YKU70 |
YMR284W |
Subunit of the telomeric Ku complex (Yku70p-Yku80p) |
physical |
14 |
4 |
11 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-crystal Structure, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Co-crystal Structure |
EST1 |
YLR233C |
TLC1 RNA-associated factor involved in telomere length regulation |
genetic |
12 |
7 |
9 |
Dosage Rescue, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement, Negative Genetic, Negative Genetic |
CDC13 |
YDL220C |
Single stranded DNA-binding protein found at TG1-3 telomere G-tails |
genetic |
9 |
5 |
9 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Phenotypic Suppression, Phenotypic Suppression, Negative Genetic, Phenotypic Enhancement |
MRE11 |
YMR224C |
Nuclease subunit of the MRX complex with Rad50p and Xrs2p |
genetic |
8 |
4 |
7 |
Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Dosage Growth Defect, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement |
EST2 |
YLR318W |
Reverse transcriptase subunit of the telomerase holoenzyme |
genetic |
7 |
4 |
6 |
Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Synthetic Rescue, Synthetic Lethality, Phenotypic Suppression, Phenotypic Suppression |
SIR4 |
YDR227W |
SIR protein involved in assembly of silent chromatin domains |
physical |
7 |
4 |
5 |
Two-hybrid, Affinity Capture-Western, Two-hybrid, Two-hybrid, Reconstituted Complex, Co-crystal Structure, Reconstituted Complex |
RAD52 |
YML032C |
Protein involved in homologous recombination |
genetic |
6 |
3 |
6 |
Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Suppression |
DIA2 |
YOR080W |
Origin-binding F-box protein |
genetic |
4 |
3 |
4 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic, Phenotypic Enhancement |
TEL1 |
YBL088C |
Protein kinase primarily involved in telomere length regulation |
genetic |
4 |
2 |
4 |
Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement |
EST3 |
YIL009C-A |
Component of the telomerase holoenzyme |
genetic |
4 |
3 |
3 |
Dosage Growth Defect, Dosage Lethality, Negative Genetic, Negative Genetic |
XRS2 |
YDR369C |
FHA domain-containing component of the Mre11 complex |
genetic |
4 |
2 |
3 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement |
PIF1 |
YML061C |
DNA helicase, potent G-quadruplex DNA binder/unwinder |
genetic |
3 |
3 |
3 |
Phenotypic Enhancement, Dosage Lethality, Dosage Growth Defect |
EST1 |
YLR233C |
TLC1 RNA-associated factor involved in telomere length regulation |
physical |
3 |
2 |
3 |
Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western |
PMR1 |
YGL167C |
High affinity Ca2+/Mn2+ P-type ATPase |
genetic |
3 |
2 |
3 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic |
RAD50 |
YNL250W |
Subunit of MRX complex with Mre11p and Xrs2p |
genetic |
3 |
3 |
2 |
Phenotypic Suppression, Phenotypic Enhancement, Positive Genetic |
FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
2 |
2 |
2 |
chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence |
CDC73 |
YLR418C |
Component of the Paf1p complex |
genetic |
2 |
2 |
2 |
Negative Genetic, Phenotypic Enhancement |
DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Affinity Capture-RNA |
YKU70 |
YMR284W |
Subunit of the telomeric Ku complex (Yku70p-Yku80p) |
genetic |
2 |
2 |
2 |
Dosage Lethality, Phenotypic Enhancement |
PHO85 |
YPL031C |
Cyclin-dependent kinase |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Biochemical Activity |
RAD54 |
YGL163C |
DNA-dependent ATPase that stimulates strand exchange |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Phenotypic Enhancement |
SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Positive Genetic |
SAC3 |
YDR159W |
mRNA export factor |
genetic |
2 |
2 |
2 |
Negative Genetic, Phenotypic Enhancement |
RAD9 |
YDR217C |
DNA damage-dependent checkpoint protein |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Phenotypic Enhancement |
DBF4 |
YDR052C |
Regulatory subunit of Cdc7p-Dbf4p kinase complex |
genetic |
2 |
2 |
2 |
Negative Genetic, Phenotypic Enhancement |
EXO1 |
YOR033C |
5'-3' exonuclease and flap-endonuclease |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Phenotypic Enhancement |
HHT2 |
YNL031C |
Histone H3 |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Affinity Capture-Western |
RTT109 |
YLL002W |
Histone acetyltransferase |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Phenotypic Enhancement |
TRM2 |
YKR056W |
tRNA methyltransferase |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Phenotypic Enhancement |
NPL3 |
YDR432W |
RNA-binding protein |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
DEP1 |
YAL013W |
Component of the Rpd3L histone deacetylase complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
YPT31 |
YER031C |
Rab family GTPase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
ENV9 |
YOR246C |
Conserved oxidoreductase involved in lipid droplet morphology |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CMR1 |
YDL156W |
Nuclear protein with role in transcription, protein quality control |
physical |
2 |
2 |
1 |
Affinity Capture-MS, Co-fractionation |
RFA1 |
YAR007C |
Subunit of heterotrimeric Replication Protein A (RPA) |
physical |
2 |
1 |
1 |
Affinity Capture-Western, Affinity Capture-Western |
NEJ1 |
YLR265C |
DNA end-binding protein required for nonhomologous end joining (NHEJ) |
physical |
2 |
1 |
1 |
Affinity Capture-Western, Affinity Capture-Western |
SUA5 |
YGL169W |
Protein involved in threonylcarbamoyl adenosine biosynthesis |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
MOT3 |
YMR070W |
Transcriptional repressor, activator |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
