Standard name Systematic name Name description Description
INP53 YOR109W Polyphosphatidylinositol phosphatase Polyphosphatidylinositol phosphatase; dephosphorylates multiple phosphatidylinositol phosphates; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains; INP53 has a paralog, INP52, that arose from the whole genome duplication
Visualize the interactome of INP53
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cort. Patches 0.152 0.181 0.181
Cytoplasm 0.061 0.323 0.131
ER 0.121 0.155 0.138
Golgi 0.667 0.350 0.113
Vac/Vac Memb 0.121 0.071 NaN
Mito NaN 0.115 0.594
Bud NaN NaN 0.081

GFP localization & abundance

GFP localization GFP abundance
punctate composite 1520

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
INP53 2 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_3157 (PI 4-P phosphatase (1-16:1, 2-18:1), cytoplasm), r_3206 (PI 4,5-P2 phosphatase (1-18:0, 2-18:1), cytoplasm), r_3201 (PI 4,5-P2 phosphatase (1-16:1, 2-16:1), cytoplasm), r_3114 (PI 3-P phosphatase (1-18:0, 2-16:1), cell envelope), r_3152 (PI 4-P phosphatase (1-16:0, 2-16:1), cytoplasm), r_3196 (PI 4,5-P2 phosphatase (1-16:0, 2-18:1), cell envelope), r_3180 (PI 3,5-P2 phosphatase (1-16:0, 2-18:1), cell envelope), r_3158 (PI 4-P phosphatase (1-18:0, 2-18:1), cytoplasm), r_3207 (PI 4,5-P2 phosphatase (1-18:1, 2-18:1), cytoplasm), r_3202 (PI 4,5-P2 phosphatase (1-18:0, 2-16:1), cytoplasm), r_3115 (PI 3-P phosphatase (1-18:1, 2-16:1), cell envelope), r_3153 (PI 4-P phosphatase (1-16:1, 2-16:1), cytoplasm), r_3197 (PI 4,5-P2 phosphatase (1-16:1, 2-18:1), cell envelope), r_3179 (PI 3,5-P2 phosphatase (1-18:1, 2-16:1), cell envelope), r_3181 (PI 3,5-P2 phosphatase (1-16:1, 2-18:1), cell envelope), r_3159 (PI 4-P phosphatase (1-18:1, 2-18:1), cytoplasm), r_3176 (PI 3,5-P2 phosphatase (1-16:0, 2-16:1), cell envelope), r_3116 (PI 3-P phosphatase (1-16:0, 2-18:1), cell envelope), r_3154 (PI 4-P phosphatase (1-18:0, 2-16:1), cytoplasm), r_3203 (PI 4,5-P2 phosphatase (1-18:1, 2-16:1), cytoplasm), r_3198 (PI 4,5-P2 phosphatase (1-18:0, 2-18:1), cell envelope), r_3182 (PI 3,5-P2 phosphatase (1-18:0, 2-18:1), cell envelope), r_3177 (PI 3,5-P2 phosphatase (1-16:1, 2-16:1), cell envelope), r_3117 (PI 3-P phosphatase (1-16:1, 2-18:1), cell envelope), r_3155 (PI 4-P phosphatase (1-18:1, 2-16:1), cytoplasm), r_3204 (PI 4,5-P2 phosphatase (1-16:0, 2-18:1), cytoplasm), r_3199 (PI 4,5-P2 phosphatase (1-18:1, 2-18:1), cell envelope), r_3183 (PI 3,5-P2 phosphatase (1-18:1, 2-18:1), cell envelope), r_3112 (PI 3-P phosphatase (1-16:0, 2-16:1), cell envelope), r_3178 (PI 3,5-P2 phosphatase (1-18:0, 2-16:1), cell envelope), r_3118 (PI 3-P phosphatase (1-18:0, 2-18:1), cell envelope), r_3156 (PI 4-P phosphatase (1-16:0, 2-18:1), cytoplasm), r_3205 (PI 4,5-P2 phosphatase (1-16:1, 2-18:1), cytoplasm), r_3184 (PI 3,5-P2 phosphatase (1-16:0, 2-16:1), cytoplasm), r_3200 (PI 4,5-P2 phosphatase (1-16:0, 2-16:1), cytoplasm), r_3113 (PI 3-P phosphatase (1-16:1, 2-16:1), cell envelope), r_3119 (PI 3-P phosphatase (1-18:1, 2-18:1), cell envelope), r_3146 (PI 4-P phosphatase (1-18:0, 2-16:1), cell envelope), r_3185 (PI 3,5-P2 phosphatase (1-16:1, 2-16:1), cytoplasm), r_3191 (PI 3,5-P2 phosphatase (1-18:1, 2-18:1), cytoplasm), r_3125 (PI 3-P phosphatase (1-16:1, 2-18:1), cytoplasm), r_3120 (PI 3-P phosphatase (1-16:0, 2-16:1), cytoplasm), r_3147 (PI 4-P phosphatase (1-18:1, 2-16:1), cell envelope), r_3186 (PI 3,5-P2 phosphatase (1-18:0, 2-16:1), cytoplasm), r_3121 (PI 3-P phosphatase (1-16:1, 2-16:1), cytoplasm), r_3192 (PI 4,5-P2 phosphatase (1-16:0, 2-16:1), cell envelope), r_3124 (PI 3-P phosphatase (1-16:0, 2-18:1), cytoplasm), r_3126 (PI 3-P phosphatase (1-18:0, 2-18:1), cytoplasm), r_3148 (PI 4-P phosphatase (1-16:0, 2-18:1), cell envelope), r_3190 (PI 3,5-P2 phosphatase (1-18:0, 2-18:1), cytoplasm), r_3187 (PI 3,5-P2 phosphatase (1-18:1, 2-16:1), cytoplasm), r_3193 (PI 4,5-P2 phosphatase (1-16:1, 2-16:1), cell envelope), r_3127 (PI 3-P phosphatase (1-18:1, 2-18:1), cytoplasm), r_3149 (PI 4-P phosphatase (1-16:1, 2-18:1), cell envelope), r_3122 (PI 3-P phosphatase (1-18:0, 2-16:1), cytoplasm), r_3188 (PI 3,5-P2 phosphatase (1-16:0, 2-18:1), cytoplasm), r_3144 (PI 4-P phosphatase (1-16:0, 2-16:1), cell envelope), r_3194 (PI 4,5-P2 phosphatase (1-18:0, 2-16:1), cell envelope), r_3150 (PI 4-P phosphatase (1-18:0, 2-18:1), cell envelope), r_3123 (PI 3-P phosphatase (1-18:1, 2-16:1), cytoplasm), r_3189 (PI 3,5-P2 phosphatase (1-16:1, 2-18:1), cytoplasm), r_3145 (PI 4-P phosphatase (1-16:1, 2-16:1), cell envelope), r_3195 (PI 4,5-P2 phosphatase (1-18:1, 2-16:1), cell envelope), r_3151 (PI 4-P phosphatase (1-18:1, 2-18:1), cell envelope)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
INP52 YNL106C Polyphosphatidylinositol phosphatase genetic 10 4 9 Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 5 4 5 Dosage Rescue, Phenotypic Enhancement, Negative Genetic, Synthetic Lethality, Negative Genetic
GGA2 YHR108W Protein that regulates Arf1p, Arf2p to facilitate Golgi trafficking genetic 5 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
YPT6 YLR262C Rab family GTPase genetic 5 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
THR4 YCR053W Threonine synthase genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
KRE1 YNL322C Cell wall glycoprotein involved in beta-glucan assembly genetic 4 2 4 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
INP51 YIL002C Phosphatidylinositol 4,5-bisphosphate 5-phosphatase genetic 4 2 4 Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality
GET1 YGL020C Subunit of the GET complex genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
COG6 YNL041C Component of the conserved oligomeric Golgi complex genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
COG5 YNL051W Component of the conserved oligomeric Golgi complex genetic 4 2 3 Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic
RGP1 YDR137W Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) genetic 4 2 3 Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Negative Genetic
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 4 2 3 Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Negative Genetic
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
COG8 YML071C Component of the conserved oligomeric Golgi complex genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
VPS13 YLL040C Lipid transport protein involved in prospore membrane morphogenesis genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
AGE2 YIL044C ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CHC1 YGL206C Clathrin heavy chain physical 3 2 3 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
GLO3 YER122C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 3 2 3 Dosage Rescue, Negative Genetic, Negative Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
YMR1 YJR110W Phosphatidylinositol 3-phosphate (PI3P) phosphatase genetic 3 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic
YPT1 YFL038C Rab family GTPase genetic 3 2 3 Dosage Rescue, Negative Genetic, Negative Genetic
ATG21 YPL100W Phosphoinositide binding protein genetic 3 2 3 Negative Genetic, Dosage Rescue, Negative Genetic
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
HOM3 YER052C Aspartate kinase (L-aspartate 4-P-transferase) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ENT3 YJR125C Protein containing an N-terminal epsin-like domain genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
COG7 YGL005C Component of the conserved oligomeric Golgi complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SER2 YGR208W Phosphoserine phosphatase of the phosphoglycerate pathway genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
GDA1 YEL042W Guanosine diphosphatase located in the Golgi genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
BSP1 YPR171W Adapter that links synaptojanins to the cortical actin cytoskeleton physical 3 2 2 Affinity Capture-Western, Two-hybrid, Affinity Capture-Western
