Standard name Systematic name Name description Description
ORC4 YPR162C Subunit of the origin recognition complex (ORC) Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; ORC4 has a paralog, RIF2, that arose from the whole genome duplication
Visualize the interactome of ORC4
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data 2170

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
ORC4 0 0 0 0 2

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
ORC1 YML065W Largest subunit of the origin recognition complex physical 18 6 14 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Two-hybrid, Reconstituted Complex, Co-purification, Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Two-hybrid, Co-fractionation, Co-purification, Reconstituted Complex
ORC5 YNL261W Subunit of the origin recognition complex (ORC) physical 13 4 8 Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Two-hybrid, Reconstituted Complex, Two-hybrid, Two-hybrid, Reconstituted Complex
ORC2 YBR060C Subunit of the origin recognition complex (ORC) physical 7 3 6 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex
ORC3 YLL004W Subunit of the origin recognition complex (ORC) physical 5 3 4 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid
ORC6 YHR118C Subunit of the origin recognition complex (ORC) physical 4 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
CDC6 YJL194W Essential ATP-binding protein required for DNA replication physical 3 1 3 Reconstituted Complex, Reconstituted Complex, Reconstituted Complex
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HAT1 YPL001W Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex physical 3 1 2 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
DDC1 YPL194W DNA damage checkpoint protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
OKP1 YGR179C Outer kinetochore protein required for accurate chromosome segregation genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RFC5 YBR087W Subunit of heteropentameric Replication factor C (RF-C) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RAD17 YOR368W Checkpoint protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ORC5 YNL261W Subunit of the origin recognition complex (ORC) genetic 2 2 2 Dosage Rescue, Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 2 1 2 Negative Genetic, Negative Genetic
HAT2 YEL056W Subunit of the Hat1p-Hat2p histone acetyltransferase complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
HIR3 YJR140C Subunit of the HIR complex genetic 2 1 2 Negative Genetic, Negative Genetic
HIR2 YOR038C Subunit of HIR nucleosome assembly complex genetic 2 1 2 Negative Genetic, Negative Genetic
MEC3 YLR288C DNA damage and meiotic pachytene checkpoint protein genetic 2 1 2 Negative Genetic, Negative Genetic
NDC80 YIL144W Component of the kinetochore-associated Ndc80 complex genetic 2 1 2 Negative Genetic, Negative Genetic
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 2 1 2 Negative Genetic, Negative Genetic
STI1 YOR027W Evolutionarily-conserved Hsp90 cochaperone genetic 2 1 2 Negative Genetic, Negative Genetic
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex genetic 2 1 2 Negative Genetic, Negative Genetic
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 2 1 2 Negative Genetic, Negative Genetic
SMA2 YML066C Meiosis-specific prospore membrane protein genetic 2 1 2 Negative Genetic, Negative Genetic
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 2 1 2 Negative Genetic, Negative Genetic
SLK19 YOR195W Kinetochore-associated protein genetic 2 1 2 Negative Genetic, Negative Genetic
LDB18 YLL049W Component of the dynactin complex genetic 2 1 2 Negative Genetic, Negative Genetic
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 2 2 1 PCA, Affinity Capture-MS
CFT2 YLR115W Subunit of the mRNA cleavage and polyadenlylation factor (CPF) genetic 2 1 1 Negative Genetic, Negative Genetic
CDC14 YFR028C Protein phosphatase required for mitotic exit genetic 2 1 1 Negative Genetic, Negative Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 2 1 1 Negative Genetic, Negative Genetic
