1 1 1 Negative Genetic
SEC7 YDR170C Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors physical 1 1 1 Affinity Capture-MS
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 1 1 1 Negative Genetic
SIF2 YBR103W WD40 repeat-containing subunit of Set3C histone deacetylase complex genetic 1 1 1 Negative Genetic
HOS4 YIL112W Subunit of the Set3 complex physical 1 1 1 Biochemical Activity
SET3 YKR029C Defining member of the SET3 histone deacetylase complex genetic 1 1 1 Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
NET1 YJL076W Core subunit of the RENT complex physical 1 1 1 Affinity Capture-MS
CCT2 YIL142W Subunit beta of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
HRK1 YOR267C Protein kinase physical 1 1 1 Affinity Capture-MS
HRK1 YOR267C Protein kinase genetic 1 1 1 Positive Genetic
SKI6 YGR195W Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
SLA1 YBL007C Cytoskeletal protein binding protein genetic 1 1 1 Negative Genetic
BSP1 YPR171W Adapter that links synaptojanins to the cortical actin cytoskeleton physical 1 1 1 Biochemical Activity
BSP1 YPR171W Adapter that links synaptojanins to the cortical actin cytoskeleton genetic 1 1 1 Negative Genetic
SLY1 YDR189W Hydrophilic protein involved in ER/Golgi vesicle trafficking genetic 1 1 1 Negative Genetic
CCT8 YJL008C Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
SMD2 YLR275W Core Sm protein Sm D2 genetic 1 1 1 Negative Genetic
GAL83 YER027C One of three alternate beta-subunits of the Snf1 kinase complex genetic 1 1 1 Phenotypic Suppression
YPK2 YMR104C AGC-type S/T protein kinase physical 1 1 1 Affinity Capture-MS
YPK2 YMR104C AGC-type S/T protein kinase genetic 1 1 1 Negative Genetic
UBI4 YLL039C Ubiquitin genetic 1 1 1 Negative Genetic
STD1 YOR047C Protein involved in control of glucose-regulated gene expression genetic 1 1 1 Negative Genetic
SSA2 YLL024C HSP70 family ATP-binding protein physical 1 1 1 Affinity Capture-MS
YBL055C YBL055C 3'-->5' exonuclease and endonuclease with a possible role in apoptosis physical 1 1 1 Biochemical Activity
TPO3 YPR156C Polyamine transporter of the major facilitator superfamily physical 1 1 1 Biochemical Activity
TOM71 YHR117W Mitochondrial outer membrane protein physical 1 1 1 Biochemical Activity
UBP10 YNL186W Ubiquitin-specific protease, deubiquitinates Ub-protein moieties physical 1 1 1 Biochemical Activity
UBP10 YNL186W Ubiquitin-specific protease, deubiquitinates Ub-protein moieties genetic 1 1 1 Synthetic Growth Defect
TRM1 YDR120C tRNA methyltransferase physical 1 1 1 Biochemical Activity
VHS3 YOR054C Negative regulatory subunit of protein phosphatase 1 Ppz1p physical 1 1 1 Biochemical Activity
UBP7 YIL156W Ubiquitin-specific protease that cleaves ubiquitin-protein fusions physical 1 1 1 Biochemical Activity
YAT2 YER024W Carnitine acetyltransferase physical 1 1 1 Biochemical Activity
SSF2 YDR312W Protein required for ribosomal large subunit maturation physical 1 1 1 Biochemical Activity
SSD1 YDR293C Translational repressor physical 1 1 1 Biochemical Activity
TES1 YJR019C Peroxisomal acyl-CoA thioesterase physical 1 1 1 Biochemical Activity
STM1 YLR150W Protein required for optimal translation under nutrient stress physical 1 1 1 Biochemical Activity
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 1 1 1 Biochemical Activity
UBP6 YFR010W Ubiquitin-specific protease physical 1 1 1 Biochemical Activity
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Negative Genetic
STI1 YOR027W Evolutionarily-conserved Hsp90 cochaperone physical 1 1 1 Reconstituted Complex
STR3 YGL184C Peroxisomal cystathionine beta-lyase physical 1 1 1 Reconstituted Complex
YKL091C YKL091C Putative phosphatidylinositol/phosphatidylcholine transfer protein physical 1 1 1 Reconstituted Complex
USB1 YLR132C Putative poly(U)-specific 3'-to-5' RNA exonuclease physical 1 1 1 Reconstituted Complex
YNL284C-A YNL284C-A Retrotransposon TYA Gag gene co-transcribed with TYB Pol physical 1 1 1 Reconstituted Complex
YPR158C-C YPR158C-C Retrotransposon TYA Gag gene co-transcribed with TYB Pol physical 1 1 1 Reconstituted Complex
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 1 1 1 Synthetic Growth Defect
SRB6 YBR253W Subunit of the RNA polymerase II mediator complex physical 1 1 1 PCA
TOS4 YLR183C Putative transcription factor, contains Forkhead Associated domain physical 1 1 1 Two-hybrid
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
TDH2 YJR009C Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2 physical 1 1 1 Affinity Capture-MS
TDH3 YGR192C Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 3 physical 1 1 1 Affinity Capture-MS
TAL1 YLR354C Transaldolase, enzyme in the non-oxidative pentose phosphate pathway physical 1 1 1 Affinity Capture-MS
TEF1 YPR080W Translational elongation factor EF-1 alpha physical 1 1 1 Affinity Capture-MS
SSC1 YJR045C Hsp70 family ATPase physical 1 1 1 Affinity Capture-MS
SSC1 YJR045C Hsp70 family ATPase genetic 1 1 1 Phenotypic Suppression
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Biochemical Activity
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
SPF1 YEL031W P-type ATPase, ion transporter of the ER membrane physical 1 1 1 Affinity Capture-MS
TUB3 YML124C Alpha-tubulin genetic 1 1 1 Dosage Rescue
SRB8 YCR081W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Rescue
TRK1 YJL129C Component of the Trk1p-Trk2p potassium transport system genetic 1 1 1 Dosage Rescue
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 1 1 1 Negative Genetic
URA5 YML106W Major orotate phosphoribosyltransferase (OPRTase) isozyme genetic 1 1 1 Negative Genetic
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Negative Genetic
SPT23 YKL020C ER membrane protein involved in regulation of OLE1 transcription genetic 1 1 1 Negative Genetic
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 1 1 1 Positive Genetic
VHS1 YDR247W Cytoplasmic serine/threonine protein kinase genetic 1 1 1 Negative Genetic
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Negative Genetic
YCK3 YER123W Palmitoylated vacuolar membrane-localized casein kinase I isoform genetic 1 1 1 Negative Genetic
YCK2 YNL154C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform genetic 1 1 1 Negative Genetic
