Standard name Systematic name Name description Description
VMA21 YGR105W Integral membrane protein required for V-ATPase function Integral membrane protein required for V-ATPase function; not an actual component of the vacuolar H+-ATPase (V-ATPase) complex; diverged ortholog of human XMEA (X-linked Myopathy with Excessive Autophagy); functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)
Visualize the interactome of VMA21
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.061 0.057 0.083
Endosome 0.051 NaN NaN
Nucleus 0.112 0.066 0.111
Vac/Vac Memb 0.867 0.908 0.799
Mito NaN NaN 0.090

GFP localization & abundance

GFP localization GFP abundance
vacuole 1480

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
VMA21 0 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
HAL5 YJL165C Snf1p-related nutrient-responsive protein kinase genetic 5 2 4 Positive Genetic, Positive Genetic, Synthetic Growth Defect, Positive Genetic, Positive Genetic
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 5 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
VPH1 YOR270C Subunit a of the vacuolar-ATPase V0 domain physical 4 3 4 Affinity Capture-MS, Affinity Capture-Western, PCA, Affinity Capture-Western
VMA6 YLR447C Subunit d of the V0 integral membrane domain of V-ATPase physical 4 3 4 Affinity Capture-MS, Affinity Capture-Western, PCA, Affinity Capture-MS
TLG2 YOL018C Syntaxin-like t-SNARE genetic 4 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
RIM20 YOR275C Protein involved in proteolytic activation of Rim101p genetic 4 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
VPS29 YHR012W Subunit of the membrane-associated retromer complex genetic 4 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
AGE2 YIL044C ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector genetic 4 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
DFG16 YOR030W Probable multiple transmembrane protein genetic 4 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
PMP3 YDR276C Small plasma membrane protein genetic 4 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
RIM11 YMR139W Protein kinase genetic 4 1 3 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 4 3 2 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement
PTK1 YKL198C Putative serine/threonine protein kinase genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CNB1 YKL190W Calcineurin B genetic 3 3 3 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
PKR1 YMR123W V-ATPase assembly factor genetic 3 3 3 Dosage Rescue, Synthetic Growth Defect, Positive Genetic
ARL1 YBR164C Soluble GTPase with a role in regulation of membrane traffic genetic 3 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
GET1 YGL020C Subunit of the GET complex genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
VMA11 YPL234C Vacuolar ATPase V0 domain subunit c' physical 3 2 3 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS
VMA3 YEL027W Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase physical 3 2 3 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS
ERG3 YLR056W C-5 sterol desaturase genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 3 2 2 Negative Genetic, Negative Genetic, Synthetic Growth Defect
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 3 2 2 Synthetic Lethality, Positive Genetic, Positive Genetic
TRS85 YDR108W Component of transport protein particle (TRAPP) complex III genetic 3 2 2 Synthetic Growth Defect, Negative Genetic, Negative Genetic
PEP8 YJL053W Vacuolar protein component of the retromer genetic 3 2 2 Synthetic Growth Defect, Negative Genetic, Negative Genetic
VOA1 YGR106C ER protein that functions in assembly of the V0 sector of V-ATPase genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement
VPS35 YJL154C Endosomal subunit of membrane-associated retromer complex genetic 3 2 2 Synthetic Growth Defect, Negative Genetic, Negative Genetic
MTC4 YBR255W Protein of unknown function genetic 3 2 2 Synthetic Growth Defect, Negative Genetic, Negative Genetic
NAP1 YKR048C Histone chaperone and assembly chaperone for Rps6a/b genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
LHP1 YDL051W RNA binding protein required for maturation of tRNA and U6 snRNA genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
DPB4 YDR121W Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PEX29 YDR479C ER-resident protein involved in peroxisomal biogenesis genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
SIP4 YJL089W C6 zinc cluster transcriptional activator genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VPS51 YKR020W Component of the GARP (Golgi-associated retrograde protein) complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VPS38 YLR360W Part of a Vps34p phosphatidylinositol 3-kinase complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
YSP3 YOR003W Putative precursor of the subtilisin-like protease III genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
DCR2 YLR361C Protein phosphatase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SRY1 YKL218C 3-hydroxyaspartate dehydratase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
DGK1 YOR311C Diacylglycerol kinase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MDM20 YOL076W Non-catalytic subunit of the NatB N-terminal acetyltransferase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
MPE1 YKL059C Subunit of CPF cleavage and polyadenylation factor and E3 Ub-ligase genetic 2 2 2 Positive Genetic, Negative Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
HTZ1 YOL012C Histone variant H2AZ genetic 2 2 2 Positive Genetic, Synthetic Growth Defect
APM1 YPL259C Mu1-like medium subunit of the AP-1 complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
OPI1 YHL020C Transcriptional regulator of a variety of genes genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SLA1 YBL007C Cytoskeletal protein binding protein genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
FET4 YMR319C Low-affinity Fe(II) transporter of the plasma membrane genetic 2 2 2 Synthetic Growth Defect, Dosage Rescue
AAT2 YLR027C Cytosolic aspartate aminotransferase involved in nitrogen metabolism genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
CAT5 YOR125C Protein required for ubiquinone (Coenzyme Q) biosynthesis genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
PCL6 YER059W Pho85p cyclin of the Pho80p subfamily genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
PHO86 YJL117W Endoplasmic reticulum (ER) resident protein genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
ATS1 YAL020C Protein required for modification of wobble nucleosides in tRNA genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SRN2 YLR119W Component of the ESCRT-I complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CCZ1 YBR131W Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
HMT1 YBR034C Nuclear SAM-dependent mono- and asymmetric methyltransferase genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
DFG5 YMR238W Putative mannosidase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
VAC8 YEL013W Vacuole-specific Myo2p receptor genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CPR7 YJR032W Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
BSD2 YBR290W Heavy metal ion homeostasis protein genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
VOA1 YGR106C ER protein that functions in assembly of the V0 sector of V-ATPase physical 2 2 2 PCA, Affinity Capture-MS
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
VPS52 YDR484W Component of the GARP (Golgi-associated retrograde protein) complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
VPS9 YML097C Guanine nucleotide exchange factor (GEF) and ubiquitin receptor genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
VPS21 YOR089C Endosomal Rab family GTPase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
VPS60 YDR486C Protein involved in late endosome to vacuole transport genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 2 2 2 Negative Genetic, Positive Genetic
FTR1 YER145C High affinity iron permease genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RPL17B YJL177W Ribosomal 60S subunit protein L17B genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
MYG1 YER156C Protein involved in mitochondrial function genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
ERD1 YDR414C Predicted membrane protein required for lumenal ER protein retention genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
FMC1 YIL098C Mitochondrial matrix protein genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RSM28 YDR494W Mitochondrial ribosomal protein of the small subunit genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
ECM38 YLR299W Gamma-glutamyltranspeptidase genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
IRC21 YMR073C Protein of unknown function genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
UBP13 YBL067C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
VAM10 YOR068C Protein involved in vacuole morphogenesis genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RIM9 YMR063W Plasma membrane protein of unknown function genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
MAK21 YDR060W Constituent of 66S pre-ribosomal particles genetic 2 1 2 Negative Genetic, Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 1 2 Negative Genetic, Negative Genetic
ARC35 YNR035C Subunit of the ARP2/3 complex genetic 2 1 2 Negative Genetic, Negative Genetic
ENP1 YBR247C Protein associated with U3 and U14 snoRNAs genetic 2 1 2 Negative Genetic, Negative Genetic
IWR1 YDL115C RNA polymerase II transport factor, conserved from yeast to humans genetic 2 1 2 Negative Genetic, Negative Genetic
RAV1 YJR033C Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase genetic 2 1 2 Positive Genetic, Positive Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 2 1 2 Negative Genetic, Negative Genetic
CHZ1 YER030W Histone chaperone for Htz1p/H2A-H2B dimer genetic 2 1 2 Positive Genetic, Positive Genetic
ERG11 YHR007C Lanosterol 14-alpha-demethylase genetic 2 1 2 Negative Genetic, Negative Genetic
ERV46 YAL042W Protein localized to COPII-coated vesicles genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
HAC1 YFL031W Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