CDC16 YKL022C Subunit of the anaphase-promoting complex/cyclosome (APC/C) genetic 2 1 1 Negative Genetic, Negative Genetic
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex genetic 2 1 1 Negative Genetic, Negative Genetic
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 2 1 1 Negative Genetic, Negative Genetic
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 2 1 1 Negative Genetic, Negative Genetic
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 2 1 1 Negative Genetic, Negative Genetic
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 2 1 1 Negative Genetic, Negative Genetic
DPB11 YJL090C DNA replication initiation protein genetic 2 1 1 Negative Genetic, Negative Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 2 1 1 Negative Genetic, Negative Genetic
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 2 1 1 Negative Genetic, Negative Genetic
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 2 1 1 Negative Genetic, Negative Genetic
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 2 1 1 Negative Genetic, Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 2 1 1 Negative Genetic, Negative Genetic
CSM3 YMR048W Replication fork associated factor genetic 2 1 1 Negative Genetic, Negative Genetic
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 2 1 1 Negative Genetic, Negative Genetic
CDC27 YBL084C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 2 1 1 Negative Genetic, Negative Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 2 1 1 Negative Genetic, Negative Genetic
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 2 1 1 Negative Genetic, Negative Genetic
ORC3 YLL004W Subunit of the origin recognition complex (ORC) genetic 2 1 1 Negative Genetic, Negative Genetic
HSF1 YGL073W Trimeric heat shock transcription factor genetic 2 1 1 Negative Genetic, Negative Genetic
MCM7 YBR202W Component of the Mcm2-7 hexameric helicase complex genetic 2 1 1 Negative Genetic, Negative Genetic
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 2 1 1 Negative Genetic, Negative Genetic
ORC6 YHR118C Subunit of the origin recognition complex (ORC) genetic 2 1 1 Negative Genetic, Negative Genetic
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
TAH11 YJR046W DNA replication licensing factor genetic 2 1 1 Negative Genetic, Negative Genetic
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 2 1 1 Negative Genetic, Negative Genetic
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 2 1 1 Negative Genetic, Negative Genetic
PDS1 YDR113C Securin genetic 2 1 1 Negative Genetic, Negative Genetic
RNA15 YGL044C Component of the cleavage and polyadenylation factor I (CF I) genetic 2 1 1 Negative Genetic, Negative Genetic
SLD3 YGL113W Protein involved in the initiation of DNA replication genetic 2 1 1 Negative Genetic, Negative Genetic
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 2 1 1 Negative Genetic, Negative Genetic
PRI2 YKL045W Subunit of DNA primase genetic 2 1 1 Negative Genetic, Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 2 1 1 Negative Genetic, Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 2 1 1 Negative Genetic, Negative Genetic
PTC6 YCR079W Mitochondrial type 2C protein phosphatase (PP2C) genetic 2 1 1 Negative Genetic, Negative Genetic
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 2 1 1 Negative Genetic, Negative Genetic
SAS4 YDR181C Subunit of the SAS complex (Sas2p, Sas4p, Sas5p) genetic 2 1 1 Negative Genetic, Negative Genetic
SPT2 YER161C Protein involved in negative regulation of transcription genetic 2 1 1 Negative Genetic, Negative Genetic
RAD24 YER173W Checkpoint protein genetic 2 1 1 Negative Genetic, Negative Genetic
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 2 1 1 Negative Genetic, Negative Genetic
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 2 1 1 Negative Genetic, Negative Genetic
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 2 1 1 Negative Genetic, Negative Genetic
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 2 1 1 Negative Genetic, Negative Genetic
RFM1 YOR279C Component of the Sum1p-Rfm1p-Hst1p complex genetic 2 1 1 Negative Genetic, Negative Genetic