CTR9 |
YOL145C |
Component of the Paf1p complex involved in transcription elongation |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
PAF1 |
YBR279W |
Component of the Paf1p complex involved in transcription elongation |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
TAF14 |
YPL129W |
Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
NSE3 |
YDR288W |
Component of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
KRE29 |
YER038C |
Subunit of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
NSE4 |
YDL105W |
Component of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
BRE1 |
YDL074C |
E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
FUN12 |
YAL035W |
Translation initiation factor eIF5B |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CDC48 |
YDL126C |
AAA ATPase with protein-unfoldase activity |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
RPC40 |
YPR110C |
RNA polymerase subunit AC40 |
genetic |
1 |
1 |
1 |
Positive Genetic |
RET1 |
YOR207C |
Second-largest subunit of RNA polymerase III |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MFT1 |
YML062C |
Subunit of the THO complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SUB2 |
YDL084W |
Component of the TREX complex required for nuclear mRNA export |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
THP2 |
YHR167W |
Subunit of the THO and TREX complexes |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SPT16 |
YGL207W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPN12 |
YFR052W |
Subunit of the 19S regulatory particle of the 26S proteasome lid |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPN7 |
YPR108W |
Essential non-ATPase regulatory subunit of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
PRE1 |
YER012W |
Beta 4 subunit of the 20S proteasome |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
ACC1 |
YNR016C |
Acetyl-CoA carboxylase, biotin containing enzyme |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ARO1 |
YDR127W |
Pentafunctional arom protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
CDC45 |
YLR103C |
DNA replication initiation factor |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
HDA1 |
YNL021W |
Catalytic subunit of class II HDA1 histone deacetylase complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
NOG2 |
YNR053C |
Putative GTPase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
AVO1 |
YOL078W |
Component of the membrane-bound TORC2 complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
COP1 |
YDL145C |
Alpha subunit of COPI vesicle coatomer complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CTF18 |
YMR078C |
Subunit of a complex with Ctf8p |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
CTK1 |
YKL139W |
Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
DPB2 |
YPR175W |
Second largest subunit of DNA polymerase II (DNA polymerase epsilon) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HHF1 |
YBR009C |
Histone H4 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HRP1 |
YOL123W |
Subunit of cleavage factor I |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
HHF2 |
YNL030W |
Histone H4 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HST1 |
YOL068C |
NAD(+)-dependent histone deacetylase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
HTB2 |
YBL002W |
Histone H2B |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
CLU1 |
YMR012W |
Subunit of the eukaryotic translation initiation factor 3 (eIF3) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
LST8 |
YNL006W |
Protein required for the transport of Gap1p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MCM5 |
YLR274W |
Component of the Mcm2-7 hexameric helicase complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
MED1 |
YPR070W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
MED6 |
YHR058C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
HDA3 |
YPR179C |
Subunit of HDA1 histone deacetylase complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
MPH1 |
YIR002C |
3'-5' DNA helicase involved in error-free bypass of DNA lesions |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
HTZ1 |
YOL012C |
Histone variant H2AZ |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
LYS12 |
YIL094C |
Homo-isocitrate dehydrogenase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NHP10 |
YDL002C |
Non-essential INO80 chromatin remodeling complex subunit |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
IES5 |
YER092W |
Non-essential INO80 chromatin remodeling complex subunit |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
IES1 |
YFL013C |
Subunit of the INO80 chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
HMO1 |
YDR174W |
Chromatin associated high mobility group (HMG) family member |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
PCF11 |
YDR228C |
mRNA 3' end processing factor |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
MGS1 |
YNL218W |
Protein with DNA-dependent ATPase and ssDNA annealing activities |
genetic |
1 |
1 |
1 |
Positive Genetic |
POL1 |
YNL102W |
Catalytic subunit of the DNA polymerase I alpha-primase complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
HTA1 |
YDR225W |
Histone H2A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HTA1 |
YDR225W |
Histone H2A |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
HTA2 |
YBL003C |
Histone H2A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CPA2 |
YJR109C |
Large subunit of carbamoyl phosphate synthetase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RAD51 |
YER095W |
Strand exchange protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
