Standard name Systematic name Name description Description
GCN2 YDR283C Protein kinase Protein kinase; phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control
Visualize the interactome of GCN2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.953 0.908 0.864
Mito 0.070 0.122 0.352

GFP localization & abundance

GFP localization GFP abundance
cytoplasm 279

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
GCN2 3 0 0 2 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
GCN2 YDR283C Protein kinase physical 11 4 6 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Biochemical Activity, Biochemical Activity, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Reconstituted Complex
GCN1 YGL195W Positive regulator of the Gcn2p kinase activity physical 9 3 5 Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex
GCD7 YLR291C Beta subunit of translation initiation factor eIF2B genetic 7 4 6 Dosage Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Growth Defect, Dosage Rescue, Synthetic Rescue, Synthetic Growth Defect
GCN3 YKR026C Alpha subunit of translation initiation factor eIF2B genetic 6 3 6 Dosage Rescue, Dosage Rescue, Phenotypic Enhancement, Phenotypic Suppression, Dosage Rescue, Dosage Rescue
TEF1 YPR080W Translational elongation factor EF-1 alpha physical 6 3 2 Co-fractionation, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex
GCD2 YGR083C Delta subunit of the translation initiation factor eIF2B genetic 5 3 5 Dosage Rescue, Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue, Dosage Rescue
PPZ1 YML016C Serine/threonine protein phosphatase Z, isoform of Ppz2p genetic 5 2 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Dosage Rescue
SLX9 YGR081C Protein required for pre-rRNA processing genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PHO2 YDL106C Homeobox transcription factor genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BAS1 YKR099W Myb-related transcription factor genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
TEF2 YBR118W Translational elongation factor EF-1 alpha physical 4 3 1 Co-fractionation, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex
PKH1 YDR490C Serine/threonine protein kinase physical 4 3 1 Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Biochemical Activity
GCD11 YER025W Gamma subunit of the translation initiation factor eIF2 genetic 3 3 3 Phenotypic Suppression, Synthetic Rescue, Dosage Rescue
SUI2 YJR007W Alpha subunit of the translation initiation factor eIF2 genetic 3 3 3 Synthetic Growth Defect, Synthetic Rescue, Dosage Rescue
HRR25 YPL204W Conserved casein kinase, monopolin subunit physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
PDB1 YBR221C E1 beta subunit of the pyruvate dehydrogenase (PDH) complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ILV6 YCL009C Regulatory subunit of acetolactate synthase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
MRX19 YDL183C Protein that may form an active mitochondrial KHE system genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
LYS20 YDL182W Homocitrate synthase isozyme and functions in DNA repair genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
INH1 YDL181W Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
LYS21 YDL131W Homocitrate synthase isozyme genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RTG2 YGL252C Sensor of mitochondrial dysfunction genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SNF6 YHL025W Subunit of the SWI/SNF chromatin remodeling complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
HTD2 YHR067W Mitochondrial 3-hydroxyacyl-thioester dehydratase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RPS4B YHR203C Protein component of the small (40S) ribosomal subunit genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
KTI12 YKL110C Protein that plays a role in modification of tRNA wobble nucleosides genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
OAR1 YKL055C Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
LIP2 YLR239C Lipoyl ligase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
MSC1 YML128C Protein of unknown function genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
INP2 YMR163C Peroxisome-specific receptor important for peroxisome inheritance genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
INP1 YMR204C Peripheral membrane protein of peroxisomes genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