PDI1 YCL043C Protein disulfide isomerase genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 3 2 2 Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement
ROT2 YBR229C Glucosidase II catalytic subunit genetic 3 2 2 Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic
TLG2 YOL018C Syntaxin-like t-SNARE genetic 3 2 2 Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic
GCS1 YDL226C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 3 2 2 Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VPS51 YKR020W Component of the GARP (Golgi-associated retrograde protein) complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VTI1 YMR197C Protein involved in cis-Golgi membrane traffic genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 2 2 2 Positive Genetic, Negative Genetic
BZZ1 YHR114W SH3 domain protein implicated in regulating actin polymerization physical 2 2 2 Two-hybrid, Affinity Capture-Western
SLA1 YBL007C Cytoskeletal protein binding protein physical 2 2 2 Two-hybrid, Affinity Capture-Western
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 2 2 2 Positive Genetic, Negative Genetic
PLC1 YPL268W Phospholipase C genetic 2 2 2 Positive Genetic, Negative Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 2 2 2 Dosage Rescue, Positive Genetic
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 2 2 2 Negative Genetic, Positive Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 2 1 2 Negative Genetic, Negative Genetic
HSE1 YHL002W Subunit of the endosomal Vps27p-Hse1p complex genetic 2 1 2 Negative Genetic, Negative Genetic
GET2 YER083C Subunit of the GET complex genetic 2 1 2 Negative Genetic, Negative Genetic
FAR3 YMR052W Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex genetic 2 1 2 Negative Genetic, Negative Genetic
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 2 1 2 Negative Genetic, Negative Genetic
VMA8 YEL051W Subunit D of the V1 peripheral membrane domain of V-ATPase genetic 2 1 2 Negative Genetic, Negative Genetic
SEH1 YGL100W Subunit of the Nup84 nuclear pore and SEACAT subcomplexes genetic 2 1 2 Negative Genetic, Negative Genetic
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 2 1 2 Negative Genetic, Negative Genetic
SWI3 YJL176C Subunit of the SWI/SNF chromatin remodeling complex genetic 2 1 2 Positive Genetic, Positive Genetic
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway genetic 2 1 2 Negative Genetic, Negative Genetic
KES1 YPL145C Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger genetic 2 1 2 Negative Genetic, Negative Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 2 1 2 Positive Genetic, Positive Genetic
SRN2 YLR119W Component of the ESCRT-I complex genetic 2 1 2 Negative Genetic, Negative Genetic
VPS29 YHR012W Subunit of the membrane-associated retromer complex genetic 2 1 2 Negative Genetic, Negative Genetic
PEP8 YJL053W Vacuolar protein component of the retromer genetic 2 1 2 Negative Genetic, Negative Genetic
RET2 YFR051C Delta subunit of the coatomer complex (COPI) genetic 2 1 2 Negative Genetic, Negative Genetic
SYS1 YJL004C Integral membrane protein of the Golgi genetic 2 1 2 Negative Genetic, Negative Genetic
AUR1 YKL004W Phosphatidylinositol:ceramide phosphoinositol transferase genetic 2 1 2 Negative Genetic, Negative Genetic
DER1 YBR201W ER membrane protein that promotes export of misfolded polypeptides genetic 2 1 2 Negative Genetic, Negative Genetic
ILM1 YJR118C Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
CMP2 YML057W Calcineurin A physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
ARL1 YBR164C Soluble GTPase with a role in regulation of membrane traffic genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
ERP1 YAR002C-A Member of the p24 family involved in ER to Golgi transport genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
GET3 YDL100C Guanine nucleotide exchange factor for Gpa1p genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
TRS85 YDR108W Component of transport protein particle (TRAPP) complex III genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