SPO14 YKR031C Phospholipase D genetic 1 1 1 Negative Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Positive Genetic
TCO89 YPL180W Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p) genetic 1 1 1 Positive Genetic
TRA1 YHR099W Subunit of SAGA and NuA4 histone acetyltransferase complexes genetic 1 1 1 Synthetic Growth Defect
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Lethality
YCK1 YHR135C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform genetic 1 1 1 Dosage Rescue
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Synthetic Growth Defect
VOA1 YGR106C ER protein that functions in assembly of the V0 sector of V-ATPase genetic 1 1 1 Synthetic Growth Defect
TOS3 YGL179C Protein kinase genetic 1 1 1 Positive Genetic
UPC2 YDR213W Sterol regulatory element binding protein genetic 1 1 1 Negative Genetic
STE24 YJR117W Highly conserved zinc metalloprotease genetic 1 1 1 Negative Genetic
VPH2 YKL119C Integral membrane protein required for V-ATPase function genetic 1 1 1 Negative Genetic
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting genetic 1 1 1 Negative Genetic
UPS1 YLR193C Phosphatidic acid transfer protein genetic 1 1 1 Negative Genetic
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) genetic 1 1 1 Negative Genetic
YTA12 YMR089C Mitochondrial inner membrane m-AAA protease component genetic 1 1 1 Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Negative Genetic
TLG2 YOL018C Syntaxin-like t-SNARE genetic 1 1 1 Negative Genetic
VMA11 YPL234C Vacuolar ATPase V0 domain subunit c' genetic 1 1 1 Negative Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Negative Genetic
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Negative Genetic
TEP1 YNL128W PTEN homolog with no demonstrated inositol lipid phosphatase activity genetic 1 1 1 Negative Genetic
SNF3 YDL194W Plasma membrane low glucose sensor, regulates glucose transport genetic 1 1 1 Dosage Growth Defect
YKR075C YKR075C Protein of unknown function genetic 1 1 1 Dosage Growth Defect
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Synthetic Rescue
SSK1 YLR006C Cytoplasmic phosphorelay intermediate osmosensor and regulator genetic 1 1 1 Synthetic Rescue
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 1 1 1 Positive Genetic
TIM22 YDL217C Essential core component of mitochondrial TIM22 complex genetic 1 1 1 Positive Genetic
TAO3 YIL129C Component of the RAM signaling network genetic 1 1 1 Positive Genetic
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Positive Genetic
STP22 YCL008C Component of the ESCRT-I complex genetic 1 1 1 Positive Genetic
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE genetic 1 1 1 Positive Genetic
SNF6 YHL025W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Positive Genetic
TUL1 YKL034W Subunit of the DSC ubiquitin ligase complex genetic 1 1 1 Positive Genetic
YML054C-A YML054C-A Putative protein of unknown function genetic 1 1 1 Positive Genetic
TCB3 YML072C Cortical ER protein involved in ER-plasma membrane tethering genetic 1 1 1 Positive Genetic
YMR084W YMR084W Putative protein of unknown function genetic 1 1 1 Positive Genetic
YPI1 YFR003C Regulatory subunit of the type I protein phosphatase (PP1) Glc7p genetic 1 1 1 Negative Genetic
TIM54 YJL054W Component of the mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
URA6 YKL024C Uridylate kinase genetic 1 1 1 Negative Genetic
SRP102 YKL154W Signal recognition particle (SRP) receptor beta subunit genetic 1 1 1 Negative Genetic
YKT6 YKL196C Vesicle membrane protein (v-SNARE) with acyltransferase activity genetic 1 1 1 Negative Genetic
TOR2 YKL203C PIK-related protein kinase and rapamycin target genetic 1 1 1 Negative Genetic
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 1 1 1 Negative Genetic
STT4 YLR305C Phosphatidylinositol-4-kinase genetic 1 1 1 Negative Genetic
VTI1 YMR197C Protein involved in cis-Golgi membrane traffic genetic 1 1 1 Negative Genetic
SRV2 YNL138W CAP (cyclase-associated protein) genetic 1 1 1 Negative Genetic
SUI3 YPL237W Beta subunit of the translation initiation factor eIF2 genetic 1 1 1 Negative Genetic
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l genetic 1 1 1 Negative Genetic
TYS1 YGR185C Cytoplasmic tyrosyl-tRNA synthetase genetic 1 1 1 Negative Genetic
TAD3 YLR316C Subunit of tRNA-specific adenosine-34 deaminase genetic 1 1 1 Negative Genetic
VID24 YBR105C GID Complex regulatory subunit genetic 1 1 1 Negative Genetic
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes genetic 1 1 1 Negative Genetic
YPT10 YBR264C Rab family GTP-binding protein genetic 1 1 1 Negative Genetic
SSH1 YBR283C Subunit of the Ssh1 translocon complex genetic 1 1 1 Negative Genetic
TFB5 YDR079C-A Component of RNA polymerase II general transcription factor TFIIH genetic 1 1 1 Negative Genetic
YBL036C YBL036C Putative non-specific single-domain racemase genetic 1 1 1 Negative Genetic
YCR090C YCR090C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YPS1 YLR120C Aspartic protease genetic 1 1 1 Negative Genetic
SRC1 YML034W Inner nuclear membrane protein genetic 1 1 1 Negative Genetic
SOK2 YMR016C Nuclear protein that negatively regulates pseudohyphal differentiation genetic 1 1 1 Negative Genetic
SSO2 YMR183C Plasma membrane t-SNARE genetic 1 1 1 Negative Genetic
YPT31 YER031C Rab family GTPase genetic 1 1 1 Negative Genetic
UPF3 YGR072W Component of the nonsense-mediated mRNA decay (NMD) pathway genetic 1 1 1 Negative Genetic
YCH1 YGR203W Phosphatase with sequence similarity to Mih1p genetic 1 1 1 Negative Genetic
SOL4 YGR248W 6-phosphogluconolactonase genetic 1 1 1 Negative Genetic
YHL017W YHL017W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YHR050W-A YHR050W-A Protein of unknown function genetic 1 1 1 Negative Genetic
YIL014C-A YIL014C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
VID28 YIL017C GID Complex subunit, serves as adaptor for regulatory subunit Vid24p genetic 1 1 1 Negative Genetic
SYS1 YJL004C Integral membrane protein of the Golgi genetic 1 1 1 Negative Genetic
YJL027C YJL027C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YIL092W YIL092W Putative protein of unknown function genetic 1 1 1 Phenotypic Suppression
TOF2 YKR010C Protein required for rDNA silencing and mitotic rDNA condensation genetic 1 1 1 Negative Genetic