VMA16 YHR026W Subunit c'' of the vacuolar ATPase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
VMA3 YEL027W Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase genetic 2 1 2 Positive Genetic, Positive Genetic
VMA9 YCL005W-A Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex genetic 2 1 2 Positive Genetic, Positive Genetic
VMA8 YEL051W Subunit D of the V1 peripheral membrane domain of V-ATPase genetic 2 1 2 Positive Genetic, Positive Genetic
WBP1 YEL002C Beta subunit of the oligosaccharyl transferase glycoprotein complex genetic 2 1 2 Negative Genetic, Negative Genetic
ZRG8 YER033C Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
WHI3 YNL197C RNA binding protein that modulates mRNA stability genetic 2 1 2 Negative Genetic, Negative Genetic
SEC11 YIR022W 18kDa catalytic subunit of the Signal Peptidase Complex (SPC) genetic 2 1 2 Negative Genetic, Negative Genetic
TSC13 YDL015C Enoyl reductase genetic 2 1 2 Negative Genetic, Negative Genetic
QDR2 YIL121W Plasma membrane transporter of the major facilitator superfamily genetic 2 1 2 Positive Genetic, Positive Genetic
SWF1 YDR126W Palmitoyltransferase that acts on transmembrane proteins genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
RML2 YEL050C Mitochondrial ribosomal protein of the large subunit (L2) genetic 2 1 2 Positive Genetic, Positive Genetic
MND1 YGL183C Protein required for recombination and meiotic nuclear division genetic 2 1 2 Negative Genetic, Negative Genetic
ORM1 YGR038W Protein that mediates sphingolipid homeostasis genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
AIP1 YMR092C Actin cortical patch component genetic 2 1 1 Negative Genetic, Negative Genetic
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 2 1 1 Positive Genetic, Positive Genetic
RGA1 YOR127W GTPase-activating protein for polarity-regulator Cdc42p (RhoGAP) genetic 2 1 1 Positive Genetic, Positive Genetic
RPA14 YDR156W RNA polymerase I subunit A14 genetic 2 1 1 Negative Genetic, Negative Genetic
ERF2 YLR246W Subunit of a palmitoyltransferase genetic 2 1 1 Negative Genetic, Negative Genetic
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II genetic 2 1 1 Negative Genetic, Negative Genetic
PCK1 YKR097W Phosphoenolpyruvate carboxykinase genetic 2 1 1 Positive Genetic, Positive Genetic
HXT2 YMR011W High-affinity glucose transporter of the major facilitator superfamily genetic 2 1 1 Negative Genetic, Negative Genetic
FRT1 YOR324C Tail-anchored ER membrane protein of unknown function genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SHC1 YER096W Sporulation-specific activator of Chs3p (chitin synthase III) genetic 2 1 1 Negative Genetic, Negative Genetic
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC73 YLR418C Component of the Paf1p complex physical 1 1 1 Affinity Capture-MS
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription genetic 1 1 1 Synthetic Growth Defect
CEF1 YMR213W Essential splicing factor genetic 1 1 1 Negative Genetic
DSN1 YIR010W Essential component of the outer kinetochore MIND complex genetic 1 1 1 Negative Genetic
LEO1 YOR123C Component of the Paf1 complex genetic 1 1 1 Synthetic Growth Defect
RPB3 YIL021W RNA polymerase II third largest subunit B44 genetic 1 1 1 Negative Genetic
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) genetic 1 1 1 Synthetic Growth Defect
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 1 1 1 Synthetic Growth Defect
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) genetic 1 1 1 Synthetic Growth Defect
IKI3 YLR384C Subunit of Elongator complex genetic 1 1 1 Synthetic Growth Defect
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin genetic 1 1 1 Negative Genetic
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Synthetic Growth Defect
BRX1 YOL077C Nucleolar protein genetic 1 1 1 Negative Genetic
DRS1 YLL008W Nucleolar DEAD-box protein required for ribosome assembly and function genetic 1 1 1 Negative Genetic
NOG1 YPL093W Putative GTPase genetic 1 1 1 Negative Genetic
RPF2 YKR081C Essential protein involved in rRNA maturation and ribosomal assembly genetic 1 1 1 Negative Genetic
RPL10 YLR075W Ribosomal 60S subunit protein L10 genetic 1 1 1 Negative Genetic
RLP7 YNL002C Nucleolar protein similar to large ribosomal subunit L7 proteins genetic 1 1 1 Negative Genetic
NOP9 YJL010C Essential subunit of U3-containing 90S preribosome genetic 1 1 1 Positive Genetic
PEX7 YDR142C Peroxisomal signal receptor for peroxisomal matrix proteins genetic 1 1 1 Negative Genetic
AXL2 YIL140W Integral plasma membrane protein genetic 1 1 1 Positive Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Synthetic Lethality
SNU114 YKL173W GTPase component of U5 snRNP involved in mRNA splicing via spliceosome genetic 1 1 1 Negative Genetic
NSE5 YML023C Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Synthetic Growth Defect
RRP14 YKL082C Essential protein, constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
POL5 YEL055C Protein involved in 60S assembly and pre-40S AFs recycling genetic 1 1 1 Negative Genetic
KES1 YPL145C Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger genetic 1 1 1 Synthetic Growth Defect
MRT4 YKL009W Protein involved in mRNA turnover and ribosome assembly genetic 1 1 1 Negative Genetic
GUS1 YGL245W Glutamyl-tRNA synthetase (GluRS) genetic 1 1 1 Negative Genetic
BMH1 YER177W 14-3-3 protein, major isoform genetic 1 1 1 Synthetic Growth Defect
GAR1 YHR089C Protein component of the H/ACA snoRNP pseudouridylase complex genetic 1 1 1 Negative Genetic
DBP7 YKR024C Putative ATP-dependent RNA helicase of the DEAD-box family genetic 1 1 1 Synthetic Growth Defect
HCA4 YJL033W DEAD box RNA helicase genetic 1 1 1 Positive Genetic
SAP155 YFR040W Protein required for function of the Sit4p protein phosphatase genetic 1 1 1 Synthetic Growth Defect
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Synthetic Growth Defect
RPS4B YHR203C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 1 1 1 Negative Genetic
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
DIS3 YOL021C Exosome core complex catalytic subunit genetic 1 1 1 Negative Genetic
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 1 1 1 Synthetic Growth Defect
RPA190 YOR341W RNA polymerase I largest subunit A190 genetic 1 1 1 Negative Genetic
RPA43 YOR340C RNA polymerase I subunit A43 genetic 1 1 1 Negative Genetic
RPL3 YOR063W Ribosomal 60S subunit protein L3 genetic 1 1 1 Negative Genetic
STO1 YMR125W Large subunit of the nuclear mRNA cap-binding protein complex genetic 1 1 1 Synthetic Growth Defect
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
SRB4 YER022W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
DST1 YGL043W General transcription elongation factor TFIIS genetic 1 1 1 Synthetic Growth Defect
CEX1 YOR112W Component of nuclear aminoacylation-dependent tRNA export pathway genetic 1 1 1 Synthetic Growth Defect
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Positive Genetic
UBP6 YFR010W Ubiquitin-specific protease genetic 1 1 1 Synthetic Growth Defect
HCR1 YLR192C eIF3j component of translation initiation factor 3 (eIF3) genetic 1 1 1 Synthetic Growth Defect
PRT1 YOR361C eIF3b subunit of the eukaryotic translation initiation factor 3 (eIF3) genetic 1 1 1 Positive Genetic
GCD1 YOR260W Gamma subunit of the translation initiation factor eIF2B genetic 1 1 1 Negative Genetic
RBG2 YGR173W Protein with a role in translation genetic 1 1 1 Synthetic Growth Defect
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Synthetic Growth Defect
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex genetic 1 1 1 Negative Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily genetic 1 1 1 Synthetic Growth Defect
BMS1 YPL217C GTPase required for ribosomal subunit synthesis and rRNA processing genetic 1 1 1 Negative Genetic
REB1 YBR049C RNA polymerase I enhancer binding protein genetic 1 1 1 Negative Genetic
SUP35 YDR172W Translation termination factor eRF3 genetic 1 1 1 Negative Genetic
TSR2 YLR435W Protein with a potential role in pre-rRNA processing genetic 1 1 1 Synthetic Growth Defect
EFT2 YDR385W Elongation factor 2 (EF-2), also encoded by EFT1 genetic 1 1 1 Synthetic Growth Defect
HGH1 YGR187C Chaperone protein for translation factor eEF2 genetic 1 1 1 Synthetic Growth Defect
APL5 YPL195W Delta adaptin-like subunit of the clathrin associated protein complex genetic 1 1 1 Synthetic Growth Defect
APL6 YGR261C Beta3-like subunit of the yeast AP-3 complex genetic 1 1 1 Synthetic Growth Defect
ARO1 YDR127W Pentafunctional arom protein genetic 1 1 1 Synthetic Growth Defect
ARP2 YDL029W Essential component of the Arp2/3 complex genetic 1 1 1 Negative Genetic
ASF1 YJL115W Nucleosome assembly factor genetic 1 1 1 Synthetic Growth Defect
BAT1 YHR208W Mitochondrial branched-chain amino acid (BCAA) aminotransferase genetic 1 1 1 Negative Genetic
BDF1 YLR399C BET family transcriptional regulator genetic 1 1 1 Synthetic Growth Defect
BEM1 YBR200W Protein containing SH3-domains genetic 1 1 1 Synthetic Growth Defect
BMH2 YDR099W 14-3-3 protein, minor isoform genetic 1 1 1 Negative Genetic
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p genetic 1 1 1 Synthetic Growth Defect
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 1 1 1 Synthetic Growth Defect
BUD14 YAR014C Protein involved in bud-site selection genetic 1 1 1 Synthetic Growth Defect
CAF40 YNL288W Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Negative Genetic
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Positive Genetic
ATP11 YNL315C Molecular chaperone genetic 1 1 1 Negative Genetic
CDC36 YDL165W Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 1 1 1 Negative Genetic
DBP10 YDL031W Putative ATP-dependent RNA helicase of the DEAD-box protein family genetic 1 1 1 Negative Genetic
AVO1 YOL078W Component of the membrane-bound TORC2 complex genetic 1 1 1 Negative Genetic
CIP1 YPL014W Cyclin-dependent kinase inhibitor genetic 1 1 1 Negative Genetic
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 1 1 1 Synthetic Growth Defect
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 1 1 1 Synthetic Growth Defect
ELP2 YGR200C Subunit of Elongator complex genetic 1 1 1 Synthetic Growth Defect
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex genetic 1 1 1 Synthetic Growth Defect
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase genetic 1 1 1 Synthetic Growth Defect