USA1 YML029W Scaffold subunit of the Hrd1p ubiquitin ligase genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
VPS9 YML097C Guanine nucleotide exchange factor (GEF) and ubiquitin receptor genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
RER1 YCL001W Protein involved in retention of membrane proteins genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
KEX2 YNL238W Kexin, a subtilisin-like protease (proprotein convertase) genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
SWC5 YBR231C Component of the SWR1 complex genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
RUD3 YOR216C Golgi matrix protein genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer genetic 2 1 1 Negative Genetic, Negative Genetic
CCW12 YLR110C Cell wall mannoprotein genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
CNE1 YAL058W Calnexin genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit regulation 1 1 1 quantitative mass spectrometry evidence
YAP5 YIR018W Basic leucine zipper (bZIP) iron-sensing transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CAD1 YDR423C AP-1-like basic leucine zipper (bZIP) transcriptional activator regulation 1 1 1 DNA to cDNA expression microarray evidence
DSN1 YIR010W Essential component of the outer kinetochore MIND complex physical 1 1 1 Affinity Capture-MS
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p genetic 1 1 1 Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
APL2 YKL135C Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex physical 1 1 1 PCA
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 1 1 1 Positive Genetic
BUD14 YAR014C Protein involved in bud-site selection genetic 1 1 1 Negative Genetic
BNI1 YNL271C Formin genetic 1 1 1 Synthetic Growth Defect
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 1 1 1 Positive Genetic
BUD31 YCR063W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Negative Genetic
CHC1 YGL206C Clathrin heavy chain genetic 1 1 1 Synthetic Growth Defect
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Negative Genetic
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Negative Genetic
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase genetic 1 1 1 Negative Genetic
GGA2 YHR108W Protein that regulates Arf1p, Arf2p to facilitate Golgi trafficking physical 1 1 1 PCA
ERV25 YML012W Member of the p24 family involved in ER to Golgi transport genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
CLU1 YMR012W Subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Affinity Capture-MS
END3 YNL084C EH domain-containing protein involved in endocytosis genetic 1 1 1 Negative Genetic
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Negative Genetic
ANP1 YEL036C Subunit of the alpha-1,6 mannosyltransferase complex genetic 1 1 1 Positive Genetic
BRO1 YPL084W Cytoplasmic class E vacuolar protein sorting (VPS) factor genetic 1 1 1 Positive Genetic
FUN19 YAL034C Non-essential protein of unknown function genetic 1 1 1 Negative Genetic
DRS2 YAL026C Trans-golgi network aminophospholipid translocase (flippase) genetic 1 1 1 Negative Genetic
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
ARF1 YDL192W ADP-ribosylation factor genetic 1 1 1 Negative Genetic
DDC1 YPL194W DNA damage checkpoint protein genetic 1 1 1 Negative Genetic
DSS1 YMR287C 3'-5' exoribonuclease genetic 1 1 1 Positive Genetic
ERG1 YGR175C Squalene epoxidase genetic 1 1 1 Negative Genetic
IMD4 YML056C Inosine monophosphate dehydrogenase genetic 1 1 1 Negative Genetic
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription genetic 1 1 1 Positive Genetic
AFR1 YDR085C Protein required for pheromone-induced projection (shmoo) formation genetic 1 1 1 Negative Genetic
HAP3 YBL021C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Negative Genetic
HOM2 YDR158W Aspartic beta semi-aldehyde dehydrogenase genetic 1 1 1 Negative Genetic
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Negative Genetic