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit regulation 1 1 1 quantitative mass spectrometry evidence
NSL1 YPL233W Essential component of the MIND kinetochore complex genetic 1 1 1 Negative Genetic
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 1 1 1 Negative Genetic
NAF1 YNL124W RNA-binding protein required for the assembly of box H/ACA snoRNPs genetic 1 1 1 Negative Genetic
NOP56 YLR197W Essential evolutionarily-conserved nucleolar protein genetic 1 1 1 Negative Genetic
DBP7 YKR024C Putative ATP-dependent RNA helicase of the DEAD-box family genetic 1 1 1 Negative Genetic
CSL4 YNL232W Exosome non-catalytic core component genetic 1 1 1 Positive Genetic
GCD11 YER025W Gamma subunit of the translation initiation factor eIF2 genetic 1 1 1 Negative Genetic
MED7 YOL135C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein genetic 1 1 1 Negative Genetic
HGH1 YGR187C Chaperone protein for translation factor eEF2 genetic 1 1 1 Negative Genetic
ACC1 YNR016C Acetyl-CoA carboxylase, biotin containing enzyme genetic 1 1 1 Negative Genetic
APC1 YNL172W Largest subunit of the Anaphase-Promoting Complex/Cyclosome genetic 1 1 1 Negative Genetic
APC2 YLR127C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
ASF1 YJL115W Nucleosome assembly factor genetic 1 1 1 Negative Genetic
BUD20 YLR074C C2H2-type zinc finger protein required for ribosome assembly genetic 1 1 1 Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Negative Genetic
CDC10 YCR002C Component of the septin ring, required for cytokinesis genetic 1 1 1 Negative Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Positive Genetic
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CDC45 YLR103C DNA replication initiation factor genetic 1 1 1 Negative Genetic
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 1 1 1 Negative Genetic
DPB2 YPR175W Second largest subunit of DNA polymerase II (DNA polymerase epsilon) physical 1 1 1 Affinity Capture-MS
DPB3 YBR278W Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) genetic 1 1 1 Negative Genetic
FIP1 YJR093C Subunit of cleavage polyadenylation factor (CPF) genetic 1 1 1 Negative Genetic
HHF1 YBR009C Histone H4 physical 1 1 1 Affinity Capture-MS
AEP1 YMR064W Protein required for expression of the mitochondrial OLI1 gene genetic 1 1 1 Negative Genetic
HHF2 YNL030W Histone H4 physical 1 1 1 Affinity Capture-MS
HST1 YOL068C NAD(+)-dependent histone deacetylase genetic 1 1 1 Negative Genetic
HTB2 YBL002W Histone H2B physical 1 1 1 Affinity Capture-MS
LAS17 YOR181W Actin assembly factor genetic 1 1 1 Positive Genetic
LCB1 YMR296C Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
MCD1 YDL003W Essential alpha-kleisin subunit of the cohesin complex genetic 1 1 1 Negative Genetic
MCM6 YGL201C Protein involved in DNA replication genetic 1 1 1 Negative Genetic
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 1 1 1 Negative Genetic
MRPL1 YDR116C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MRPL25 YGR076C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MSH2 YOL090W Protein that binds to DNA mismatches genetic 1 1 1 Negative Genetic
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 1 1 1 Negative Genetic
MPH1 YIR002C 3'-5' DNA helicase involved in error-free bypass of DNA lesions genetic 1 1 1 Negative Genetic
MSH6 YDR097C Protein required for mismatch repair in mitosis and meiosis genetic 1 1 1 Negative Genetic
MAM33 YIL070C Acidic protein of the mitochondrial matrix genetic 1 1 1 Negative Genetic
ITC1 YGL133W Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex genetic 1 1 1 Positive Genetic
NPL4 YBR170C Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase genetic 1 1 1 Negative Genetic
ORC1 YML065W Largest subunit of the origin recognition complex genetic 1 1 1 Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
HTA1 YDR225W Histone H2A genetic 1 1 1 Negative Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
CTI6 YPL181W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
MAF1 YDR005C Highly conserved negative regulator of RNA polymerase III genetic 1 1 1 Negative Genetic
NUM1 YDR150W Protein required for nuclear migration genetic 1 1 1 Negative Genetic