FTH1 YBR207W Putative high affinity iron transporter genetic 1 1 1 Negative Genetic
GCN1 YGL195W Positive regulator of the Gcn2p kinase activity genetic 1 1 1 Synthetic Growth Defect
GGA2 YHR108W Protein that regulates Arf1p, Arf2p to facilitate Golgi trafficking genetic 1 1 1 Negative Genetic
ERV25 YML012W Member of the p24 family involved in ER to Golgi transport physical 1 1 1 PCA
GLY1 YEL046C Threonine aldolase genetic 1 1 1 Synthetic Growth Defect
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
AEP1 YMR064W Protein required for expression of the mitochondrial OLI1 gene genetic 1 1 1 Negative Genetic
COG8 YML071C Component of the conserved oligomeric Golgi complex genetic 1 1 1 Synthetic Growth Defect
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers genetic 1 1 1 Synthetic Growth Defect
ESC8 YOL017W Protein involved in telomeric and mating-type locus silencing genetic 1 1 1 Negative Genetic
ISW2 YOR304W ATP-dependent DNA translocase involved in chromatin remodeling genetic 1 1 1 Negative Genetic
LCB1 YMR296C Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
MAS1 YLR163C Beta subunit of the mitochondrial processing protease (MPP) genetic 1 1 1 Negative Genetic
MDM10 YAL010C Subunit of both the ERMES and the SAM complex genetic 1 1 1 Synthetic Growth Defect
GAL11 YOL051W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
ADA2 YDR448W Transcription coactivator genetic 1 1 1 Synthetic Growth Defect
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 1 1 1 Negative Genetic
MED6 YHR058C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
MLH1 YMR167W Protein required for mismatch repair in mitosis and meiosis genetic 1 1 1 Negative Genetic
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
HRR25 YPL204W Conserved casein kinase, monopolin subunit genetic 1 1 1 Negative Genetic
IMG2 YCR071C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Synthetic Growth Defect
MRPL10 YNL284C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MRPL35 YDR322W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Synthetic Growth Defect
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 1 1 1 Negative Genetic
MGM101 YJR144W Protein with a role in mitochondrial DNA recombinational repair genetic 1 1 1 Synthetic Growth Defect
CMD1 YBR109C Calmodulin genetic 1 1 1 Positive Genetic
NCL1 YBL024W S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase genetic 1 1 1 Positive Genetic
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
ATG18 YFR021W Phosphoinositide binding protein genetic 1 1 1 Negative Genetic
LPD1 YFL018C Dihydrolipoamide dehydrogenase genetic 1 1 1 Synthetic Growth Defect
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex genetic 1 1 1 Synthetic Growth Defect
PDB1 YBR221C E1 beta subunit of the pyruvate dehydrogenase (PDH) complex genetic 1 1 1 Synthetic Growth Defect
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase genetic 1 1 1 Synthetic Growth Defect
IDH2 YOR136W Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase genetic 1 1 1 Synthetic Growth Defect
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation genetic 1 1 1 Synthetic Growth Defect
GLE2 YER107C RNA export factor associated with the nuclear pore complex (NPC) genetic 1 1 1 Positive Genetic
PRP4 YPR178W Splicing factor genetic 1 1 1 Positive Genetic
PUB1 YNL016W Poly (A)+ RNA-binding protein genetic 1 1 1 Positive Genetic
MVD1 YNR043W Mevalonate pyrophosphate decarboxylase genetic 1 1 1 Negative Genetic
ESF2 YNR054C Essential nucleolar protein involved in pre-18S rRNA processing genetic 1 1 1 Negative Genetic
MET18 YIL128W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Synthetic Growth Defect
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Synthetic Growth Defect
RAM1 YDL090C Beta subunit of the CAAX farnesyltransferase (FTase) genetic 1 1 1 Negative Genetic
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) physical 1 1 1 Two-hybrid
PGD1 YGL025C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
RPB8 YOR224C RNA polymerase subunit ABC14.5 genetic 1 1 1 Negative Genetic
RPL2A YFR031C-A Ribosomal 60S subunit protein L2A genetic 1 1 1 Synthetic Growth Defect
MAF1 YDR005C Highly conserved negative regulator of RNA polymerase III genetic 1 1 1 Synthetic Growth Defect
RTS1 YOR014W B-type regulatory subunit of protein phosphatase 2A (PP2A) genetic 1 1 1 Synthetic Growth Defect
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism genetic 1 1 1 Synthetic Growth Defect
PIL1 YGR086C Eisosome core component genetic 1 1 1 Synthetic Growth Defect
RSA4 YCR072C Ribosomal large subunit (60S) assembly factor genetic 1 1 1 Negative Genetic
ANP1 YEL036C Subunit of the alpha-1,6 mannosyltransferase complex genetic 1 1 1 Synthetic Growth Defect
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Synthetic Growth Defect
SEC62 YPL094C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
SEC63 YOR254C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 1 1 1 Synthetic Growth Defect
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 1 1 1 Synthetic Growth Defect
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 1 1 1 Synthetic Growth Defect
CDC25 YLR310C Membrane bound guanine nucleotide exchange factor genetic 1 1 1 Negative Genetic
INP52 YNL106C Polyphosphatidylinositol phosphatase genetic 1 1 1 Negative Genetic
LSB3 YFR024C-A Protein containing a C-terminal SH3 domain genetic 1 1 1 Synthetic Growth Defect
SEC17 YBL050W Alpha-SNAP cochaperone genetic 1 1 1 Negative Genetic
CCT8 YJL008C Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
SNF1 YDR477W AMP-activated S/T protein kinase genetic 1 1 1 Synthetic Growth Defect
SNF2 YOR290C Catalytic subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
SPE3 YPR069C Spermidine synthase genetic 1 1 1 Synthetic Growth Defect
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex genetic 1 1 1 Synthetic Growth Defect
SRB8 YCR081W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Negative Genetic
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 1 1 1 Positive Genetic
TAF3 YPL011C TFIID subunit (47 kDa) genetic 1 1 1 Negative Genetic
MGA2 YIR033W ER membrane protein involved in regulation of OLE1 transcription genetic 1 1 1 Synthetic Growth Defect
NEW1 YPL226W Translation termination and ribosome biogenesis factor genetic 1 1 1 Negative Genetic
TKL1 YPR074C Transketolase genetic 1 1 1 Negative Genetic
SCJ1 YMR214W One of several homologs of bacterial chaperone DnaJ genetic 1 1 1 Synthetic Growth Defect
TPD3 YAL016W Regulatory subunit A of the heterotrimeric PP2A complex genetic 1 1 1 Synthetic Growth Defect
MKS1 YNL076W Pleiotropic negative transcriptional regulator genetic 1 1 1 Synthetic Growth Defect
TPS1 YBR126C Synthase subunit of trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Synthetic Growth Defect
TRP2 YER090W Anthranilate synthase genetic 1 1 1 Synthetic Growth Defect
TRS130 YMR218C Component of transport protein particle (TRAPP) complex II genetic 1 1 1 Negative Genetic
UBA3 YPR066W Protein that activates Rub1p (NEDD8) before neddylation genetic 1 1 1 Synthetic Growth Defect
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 1 1 1 Synthetic Growth Defect
UBP15 YMR304W Ubiquitin-specific protease involved in protein deubiquitination genetic 1 1 1 Synthetic Growth Defect
VMA13 YPR036W Subunit H of the V1 peripheral membrane domain of V-ATPase physical 1 1 1 PCA
VMA13 YPR036W Subunit H of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Positive Genetic
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p genetic 1 1 1 Synthetic Growth Defect
TLG1 YDR468C Essential t-SNARE that mediates fusion of vesicles with the late Golgi genetic 1 1 1 Negative Genetic
SWP1 YMR149W Delta subunit of the oligosaccharyl transferase glycoprotein complex genetic 1 1 1 Negative Genetic
DRS2 YAL026C Trans-golgi network aminophospholipid translocase (flippase) genetic 1 1 1 Synthetic Growth Defect
FLC2 YAL053W Putative calcium channel involved in calcium release under hypotonic genetic 1 1 1 Synthetic Growth Defect
BRE2 YLR015W Subunit of COMPASS (Set1C) complex genetic 1 1 1 Synthetic Growth Defect
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Synthetic Growth Defect
SDC1 YDR469W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Synthetic Growth Defect
PIN4 YBL051C Protein involved in G2/M phase progression and response to DNA damage genetic 1 1 1 Synthetic Growth Defect
GET3 YDL100C Guanine nucleotide exchange factor for Gpa1p genetic 1 1 1 Synthetic Growth Defect
BNA3 YJL060W Kynurenine aminotransferase genetic 1 1 1 Negative Genetic
ATP2 YJR121W Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase physical 1 1 1 Affinity Capture-MS
CRZ1 YNL027W Transcription factor, activates transcription of stress response genes genetic 1 1 1 Synthetic Growth Defect
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 1 1 1 Synthetic Growth Defect
ACO1 YLR304C Aconitase genetic 1 1 1 Synthetic Growth Defect
FAR8 YMR029C Protein involved in recovery from arrest in response to pheromone genetic 1 1 1 Negative Genetic
FAR7 YFR008W Protein involved in recovery from pheromone-induced cell cycle arrest genetic 1 1 1 Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Synthetic Growth Defect
PHO85 YPL031C Cyclin-dependent kinase genetic 1 1 1 Synthetic Growth Defect
ADO1 YJR105W Adenosine kinase genetic 1 1 1 Synthetic Growth Defect
PPQ1 YPL179W Protein phosphatase that regulates the mating response genetic 1 1 1 Negative Genetic
RIM15 YFL033C Protein kinase involved in cell proliferation in response to nutrients genetic 1 1 1 Negative Genetic
DCS1 YLR270W Non-essential hydrolase involved in mRNA decapping genetic 1 1 1 Positive Genetic
ARF1 YDL192W ADP-ribosylation factor genetic 1 1 1 Synthetic Growth Defect
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway genetic 1 1 1 Synthetic Growth Defect
GSF2 YML048W Endoplasmic reticulum (ER) localized integral membrane protein genetic 1 1 1 Synthetic Growth Defect
FET3 YMR058W Ferro-O2-oxidoreductase genetic 1 1 1 Synthetic Growth Defect
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Synthetic Growth Defect
FYV10 YIL097W Subunit of GID complex genetic 1 1 1 Synthetic Growth Defect
APM3 YBR288C Mu3-like subunit of the clathrin associated protein complex (AP-3) genetic 1 1 1 Synthetic Growth Defect
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Synthetic Growth Defect