FMP48 YGR052W Putative protein of unknown function genetic 1 1 1 Positive Genetic
APL4 YPR029C Gamma-adaptin physical 1 1 1 PCA
FMN1 YDR236C Riboflavin kinase, produces riboflavin monophosphate (FMN) genetic 1 1 1 Negative Genetic
GNA1 YFL017C Glucosamine-6-phosphate acetyltransferase genetic 1 1 1 Negative Genetic
AIM18 YHR198C Protein of unknown function genetic 1 1 1 Negative Genetic
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 1 1 1 Negative Genetic
BOS1 YLR078C v-SNARE (vesicle specific SNAP receptor) genetic 1 1 1 Negative Genetic
ELP4 YPL101W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Dosage Rescue
IES3 YLR052W Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Positive Genetic
CLC1 YGR167W Clathrin light chain genetic 1 1 1 Negative Genetic
HXK2 YGL253W Hexokinase isoenzyme 2 genetic 1 1 1 Negative Genetic
GOS1 YHL031C v-SNARE protein involved in Golgi transport genetic 1 1 1 Negative Genetic
GAP1 YKR039W General amino acid permease genetic 1 1 1 Negative Genetic
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Positive Genetic
CHS3 YBR023C Chitin synthase III genetic 1 1 1 Negative Genetic
ERG25 YGR060W C-4 methyl sterol oxidase genetic 1 1 1 Positive Genetic
GSY2 YLR258W Glycogen synthase genetic 1 1 1 Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein physical 1 1 1 Two-hybrid
TVP15 YDR100W Integral membrane protein physical 1 1 1 Two-hybrid
LSB3 YFR024C-A Protein containing a C-terminal SH3 domain physical 1 1 1 Two-hybrid
YSC84 YHR016C Actin-binding protein physical 1 1 1 Two-hybrid
SLA1 YBL007C Cytoskeletal protein binding protein genetic 1 1 1 Negative Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 1 1 1 Affinity Capture-MS
RGD1 YBR260C GTPase-activating protein (RhoGAP) for Rho3p and Rho4p physical 1 1 1 Affinity Capture-MS
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
RVS167 YDR388W Calmodulin-binding actin-associated protein physical 1 1 1 Affinity Capture-Western
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 1 1 1 Positive Genetic
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
RPB3 YIL021W RNA polymerase II third largest subunit B44 physical 1 1 1 Affinity Capture-MS
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Synthetic Rescue
SRO7 YPR032W Effector of Rab GTPase Sec4p genetic 1 1 1 Phenotypic Enhancement
PIK1 YNL267W Phosphatidylinositol 4-kinase genetic 1 1 1 Synthetic Lethality
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Positive Genetic
VHS1 YDR247W Cytoplasmic serine/threonine protein kinase genetic 1 1 1 Positive Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Negative Genetic
STE20 YHL007C Cdc42p-activated signal transducing kinase genetic 1 1 1 Positive Genetic
ZDS1 YMR273C Protein with a role in regulating Swe1p-dependent polarized growth genetic 1 1 1 Negative Genetic
SIT4 YDL047W Ceramide-activated, type 2A-related serine-threonine phosphatase genetic 1 1 1 Positive Genetic
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Positive Genetic
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase genetic 1 1 1 Positive Genetic
PTK2 YJR059W Serine/threonine protein kinase genetic 1 1 1 Positive Genetic
VAC14 YLR386W Enzyme regulator genetic 1 1 1 Positive Genetic
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Negative Genetic
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 1 1 1 Negative Genetic
RIA1 YNL163C Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis genetic 1 1 1 Positive Genetic
KAR2 YJL034W ATPase involved in protein import into the ER genetic 1 1 1 Positive Genetic
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Synthetic Growth Defect
VOA1 YGR106C ER protein that functions in assembly of the V0 sector of V-ATPase genetic 1 1 1 Synthetic Growth Defect
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p genetic 1 1 1 Dosage Rescue
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II genetic 1 1 1 Synthetic Rescue
SAC7 YDR389W GTPase activating protein (GAP) for Rho1p genetic 1 1 1 Dosage Rescue
