Standard name Systematic name Name description Description
TOR1 YJR066W PIK-related protein kinase and rapamycin target PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; indole-3-acetic acid, an ATP-competitive inhibitor of TORC1, accumulates upon entry into stationary phase; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
Visualize the interactome of TOR1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data 589

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
TOR1 7 2 0 4 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
KOG1 YHR186C Subunit of TORC1 physical 20 4 16 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-purification, Co-purification, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western
TOR2 YKL203C PIK-related protein kinase and rapamycin target genetic 16 5 14 Phenotypic Enhancement, Dosage Rescue, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement
GTR1 YML121W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 9 4 8 Synthetic Growth Defect, Synthetic Rescue, Negative Genetic, Negative Genetic, Phenotypic Suppression, Synthetic Rescue, Negative Genetic, Negative Genetic, Synthetic Rescue
LST8 YNL006W Protein required for the transport of Gap1p physical 9 3 7 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Co-purification, Affinity Capture-Western, Affinity Capture-MS
PIB2 YGL023C Phosphatidylinositol 3-phosphate binding protein genetic 8 3 7 Negative Genetic, Negative Genetic, Synthetic Rescue, Negative Genetic, Negative Genetic, Dosage Lethality, Synthetic Rescue, Synthetic Rescue
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component genetic 8 1 6 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SCH9 YHR205W AGC family protein kinase genetic 8 4 5 Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Synthetic Rescue, Phenotypic Suppression
TCO89 YPL180W Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p) physical 7 5 6 Affinity Capture-Western, Affinity Capture-MS, Co-purification, Affinity Capture-MS, PCA, Affinity Capture-Western, Biochemical Activity
VAC8 YEL013W Vacuole-specific Myo2p receptor genetic 7 3 6 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Negative Genetic
SLM4 YBR077C Subunit of the EGO/GSE complex genetic 7 4 5 Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
RTG2 YGL252C Sensor of mitochondrial dysfunction genetic 6 3 5 Phenotypic Suppression, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
VAC17 YCL063W Phosphoprotein involved in vacuole inheritance genetic 6 3 5 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Negative Genetic
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p genetic 6 3 5 Synthetic Growth Defect, Synthetic Rescue, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GTR2 YGR163W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 6 3 4 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Rescue, Synthetic Rescue
SLT2 YHR030C Serine/threonine MAP kinase genetic 5 4 5 Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Dosage Rescue, Phenotypic Suppression
SCH9 YHR205W AGC family protein kinase physical 5 1 5 Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity
CCZ1 YBR131W Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 5 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Positive Genetic, Negative Genetic
TCO89 YPL180W Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p) genetic 5 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
LST4 YKL176C Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p genetic 5 2 4 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system physical 5 1 4 Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid
PHO80 YOL001W Cyclin genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PIB2 YGL023C Phosphatidylinositol 3-phosphate binding protein physical 5 3 2 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western
VPS41 YDR080W Subunit of the HOPS endocytic tethering complex genetic 4 2 4 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
YPT7 YML001W Rab family GTPase genetic 4 2 4 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
TPS1 YBR126C Synthase subunit of trehalose-6-P synthase/phosphatase complex genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PEP3 YLR148W Component of CORVET membrane tethering complex genetic 4 3 3 Synthetic Lethality, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Lethality