YKR018C YKR018C Protein of unknown function genetic 1 1 1 Negative Genetic
YLL054C YLL054C Putative protein of unknown function with similarity to Pip2p genetic 1 1 1 Negative Genetic
UCC1 YLR224W F-box protein and component of SCF ubiquitin ligase complexes genetic 1 1 1 Negative Genetic
VRP1 YLR337C Verprolin, proline-rich actin-associated protein genetic 1 1 1 Negative Genetic
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor genetic 1 1 1 Negative Genetic
SUR7 YML052W Plasma membrane protein, component of eisosomes genetic 1 1 1 Negative Genetic
YML100W-A YML100W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YMR196W YMR196W Putative protein of unknown function genetic 1 1 1 Negative Genetic
ZWF1 YNL241C Glucose-6-phosphate dehydrogenase (G6PD) genetic 1 1 1 Negative Genetic
YOL159C-A YOL159C-A Protein of unknown function genetic 1 1 1 Negative Genetic
TUF1 YOR187W Mitochondrial translation elongation factor Tu (EF-Tu) genetic 1 1 1 Negative Genetic
ULA1 YPL003W Protein that activates Rub1p (NEDD8) before neddylation genetic 1 1 1 Negative Genetic
SUV3 YPL029W ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
USV1 YPL230W Putative transcription factor containing a C2H2 zinc finger genetic 1 1 1 Negative Genetic
SWI3 YJL176C Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Negative Genetic
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
YEL1 YBL060W Guanine nucleotide exchange factor specific for Arf3p genetic 1 1 1 Phenotypic Enhancement
UBR2 YLR024C Cytoplasmic ubiquitin-protein ligase (E3) genetic 1 1 1 Phenotypic Suppression
TCP1 YDR212W Alpha subunit of chaperonin-containing T-complex genetic 1 1 1 Phenotypic Suppression
UBX4 YMR067C UBX domain-containing protein that interacts with Cdc48p genetic 1 1 1 Synthetic Rescue
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Growth Defect
PFK2 YMR205C Beta subunit of heterooctameric phosphofructokinase physical 1 1 1 Biochemical Activity
PFK2 YMR205C Beta subunit of heterooctameric phosphofructokinase genetic 1 1 1 Synthetic Rescue
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 1 1 1 Negative Genetic
SEC65 YML105C Subunit of the signal recognition particle (SRP) genetic 1 1 1 Negative Genetic
SEN1 YLR430W ATP-dependent 5' to 3' RNA/DNA and DNA helicase genetic 1 1 1 Negative Genetic
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Negative Genetic
SEN54 YPL083C Subunit of the tRNA splicing endonuclease genetic 1 1 1 Negative Genetic
PSK1 YAL017W PAS domain-containing serine/threonine protein kinase physical 1 1 1 Biochemical Activity
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Reconstituted Complex
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
RTS3 YGR161C Putative component of the protein phosphatase type 2A complex genetic 1 1 1 Negative Genetic
BCY1 YIL033C Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) genetic 1 1 1 Negative Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 1 1 1 Synthetic Growth Defect
ECM30 YLR436C Protein of unknown function genetic 1 1 1 Negative Genetic
DRE2 YKR071C Component of the cytosolic Fe-S protein assembly (CIA) machinery physical 1 1 1 Biochemical Activity
RGC1 YPR115W Putative regulator of the Fps1p glycerol channel physical 1 1 1 Biochemical Activity
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
GET3 YDL100C Guanine nucleotide exchange factor for Gpa1p genetic 1 1 1 Negative Genetic
CMS1 YLR003C Putative subunit of the 90S preribosome processome complex physical 1 1 1 Reconstituted Complex
ATP2 YJR121W Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase physical 1 1 1 Affinity Capture-MS
ATP2 YJR121W Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase genetic 1 1 1 Synthetic Growth Defect
GET4 YOR164C Protein involved in inserting tail-anchored proteins into ER membranes genetic 1 1 1 Negative Genetic
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails physical 1 1 1 Biochemical Activity
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Negative Genetic
EGD2 YHR193C Alpha subunit of the nascent polypeptide-associated complex (NAC) genetic 1 1 1 Phenotypic Suppression
ACO1 YLR304C Aconitase genetic 1 1 1 Negative Genetic
MSD1 YPL104W Mitochondrial aspartyl-tRNA synthetase genetic 1 1 1 Negative Genetic
PHO84 YML123C High-affinity inorganic phosphate (Pi) transporter genetic 1 1 1 Synthetic Rescue
ADR1 YDR216W Carbon source-responsive zinc-finger transcription factor physical 1 1 1 Co-localization
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
CDC5 YMR001C Polo-like kinase required for mitotic exit physical 1 1 1 Affinity Capture-MS
GPP1 YIL053W Constitutively expressed DL-glycerol-3-phosphate phosphatase genetic 1 1 1 Negative Genetic
ARF1 YDL192W ADP-ribosylation factor physical 1 1 1 Affinity Capture-MS
PRB1 YEL060C Vacuolar proteinase B (yscB) with H3 N-terminal endopeptidase activity physical 1 1 1 Affinity Capture-MS
RTK1 YDL025C Putative protein kinase, potentially phosphorylated by Cdc28p physical 1 1 1 Biochemical Activity
BUB2 YMR055C Mitotic exit network regulator genetic 1 1 1 Synthetic Growth Defect
AHP1 YLR109W Thiol-specific peroxiredoxin genetic 1 1 1 Negative Genetic
CNA1 YLR433C Calcineurin A genetic 1 1 1 Synthetic Growth Defect
CMP2 YML057W Calcineurin A genetic 1 1 1 Synthetic Growth Defect
GRR1 YJR090C F-box protein component of an SCF ubiquitin-ligase complex genetic 1 1 1 Synthetic Lethality
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway genetic 1 1 1 Phenotypic Enhancement
GSF2 YML048W Endoplasmic reticulum (ER) localized integral membrane protein physical 1 1 1 Reconstituted Complex
OYE3 YPL171C Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) genetic 1 1 1 Negative Genetic
FKH1 YIL131C Forkhead family transcription factor genetic 1 1 1 Synthetic Growth Defect
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Negative Genetic
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 1 1 1 Positive Genetic
GLC8 YMR311C Regulatory subunit of protein phosphatase 1 (Glc7p) genetic 1 1 1 Positive Genetic
CMK1 YFR014C Calmodulin-dependent protein kinase genetic 1 1 1 Positive Genetic
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Positive Genetic
COF1 YLL050C Cofilin, involved in pH-dependent actin filament depolarization genetic 1 1 1 Negative Genetic