MSG5 YNL053W Dual-specificity protein phosphatase genetic 1 1 1 Dosage Rescue
OSH7 YHR001W Oxysterol-binding phosphatidylserine transferase genetic 1 1 1 Dosage Rescue
ROY1 YMR258C GTPase inhibitor with similarity to F-box proteins genetic 1 1 1 Dosage Rescue
RME1 YGR044C Zinc finger protein involved in control of meiosis genetic 1 1 1 Dosage Rescue
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism genetic 1 1 1 Dosage Rescue
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone genetic 1 1 1 Dosage Rescue
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Synthetic Rescue
YPT31 YER031C Rab family GTPase genetic 1 1 1 Negative Genetic
SNC2 YOR327C Vesicle membrane receptor protein (v-SNARE) genetic 1 1 1 Negative Genetic
VPS5 YOR069W Nexin-1 homolog genetic 1 1 1 Negative Genetic
PHO84 YML123C High-affinity inorganic phosphate (Pi) transporter genetic 1 1 1 Positive Genetic
VMA2 YBR127C Subunit B of V1 peripheral membrane domain of vacuolar H+-ATPase genetic 1 1 1 Negative Genetic
NCP1 YHR042W NADP-cytochrome P450 reductase genetic 1 1 1 Negative Genetic
PXA1 YPL147W Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p genetic 1 1 1 Negative Genetic
UGP1 YKL035W UDP-glucose pyrophosphorylase (UGPase) genetic 1 1 1 Positive Genetic
LEU5 YHR002W Mitochondrial carrier protein genetic 1 1 1 Negative Genetic
SPE1 YKL184W Ornithine decarboxylase genetic 1 1 1 Positive Genetic
RBK1 YCR036W Ribokinase, phosphorylates ribose to ribose-5-phosphate genetic 1 1 1 Negative Genetic
LAT1 YNL071W Dihydrolipoamide acetyltransferase component (E2) of the PDC genetic 1 1 1 Negative Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Positive Genetic
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Negative Genetic
TEL2 YGR099W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Negative Genetic
NHX1 YDR456W Na+/H+ and K+/H+ exchanger genetic 1 1 1 Negative Genetic
VPS74 YDR372C Golgi PI4K effector, PtdIns4P sensor, and retention receptor genetic 1 1 1 Negative Genetic
VPS60 YDR486C Protein involved in late endosome to vacuole transport genetic 1 1 1 Negative Genetic
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting genetic 1 1 1 Negative Genetic
TRS130 YMR218C Component of transport protein particle (TRAPP) complex II genetic 1 1 1 Negative Genetic
SLX4 YLR135W Endonuclease involved in processing DNA genetic 1 1 1 Negative Genetic
YDR514C YDR514C Protein of unknown function that localizes to mitochondria genetic 1 1 1 Positive Genetic
SPO11 YHL022C Meiosis-specific protein required for meiotic recombination genetic 1 1 1 Positive Genetic
SRL3 YKR091W Repressor of transcription at Start genetic 1 1 1 Positive Genetic
POP7 YBR167C Subunit of RNase MRP, nuclear RNase P and telomerase genetic 1 1 1 Negative Genetic
TRS20 YBR254C Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Negative Genetic
LCB2 YDR062W Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
TLG1 YDR468C Essential t-SNARE that mediates fusion of vesicles with the late Golgi genetic 1 1 1 Negative Genetic
SED5 YLR026C cis-Golgi t-SNARE syntaxin genetic 1 1 1 Negative Genetic
SRV2 YNL138W CAP (cyclase-associated protein) genetic 1 1 1 Negative Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
SEC2 YNL272C Guanyl-nucleotide exchange factor for the small G-protein Sec4p genetic 1 1 1 Negative Genetic
SEC12 YNR026C Guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
SEC17 YBL050W Alpha-SNAP cochaperone genetic 1 1 1 Negative Genetic
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer genetic 1 1 1 Negative Genetic
YIP1 YGR172C Integral membrane protein genetic 1 1 1 Negative Genetic
SEC23 YPR181C GTPase-activating protein, stimulates the GTPase activity of Sar1p genetic 1 1 1 Negative Genetic
VPS54 YDR027C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 1 1 1 Negative Genetic
MRP1 YDR347W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
VPS52 YDR484W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
RML2 YEL050C Mitochondrial ribosomal protein of the large subunit (L2) genetic 1 1 1 Negative Genetic