YHM2 YMR241W Citrate and oxoglutarate carrier protein genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
MKS1 YNL076W Pleiotropic negative transcriptional regulator genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
LAT1 YNL071W Dihydrolipoamide acetyltransferase component (E2) of the PDC genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
IDH1 YNL037C Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PET8 YNL003C S-adenosylmethionine transporter of the mitochondrial inner membrane genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
NOP12 YOL041C Nucleolar protein involved in pre-25S rRNA processing genetic 3 1 3 Positive Genetic, Positive Genetic, Positive Genetic
LIP5 YOR196C Protein involved in biosynthesis of the coenzyme lipoic acid genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
MCT1 YOR221C Predicted malonyl-CoA:ACP transferase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PUS1 YPL212C tRNA:pseudouridine synthase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
POC4 YPL144W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
AEP2 YMR282C Mitochondrial protein genetic 3 1 3 Positive Genetic, Positive Genetic, Positive Genetic
AIM22 YJL046W Lipoate-protein ligase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ETR1 YBR026C 2-enoyl thioester reductase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CTP1 YBR291C Mitochondrial inner membrane citrate transporter genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ALT1 YLR089C Alanine transaminase (glutamic pyruvic transaminase) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CEM1 YER061C Mitochondrial beta-keto-acyl synthase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
HSP82 YPL240C Hsp90 chaperone physical 3 2 2 Affinity Capture-Western, Affinity Capture-Western, Two-hybrid
KOG1 YHR186C Subunit of TORC1 physical 3 3 1 Affinity Capture-Western, Reconstituted Complex, Biochemical Activity
GCD6 YDR211W Catalytic epsilon subunit of the translation initiation factor eIF2B genetic 2 2 2 Dosage Rescue, Synthetic Rescue
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p genetic 2 2 2 Synthetic Rescue, Phenotypic Suppression
GCN4 YEL009C bZIP transcriptional activator of amino acid biosynthetic genes genetic 2 2 2 Synthetic Rescue, Dosage Rescue
RGC1 YPR115W Putative regulator of the Fps1p glycerol channel physical 2 2 2 Affinity Capture-MS, Reconstituted Complex
RPS22A YJL190C Protein component of the small (40S) ribosomal subunit physical 2 2 2 Reconstituted Complex, Co-fractionation
RPS22B YLR367W Protein component of the small (40S) ribosomal subunit physical 2 2 2 Reconstituted Complex, Co-fractionation
AAR2 YBL074C Component of the U5 snRNP complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PRP31 YGR091W Splicing factor physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PRP4 YPR178W Splicing factor physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PRP6 YBR055C Splicing factor physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SNU114 YKL173W GTPase component of U5 snRNP involved in mRNA splicing via spliceosome physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SNU66 YOR308C Component of the U4/U6.U5 snRNP complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
YGR054W YGR054W Eukaryotic initiation factor eIF2A physical 2 1 2 Biochemical Activity, Biochemical Activity
SUI2 YJR007W Alpha subunit of the translation initiation factor eIF2 physical 2 1 2 Biochemical Activity, Biochemical Activity
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
OCA4 YCR095C Cytoplasmic protein required for replication of Brome mosaic virus genetic 2 1 2 Positive Genetic, Positive Genetic
SIW14 YNL032W Inositol phosphatase involved in inositol pyrophosphate metabolism genetic 2 1 2 Positive Genetic, Positive Genetic
RPS29B YDL061C Protein component of the small (40S) ribosomal subunit genetic 2 1 2 Negative Genetic, Negative Genetic
ZRT1 YGL255W High-affinity zinc transporter of the plasma membrane genetic 2 1 2 Positive Genetic, Positive Genetic
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 2 1 2 Negative Genetic, Negative Genetic
SMM1 YNR015W Dihydrouridine synthase genetic 2 1 2 Negative Genetic, Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 2 1 2 Negative Genetic, Negative Genetic
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain genetic 2 1 2 Negative Genetic, Negative Genetic
NEW1 YPL226W Translation termination and ribosome biogenesis factor genetic 2 1 2 Negative Genetic, Negative Genetic