EGD1 YPL037C Subunit beta1 of the nascent polypeptide-associated complex (NAC) genetic 1 1 1 Positive Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Synthetic Growth Defect
PHO81 YGR233C Cyclin-dependent kinase (CDK) inhibitor genetic 1 1 1 Synthetic Growth Defect
PDI1 YCL043C Protein disulfide isomerase genetic 1 1 1 Negative Genetic
GPD2 YOL059W NAD-dependent glycerol 3-phosphate dehydrogenase genetic 1 1 1 Negative Genetic
MDM30 YLR368W F-box component of an SCF ubiquitin protein ligase complex genetic 1 1 1 Positive Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Positive Genetic
PCT1 YGR202C Cholinephosphate cytidylyltransferase genetic 1 1 1 Synthetic Growth Defect
KRE6 YPR159W Glucosyl hydrolase required for beta-1,6-glucan biosynthesis genetic 1 1 1 Synthetic Growth Defect
SOD2 YHR008C Mitochondrial manganese superoxide dismutase genetic 1 1 1 Synthetic Growth Defect
FUM1 YPL262W Fumarase genetic 1 1 1 Synthetic Growth Defect
MRS6 YOR370C Rab escort protein genetic 1 1 1 Negative Genetic
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Negative Genetic
DUG2 YBR281C Component of glutamine amidotransferase (GATase II) genetic 1 1 1 Negative Genetic
PDS1 YDR113C Securin genetic 1 1 1 Negative Genetic
SKP2 YNL311C F-box protein of unknown function genetic 1 1 1 Positive Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Synthetic Growth Defect
GPA2 YER020W Nucleotide binding alpha subunit of the heterotrimeric G protein genetic 1 1 1 Synthetic Growth Defect
SMC6 YLR383W Subunit of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Positive Genetic
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription genetic 1 1 1 Negative Genetic
UFD2 YDL190C Ubiquitin (Ub) chain assembly factor (E4) genetic 1 1 1 Synthetic Growth Defect
OCA1 YNL099C Putative protein tyrosine phosphatase genetic 1 1 1 Negative Genetic
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 1 1 1 Negative Genetic
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Growth Defect
MAK11 YKL021C Protein involved in an early step of 60S ribosomal subunit biogenesis genetic 1 1 1 Negative Genetic
GLE1 YDL207W Cytoplasmic nucleoporin required for polyadenylated mRNA export genetic 1 1 1 Negative Genetic
NTF2 YER009W Nuclear envelope protein genetic 1 1 1 Positive Genetic
DNL4 YOR005C DNA ligase required for nonhomologous end-joining (NHEJ) genetic 1 1 1 Negative Genetic
ADD66 YKL206C Protein involved in 20S proteasome assembly genetic 1 1 1 Positive Genetic
LAS1 YKR063C Endonuclease involved in pre-rRNA processing at both ends of ITS2 genetic 1 1 1 Negative Genetic
GIS4 YML006C CAAX box containing protein of unknown function genetic 1 1 1 Synthetic Growth Defect
DIA2 YOR080W Origin-binding F-box protein genetic 1 1 1 Synthetic Growth Defect
CTF4 YPR135W Chromatin-associated protein genetic 1 1 1 Synthetic Growth Defect
BEM4 YPL161C Protein involved in establishment of cell polarity and bud emergence genetic 1 1 1 Synthetic Growth Defect
BCK2 YER167W Serine/threonine-rich protein involved in PKC1 signaling pathway genetic 1 1 1 Synthetic Growth Defect
SHS1 YDL225W Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) genetic 1 1 1 Negative Genetic
STB4 YMR019W Putative transcription factor genetic 1 1 1 Negative Genetic
RTT103 YDR289C Protein involved in transcription termination by RNA polymerase II genetic 1 1 1 Synthetic Growth Defect
NUP2 YLR335W Nucleoporin involved in nucleocytoplasmic transport genetic 1 1 1 Positive Genetic
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 1 1 1 Synthetic Growth Defect
NDE1 YMR145C Mitochondrial external NADH dehydrogenase genetic 1 1 1 Positive Genetic
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Negative Genetic
TEF4 YKL081W Gamma subunit of translational elongation factor eEF1B genetic 1 1 1 Synthetic Growth Defect
UBC7 YMR022W Ubiquitin conjugating enzyme genetic 1 1 1 Synthetic Growth Defect
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Synthetic Growth Defect
DUF1 YOL087C Ubiquitin-binding protein of unknown function genetic 1 1 1 Synthetic Growth Defect
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 1 1 1 Synthetic Growth Defect
CYS3 YAL012W Cystathionine gamma-lyase genetic 1 1 1 Synthetic Growth Defect
APE3 YBR286W Vacuolar aminopeptidase Y genetic 1 1 1 Synthetic Growth Defect
HFL1 YKR051W Vacuole membrane protein that interacts with Atg8p genetic 1 1 1 Synthetic Growth Defect
EXO70 YJL085W Subunit of the exocyst complex genetic 1 1 1 Negative Genetic
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 1 1 1 Negative Genetic
ERG11 YHR007C Lanosterol 14-alpha-demethylase physical 1 1 1 PCA
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 1 1 1 Synthetic Growth Defect
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex genetic 1 1 1 Synthetic Growth Defect
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Synthetic Growth Defect
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 1 1 1 Synthetic Growth Defect
KKQ8 YKL168C Putative serine/threonine protein kinase with unknown cellular role genetic 1 1 1 Negative Genetic
SRV2 YNL138W CAP (cyclase-associated protein) genetic 1 1 1 Negative Genetic
ATP7 YKL016C Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase genetic 1 1 1 Negative Genetic
DAD2 YKR083C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
SNO1 YMR095C Protein of unconfirmed function genetic 1 1 1 Negative Genetic
SKA1 YKL023W SKI complex-associated protein genetic 1 1 1 Synthetic Growth Defect
CSM2 YIL132C Subunit of the Shu complex (aka PCSS complex) genetic 1 1 1 Negative Genetic
UBA4 YHR111W E1-like protein that activates Urm1p before urmylation genetic 1 1 1 Synthetic Growth Defect
NAS2 YIL007C Evolutionarily conserved 19S regulatory particle assembly-chaperone genetic 1 1 1 Positive Genetic
SNF8 YPL002C Component of the ESCRT-II complex genetic 1 1 1 Synthetic Growth Defect
DID4 YKL002W Class E Vps protein of the ESCRT-III complex genetic 1 1 1 Synthetic Growth Defect
CPR2 YHR057C Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Synthetic Growth Defect
MCM10 YIL150C Essential chromatin-associated protein genetic 1 1 1 Negative Genetic
FAR3 YMR052W Protein of unknown function genetic 1 1 1 Negative Genetic
FUI1 YBL042C High affinity uridine permease, localizes to the plasma membrane genetic 1 1 1 Synthetic Growth Defect
ARG81 YML099C Zinc finger transcription factor involved in arginine-responsive genes genetic 1 1 1 Negative Genetic
ACO2 YJL200C Putative mitochondrial aconitase isozyme genetic 1 1 1 Synthetic Growth Defect
HCS1 YKL017C Hexameric DNA polymerase alpha-associated DNA helicase A genetic 1 1 1 Positive Genetic
INO2 YDR123C Transcription factor genetic 1 1 1 Synthetic Growth Defect
CWC24 YLR323C General splicing factor genetic 1 1 1 Negative Genetic
MPD2 YOL088C Member of the protein disulfide isomerase (PDI) family genetic 1 1 1 Synthetic Growth Defect
MSN5 YDR335W Karyopherin genetic 1 1 1 Synthetic Growth Defect
NDL1 YLR254C Homolog of nuclear distribution factor NudE genetic 1 1 1 Negative Genetic
PCL8 YPL219W Cyclin genetic 1 1 1 Negative Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Positive Genetic
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Synthetic Growth Defect
ATG27 YJL178C Type I membrane protein involved in autophagy and the Cvt pathway genetic 1 1 1 Synthetic Growth Defect
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Negative Genetic
PET191 YJR034W Protein required for assembly of cytochrome c oxidase genetic 1 1 1 Synthetic Growth Defect
JSN1 YJR091C Member of the Puf family of RNA-binding proteins genetic 1 1 1 Negative Genetic
TOP1 YOL006C Topoisomerase I genetic 1 1 1 Synthetic Growth Defect
VAM7 YGL212W Vacuolar SNARE protein genetic 1 1 1 Synthetic Growth Defect
MVP1 YMR004W Protein required for sorting proteins to the vacuole genetic 1 1 1 Negative Genetic
LDB17 YDL146W Protein involved in the regulation of endocytosis genetic 1 1 1 Negative Genetic
KTI12 YKL110C Protein that plays a role in modification of tRNA wobble nucleosides genetic 1 1 1 Synthetic Growth Defect
LAM6 YLR072W Sterol transporter that transfers sterols between membranes genetic 1 1 1 Negative Genetic
URE2 YNL229C Nitrogen catabolite repression transcriptional regulator genetic 1 1 1 Synthetic Growth Defect
ELP6 YMR312W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Synthetic Growth Defect
SNO4 YMR322C Possible chaperone and cysteine protease genetic 1 1 1 Negative Genetic
MDY2 YOL111C Protein involved in inserting tail-anchored proteins into ER membranes genetic 1 1 1 Synthetic Growth Defect
BLI1 YKL061W Subunit of the BLOC-1 complex involved in endosomal maturation genetic 1 1 1 Synthetic Growth Defect
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 1 1 1 Synthetic Growth Defect
PEP12 YOR036W Target membrane receptor (t-SNARE) genetic 1 1 1 Synthetic Growth Defect
COG4 YPR105C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex genetic 1 1 1 Synthetic Growth Defect
SIW14 YNL032W Inositol phosphatase involved in inositol pyrophosphate metabolism genetic 1 1 1 Negative Genetic
COG7 YGL005C Component of the conserved oligomeric Golgi complex genetic 1 1 1 Synthetic Growth Defect
COG6 YNL041C Component of the conserved oligomeric Golgi complex genetic 1 1 1 Synthetic Growth Defect
COG5 YNL051W Component of the conserved oligomeric Golgi complex genetic 1 1 1 Synthetic Growth Defect
ELP3 YPL086C Subunit of Elongator complex genetic 1 1 1 Synthetic Growth Defect
ELP4 YPL101W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Synthetic Growth Defect
GRC3 YLL035W Polynucleotide kinase present on rDNA genetic 1 1 1 Negative Genetic
RFT1 YBL020W Membrane protein required for translocation of Man5GlcNac2-PP-Dol genetic 1 1 1 Negative Genetic
RPS4A YJR145C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
RPL9A YGL147C Ribosomal 60S subunit protein L9A genetic 1 1 1 Synthetic Growth Defect
RPS24A YER074W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 1 1 1 Synthetic Growth Defect
SPT4 YGR063C Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 1 1 1 Synthetic Growth Defect
CET1 YPL228W RNA 5'-triphosphatase involved in mRNA 5' capping genetic 1 1 1 Negative Genetic
SAC3 YDR159W mRNA export factor genetic 1 1 1 Synthetic Growth Defect
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 1 1 1 Synthetic Growth Defect