SOM1 YEL059C-A Subunit of the mitochondrial inner membrane peptidase (IMP) genetic 1 1 1 Negative Genetic
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex genetic 1 1 1 Negative Genetic
RPL1B YGL135W Ribosomal 60S subunit protein L1B genetic 1 1 1 Negative Genetic
KEL2 YGR238C Protein that negatively regulates mitotic exit genetic 1 1 1 Negative Genetic
MRPL6 YHR147C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
TUS1 YLR425W Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity genetic 1 1 1 Negative Genetic
SMA2 YML066C Meiosis-specific prospore membrane protein genetic 1 1 1 Negative Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Negative Genetic
MRPL17 YNL252C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
YAR029W YAR029W Member of DUP240 gene family but contains no transmembrane domains genetic 1 1 1 Negative Genetic
PTC4 YBR125C Cytoplasmic type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
RTC2 YBR147W Putative vacuolar membrane transporter for cationic amino acids genetic 1 1 1 Negative Genetic
YCR016W YCR016W Putative protein of unknown function genetic 1 1 1 Negative Genetic
RIM1 YCR028C-A ssDNA-binding protein essential for mitochondrial genome maintenance genetic 1 1 1 Negative Genetic
MSH3 YCR092C Mismatch repair protein genetic 1 1 1 Negative Genetic
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
PPH21 YDL134C Catalytic subunit of protein phosphatase 2A, PP2A genetic 1 1 1 Negative Genetic
SAC3 YDR159W mRNA export factor genetic 1 1 1 Negative Genetic
YDR248C YDR248C Putative gluconokinase genetic 1 1 1 Negative Genetic
SWA2 YDR320C Auxilin-like protein involved in vesicular transport genetic 1 1 1 Negative Genetic
URC2 YDR520C Putative Zn(II)2Cys6 motif containing transcription factor genetic 1 1 1 Negative Genetic
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Negative Genetic
VAM7 YGL212W Vacuolar SNARE protein genetic 1 1 1 Negative Genetic
RTG2 YGL252C Sensor of mitochondrial dysfunction genetic 1 1 1 Negative Genetic
PAU11 YGL261C Putative protein of unknown function genetic 1 1 1 Negative Genetic
RTS3 YGR161C Putative component of the protein phosphatase type 2A complex genetic 1 1 1 Negative Genetic
PTH1 YHR189W One of two mitochondrially-localized peptidyl-tRNA hydrolases genetic 1 1 1 Negative Genetic
MND2 YIR025W Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
SDH9 YJL045W Minor succinate dehydrogenase isozyme genetic 1 1 1 Negative Genetic
YJL068C YJL068C Esterase that can function as an S-formylglutathione hydrolase genetic 1 1 1 Negative Genetic
RPS21B YJL136C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
PIR5 YJL160C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YJR084W YJR084W Protein that forms a complex with Thp3p genetic 1 1 1 Negative Genetic
YJR098C YJR098C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YKL075C YKL075C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YRA2 YKL214C Member of the REF (RNA and export factor binding proteins) family genetic 1 1 1 Negative Genetic
POM33 YLL023C Transmembrane nucleoporin genetic 1 1 1 Negative Genetic
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER genetic 1 1 1 Negative Genetic
TOP3 YLR234W DNA Topoisomerase III genetic 1 1 1 Negative Genetic
LIP2 YLR239C Lipoyl ligase genetic 1 1 1 Negative Genetic
SYM1 YLR251W Protein required for ethanol metabolism genetic 1 1 1 Negative Genetic
PKR1 YMR123W V-ATPase assembly factor genetic 1 1 1 Negative Genetic
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) genetic 1 1 1 Negative Genetic
PET8 YNL003C S-adenosylmethionine transporter of the mitochondrial inner membrane genetic 1 1 1 Negative Genetic
OCA2 YNL056W Protein of unknown function genetic 1 1 1 Negative Genetic
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 1 1 1 Negative Genetic
LSM7 YNL147W Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
POC4 YPL144W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 1 1 1 Negative Genetic
