SIZ1 |
YDR409W |
SUMO E3 ligase |
physical |
14 |
4 |
12 |
Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Biochemical Activity, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex |
NFI1 |
YOR156C |
SUMO E3 ligase |
physical |
12 |
3 |
11 |
Reconstituted Complex, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Biochemical Activity, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex |
SMT3 |
YDR510W |
Ubiquitin-like protein of the SUMO family |
physical |
9 |
5 |
7 |
Two-hybrid, Reconstituted Complex, Co-crystal Structure, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-MS, Biochemical Activity, Reconstituted Complex |
UBA2 |
YDR390C |
Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Aos1p |
physical |
8 |
3 |
6 |
Co-crystal Structure, Biochemical Activity, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Biochemical Activity, Biochemical Activity, Biochemical Activity |
RAD18 |
YCR066W |
E3 ubiquitin ligase |
physical |
7 |
4 |
3 |
Affinity Capture-Western, Two-hybrid, Two-hybrid, Biochemical Activity, Two-hybrid, Reconstituted Complex, Reconstituted Complex |
MMS21 |
YEL019C |
Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex |
physical |
6 |
1 |
6 |
Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex |
POL30 |
YBR088C |
Proliferating cell nuclear antigen (PCNA) |
physical |
5 |
3 |
5 |
Biochemical Activity, Biochemical Activity, Two-hybrid, Affinity Capture-MS, Two-hybrid |
SRS2 |
YJL092W |
DNA helicase and DNA-dependent ATPase |
physical |
4 |
3 |
2 |
Two-hybrid, Biochemical Activity, Reconstituted Complex, Two-hybrid |
AOS1 |
YPR180W |
Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Uba2p |
physical |
3 |
2 |
3 |
Biochemical Activity, Reconstituted Complex, Biochemical Activity |
MOT1 |
YPL082C |
Essential protein involved in regulation of transcription |
genetic |
3 |
2 |
3 |
Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue |
UBC9 |
YDL064W |
SUMO-conjugating enzyme involved in the Smt3p conjugation pathway |
physical |
3 |
2 |
3 |
Two-hybrid, Biochemical Activity, Biochemical Activity |
ULP2 |
YIL031W |
Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins |
genetic |
3 |
2 |
3 |
Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression |
SLX8 |
YER116C |
Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic |
STU2 |
YLR045C |
Microtubule polymerase of the XMAP215/Dis1 family |
physical |
3 |
2 |
2 |
Two-hybrid, Two-hybrid, Biochemical Activity |
RRM3 |
YHR031C |
DNA helicase involved in rDNA replication and Ty1 transposition |
genetic |
3 |
2 |
2 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
KAR9 |
YPL269W |
Spindle positioning factor |
physical |
3 |
2 |
1 |
Two-hybrid, Reconstituted Complex, Reconstituted Complex |
CDC11 |
YJR076C |
Component of the septin ring that is required for cytokinesis |
physical |
2 |
2 |
2 |
Affinity Capture-Western, Affinity Capture-MS |
CDC3 |
YLR314C |
Component of the septin ring that is required for cytokinesis |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Biochemical Activity |
MEC1 |
YBR136W |
Genome integrity checkpoint protein and PI kinase superfamily member |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
RAD52 |
YML032C |
Protein involved in homologous recombination |
physical |
2 |
2 |
2 |
Biochemical Activity, Two-hybrid |
SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Negative Genetic |
TOP1 |
YOL006C |
Topoisomerase I |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Rescue |
NFI1 |
YOR156C |
SUMO E3 ligase |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
EUC1 |
YMR111C |
Sequence-specific DNA binding protein |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Two-hybrid |
NSE5 |
YML023C |
Component of the SMC5-SMC6 complex |
physical |
2 |
1 |
2 |
Two-hybrid, Two-hybrid |
SLX5 |
YDL013W |
Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
physical |
2 |
1 |
2 |
Two-hybrid, Two-hybrid |
MRE11 |
YMR224C |
Nuclease subunit of the MRX complex with Rad50p and Xrs2p |
physical |
2 |
1 |
2 |
Two-hybrid, Two-hybrid |
CBF2 |
YGR140W |
Essential kinetochore protein |
physical |
2 |
1 |
2 |
Two-hybrid, Two-hybrid |
NET1 |
YJL076W |
Core subunit of the RENT complex |
physical |
2 |
2 |
1 |
Affinity Capture-MS, Reconstituted Complex |
MOB2 |
YFL034C-B |
Activator of Cbk1p kinase |
genetic |
2 |
2 |
1 |
Positive Genetic, Negative Genetic |