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes genetic 1 1 1 Negative Genetic
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 1 1 1 Synthetic Growth Defect
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 1 1 1 Synthetic Growth Defect
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Synthetic Growth Defect
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Synthetic Growth Defect
SNF11 YDR073W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
SNF6 YHL025W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
SWI1 YPL016W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Positive Genetic
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 1 1 1 Synthetic Growth Defect
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Synthetic Growth Defect
PHO4 YFR034C Basic helix-loop-helix (bHLH) transcription factor of the myc-family genetic 1 1 1 Synthetic Growth Defect
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Synthetic Growth Defect
TSR1 YDL060W Protein required for processing of 20S pre-rRNA in the cytoplasm genetic 1 1 1 Negative Genetic
RPL20B YOR312C Ribosomal 60S subunit protein L20B genetic 1 1 1 Negative Genetic
RPS11A YDR025W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
RPS11B YBR048W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
RIF1 YBR275C Protein involved in control of DNA replication genetic 1 1 1 Synthetic Growth Defect
ATG8 YBL078C Ub-like protein genetic 1 1 1 Synthetic Growth Defect
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 1 1 1 Negative Genetic
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family genetic 1 1 1 Negative Genetic
ELO3 YLR372W Elongase genetic 1 1 1 Synthetic Growth Defect
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 1 1 1 Negative Genetic
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Synthetic Growth Defect
BNI5 YNL166C Linker protein responsible for recruitment of myosin to the bud neck genetic 1 1 1 Negative Genetic
HOP1 YIL072W Meiosis-specific protein required for chromosome synapsis genetic 1 1 1 Negative Genetic
IOC2 YLR095C Subunit of the Isw1b complex genetic 1 1 1 Synthetic Growth Defect
KAR3 YPR141C Minus-end-directed microtubule motor genetic 1 1 1 Synthetic Growth Defect
MAD1 YGL086W Coiled-coil protein involved in spindle-assembly checkpoint genetic 1 1 1 Negative Genetic
MTR2 YKL186C mRNA transport regulator genetic 1 1 1 Negative Genetic
OST2 YOR103C Epsilon subunit of the oligosaccharyltransferase complex genetic 1 1 1 Negative Genetic
OST3 YOR085W Gamma subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Synthetic Growth Defect
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 1 1 1 Negative Genetic
PHO80 YOL001W Cyclin genetic 1 1 1 Synthetic Growth Defect
RTG2 YGL252C Sensor of mitochondrial dysfunction genetic 1 1 1 Synthetic Growth Defect
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Synthetic Growth Defect
SKN7 YHR206W Nuclear response regulator and transcription factor genetic 1 1 1 Synthetic Growth Defect
RCY1 YJL204C F-box protein involved in recycling endocytosed proteins genetic 1 1 1 Synthetic Growth Defect
RAV2 YDR202C Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) genetic 1 1 1 Synthetic Growth Defect
SRO7 YPR032W Effector of Rab GTPase Sec4p genetic 1 1 1 Synthetic Growth Defect
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 1 1 1 Affinity Capture-MS
SSS1 YDR086C Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) genetic 1 1 1 Negative Genetic
STN1 YDR082W Telomere end-binding and capping protein genetic 1 1 1 Negative Genetic
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 1 1 1 Negative Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Synthetic Growth Defect
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Rescue
NMD2 YHR077C Protein involved in the nonsense-mediated mRNA decay (NMD) pathway genetic 1 1 1 Synthetic Growth Defect
PEP7 YDR323C Adaptor protein involved in vesicle-mediated vacuolar protein sorting genetic 1 1 1 Synthetic Growth Defect
FIG4 YNL325C Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase genetic 1 1 1 Synthetic Growth Defect
STP22 YCL008C Component of the ESCRT-I complex genetic 1 1 1 Synthetic Growth Defect
TRA1 YHR099W Subunit of SAGA and NuA4 histone acetyltransferase complexes genetic 1 1 1 Negative Genetic
DPH2 YKL191W Protein required for synthesis of diphthamide genetic 1 1 1 Synthetic Growth Defect
DPH1 YIL103W Protein required for synthesis of diphthamide genetic 1 1 1 Synthetic Growth Defect
PHO2 YDL106C Homeobox transcription factor genetic 1 1 1 Synthetic Growth Defect
GOS1 YHL031C v-SNARE protein involved in Golgi transport genetic 1 1 1 Synthetic Growth Defect
SNX4 YJL036W Sorting nexin genetic 1 1 1 Synthetic Growth Defect
OST4 YDL232W Subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Synthetic Growth Defect
MBF1 YOR298C-A Transcriptional coactivator genetic 1 1 1 Synthetic Growth Defect
MST28 YAR033W Putative integral membrane protein, involved in vesicle formation genetic 1 1 1 Negative Genetic
SPO20 YMR017W Meiosis-specific subunit of the t-SNARE complex genetic 1 1 1 Negative Genetic
TRS33 YOR115C Core component of TRAPP complexes I, II and IV genetic 1 1 1 Negative Genetic
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Synthetic Growth Defect
SSA3 YBL075C ATPase involved in protein folding and the response to stress genetic 1 1 1 Negative Genetic
GYP1 YOR070C Cis-golgi GTPase-activating protein (GAP) for yeast Rabs genetic 1 1 1 Synthetic Growth Defect
SEC2 YNL272C Guanyl-nucleotide exchange factor for the small G-protein Sec4p genetic 1 1 1 Negative Genetic
PPR1 YLR014C Zinc finger transcription factor genetic 1 1 1 Synthetic Growth Defect
EMC1 YCL045C Member of conserved endoplasmic reticulum membrane complex genetic 1 1 1 Synthetic Growth Defect
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Negative Genetic
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 1 1 1 Negative Genetic
RBL2 YOR265W Protein involved in microtubule morphogenesis genetic 1 1 1 Negative Genetic
RRN9 YMR270C Protein involved in promoting high level transcription of rDNA genetic 1 1 1 Negative Genetic
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 1 1 1 Synthetic Growth Defect
ARG82 YDR173C Inositol polyphosphate multikinase (IPMK) genetic 1 1 1 Synthetic Growth Defect
ERG25 YGR060W C-4 methyl sterol oxidase physical 1 1 1 PCA
INP53 YOR109W Polyphosphatidylinositol phosphatase genetic 1 1 1 Synthetic Growth Defect
DPH6 YLR143W Diphthamide synthetase genetic 1 1 1 Synthetic Growth Defect
MAC1 YMR021C Copper-sensing transcription factor genetic 1 1 1 Synthetic Growth Defect
MON1 YGL124C Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Synthetic Growth Defect
CUS2 YNL286W Putative checkpoint factor in transcription genetic 1 1 1 Negative Genetic
PRP22 YER013W DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
SNZ1 YMR096W Subunit of a two-component pyridoxal-5'-phosphate synthase genetic 1 1 1 Negative Genetic
SPC42 YKL042W Central plaque component of spindle pole body (SPB) genetic 1 1 1 Negative Genetic
OSH3 YHR073W Member of an oxysterol-binding protein family genetic 1 1 1 Negative Genetic
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 1 1 1 Negative Genetic
TEA1 YOR337W Ty1 enhancer activator involved in Ty enhancer-mediated transcription genetic 1 1 1 Negative Genetic
BUD17 YNR027W Putative pyridoxal kinase genetic 1 1 1 Negative Genetic
PEX27 YOR193W Peripheral peroxisomal membrane protein genetic 1 1 1 Negative Genetic
RPL1A YPL220W Ribosomal 60S subunit protein L1A genetic 1 1 1 Negative Genetic
ATP1 YBL099W Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase physical 1 1 1 Affinity Capture-MS
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Synthetic Growth Defect
NIP100 YPL174C Large subunit of the dynactin complex genetic 1 1 1 Negative Genetic
PFY1 YOR122C Profilin genetic 1 1 1 Negative Genetic
CHS5 YLR330W Component of the exomer complex genetic 1 1 1 Synthetic Growth Defect
TCO89 YPL180W Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p) genetic 1 1 1 Synthetic Growth Defect
KEX2 YNL238W Kexin, a subtilisin-like protease (proprotein convertase) genetic 1 1 1 Synthetic Growth Defect
SWC3 YAL011W Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Synthetic Growth Defect
HOC1 YJR075W Alpha-1,6-mannosyltransferase genetic 1 1 1 Synthetic Growth Defect
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
PMT3 YOR321W Protein O-mannosyltransferase genetic 1 1 1 Positive Genetic
DID2 YKR035W-A Class E protein of the vacuolar protein-sorting (Vps) pathway genetic 1 1 1 Synthetic Growth Defect
STV1 YMR054W Subunit a of the vacuolar-ATPase V0 domain genetic 1 1 1 Synthetic Growth Defect
BET4 YJL031C Alpha subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
ARL3 YPL051W ARF-like small GTPase of the RAS superfamily genetic 1 1 1 Synthetic Growth Defect
DOM34 YNL001W Protein that facilitates ribosomal subunit dissociation genetic 1 1 1 Synthetic Growth Defect
VMA11 YPL234C Vacuolar ATPase V0 domain subunit c' genetic 1 1 1 Positive Genetic
SRP101 YDR292C Signal recognition particle (SRP) receptor alpha subunit genetic 1 1 1 Positive Genetic
ERV14 YGL054C COPII-coated vesicle protein genetic 1 1 1 Negative Genetic
RNR4 YGR180C Ribonucleotide-diphosphate reductase (RNR) small subunit genetic 1 1 1 Synthetic Growth Defect
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Synthetic Growth Defect
EAF6 YJR082C Subunit of the NuA4 acetyltransferase complex genetic 1 1 1 Positive Genetic
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 1 1 1 Synthetic Growth Defect
INN1 YNL152W Essential protein that associates with contractile actomyosin ring genetic 1 1 1 Positive Genetic
SYS1 YJL004C Integral membrane protein of the Golgi genetic 1 1 1 Synthetic Growth Defect
TEC1 YBR083W Transcription factor targeting filamentation genes and Ty1 expression genetic 1 1 1 Negative Genetic
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p genetic 1 1 1 Synthetic Growth Defect
RRS1 YOR294W Essential protein that binds ribosomal protein L11 genetic 1 1 1 Negative Genetic
PAR32 YDL173W Low complexity protein genetic 1 1 1 Synthetic Growth Defect
RPL13A YDL082W Ribosomal 60S subunit protein L13A genetic 1 1 1 Synthetic Growth Defect
RPL15A YLR029C Ribosomal 60S subunit protein L15A genetic 1 1 1 Negative Genetic
RPL29 YFR032C-A Ribosomal 60S subunit protein L29 genetic 1 1 1 Synthetic Growth Defect
MIT1 YEL007W Transcriptional regulator of pseudohyphal growth genetic 1 1 1 Synthetic Growth Defect
ADI1 YMR009W Acireductone dioxygenease involved in methionine salvage pathway genetic 1 1 1 Synthetic Growth Defect
REV1 YOR346W Deoxycytidyl transferase genetic 1 1 1 Negative Genetic
KAR5 YMR065W Protein required for nuclear membrane fusion during karyogamy genetic 1 1 1 Negative Genetic
SAC7 YDR389W GTPase activating protein (GAP) for Rho1p genetic 1 1 1 Synthetic Growth Defect
SEC39 YLR440C Component of the Dsl1p tethering complex genetic 1 1 1 Negative Genetic
EMC6 YLL014W Member of conserved ER transmembrane complex genetic 1 1 1 Negative Genetic
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 1 1 1 Synthetic Growth Defect
COY1 YKL179C Golgi membrane protein with similarity to mammalian CASP genetic 1 1 1 Synthetic Growth Defect
EPO1 YMR124W Protein involved in septin-ER tethering genetic 1 1 1 Negative Genetic
GTA1 YEL043W Protein of unknown function genetic 1 1 1 Negative Genetic
PAC1 YOR269W Regulator of dynein, involved in intracellular transport genetic 1 1 1 Negative Genetic
HSP31 YDR533C Methylglyoxalase that converts methylglyoxal to D-lactate genetic 1 1 1 Negative Genetic
GEF1 YJR040W Voltage-gated chloride channel genetic 1 1 1 Synthetic Growth Defect
FRA1 YLL029W Protein involved in negative regulation of iron regulon transcription genetic 1 1 1 Synthetic Growth Defect
CSF1 YLR087C Protein with structural similarity to lipid transport protein Vps13p genetic 1 1 1 Synthetic Growth Defect
ALG1 YBR110W Mannosyltransferase physical 1 1 1 PCA
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Synthetic Growth Defect
SIA1 YOR137C Protein of unassigned function genetic 1 1 1 Negative Genetic
VPH1 YOR270C Subunit a of the vacuolar-ATPase V0 domain genetic 1 1 1 Synthetic Growth Defect
VMA9 YCL005W-A Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex physical 1 1 1 Affinity Capture-Western
VMA8 YEL051W Subunit D of the V1 peripheral membrane domain of V-ATPase physical 1 1 1 PCA
VMA7 YGR020C Subunit F of the V1 peripheral membrane domain of V-ATPase physical 1 1 1 PCA
VMA21 YGR105W Integral membrane protein required for V-ATPase function physical 1 1 1 Affinity Capture-MS
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Synthetic Lethality
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Synthetic Growth Defect
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Synthetic Growth Defect
VPS5 YOR069W Nexin-1 homolog genetic 1 1 1 Synthetic Growth Defect
VTC1 YER072W Regulatory subunit of the vacuolar transporter chaperone (VTC) complex genetic 1 1 1 Synthetic Growth Defect
VTC4 YJL012C Vacuolar membrane polyphosphate polymerase genetic 1 1 1 Synthetic Growth Defect
YCK3 YER123W Palmitoylated vacuolar membrane-localized casein kinase I isoform genetic 1 1 1 Synthetic Growth Defect
YPT7 YML001W Rab family GTPase genetic 1 1 1 Synthetic Growth Defect
VPS17 YOR132W Subunit of the membrane-associated retromer complex genetic 1 1 1 Synthetic Growth Defect
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 1 1 1 Synthetic Growth Defect
VPS33 YLR396C ATP-binding protein that is a subunit of the HOPS and CORVET complexes genetic 1 1 1 Synthetic Growth Defect
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting genetic 1 1 1 Synthetic Growth Defect
VPS25 YJR102C Component of the ESCRT-II complex genetic 1 1 1 Synthetic Growth Defect
VPS3 YDR495C Component of CORVET membrane tethering complex genetic 1 1 1 Synthetic Growth Defect
VPS36 YLR417W Component of the ESCRT-II complex genetic 1 1 1 Synthetic Growth Defect
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Synthetic Growth Defect
YDL218W YDL218W Putative protein of unknown function genetic 1 1 1 Synthetic Growth Defect
VTC5 YDR089W Novel subunit of the vacuolar transporter chaperone complex genetic 1 1 1 Synthetic Growth Defect
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 1 1 1 Synthetic Growth Defect
YML020W YML020W Putative protein of unknown function genetic 1 1 1 Synthetic Growth Defect
VPS13 YLL040C Lipid transport protein involved in prospore membrane morphogenesis genetic 1 1 1 Synthetic Growth Defect
VPS41 YDR080W Subunit of the HOPS endocytic tethering complex genetic 1 1 1 Synthetic Growth Defect
VPS62 YGR141W Vacuolar protein sorting (VPS) protein genetic 1 1 1 Synthetic Growth Defect
VPS73 YGL104C Mitochondrial protein genetic 1 1 1 Synthetic Growth Defect
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 1 1 1 Synthetic Growth Defect
YAP1801 YHR161C Protein of the AP180 family, involved in clathrin cage assembly genetic 1 1 1 Synthetic Growth Defect
YAR029W YAR029W Member of DUP240 gene family but contains no transmembrane domains genetic 1 1 1 Synthetic Growth Defect
YCR007C YCR007C Putative integral membrane protein genetic 1 1 1 Synthetic Growth Defect
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Synthetic Growth Defect
VMS1 YDR049W Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, genetic 1 1 1 Synthetic Growth Defect
YGR122W YGR122W Protein that may be involved in pH regulation genetic 1 1 1 Synthetic Growth Defect
YGR237C YGR237C Putative protein of unknown function genetic 1 1 1 Synthetic Growth Defect
YKL069W YKL069W Methionine-R-sulfoxide reductase genetic 1 1 1 Synthetic Growth Defect
YPR089W YPR089W Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
YUR1 YJL139C Mannosyltransferase involved in protein N-glycosylation genetic 1 1 1 Synthetic Growth Defect
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Synthetic Growth Defect
VPS72 YDR485C Htz1p-binding component of the SWR1 complex genetic 1 1 1 Synthetic Growth Defect
YAK1 YJL141C Serine-threonine protein kinase genetic 1 1 1 Synthetic Growth Defect
YBR284W YBR284W Putative metallo-dependent hydrolase superfamily protein genetic 1 1 1 Synthetic Growth Defect
YEH1 YLL012W Steryl ester hydrolase genetic 1 1 1 Synthetic Growth Defect
YND1 YER005W Apyrase with wide substrate specificity genetic 1 1 1 Synthetic Growth Defect
ZUO1 YGR285C Ribosome-associated chaperone genetic 1 1 1 Synthetic Growth Defect
VPS55 YJR044C Late endosomal protein involved in late endosome to vacuole transport genetic 1 1 1 Synthetic Growth Defect
VTA1 YLR181C Multivesicular body (MVB) protein genetic 1 1 1 Synthetic Growth Defect
VTS1 YOR359W Flap-structured DNA-binding and RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 1 1 1 Synthetic Growth Defect
ZRC1 YMR243C Vacuolar membrane zinc transporter genetic 1 1 1 Synthetic Growth Defect
YTH1 YPR107C Essential RNA-binding component of cleavage and polyadenylation factor genetic 1 1 1 Positive Genetic
YAL064W YAL064W Protein of unknown function genetic 1 1 1 Positive Genetic
YDR194W-A YDR194W-A Putative protein of unknown function genetic 1 1 1 Positive Genetic
VMA5 YKL080W Subunit C of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Positive Genetic
YKL107W YKL107W NADH-dependent aldehyde reductase genetic 1 1 1 Positive Genetic
YMR114C YMR114C Protein of unknown function genetic 1 1 1 Positive Genetic
YMR206W YMR206W Putative protein of unknown function genetic 1 1 1 Positive Genetic
YNL320W YNL320W Putative protein of unknown function genetic 1 1 1 Positive Genetic
WSC3 YOL105C Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway genetic 1 1 1 Positive Genetic
YOR032W-A YOR032W-A Protein of unknown function genetic 1 1 1 Positive Genetic
YPT1 YFL038C Rab family GTPase genetic 1 1 1 Negative Genetic
YKT6 YKL196C Vesicle membrane protein (v-SNARE) with acyltransferase activity genetic 1 1 1 Negative Genetic
WRS1 YOL097C Cytoplasmic tryptophanyl-tRNA synthetase genetic 1 1 1 Negative Genetic
YBR016W YBR016W Tail-anchored plasma membrane protein with a conserved CYSTM module genetic 1 1 1 Negative Genetic
YRO2 YBR054W Protein with a putative role in response to acid stress genetic 1 1 1 Negative Genetic
YBR096W YBR096W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YAT2 YER024W Carnitine acetyltransferase genetic 1 1 1 Negative Genetic
YIP4 YGL198W Protein that interacts with Rab GTPases genetic 1 1 1 Negative Genetic
YGL235W YGL235W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YHB1 YGR234W Nitric oxide oxidoreductase genetic 1 1 1 Negative Genetic
YHL008C YHL008C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YHL026C YHL026C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YHR050W-A YHR050W-A Protein of unknown function genetic 1 1 1 Negative Genetic
YJL107C YJL107C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YKR005C YKR005C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YEH2 YLR020C Steryl ester hydrolase genetic 1 1 1 Negative Genetic
YLR156C-A YLR156C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
VRP1 YLR337C Verprolin, proline-rich actin-associated protein genetic 1 1 1 Negative Genetic
YML037C YML037C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YML119W YML119W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YNL067W-B YNL067W-B Putative protein of unknown function genetic 1 1 1 Negative Genetic
YPT53 YNL093W Stress-induced Rab family GTPase genetic 1 1 1 Negative Genetic
YNL134C YNL134C NADH-dependent aldehyde reductase genetic 1 1 1 Negative Genetic
YNL208W YNL208W Protein of unknown function genetic 1 1 1 Negative Genetic
VPS68 YOL129W Vacuolar membrane protein of unknown function genetic 1 1 1 Negative Genetic
YOL155W-A YOL155W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 1 1 1 Negative Genetic
YOR072W-B YOR072W-B Putative protein of unknown function genetic 1 1 1 Negative Genetic
YOR376W-A YOR376W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
INP1 YMR204C Peripheral membrane protein of peroxisomes genetic 1 1 1 Negative Genetic
BAP3 YDR046C Amino acid permease genetic 1 1 1 Negative Genetic
CFD1 YIL003W Highly conserved iron-sulfur cluster binding protein genetic 1 1 1 Negative Genetic
GDA1 YEL042W Guanosine diphosphatase located in the Golgi genetic 1 1 1 Negative Genetic
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Positive Genetic
KEX1 YGL203C Cell death protease essential for hypochlorite-induced apoptosis genetic 1 1 1 Synthetic Growth Defect
RPL40A YIL148W Ubiquitin-ribosomal 60S subunit protein L40A fusion protein genetic 1 1 1 Negative Genetic