PRM4 YPL156C Pheromone-regulated protein proposed to be involved in mating genetic 1 1 1 Negative Genetic
MDL2 YPL270W Mitochondrial inner membrane half-type ABC transporter genetic 1 1 1 Negative Genetic
RPL43A YPR043W Ribosomal 60S subunit protein L43A genetic 1 1 1 Negative Genetic
QCR2 YPR191W Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Negative Genetic
PIL1 YGR086C Eisosome core component genetic 1 1 1 Synthetic Growth Defect
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Positive Genetic
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 1 1 1 Positive Genetic
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
SEC59 YMR013C Dolichol kinase genetic 1 1 1 Negative Genetic
VPS35 YJL154C Endosomal subunit of membrane-associated retromer complex genetic 1 1 1 Negative Genetic
VPS38 YLR360W Part of a Vps34p phosphatidylinositol 3-kinase complex genetic 1 1 1 Positive Genetic
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 1 1 1 Negative Genetic
MTC1 YJL123C Protein of unknown function that may interact with ribosomes genetic 1 1 1 Positive Genetic
STT4 YLR305C Phosphatidylinositol-4-kinase genetic 1 1 1 Negative Genetic
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 1 1 1 Negative Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Rescue
GAD1 YMR250W Glutamate decarboxylase genetic 1 1 1 Negative Genetic
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Negative Genetic
AZF1 YOR113W Zinc-finger transcription factor genetic 1 1 1 Dosage Rescue
HMRA1 YCR097W Silenced copy of a1 at HMR genetic 1 1 1 Dosage Rescue
CPR7 YJR032W Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Negative Genetic
ERV29 YGR284C Protein localized to COPII-coated vesicles genetic 1 1 1 Negative Genetic
GGA1 YDR358W Golgi-localized protein with homology to gamma-adaptin genetic 1 1 1 Synthetic Lethality
BCS1 YDR375C Protein translocase and chaperone required for Complex III assembly genetic 1 1 1 Negative Genetic
ERV14 YGL054C COPII-coated vesicle protein genetic 1 1 1 Negative Genetic
INN1 YNL152W Essential protein that associates with contractile actomyosin ring genetic 1 1 1 Negative Genetic
AIM44 YPL158C Regulator of Cdc42p and Rho1p genetic 1 1 1 Negative Genetic
BUG1 YDL099W Cis-golgi localized protein involved in ER to Golgi transport genetic 1 1 1 Negative Genetic
ERG2 YMR202W C-8 sterol isomerase genetic 1 1 1 Positive Genetic
ETR1 YBR026C 2-enoyl thioester reductase genetic 1 1 1 Negative Genetic
GPI17 YDR434W Transmembrane protein genetic 1 1 1 Negative Genetic
GUP1 YGL084C Plasma membrane protein involved in remodeling GPI anchors genetic 1 1 1 Negative Genetic
CDC50 YCR094W Endosomal protein that interacts with phospholipid flippase Drs2p genetic 1 1 1 Negative Genetic
ARF3 YOR094W Glucose-repressible ADP-ribosylation factor genetic 1 1 1 Dosage Rescue
HXT2 YMR011W High-affinity glucose transporter of the major facilitator superfamily genetic 1 1 1 Negative Genetic
ERG4 YGL012W C-24(28) sterol reductase genetic 1 1 1 Negative Genetic
ALG14 YBR070C Component of UDP-GlcNAc transferase genetic 1 1 1 Negative Genetic
CEM1 YER061C Mitochondrial beta-keto-acyl synthase genetic 1 1 1 Negative Genetic
ERR1 YOR393W Putative phosphopyruvate hydratase genetic 1 1 1 Negative Genetic
AVL9 YLR114C Conserved protein involved in exocytic transport from the Golgi genetic 1 1 1 Negative Genetic
ERD1 YDR414C Predicted membrane protein required for lumenal ER protein retention genetic 1 1 1 Negative Genetic
CDC1 YDR182W Putative mannose-ethanolamine phosphate phosphodiesterase genetic 1 1 1 Negative Genetic
HEM3 YDL205C Porphobilinogen deaminase genetic 1 1 1 Negative Genetic
HXT9 YJL219W Putative hexose transporter that is nearly identical to Hxt11p genetic 1 1 1 Negative Genetic
CBT1 YKL208W Protein involved in 5' RNA end processing genetic 1 1 1 Positive Genetic
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 1 1 1 Positive Genetic
CAX4 YGR036C Dolichyl pyrophosphate (Dol-P-P) phosphatase genetic 1 1 1 Positive Genetic