BIK1 |
YCL029C |
Microtubule-associated protein |
physical |
2 |
2 |
1 |
Two-hybrid, Biochemical Activity |
RAD5 |
YLR032W |
DNA helicase/Ubiquitin ligase |
physical |
2 |
2 |
1 |
Affinity Capture-Western, Two-hybrid |
CST9 |
YLR394W |
SUMO E3 ligase |
physical |
2 |
2 |
1 |
Two-hybrid, Reconstituted Complex |
TOF2 |
YKR010C |
Protein required for rDNA silencing and mitotic rDNA condensation |
physical |
2 |
2 |
1 |
Affinity Capture-MS, Reconstituted Complex |
CKB2 |
YOR039W |
Beta' regulatory subunit of casein kinase 2 (CK2) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
NSE1 |
YLR007W |
Component of the SMC5-SMC6 complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
NSE3 |
YDR288W |
Component of the SMC5-SMC6 complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
NSE5 |
YML023C |
Component of the SMC5-SMC6 complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
RPN11 |
YFR004W |
Metalloprotease subunit of 19S regulatory particle |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
RPT6 |
YGL048C |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
AAR2 |
YBL074C |
Component of the U5 snRNP complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
BRR1 |
YPR057W |
snRNP protein component of spliceosomal snRNPs |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
MUS81 |
YDR386W |
Subunit of structure-specific Mms4p-Mus81p endonuclease |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
MMS4 |
YBR098W |
Subunit of structure-specific Mms4p-Mus81p endonuclease |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
SLX1 |
YBR228W |
Endonuclease involved in DNA recombination and repair |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
UBC4 |
YBR082C |
Ubiquitin-conjugating enzyme (E2) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
MMS22 |
YLR320W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
MCM10 |
YIL150C |
Essential chromatin-associated protein |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
SMT3 |
YDR510W |
Ubiquitin-like protein of the SUMO family |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
ULP1 |
YPL020C |
Protease that specifically cleaves Smt3p protein conjugates |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
VID22 |
YLR373C |
G-quadruplex (G4) DNA binding protein |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
SIZ1 |
YDR409W |
SUMO E3 ligase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
ESC2 |
YDR363W |
Sumo-like domain protein |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
RDS3 |
YPR094W |
Component of the SF3b subcomplex of the U2 snRNP |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
MMS1 |
YPR164W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
RTT109 |
YLL002W |
Histone acetyltransferase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
SLX4 |
YLR135W |
Endonuclease involved in processing DNA |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
IXR1 |
YKL032C |
Transcriptional repressor that regulates hypoxic genes during normoxia |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
YAP6 |
YDR259C |
Basic leucine zipper (bZIP) transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
NUP2 |
YLR335W |
Nucleoporin involved in nucleocytoplasmic transport |
regulation |
1 |
1 |
1 |
in vitro sumoylation assay evidence |
POB3 |
YML069W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
CKB1 |
YGL019W |
Beta regulatory subunit of casein kinase 2 (CK2) |
genetic |
1 |
1 |
1 |
Negative Genetic |
MMS21 |
YEL019C |
Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
ESA1 |
YOR244W |
Catalytic subunit of the histone acetyltransferase complex (NuA4) |
genetic |
1 |
1 |
1 |
Negative Genetic |
DRS1 |
YLL008W |
Nucleolar DEAD-box protein required for ribosome assembly and function |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ERB1 |
YMR049C |
Constituent of 66S pre-ribosomal particles |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HAS1 |
YMR290C |
ATP-dependent RNA helicase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HAS1 |
YMR290C |
ATP-dependent RNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
NIP7 |
YPL211W |
Nucleolar protein required for 60S ribosome subunit biogenesis |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NIP7 |
YPL211W |
Nucleolar protein required for 60S ribosome subunit biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