NGG1 YDR176W Subunit of chromatin modifying histone acetyltransferase complexes genetic 1 1 1 Positive Genetic
MGA2 YIR033W ER membrane protein involved in regulation of OLE1 transcription genetic 1 1 1 Negative Genetic
DAL3 YIR032C Ureidoglycolate lyase genetic 1 1 1 Negative Genetic
MCM2 YBL023C Protein involved in DNA replication physical 1 1 1 Reconstituted Complex
MCM2 YBL023C Protein involved in DNA replication genetic 1 1 1 Negative Genetic
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis genetic 1 1 1 Negative Genetic
FUN30 YAL019W Snf2p family member with ATP-dependent chromatin remodeling activity genetic 1 1 1 Negative Genetic
FIN1 YDR130C Spindle pole body-related intermediate filament protein genetic 1 1 1 Negative Genetic
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
FKH1 YIL131C Forkhead family transcription factor physical 1 1 1 Affinity Capture-Western
ACS2 YLR153C Acetyl-coA synthetase isoform genetic 1 1 1 Negative Genetic
BUL1 YMR275C Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex genetic 1 1 1 Negative Genetic
IPA1 YJR141W Protein implicated in pre-mRNA processing and proteasomal degradation genetic 1 1 1 Negative Genetic
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 1 1 1 Positive Genetic
ADD66 YKL206C Protein involved in 20S proteasome assembly genetic 1 1 1 Positive Genetic
HIR1 YBL008W Subunit of the HIR complex genetic 1 1 1 Negative Genetic
CAC2 YML102W Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p genetic 1 1 1 Negative Genetic
DIA2 YOR080W Origin-binding F-box protein genetic 1 1 1 Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 1 1 1 Negative Genetic
HAP3 YBL021C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Negative Genetic
MMS4 YBR098W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 1 1 1 Negative Genetic
ISA1 YLL027W Protein required for maturation of mitochondrial [4Fe-4S] proteins genetic 1 1 1 Negative Genetic
FCF1 YDR339C PINc domain endonuclease genetic 1 1 1 Negative Genetic
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 1 1 1 Negative Genetic
IME2 YJL106W Serine/threonine protein kinase involved in activation of meiosis physical 1 1 1 Biochemical Activity
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 1 1 1 Negative Genetic
DAL82 YNL314W Positive regulator of allophanate inducible genes genetic 1 1 1 Negative Genetic
MCM10 YIL150C Essential chromatin-associated protein physical 1 1 1 Reconstituted Complex
MCM10 YIL150C Essential chromatin-associated protein genetic 1 1 1 Negative Genetic
BIM1 YER016W Microtubule plus end-tracking protein genetic 1 1 1 Negative Genetic
MSN5 YDR335W Karyopherin genetic 1 1 1 Negative Genetic
CLG1 YGL215W Cyclin-like protein that interacts with Pho85p genetic 1 1 1 Negative Genetic
ASK1 YKL052C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
APC11 YDL008W Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
CDC21 YOR074C Thymidylate synthase genetic 1 1 1 Negative Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 1 1 1 Negative Genetic
HPC2 YBR215W Subunit of the HIR complex genetic 1 1 1 Negative Genetic
CSE4 YKL049C Centromeric histone H3-like protein genetic 1 1 1 Negative Genetic
MIF2 YKL089W Centromeric CDEIII region binding protein genetic 1 1 1 Negative Genetic
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 1 1 1 Negative Genetic
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase physical 1 1 1 Affinity Capture-MS
ECO1 YFR027W Acetyltransferase required for sister chromatid cohesion genetic 1 1 1 Negative Genetic
HXK2 YGL253W Hexokinase isoenzyme 2 genetic 1 1 1 Negative Genetic
MAD1 YGL086W Coiled-coil protein involved in spindle-assembly checkpoint genetic 1 1 1 Negative Genetic
MCM3 YEL032W Protein involved in DNA replication genetic 1 1 1 Negative Genetic
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
BUD2 YKL092C GTPase activating factor for Rsr1p/Bud1p genetic 1 1 1 Negative Genetic
BUD6 YLR319C Actin- and formin-interacting protein genetic 1 1 1 Negative Genetic
MON1 YGL124C Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
KEX2 YNL238W Kexin, a subtilisin-like protease (proprotein convertase) genetic 1 1 1 Negative Genetic