TGS1 YPL157W Trimethyl guanosine synthase, conserved nucleolar methyl transferase genetic 2 1 2 Negative Genetic, Negative Genetic
MPC1 YGL080W Highly conserved subunit of mitochondrial pyruvate carrier (MPC) genetic 2 1 2 Negative Genetic, Negative Genetic
GCN1 YGL195W Positive regulator of the Gcn2p kinase activity genetic 2 1 2 Dosage Rescue, Dosage Rescue
BUD13 YGL174W Subunit of the RES complex genetic 2 1 2 Negative Genetic, Negative Genetic
GCN20 YFR009W Positive regulator of the Gcn2p kinase activity physical 2 2 1 Affinity Capture-Western, Reconstituted Complex
NPR1 YNL183C Protein kinase physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
TEF1 YPR080W Translational elongation factor EF-1 alpha genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
KRS1 YDR037W Lysyl-tRNA synthetase genetic 2 2 1 Synthetic Rescue, Phenotypic Enhancement
TRP1 YDR007W Phosphoribosylanthranilate isomerase genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SNF1 YDR477W AMP-activated S/T protein kinase regulation 1 1 1 qualitative western immunoblotting evidence
GCN2 YDR283C Protein kinase regulation 1 1 1 protein kinase assay evidence
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
BRR2 YER172C RNA-dependent ATPase RNA helicase (DEIH box) physical 1 1 1 Affinity Capture-MS
FUN12 YAL035W Translation initiation factor eIF5B genetic 1 1 1 Synthetic Growth Defect
DST1 YGL043W General transcription elongation factor TFIIS physical 1 1 1 Reconstituted Complex
GCD1 YOR260W Gamma subunit of the translation initiation factor eIF2B genetic 1 1 1 Dosage Rescue
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) physical 1 1 1 Reconstituted Complex
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 1 1 1 Negative Genetic
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex genetic 1 1 1 Negative Genetic
ERO1 YML130C Thiol oxidase required for oxidative protein folding in the ER genetic 1 1 1 Negative Genetic
UTP21 YLR409C Subunit of U3-containing 90S preribosome and SSU processome complexes physical 1 1 1 Affinity Capture-MS
RRG9 YNL213C Protein of unknown function physical 1 1 1 Affinity Capture-MS
GCN20 YFR009W Positive regulator of the Gcn2p kinase activity genetic 1 1 1 Dosage Rescue
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Growth Defect
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member physical 1 1 1 Affinity Capture-MS
SAS4 YDR181C Subunit of the SAS complex (Sas2p, Sas4p, Sas5p) physical 1 1 1 Affinity Capture-MS
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-MS
HSL1 YKL101W Nim1p-related protein kinase physical 1 1 1 Affinity Capture-MS
SPO75 YLL005C Meiosis-specific protein of unknown function physical 1 1 1 Affinity Capture-MS
STM1 YLR150W Protein required for optimal translation under nutrient stress physical 1 1 1 Affinity Capture-MS
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit physical 1 1 1 Affinity Capture-MS
GFD1 YMR255W Coiled-coiled protein of unknown function physical 1 1 1 Affinity Capture-MS
SLM2 YNL047C Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p physical 1 1 1 Affinity Capture-MS
NHP6A YPR052C High-mobility group (HMG) protein physical 1 1 1 Affinity Capture-MS
PRP8 YHR165C Component of U4/U6-U5 snRNP complex physical 1 1 1 Affinity Capture-MS
NMD5 YJR132W Karyopherin physical 1 1 1 Two-hybrid
POL32 YJR043C Third subunit of DNA polymerase delta physical 1 1 1 Two-hybrid
GCN4 YEL009C bZIP transcriptional activator of amino acid biosynthetic genes physical 1 1 1 Two-hybrid
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SNF1 YDR477W AMP-activated S/T protein kinase physical 1 1 1 Affinity Capture-Western
KIN2 YLR096W S/T protein kinase physical 1 1 1 Affinity Capture-MS
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme physical 1 1 1 Affinity Capture-MS
YMR1 YJR110W Phosphatidylinositol 3-phosphate (PI3P) phosphatase physical 1 1 1 Affinity Capture-MS
MAK10 YEL053C Non-catalytic subunit of the NatC N-terminal acetyltransferase physical 1 1 1 Reconstituted Complex
NOB1 YOR056C Protein involved in proteasomal and 40S ribosomal subunit biogenesis physical 1 1 1 Reconstituted Complex
RDS2 YPL133C Transcription factor involved in regulating gluconeogenesis physical 1 1 1 Reconstituted Complex
RPB5 YBR154C RNA polymerase subunit ABC27 physical 1 1 1 Reconstituted Complex
SKY1 YMR216C SR protein kinase (SRPK) physical 1 1 1 Reconstituted Complex
UBP6 YFR010W Ubiquitin-specific protease physical 1 1 1 Reconstituted Complex
YBL055C YBL055C 3'-->5' exonuclease and endonuclease with a possible role in apoptosis physical 1 1 1 Reconstituted Complex
RPL39 YJL189W Ribosomal 60S subunit protein L39 physical 1 1 1 Reconstituted Complex
SCH9 YHR205W AGC family protein kinase physical 1 1 1 Reconstituted Complex
YIH1 YCR059C Negative regulator of eIF2 kinase Gcn2p physical 1 1 1 Co-fractionation
NFI1 YOR156C SUMO E3 ligase physical 1 1 1 Affinity Capture-MS
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway physical 1 1 1 Affinity Capture-MS
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
TOR1 YJR066W PIK-related protein kinase and rapamycin target physical 1 1 1 Affinity Capture-Western
RPL16A YIL133C Ribosomal 60S subunit protein L16A physical 1 1 1 Affinity Capture-MS
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
VTS1 YOR359W Flap-structured DNA-binding and RNA-binding protein physical 1 1 1 Affinity Capture-RNA
RRP6 YOR001W Nuclear exosome exonuclease component physical 1 1 1 Affinity Capture-MS
PUS4 YNL292W Pseudouridine synthase genetic 1 1 1 Dosage Rescue
NIP1 YMR309C eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3) genetic 1 1 1 Synthetic Lethality
MET22 YOL064C Bisphosphate-3'-nucleotidase genetic 1 1 1 Synthetic Rescue
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
TPS1 YBR126C Synthase subunit of trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Positive Genetic
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Negative Genetic
OCA6 YDR067C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Positive Genetic
SIT4 YDL047W Ceramide-activated, type 2A-related serine-threonine phosphatase genetic 1 1 1 Positive Genetic
KSP1 YHR082C Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
PFK26 YIL107C 6-phosphofructo-2-kinase genetic 1 1 1 Positive Genetic
SAP190 YKR028W Protein that forms a complex with the Sit4p protein phosphatase genetic 1 1 1 Negative Genetic
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 1 1 1 Positive Genetic
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component genetic 1 1 1 Negative Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Negative Genetic
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 1 1 1 Negative Genetic
IST3 YIR005W Component of the U2 snRNP genetic 1 1 1 Negative Genetic
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 1 1 1 Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Positive Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
TOP1 YOL006C Topoisomerase I genetic 1 1 1 Negative Genetic
PSK2 YOL045W PAS-domain containing serine/threonine protein kinase genetic 1 1 1 Negative Genetic
LCB4 YOR171C Sphingoid long-chain base kinase genetic 1 1 1 Positive Genetic
KIN4 YOR233W Serine/threonine protein kinase genetic 1 1 1 Positive Genetic
KAR2 YJL034W ATPase involved in protein import into the ER genetic 1 1 1 Positive Genetic
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Synthetic Growth Defect
OCA1 YNL099C Putative protein tyrosine phosphatase genetic 1 1 1 Positive Genetic
OCA2 YNL056W Protein of unknown function genetic 1 1 1 Positive Genetic
OCA5 YHL029C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Positive Genetic
MYO1 YHR023W Type II myosin heavy chain genetic 1 1 1 Synthetic Growth Defect
TIF5 YPR041W Translation initiation factor eIF5 genetic 1 1 1 Dosage Rescue
RCK1 YGL158W Protein kinase involved in oxidative stress response genetic 1 1 1 Positive Genetic
TOS3 YGL179C Protein kinase genetic 1 1 1 Positive Genetic
MET32 YDR253C Zinc-finger DNA-binding transcription factor genetic 1 1 1 Negative Genetic
VHS1 YDR247W Cytoplasmic serine/threonine protein kinase genetic 1 1 1 Negative Genetic
MSN2 YMR037C Stress-responsive transcriptional activator genetic 1 1 1 Positive Genetic
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Negative Genetic
KAE1 YKR038C Highly conserved ATPase of HSP70/DnaK family genetic 1 1 1 Phenotypic Suppression
PCC1 YKR095W-A Component of the EKC/KEOPS protein complex genetic 1 1 1 Phenotypic Suppression
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation genetic 1 1 1 Phenotypic Suppression
YEF3 YLR249W Translation elongation factor 3 genetic 1 1 1 Dosage Rescue
LEU2 YCL018W Beta-isopropylmalate dehydrogenase (IMDH) genetic 1 1 1 Dosage Rescue
YCT1 YLL055W High-affinity cysteine-specific transporter genetic 1 1 1 Dosage Growth Defect
IRC25 YLR021W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 1 1 1 Negative Genetic