NOG1 |
YPL093W |
Putative GTPase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NOP2 |
YNL061W |
rRNA m5C methyltransferase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NOP4 |
YPL043W |
Nucleolar protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NOP7 |
YGR103W |
Component of several different pre-ribosomal particles |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NOP7 |
YGR103W |
Component of several different pre-ribosomal particles |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
NSA1 |
YGL111W |
Constituent of 66S pre-ribosomal particles |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
RPF2 |
YKR081C |
Essential protein involved in rRNA maturation and ribosomal assembly |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPL17A |
YKL180W |
Ribosomal 60S subunit protein L17A |
genetic |
1 |
1 |
1 |
Negative Genetic |
RIX7 |
YLL034C |
Putative ATPase of the AAA family |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
PRP46 |
YPL151C |
Member of the NineTeen Complex (NTC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
NTR2 |
YKR022C |
Essential protein that forms a dimer with Ntr1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
KRE29 |
YER038C |
Subunit of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
NOC2 |
YOR206W |
Protein involved in ribosome biogenesis |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NUG1 |
YER006W |
GTPase that associates with nuclear 60S pre-ribosomes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SAP1 |
YER047C |
Putative ATPase of the AAA family |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RRP5 |
YMR229C |
RNA binding protein involved in synthesis of 18S and 5.8S rRNAs |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MTR4 |
YJL050W |
RNA duplex-sensing translocase |
genetic |
1 |
1 |
1 |
Negative Genetic |
TMA64 |
YDR117C |
Protein of unknown function that associates with ribosomes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
LRP1 |
YHR081W |
Nuclear exosome-associated nucleic acid binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPC40 |
YPR110C |
RNA polymerase subunit AC40 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPC37 |
YKR025W |
RNA polymerase III subunit C37 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPA135 |
YPR010C |
RNA polymerase I second largest subunit A135 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ARP9 |
YMR033W |
Component of both the SWI/SNF and RSC chromatin remodeling complexes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PRP40 |
YKL012W |
U1 snRNP protein involved in splicing |
genetic |
1 |
1 |
1 |
Negative Genetic |
SNU56 |
YDR240C |
Component of U1 snRNP required for mRNA splicing via spliceosome |
genetic |
1 |
1 |
1 |
Positive Genetic |
NOP12 |
YOL041C |
Nucleolar protein involved in pre-25S rRNA processing |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPN1 |
YHR027C |
Non-ATPase base subunit of the 19S RP of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPN12 |
YFR052W |
Subunit of the 19S regulatory particle of the 26S proteasome lid |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPN7 |
YPR108W |
Essential non-ATPase regulatory subunit of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPN9 |
YDR427W |
Non-ATPase regulatory subunit of the 26S proteasome |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NIP1 |
YMR309C |
eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPG1 |
YBR079C |
eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RLI1 |
YDR091C |
Essential Fe-S protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
AAH1 |
YNL141W |
Adenine deaminase (adenine aminohydrolase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC39 |
YCR093W |
Subunit of the CCR4-NOT1 core complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
NAM7 |
YMR080C |
ATP-dependent RNA helicase of the SFI superfamily |
physical |
1 |
1 |
1 |
Reconstituted Complex |
TSR2 |
YLR435W |
Protein with a potential role in pre-rRNA processing |
genetic |
1 |
1 |
1 |
Positive Genetic |
AOS1 |
YPR180W |
Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Uba2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
ARD1 |
YHR013C |
Subunit of protein N-terminal acetyltransferase NatA |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ASF1 |
YJL115W |
Nucleosome assembly factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
BEM2 |
YER155C |
Rho GTPase activating protein (RhoGAP) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
BUD20 |
YLR074C |
C2H2-type zinc finger protein required for ribosome assembly |
genetic |
1 |
1 |
1 |
Positive Genetic |
CDC14 |
YFR028C |
Protein phosphatase required for mitotic exit |
physical |
1 |
1 |
1 |
Reconstituted Complex |
CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC10 |
YCR002C |
Component of the septin ring, required for cytokinesis |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CDC12 |
YHR107C |
Component of the septin ring that is required for cytokinesis |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CDC12 |
YHR107C |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
ERG26 |
YGL001C |
C-3 sterol dehydrogenase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
DBP10 |
YDL031W |
Putative ATP-dependent RNA helicase of the DEAD-box protein family |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CKS1 |
YBR135W |
Cyclin-dependent protein kinase regulatory subunit and adaptor |
genetic |
1 |
1 |
1 |
Negative Genetic |
DNA2 |
YHR164C |
ATP-dependent 5'-flap endonuclease and DNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
CIA2 |
YHR122W |
Component of cytosolic iron-sulfur protein assembly (CIA) machinery |
genetic |
1 |
1 |
1 |
Negative Genetic |
FKS1 |
YLR342W |
Catalytic subunit of 1,3-beta-D-glucan synthase |
genetic |
1 |
1 |
1 |
Positive Genetic |
GCN2 |
YDR283C |
Protein kinase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
KRE33 |
YNL132W |
Acetyltransferase required for biogenesis of small ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
KRR1 |
YCL059C |
Nucleolar protein required for rRNA synthesis and ribosomal assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
IMG2 |
YCR071C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
MRM1 |
YOR201C |
Ribose methyltransferase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
BUD3 |
YCL014W |
Guanine nucleotide exchange factor (GEF) for Cdc42p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
KAP114 |
YGL241W |
Karyopherin, responsible for nuclear import of specific proteins |
physical |
1 |
1 |
1 |
Biochemical Activity |
MIS1 |
YBR084W |
Mitochondrial C1-tetrahydrofolate synthase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
FPR4 |
YLR449W |
Peptidyl-prolyl cis-trans isomerase (PPIase) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HMO1 |
YDR174W |
Chromatin associated high mobility group (HMG) family member |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
LPD1 |
YFL018C |
Dihydrolipoamide dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
AAP1 |
YHR047C |
Arginine/alanine amino peptidase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
LEA1 |
YPL213W |
Component of U2 snRNP complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
PRP6 |
YBR055C |
Splicing factor |
physical |
1 |
1 |
1 |
Two-hybrid |
POL2 |
YNL262W |
Catalytic subunit of DNA polymerase (II) epsilon |
genetic |
1 |
1 |
1 |
Negative Genetic |
RAD23 |
YEL037C |
Protein with ubiquitin-like N terminus |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
ILV1 |
YER086W |
Threonine deaminase, catalyzes first step in isoleucine biosynthesis |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RAD51 |
YER095W |
Strand exchange protein |
physical |
1 |
1 |
1 |
Two-hybrid |
RAD51 |
YER095W |
Strand exchange protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
RET2 |
YFR051C |
Delta subunit of the coatomer complex (COPI) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RAD52 |
YML032C |
Protein involved in homologous recombination |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RFC1 |
YOR217W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RFC3 |
YNL290W |
Subunit of heteropentameric Replication factor C (RF-C) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RTS1 |
YOR014W |
B-type regulatory subunit of protein phosphatase 2A (PP2A) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
OPI1 |
YHL020C |
Transcriptional regulator of a variety of genes |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SCS2 |
YER120W |
Integral ER membrane protein, regulates phospholipid metabolism |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SEC63 |
YOR254C |
Essential subunit of Sec63 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SIF2 |
YBR103W |
WD40 repeat-containing subunit of Set3C histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SKI6 |
YGR195W |
Exosome non-catalytic core component |
genetic |
1 |
1 |
1 |
Negative Genetic |
SMD2 |
YLR275W |
Core Sm protein Sm D2 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPT5 |
YOR117W |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
SRO9 |
YCL037C |
Cytoplasmic RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
SRP21 |
YKL122C |
Subunit of the signal recognition particle (SRP) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SSE1 |
YPL106C |
ATPase component of heat shock protein Hsp90 chaperone complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
TAF12 |
YDR145W |
Subunit (61/68 kDa) of TFIID and SAGA complexes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TAF5 |
YBR198C |
Subunit (90 kDa) of TFIID and SAGA complexes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NEW1 |
YPL226W |
Translation termination and ribosome biogenesis factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
TPS1 |
YBR126C |
Synthase subunit of trehalose-6-P synthase/phosphatase complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPT4 |
YOR259C |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
RAD1 |
YPL022W |
Single-stranded DNA endonuclease (with Rad10p) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
HEK2 |
YBL032W |
RNA binding protein involved in asymmetric localization of ASH1 mRNA |
physical |
1 |
1 |
1 |
Biochemical Activity |
ROK1 |
YGL171W |
RNA-dependent ATPase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
LSM12 |
YHR121W |
Protein of unknown function that may function in RNA processing |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
DNM1 |
YLL001W |
Dynamin-related GTPase involved in mitochondrial organization |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ATP4 |
YPL078C |
Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ABP1 |
YCR088W |
Actin-binding protein of the cortical actin cytoskeleton |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CDC5 |
YMR001C |
Polo-like kinase required for mitotic exit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
DCS1 |
YLR270W |
Non-essential hydrolase involved in mRNA decapping |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PMA2 |
YPL036W |
Plasma membrane H+-ATPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
BUD13 |
YGL174W |
Subunit of the RES complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
QCR2 |
YPR191W |
Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) |
genetic |
1 |
1 |
1 |
Negative Genetic |
SLX5 |
YDL013W |
Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex |
physical |
1 |
1 |
1 |
Two-hybrid |
TOP2 |
YNL088W |
Topoisomerase II |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RAD55 |
YDR076W |
Protein that stimulates strand exchange |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
HEF3 |
YNL014W |
Translational elongation factor EF-3 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SEC18 |
YBR080C |
AAA ATPase and SNARE disassembly chaperone |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ILV3 |
YJR016C |
Dihydroxyacid dehydratase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CDC20 |
YGL116W |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Positive Genetic |
KAP122 |
YGL016W |
Karyopherin beta |
genetic |
1 |
1 |
1 |
Negative Genetic |
RNQ1 |
YCL028W |
[PIN(+)] prion |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SFP1 |
YLR403W |
Regulates transcription of ribosomal protein and biogenesis genes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TSL1 |
YML100W |
Large subunit of trehalose 6-phosphate synthase/phosphatase complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RSP5 |
YER125W |
NEDD4 family E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
POL30 |
YBR088C |
Proliferating cell nuclear antigen (PCNA) |
genetic |
1 |
1 |
1 |
Dosage Rescue |
RAD6 |
YGL058W |
Ubiquitin-conjugating enzyme (E2) |
physical |
1 |
1 |
1 |
Two-hybrid |
RAD18 |
YCR066W |
E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
TRR1 |
YDR353W |
Cytoplasmic thioredoxin reductase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TMA19 |
YKL056C |
Protein that associates with ribosomes |
genetic |
1 |
1 |
1 |
Negative Genetic |
SXM1 |
YDR395W |
Nuclear transport factor (karyopherin) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
KEL2 |
YGR238C |
Protein that negatively regulates mitotic exit |
genetic |
1 |
1 |
1 |
Negative Genetic |
KSP1 |
YHR082C |
Serine/threonine protein kinase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
DIA2 |
YOR080W |
Origin-binding F-box protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
MRE11 |
YMR224C |
Nuclease subunit of the MRX complex with Rad50p and Xrs2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
RAD59 |
YDL059C |
Protein involved DNA double-strand break repair |
physical |
1 |
1 |
1 |
Biochemical Activity |
NOP13 |
YNL175C |
Nucleolar protein found in preribosomal complexes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NDE1 |
YMR145C |
Mitochondrial external NADH dehydrogenase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
UBA1 |
YKL210W |
Ubiquitin activating enzyme (E1) |
physical |
1 |
1 |
1 |
Biochemical Activity |
MEC3 |
YLR288C |
DNA damage and meiotic pachytene checkpoint protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
BIR1 |
YJR089W |
Subunit of chromosomal passenger complex (CPC) |
physical |
1 |
1 |
1 |
Two-hybrid |
RED1 |
YLR263W |
Protein component of the synaptonemal complex axial elements |
physical |
1 |
1 |
1 |
Two-hybrid |
SPC24 |
YMR117C |
Component of the kinetochore-associated Ndc80 complex |
physical |
1 |
1 |
1 |
Two-hybrid |
HOF1 |
YMR032W |
F-BAR protein that regulates actin cytoskeleton organization |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
BIM1 |
YER016W |
Microtubule plus end-tracking protein |
physical |
1 |
1 |
1 |
Two-hybrid |
GDS1 |
YOR355W |
Protein involved in histone H4 acetylation at ribosomal protein genes |
genetic |
1 |
1 |
1 |
Negative Genetic |
CWC24 |
YLR323C |
General splicing factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
IRE1 |
YHR079C |
Serine-threonine kinase and endoribonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
NDC80 |
YIL144W |
Component of the kinetochore-associated Ndc80 complex |
physical |
1 |
1 |
1 |
Two-hybrid |
PRP5 |
YBR237W |
RNA helicase in the DEAD-box family |
genetic |
1 |
1 |
1 |
Negative Genetic |
PBY1 |
YBR094W |
Putative tubulin tyrosine ligase associated with P-bodies |
genetic |
1 |
1 |
1 |
Negative Genetic |
SAE2 |
YGL175C |
Endonuclease required for telomere elongation |
genetic |
1 |
1 |
1 |
Negative Genetic |
XRN1 |
YGL173C |
Evolutionarily-conserved 5'-3' exonuclease |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
UTP10 |
YJL109C |
Nucleolar protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
VPS72 |
YDR485C |
Htz1p-binding component of the SWR1 complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
YHR214C-B |
YHR214C-B |
Retrotransposon TYA Gag and TYB Pol genes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
YKT6 |
YKL196C |
Vesicle membrane protein (v-SNARE) with acyltransferase activity |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
YLR419W |
YLR419W |
Putative helicase with limited sequence similarity to human Rb protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
YPK1 |
YKL126W |
S/T protein kinase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
YEN1 |
YER041W |
Holliday junction resolvase |
physical |
1 |
1 |
1 |
Biochemical Activity |
YIA6 |
YIL006W |
Mitochondrial NAD+ transporter |
genetic |
1 |
1 |
1 |
Positive Genetic |
VTI1 |
YMR197C |
Protein involved in cis-Golgi membrane traffic |
genetic |
1 |
1 |
1 |
Negative Genetic |
UFD1 |
YGR048W |
Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase |
genetic |
1 |
1 |
1 |
Negative Genetic |
YMC2 |
YBR104W |
Putative mitochondrial inner membrane transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
WSS1 |
YHR134W |
SUMO-ligase and SUMO-targeted metalloprotease |
genetic |
1 |
1 |
1 |
Negative Genetic |
UPS1 |
YLR193C |
Phosphatidic acid transfer protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
YKE2 |
YLR200W |
Subunit of the heterohexameric Gim/prefoldin protein complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
YML003W |
YML003W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YPR089W |
YPR089W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YKU80 |
YMR106C |
Subunit of telomeric Ku complex (Yku70p-Yku80p) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SWM2 |
YNR004W |
Protein with a role in snRNA and snoRNA cap trimethylation |
genetic |
1 |
1 |
1 |
Negative Genetic |
SMC5 |
YOL034W |
Subunit of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SIW14 |
YNL032W |
Inositol phosphatase involved in inositol pyrophosphate metabolism |
genetic |
1 |
1 |
1 |
Positive Genetic |
CEP3 |
YMR168C |
Essential kinetochore protein |
physical |
1 |
1 |
1 |
Two-hybrid |
RPL9A |
YGL147C |
Ribosomal 60S subunit protein L9A |
genetic |
1 |
1 |
1 |
Negative Genetic |
MCM1 |
YMR043W |
Transcription factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
TSR1 |
YDL060W |
Protein required for processing of 20S pre-rRNA in the cytoplasm |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS1B |
YML063W |
Ribosomal protein of the small (40S) subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
RPL22A |
YLR061W |
Ribosomal 60S subunit protein L22A |
genetic |
1 |
1 |
1 |
Positive Genetic |
BFR1 |
YOR198C |
Component of mRNP complexes associated with polyribosomes |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
CLB5 |
YPR120C |
B-type cyclin involved in DNA replication during S phase |
genetic |
1 |
1 |
1 |
Dosage Lethality |
DBP5 |
YOR046C |
Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PHO80 |
YOL001W |
Cyclin |
genetic |
1 |
1 |
1 |
Positive Genetic |
RAD5 |
YLR032W |
DNA helicase/Ubiquitin ligase |
genetic |
1 |
1 |
1 |
Dosage Lethality |
SEC22 |
YLR268W |
R-SNARE protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
TIF4632 |
YGL049C |
Translation initiation factor eIF4G and scaffold protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ATG2 |
YNL242W |
Peripheral membrane protein required for autophagic vesicle formation |
genetic |
1 |
1 |
1 |
Negative Genetic |
MPT5 |
YGL178W |
mRNA-binding protein of the PUF family |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
POL32 |
YJR043C |
Third subunit of DNA polymerase delta |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
ESC2 |
YDR363W |
Sumo-like domain protein |
physical |
1 |
1 |
1 |
Two-hybrid |
SPC42 |
YKL042W |
Central plaque component of spindle pole body (SPB) |
physical |
1 |
1 |
1 |
Two-hybrid |
NIP100 |
YPL174C |
Large subunit of the dynactin complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
SWC3 |
YAL011W |
Protein of unknown function |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
DID2 |
YKR035W-A |
Class E protein of the vacuolar protein-sorting (Vps) pathway |
genetic |
1 |
1 |
1 |
Negative Genetic |
DBP6 |
YNR038W |
Essential protein involved in ribosome biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
ERV14 |
YGL054C |
COPII-coated vesicle protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
SSB2 |
YNL209W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
1 |
1 |
1 |
Co-purification |
INN1 |
YNL152W |
Essential protein that associates with contractile actomyosin ring |
physical |
1 |
1 |
1 |
PCA |
RRS1 |
YOR294W |
Essential protein that binds ribosomal protein L11 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPL19B |
YBL027W |
Ribosomal 60S subunit protein L19B |
genetic |
1 |
1 |
1 |
Negative Genetic |
SLK19 |
YOR195W |
Kinetochore-associated protein |
physical |
1 |
1 |
1 |
Two-hybrid |
PAC1 |
YOR269W |
Regulator of dynein, involved in intracellular transport |
physical |
1 |
1 |
1 |
Two-hybrid |
CSF1 |
YLR087C |
Protein with structural similarity to lipid transport protein Vps13p |
genetic |
1 |
1 |
1 |
Negative Genetic |
STH1 |
YIL126W |
ATPase component of the RSC chromatin remodeling complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SRS2 |
YJL092W |
DNA helicase and DNA-dependent ATPase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
CST26 |
YBR042C |
Acyltransferase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RMI1 |
YPL024W |
Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
MRH1 |
YDR033W |
Protein that localizes primarily to the plasma membrane |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
1 |
1 |
1 |
Negative Genetic |
COQ10 |
YOL008W |
Coenzyme Q (ubiquinone) binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
FCF2 |
YLR051C |
Nucleolar protein involved in the early steps of 35S rRNA processing |
genetic |
1 |
1 |
1 |
Negative Genetic |
PUF4 |
YGL014W |
Member of the PUF protein family |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
SLF1 |
YDR515W |
RNA binding protein that associates with polysomes |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
SLX8 |
YER116C |
Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex |
physical |
1 |
1 |
1 |
Two-hybrid |
IAI11 |
YBL059W |
Putative mitochondrial protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
SAC1 |
YKL212W |
Phosphatidylinositol phosphate phosphatase |
genetic |
1 |
1 |
1 |
Positive Genetic |
RNH201 |
YNL072W |
Ribonuclease H2 catalytic subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
SMT1 |
YJL147C |
Translational repressor of the mitochondrial ATP6/8 mRNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
TBF1 |
YPL128C |
Telobox-containing general regulatory factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
MDM36 |
YPR083W |
Mitochondrial protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
LEU9 |
YOR108W |
Alpha-isopropylmalate synthase II (2-isopropylmalate synthase) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SRP68 |
YPL243W |
Core component of the signal recognition particle (SRP) complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS10A |
YOR293W |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
PUF2 |
YPR042C |
PUF family mRNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
TYE7 |
YOR344C |
Serine-rich protein that contains a bHLH DNA binding motif |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TOS4 |
YLR183C |
Putative transcription factor, contains Forkhead Associated domain |
genetic |
1 |
1 |
1 |
Negative Genetic |
EOS1 |
YNL080C |
Protein involved in N-glycosylation |
genetic |
1 |
1 |
1 |
Positive Genetic |
SSM4 |
YIL030C |
Membrane-embedded ubiquitin-protein ligase and retrotranslocase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
PNP1 |
YLR209C |
Purine nucleoside phosphorylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
RDL1 |
YOR285W |
Thiosulfate sulfurtransferase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SHE1 |
YBL031W |
Mitotic spindle protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
BIG1 |
YHR101C |
Integral membrane protein of the endoplasmic reticulum |
genetic |
1 |
1 |
1 |
Negative Genetic |
RMR1 |
YGL250W |
Protein required for meiotic recombination and gene conversion |
genetic |
1 |
1 |
1 |
Positive Genetic |
QRI1 |
YDL103C |
UDP-N-acetylglucosamine pyrophosphorylase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
REX4 |
YOL080C |
Putative RNA exonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
TRX3 |
YCR083W |
Mitochondrial thioredoxin |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
LIH1 |
YJR107W |
Putative lipase |
genetic |
1 |
1 |
1 |
Positive Genetic |
HMX1 |
YLR205C |
ER localized heme oxygenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
FLX1 |
YIL134W |
Mitochondrial flavin adenine dinucleotide transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPC3 |
YLR066W |
Subunit of signal peptidase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SND2 |
YLR065C |
Protein involved in SRP-independent targeting of substrates to the ER |
genetic |
1 |
1 |
1 |
Positive Genetic |
MET22 |
YOL064C |
Bisphosphate-3'-nucleotidase |
genetic |
1 |
1 |
1 |
Negative Genetic |
NDI1 |
YML120C |
NADH:ubiquinone oxidoreductase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SRP72 |
YPL210C |
Core component of the signal recognition particle (SRP) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SPP41 |
YDR464W |
Protein of unknown function |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TOP3 |
YLR234W |
DNA Topoisomerase III |
genetic |
1 |
1 |
1 |
Negative Genetic |
RTC6 |
YPL183W-A |
Protein involved in translation |
genetic |
1 |
1 |
1 |
Negative Genetic |
TMA16 |
YOR252W |
Protein of unknown function that associates with ribosomes |
genetic |
1 |
1 |
1 |
Negative Genetic |
APQ12 |
YIL040W |
Nuclear envelope/ER integral membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
TGS1 |
YPL157W |
Trimethyl guanosine synthase, conserved nucleolar methyl transferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MNE1 |
YOR350C |
Protein involved in splicing Group I aI5-beta intron from COX1 mRNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
TMA23 |
YMR269W |
Nucleolar protein implicated in ribosome biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |