Standard name Systematic name Name description Description
COS8 YHL048W Endosomal protein involved in turnover of plasma membrane proteins Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins
Visualize the interactome of COS8
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1/S 47

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.837 NaN NaN
ER 0.074 NaN NaN
Mito 0.104 NaN NaN

GFP localization & abundance

GFP localization GFP abundance
ambiguous 3070

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
COS8 1 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
FKH1 YIL131C Forkhead family transcription factor regulation 3 3 3 chromatin immunoprecipitation- exonuclease evidence, chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
SEC63 YOR254C Essential subunit of Sec63 complex physical 2 2 2 PCA, Two-hybrid
ZAP1 YJL056C Zinc-regulated transcription factor regulation 2 1 2 DNA to cDNA expression microarray evidence, DNA to cDNA expression microarray evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) regulation 1 1 1 DNA to cDNA expression microarray evidence
UME6 YDR207C Rpd3L histone deacetylase complex subunit regulation 1 1 1 DNA to cDNA expression microarray evidence
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family regulation 1 1 1 RNA-sequencing evidence
SIR3 YLR442C Silencing protein regulation 1 1 1 RNA-sequencing evidence
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains regulation 1 1 1 RNA-sequencing evidence
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes regulation 1 1 1 DNA to cDNA expression microarray evidence
UGA3 YDL170W Transcriptional activator for GABA-dependent induction of GABA genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ARC35 YNR035C Subunit of the ARP2/3 complex genetic 1 1 1 Negative Genetic
BUD14 YAR014C Protein involved in bud-site selection physical 1 1 1 Two-hybrid
AMF1 YOR378W Low affinity NH4+ transporter physical 1 1 1 PCA
ARE2 YNR019W Acyl-CoA:sterol acyltransferase physical 1 1 1 PCA
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
AUR1 YKL004W Phosphatidylinositol:ceramide phosphoinositol transferase physical 1 1 1 PCA
ALG1 YBR110W Mannosyltransferase physical 1 1 1 PCA
CHS7 YHR142W Protein of unknown function physical 1 1 1 PCA
ERG11 YHR007C Lanosterol 14-alpha-demethylase physical 1 1 1 PCA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
YAR023C YAR023C Putative integral membrane protein physical 1 1 1 PCA
MST28 YAR033W Putative integral membrane protein, involved in vesicle formation physical 1 1 1 PCA
MST27 YGL051W Putative integral membrane protein, involved in vesicle formation physical 1 1 1 PCA
YPC1 YBR183W Alkaline ceramidase physical 1 1 1 PCA
SND3 YBR106W Involved in SRP-independent protein targeting to the ER physical 1 1 1 PCA
IFA38 YBR159W Microsomal beta-keto-reductase physical 1 1 1 PCA
ELO2 YCR034W Fatty acid elongase, involved in sphingolipid biosynthesis physical 1 1 1 PCA
ELO2 YCR034W Fatty acid elongase, involved in sphingolipid biosynthesis genetic 1 1 1 Synthetic Rescue
TVS1 YCR061W Protein of unknown function physical 1 1 1 PCA
TVS1 YCR061W Protein of unknown function genetic 1 1 1 Synthetic Rescue
TSC13 YDL015C Enoyl reductase physical 1 1 1 PCA
SHR3 YDL212W Endoplasmic reticulum packaging chaperone physical 1 1 1 PCA
SHO1 YER118C Transmembrane osmosensor for filamentous growth and HOG pathways physical 1 1 1 PCA
RSM23 YGL129C Mitochondrial ribosomal protein of the small subunit physical 1 1 1 PCA
ERV29 YGR284C Protein localized to COPII-coated vesicles physical 1 1 1 PCA
MAL11 YGR289C High-affinity maltose transporter (alpha-glucoside transporter) physical 1 1 1 PCA
LAG1 YHL003C Ceramide synthase component physical 1 1 1 PCA
VMA16 YHR026W Subunit c'' of the vacuolar ATPase physical 1 1 1 PCA
YHR140W YHR140W Endoplasmic reticulum protein physical 1 1 1 PCA
SNL1 YIL016W Ribosome-associated protein physical 1 1 1 PCA
OST1 YJL002C Alpha subunit of the oligosaccharyltransferase complex of the ER lumen physical 1 1 1 PCA
GWT1 YJL091C Protein involved in the inositol acylation of GlcN-PI physical 1 1 1 PCA
PRM10 YJL108C Pheromone-regulated protein physical 1 1 1 PCA
PHO86 YJL117W Endoplasmic reticulum (ER) resident protein physical 1 1 1 PCA
ELO1 YJL196C Elongase I, medium-chain acyl elongase physical 1 1 1 PCA
STE24 YJR117W Highly conserved zinc metalloprotease physical 1 1 1 PCA
LAC1 YKL008C Ceramide synthase component physical 1 1 1 PCA
YET1 YKL065C Endoplasmic reticulum transmembrane protein physical 1 1 1 PCA
SRP102 YKL154W Signal recognition particle (SRP) receptor beta subunit physical 1 1 1 PCA
ELO3 YLR372W Elongase physical 1 1 1 PCA
ELO3 YLR372W Elongase genetic 1 1 1 Synthetic Rescue
GSF2 YML048W Endoplasmic reticulum (ER) localized integral membrane protein physical 1 1 1 PCA
FMP42 YMR221C Putative protein of unknown function physical 1 1 1 PCA
CUE1 YMR264W Ubiquitin-binding protein physical 1 1 1 PCA
PFA4 YOL003C Palmitoyltransferase with autoacylation activity physical 1 1 1 PCA
ERP4 YOR016C Member of the p24 family involved in ER to Golgi transport physical 1 1 1 PCA
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI physical 1 1 1 PCA
SSU1 YPL092W Plasma membrane sulfite pump involved in sulfite metabolism physical 1 1 1 PCA
YOP1 YPR028W Reticulon-interacting protein physical 1 1 1 PCA
TPO3 YPR156C Polyamine transporter of the major facilitator superfamily physical 1 1 1 PCA
TVP38 YKR088C Integral membrane protein physical 1 1 1 PCA
CPT1 YNL130C Cholinephosphotransferase physical 1 1 1 PCA
SLF1 YDR515W RNA binding protein that associates with polysomes physical 1 1 1 Affinity Capture-RNA
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
NFT1 YKR103W Putative transporter of the MRP subfamily physical 1 1 1 PCA
YKR104W YKR104W Putative transporter of the MRP subfamily physical 1 1 1 PCA
PDR12 YPL058C Plasma membrane ATP-binding cassette (ABC) transporter physical 1 1 1 PCA
IRE1 YHR079C Serine-threonine kinase and endoribonuclease genetic 1 1 1 Synthetic Rescue
ERG25 YGR060W C-4 methyl sterol oxidase genetic 1 1 1 Negative Genetic
NOP56 YLR197W Essential evolutionarily-conserved nucleolar protein genetic 1 1 1 Positive Genetic
MCD1 YDL003W Essential alpha-kleisin subunit of the cohesin complex genetic 1 1 1 Negative Genetic
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer genetic 1 1 1 Negative Genetic
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Negative Genetic
ORC6 YHR118C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
PRP19 YLL036C Splicing factor associated with the spliceosome genetic 1 1 1 Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Negative Genetic
MED4 YOR174W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
AQY1 YPR192W Spore-specific water channel physical 1 1 1 PCA