RFC2 |
YJR068W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
RFC4 |
YOL094C |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
RFC5 |
YBR087W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
MED8 |
YBR193C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
IWR1 |
YDL115C |
RNA polymerase II transport factor, conserved from yeast to humans |
genetic |
1 |
1 |
1 |
Positive Genetic |
RCO1 |
YMR075W |
Essential component of the Rpd3S histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
PUP3 |
YER094C |
Beta 3 subunit of the 20S proteasome |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CDC6 |
YJL194W |
Essential ATP-binding protein required for DNA replication |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
NUP84 |
YDL116W |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Positive Genetic |
SEC26 |
YDR238C |
Essential beta-coat protein of the COPI coatomer |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SEC23 |
YPR181C |
GTPase-activating protein, stimulates the GTPase activity of Sar1p |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SAP30 |
YMR263W |
Component of Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SIN3 |
YOL004W |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SIR2 |
YDL042C |
Conserved NAD+ dependent histone deacetylase of the Sirtuin family |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SLC1 |
YDL052C |
1-acyl-sn-glycerol-3-phosphate acyltransferase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SIP1 |
YDR422C |
One of three alternate beta-subunits of the Snf1p kinase complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SNF5 |
YBR289W |
Subunit of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SGF73 |
YGL066W |
Subunit of DUBm module of SAGA and SLIK |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SRP54 |
YPR088C |
Signal recognition particle (SRP) subunit (homolog of mammalian SRP54) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SGV1 |
YPR161C |
Cyclin (Bur2p)-dependent protein kinase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
TAF13 |
YML098W |
TFIID subunit (19 kDa) |
genetic |
1 |
1 |
1 |
Negative Genetic |
MCM2 |
YBL023C |
Protein involved in DNA replication |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
TPS1 |
YBR126C |
Synthase subunit of trehalose-6-P synthase/phosphatase complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RAD10 |
YML095C |
Single-stranded DNA endonuclease (with Rad1p) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SAW1 |
YAL027W |
5'- and 3'-flap DNA binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
BRE2 |
YLR015W |
Subunit of COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
PIN4 |
YBL051C |
Protein involved in G2/M phase progression and response to DNA damage |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
YAP1 |
YML007W |
Basic leucine zipper (bZIP) transcription factor |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
GPH1 |
YPR160W |
Glycogen phosphorylase required for the mobilization of glycogen |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ADR1 |
YDR216W |
Carbon source-responsive zinc-finger transcription factor |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ATP3 |
YBR039W |
Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
LAM5 |
YFL042C |
Putative sterol transfer protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
FOL2 |
YGR267C |
GTP-cyclohydrolase I, catalyzes first step in folic acid biosynthesis |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
IDH1 |
YNL037C |
Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
STI1 |
YOR027W |
Evolutionarily-conserved Hsp90 cochaperone |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HTB1 |
YDR224C |
Histone H2B |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
OYE2 |
YHR179W |
Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PST2 |
YDR032C |
FMN-dependent NAD(P)H:quinone oxidoreductase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
POR1 |
YNL055C |
Mitochondrial porin (voltage-dependent anion channel) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
FKH1 |
YIL131C |
Forkhead family transcription factor |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
CCT5 |
YJR064W |
Subunit of the cytosolic chaperonin Cct ring complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CDC9 |
YDL164C |
DNA ligase I found in nucleus and mitochondria |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SLX5 |
YDL013W |
Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
TOP2 |
YNL088W |
Topoisomerase II |
genetic |
1 |
1 |
1 |
Dosage Lethality |
RAD55 |
YDR076W |
Protein that stimulates strand exchange |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
ECM10 |
YEL030W |
Heat shock protein of the Hsp70 family |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
DDC1 |
YPL194W |
DNA damage checkpoint protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SOD2 |
YHR008C |
Mitochondrial manganese superoxide dismutase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
DSS1 |
YMR287C |
3'-5' exoribonuclease |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TSA2 |
YDR453C |
Stress inducible cytoplasmic thioredoxin peroxidase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
YHR033W |
YHR033W |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
YMR226C |
YMR226C |
NADP(+)-dependent serine dehydrogenase and carbonyl reductase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
YML020W |
YML020W |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
YPR003C |
YPR003C |
Putative sulfate permease |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
YTH1 |
YPR107C |
Essential RNA-binding component of cleavage and polyadenylation factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
YND1 |
YER005W |
Apyrase with wide substrate specificity |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
MTC5 |
YDR128W |
Subunit of SEACAT, a subcomplex of the SEA complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
APT1 |
YML022W |
Adenine phosphoribosyltransferase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CCT3 |
YJL014W |
Subunit of the cytosolic chaperonin Cct ring complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
KNS1 |
YLL019C |
Protein kinase involved in negative regulation of PolIII transcription |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SMC6 |
YLR383W |
Subunit of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
NPA3 |
YJR072C |
Member of the conserved GPN-loop GTPase family |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
DNL4 |
YOR005C |
DNA ligase required for nonhomologous end-joining (NHEJ) |
physical |
1 |
1 |
1 |
Two-hybrid |
GAL7 |
YBR018C |
Galactose-1-phosphate uridyl transferase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PDX1 |
YGR193C |
E3-binding protein of the mitochondrial pyruvate dehydrogenase complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TEM1 |
YML064C |
GTPase involved in initiation of Mitotic Exit Network (MEN) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RAD24 |
YER173W |
Checkpoint protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
CAC2 |
YML102W |
Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
HHT1 |
YBR010W |
Histone H3 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HHO1 |
YPL127C |
Histone H1, linker histone with roles in meiosis and sporulation |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
CTF4 |
YPR135W |
Chromatin-associated protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
DPB11 |
YJL090C |
DNA replication initiation protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
MRE11 |
YMR224C |
Nuclease subunit of the MRX complex with Rad50p and Xrs2p |
physical |
1 |
1 |
1 |
Two-hybrid |
SIS1 |
YNL007C |
Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MKK2 |
YPL140C |
MAPKK involved in the protein kinase C signaling pathway |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
BEM4 |
YPL161C |
Protein involved in establishment of cell polarity and bud emergence |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
RAD59 |
YDL059C |
Protein involved DNA double-strand break repair |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
ILV2 |
YMR108W |
Acetolactate synthase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
LSC1 |
YOR142W |
Alpha subunit of succinyl-CoA ligase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SEC4 |
YFL005W |
Rab family GTPase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
ELG1 |
YOR144C |
Subunit of an alternative replication factor C complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SPT2 |
YER161C |
Protein involved in negative regulation of transcription |
genetic |
1 |
1 |
1 |
Dosage Rescue |
SSN8 |
YNL025C |
Cyclin-like component of RNA polymerase II holoenzyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
MCK1 |
YNL307C |
Dual-specificity ser/thr and tyrosine protein kinase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PTC2 |
YER089C |
Type 2C protein phosphatase (PP2C) |
genetic |
1 |
1 |
1 |
Dosage Rescue |
LIF1 |
YGL090W |
Component of the DNA ligase IV complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
RLF2 |
YPR018W |
Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
DEF1 |
YKL054C |
RNAPII degradation factor |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HFL1 |
YKR051W |
Vacuole membrane protein that interacts with Atg8p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RRP3 |
YHR065C |
Protein involved in rRNA processing |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MET16 |
YPR167C |
3'-phosphoadenylsulfate reductase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
YBT1 |
YLL048C |
Transporter of the ATP-binding cassette (ABC) family |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
YGR266W |
YGR266W |
Protein of unknown function |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PHO86 |
YJL117W |
Endoplasmic reticulum (ER) resident protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TFC7 |
YOR110W |
RNA pol III transcription initiation factor complex (TFIIIC) subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CMG1 |
YLR271W |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MRX1 |
YER077C |
Protein that associates with mitochondrial ribosome |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SLX1 |
YBR228W |
Endonuclease involved in DNA recombination and repair |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
VMA8 |
YEL051W |
Subunit D of the V1 peripheral membrane domain of V-ATPase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CDC7 |
YDL017W |
S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
NUP133 |
YKR082W |
Subunit of Nup84p subcomplex of nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
PSO2 |
YMR137C |
Nuclease required for DNA single- and double-strand break repair |
genetic |
1 |
1 |
1 |
Negative Genetic |
RNH203 |
YLR154C |
Ribonuclease H2 subunit |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
MMS22 |
YLR320W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SIR3 |
YLR442C |
Silencing protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SIR4 |
YDR227W |