GPD2 YOL059W NAD-dependent glycerol 3-phosphate dehydrogenase physical 1 1 1 Biochemical Activity
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
INM1 YHR046C Inositol monophosphatase genetic 1 1 1 Positive Genetic
ELA1 YNL230C Elongin A genetic 1 1 1 Positive Genetic
LAF1 YMR102C Sterol-binding beta-propeller protein physical 1 1 1 Biochemical Activity
GAC1 YOR178C Regulatory subunit for Glc7p type-1 protein phosphatase (PP1) genetic 1 1 1 Dosage Rescue
PDS1 YDR113C Securin physical 1 1 1 Biochemical Activity
ELM1 YKL048C Serine/threonine protein kinase physical 1 1 1 Biochemical Activity
MSI1 YBR195C Subunit of chromatin assembly factor I (CAF-1) genetic 1 1 1 Dosage Rescue
CAT5 YOR125C Protein required for ubiquinone (Coenzyme Q) biosynthesis genetic 1 1 1 Negative Genetic
IMD4 YML056C Inosine monophosphate dehydrogenase physical 1 1 1 Affinity Capture-MS
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 1 1 1 Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase physical 1 1 1 Biochemical Activity
ADH4 YGL256W Alcohol dehydrogenase isoenzyme type IV genetic 1 1 1 Negative Genetic
IPA1 YJR141W Protein implicated in pre-mRNA processing and proteasomal degradation genetic 1 1 1 Negative Genetic
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 1 1 1 Positive Genetic
MAK11 YKL021C Protein involved in an early step of 60S ribosomal subunit biogenesis genetic 1 1 1 Negative Genetic
GND2 YGR256W 6-phosphogluconate dehydrogenase (decarboxylating) physical 1 1 1 Reconstituted Complex
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 1 1 1 Negative Genetic
RPP0 YLR340W Conserved ribosomal protein P0 of the ribosomal stalk physical 1 1 1 Affinity Capture-MS
ISU1 YPL135W Conserved protein of the mitochondrial matrix genetic 1 1 1 Phenotypic Enhancement
SHE3 YBR130C Protein adaptor between Myo4p and the She2p-mRNA complex physical 1 1 1 Biochemical Activity
HHT1 YBR010W Histone H3 physical 1 1 1 Biochemical Activity
SEG1 YMR086W Component of eisosome required for proper eisosome assembly physical 1 1 1 Affinity Capture-MS
IRA1 YBR140C GTPase-activating protein genetic 1 1 1 Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Synthetic Growth Defect
RCK1 YGL158W Protein kinase involved in oxidative stress response physical 1 1 1 Affinity Capture-MS
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 1 1 1 Negative Genetic
LHS1 YKL073W Molecular chaperone of the endoplasmic reticulum lumen genetic 1 1 1 Phenotypic Suppression
SHS1 YDL225W Component of the septin ring that is required for cytokinesis physical 1 1 1 Biochemical Activity
NUS1 YDL193W Forms dehydrodolichyl diphosphate synthase complex with RER2 or SRT1 genetic 1 1 1 Negative Genetic
OPY1 YBR129C Protein of unknown function genetic 1 1 1 Negative Genetic
ATG20 YDL113C Sorting nexin family member genetic 1 1 1 Negative Genetic
ATG4 YNL223W Conserved cysteine protease required for autophagy genetic 1 1 1 Negative Genetic
NOP13 YNL175C Nucleolar protein found in preribosomal complexes genetic 1 1 1 Negative Genetic
SEC4 YFL005W Rab family GTPase genetic 1 1 1 Negative Genetic
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 1 1 1 Positive Genetic
AHC1 YOR023C Subunit of the Ada histone acetyltransferase complex genetic 1 1 1 Negative Genetic
NOP53 YPL146C Nucleolar protein physical 1 1 1 Biochemical Activity
NOP53 YPL146C Nucleolar protein genetic 1 1 1 Positive Genetic
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 1 1 1 Synthetic Growth Defect
RTT103 YDR289C Protein involved in transcription termination by RNA polymerase II genetic 1 1 1 Negative Genetic
HAP3 YBL021C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Negative Genetic
FKH2 YNL068C Forkhead family transcription factor genetic 1 1 1 Synthetic Growth Defect
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response physical 1 1 1 Affinity Capture-MS
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Positive Genetic
PPZ1 YML016C Serine/threonine protein phosphatase Z, isoform of Ppz2p genetic 1 1 1 Positive Genetic
SKT5 YBL061C Activator of Chs3p (chitin synthase III) during vegetative growth physical 1 1 1 Biochemical Activity
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating physical 1 1 1 Two-hybrid
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 1 1 1 Positive Genetic
ISA1 YLL027W Protein required for maturation of mitochondrial [4Fe-4S] proteins physical 1 1 1 Biochemical Activity
CBP2 YHL038C Required for splicing of the group I intron bI5 of the COB pre-mRNA genetic 1 1 1 Negative Genetic
PMI40 YER003C Mannose-6-phosphate isomerase genetic 1 1 1 Negative Genetic
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Negative Genetic
EXO70 YJL085W Subunit of the exocyst complex genetic 1 1 1 Negative Genetic
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Negative Genetic
JJJ1 YNL227C Co-chaperone that stimulates the ATPase activity of Ssa1p physical 1 1 1 Biochemical Activity
RNR3 YIL066C Minor isoform of large subunit of ribonucleotide-diphosphate reductase genetic 1 1 1 Negative Genetic
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
AFG3 YER017C Mitochondrial inner membrane m-AAA protease component genetic 1 1 1 Negative Genetic
RPL5 YPL131W Ribosomal 60S subunit protein L5 physical 1 1 1 Affinity Capture-MS
RHO4 YKR055W Non-essential small GTPase genetic 1 1 1 Negative Genetic
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 1 1 1 Negative Genetic
DCK1 YLR422W Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1 genetic 1 1 1 Positive Genetic
MTQ2 YDR140W S-adenosylmethionine-dependent methyltransferase physical 1 1 1 Affinity Capture-MS
FZF1 YGL254W Transcription factor involved in sulfite metabolism genetic 1 1 1 Negative Genetic
SKA1 YKL023W SKI complex-associated protein physical 1 1 1 Biochemical Activity
DID4 YKL002W Class E Vps protein of the ESCRT-III complex genetic 1 1 1 Negative Genetic
LAC1 YKL008C Ceramide synthase component physical 1 1 1 Biochemical Activity
ATG13 YPR185W Regulatory subunit of the Atg1p signaling complex genetic 1 1 1 Dosage Rescue
ATG16 YMR159C Conserved protein involved in autophagy genetic 1 1 1 Negative Genetic
CDD1 YLR245C Cytidine deaminase genetic 1 1 1 Negative Genetic
