Standard name Systematic name Name description Description
HST1 YOL068C NAD(+)-dependent histone deacetylase NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and meiotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance; HST1 has a paralog, SIR2, that arose from the whole genome duplication
Visualize the interactome of HST1
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Mito 0.411 0.206 0.427
Nucleolus 0.189 0.059 0.064
Nucleus 0.911 0.897 0.830

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 1440

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
HST1 3 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0767 (NAD nucleosidase nuclear)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 11 4 11 Dosage Rescue, Phenotypic Enhancement, Synthetic Growth Defect, Dosage Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes physical 6 2 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 5 2 5 Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Dosage Rescue, Phenotypic Suppression
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 4 2 4 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
SET3 YKR029C Defining member of the SET3 histone deacetylase complex physical 4 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
HOS4 YIL112W Subunit of the Set3 complex physical 4 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 3 2 3 Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue
RFM1 YOR279C Component of the Sum1p-Rfm1p-Hst1p complex physical 3 2 3 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
LDB7 YBL006C Component of the RSC chromatin remodeling complex genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
TDA5 YLR426W Putative protein of unknown function genetic 3 2 2 Positive Genetic, Synthetic Rescue, Synthetic Rescue
DYN1 YKR054C Cytoplasmic heavy chain dynein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SIF2 YBR103W WD40 repeat-containing subunit of Set3C histone deacetylase complex physical 3 1 2 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SNT1 YCR033W Set3C histone deacetylase scaffold physical 3 1 2 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 3 1 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 1 2 Negative Genetic, Negative Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 2 1 2 Negative Genetic, Negative Genetic
VRP1 YLR337C Verprolin, proline-rich actin-associated protein genetic 2 1 2 Negative Genetic, Negative Genetic
YPT6 YLR262C Rab family GTPase genetic 2 1 2 Negative Genetic, Negative Genetic
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex genetic 2 1 2 Positive Genetic, Positive Genetic
PSD1 YNL169C Phosphatidylserine decarboxylase of the mitochondrial inner membrane genetic 2 1 2 Negative Genetic, Negative Genetic
DAN4 YJR151C Cell wall mannoprotein genetic 2 1 2 Negative Genetic, Negative Genetic
BDF1 YLR399C BET family transcriptional regulator genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
BEM1 YBR200W Protein containing SH3-domains genetic 2 1 1 Negative Genetic, Negative Genetic
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
REI1 YBR267W Cytoplasmic pre-60S factor genetic 2 1 1 Negative Genetic, Negative Genetic
LYS20 YDL182W Homocitrate synthase isozyme and functions in DNA repair genetic 2 1 1 Negative Genetic, Negative Genetic
NRG1 YDR043C Transcriptional repressor genetic 2 1 1 Negative Genetic, Negative Genetic
RMA1 YKL132C Putative dihydrofolate synthetase genetic 2 1 1 Negative Genetic, Negative Genetic
PSF2 YJL072C Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 2 1 1 Negative Genetic, Negative Genetic
HTS1 YPR033C Cytoplasmic and mitochondrial histidine tRNA synthetase genetic 2 1 1 Negative Genetic, Negative Genetic
INO2 YDR123C Transcription factor genetic 2 1 1 Negative Genetic, Negative Genetic
MAC1 YMR021C Copper-sensing transcription factor genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
HOS2 YGL194C Histone deacetylase and subunit of Set3 and Rpd3L complexes physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RAD53 YPL153C DNA damage response kinase regulation 1 1 1 protein kinase assay evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Positive Genetic
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 1 1 1 Negative Genetic
CDC42 YLR229C Small rho-like GTPase genetic 1 1 1 Negative Genetic
CCA1 YER168C ATP (CTP):tRNA-specific tRNA nucleotidyltransferase genetic 1 1 1 Negative Genetic
CPR1 YDR155C Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin) physical 1 1 1 Affinity Capture-MS
ELP2 YGR200C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
STM1 YLR150W Protein required for optimal translation under nutrient stress physical 1 1 1 Affinity Capture-MS
TPM1 YNL079C Major isoform of tropomyosin physical 1 1 1 Affinity Capture-MS
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex physical 1 1 1 Affinity Capture-MS
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains physical 1 1 1 Affinity Capture-Western
TOS4 YLR183C Putative transcription factor, contains Forkhead Associated domain physical 1 1 1 Affinity Capture-Western
TOS4 YLR183C Putative transcription factor, contains Forkhead Associated domain genetic 1 1 1 Synthetic Rescue
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily physical 1 1 1 Affinity Capture-RNA
SIZ1 YDR409W SUMO E3 ligase physical 1 1 1 Affinity Capture-MS
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation physical 1 1 1 Affinity Capture-MS
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
RAD53 YPL153C DNA damage response kinase physical 1 1 1 Biochemical Activity
SSD1 YDR293C Translational repressor genetic 1 1 1 Dosage Rescue
ORC5 YNL261W Subunit of the origin recognition complex (ORC) genetic 1 1 1 Synthetic Lethality
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 1 1 1 Phenotypic Enhancement
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 1 1 1 Phenotypic Suppression
SUB1 YMR039C Transcriptional regulator genetic 1 1 1 Phenotypic Suppression
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Negative Genetic
LSM7 YNL147W Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
RGP1 YDR137W Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) genetic 1 1 1 Negative Genetic
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
MMR1 YLR190W Phosphorylated protein of the mitochondrial outer membrane genetic 1 1 1 Positive Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 1 1 1 Positive Genetic
RTT109 YLL002W Histone acetyltransferase genetic 1 1 1 Synthetic Growth Defect
MDH1 YKL085W Mitochondrial malate dehydrogenase genetic 1 1 1 Phenotypic Suppression
NDT80 YHR124W Meiosis-specific transcription factor genetic 1 1 1 Phenotypic Suppression
LCB5 YLR260W Minor sphingoid long-chain base kinase genetic 1 1 1 Negative Genetic
STB1 YNL309W Protein with role in regulation of MBF-specific transcription at Start genetic 1 1 1 Negative Genetic
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Positive Genetic
TCO89 YPL180W Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p) genetic 1 1 1 Negative Genetic
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 1 1 1 Synthetic Growth Defect
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 1 1 1 Negative Genetic
RRP6 YOR001W Nuclear exosome exonuclease component genetic 1 1 1 Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Rescue
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Phenotypic Suppression
HST2 YPL015C Cytoplasmic NAD(+)-dependent protein deacetylase genetic 1 1 1 Phenotypic Enhancement
PBN1 YCL052C Component of glycosylphosphatidylinositol-mannosyltransferase I genetic 1 1 1 Positive Genetic
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex genetic 1 1 1 Positive Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Positive Genetic
PDC2 YDR081C Transcription factor for thiamine-regulated genes genetic 1 1 1 Positive Genetic
RER1 YCL001W Protein involved in retention of membrane proteins genetic 1 1 1 Positive Genetic
RPL23B YER117W Ribosomal 60S subunit protein L23B genetic 1 1 1 Positive Genetic
ROF1 YHR177W Putative transcription factor containing a WOPR domain genetic 1 1 1 Positive Genetic
RAD61 YDR014W Subunit of a complex that inhibits sister chromatid cohesion genetic 1 1 1 Positive Genetic
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Negative Genetic
TOM20 YGR082W Component of the TOM (translocase of outer membrane) complex genetic 1 1 1 Negative Genetic
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Negative Genetic
MAK11 YKL021C Protein involved in an early step of 60S ribosomal subunit biogenesis genetic 1 1 1 Negative Genetic
ORC3 YLL004W Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
SMD2 YLR275W Core Sm protein Sm D2 genetic 1 1 1 Negative Genetic
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) genetic 1 1 1 Negative Genetic
PRP24 YMR268C Splicing factor that reanneals snRNPs during spliceosome recycling genetic 1 1 1 Negative Genetic
SRV2 YNL138W CAP (cyclase-associated protein) genetic 1 1 1 Negative Genetic
TAF3 YPL011C TFIID subunit (47 kDa) genetic 1 1 1 Negative Genetic
SMX3 YPR182W Core Sm protein Sm F genetic 1 1 1 Negative Genetic
KRR1 YCL059C Nucleolar protein required for rRNA synthesis and ribosomal assembly genetic 1 1 1 Negative Genetic
ORC1 YML065W Largest subunit of the origin recognition complex genetic 1 1 1 Negative Genetic
SEC65 YML105C Subunit of the signal recognition particle (SRP) genetic 1 1 1 Negative Genetic
ORC4 YPR162C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
STP22 YCL008C Component of the ESCRT-I complex genetic 1 1 1 Negative Genetic
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 1 1 1 Negative Genetic
VPS52 YDR484W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
RMD9 YGL107C Mitochondrial protein that controls mitochondrial gene expression genetic 1 1 1 Negative Genetic
SFB3 YHR098C Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat genetic 1 1 1 Negative Genetic
STB5 YHR178W Transcription factor genetic 1 1 1 Negative Genetic
SPO75 YLL005C Meiosis-specific protein of unknown function genetic 1 1 1 Negative Genetic
IRC25 YLR021W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 1 1 1 Negative Genetic
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Negative Genetic
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER genetic 1 1 1 Negative Genetic
PDE2 YOR360C High-affinity cyclic AMP phosphodiesterase genetic 1 1 1 Phenotypic Suppression
NDL1 YLR254C Homolog of nuclear distribution factor NudE genetic 1 1 1 Negative Genetic
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Negative Genetic
PSP2 YML017W Asn rich cytoplasmic protein that contains RGG motifs genetic 1 1 1 Negative Genetic
SMA2 YML066C Meiosis-specific prospore membrane protein genetic 1 1 1 Negative Genetic
YMR321C YMR321C Putative protein of unknown function genetic 1 1 1 Negative Genetic
VAC7 YNL054W Integral vacuolar membrane protein genetic 1 1 1 Negative Genetic
SUN4 YNL066W Cell wall protein related to glucanases localized in birth scars genetic 1 1 1 Negative Genetic
ZWF1 YNL241C Glucose-6-phosphate dehydrogenase (G6PD) genetic 1 1 1 Negative Genetic
NPL4 YBR170C Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase genetic 1 1 1 Negative Genetic
RPL35B YDL136W Ribosomal 60S subunit protein L35B genetic 1 1 1 Negative Genetic
RTG2 YGL252C Sensor of mitochondrial dysfunction genetic 1 1 1 Negative Genetic
POL32 YJR043C Third subunit of DNA polymerase delta genetic 1 1 1 Negative Genetic
MRT4 YKL009W Protein involved in mRNA turnover and ribosome assembly genetic 1 1 1 Negative Genetic
MEH1 YKR007W Subunit of the EGO/GSE complex genetic 1 1 1 Negative Genetic
VPS51 YKR020W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
MSC1 YML128C Protein of unknown function genetic 1 1 1 Negative Genetic
YOR385W YOR385W Putative protein of unknown function genetic 1 1 1 Negative Genetic
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Phenotypic Enhancement
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Synthetic Growth Defect
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Rescue
NRT1 YOR071C High-affinity nicotinamide riboside transporter genetic 1 1 1 Synthetic Rescue
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
AFG2 YLR397C ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex genetic 1 1 1 Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Positive Genetic
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 1 1 1 Synthetic Growth Defect
HOS2 YGL194C Histone deacetylase and subunit of Set3 and Rpd3L complexes genetic 1 1 1 Phenotypic Enhancement
CIR2 YOR356W Putative ortholog of human ETF-dH genetic 1 1 1 Negative Genetic
AKL1 YBR059C Ser/Thr protein kinase physical 1 1 1 Affinity Capture-MS
CSR2 YPR030W Nuclear ubiquitin protein ligase binding protein genetic 1 1 1 Negative Genetic
GPP1 YIL053W Constitutively expressed DL-glycerol-3-phosphate phosphatase genetic 1 1 1 Negative Genetic
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 1 1 1 Synthetic Rescue
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Negative Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 1 1 1 Phenotypic Suppression
FOB1 YDR110W Nucleolar protein that binds the rDNA replication fork barrier site genetic 1 1 1 Phenotypic Suppression
BOS1 YLR078C v-SNARE (vesicle specific SNAP receptor) genetic 1 1 1 Negative Genetic
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Phenotypic Suppression
ESC2 YDR363W Sumo-like domain protein genetic 1 1 1 Synthetic Growth Defect
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Synthetic Growth Defect
CSF1 YLR087C Protein with structural similarity to lipid transport protein Vps13p genetic 1 1 1 Negative Genetic
HEM12 YDR047W Uroporphyrinogen decarboxylase genetic 1 1 1 Positive Genetic
CDC50 YCR094W Endosomal protein that interacts with phospholipid flippase Drs2p genetic 1 1 1 Negative Genetic
GPI13 YLL031C ER membrane localized phosphoryltransferase genetic 1 1 1 Positive Genetic
ATG41 YPL250C Protein of unknown function genetic 1 1 1 Negative Genetic
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Positive Genetic
AAT1 YKL106W Mitochondrial aspartate aminotransferase genetic 1 1 1 Phenotypic Suppression