Standard name Systematic name Name description Description
LAG1 YHL003C Ceramide synthase component Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress; homolog of human CERS2, a tumor metastasis suppressor gene whose silencing enhances invasion/metastasis of prostate cancer cells; LAG1 has a paralog, LAC1, that arose from the whole genome duplication
Visualize the interactome of LAG1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
S 61

CYCLoPs localization & abundance

WT1 WT2 WT3
ER 0.703 0.722 0.226
Nuc Periphery 0.531 0.211 0.249
Vac/Vac Memb 0.156 0.211 0.467
Golgi NaN NaN 0.103

GFP localization & abundance

GFP localization GFP abundance
ER technical problem

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
LAG1 2 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0263 (ceramide-1 synthase (24C)), r_0264 (ceramide-1 synthase (26C)), r_0265 (ceramide-2 synthase (24C)), r_0266 (ceramide-2 synthase (26C))

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
LAC1 YKL008C Ceramide synthase component genetic 15 4 13 Synthetic Growth Defect, Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
ELO3 YLR372W Elongase genetic 5 1 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
LAC1 YKL008C Ceramide synthase component physical 5 3 4 Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, PCA, PCA
YPC1 YBR183W Alkaline ceramidase genetic 4 3 3 Dosage Rescue, Phenotypic Enhancement, Dosage Rescue, Synthetic Lethality
YDC1 YPL087W Alkaline dihydroceramidase, involved in sphingolipid metabolism genetic 4 3 3 Dosage Rescue, Phenotypic Enhancement, Dosage Rescue, Synthetic Lethality
LIP1 YMR298W Ceramide synthase subunit physical 4 2 3 Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 4 1 3 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 4 1 3 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
GET1 YGL020C Subunit of the GET complex genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 2 1 2 Negative Genetic, Negative Genetic
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 2 1 1 Positive Genetic, Positive Genetic
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 2 1 1 Negative Genetic, Negative Genetic
ROT1 YMR200W Molecular chaperone involved in protein folding in ER genetic 2 1 1 Negative Genetic, Negative Genetic
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 2 1 1 Positive Genetic, Positive Genetic
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 2 1 1 Positive Genetic, Positive Genetic
RGP1 YDR137W Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) genetic 2 1 1 Positive Genetic, Positive Genetic
GUP1 YGL084C Plasma membrane protein involved in remodeling GPI anchors genetic 2 1 1 Positive Genetic, Positive Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein regulation 1 1 1 beta-galactosidase reporter gene assay evidence
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci regulation 1 1 1 DNA to cDNA expression microarray evidence
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CKA2 YOR061W Alpha' catalytic subunit of casein kinase 2 (CK2) genetic 1 1 1 Dosage Growth Defect
BCP1 YDR361C Essential nuclear chaperone for ribosomal protein Rpl23p genetic 1 1 1 Negative Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CEG1 YGL130W Guanylyltransferase involved in mRNA 5' capping genetic 1 1 1 Negative Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
IPP1 YBR011C Cytoplasmic inorganic pyrophosphatase (PPase) genetic 1 1 1 Negative Genetic
KRR1 YCL059C Nucleolar protein required for rRNA synthesis and ribosomal assembly genetic 1 1 1 Positive Genetic
AVT4 YNL101W Vacuolar transporter physical 1 1 1 PCA
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Positive Genetic
DPB11 YJL090C DNA replication initiation protein genetic 1 1 1 Negative Genetic
GAL2 YLR081W Galactose permease genetic 1 1 1 Negative Genetic
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 1 1 1 Synthetic Growth Defect
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
CSG2 YBR036C Endoplasmic reticulum membrane protein physical 1 1 1 PCA
ERG25 YGR060W C-4 methyl sterol oxidase physical 1 1 1 PCA
ERG2 YMR202W C-8 sterol isomerase genetic 1 1 1 Positive Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
ECM3 YOR092W Non-essential protein of unknown function physical 1 1 1 PCA
ERP5 YHR110W Protein with similarity to Emp24p and Erv25p physical 1 1 1 PCA