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis genetic 1 1 1 Negative Genetic
GZF3 YJL110C GATA zinc finger protein physical 1 1 1 Biochemical Activity
SMT3 YDR510W Ubiquitin-like protein of the SUMO family physical 1 1 1 Affinity Capture-MS
HCS1 YKL017C Hexameric DNA polymerase alpha-associated DNA helicase A genetic 1 1 1 Negative Genetic
ATG19 YOL082W Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway genetic 1 1 1 Positive Genetic
GCN4 YEL009C bZIP transcriptional activator of amino acid biosynthetic genes genetic 1 1 1 Phenotypic Enhancement
MSN5 YDR335W Karyopherin genetic 1 1 1 Dosage Rescue
NUF2 YOL069W Component of the kinetochore-associated Ndc80 complex physical 1 1 1 Two-hybrid
ALY2 YJL084C Alpha arrestin, Ub-ligase adaptor for Rsp5p physical 1 1 1 Biochemical Activity
CLG1 YGL215W Cyclin-like protein that interacts with Pho85p genetic 1 1 1 Negative Genetic
CSM3 YMR048W Replication fork associated factor genetic 1 1 1 Negative Genetic
SEC10 YLR166C Essential 100kDa subunit of the exocyst complex genetic 1 1 1 Dosage Rescue
ERC1 YHR032W Member of the multi-drug and toxin extrusion (MATE) family genetic 1 1 1 Phenotypic Suppression
KEG1 YFR042W Integral membrane protein of the ER genetic 1 1 1 Positive Genetic
PNS1 YOR161C Protein of unknown function genetic 1 1 1 Negative Genetic
AKR2 YOR034C Ankyrin repeat-containing protein genetic 1 1 1 Negative Genetic
GPI16 YHR188C Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Negative Genetic
MDY2 YOL111C Protein involved in inserting tail-anchored proteins into ER membranes genetic 1 1 1 Negative Genetic
NPR2 YEL062W Subunit of the Iml1p/SEACIT complex genetic 1 1 1 Negative Genetic
OCA2 YNL056W Protein of unknown function genetic 1 1 1 Negative Genetic
COG4 YPR105C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
BOS1 YLR078C v-SNARE (vesicle specific SNAP receptor) genetic 1 1 1 Negative Genetic
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Synthetic Growth Defect
APC4 YDR118W Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 1 1 1 Two-hybrid
COG6 YNL041C Component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
ELP3 YPL086C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
ELP4 YPL101W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Negative Genetic
IPL1 YPL209C Aurora kinase of chromosomal passenger complex genetic 1 1 1 Positive Genetic
RPL4A YBR031W Ribosomal 60S subunit protein L4A physical 1 1 1 Affinity Capture-MS
PEX13 YLR191W Peroxisomal importomer complex component physical 1 1 1 Two-hybrid
RLP24 YLR009W Essential protein required for ribosomal large subunit biogenesis genetic 1 1 1 Negative Genetic
RPL23B YER117W Ribosomal 60S subunit protein L23B physical 1 1 1 Affinity Capture-MS
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 1 1 1 Negative Genetic
SFH1 YLR321C Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
MSN2 YMR037C Stress-responsive transcriptional activator physical 1 1 1 Biochemical Activity
PHO4 YFR034C Basic helix-loop-helix (bHLH) transcription factor of the myc-family physical 1 1 1 Affinity Capture-MS
PHO4 YFR034C Basic helix-loop-helix (bHLH) transcription factor of the myc-family genetic 1 1 1 Phenotypic Enhancement
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS8B YER102W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS11A YDR025W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
PLC1 YPL268W Phospholipase C genetic 1 1 1 Negative Genetic
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex genetic 1 1 1 Positive Genetic
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Biochemical Activity
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase genetic 1 1 1 Positive Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 1 1 1 Positive Genetic
CTK2 YJL006C Beta subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Negative Genetic
KAR9 YPL269W Spindle positioning factor genetic 1 1 1 Phenotypic Suppression
MYO5 YMR109W One of two type I myosin motors genetic 1 1 1 Negative Genetic
NRG1 YDR043C Transcriptional repressor physical 1 1 1 Affinity Capture-Western
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 1 1 1 Negative Genetic
PHO80 YOL001W Cyclin genetic 1 1 1 Negative Genetic
PUP1 YOR157C Beta 2 subunit of the 20S proteasome genetic 1 1 1 Positive Genetic
RPA14 YDR156W RNA polymerase I subunit A14 genetic 1 1 1 Negative Genetic
SEC15 YGL233W Essential 113 kDa subunit of the exocyst complex genetic 1 1 1 Dosage Rescue
BET1 YIL004C Type II membrane protein required for vesicular transport genetic 1 1 1 Negative Genetic
RRD1 YIL153W Peptidyl-prolyl cis/trans-isomerase genetic 1 1 1 Positive Genetic
SKN7 YHR206W Nuclear response regulator and transcription factor genetic 1 1 1 Negative Genetic
FIG4 YNL325C Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase genetic 1 1 1 Positive Genetic
CNM67 YNL225C Component of the spindle pole body outer plaque physical 1 1 1 Reconstituted Complex
SEC16 YPL085W COPII vesicle coat protein required for ER transport vesicle budding genetic 1 1 1 Negative Genetic
GAL4 YPL248C DNA-binding transcription factor required for activating GAL genes genetic 1 1 1 Negative Genetic
KAR2 YJL034W ATPase involved in protein import into the ER genetic 1 1 1 Negative Genetic
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system genetic 1 1 1 Positive Genetic
MOB1 YIL106W Component of the mitotic exit network genetic 1 1 1 Negative Genetic
NUP170 YBL079W Subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Synthetic Growth Defect
SEC24 YIL109C Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat genetic 1 1 1 Negative Genetic
SEC2 YNL272C Guanyl-nucleotide exchange factor for the small G-protein Sec4p physical 1 1 1 Biochemical Activity
SEC2 YNL272C Guanyl-nucleotide exchange factor for the small G-protein Sec4p genetic 1 1 1 Dosage Rescue
EMC1 YCL045C Member of conserved endoplasmic reticulum membrane complex genetic 1 1 1 Negative Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Negative Genetic
SML1 YML058W Ribonucleotide reductase inhibitor genetic 1 1 1 Synthetic Growth Defect
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 1 1 1 Positive Genetic
MUD2 YKL074C Protein involved in early pre-mRNA splicing genetic 1 1 1 Positive Genetic