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
CIN2 YPL241C GTPase-activating protein (GAP) for Cin4p genetic 1 1 1 Negative Genetic
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 1 1 1 Positive Genetic
GDH3 YAL062W NADP(+)-dependent glutamate dehydrogenase genetic 1 1 1 Negative Genetic
GAB1 YLR459W Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Positive Genetic
MEU1 YLR017W Methylthioadenosine phosphorylase (MTAP) genetic 1 1 1 Negative Genetic
IDS2 YJL146W Protein involved in modulation of Ime2p activity during meiosis genetic 1 1 1 Negative Genetic
HCM1 YCR065W Forkhead transcription factor genetic 1 1 1 Negative Genetic
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Positive Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-MS
ORC4 YPR162C Subunit of the origin recognition complex (ORC) physical 1 1 1 Affinity Capture-MS
TAH11 YJR046W DNA replication licensing factor physical 1 1 1 Reconstituted Complex
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
PBN1 YCL052C Component of glycosylphosphatidylinositol-mannosyltransferase I genetic 1 1 1 Positive Genetic
SNM1 YDR478W Ribonuclease MRP complex subunit genetic 1 1 1 Positive Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Positive Genetic
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER genetic 1 1 1 Positive Genetic
SIW14 YNL032W Inositol phosphatase involved in inositol pyrophosphate metabolism genetic 1 1 1 Positive Genetic
RIP1 YEL024W Ubiquinol-cytochrome-c reductase genetic 1 1 1 Positive Genetic
QCR9 YGR183C Subunit 9 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Positive Genetic
SIP5 YMR140W Protein of unknown function genetic 1 1 1 Positive Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Positive Genetic
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 1 1 1 Negative Genetic
PGI1 YBR196C Glycolytic enzyme phosphoglucose isomerase genetic 1 1 1 Negative Genetic
RSC6 YCR052W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
SEC31 YDL195W Component of the Sec13p-Sec31p complex of the COPII vesicle coat genetic 1 1 1 Negative Genetic
PSF1 YDR013W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 1 1 1 Negative Genetic
STN1 YDR082W Telomere end-binding and capping protein genetic 1 1 1 Negative Genetic
TAF10 YDR167W Subunit (145 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
SCC2 YDR180W Subunit of cohesin loading factor (Scc2p-Scc4p) genetic 1 1 1 Negative Genetic
PCF11 YDR228C mRNA 3' end processing factor genetic 1 1 1 Negative Genetic
SLD5 YDR489W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 1 1 1 Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
SPT15 YER148W TATA-binding protein (TBP) genetic 1 1 1 Negative Genetic
TUB2 YFL037W Beta-tubulin genetic 1 1 1 Negative Genetic
SPT6 YGR116W Nucleosome remodeling protein genetic 1 1 1 Negative Genetic
PTI1 YGR156W Essential component of CPF (cleavage and polyadenylation factor) genetic 1 1 1 Negative Genetic
QNS1 YHR074W Glutamine-dependent NAD(+) synthetase genetic 1 1 1 Negative Genetic
RRN7 YJL025W Component of the core factor (CF) rDNA transcription factor complex genetic 1 1 1 Negative Genetic
SRP102 YKL154W Signal recognition particle (SRP) receptor beta subunit genetic 1 1 1 Negative Genetic
PRP16 YKR086W DEAH-box RNA helicase genetic 1 1 1 Negative Genetic
RSC58 YLR033W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 1 1 1 Negative Genetic
SMC4 YLR086W Subunit of the condensin complex genetic 1 1 1 Negative Genetic
SFH1 YLR321C Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
UTP21 YLR409C Subunit of U3-containing 90S preribosome and SSU processome complexes genetic 1 1 1 Negative Genetic
SEN1 YLR430W ATP-dependent 5' to 3' RNA/DNA and DNA helicase genetic 1 1 1 Negative Genetic
RSC9 YML127W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 1 1 1 Negative Genetic
PGA2 YNL149C Essential protein required for maturation of Gas1p and Pho8p genetic 1 1 1 Negative Genetic
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Negative Genetic
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
RPB11 YOL005C RNA polymerase II subunit B12.5 genetic 1 1 1 Negative Genetic
RFC1 YOR217W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
SPC19 YDR201W Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
TRS23 YDR246W Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Negative Genetic
STS1 YIR011C Protein required for localizing proteasomes to the nucleus genetic 1 1 1 Negative Genetic
RFC2 YJR068W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
PDS5 YMR076C Cohesion maintenance factor genetic 1 1 1 Negative Genetic
PER1 YCR044C Protein of the endoplasmic reticulum genetic 1 1 1 Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Negative Genetic
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 1 1 1 Negative Genetic
RTT103 YDR289C Protein involved in transcription termination by RNA polymerase II genetic 1 1 1 Negative Genetic
PUF4 YGL014W Member of the PUF protein family genetic 1 1 1 Negative Genetic
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 1 1 1 Negative Genetic
SKN1 YGR143W Protein involved in sphingolipid biosynthesis genetic 1 1 1 Negative Genetic
PBP1 YGR178C Component of glucose deprivation induced stress granules genetic 1 1 1 Negative Genetic
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 1 1 1 Negative Genetic
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 1 1 1 Negative Genetic
RRD1 YIL153W Peptidyl-prolyl cis/trans-isomerase genetic 1 1 1 Negative Genetic
YAK1 YJL141C Serine-threonine protein kinase genetic 1 1 1 Negative Genetic
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 1 1 1 Negative Genetic
POL32 YJR043C Third subunit of DNA polymerase delta genetic 1 1 1 Negative Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Negative Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Negative Genetic
TDA5 YLR426W Putative protein of unknown function genetic 1 1 1 Negative Genetic
SUB1 YMR039C Transcriptional regulator genetic 1 1 1 Negative Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Negative Genetic
TLG2 YOL018C Syntaxin-like t-SNARE genetic 1 1 1 Negative Genetic
WHI5 YOR083W Repressor of G1 transcription genetic 1 1 1 Negative Genetic
PAC1 YOR269W Regulator of dynein, involved in intracellular transport genetic 1 1 1 Negative Genetic
RIM20 YOR275C Protein involved in proteolytic activation of Rim101p genetic 1 1 1 Negative Genetic
RTC6 YPL183W-A Protein involved in translation genetic 1 1 1 Negative Genetic
PUS1 YPL212C tRNA:pseudouridine synthase genetic 1 1 1 Negative Genetic
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 1 1 1 Negative Genetic
PDX3 YBR035C Pyridoxine (pyridoxamine) phosphate oxidase genetic 1 1 1 Negative Genetic
TKL2 YBR117C Transketolase genetic 1 1 1 Negative Genetic
YBR238C YBR238C Mitochondrial membrane protein genetic 1 1 1 Negative Genetic
STP22 YCL008C Component of the ESCRT-I complex genetic 1 1 1 Negative Genetic
YDL218W YDL218W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YDL241W YDL241W Putative protein of unknown function genetic 1 1 1 Negative Genetic
SNQ2 YDR011W Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Negative Genetic
RAD61 YDR014W Subunit of a complex that inhibits sister chromatid cohesion genetic 1 1 1 Negative Genetic
PST1 YDR055W Cell wall protein that contains a putative GPI-attachment site genetic 1 1 1 Negative Genetic
YDR061W YDR061W Protein with similarity to ABC transporter family members genetic 1 1 1 Negative Genetic
SWF1 YDR126W Palmitoyltransferase that acts on transmembrane proteins genetic 1 1 1 Negative Genetic
RPA14 YDR156W RNA polymerase I subunit A14 genetic 1 1 1 Negative Genetic
REF2 YDR195W RNA-binding protein genetic 1 1 1 Negative Genetic
SSD1 YDR293C Translational repressor genetic 1 1 1 Negative Genetic
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 1 1 1 Negative Genetic
SIZ1 YDR409W SUMO E3 ligase genetic 1 1 1 Negative Genetic
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class genetic 1 1 1 Negative Genetic
VHR2 YER064C Non-essential nuclear protein genetic 1 1 1 Negative Genetic
UBP5 YER144C Putative ubiquitin-specific protease genetic 1 1 1 Negative Genetic
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex genetic 1 1 1 Negative Genetic