MTL1 YGR023W Putative plasma membrane sensor genetic 4 3 3 Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Suppression
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
MSH2 YOL090W Protein that binds to DNA mismatches genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
LEA1 YPL213W Component of U2 snRNP complex genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
MEH1 YKR007W Subunit of the EGO/GSE complex genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ELP4 YPL101W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ECM8 YBR076W Non-essential protein of unknown function genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BIK1 YCL029C Microtubule-associated protein physical 4 3 2 Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
SSD1 YDR293C Translational repressor genetic 3 3 3 Dosage Rescue, Synthetic Lethality, Negative Genetic
TAP42 YMR028W Essential protein involved in the TOR signaling pathway physical 3 2 3 Co-purification, Affinity Capture-Western, Affinity Capture-Western
ITC1 YGL133W Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ANP1 YEL036C Subunit of the alpha-1,6 mannosyltransferase complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
YDL180W YDL180W Putative protein of unknown function genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
NGR1 YBR212W RNA binding protein that negatively regulates growth rate genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SAM37 YMR060C Component of the Sorting and Assembly Machinery (SAM) complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
FPR1 YNL135C Peptidyl-prolyl cis-trans isomerase (PPIase) physical 3 2 2 Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
JNM1 YMR294W Component of the yeast dynactin complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SYG1 YIL047C Plasma membrane protein of unknown function genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PET20 YPL159C Mitochondrial protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 2 2 2 Phenotypic Suppression, Negative Genetic
PEP5 YMR231W Histone E3 ligase, component of CORVET membrane tethering complex genetic 2 2 2 Synthetic Lethality, Phenotypic Suppression
SER1 YOR184W 3-phosphoserine aminotransferase genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 2 2 2 Positive Genetic, Phenotypic Enhancement
HOM2 YDR158W Aspartic beta semi-aldehyde dehydrogenase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
LST7 YGR057C Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
GCN4 YEL009C bZIP transcriptional activator of amino acid biosynthetic genes genetic 2 2 2 Phenotypic Suppression, Synthetic Rescue
SWI6 YLR182W Transcription cofactor genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SEC61 YLR378C Conserved ER protein translocation channel physical 2 2 2 Co-fractionation, Affinity Capture-MS
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system genetic 2 2 2 Synthetic Rescue, Phenotypic Suppression
YPK1 YKL126W S/T protein kinase physical 2 2 2 Co-fractionation, Biochemical Activity
VAC7 YNL054W Integral vacuolar membrane protein genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
VPS16 YPL045W Subunit of the HOPS and the CORVET complexes genetic 2 2 2 Synthetic Lethality, Phenotypic Suppression
VAM7 YGL212W Vacuolar SNARE protein genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
VMS1 YDR049W Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
EST2 YLR318W Reverse transcriptase subunit of the telomerase holoenzyme genetic 2 2 2 Dosage Rescue, Synthetic Growth Defect
RPH1 YER169W JmjC domain-containing histone demethylase genetic 2 2 2 Phenotypic Suppression, Synthetic Rescue
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 2 1 2 Negative Genetic, Negative Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 2 1 2 Negative Genetic, Negative Genetic
PAA1 YDR071C Polyamine acetyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
RXT3 YDL076C Component of the Rpd3L histone deacetylase complex genetic 2 1 2 Negative Genetic, Negative Genetic
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 2 1 2 Negative Genetic, Negative Genetic
RIM15 YFL033C Protein kinase involved in cell proliferation in response to nutrients genetic 2 1 2 Phenotypic Suppression, Phenotypic Suppression
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 2 1 2 Negative Genetic, Negative Genetic
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
MPT5 YGL178W mRNA-binding protein of the PUF family physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
FBP1 YLR377C Fructose-1,6-bisphosphatase physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
BUD6 YLR319C Actin- and formin-interacting protein genetic 2 1 2 Negative Genetic, Negative Genetic
YSA1 YBR111C Nudix hydrolase family member with ADP-ribose pyrophosphatase activity genetic 2 1 2 Negative Genetic, Negative Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
RIA1 YNL163C Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis genetic 2 1 2 Negative Genetic, Negative Genetic
COQ2 YNR041C Para hydroxybenzoate polyprenyl transferase genetic 2 1 2 Negative Genetic, Negative Genetic
ISC1 YER019W Inositol phosphosphingolipid phospholipase C genetic 2 1 2 Phenotypic Suppression, Phenotypic Suppression
AGP1 YCL025C Broad-specificity, low-affinity amino acid permease genetic 2 1 2 Positive Genetic, Positive Genetic
AIM25 YJR100C Mitochondria protein of unknown function genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
SIT4 YDL047W Ceramide-activated, type 2A-related serine-threonine phosphatase genetic 2 2 1 Synthetic Rescue, Synthetic Growth Defect
MYO1 YHR023W Type II myosin heavy chain genetic 2 2 1 Phenotypic Enhancement, Synthetic Growth Defect
MDS3 YGL197W Putative component of the TOR regulatory pathway genetic 2 2 1 Phenotypic Enhancement, Synthetic Rescue
SNF1 YDR477W AMP-activated S/T protein kinase genetic 2 2 1 Phenotypic Enhancement, Phenotypic Suppression
MKS1 YNL076W Pleiotropic negative transcriptional regulator physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
KDX1 YKL161C Protein kinase physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
KSP1 YHR082C Serine/threonine protein kinase physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
RAS2 YNL098C GTP-binding protein genetic 2 2 1 Phenotypic Suppression, Phenotypic Enhancement
ICP55 YER078C Mitochondrial aminopeptidase genetic 2 2 1 Synthetic Rescue, Phenotypic Enhancement
FMP48 YGR052W Putative protein of unknown function physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 2 2 1 Phenotypic Suppression, Phenotypic Enhancement
NNK1 YKL171W Protein kinase physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
YPK3 YBR028C AGC kinase physical 2 2 1 Affinity Capture-Western, Biochemical Activity
SKY1 YMR216C SR protein kinase (SRPK) physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
NPR1 YNL183C Protein kinase physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
OMA1 YKR087C Metalloendopeptidase of the mitochondrial inner membrane genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
GCD1 YOR260W Gamma subunit of the translation initiation factor eIF2B genetic 2 1 1 Negative Genetic, Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 1 1 Negative Genetic, Negative Genetic
BNI1 YNL271C Formin genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
LST8 YNL006W Protein required for the transport of Gap1p genetic 2 1 1 Negative Genetic, Negative Genetic
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 2 1 1 Negative Genetic, Negative Genetic
ERG1 YGR175C Squalene epoxidase genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SCH9 YHR205W AGC family protein kinase regulation 1 1 1 qualitative western immunoblotting evidence
YPK3 YBR028C AGC kinase regulation 1 1 1 protein kinase assay evidence
TAT1 YBR069C Amino acid transporter for valine, leucine, isoleucine, and tyrosine regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p regulation 1 1 1 qualitative western immunoblotting evidence
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
BAP2 YBR068C High-affinity leucine permease regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
ATG13 YPR185W Regulatory subunit of the Atg1p signaling complex regulation 1 1 1 qualitative western immunoblotting evidence
DSN1 YIR010W Essential component of the outer kinetochore MIND complex physical 1 1 1 Affinity Capture-MS
TAF14 YPL129W Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes genetic 1 1 1 Synthetic Growth Defect
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex genetic 1 1 1 Synthetic Growth Defect
RVB2 YPL235W ATP-dependent DNA helicase, also known as reptin genetic 1 1 1 Dosage Growth Defect
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Synthetic Growth Defect
MAK16 YAL025C Essential nuclear protein genetic 1 1 1 Negative Genetic
RPF2 YKR081C Essential protein involved in rRNA maturation and ribosomal assembly genetic 1 1 1 Positive Genetic
IPI1 YHR085W Component of the Rix1 complex and possibly pre-replicative complexes genetic 1 1 1 Synthetic Growth Defect
COR1 YBL045C Core subunit of the ubiquinol-cytochrome c reductase complex genetic 1 1 1 Negative Genetic
SMX3 YPR182W Core Sm protein Sm F genetic 1 1 1 Negative Genetic
BMH1 YER177W 14-3-3 protein, major isoform genetic 1 1 1 Synthetic Rescue
SAP185 YJL098W Protein that forms a complex with the Sit4p protein phosphatase physical 1 1 1 Affinity Capture-MS
PAB1 YER165W Poly(A) binding protein physical 1 1 1 Affinity Capture-Western
CDC33 YOL139C Translation initiation factor eIF4E physical 1 1 1 Biochemical Activity
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
RPC25 YKL144C RNA polymerase III subunit C25 genetic 1 1 1 Positive Genetic
RPB4 YJL140W RNA polymerase II subunit B32 genetic 1 1 1 Synthetic Rescue
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p physical 1 1 1 Affinity Capture-MS
MFT1 YML062C Subunit of the THO complex genetic 1 1 1 Synthetic Growth Defect
SUB2 YDL084W Component of the TREX complex required for nuclear mRNA export genetic 1 1 1 Dosage Growth Defect
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome genetic 1 1 1 Synthetic Growth Defect
SRP1 YNL189W Karyopherin alpha homolog physical 1 1 1 Co-localization
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Synthetic Growth Defect
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily physical 1 1 1 Affinity Capture-RNA
PEP1 YBL017C Type I transmembrane sorting receptor for multiple vacuolar hydrolases physical 1 1 1 Co-fractionation
THS1 YIL078W Threonyl-tRNA synthetase genetic 1 1 1 Negative Genetic
ASF1 YJL115W Nucleosome assembly factor genetic 1 1 1 Synthetic Growth Defect
BAT1 YHR208W Mitochondrial branched-chain amino acid (BCAA) aminotransferase genetic 1 1 1 Synthetic Rescue
BEM1 YBR200W Protein containing SH3-domains genetic 1 1 1 Synthetic Growth Defect
BMH2 YDR099W 14-3-3 protein, minor isoform genetic 1 1 1 Synthetic Growth Defect
BEM2 YER155C Rho GTPase activating protein (RhoGAP) physical 1 1 1 Co-fractionation
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 1 1 1 Synthetic Lethality
CDC14 YFR028C Protein phosphatase required for mitotic exit physical 1 1 1 Affinity Capture-MS
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p physical 1 1 1 Co-fractionation
CDC10 YCR002C Component of the septin ring, required for cytokinesis genetic 1 1 1 Synthetic Growth Defect
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) physical 1 1 1 Affinity Capture-MS
COX6 YHR051W Subunit VI of cytochrome c oxidase (Complex IV) genetic 1 1 1 Negative Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 1 1 1 Synthetic Rescue
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Synthetic Growth Defect
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase physical 1 1 1 Co-fractionation
GCN2 YDR283C Protein kinase physical 1 1 1 Affinity Capture-Western
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease genetic 1 1 1 Negative Genetic
HAP2 YGL237C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Synthetic Rescue
BDF2 YDL070W Protein involved in transcription initiation genetic 1 1 1 Negative Genetic
HHF1 YBR009C Histone H4 physical 1 1 1 Affinity Capture-MS
HHF1 YBR009C Histone H4 genetic 1 1 1 Phenotypic Suppression
HHF2 YNL030W Histone H4 physical 1 1 1 Affinity Capture-MS
HSL1 YKL101W Nim1p-related protein kinase genetic 1 1 1 Positive Genetic
KRS1 YDR037W Lysyl-tRNA synthetase genetic 1 1 1 Negative Genetic
LAS17 YOR181W Actin assembly factor physical 1 1 1 Affinity Capture-MS
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Co-localization
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase physical 1 1 1 Biochemical Activity
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
IMG2 YCR071C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
ATG26 YLR189C UDP-glucose:sterol glucosyltransferase genetic 1 1 1 Positive Genetic
MRP20 YDR405W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Synthetic Growth Defect
MRPL7 YDR237W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Synthetic Rescue
MRP51 YPL118W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Synthetic Rescue
GEP3 YOR205C Protein required for mitochondrial ribosome small subunit biogenesis genetic 1 1 1 Positive Genetic
MTR10 YOR160W Nuclear import receptor genetic 1 1 1 Negative Genetic
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos physical 1 1 1 Co-fractionation
MRPL3 YMR024W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Synthetic Rescue
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 1 1 1 Negative Genetic
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member genetic 1 1 1 Synthetic Rescue
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex genetic 1 1 1 Negative Genetic
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 1 1 1 Synthetic Rescue
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Growth Defect
PRO2 YOR323C Gamma-glutamyl phosphate reductase genetic 1 1 1 Negative Genetic
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 1 1 1 Synthetic Growth Defect
PUP3 YER094C Beta 3 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
MAF1 YDR005C Highly conserved negative regulator of RNA polymerase III physical 1 1 1 Biochemical Activity
NUM1 YDR150W Protein required for nuclear migration genetic 1 1 1 Synthetic Growth Defect
RPP2B YDR382W Ribosomal protein P2 beta genetic 1 1 1 Synthetic Growth Defect
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 1 1 1 Synthetic Growth Defect
SGN1 YIR001C Cytoplasmic RNA-binding protein genetic 1 1 1 Negative Genetic
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 1 1 1 Synthetic Rescue
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Positive Genetic
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 1 1 1 Phenotypic Suppression
SLA1 YBL007C Cytoskeletal protein binding protein genetic 1 1 1 Phenotypic Suppression
CCT8 YJL008C Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Co-fractionation
SMD2 YLR275W Core Sm protein Sm D2 genetic 1 1 1 Negative Genetic
PRP11 YDL043C Subunit of the SF3a splicing factor complex genetic 1 1 1 Negative Genetic
NEM1 YHR004C Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme genetic 1 1 1 Synthetic Growth Defect
SPO7 YAL009W Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme genetic 1 1 1 Synthetic Growth Defect
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex genetic 1 1 1 Synthetic Growth Defect
SSL1 YLR005W Subunit of the core form of RNA polymerase transcription factor TFIIH genetic 1 1 1 Negative Genetic
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Synthetic Rescue
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
RRD2 YPL152W Peptidyl-prolyl cis/trans-isomerase genetic 1 1 1 Synthetic Rescue
MKS1 YNL076W Pleiotropic negative transcriptional regulator genetic 1 1 1 Synthetic Growth Defect
SKN1 YGR143W Protein involved in sphingolipid biosynthesis genetic 1 1 1 Positive Genetic
SNF7 YLR025W One of four subunits of the ESCRT-III complex genetic 1 1 1 Synthetic Growth Defect
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
PUF3 YLL013C Protein of the mitochondrial outer surface genetic 1 1 1 Phenotypic Enhancement
GPH1 YPR160W Glycogen phosphorylase required for the mobilization of glycogen genetic 1 1 1 Synthetic Growth Defect
EGD2 YHR193C Alpha subunit of the nascent polypeptide-associated complex (NAC) genetic 1 1 1 Phenotypic Suppression
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly physical 1 1 1 Co-fractionation
MSD1 YPL104W Mitochondrial aspartyl-tRNA synthetase genetic 1 1 1 Synthetic Rescue
GND1 YHR183W 6-phosphogluconate dehydrogenase (decarboxylating) genetic 1 1 1 Negative Genetic
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Positive Genetic
ADO1 YJR105W Adenosine kinase genetic 1 1 1 Negative Genetic
PPQ1 YPL179W Protein phosphatase that regulates the mating response genetic 1 1 1 Synthetic Rescue
TCP1 YDR212W Alpha subunit of chaperonin-containing T-complex genetic 1 1 1 Phenotypic Suppression
ATG29 YPL166W Autophagy-specific protein genetic 1 1 1 Negative Genetic
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
SDH2 YLL041C Iron-sulfur protein subunit of succinate dehydrogenase genetic 1 1 1 Negative Genetic
SAC6 YDR129C Fimbrin, actin-bundling protein physical 1 1 1 Co-fractionation
SAC6 YDR129C Fimbrin, actin-bundling protein genetic 1 1 1 Synthetic Lethality
CDC53 YDL132W Cullin genetic 1 1 1 Negative Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein physical 1 1 1 Co-fractionation
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Synthetic Rescue
PMA1 YGL008C Plasma membrane P2-type H+-ATPase physical 1 1 1 Co-fractionation
KOG1 YHR186C Subunit of TORC1 genetic 1 1 1 Negative Genetic
HXT6 YDR343C High-affinity glucose transporter physical 1 1 1 Co-fractionation
AAT2 YLR027C Cytosolic aspartate aminotransferase involved in nitrogen metabolism genetic 1 1 1 Synthetic Growth Defect
QCR2 YPR191W Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Negative Genetic
PKH2 YOL100W Serine/threonine protein kinase physical 1 1 1 Affinity Capture-Western
HXT7 YDR342C High-affinity glucose transporter physical 1 1 1 Co-fractionation
ATG12 YBR217W Ubiquitin-like modifier involved in autophagy and the Cvt pathway genetic 1 1 1 Negative Genetic
ATG11 YPR049C Adapter protein for pexophagy and the Cvt targeting pathway genetic 1 1 1 Phenotypic Suppression
PET9 YBL030C Major ADP/ATP carrier of the mitochondrial inner membrane genetic 1 1 1 Synthetic Rescue
KRE6 YPR159W Glucosyl hydrolase required for beta-1,6-glucan biosynthesis genetic 1 1 1 Synthetic Growth Defect
SOD2 YHR008C Mitochondrial manganese superoxide dismutase genetic 1 1 1 Dosage Rescue
RHO1 YPR165W GTP-binding protein of the rho subfamily of Ras-like proteins physical 1 1 1 Co-fractionation
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
CAT5 YOR125C Protein required for ubiquinone (Coenzyme Q) biosynthesis genetic 1 1 1 Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Positive Genetic
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes physical 1 1 1 Affinity Capture-Western
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes genetic 1 1 1 Phenotypic Suppression
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
GYP5 YPL249C GTPase-activating protein (GAP) for yeast Rab family members physical 1 1 1 Co-fractionation
MAK11 YKL021C Protein involved in an early step of 60S ribosomal subunit biogenesis genetic 1 1 1 Positive Genetic
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 1 1 1 Negative Genetic
LRO1 YNR008W Acyltransferase that converts diacylglycerol to triacylglycerol (TGA) genetic 1 1 1 Phenotypic Enhancement
GRX1 YCL035C Glutathione-dependent disulfide oxidoreductase genetic 1 1 1 Positive Genetic
MNP1 YGL068W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Dosage Growth Defect
CIN8 YEL061C Bipolar kinesin motor protein genetic 1 1 1 Synthetic Growth Defect
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation genetic 1 1 1 Phenotypic Enhancement
CHS1 YNL192W Chitin synthase I physical 1 1 1 Co-fractionation
ACS1 YAL054C Acetyl-coA synthetase isoform genetic 1 1 1 Positive Genetic
HHT1 YBR010W Histone H3 physical 1 1 1 Affinity Capture-MS
HHT1 YBR010W Histone H3 genetic 1 1 1 Phenotypic Suppression
DIA2 YOR080W Origin-binding F-box protein genetic 1 1 1 Synthetic Growth Defect
CTF4 YPR135W Chromatin-associated protein genetic 1 1 1 Synthetic Growth Defect
SLT2 YHR030C Serine/threonine MAP kinase physical 1 1 1 Co-fractionation
RCK1 YGL158W Protein kinase involved in oxidative stress response physical 1 1 1 Affinity Capture-MS
LHS1 YKL073W Molecular chaperone of the endoplasmic reticulum lumen genetic 1 1 1 Phenotypic Suppression
BEM4 YPL161C Protein involved in establishment of cell polarity and bud emergence genetic 1 1 1 Synthetic Rescue
KSS1 YGR040W Mitogen-activated protein kinase (MAPK) genetic 1 1 1 Phenotypic Enhancement
HOM3 YER052C Aspartate kinase (L-aspartate 4-P-transferase) genetic 1 1 1 Synthetic Growth Defect
ATG20 YDL113C Sorting nexin family member genetic 1 1 1 Positive Genetic
CIK1 YMR198W Kinesin-associated protein genetic 1 1 1 Synthetic Growth Defect