NCS6 YGL211W Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs genetic 1 1 1 Synthetic Rescue
ORC6 YHR118C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Positive Genetic
RPC34 YNR003C RNA polymerase III subunit C34 genetic 1 1 1 Positive Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Negative Genetic
TIM22 YDL217C Essential core component of mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 1 1 1 Negative Genetic
RET2 YFR051C Delta subunit of the coatomer complex (COPI) genetic 1 1 1 Negative Genetic
SMD1 YGR074W Core Sm protein Sm D1 genetic 1 1 1 Negative Genetic
STS1 YIR011C Protein required for localizing proteasomes to the nucleus genetic 1 1 1 Negative Genetic
YJU2 YKL095W Essential protein required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Negative Genetic
RPA190 YOR341W RNA polymerase I largest subunit A190 genetic 1 1 1 Negative Genetic
MOT1 YPL082C Essential protein involved in regulation of transcription genetic 1 1 1 Negative Genetic
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
SLA1 YBL007C Cytoskeletal protein binding protein genetic 1 1 1 Negative Genetic
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Negative Genetic
MSI1 YBR195C Subunit of chromatin assembly factor I (CAF-1) genetic 1 1 1 Negative Genetic
LPD1 YFL018C Dihydrolipoamide dehydrogenase genetic 1 1 1 Negative Genetic
HUR1 YGL168W Protein with a role in DNA repair genetic 1 1 1 Negative Genetic
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 1 1 1 Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Negative Genetic
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 1 1 1 Negative Genetic
TAN1 YGL232W Putative tRNA acetyltransferase genetic 1 1 1 Dosage Rescue
SSD1 YDR293C Translational repressor genetic 1 1 1 Phenotypic Enhancement
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Negative Genetic
GTR1 YML121W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 1 1 1 Phenotypic Suppression
TRM7 YBR061C 2'-O-ribose methyltransferase genetic 1 1 1 Phenotypic Suppression
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
CTI6 YPL181W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 1 1 1 Positive Genetic
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
ATG17 YLR423C Scaffold protein responsible for phagophore assembly site organization genetic 1 1 1 Negative Genetic
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
CMP2 YML057W Calcineurin A physical 1 1 1 Affinity Capture-MS
CMP2 YML057W Calcineurin A genetic 1 1 1 Positive Genetic
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation physical 1 1 1 Affinity Capture-MS
CIK1 YMR198W Kinesin-associated protein genetic 1 1 1 Dosage Growth Defect
FAL1 YDR021W Nucleolar protein required for maturation of 18S rRNA genetic 1 1 1 Negative Genetic
EAP1 YKL204W eIF4E-associated protein, competes with eIF4G for binding to eIF4E genetic 1 1 1 Phenotypic Enhancement
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 1 1 1 Negative Genetic
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Positive Genetic
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 1 1 1 Positive Genetic
BUD27 YFL023W Unconventional prefoldin protein involved in translation initiation genetic 1 1 1 Phenotypic Enhancement
CUP2 YGL166W Copper-binding transcription factor genetic 1 1 1 Positive Genetic
BOS1 YLR078C v-SNARE (vesicle specific SNAP receptor) genetic 1 1 1 Positive Genetic
APC11 YDL008W Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
CST6 YIL036W Basic leucine zipper (bZIP) transcription factor from ATF/CREB family genetic 1 1 1 Negative Genetic
BRE5 YNR051C Ubiquitin protease cofactor physical 1 1 1 Affinity Capture-MS
CLC1 YGR167W Clathrin light chain physical 1 1 1 Affinity Capture-MS
CTK2 YJL006C Beta subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Positive Genetic
GCD10 YNL062C Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p genetic 1 1 1 Phenotypic Suppression
FBP26 YJL155C Fructose-2,6-bisphosphatase, required for glucose metabolism genetic 1 1 1 Positive Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Positive Genetic
GCD14 YJL125C Subunit of tRNA (1-methyladenosine) methyltransferase genetic 1 1 1 Synthetic Rescue
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
CAB1 YDR531W Pantothenate kinase, ATP:D-pantothenate 4'-phosphotransferase genetic 1 1 1 Negative Genetic
EMC4 YGL231C Member of conserved ER transmembrane complex genetic 1 1 1 Dosage Rescue