GAL1 YBR020W Galactokinase genetic 1 1 1 Positive Genetic
GSY2 YLR258W Glycogen synthase genetic 1 1 1 Phenotypic Suppression
GTS1 YGL181W Protein involved in Arf3p regulation and in transcription regulation genetic 1 1 1 Positive Genetic
CDC19 YAL038W Pyruvate kinase physical 1 1 1 Affinity Capture-MS
RLM1 YPL089C MADS-box transcription factor genetic 1 1 1 Synthetic Growth Defect
GFD2 YCL036W Protein of unknown function genetic 1 1 1 Negative Genetic
OSH3 YHR073W Member of an oxysterol-binding protein family physical 1 1 1 Biochemical Activity
AZF1 YOR113W Zinc-finger transcription factor genetic 1 1 1 Negative Genetic
RPL1A YPL220W Ribosomal 60S subunit protein L1A physical 1 1 1 Affinity Capture-MS
RPL1B YGL135W Ribosomal 60S subunit protein L1B physical 1 1 1 Affinity Capture-MS
RPL1B YGL135W Ribosomal 60S subunit protein L1B genetic 1 1 1 Negative Genetic
NIP100 YPL174C Large subunit of the dynactin complex genetic 1 1 1 Negative Genetic
PFY1 YOR122C Profilin genetic 1 1 1 Synthetic Growth Defect
CQD1 YPL109C UbiB family mitochondrial protein genetic 1 1 1 Negative Genetic
COX17 YLL009C Copper metallochaperone that transfers copper to Sco1p and Cox11p genetic 1 1 1 Positive Genetic
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
HSV2 YGR223C Phosphatidylinositol 3,5-bisphosphate-binding protein genetic 1 1 1 Negative Genetic
CAP2 YIL034C Beta subunit of the capping protein heterodimer (Cap1p and Cap2p) genetic 1 1 1 Negative Genetic
RPS2 YGL123W Protein component of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS2 YGL123W Protein component of the small (40S) subunit genetic 1 1 1 Negative Genetic
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
DID2 YKR035W-A Class E protein of the vacuolar protein-sorting (Vps) pathway genetic 1 1 1 Negative Genetic
GSM1 YJL103C Putative zinc cluster protein of unknown function physical 1 1 1 Biochemical Activity
ASN1 YPR145W Asparagine synthetase genetic 1 1 1 Negative Genetic
BET4 YJL031C Alpha subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
RPL11A YPR102C Ribosomal 60S subunit protein L11A genetic 1 1 1 Negative Genetic
PRS4 YBL068W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP genetic 1 1 1 Negative Genetic
ARL3 YPL051W ARF-like small GTPase of the RAS superfamily genetic 1 1 1 Negative Genetic
COX14 YML129C Mitochondrial cytochrome c oxidase (complex IV) assembly factor genetic 1 1 1 Negative Genetic
RNR4 YGR180C Ribonucleotide-diphosphate reductase (RNR) small subunit genetic 1 1 1 Synthetic Growth Defect
COX19 YLL018C-A Protein required for cytochrome c oxidase assembly genetic 1 1 1 Negative Genetic
MIP1 YOR330C Mitochondrial DNA polymerase gamma genetic 1 1 1 Negative Genetic
RPS20 YHL015W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Reconstituted Complex
EFT1 YOR133W Elongation factor 2 (EF-2), also encoded by EFT2 physical 1 1 1 Affinity Capture-MS
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
FOX2 YKR009C 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase physical 1 1 1 Biochemical Activity
GAB1 YLR459W Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Negative Genetic
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia genetic 1 1 1 Negative Genetic
RPL7A YGL076C Ribosomal 60S subunit protein L7A physical 1 1 1 Affinity Capture-MS
DPM1 YPR183W Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane genetic 1 1 1 Negative Genetic
ERG5 YMR015C C-22 sterol desaturase physical 1 1 1 Biochemical Activity
LYS21 YDL131W Homocitrate synthase isozyme physical 1 1 1 Affinity Capture-MS
SBE22 YHR103W Protein involved in bud growth physical 1 1 1 Biochemical Activity
EMC6 YLL014W Member of conserved ER transmembrane complex genetic 1 1 1 Negative Genetic
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 1 1 1 Phenotypic Suppression
PAC1 YOR269W Regulator of dynein, involved in intracellular transport physical 1 1 1 Reconstituted Complex
PBN1 YCL052C Component of glycosylphosphatidylinositol-mannosyltransferase I genetic 1 1 1 Negative Genetic
GLR1 YPL091W Cytosolic and mitochondrial glutathione oxidoreductase genetic 1 1 1 Dosage Rescue
HMG1 YML075C HMG-CoA reductase genetic 1 1 1 Negative Genetic
ATP18 YML081C-A Subunit of the mitochondrial F1F0 ATP synthase genetic 1 1 1 Negative Genetic
CAT2 YML042W Carnitine acetyl-CoA transferase genetic 1 1 1 Synthetic Rescue
HCM1 YCR065W Forkhead transcription factor physical 1 1 1 Biochemical Activity
CBS2 YDR197W Mitochondrial translational activator of the COB mRNA genetic 1 1 1 Negative Genetic
ALG1 YBR110W Mannosyltransferase genetic 1 1 1 Negative Genetic
HUL4 YJR036C Protein with similarity to hect domain E3 ubiquitin-protein ligases genetic 1 1 1 Negative Genetic
ERI1 YPL096C-A Endoplasmic reticulum membrane protein that binds and inhibits Ras2p genetic 1 1 1 Negative Genetic
RIO1 YOR119C Serine kinase involved in cell cycle regulation and rDNA integrity physical 1 1 1 Two-hybrid
MIG3 YER028C Transcriptional regulator physical 1 1 1 Biochemical Activity
RPL40B YKR094C Ubiquitin-ribosomal 60S subunit protein L40B fusion protein genetic 1 1 1 Negative Genetic
PAH1 YMR165C Mg2+-dependent phosphatidate (PA) phosphatase physical 1 1 1 Biochemical Activity
BTT1 YDR252W Heterotrimeric nascent polypeptide-associated complex beta3 subunit genetic 1 1 1 Negative Genetic
LYS20 YDL182W Homocitrate synthase isozyme and functions in DNA repair physical 1 1 1 Affinity Capture-MS
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 1 1 1 Negative Genetic
COQ10 YOL008W Coenzyme Q (ubiquinone) binding protein genetic 1 1 1 Negative Genetic
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Negative Genetic
BUL2 YML111W Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex physical 1 1 1 Biochemical Activity
PAM1 YDR251W Essential protein of unknown function genetic 1 1 1 Negative Genetic
MRPL17 YNL252C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
RAD30 YDR419W DNA polymerase eta physical 1 1 1 Affinity Capture-MS
MTG1 YMR097C Putative GTPase peripheral to the mitochondrial inner membrane genetic 1 1 1 Negative Genetic
IAI11 YBL059W Putative mitochondrial protein of unknown function genetic 1 1 1 Dosage Growth Defect
LCB5 YLR260W Minor sphingoid long-chain base kinase genetic 1 1 1 Negative Genetic
CUL3 YGR003W Ubiquitin-protein ligase genetic 1 1 1 Negative Genetic
PPT1 YGR123C Protein serine/threonine phosphatase genetic 1 1 1 Negative Genetic
NOP19 YGR251W Ribosome biogenesis factor genetic 1 1 1 Negative Genetic
CAB4 YGR277C Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) genetic 1 1 1 Negative Genetic
GUT1 YHL032C Glycerol kinase genetic 1 1 1 Negative Genetic
RRP15 YPR143W Nucleolar protein physical 1 1 1 Biochemical Activity
RRP15 YPR143W Nucleolar protein genetic 1 1 1 Negative Genetic
BAR1 YIL015W Aspartyl protease secreted to periplasmic space of mating type a cell genetic 1 1 1 Positive Genetic
PDR10 YOR328W ATP-binding cassette (ABC) transporter genetic 1 1 1 Positive Genetic
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 1 1 1 Negative Genetic
ALD6 YPL061W Cytosolic aldehyde dehydrogenase physical 1 1 1 Affinity Capture-MS
IRC8 YJL051W Bud tip localized protein of unknown function genetic 1 1 1 Negative Genetic
BYE1 YKL005C Negative regulator of transcription elongation genetic 1 1 1 Negative Genetic
KIN4 YOR233W Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
DTR1 YBR180W Putative dityrosine transporter of the major facilitator superfamily genetic 1 1 1 Negative Genetic
AQY3 YFL054C Putative channel-like protein physical 1 1 1 Biochemical Activity
SDO1 YLR022C Guanine nucleotide exchange factor (GEF) for Ria1p genetic 1 1 1 Negative Genetic
RIA1 YNL163C Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis genetic 1 1 1 Negative Genetic
NQM1 YGR043C Transaldolase of unknown function physical 1 1 1 Reconstituted Complex
COQ6 YGR255C Flavin-dependent monooxygenase involved in ubiquinone biosynthesis genetic 1 1 1 Negative Genetic
AIM26 YKL037W Protein of unknown function genetic 1 1 1 Negative Genetic
SEC14 YMR079W Phosphatidylinositol/phosphatidylcholine transfer protein genetic 1 1 1 Positive Genetic
HFD1 YMR110C Dehydrogenase involved in ubiquinone and sphingolipid metabolism genetic 1 1 1 Negative Genetic
DSF1 YEL070W Mannitol dehydrogenase genetic 1 1 1 Negative Genetic
FLO11 YIR019C GPI-anchored cell surface glycoprotein (flocculin) genetic 1 1 1 Negative Genetic
ADE12 YNL220W Adenylosuccinate synthase genetic 1 1 1 Negative Genetic
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites genetic 1 1 1 Dosage Rescue
RGL1 YPL066W Regulator of Rho1p signaling, cofactor of Tus1p genetic 1 1 1 Negative Genetic
FAS1 YKL182W Beta subunit of fatty acid synthetase genetic 1 1 1 Synthetic Rescue
PFK26 YIL107C 6-phosphofructo-2-kinase physical 1 1 1 Biochemical Activity
RIM4 YHL024W Putative RNA-binding protein physical 1 1 1 Reconstituted Complex
PET130 YJL023C Protein of unknown function genetic 1 1 1 Negative Genetic
COA3 YJL062W-A Mitochondrial protein required for cytochrome c oxidase assembly genetic 1 1 1 Negative Genetic
GEP5 YLR091W Protein of unknown function genetic 1 1 1 Negative Genetic
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 1 1 1 Negative Genetic
RPL4B YDR012W Ribosomal 60S subunit protein L4B genetic 1 1 1 Negative Genetic
RPL17B YJL177W Ribosomal 60S subunit protein L17B physical 1 1 1 Affinity Capture-MS
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
MRPL27 YBR282W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
GEM1 YAL048C Outer mitochondrial membrane GTPase, subunit of the ERMES complex genetic 1 1 1 Synthetic Growth Defect
RPL6B YLR448W Ribosomal 60S subunit protein L6B physical 1 1 1 Affinity Capture-MS
RPL6A YML073C Ribosomal 60S subunit protein L6A physical 1 1 1 Affinity Capture-MS
OPY2 YPR075C Integral membrane protein that acts as a membrane anchor for Ste50p genetic 1 1 1 Negative Genetic
ARO2 YGL148W Bifunctional chorismate synthase and flavin reductase genetic 1 1 1 Negative Genetic
RPS19B YNL302C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
ARV1 YLR242C Cortical ER protein physical 1 1 1 Biochemical Activity
ARV1 YLR242C Cortical ER protein genetic 1 1 1 Negative Genetic
AGE2 YIL044C ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector physical 1 1 1 Biochemical Activity
KIN82 YCR091W Putative serine/threonine protein kinase genetic 1 1 1 Negative Genetic
GPI12 YMR281W ER membrane protein involved in the second step of GPI anchor assembly genetic 1 1 1 Negative Genetic
EMA35 YCR100C Protein involved in protein sorting genetic 1 1 1 Negative Genetic
PTK2 YJR059W Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
PHO91 YNR013C Low-affinity vacuolar phosphate transporter physical 1 1 1 Biochemical Activity
NMT1 YLR195C N-myristoyl transferase genetic 1 1 1 Negative Genetic
POX1 YGL205W Fatty-acyl coenzyme A oxidase genetic 1 1 1 Positive Genetic
DGR2 YKL121W Protein of unknown function physical 1 1 1 Biochemical Activity
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
PIB2 YGL023C Phosphatidylinositol 3-phosphate binding protein physical 1 1 1 Biochemical Activity
SMY1 YKL079W Kinesin-like myosin passenger-protein physical 1 1 1 Biochemical Activity
NEJ1 YLR265C DNA end-binding protein required for nonhomologous end joining (NHEJ) physical 1 1 1 Biochemical Activity
RUD3 YOR216C Golgi matrix protein physical 1 1 1 Biochemical Activity
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Negative Genetic
PGA2 YNL149C Essential protein required for maturation of Gas1p and Pho8p genetic 1 1 1 Negative Genetic
SET5 YHR207C Methyltransferase involved in methylation of histone H4 Lys5, -8, -12 physical 1 1 1 Reconstituted Complex
MTG2 YHR168W Putative GTPase genetic 1 1 1 Negative Genetic
SGE1 YPR198W Plasma membrane multidrug transporter genetic 1 1 1 Dosage Rescue
CYT1 YOR065W Cytochrome c1 genetic 1 1 1 Negative Genetic
POT1 YIL160C 3-ketoacyl-CoA thiolase with broad chain length specificity physical 1 1 1 Reconstituted Complex
POT1 YIL160C 3-ketoacyl-CoA thiolase with broad chain length specificity genetic 1 1 1 Negative Genetic
MRPL49 YJL096W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
CDC50 YCR094W Endosomal protein that interacts with phospholipid flippase Drs2p genetic 1 1 1 Negative Genetic
GIS1 YDR096W Histone demethylase and transcription factor physical 1 1 1 Affinity Capture-MS
GIS1 YDR096W Histone demethylase and transcription factor genetic 1 1 1 Dosage Rescue
RSF1 YMR030W Protein required for respiratory growth genetic 1 1 1 Positive Genetic
ASI2 YNL159C Subunit of the inner nuclear membrane Asi ubiquitin ligase complex genetic 1 1 1 Positive Genetic
CHS2 YBR038W Chitin synthase II genetic 1 1 1 Negative Genetic
PDR3 YBL005W Transcriptional activator of the pleiotropic drug resistance network physical 1 1 1 Two-hybrid
HXT2 YMR011W High-affinity glucose transporter of the major facilitator superfamily genetic 1 1 1 Dosage Rescue
HXT3 YDR345C Low affinity glucose transporter of the major facilitator superfamily genetic 1 1 1 Dosage Rescue
RER2 YBR002C Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1 genetic 1 1 1 Negative Genetic
HSP30 YCR021C Negative regulator of the H(+)-ATPase Pma1p genetic 1 1 1 Phenotypic Suppression
BAP2 YBR068C High-affinity leucine permease genetic 1 1 1 Negative Genetic
ALG14 YBR070C Component of UDP-GlcNAc transferase genetic 1 1 1 Negative Genetic
DPP1 YDR284C Diacylglycerol pyrophosphate (DGPP) phosphatase genetic 1 1 1 Positive Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Negative Genetic
HER2 YMR293C Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex genetic 1 1 1 Negative Genetic
GPI13 YLL031C ER membrane localized phosphoryltransferase genetic 1 1 1 Negative Genetic
CDS1 YBR029C Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase) genetic 1 1 1 Negative Genetic
PET18 YCR020C Protein of unknown function genetic 1 1 1 Negative Genetic
RMR1 YGL250W Protein required for meiotic recombination and gene conversion genetic 1 1 1 Negative Genetic
MSN1 YOL116W Transcriptional activator genetic 1 1 1 Dosage Rescue
ALG2 YGL065C Mannosyltransferase in the N-linked glycosylation pathway genetic 1 1 1 Negative Genetic
RPE1 YJL121C D-ribulose-5-phosphate 3-epimerase genetic 1 1 1 Negative Genetic
MLO127 YJR039W Mitochondrial protein of unknown function genetic 1 1 1 Phenotypic Suppression
NFU1 YKL040C Protein involved in Fe-S cluster transfer to mitochondrial clients genetic 1 1 1 Negative Genetic
AVL9 YLR114C Conserved protein involved in exocytic transport from the Golgi genetic 1 1 1 Positive Genetic
ALG9 YNL219C Mannosyltransferase, involved in N-linked glycosylation genetic 1 1 1 Negative Genetic
EDC1 YGL222C RNA-binding protein that activates mRNA decapping directly genetic 1 1 1 Positive Genetic
DAN4 YJR151C Cell wall mannoprotein genetic 1 1 1 Negative Genetic
ATG41 YPL250C Protein of unknown function genetic 1 1 1 Negative Genetic
SMP3 YOR149C Alpha 1,2-mannosyltransferase genetic 1 1 1 Negative Genetic
GIS3 YLR094C Protein of unknown function genetic 1 1 1 Dosage Rescue
PUN1 YLR414C Plasma membrane protein with a role in cell wall integrity genetic 1 1 1 Negative Genetic
QCR9 YGR183C Subunit 9 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Negative Genetic
RSB1 YOR049C Sphingoid long-chain base (LCB) efflux transporter genetic 1 1 1 Negative Genetic
IFM1 YOL023W Mitochondrial translation initiation factor 2 genetic 1 1 1 Negative Genetic
RPO41 YFL036W Mitochondrial RNA polymerase genetic 1 1 1 Negative Genetic
CCC2 YDR270W Cu(+2)-transporting P-type ATPase genetic 1 1 1 Negative Genetic
NAT4 YMR069W N alpha-acetyl-transferase genetic 1 1 1 Negative Genetic
MPC1 YGL080W Highly conserved subunit of mitochondrial pyruvate carrier (MPC) genetic 1 1 1 Synthetic Growth Defect
CMC1 YKL137W Copper-binding protein of the mitochondrial intermembrane space genetic 1 1 1 Negative Genetic
GPI10 YGL142C Integral membrane protein involved in GPI anchor synthesis genetic 1 1 1 Negative Genetic
GPI15 YNL038W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
CPR8 YNR028W Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Negative Genetic
APS3 YJL024C Small subunit of the clathrin-associated adaptor complex AP-3 genetic 1 1 1 Negative Genetic
GMC2 YLR445W Protein involved in meiotic crossing over genetic 1 1 1 Negative Genetic
POR2 YIL114C Putative mitochondrial porin (voltage-dependent anion channel) physical 1 1 1 Affinity Capture-Western
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
SHM1 YBR263W Mitochondrial serine hydroxymethyltransferase genetic 1 1 1 Negative Genetic
MFM1 YPL060W Mitochondrial inner membrane magnesium transporter genetic 1 1 1 Negative Genetic
AIM33 YML087C Protein of unknown function, highly conserved across species genetic 1 1 1 Negative Genetic
PTH1 YHR189W One of two mitochondrially-localized peptidyl-tRNA hydrolases physical 1 1 1 Reconstituted Complex
PTH1 YHR189W One of two mitochondrially-localized peptidyl-tRNA hydrolases genetic 1 1 1 Negative Genetic
RIB2 YOL066C Bifunctional DRAP deaminase tRNA:pseudouridine synthase physical 1 1 1 Reconstituted Complex
PXP2 YJR111C Peroxisomal matrix protein with naturally active promoter physical 1 1 1 Reconstituted Complex
RCF1 YML030W Cytochrome c oxidase subunit genetic 1 1 1 Negative Genetic
PGA3 YML125C Putative cytochrome b5 reductase, localized to the plasma membrane genetic 1 1 1 Negative Genetic
OCT1 YKL134C Mitochondrial intermediate peptidase genetic 1 1 1 Negative Genetic
SEC12 YNR026C Guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Negative Genetic
PET117 YER058W Assembly factor that couples heme a synthesis to complex IV assembly genetic 1 1 1 Negative Genetic
MME1 YMR166C Transporter of the mitochondrial inner membrane that exports magnesium genetic 1 1 1 Dosage Growth Defect
MSC6 YOR354C Multicopy suppressor of HER2 involved in mitochondrial translation genetic 1 1 1 Negative Genetic
RML2 YEL050C Mitochondrial ribosomal protein of the large subunit (L2) genetic 1 1 1 Negative Genetic
HEM4 YOR278W Uroporphyrinogen III synthase genetic 1 1 1 Negative Genetic
RSM26 YJR101W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
FYV5 YCL058C De novo-originated gene from non-coding sequence physical 1 1 1 Affinity Capture-Western
LEU5 YHR002W Mitochondrial carrier protein genetic 1 1 1 Negative Genetic
PPM2 YOL141W AdoMet-dependent tRNA methyltransferase genetic 1 1 1 Negative Genetic
PHM7 YOL084W Protein of unknown function genetic 1 1 1 Negative Genetic
LDB16 YCL005W Protein involved in lipid droplet (LD) assembly genetic 1 1 1 Negative Genetic
ADF1 YCL058W-A Transcriptional repressor encoded by the FYV5 antisense strand genetic 1 1 1 Negative Genetic
PZF1 YPR186C Transcription factor IIIA (TFIIIA) genetic 1 1 1 Negative Genetic