YRB30 YGL164C RanGTP-binding protein genetic 1 1 1 Negative Genetic
TWF1 YGR080W Twinfilin genetic 1 1 1 Negative Genetic
PHB1 YGR132C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 1 1 1 Negative Genetic
YAP1802 YGR241C Protein of the AP180 family, involved in clathrin cage assembly genetic 1 1 1 Negative Genetic
SPO12 YHR152W Nucleolar protein of unknown function genetic 1 1 1 Negative Genetic
SET4 YJL105W Chromatin-associated protein involved in control of stress response genetic 1 1 1 Negative Genetic
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 1 1 1 Negative Genetic
REC107 YJR021C Protein involved in early stages of meiotic recombination genetic 1 1 1 Negative Genetic
SPT23 YKL020C ER membrane protein involved in regulation of OLE1 transcription genetic 1 1 1 Negative Genetic
YLR012C YLR012C Putative protein of unknown function genetic 1 1 1 Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Negative Genetic
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 1 1 1 Negative Genetic
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Negative Genetic
RPL6A YML073C Ribosomal 60S subunit protein L6A genetic 1 1 1 Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
VPS17 YOR132W Subunit of the membrane-associated retromer complex genetic 1 1 1 Negative Genetic
VTC3 YPL019C Regulatory subunit of the vacuolar transporter chaperone (VTC) complex genetic 1 1 1 Negative Genetic
TPK2 YPL203W cAMP-dependent protein kinase catalytic subunit genetic 1 1 1 Negative Genetic
QDR3 YBR043C Multidrug transporter of the major facilitator superfamily genetic 1 1 1 Positive Genetic
SKI8 YGL213C Ski complex component and WD-repeat protein genetic 1 1 1 Positive Genetic
RUD3 YOR216C Golgi matrix protein genetic 1 1 1 Positive Genetic
SEC7 YDR170C Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors genetic 1 1 1 Negative Genetic
SAE2 YGL175C Endonuclease required for telomere elongation genetic 1 1 1 Negative Genetic
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 1 1 1 Positive Genetic
SRN2 YLR119W Component of the ESCRT-I complex genetic 1 1 1 Negative Genetic
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 1 1 1 Negative Genetic
RNH202 YDR279W Ribonuclease H2 subunit genetic 1 1 1 Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Positive Genetic
RIF1 YBR275C Protein involved in control of DNA replication genetic 1 1 1 Phenotypic Enhancement
ELF1 YKL160W Transcription elongation factor with a conserved zinc finger domain genetic 1 1 1 Negative Genetic
LIP1 YMR298W Ceramide synthase subunit genetic 1 1 1 Negative Genetic
DFG16 YOR030W Probable multiple transmembrane protein genetic 1 1 1 Negative Genetic
KIP3 YGL216W Kinesin-related antiparallel sliding motor protein genetic 1 1 1 Negative Genetic
COS7 YDL248W Endosomal protein involved in turnover of plasma membrane proteins genetic 1 1 1 Negative Genetic
BIG1 YHR101C Integral membrane protein of the endoplasmic reticulum genetic 1 1 1 Positive Genetic
GPI14 YJR013W Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I genetic 1 1 1 Positive Genetic
ATO2 YNR002C Putative transmembrane protein involved in export of ammonia genetic 1 1 1 Negative Genetic
MPC3 YGR243W Highly conserved subunit of the mitochondrial pyruvate carrier (MPC) genetic 1 1 1 Negative Genetic
NCS2 YNL119W Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs genetic 1 1 1 Negative Genetic
GTF1 YGR102C Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex genetic 1 1 1 Negative Genetic
AGC1 YPR021C Mitochondrial amino acid transporter genetic 1 1 1 Negative Genetic
CDC1 YDR182W Putative mannose-ethanolamine phosphate phosphodiesterase genetic 1 1 1 Negative Genetic
DFR1 YOR236W Dihydrofolate reductase involved in tetrahydrofolate biosynthesis genetic 1 1 1 Positive Genetic
FLX1 YIL134W Mitochondrial flavin adenine dinucleotide transporter genetic 1 1 1 Negative Genetic
NPR3 YHL023C Subunit of the Iml1p/SEACIT complex genetic 1 1 1 Negative Genetic
CTS2 YDR371W Putative chitinase genetic 1 1 1 Negative Genetic
DPA10 YLR307C-A Putative mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic