Standard name Systematic name Name description Description
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p UBX domain-containing substrate adaptor for Cdc48p; ubiquitin regulatory X domain-containing protein that acts as a substrate recruiting cofactor for Cdc48p; positively regulates Glc7p PPase activity to promote growth and mitotic progression in complex with Cdc48p; ubiquitinated protein interactor involved in ER-associated degradation (ERAD); regulated by nuclear Ub-dependent degradation (INMAD pathway) independent of the Asi and Doa10 complexes; homolog of human p47 (NSFL1C)
Visualize the interactome of SHP1
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.198 0.582 0.301
Nucleus 0.072 NaN 0.087
Vac/Vac Memb 0.778 0.571 0.702

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 3200

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SHP1 5 2 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
CDC48 YDL126C AAA ATPase with protein-unfoldase activity physical 24 5 14 Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-Western, Co-crystal Structure, Affinity Capture-MS, Affinity Capture-Western
UFD2 YDL190C Ubiquitin (Ub) chain assembly factor (E4) physical 6 4 5 Affinity Capture-MS, Co-purification, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation physical 6 3 5 Affinity Capture-MS, Co-purification, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 5 1 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
UBI4 YLL039C Ubiquitin physical 5 4 3 Two-hybrid, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit physical 5 2 3 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 4 2 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 4 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
SGF11 YPL047W Integral subunit of SAGA histone acetyltransferase complex genetic 4 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 4 4 3 Synthetic Rescue, Synthetic Lethality, Dosage Rescue, Negative Genetic
MAD2 YJL030W Component of the spindle-assembly checkpoint complex genetic 4 3 3 Negative Genetic, Phenotypic Suppression, Synthetic Growth Defect, Negative Genetic
IPL1 YPL209C Aurora kinase of chromosomal passenger complex genetic 4 3 3 Dosage Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression
GLC8 YMR311C Regulatory subunit of protein phosphatase 1 (Glc7p) genetic 4 3 1 Synthetic Lethality, Dosage Rescue, Dosage Rescue, Dosage Growth Defect
FKH1 YIL131C Forkhead family transcription factor regulation 3 2 3 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 3 2 3 Negative Genetic, Synthetic Haploinsufficiency, Negative Genetic
ASF1 YJL115W Nucleosome assembly factor genetic 3 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 3 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 3 2 3 Negative Genetic, Synthetic Rescue, Negative Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 3 2 3 Phenotypic Enhancement, Negative Genetic, Negative Genetic
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) genetic 3 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 3 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic
CSF1 YLR087C Protein with structural similarity to lipid transport protein Vps13p genetic 3 2 3 Negative Genetic, Negative Genetic, Positive Genetic
CUZ1 YNL155W Protein with a role in the ubiquitin-proteasome pathway physical 3 2 3 Affinity Capture-MS, Two-hybrid, Affinity Capture-MS
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SGF29 YCL010C Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
DSK2 YMR276W Nuclear-enriched ubiquitin-like polyubiquitin-binding protein genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
MAD1 YGL086W Coiled-coil protein involved in spindle-assembly checkpoint genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CIN1 YOR349W Tubulin folding factor D involved in beta-tubulin (Tub2p) folding genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
MON1 YGL124C Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SAM37 YMR060C Component of the Sorting and Assembly Machinery (SAM) complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
VMS1 YDR049W Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, genetic 3 3 2 Phenotypic Enhancement, Synthetic Growth Defect, Positive Genetic
OTU1 YFL044C Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p physical 3 3 2 Reconstituted Complex, Affinity Capture-Western, Two-hybrid
SDS22 YKL193C Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p physical 3 2 2 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
YPI1 YFR003C Regulatory subunit of the type I protein phosphatase (PP1) Glc7p physical 3 2 2 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 3 2 2 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
ATG8 YBL078C Ub-like protein physical 3 3 1 PCA, Affinity Capture-Western, Reconstituted Complex
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 2 2 2 Negative Genetic, Synthetic Rescue
DAM1 YGR113W Essential subunit of the Dam1 complex (aka DASH complex) genetic 2 2 2 Dosage Rescue, Negative Genetic
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 2 2 2 Synthetic Lethality, Negative Genetic
ZRT1 YGL255W High-affinity zinc transporter of the plasma membrane genetic 2 2 2 Negative Genetic, Positive Genetic
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 2 2 2 Negative Genetic, Synthetic Rescue
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 2 2 2 Negative Genetic, Synthetic Lethality
ELO3 YLR372W Elongase genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 2 2 2 Negative Genetic, Dosage Growth Defect
CHL4 YDR254W Outer kinetochore protein required for chromosome stability genetic 2 1 2 Negative Genetic, Negative Genetic
CTF19 YPL018W Outer kinetochore protein, needed for accurate chromosome segregation genetic 2 1 2 Negative Genetic, Negative Genetic
NKP1 YDR383C Central kinetochore protein and subunit of the Ctf19 complex genetic 2 1 2 Negative Genetic, Negative Genetic
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 2 1 2 Negative Genetic, Negative Genetic
MCM21 YDR318W Component of the kinetochore sub-complex COMA genetic 2 1 2 Negative Genetic, Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 2 1 2 Negative Genetic, Negative Genetic
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 2 1 2 Negative Genetic, Negative Genetic
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex genetic 2 1 2 Negative Genetic, Negative Genetic
FPR1 YNL135C Peptidyl-prolyl cis-trans isomerase (PPIase) genetic 2 1 2 Negative Genetic, Negative Genetic
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase genetic 2 1 2 Negative Genetic, Negative Genetic
GCN1 YGL195W Positive regulator of the Gcn2p kinase activity genetic 2 1 2 Negative Genetic, Negative Genetic
LSM7 YNL147W Lsm (Like Sm) protein genetic 2 1 2 Positive Genetic, Positive Genetic
ATG3 YNR007C E2-like enzyme genetic 2 1 2 Negative Genetic, Negative Genetic
LAT1 YNL071W Dihydrolipoamide acetyltransferase component (E2) of the PDC physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PUB1 YNL016W Poly (A)+ RNA-binding protein genetic 2 1 2 Negative Genetic, Negative Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 2 1 2 Negative Genetic, Negative Genetic
PPH21 YDL134C Catalytic subunit of protein phosphatase 2A, PP2A genetic 2 1 2 Negative Genetic, Negative Genetic
NUM1 YDR150W Protein required for nuclear migration genetic 2 1 2 Negative Genetic, Negative Genetic
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 2 1 2 Negative Genetic, Negative Genetic
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 2 1 2 Negative Genetic, Negative Genetic
NEW1 YPL226W Translation termination and ribosome biogenesis factor genetic 2 1 2 Negative Genetic, Negative Genetic
RGC1 YPR115W Putative regulator of the Fps1p glycerol channel genetic 2 1 2 Negative Genetic, Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 2 1 2 Negative Genetic, Negative Genetic
PPQ1 YPL179W Protein phosphatase that regulates the mating response physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
FET3 YMR058W Ferro-O2-oxidoreductase genetic 2 1 2 Negative Genetic, Negative Genetic
PPZ2 YDR436W Serine/threonine protein phosphatase Z, isoform of Ppz1p physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
KNS1 YLL019C Protein kinase involved in negative regulation of PolIII transcription genetic 2 1 2 Negative Genetic, Negative Genetic
UBX4 YMR067C UBX domain-containing protein that interacts with Cdc48p genetic 2 1 2 Negative Genetic, Negative Genetic
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 2 1 2 Positive Genetic, Positive Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 2 1 2 Negative Genetic, Negative Genetic
SWM1 YDR260C Subunit of the anaphase-promoting complex (APC) genetic 2 1 2 Negative Genetic, Negative Genetic
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 2 1 2 Negative Genetic, Negative Genetic
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 2 1 2 Negative Genetic, Negative Genetic
SLX9 YGR081C Protein required for pre-rRNA processing genetic 2 1 2 Negative Genetic, Negative Genetic
UBR1 YGR184C E3 ubiquitin ligase (N-recognin) genetic 2 1 2 Negative Genetic, Negative Genetic
SMF2 YHR050W Divalent metal ion transporter involved in manganese homeostasis genetic 2 1 2 Negative Genetic, Negative Genetic
YIR042C YIR042C Putative protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
YAK1 YJL141C Serine-threonine protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
SSK1 YLR006C Cytoplasmic phosphorelay intermediate osmosensor and regulator genetic 2 1 2 Negative Genetic, Negative Genetic
UBR2 YLR024C Cytoplasmic ubiquitin-protein ligase (E3) genetic 2 1 2 Positive Genetic, Positive Genetic
SRN2 YLR119W Component of the ESCRT-I complex genetic 2 1 2 Negative Genetic, Negative Genetic
YLR126C YLR126C Putative glutamine amidotransferase genetic 2 1 2 Negative Genetic, Negative Genetic
THI7 YLR237W Plasma membrane transporter responsible for the uptake of thiamine genetic 2 1 2 Negative Genetic, Negative Genetic
VAC14 YLR386W Enzyme regulator genetic 2 1 2 Negative Genetic, Negative Genetic
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
YNR029C YNR029C Putative protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
STI1 YOR027W Evolutionarily-conserved Hsp90 cochaperone genetic 2 1 2 Negative Genetic, Negative Genetic
SLK19 YOR195W Kinetochore-associated protein genetic 2 1 2 Negative Genetic, Negative Genetic
VIK1 YPL253C Protein that forms a kinesin-14 heterodimeric motor with Kar3p genetic 2 1 2 Negative Genetic, Negative Genetic
ULA1 YPL003W Protein that activates Rub1p (NEDD8) before neddylation genetic 2 1 2 Negative Genetic, Negative Genetic
THI22 YPR121W Protein with similarity to hydroxymethylpyrimidine phosphate kinases genetic 2 1 2 Negative Genetic, Negative Genetic
HIR2 YOR038C Subunit of HIR nucleosome assembly complex genetic 2 1 2 Negative Genetic, Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 2 1 2 Negative Genetic, Negative Genetic
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 2 1 2 Negative Genetic, Negative Genetic
ASR1 YPR093C Ubiquitin ligase that modifies and regulates RNA Pol II genetic 2 1 2 Negative Genetic, Negative Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 2 1 2 Negative Genetic, Negative Genetic
PPZ1 YML016C Serine/threonine protein phosphatase Z, isoform of Ppz2p physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PPZ1 YML016C Serine/threonine protein phosphatase Z, isoform of Ppz2p genetic 2 1 2 Negative Genetic, Negative Genetic
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 2 1 2 Negative Genetic, Negative Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 1 2 Negative Genetic, Negative Genetic
GZF3 YJL110C GATA zinc finger protein genetic 2 1 2 Negative Genetic, Negative Genetic
OCA2 YNL056W Protein of unknown function genetic 2 1 2 Positive Genetic, Positive Genetic
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 2 1 2 Negative Genetic, Negative Genetic
CRP1 YHR146W Protein that binds to cruciform DNA structures genetic 2 1 2 Negative Genetic, Negative Genetic
NHP6A YPR052C High-mobility group (HMG) protein genetic 2 1 2 Negative Genetic, Negative Genetic
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 2 1 2 Negative Genetic, Negative Genetic
HOS1 YPR068C Class I histone deacetylase (HDAC) family member genetic 2 1 2 Negative Genetic, Negative Genetic
KAR3 YPR141C Minus-end-directed microtubule motor genetic 2 1 2 Negative Genetic, Negative Genetic
BIK1 YCL029C Microtubule-associated protein genetic 2 1 2 Negative Genetic, Negative Genetic
PHO80 YOL001W Cyclin genetic 2 1 2 Negative Genetic, Negative Genetic
JNM1 YMR294W Component of the yeast dynactin complex genetic 2 1 2 Negative Genetic, Negative Genetic
GAL80 YML051W Transcriptional regulator involved in the repression of GAL genes genetic 2 1 2 Negative Genetic, Negative Genetic
CAT8 YMR280C Zinc cluster transcriptional activator genetic 2 1 2 Negative Genetic, Negative Genetic
DPH6 YLR143W Diphthamide synthetase genetic 2 1 2 Negative Genetic, Negative Genetic
MRI1 YPR118W 5'-methylthioribose-1-phosphate isomerase genetic 2 1 2 Negative Genetic, Negative Genetic
NIP100 YPL174C Large subunit of the dynactin complex genetic 2 1 2 Negative Genetic, Negative Genetic
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 2 1 2 Positive Genetic, Positive Genetic
CLB3 YDL155W B-type cyclin involved in cell cycle progression genetic 2 1 2 Negative Genetic, Negative Genetic
RPL29 YFR032C-A Ribosomal 60S subunit protein L29 genetic 2 1 2 Negative Genetic, Negative Genetic
POG1 YIL122W DNA-binding transcriptional activator genetic 2 1 2 Negative Genetic, Negative Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 2 1 2 Negative Genetic, Negative Genetic
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component genetic 2 1 2 Negative Genetic, Negative Genetic
NKP2 YLR315W Central kinetochore protein and subunit of the Ctf19 complex genetic 2 1 2 Negative Genetic, Negative Genetic
MVB12 YGR206W ESCRT-I subunit required to stabilize ESCRT-I core complex oligomers genetic 2 1 2 Negative Genetic, Negative Genetic
RTT109 YLL002W Histone acetyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
MRS2 YOR334W Mitochondrial inner membrane Mg(2+) channel genetic 2 1 2 Negative Genetic, Negative Genetic
RPL8A YHL033C Ribosomal 60S subunit protein L8A genetic 2 1 2 Negative Genetic, Negative Genetic
RPL43A YPR043W Ribosomal 60S subunit protein L43A genetic 2 1 2 Negative Genetic, Negative Genetic
OPY2 YPR075C Integral membrane protein that acts as a membrane anchor for Ste50p genetic 2 1 2 Negative Genetic, Negative Genetic
CMR3 YPR013C Putative zinc finger protein genetic 2 1 2 Negative Genetic, Negative Genetic
HUR1 YGL168W Protein with a role in DNA repair genetic 2 1 2 Negative Genetic, Negative Genetic
EOS1 YNL080C Protein involved in N-glycosylation genetic 2 1 2 Negative Genetic, Negative Genetic
KIP3 YGL216W Kinesin-related antiparallel sliding motor protein genetic 2 1 2 Negative Genetic, Negative Genetic
LDB18 YLL049W Component of the dynactin complex genetic 2 1 2 Negative Genetic, Negative Genetic
MSN1 YOL116W Transcriptional activator genetic 2 1 2 Negative Genetic, Negative Genetic
SET6 YPL165C SET domain protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
GLD1 YPR109W Component of Dsc E3 ligase complex in Golgi and endosomes genetic 2 1 2 Negative Genetic, Negative Genetic
MET22 YOL064C Bisphosphate-3'-nucleotidase genetic 2 1 2 Negative Genetic, Negative Genetic
HTC1 YPL067C Putative protein of unknown function genetic 2 1 2 Positive Genetic, Positive Genetic
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 2 1 2 Negative Genetic, Negative Genetic
IRC21 YMR073C Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit regulation 1 1 1 quantitative mass spectrometry evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CAD1 YDR423C AP-1-like basic leucine zipper (bZIP) transcriptional activator regulation 1 1 1 DNA to cDNA expression microarray evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Positive Genetic
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription genetic 1 1 1 Negative Genetic
AME1 YBR211C Essential kinetochore protein associated with microtubules and SPBs genetic 1 1 1 Negative Genetic
DSN1 YIR010W Essential component of the outer kinetochore MIND complex genetic 1 1 1 Negative Genetic
LEO1 YOR123C Component of the Paf1 complex genetic 1 1 1 Positive Genetic
MTW1 YAL034W-A Essential component of the MIND kinetochore complex genetic 1 1 1 Negative Genetic
NSL1 YPL233W Essential component of the MIND kinetochore complex genetic 1 1 1 Negative Genetic
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 1 1 1 Negative Genetic
SDS22 YKL193C Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p genetic 1 1 1 Synthetic Lethality
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
EAF5 YEL018W Non-essential subunit of the NuA4 acetyltransferase complex genetic 1 1 1 Negative Genetic
DBP9 YLR276C DEAD-box protein required for 27S rRNA processing genetic 1 1 1 Negative Genetic
MAK16 YAL025C Essential nuclear protein genetic 1 1 1 Negative Genetic
NOP2 YNL061W rRNA m5C methyltransferase genetic 1 1 1 Negative Genetic
NOP7 YGR103W Component of several different pre-ribosomal particles genetic 1 1 1 Negative Genetic
RPF1 YHR088W Protein involved in assembly and export of the large ribosomal subunit genetic 1 1 1 Negative Genetic
IPI1 YHR085W Component of the Rix1 complex and possibly pre-replicative complexes genetic 1 1 1 Negative Genetic
RRP5 YMR229C RNA binding protein involved in synthesis of 18S and 5.8S rRNAs genetic 1 1 1 Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
RPC40 YPR110C RNA polymerase subunit AC40 genetic 1 1 1 Negative Genetic
RRP6 YOR001W Nuclear exosome exonuclease component physical 1 1 1 Affinity Capture-MS
RPC31 YNL151C RNA polymerase III subunit C31 genetic 1 1 1 Negative Genetic
RPA190 YOR341W RNA polymerase I largest subunit A190 genetic 1 1 1 Negative Genetic
RPA49 YNL248C RNA polymerase I subunit A49 physical 1 1 1 Affinity Capture-MS
PWP1 YLR196W Protein with WD-40 repeats involved in rRNA processing genetic 1 1 1 Negative Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 1 1 1 Affinity Capture-MS
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 1 1 1 Negative Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Negative Genetic
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 1 1 1 Negative Genetic
RPN2 YIL075C Subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
RPN3 YER021W Essential non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Negative Genetic
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
KAP95 YLR347C Karyopherin beta genetic 1 1 1 Negative Genetic
AAH1 YNL141W Adenine deaminase (adenine aminohydrolase) genetic 1 1 1 Positive Genetic
ALA1 YOR335C Cytoplasmic and mitochondrial alanyl-tRNA synthetase genetic 1 1 1 Negative Genetic
BCP1 YDR361C Essential nuclear chaperone for ribosomal protein Rpl23p genetic 1 1 1 Negative Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
PUF6 YDR496C Pumilio-homology domain protein genetic 1 1 1 Negative Genetic
ARD1 YHR013C Subunit of protein N-terminal acetyltransferase NatA genetic 1 1 1 Positive Genetic
BET3 YKR068C Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Positive Genetic
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p genetic 1 1 1 Positive Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Negative Genetic
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Positive Genetic
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 1 1 1 Negative Genetic
SDA1 YGR245C Protein required for actin organization and passage through Start genetic 1 1 1 Negative Genetic
NOG2 YNR053C Putative GTPase genetic 1 1 1 Negative Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 1 1 1 Negative Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 1 1 1 Negative Genetic
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 1 1 1 Phenotypic Suppression
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
ECM1 YAL059W Pre-ribosomal factor involved in 60S ribosomal protein subunit export physical 1 1 1 Affinity Capture-MS
ELP2 YGR200C Subunit of Elongator complex genetic 1 1 1 Positive Genetic
GCD7 YLR291C Beta subunit of translation initiation factor eIF2B physical 1 1 1 Two-hybrid
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
COG8 YML071C Component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
MCD1 YDL003W Essential alpha-kleisin subunit of the cohesin complex genetic 1 1 1 Negative Genetic
MED11 YMR112C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MED2 YDL005C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
IMG2 YCR071C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
HDA2 YDR295C Subunit of HDA1 histone deacetylase complex physical 1 1 1 Affinity Capture-MS
MPH1 YIR002C 3'-5' DNA helicase involved in error-free bypass of DNA lesions genetic 1 1 1 Negative Genetic
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos physical 1 1 1 Affinity Capture-MS
HTZ1 YOL012C Histone variant H2AZ genetic 1 1 1 Negative Genetic
AFG2 YLR397C ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex genetic 1 1 1 Negative Genetic
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 1 1 1 Negative Genetic
LAT1 YNL071W Dihydrolipoamide acetyltransferase component (E2) of the PDC genetic 1 1 1 Positive Genetic
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Lethality
RAD16 YBR114W Nucleotide excision repair (NER) protein physical 1 1 1 Affinity Capture-MS
RAD3 YER171W 5' to 3' DNA helicase genetic 1 1 1 Negative Genetic
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Negative Genetic
RAD51 YER095W Strand exchange protein genetic 1 1 1 Negative Genetic
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
NUT2 YPR168W Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
RPC11 YDR045C RNA polymerase III subunit C11 genetic 1 1 1 Negative Genetic
CTI6 YPL181W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
PUP3 YER094C Beta 3 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
SEC62 YPL094C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex genetic 1 1 1 Negative Genetic
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Positive Genetic
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Synthetic Lethality
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 1 1 1 Negative Genetic
SDC1 YDR469W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Positive Genetic
CAR2 YLR438W L-ornithine transaminase (OTAse) physical 1 1 1 Affinity Capture-MS
PYC2 YBR218C Pyruvate carboxylase isoform genetic 1 1 1 Negative Genetic
PHO85 YPL031C Cyclin-dependent kinase physical 1 1 1 Biochemical Activity
PPQ1 YPL179W Protein phosphatase that regulates the mating response genetic 1 1 1 Positive Genetic
HIR3 YJR140C Subunit of the HIR complex genetic 1 1 1 Negative Genetic
CDC53 YDL132W Cullin physical 1 1 1 Affinity Capture-MS
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway genetic 1 1 1 Negative Genetic
EGD1 YPL037C Subunit beta1 of the nascent polypeptide-associated complex (NAC) genetic 1 1 1 Negative Genetic
PDI1 YCL043C Protein disulfide isomerase genetic 1 1 1 Synthetic Lethality
PKH2 YOL100W Serine/threonine protein kinase physical 1 1 1 Reconstituted Complex
MET30 YIL046W F-box protein containing five copies of the WD40 motif physical 1 1 1 Affinity Capture-Western
PSH1 YOL054W E3 ubiquitin ligase targeting centromere-binding protein Cse4p genetic 1 1 1 Negative Genetic
PDS1 YDR113C Securin genetic 1 1 1 Negative Genetic
RPN14 YGL004C Evolutionarily conserved 19S regulatory particle assembly-chaperone genetic 1 1 1 Negative Genetic
TDP1 YBR223C Tyrosyl-DNA phosphodiesterase I physical 1 1 1 Affinity Capture-MS
SSZ1 YHR064C Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) physical 1 1 1 Affinity Capture-MS
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) physical 1 1 1 Affinity Capture-MS
YJR098C YJR098C Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
YOR342C YOR342C Protein of unknown function physical 1 1 1 Affinity Capture-MS
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit physical 1 1 1 Biochemical Activity
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-MS
YGK3 YOL128C Protein kinase related to mammalian GSK-3 glycogen synthase kinases physical 1 1 1 Reconstituted Complex
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
SRP54 YPR088C Signal recognition particle (SRP) subunit (homolog of mammalian SRP54) physical 1 1 1 Affinity Capture-MS
SRP54 YPR088C Signal recognition particle (SRP) subunit (homolog of mammalian SRP54) genetic 1 1 1 Negative Genetic
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit physical 1 1 1 Affinity Capture-MS
VTS1 YOR359W Flap-structured DNA-binding and RNA-binding protein physical 1 1 1 Affinity Capture-RNA
VMS1 YDR049W Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, physical 1 1 1 Affinity Capture-MS
UBX7 YBR273C UBX (ubiquitin regulatory X) domain-containing protein physical 1 1 1 Affinity Capture-MS
UBP2 YOR124C Ubiquitin-specific protease physical 1 1 1 Affinity Capture-MS
UBX4 YMR067C UBX domain-containing protein that interacts with Cdc48p physical 1 1 1 Affinity Capture-MS
SIS1 YNL007C Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p physical 1 1 1 Affinity Capture-MS
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes genetic 1 1 1 Negative Genetic
SSD1 YDR293C Translational repressor genetic 1 1 1 Negative Genetic
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Negative Genetic
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 1 1 1 Negative Genetic
TAF7 YMR227C TFIID subunit (67 kDa) genetic 1 1 1 Negative Genetic
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 1 1 1 Negative Genetic
UBP11 YKR098C Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
VRP1 YLR337C Verprolin, proline-rich actin-associated protein genetic 1 1 1 Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Negative Genetic
SRO9 YCL037C Cytoplasmic RNA-binding protein genetic 1 1 1 Negative Genetic
SWC3 YAL011W Protein of unknown function genetic 1 1 1 Negative Genetic
SPT2 YER161C Protein involved in negative regulation of transcription genetic 1 1 1 Negative Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 1 1 1 Positive Genetic
TEF2 YBR118W Translational elongation factor EF-1 alpha genetic 1 1 1 Negative Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 1 1 1 Negative Genetic
SNF6 YHL025W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
TPH3 YJL016W Putative protein of unknown function genetic 1 1 1 Negative Genetic
VPS13 YLL040C Lipid transport protein involved in prospore membrane morphogenesis genetic 1 1 1 Negative Genetic
SWS2 YNL081C Putative mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
TIR4 YOR009W Cell wall mannoprotein genetic 1 1 1 Negative Genetic
SSP2 YOR242C Sporulation specific protein that localizes to the spore wall genetic 1 1 1 Negative Genetic
SNU66 YOR308C Component of the U4/U6.U5 snRNP complex genetic 1 1 1 Positive Genetic
UBA3 YPR066W Protein that activates Rub1p (NEDD8) before neddylation genetic 1 1 1 Negative Genetic
YPR089W YPR089W Protein of unknown function genetic 1 1 1 Negative Genetic
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 1 1 1 Synthetic Growth Defect
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 1 1 1 Synthetic Growth Defect
VOA1 YGR106C ER protein that functions in assembly of the V0 sector of V-ATPase genetic 1 1 1 Synthetic Growth Defect
VPS72 YDR485C Htz1p-binding component of the SWR1 complex genetic 1 1 1 Synthetic Rescue
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 1 1 1 Dosage Rescue
SSM4 YIL030C Membrane-embedded ubiquitin-protein ligase and retrotranslocase genetic 1 1 1 Negative Genetic
VPS60 YDR486C Protein involved in late endosome to vacuole transport genetic 1 1 1 Negative Genetic
YAP1801 YHR161C Protein of the AP180 family, involved in clathrin cage assembly genetic 1 1 1 Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Positive Genetic
TPM2 YIL138C Minor isoform of tropomyosin genetic 1 1 1 Negative Genetic
YPT35 YHR105W Endosomal protein of unknown function genetic 1 1 1 Negative Genetic
STH1 YIL126W ATPase component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
SSH1 YBR283C Subunit of the Ssh1 translocon complex genetic 1 1 1 Positive Genetic
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 1 1 1 Positive Genetic
SPC19 YDR201W Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
SMC1 YFL008W Subunit of the multiprotein cohesin complex genetic 1 1 1 Negative Genetic
SPC105 YGL093W Subunit of a kinetochore-microtubule binding complex genetic 1 1 1 Negative Genetic
STS1 YIR011C Protein required for localizing proteasomes to the nucleus genetic 1 1 1 Negative Genetic
SMC3 YJL074C Subunit of the multiprotein cohesin complex genetic 1 1 1 Negative Genetic
SSC1 YJR045C Hsp70 family ATPase genetic 1 1 1 Negative Genetic
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 1 1 1 Negative Genetic
YHC1 YLR298C Component of the U1 snRNP complex required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
SPC24 YMR117C Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Negative Genetic
SRV2 YNL138W CAP (cyclase-associated protein) genetic 1 1 1 Negative Genetic
TIF6 YPR016C Constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
SNF1 YDR477W AMP-activated S/T protein kinase genetic 1 1 1 Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Negative Genetic
SYF2 YGR129W Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 1 1 1 Negative Genetic
YJR084W YJR084W Protein that forms a complex with Thp3p genetic 1 1 1 Negative Genetic
YPT7 YML001W Rab family GTPase genetic 1 1 1 Negative Genetic
TAT2 YOL020W High affinity tryptophan and tyrosine permease genetic 1 1 1 Negative Genetic
VPS68 YOL129W Vacuolar membrane protein of unknown function genetic 1 1 1 Negative Genetic
YOR062C YOR062C Protein of unknown function genetic 1 1 1 Negative Genetic
YPR196W YPR196W Putative maltose-responsive transcription factor genetic 1 1 1 Negative Genetic
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase physical 1 1 1 Affinity Capture-MS
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 1 1 1 Negative Genetic
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation physical 1 1 1 Affinity Capture-MS
RVS167 YDR388W Calmodulin-binding actin-associated protein physical 1 1 1 Affinity Capture-MS
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 1 1 1 Negative Genetic
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 1 1 1 Negative Genetic
CIN8 YEL061C Bipolar kinesin motor protein genetic 1 1 1 Synthetic Lethality
ARE1 YCR048W Acyl-CoA:sterol acyltransferase genetic 1 1 1 Negative Genetic
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation genetic 1 1 1 Negative Genetic
FAA1 YOR317W Long chain fatty acyl-CoA synthetase genetic 1 1 1 Negative Genetic
SGT1 YOR057W Cochaperone protein genetic 1 1 1 Negative Genetic
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 1 1 1 Positive Genetic
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) genetic 1 1 1 Negative Genetic
KIN28 YDL108W Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly physical 1 1 1 Reconstituted Complex
CIK1 YMR198W Kinesin-associated protein genetic 1 1 1 Negative Genetic
AHC1 YOR023C Subunit of the Ada histone acetyltransferase complex genetic 1 1 1 Negative Genetic
HMG2 YLR450W HMG-CoA reductase physical 1 1 1 Affinity Capture-MS
FKH2 YNL068C Forkhead family transcription factor genetic 1 1 1 Positive Genetic
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 1 1 1 Negative Genetic
GBP2 YCL011C Poly(A+) RNA-binding protein genetic 1 1 1 Negative Genetic
DAD1 YDR016C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
ARP1 YHR129C Actin-related protein of the dynactin complex genetic 1 1 1 Negative Genetic
ADE2 YOR128C Phosphoribosylaminoimidazole carboxylase genetic 1 1 1 Positive Genetic
ATG1 YGL180W Protein serine/threonine kinase genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
NDC80 YIL144W Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Negative Genetic
NUF2 YOL069W Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Negative Genetic
CSM3 YMR048W Replication fork associated factor genetic 1 1 1 Synthetic Growth Defect
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Negative Genetic
SAE2 YGL175C Endonuclease required for telomere elongation genetic 1 1 1 Negative Genetic
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Negative Genetic
RUB1 YDR139C Ubiquitin-like protein with similarity to mammalian NEDD8 genetic 1 1 1 Negative Genetic
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 1 1 1 Negative Genetic
COG4 YPR105C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Synthetic Rescue
APC11 YDL008W Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
NNF1 YJR112W Essential component of the outer kinetochore MIND complex genetic 1 1 1 Negative Genetic
CHL1 YPL008W Probable DNA helicase genetic 1 1 1 Negative Genetic
RPL9A YGL147C Ribosomal 60S subunit protein L9A genetic 1 1 1 Positive Genetic
RPL9B YNL067W Ribosomal 60S subunit protein L9B genetic 1 1 1 Negative Genetic
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Positive Genetic
SFL1 YOR140W Transcriptional repressor and activator physical 1 1 1 Affinity Capture-MS
MIF2 YKL089W Centromeric CDEIII region binding protein genetic 1 1 1 Positive Genetic
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
CTK2 YJL006C Beta subunit of C-terminal domain kinase I (CTDK-I) physical 1 1 1 Reconstituted Complex
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family genetic 1 1 1 Synthetic Growth Defect
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 1 1 1 Negative Genetic
RPA14 YDR156W RNA polymerase I subunit A14 genetic 1 1 1 Negative Genetic
SED5 YLR026C cis-Golgi t-SNARE syntaxin genetic 1 1 1 Positive Genetic
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Positive Genetic
PAM18 YLR008C Subunit of the import motor (PAM complex) genetic 1 1 1 Negative Genetic
HSF1 YGL073W Trimeric heat shock transcription factor genetic 1 1 1 Negative Genetic
RRN7 YJL025W Component of the core factor (CF) rDNA transcription factor complex genetic 1 1 1 Negative Genetic
CCS1 YMR038C Copper chaperone for superoxide dismutase Sod1p genetic 1 1 1 Negative Genetic
FBP1 YLR377C Fructose-1,6-bisphosphatase physical 1 1 1 Affinity Capture-MS
HMT1 YBR034C Nuclear SAM-dependent mono- and asymmetric methyltransferase physical 1 1 1 Affinity Capture-MS
PEX11 YOL147C Peroxisomal protein required for medium-chain fatty acid oxidation genetic 1 1 1 Negative Genetic
MSB4 YOL112W GTPase-activating protein of the Ras superfamily genetic 1 1 1 Positive Genetic
CHS5 YLR330W Component of the exomer complex genetic 1 1 1 Negative Genetic
PRI1 YIR008C Subunit of DNA primase genetic 1 1 1 Positive Genetic
RDI1 YDL135C Rho GDP dissociation inhibitor genetic 1 1 1 Negative Genetic
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
DID2 YKR035W-A Class E protein of the vacuolar protein-sorting (Vps) pathway genetic 1 1 1 Negative Genetic
KAP120 YPL125W Karyopherin responsible for the nuclear import of Rpf1p genetic 1 1 1 Negative Genetic
CIN2 YPL241C GTPase-activating protein (GAP) for Cin4p genetic 1 1 1 Negative Genetic
ERV14 YGL054C COPII-coated vesicle protein genetic 1 1 1 Negative Genetic
ATM1 YMR301C Mitochondrial inner membrane ATP-binding cassette (ABC) transporter physical 1 1 1 Affinity Capture-MS
RRS1 YOR294W Essential protein that binds ribosomal protein L11 genetic 1 1 1 Negative Genetic
RPS0A YGR214W Ribosomal 40S subunit protein S0A genetic 1 1 1 Negative Genetic
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 1 1 1 Negative Genetic
PDS5 YMR076C Cohesion maintenance factor genetic 1 1 1 Negative Genetic
SAC7 YDR389W GTPase activating protein (GAP) for Rho1p genetic 1 1 1 Negative Genetic
PAC1 YOR269W Regulator of dynein, involved in intracellular transport genetic 1 1 1 Negative Genetic
OKP1 YGR179C Outer kinetochore protein required for accurate chromosome segregation genetic 1 1 1 Negative Genetic
GLR1 YPL091W Cytosolic and mitochondrial glutathione oxidoreductase genetic 1 1 1 Negative Genetic
HCM1 YCR065W Forkhead transcription factor genetic 1 1 1 Negative Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 1 1 1 Positive Genetic
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Negative Genetic
ORC6 YHR118C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
PDR11 YIL013C ATP-binding cassette (ABC) transporter genetic 1 1 1 Negative Genetic
JHD2 YJR119C JmjC domain family histone demethylase genetic 1 1 1 Negative Genetic
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Positive Genetic
NTO1 YPR031W Subunit of the NuA3 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
BPH1 YCR032W Protein homologous to Chediak-Higashi syndrome and Beige proteins genetic 1 1 1 Negative Genetic
AIM22 YJL046W Lipoate-protein ligase genetic 1 1 1 Negative Genetic
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
IRC3 YDR332W Double-stranded DNA-dependent helicase of the DExH/D-box family genetic 1 1 1 Synthetic Growth Defect
ORC4 YPR162C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
ALD6 YPL061W Cytosolic aldehyde dehydrogenase genetic 1 1 1 Positive Genetic
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 1 1 1 Negative Genetic
IZH3 YLR023C Membrane protein involved in zinc ion homeostasis genetic 1 1 1 Negative Genetic
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 1 1 1 Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
RNH201 YNL072W Ribonuclease H2 catalytic subunit genetic 1 1 1 Negative Genetic
COA4 YLR218C Twin Cx(9)C protein involved in cytochrome c oxidase organization genetic 1 1 1 Negative Genetic
CUZ1 YNL155W Protein with a role in the ubiquitin-proteasome pathway genetic 1 1 1 Synthetic Growth Defect
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-RNA
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 1 1 1 Negative Genetic
LAG2 YOL025W Protein that negatively regulates the SCF E3-ubiquitin ligase genetic 1 1 1 Negative Genetic
RDS2 YPL133C Transcription factor involved in regulating gluconeogenesis physical 1 1 1 Affinity Capture-MS
ALT1 YLR089C Alanine transaminase (glutamic pyruvic transaminase) genetic 1 1 1 Positive Genetic
SDD2 YMR074C Protein with homology to human PDCD5 genetic 1 1 1 Negative Genetic
RPS0B YLR048W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
DFM1 YDR411C Endoplasmic reticulum (ER) localized protein physical 1 1 1 Affinity Capture-Western
PTK2 YJR059W Serine/threonine protein kinase physical 1 1 1 Biochemical Activity
LAG1 YHL003C Ceramide synthase component genetic 1 1 1 Negative Genetic
RNY1 YPL123C Vacuolar RNase of the T(2) family genetic 1 1 1 Negative Genetic
PKH3 YDR466W Protein kinase with similarity to mammalian PDK1 and yeast Pkh1p/Phk2p physical 1 1 1 Reconstituted Complex
MDM34 YGL219C Mitochondrial component of the ERMES complex genetic 1 1 1 Positive Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Negative Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Positive Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Negative Genetic
MLO127 YJR039W Mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
ISC1 YER019W Inositol phosphosphingolipid phospholipase C genetic 1 1 1 Negative Genetic
PFD1 YJL179W Subunit of heterohexameric prefoldin genetic 1 1 1 Negative Genetic
CYT2 YKL087C Cytochrome c1 heme lyase genetic 1 1 1 Positive Genetic
LDS2 YOL047C Protein Involved in spore wall assembly genetic 1 1 1 Negative Genetic
IRC15 YPL017C Microtubule associated protein genetic 1 1 1 Negative Genetic
RPL21B YPL079W Ribosomal 60S subunit protein L21B genetic 1 1 1 Positive Genetic
DAL4 YIR028W Allantoin permease genetic 1 1 1 Negative Genetic
MFM1 YPL060W Mitochondrial inner membrane magnesium transporter genetic 1 1 1 Negative Genetic
RIB2 YOL066C Bifunctional DRAP deaminase tRNA:pseudouridine synthase genetic 1 1 1 Negative Genetic
RTC6 YPL183W-A Protein involved in translation genetic 1 1 1 Positive Genetic
KCH1 YJR054W Potassium transporter that mediates K+ influx genetic 1 1 1 Negative Genetic