SIR protein involved in assembly of silent chromatin domains |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SIR1 |
YKR101W |
Protein involved in silencing at mating-type loci HML and HMR |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
CSM2 |
YIL132C |
Subunit of the Shu complex (aka PCSS complex) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
CIN4 |
YMR138W |
GTP-binding protein involved in beta-tubulin (Tub2p) folding |
genetic |
1 |
1 |
1 |
Negative Genetic |
MCM10 |
YIL150C |
Essential chromatin-associated protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SMT3 |
YDR510W |
Ubiquitin-like protein of the SUMO family |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
HST3 |
YOR025W |
Sirtuin, histone H3 deacetylase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
COG2 |
YGR120C |
Essential component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
CSM3 |
YMR048W |
Replication fork associated factor |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SAE2 |
YGL175C |
Endonuclease required for telomere elongation |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
UBC9 |
YDL064W |
SUMO-conjugating enzyme involved in the Smt3p conjugation pathway |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SEC10 |
YLR166C |
Essential 100kDa subunit of the exocyst complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SMC5 |
YOL034W |
Subunit of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
OCA2 |
YNL056W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
AIM4 |
YBR194W |
Protein proposed to be associated with the nuclear pore complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SIW14 |
YNL032W |
Inositol phosphatase involved in inositol pyrophosphate metabolism |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
APC5 |
YOR249C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
COG6 |
YNL041C |
Component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
RSC1 |
YGR056W |
Component of the RSC chromatin remodeling complex |
physical |
1 |
1 |
1 |
Two-hybrid |
BRE5 |
YNR051C |
Ubiquitin protease cofactor |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SUS1 |
YBR111W-A |
Global transcriptional regulator, component of SAGA, TREX-2 complexes |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
MSN2 |
YMR037C |
Stress-responsive transcriptional activator |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
TAF4 |
YMR005W |
TFIID subunit (48 kDa) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
IES2 |
YNL215W |
Protein that associates with the INO80 chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
CLB5 |
YPR120C |
B-type cyclin involved in DNA replication during S phase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
CTF8 |
YHR191C |
Subunit of a complex with Ctf18p |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
MCM3 |
YEL032W |
Protein involved in DNA replication |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
ORC3 |
YLL004W |
Subunit of the origin recognition complex (ORC) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
RAD17 |
YOR368W |
Checkpoint protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
RAD5 |
YLR032W |
DNA helicase/Ubiquitin ligase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SEC6 |
YIL068C |
Essential 88kDa subunit of the exocyst complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SKN7 |
YHR206W |
Nuclear response regulator and transcription factor |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
UFE1 |
YOR075W |
t-SNARE protein required for retrograde vesicular traffic |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
STN1 |
YDR082W |
Telomere end-binding and capping protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
TIP20 |
YGL145W |
Peripheral membrane protein required for COPI vesicle fusion to the ER |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
VTI1 |
YMR197C |
Protein involved in cis-Golgi membrane traffic |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
YCG1 |
YDR325W |
Subunit of the condensin complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
VPS41 |
YDR080W |
Subunit of the HOPS endocytic tethering complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
HRB1 |
YNL004W |
Poly(A+) RNA-binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
SEC16 |
YPL085W |
COPII vesicle coat protein required for ER transport vesicle budding |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SEC5 |
YDR166C |
Essential 107kDa subunit of the exocyst complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SRM1 |
YGL097W |
Nucleotide exchange factor for Gsp1p |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
POL32 |
YJR043C |
Third subunit of DNA polymerase delta |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
POL3 |
YDL102W |
Catalytic subunit of DNA polymerase delta |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
POL31 |
YJR006W |
Subunit of DNA polymerase delta (polymerase III) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
MCM7 |
YBR202W |
Component of the Mcm2-7 hexameric helicase complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
DOT1 |
YDR440W |
Nucleosomal histone H3-Lys79 methylase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
REV3 |
YPL167C |
Catalytic subunit of DNA polymerase zeta |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
LRS4 |
YDR439W |
Nucleolar protein that forms a complex with Csm1p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PRI1 |
YIR008C |
Subunit of DNA primase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
TOF1 |
YNL273W |
Subunit of a replication-pausing checkpoint complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SEC39 |
YLR440C |
Component of the Dsl1p tethering complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
MRC1 |
YCL061C |
S-phase checkpoint protein required for DNA replication |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
MMS1 |
YPR164W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SEC8 |
YPR055W |
Essential 121 kDa subunit of the exocyst complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
RFA2 |
YNL312W |
Subunit of heterotrimeric Replication Protein A (RPA) |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
RFA2 |
YNL312W |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
1 |
1 |
1 |
Negative Genetic |
DCC1 |
YCL016C |
Subunit of a complex with Ctf8p and Ctf18p |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SWD3 |
YBR175W |
Essential subunit of the COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
1 |
1 |
1 |
Positive Genetic |
TFC6 |
YDR362C |
Subunit of RNA polymerase III transcription initiation factor complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TSA1 |
YML028W |
Thioredoxin peroxidase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SLX8 |
YER116C |
Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
UBP3 |
YER151C |
Ubiquitin-specific protease that cleaves Ub-protein fusions |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
FCY21 |
YER060W |
Putative purine-cytosine permease |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
RTT101 |
YJL047C |
Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
MEF2 |
YJL102W |
Mitochondrial elongation factor involved in translational elongation |
genetic |
1 |
1 |
1 |
Negative Genetic |
CGI121 |
YML036W |
Component of the EKC/KEOPS complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
SLX4 |
YLR135W |
Endonuclease involved in processing DNA |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
TDP1 |
YBR223C |
Tyrosyl-DNA phosphodiesterase I |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PRI2 |
YKL045W |
Subunit of DNA primase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
YGR130C |
YGR130C |
Component of the eisosome with unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
RTR1 |
YER139C |
Dual specificity protein phosphatase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
OCA5 |
YHL029C |
Cytoplasmic protein required for replication of Brome mosaic virus |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
RTT107 |
YHR154W |
BRCA1 C-terminal domain protein needed for recovery from DNA damage |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
MSN4 |
YKL062W |
Stress-responsive transcriptional activator |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
GUP1 |
YGL084C |
Plasma membrane protein involved in remodeling GPI anchors |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SKY1 |
YMR216C |
SR protein kinase (SRPK) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
HUR1 |
YGL168W |
Protein with a role in DNA repair |
genetic |
1 |
1 |
1 |
Negative Genetic |
THO1 |
YER063W |
Conserved nuclear RNA-binding protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
RAD57 |
YDR004W |
Protein that stimulates strand exchange |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
EST2 |
YLR318W |
Reverse transcriptase subunit of the telomerase holoenzyme |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
HVG1 |
YER039C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
MPS3 |
YJL019W |
Nuclear envelope protein |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
SIC1 |
YLR079W |
Cyclin-dependent kinase inhibitor (CKI) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
VPS24 |
YKL041W |
One of four subunits of the ESCRT-III complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
DAL2 |
YIR029W |
Allantoicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
TEL2 |
YGR099W |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
TAH11 |
YJR046W |
DNA replication licensing factor |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
YKL069W |
YKL069W |
Methionine-R-sulfoxide reductase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
YEA4 |
YEL004W |
Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
TSC11 |
YER093C |
Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) |
genetic |
1 |
1 |
1 |
Positive Genetic |
SLD3 |
YGL113W |
Protein involved in the initiation of DNA replication |
genetic |
1 |
1 |
1 |
Negative Genetic |
RTT105 |
YER104W |
Chaperone for Replication Protein A complex (RPA) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
UBC13 |
YDR092W |
E2 ubiquitin-conjugating enzyme |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
PDE2 |
YOR360C |
High-affinity cyclic AMP phosphodiesterase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TOP3 |
YLR234W |
DNA Topoisomerase III |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
RRM3 |
YHR031C |
DNA helicase involved in rDNA replication and Ty1 transposition |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
UPF3 |
YGR072W |
Component of the nonsense-mediated mRNA decay (NMD) pathway |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
TSC3 |
YBR058C-A |
Protein that stimulates the activity of serine palmitoyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
TRP4 |
YDR354W |
Anthranilate phosphoribosyl transferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
URA6 |
YKL024C |
Uridylate kinase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
YGL114W |
YGL114W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
ROF1 |
YHR177W |
Putative transcription factor containing a WOPR domain |
genetic |
1 |
1 |
1 |
Negative Genetic |