Standard name Systematic name Name description Description
PLC1 YPL268W Phospholipase C Phospholipase C; hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate the signaling molecules inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in regulating many cellular processes; Plc1p and inositol polyphosphates are required for acetyl-CoA homeostasis which regulates global histone acetylation
Visualize the interactome of PLC1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data low signal

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
PLC1 3 0 0 3 0

Enzyme information

Catalyzed reactions in Yeast8
r_3082 (PI 4,5-P2 phospholipase C (1-16:0, 2-16:1), cytoplasm), r_3088 (PI 4,5-P2 phospholipase C (1-18:0, 2-18:1), cytoplasm), r_3094 (PI 4,5-P2 phospholipase C (1-16:0, 2-18:1), nucleus), r_3085 (PI 4,5-P2 phospholipase C (1-18:1, 2-16:1), cytoplasm), r_3091 (PI 4,5-P2 phospholipase C (1-16:1, 2-16:1), nucleus), r_3097 (PI 4,5-P2 phospholipase C (1-18:1, 2-18:1), nucleus), r_3083 (PI 4,5-P2 phospholipase C (1-16:1, 2-16:1), cytoplasm), r_3089 (PI 4,5-P2 phospholipase C (1-18:1, 2-18:1), cytoplasm), r_3086 (PI 4,5-P2 phospholipase C (1-16:0, 2-18:1), cytoplasm), r_3092 (PI 4,5-P2 phospholipase C (1-18:0, 2-16:1), nucleus), r_3095 (PI 4,5-P2 phospholipase C (1-16:1, 2-18:1), nucleus), r_3090 (PI 4,5-P2 phospholipase C (1-16:0, 2-16:1), nucleus), r_3096 (PI 4,5-P2 phospholipase C (1-18:0, 2-18:1), nucleus), r_3093 (PI 4,5-P2 phospholipase C (1-18:1, 2-16:1), nucleus), r_3084 (PI 4,5-P2 phospholipase C (1-18:0, 2-16:1), cytoplasm), r_3087 (PI 4,5-P2 phospholipase C (1-16:1, 2-18:1), cytoplasm)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 3 2 2 Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression
YCK1 YHR135C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform genetic 3 3 1 Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement
YCK2 YNL154C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform genetic 3 3 1 Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 2 2 2 Phenotypic Enhancement, Positive Genetic
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 2 2 2 Phenotypic Suppression, Synthetic Rescue
SCH9 YHR205W AGC family protein kinase genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
CBF2 YGR140W Essential kinetochore protein genetic 2 2 2 Dosage Rescue, Synthetic Lethality
ARG82 YDR173C Inositol polyphosphate multikinase (IPMK) genetic 2 2 2 Phenotypic Enhancement, Phenotypic Suppression
INP53 YOR109W Polyphosphatidylinositol phosphatase genetic 2 2 2 Positive Genetic, Negative Genetic
ACC1 YNR016C Acetyl-CoA carboxylase, biotin containing enzyme genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 2 2 1 Phenotypic Suppression, Phenotypic Enhancement
MED2 YDL005C Subunit of the RNA polymerase II mediator complex genetic 2 2 1 Phenotypic Suppression, Phenotypic Enhancement
PHO81 YGR233C Cyclin-dependent kinase (CDK) inhibitor genetic 2 2 1 Dosage Rescue, Phenotypic Enhancement
SGD1 YLR336C Essential nuclear protein physical 2 2 1 Affinity Capture-Western, Two-hybrid
SGD1 YLR336C Essential nuclear protein genetic 2 2 1 Dosage Rescue, Synthetic Growth Defect
TOR2 YKL203C PIK-related protein kinase and rapamycin target physical 2 2 1 Two-hybrid, Affinity Capture-Western
SPL2 YHR136C Protein with similarity to cyclin-dependent kinase inhibitors genetic 2 2 1 Dosage Rescue, Phenotypic Enhancement
RSC2 YLR357W Component of the RSC chromatin remodeling complex genetic 2 2 1 Phenotypic Enhancement, Synthetic Growth Defect
SFH1 YLR321C Component of the RSC chromatin remodeling complex genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
STH1 YIL126W ATPase component of the RSC chromatin remodeling complex genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
CBF2 YGR140W Essential kinetochore protein physical 2 2 1 Two-hybrid, Affinity Capture-Western
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP5 YIR018W Basic leucine zipper (bZIP) iron-sensing transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Synthetic Lethality
ADH1 YOL086C Alcohol dehydrogenase genetic 1 1 1 Positive Genetic
ARL1 YBR164C Soluble GTPase with a role in regulation of membrane traffic genetic 1 1 1 Negative Genetic
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
CAF130 YGR134W Subunit of the CCR4-NOT transcriptional regulatory complex physical 1 1 1 Affinity Capture-MS
BOI2 YER114C Protein involved in polar growth genetic 1 1 1 Negative Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 1 1 1 Negative Genetic
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase genetic 1 1 1 Phenotypic Suppression
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
LSM7 YNL147W Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 1 1 1 Negative Genetic
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control genetic 1 1 1 Negative Genetic
GIN4 YDR507C Protein kinase involved in bud growth and assembly of the septin ring genetic 1 1 1 Negative Genetic
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Growth Defect
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Synthetic Lethality
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
ADO1 YJR105W Adenosine kinase genetic 1 1 1 Positive Genetic
ATG17 YLR423C Scaffold protein responsible for phagophore assembly site organization physical 1 1 1 Two-hybrid
BUB2 YMR055C Mitotic exit network regulator genetic 1 1 1 Synthetic Growth Defect
CYC8 YBR112C General transcriptional co-repressor genetic 1 1 1 Negative Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
GPA2 YER020W Nucleotide binding alpha subunit of the heterotrimeric G protein physical 1 1 1 Affinity Capture-Western
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation genetic 1 1 1 Synthetic Lethality
MKK2 YPL140C MAPKK involved in the protein kinase C signaling pathway genetic 1 1 1 Negative Genetic
OPY1 YBR129C Protein of unknown function genetic 1 1 1 Negative Genetic
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 1 1 1 Negative Genetic
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 1 1 1 Synthetic Growth Defect
IST3 YIR005W Component of the U2 snRNP genetic 1 1 1 Negative Genetic
ATG1 YGL180W Protein serine/threonine kinase physical 1 1 1 Biochemical Activity
CLN3 YAL040C G1 cyclin involved in cell cycle progression genetic 1 1 1 Negative Genetic
MAD2 YJL030W Component of the spindle-assembly checkpoint complex genetic 1 1 1 Synthetic Lethality
CLG1 YGL215W Cyclin-like protein that interacts with Pho85p genetic 1 1 1 Negative Genetic
JLP1 YLL057C Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase genetic 1 1 1 Positive Genetic
CEP3 YMR168C Essential kinetochore protein physical 1 1 1 Two-hybrid
CEP3 YMR168C Essential kinetochore protein genetic 1 1 1 Synthetic Growth Defect
ELP3 YPL086C Subunit of Elongator complex genetic 1 1 1 Positive Genetic
MIF2 YKL089W Centromeric CDEIII region binding protein genetic 1 1 1 Synthetic Lethality
TOR2 YKL203C PIK-related protein kinase and rapamycin target genetic 1 1 1 Dosage Rescue
VAC14 YLR386W Enzyme regulator physical 1 1 1 Two-hybrid
WHI3 YNL197C RNA binding protein that modulates mRNA stability physical 1 1 1 Affinity Capture-RNA
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
STE11 YLR362W Signal transducing MEK kinase genetic 1 1 1 Dosage Rescue
TPK2 YPL203W cAMP-dependent protein kinase catalytic subunit genetic 1 1 1 Dosage Rescue
SKP1 YDR328C Evolutionarily conserved kinetochore protein genetic 1 1 1 Synthetic Lethality
SRB8 YCR081W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Phenotypic Suppression
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 1 1 1 Phenotypic Suppression
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 1 1 1 Negative Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 1 1 1 Positive Genetic
SOL2 YCR073W-A Protein with a possible role in tRNA export genetic 1 1 1 Negative Genetic
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 1 1 1 Negative Genetic
SNF1 YDR477W AMP-activated S/T protein kinase genetic 1 1 1 Negative Genetic
SYS1 YJL004C Integral membrane protein of the Golgi genetic 1 1 1 Negative Genetic
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Positive Genetic
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 1 1 1 Positive Genetic
TUB3 YML124C Alpha-tubulin genetic 1 1 1 Negative Genetic
RPS1B YML063W Ribosomal protein of the small (40S) subunit genetic 1 1 1 Synthetic Growth Defect
PUT2 YHR037W Delta-1-pyrroline-5-carboxylate dehydrogenase genetic 1 1 1 Negative Genetic
TKL1 YPR074C Transketolase genetic 1 1 1 Negative Genetic
SDH9 YJL045W Minor succinate dehydrogenase isozyme genetic 1 1 1 Negative Genetic
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Synthetic Lethality
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Synthetic Lethality
SPT7 YBR081C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Synthetic Lethality
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 1 1 1 Synthetic Lethality
SPT20 YOL148C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Synthetic Lethality
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Synthetic Lethality
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 1 1 1 Synthetic Growth Defect
MTH1 YDR277C Negative regulator of the glucose-sensing signal transduction pathway genetic 1 1 1 Phenotypic Suppression
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Positive Genetic
MUD2 YKL074C Protein involved in early pre-mRNA splicing genetic 1 1 1 Negative Genetic
FBP26 YJL155C Fructose-2,6-bisphosphatase, required for glucose metabolism genetic 1 1 1 Negative Genetic
MON1 YGL124C Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) physical 1 1 1 Two-hybrid
ARK1 YNL020C Ser/Thr protein kinase genetic 1 1 1 Negative Genetic
NUP42 YDR192C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Synthetic Growth Defect
INP51 YIL002C Phosphatidylinositol 4,5-bisphosphate 5-phosphatase genetic 1 1 1 Phenotypic Enhancement
HXK1 YFR053C Hexokinase isoenzyme 1 genetic 1 1 1 Negative Genetic
GUT1 YHL032C Glycerol kinase genetic 1 1 1 Negative Genetic
MHO1 YJR008W Protein of unknown function genetic 1 1 1 Synthetic Lethality
ARG7 YMR062C Mitochondrial ornithine acetyltransferase genetic 1 1 1 Negative Genetic