RCK1 YGL158W Protein kinase involved in oxidative stress response physical 1 1 1 Biochemical Activity
YPL150W YPL150W Protein kinase of unknown cellular role physical 1 1 1 Biochemical Activity
SEC62 YPL094C Essential subunit of Sec63 complex physical 1 1 1 Two-hybrid
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex physical 1 1 1 Two-hybrid
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
WBP1 YEL002C Beta subunit of the oligosaccharyl transferase glycoprotein complex physical 1 1 1 PCA
SPC1 YJR010C-A Subunit of the signal peptidase complex (SPC) physical 1 1 1 PCA
SWP1 YMR149W Delta subunit of the oligosaccharyl transferase glycoprotein complex physical 1 1 1 PCA
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
YPK1 YKL126W S/T protein kinase physical 1 1 1 Biochemical Activity
YPK1 YKL126W S/T protein kinase genetic 1 1 1 Dosage Growth Defect
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 1 1 1 Synthetic Growth Defect
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component genetic 1 1 1 Negative Genetic
SLC1 YDL052C 1-acyl-sn-glycerol-3-phosphate acyltransferase genetic 1 1 1 Synthetic Rescue
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
NCR1 YPL006W Vacuolar membrane protein involved with Npc2p in sterol trafficking genetic 1 1 1 Negative Genetic
LCB3 YJL134W Long-chain base-1-phosphate phosphatase genetic 1 1 1 Negative Genetic
VBA1 YMR088C Permease of basic amino acids in the vacuolar membrane genetic 1 1 1 Positive Genetic
UIP3 YAR027W Putative integral membrane protein of unknown function genetic 1 1 1 Negative Genetic
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 1 1 1 Negative Genetic
SEC18 YBR080C AAA ATPase and SNARE disassembly chaperone genetic 1 1 1 Positive Genetic
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Dosage Growth Defect
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 1 1 1 Positive Genetic
MAK5 YBR142W Essential nucleolar protein genetic 1 1 1 Negative Genetic
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
SMC1 YFL008W Subunit of the multiprotein cohesin complex genetic 1 1 1 Negative Genetic
STS1 YIR011C Protein required for localizing proteasomes to the nucleus genetic 1 1 1 Negative Genetic
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 1 1 1 Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Negative Genetic
TAD3 YLR316C Subunit of tRNA-specific adenosine-34 deaminase genetic 1 1 1 Negative Genetic
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 1 1 1 Negative Genetic
MKT1 YNL085W Protein similar to nucleases that forms a complex with Pbp1p genetic 1 1 1 Negative Genetic
YAR029W YAR029W Member of DUP240 gene family but contains no transmembrane domains genetic 1 1 1 Negative Genetic
PEP1 YBL017C Type I transmembrane sorting receptor for multiple vacuolar hydrolases genetic 1 1 1 Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
PEX19 YDL065C Chaperone and import receptor for newly-synthesized class I PMPs genetic 1 1 1 Negative Genetic
MRK1 YDL079C Glycogen synthase kinase 3 (GSK-3) homolog genetic 1 1 1 Negative Genetic
VAM7 YGL212W Vacuolar SNARE protein genetic 1 1 1 Negative Genetic
YJR011C YJR011C Putative protein of unknown function genetic 1 1 1 Negative Genetic
PEX13 YLR191W Peroxisomal importomer complex component genetic 1 1 1 Negative Genetic
RPL6B YLR448W Ribosomal 60S subunit protein L6B genetic 1 1 1 Negative Genetic
RCF2 YNR018W Cytochrome c oxidase subunit genetic 1 1 1 Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
YVC1 YOR087W Vacuolar cation channel genetic 1 1 1 Negative Genetic
PTP2 YOR208W Phosphotyrosine-specific phosphatase genetic 1 1 1 Negative Genetic
POC4 YPL144W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 1 1 1 Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Negative Genetic
CHS7 YHR142W Protein of unknown function physical 1 1 1 PCA
COS8 YHL048W Endosomal protein involved in turnover of plasma membrane proteins physical 1 1 1 PCA
DSC3 YOR223W Subunit of the DSC ubiquitin ligase complex physical 1 1 1 Two-hybrid
HMX1 YLR205C ER localized heme oxygenase genetic 1 1 1 Negative Genetic
AGP1 YCL025C Broad-specificity, low-affinity amino acid permease physical 1 1 1 PCA
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex physical 1 1 1 PCA
CSS3 YOL159C Protein of unknown function, secreted when constitutively expressed genetic 1 1 1 Negative Genetic