RPL40B YKR094C Ubiquitin-ribosomal 60S subunit protein L40B fusion protein genetic 1 1 1 Negative Genetic
PAH1 YMR165C Mg2+-dependent phosphatidate (PA) phosphatase genetic 1 1 1 Synthetic Growth Defect
CUE1 YMR264W Ubiquitin-binding protein genetic 1 1 1 Synthetic Growth Defect
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 1 1 1 Synthetic Growth Defect
SAT4 YCR008W Ser/Thr protein kinase involved in salt tolerance, nutrient response genetic 1 1 1 Synthetic Growth Defect
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Synthetic Growth Defect
EKI1 YDR147W Ethanolamine kinase genetic 1 1 1 Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Synthetic Growth Defect
MRPL17 YNL252C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex genetic 1 1 1 Negative Genetic
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Negative Genetic
STP1 YDR463W Transcription factor genetic 1 1 1 Synthetic Growth Defect
SLF1 YDR515W RNA binding protein that associates with polysomes genetic 1 1 1 Positive Genetic
FPR2 YDR519W Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase) physical 1 1 1 Affinity Capture-MS
ISD11 YER048W-A Cysteine desulfurase (Nfs1p) activator genetic 1 1 1 Positive Genetic
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Synthetic Growth Defect
UBP2 YOR124C Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
RIM8 YGL045W Protein involved in proteolytic activation of Rim101p genetic 1 1 1 Synthetic Growth Defect
NEL1 YHR035W Activator of Sar1p GTPase activity genetic 1 1 1 Negative Genetic
VID28 YIL017C GID Complex subunit, serves as adaptor for regulatory subunit Vid24p genetic 1 1 1 Positive Genetic
PSD2 YGR170W Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes genetic 1 1 1 Synthetic Growth Defect
RRP15 YPR143W Nucleolar protein genetic 1 1 1 Negative Genetic
LYS14 YDR034C Transcriptional activator involved in regulating lysine biosynthesis genetic 1 1 1 Synthetic Growth Defect
HOB2 YPR117W Protein with structural similarity to lipid transport protein Vps13p genetic 1 1 1 Negative Genetic
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 1 1 1 Synthetic Growth Defect
VHS2 YIL135C Regulator of septin dynamics genetic 1 1 1 Synthetic Growth Defect
RPP1A YDL081C Ribosomal stalk protein P1 alpha genetic 1 1 1 Synthetic Growth Defect
LAM1 YHR155W Putative sterol transfer protein genetic 1 1 1 Negative Genetic
ELF1 YKL160W Transcription elongation factor with a conserved zinc finger domain genetic 1 1 1 Synthetic Growth Defect
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Synthetic Growth Defect
CYK3 YDL117W SH3-domain protein located in the bud neck and cytokinetic actin ring genetic 1 1 1 Synthetic Growth Defect
KAE1 YKR038C Highly conserved ATPase of HSP70/DnaK family genetic 1 1 1 Negative Genetic
SIS2 YKR072C Negative regulatory subunit of protein phosphatase 1 (Ppz1p) genetic 1 1 1 Synthetic Growth Defect
RTT109 YLL002W Histone acetyltransferase genetic 1 1 1 Synthetic Growth Defect
SLX4 YLR135W Endonuclease involved in processing DNA genetic 1 1 1 Negative Genetic
VAC14 YLR386W Enzyme regulator genetic 1 1 1 Synthetic Growth Defect
CAJ1 YER048C Nuclear type II J heat shock protein of the E. coli dnaJ family genetic 1 1 1 Synthetic Growth Defect
PSP2 YML017W Asn rich cytoplasmic protein that contains RGG motifs genetic 1 1 1 Synthetic Growth Defect
UBX4 YMR067C UBX domain-containing protein that interacts with Cdc48p genetic 1 1 1 Synthetic Growth Defect
PKR1 YMR123W V-ATPase assembly factor physical 1 1 1 PCA
POC4 YPL144W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 1 1 1 Synthetic Growth Defect
UBP14 YBR058C Ubiquitin-specific protease genetic 1 1 1 Synthetic Growth Defect
UBP10 YNL186W Ubiquitin-specific protease, deubiquitinates Ub-protein moieties genetic 1 1 1 Negative Genetic
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-RNA
GTT3 YEL017W Protein of unknown function may be involved in glutathione metabolism genetic 1 1 1 Negative Genetic
GLN4 YOR168W Glutamine tRNA synthetase genetic 1 1 1 Negative Genetic
LIP5 YOR196C Protein involved in biosynthesis of the coenzyme lipoic acid genetic 1 1 1 Synthetic Growth Defect
NPT1 YOR209C Nicotinate phosphoribosyltransferase genetic 1 1 1 Synthetic Growth Defect
ALD4 YOR374W Mitochondrial aldehyde dehydrogenase genetic 1 1 1 Positive Genetic
IRC25 YLR021W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 1 1 1 Synthetic Growth Defect
ROX1 YPR065W Heme-dependent repressor of hypoxic genes genetic 1 1 1 Synthetic Rescue
TRS31 YDR472W Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Negative Genetic
KRE28 YDR532C Subunit of a kinetochore-microtubule binding complex genetic 1 1 1 Synthetic Growth Defect
CWH41 YGL027C Processing alpha glucosidase I genetic 1 1 1 Synthetic Growth Defect
PET130 YJL023C Protein of unknown function genetic 1 1 1 Positive Genetic
LAP3 YNL239W Cysteine aminopeptidase with homocysteine-thiolactonase activity genetic 1 1 1 Negative Genetic
IRC19 YLL033W Protein of unknown function genetic 1 1 1 Positive Genetic
TUB3 YML124C Alpha-tubulin genetic 1 1 1 Negative Genetic
TUB2 YFL037W Beta-tubulin genetic 1 1 1 Negative Genetic
ERP3 YDL018C Protein with similarity to Emp24p and Erv25p genetic 1 1 1 Synthetic Growth Defect
RPL13B YMR142C Ribosomal 60S subunit protein L13B genetic 1 1 1 Synthetic Growth Defect
SPB4 YFL002C Putative ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
GSH1 YJL101C Gamma glutamylcysteine synthetase genetic 1 1 1 Synthetic Growth Defect
CHS6 YJL099W Member of the ChAPs (Chs5p-Arf1p-binding proteins) family genetic 1 1 1 Synthetic Growth Defect
DPH5 YLR172C Methyltransferase required for synthesis of diphthamide genetic 1 1 1 Synthetic Growth Defect
OCA5 YHL029C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Synthetic Growth Defect
SQS1 YNL224C Protein that stimulates the ATPase and helicase activities of Prp43p genetic 1 1 1 Synthetic Growth Defect
GVP36 YIL041W BAR domain protein that localizes to early and late Golgi vesicles genetic 1 1 1 Synthetic Growth Defect
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 1 1 1 Negative Genetic
GCS1 YDL226C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 1 1 1 Synthetic Growth Defect
BST1 YFL025C GPI inositol deacylase of the endoplasmic reticulum (ER) genetic 1 1 1 Synthetic Growth Defect
ARO2 YGL148W Bifunctional chorismate synthase and flavin reductase genetic 1 1 1 Synthetic Growth Defect
RPS29B YDL061C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
ATG21 YPL100W Phosphoinositide binding protein genetic 1 1 1 Synthetic Growth Defect
FPS1 YLL043W Aquaglyceroporin, plasma membrane channel genetic 1 1 1 Synthetic Growth Defect
PTK2 YJR059W Serine/threonine protein kinase genetic 1 1 1 Synthetic Growth Defect
NMT1 YLR195C N-myristoyl transferase genetic 1 1 1 Negative Genetic
PTP1 YDL230W Phosphotyrosine-specific protein phosphatase genetic 1 1 1 Negative Genetic
PIK1 YNL267W Phosphatidylinositol 4-kinase genetic 1 1 1 Negative Genetic
GUP1 YGL084C Plasma membrane protein involved in remodeling GPI anchors genetic 1 1 1 Synthetic Growth Defect
RUD3 YOR216C Golgi matrix protein genetic 1 1 1 Synthetic Growth Defect
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Negative Genetic
PGA2 YNL149C Essential protein required for maturation of Gas1p and Pho8p genetic 1 1 1 Negative Genetic
SYG1 YIL047C Plasma membrane protein of unknown function genetic 1 1 1 Positive Genetic
SKG1 YKR100C Transmembrane protein with a role in cell wall polymer composition genetic 1 1 1 Synthetic Growth Defect
LCL1 YPL056C Putative protein of unknown function genetic 1 1 1 Synthetic Growth Defect
SIT1 YEL065W Ferrioxamine B transporter genetic 1 1 1 Synthetic Growth Defect
ALG6 YOR002W ER-luminal alpha 1,3 glucosyltransferase genetic 1 1 1 Synthetic Growth Defect
UTP25 YIL091C Nucleolar protein genetic 1 1 1 Negative Genetic
UBX5 YDR330W UBX domain-containing protein that interacts with Cdc48p genetic 1 1 1 Positive Genetic
SET4 YJL105W Chromatin-associated protein involved in control of stress response genetic 1 1 1 Positive Genetic
TRP1 YDR007W Phosphoribosylanthranilate isomerase genetic 1 1 1 Synthetic Growth Defect
SMF1 YOL122C Divalent metal ion transporter genetic 1 1 1 Synthetic Growth Defect
RPS27B YHR021C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
DER1 YBR201W ER membrane protein that promotes export of misfolded polypeptides genetic 1 1 1 Negative Genetic
MNN2 YBR015C Alpha-1,2-mannosyltransferase genetic 1 1 1 Synthetic Growth Defect
KTR1 YOR099W Alpha-1,2-mannosyltransferase genetic 1 1 1 Negative Genetic
LIP1 YMR298W Ceramide synthase subunit genetic 1 1 1 Negative Genetic
DNF2 YDR093W Aminophospholipid translocase (flippase) genetic 1 1 1 Negative Genetic
CDC50 YCR094W Endosomal protein that interacts with phospholipid flippase Drs2p genetic 1 1 1 Synthetic Growth Defect
RRT2 YBR246W Methylesterase performing penultimate step of diphthamide biosynthesis genetic 1 1 1 Synthetic Growth Defect
CTA1 YDR256C Catalase A genetic 1 1 1 Negative Genetic
PEX31 YGR004W Peroxisomal integral membrane protein genetic 1 1 1 Synthetic Growth Defect
THR1 YHR025W Homoserine kinase genetic 1 1 1 Synthetic Growth Defect
QNS1 YHR074W Glutamine-dependent NAD(+) synthetase genetic 1 1 1 Positive Genetic
RIM13 YMR154C Calpain-like cysteine protease genetic 1 1 1 Negative Genetic
JJJ3 YJR097W Iron-binding protein genetic 1 1 1 Synthetic Growth Defect
TVP15 YDR100W Integral membrane protein genetic 1 1 1 Negative Genetic
MDM34 YGL219C Mitochondrial component of the ERMES complex genetic 1 1 1 Synthetic Growth Defect
RPL22B YFL034C-A Ribosomal 60S subunit protein L22A genetic 1 1 1 Synthetic Growth Defect
RPS16B YDL083C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
TIM54 YJL054W Component of the mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain genetic 1 1 1 Synthetic Growth Defect
KIP3 YGL216W Kinesin-related antiparallel sliding motor protein genetic 1 1 1 Negative Genetic
SHE1 YBL031W Mitotic spindle protein genetic 1 1 1 Synthetic Growth Defect
SLI15 YBR156C Subunit of the conserved chromosomal passenger complex (CPC) genetic 1 1 1 Negative Genetic
SOK2 YMR016C Nuclear protein that negatively regulates pseudohyphal differentiation genetic 1 1 1 Synthetic Growth Defect
SDD4 YPR022C Putative transcription factor, as suggested by computational analysis genetic 1 1 1 Negative Genetic
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 1 1 1 Negative Genetic
TCB3 YML072C Cortical ER protein involved in ER-plasma membrane tethering genetic 1 1 1 Negative Genetic
PMC1 YGL006W Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions genetic 1 1 1 Synthetic Growth Defect
GPX2 YBR244W Phospholipid hydroperoxide glutathione peroxidase genetic 1 1 1 Negative Genetic
GRX3 YDR098C Glutathione-dependent oxidoreductase genetic 1 1 1 Negative Genetic
BAP2 YBR068C High-affinity leucine permease genetic 1 1 1 Synthetic Growth Defect
ILM1 YJR118C Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
RTC1 YOL138C Subunit of SEACAT, a subcomplex of the SEA complex genetic 1 1 1 Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 1 1 1 Synthetic Growth Defect
ADK2 YER170W Mitochondrial adenylate kinase genetic 1 1 1 Negative Genetic
MRX6 YNL295W Mitochondrial ribosome-associated protein genetic 1 1 1 Negative Genetic
SFB3 YHR098C Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat genetic 1 1 1 Negative Genetic
GPI13 YLL031C ER membrane localized phosphoryltransferase genetic 1 1 1 Positive Genetic
CCW12 YLR110C Cell wall mannoprotein genetic 1 1 1 Synthetic Growth Defect
KRE1 YNL322C Cell wall glycoprotein involved in beta-glucan assembly genetic 1 1 1 Synthetic Growth Defect
TPI1 YDR050C Triose phosphate isomerase, abundant glycolytic enzyme genetic 1 1 1 Negative Genetic
ARO7 YPR060C Chorismate mutase genetic 1 1 1 Synthetic Growth Defect
TAE1 YBR261C AdoMet-dependent proline methyltransferase genetic 1 1 1 Synthetic Growth Defect
ATG15 YCR068W Phospholipase genetic 1 1 1 Synthetic Growth Defect
RPE1 YJL121C D-ribulose-5-phosphate 3-epimerase genetic 1 1 1 Negative Genetic
GPI14 YJR013W Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I genetic 1 1 1 Negative Genetic
MTC2 YKL098W Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
EDS1 YBR033W Putative zinc cluster protein, predicted to be a transcription factor genetic 1 1 1 Negative Genetic
BSC4 YNL269W Protein of unknown function genetic 1 1 1 Negative Genetic
AIM14 YGL160W NADPH oxidase localized to the perinuclear ER genetic 1 1 1 Synthetic Growth Defect
PAI3 YMR174C Cytoplasmic proteinase A (Pep4p) inhibitor genetic 1 1 1 Positive Genetic
RMD8 YFR048W Cytosolic protein required for sporulation genetic 1 1 1 Synthetic Growth Defect
SMF3 YLR034C Putative divalent metal ion transporter involved in iron homeostasis genetic 1 1 1 Synthetic Growth Defect
STE24 YJR117W Highly conserved zinc metalloprotease genetic 1 1 1 Negative Genetic
TVS1 YCR061W Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
NSG2 YNL156C Protein involved in regulation of sterol biosynthesis genetic 1 1 1 Negative Genetic
TMA17 YDL110C Regulatory gamma subunit of fatty acid synthase (FAS) genetic 1 1 1 Synthetic Growth Defect
SCW10 YMR305C Cell wall protein with similarity to glucanases genetic 1 1 1 Synthetic Growth Defect
GPM3 YOL056W Nonfunctional homolog of Gpm1p phosphoglycerate mutase genetic 1 1 1 Negative Genetic
RPO41 YFL036W Mitochondrial RNA polymerase genetic 1 1 1 Synthetic Growth Defect
NCS2 YNL119W Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs genetic 1 1 1 Synthetic Growth Defect
NCS6 YGL211W Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs genetic 1 1 1 Synthetic Growth Defect
RPL12B YDR418W Ribosomal 60S subunit protein L12B genetic 1 1 1 Negative Genetic
RPS6B YBR181C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
CCC2 YDR270W Cu(+2)-transporting P-type ATPase genetic 1 1 1 Synthetic Growth Defect
TDA5 YLR426W Putative protein of unknown function genetic 1 1 1 Negative Genetic
NAT4 YMR069W N alpha-acetyl-transferase genetic 1 1 1 Positive Genetic
MIC12 YBR262C Component of the MICOS complex genetic 1 1 1 Negative Genetic
EMC10 YDR056C Putative protein of unknown function genetic 1 1 1 Negative Genetic
MSC1 YML128C Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
MZM1 YDR493W Protein required for assembly of the cytochrome bc(1) complex genetic 1 1 1 Negative Genetic
LMO1 YLL007C Homolog of mammalian ELMO (Engulfment and celL MOtility) genetic 1 1 1 Negative Genetic
MAL33 YBR297W MAL-activator protein genetic 1 1 1 Positive Genetic
GPI15 YNL038W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Positive Genetic
CDC1 YDR182W Putative mannose-ethanolamine phosphate phosphodiesterase genetic 1 1 1 Negative Genetic
APS3 YJL024C Small subunit of the clathrin-associated adaptor complex AP-3 genetic 1 1 1 Synthetic Growth Defect
GSH2 YOL049W Glutathione synthetase genetic 1 1 1 Synthetic Growth Defect
LIP2 YLR239C Lipoyl ligase genetic 1 1 1 Synthetic Growth Defect
DLT1 YMR126C Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
AVT7 YIL088C Vacuolar amino acid transporter genetic 1 1 1 Synthetic Growth Defect
IRC15 YPL017C Microtubule associated protein genetic 1 1 1 Negative Genetic
SAM3 YPL274W High-affinity S-adenosylmethionine permease genetic 1 1 1 Negative Genetic
ALG11 YNL048W Alpha-1,2-mannosyltransferase genetic 1 1 1 Negative Genetic
GUP2 YPL189W Probable membrane protein genetic 1 1 1 Positive Genetic
ROT2 YBR229C Glucosidase II catalytic subunit genetic 1 1 1 Synthetic Growth Defect
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex genetic 1 1 1 Negative Genetic
NHX1 YDR456W Na+/H+ and K+/H+ exchanger genetic 1 1 1 Synthetic Growth Defect
SEO1 YAL067C Putative permease genetic 1 1 1 Negative Genetic
LDS1 YAL018C Protein Involved in spore wall assembly genetic 1 1 1 Negative Genetic
PER1 YCR044C Protein of the endoplasmic reticulum genetic 1 1 1 Synthetic Growth Defect
CNE1 YAL058W Calnexin genetic 1 1 1 Synthetic Growth Defect
ALG8 YOR067C Glucosyl transferase genetic 1 1 1 Synthetic Growth Defect
SPC3 YLR066W Subunit of signal peptidase complex genetic 1 1 1 Negative Genetic
SPE1 YKL184W Ornithine decarboxylase genetic 1 1 1 Synthetic Growth Defect
CBT1 YKL208W Protein involved in 5' RNA end processing genetic 1 1 1 Negative Genetic
SDH8 YBR269C Protein required for assembly of succinate dehydrogenase genetic 1 1 1 Synthetic Growth Defect
RPL41B YDL133C-A Ribosomal 60S subunit protein L41B genetic 1 1 1 Synthetic Growth Defect
RPS21B YJL136C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
RPS28B YLR264W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
PGA3 YML125C Putative cytochrome b5 reductase, localized to the plasma membrane genetic 1 1 1 Negative Genetic
SER2 YGR208W Phosphoserine phosphatase of the phosphoglycerate pathway genetic 1 1 1 Synthetic Growth Defect
MET22 YOL064C Bisphosphate-3'-nucleotidase genetic 1 1 1 Synthetic Growth Defect
SNA2 YDR525W-A Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
OCT1 YKL134C Mitochondrial intermediate peptidase genetic 1 1 1 Synthetic Growth Defect
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 1 1 1 Synthetic Growth Defect
RKR1 YMR247C RING domain E3 ubiquitin ligase genetic 1 1 1 Synthetic Growth Defect
LST4 YKL176C Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p genetic 1 1 1 Synthetic Growth Defect
URM1 YIL008W Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs genetic 1 1 1 Synthetic Growth Defect
MRX8 YDR336W Protein that associates with mitochondrial ribosome genetic 1 1 1 Synthetic Growth Defect
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 1 1 1 Synthetic Growth Defect
SPP41 YDR464W Protein of unknown function genetic 1 1 1 Negative Genetic
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Positive Genetic
PET117 YER058W Assembly factor that couples heme a synthesis to complex IV assembly genetic 1 1 1 Negative Genetic
ARG2 YJL071W Acetylglutamate synthase (glutamate N-acetyltransferase) genetic 1 1 1 Synthetic Growth Defect
SIM1 YIL123W Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) genetic 1 1 1 Synthetic Growth Defect
SWP82 YFL049W Member of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
PPM1 YDR435C Carboxyl methyltransferase genetic 1 1 1 Synthetic Growth Defect
RRF1 YHR038W Mitochondrial ribosome recycling factor genetic 1 1 1 Synthetic Growth Defect
MRX4 YPL168W Protein that associates with mitochondrial ribosome genetic 1 1 1 Synthetic Growth Defect
UPF3 YGR072W Component of the nonsense-mediated mRNA decay (NMD) pathway genetic 1 1 1 Synthetic Growth Defect
THR4 YCR053W Threonine synthase genetic 1 1 1 Synthetic Growth Defect
DML1 YMR211W Essential protein involved in mtDNA inheritance genetic 1 1 1 Negative Genetic
SPF1 YEL031W P-type ATPase, ion transporter of the ER membrane genetic 1 1 1 Synthetic Growth Defect
TDA4 YJR116W Protein distantly similar to ceramide synthases, Lag1p and Lac1p genetic 1 1 1 Synthetic Growth Defect
ARG7 YMR062C Mitochondrial ornithine acetyltransferase genetic 1 1 1 Synthetic Growth Defect
TRK1 YJL129C Component of the Trk1p-Trk2p potassium transport system genetic 1 1 1 Synthetic Growth Defect
MAY24 YPR153W Peripheral ER membrane protein genetic 1 1 1 Synthetic Growth Defect
TOM6 YOR045W Component of the TOM (translocase of outer membrane) complex genetic 1 1 1 Negative Genetic
GRX8 YLR364W Glutaredoxin that employs a dithiol mechanism of catalysis genetic 1 1 1 Positive Genetic
MTC6 YHR151C Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
UBC5 YDR059C Ubiquitin-conjugating enzyme genetic 1 1 1 Negative Genetic
TMA23 YMR269W Nucleolar protein implicated in ribosome biogenesis genetic 1 1 1 Synthetic Growth Defect
TOS2 YGR221C Protein involved in localization of Cdc24p to the site of bud growth genetic 1 1 1 Synthetic Growth Defect
TUF1 YOR187W Mitochondrial translation elongation factor Tu (EF-Tu) genetic 1 1 1 Synthetic Growth Defect
UPS3 YDR185C Mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
ASP3-3 YLR158C Cell-wall L-asparaginase II involved in asparagine catabolism genetic 1 1 1 Negative Genetic
TRP4 YDR354W Anthranilate phosphoribosyl transferase genetic 1 1 1 Synthetic Growth Defect
URA4 YLR420W Dihydroorotase genetic 1 1 1 Synthetic Growth Defect
RTR2 YDR066C Protein of unknown function genetic 1 1 1 Negative Genetic
MIN10 YFR032C-B Mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
PAU16 YKL224C Protein of unknown function genetic 1 1 1 Negative Genetic
TPT1 YOL102C tRNA 2'-phosphotransferase that catalyzes final step in tRNA splicing genetic 1 1 1 Negative Genetic
PAU14 YIL176C Protein of unknown function genetic 1 1 1 Negative Genetic