ECM33 YBR078W GPI-anchored protein involved in efficient glucose uptake physical 1 1 1 Co-fractionation
MDH2 YOL126C Cytoplasmic malate dehydrogenase physical 1 1 1 Affinity Capture-Western
HXT5 YHR096C Hexose transporter with moderate affinity for glucose physical 1 1 1 Co-fractionation
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Phenotypic Suppression
CTR1 YPR124W High-affinity copper transporter of plasma membrane physical 1 1 1 Co-fractionation
CTR1 YPR124W High-affinity copper transporter of plasma membrane genetic 1 1 1 Synthetic Rescue
PTC6 YCR079W Mitochondrial type 2C protein phosphatase (PP2C) genetic 1 1 1 Synthetic Growth Defect
RNR1 YER070W Major isoform of large subunit of ribonucleotide-diphosphate reductase genetic 1 1 1 Synthetic Growth Defect
MDH3 YDL078C Peroxisomal malate dehydrogenase genetic 1 1 1 Negative Genetic
QCR7 YDR529C Subunit 7 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Negative Genetic
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains genetic 1 1 1 Synthetic Rescue
SRV2 YNL138W CAP (cyclase-associated protein) physical 1 1 1 Co-fractionation
SRV2 YNL138W CAP (cyclase-associated protein) genetic 1 1 1 Synthetic Lethality
ATP5 YDR298C Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase genetic 1 1 1 Positive Genetic
HOF1 YMR032W F-BAR protein that regulates actin cytoskeleton organization genetic 1 1 1 Synthetic Growth Defect
ADE2 YOR128C Phosphoribosylaminoimidazole carboxylase genetic 1 1 1 Positive Genetic
ATG1 YGL180W Protein serine/threonine kinase genetic 1 1 1 Positive Genetic
ATG13 YPR185W Regulatory subunit of the Atg1p signaling complex physical 1 1 1 Biochemical Activity
DAL82 YNL314W Positive regulator of allophanate inducible genes physical 1 1 1 Two-hybrid
BIM1 YER016W Microtubule plus end-tracking protein physical 1 1 1 Affinity Capture-MS
BNI4 YNL233W Targeting subunit for Glc7p protein phosphatase genetic 1 1 1 Dosage Growth Defect
GTR1 YML121W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex physical 1 1 1 Affinity Capture-Western
GZF3 YJL110C GATA zinc finger protein physical 1 1 1 Two-hybrid
MTF1 YMR228W Mitochondrial RNA polymerase specificity factor physical 1 1 1 Affinity Capture-MS
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Synthetic Growth Defect
SAP4 YGL229C Protein required for function of the Sit4p protein phosphatase physical 1 1 1 Affinity Capture-MS
PPA2 YMR267W Mitochondrial inorganic pyrophosphatase genetic 1 1 1 Positive Genetic
PAL1 YDR348C Protein of unknown function thought to be involved in endocytosis genetic 1 1 1 Synthetic Growth Defect
IRC6 YFR043C Clathrin coat accessory factor genetic 1 1 1 Dosage Growth Defect
KTI12 YKL110C Protein that plays a role in modification of tRNA wobble nucleosides genetic 1 1 1 Synthetic Growth Defect
MDY2 YOL111C Protein involved in inserting tail-anchored proteins into ER membranes genetic 1 1 1 Negative Genetic
PEP12 YOR036W Target membrane receptor (t-SNARE) genetic 1 1 1 Synthetic Growth Defect
COG1 YGL223C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Synthetic Growth Defect
IPL1 YPL209C Aurora kinase of chromosomal passenger complex genetic 1 1 1 Synthetic Rescue
RLP24 YLR009W Essential protein required for ribosomal large subunit biogenesis genetic 1 1 1 Negative Genetic
CRP1 YHR146W Protein that binds to cruciform DNA structures genetic 1 1 1 Synthetic Growth Defect
SAC3 YDR159W mRNA export factor genetic 1 1 1 Synthetic Growth Defect
MSN2 YMR037C Stress-responsive transcriptional activator genetic 1 1 1 Synthetic Rescue
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways physical 1 1 1 Two-hybrid
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways physical 1 1 1 Affinity Capture-MS
RPS11A YDR025W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
CSE4 YKL049C Centromeric histone H3-like protein genetic 1 1 1 Positive Genetic
SSC1 YJR045C Hsp70 family ATPase genetic 1 1 1 Phenotypic Suppression
ELO2 YCR034W Fatty acid elongase, involved in sphingolipid biosynthesis genetic 1 1 1 Negative Genetic
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 1 1 1 Negative Genetic
OST3 YOR085W Gamma subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Positive Genetic
SRO7 YPR032W Effector of Rab GTPase Sec4p physical 1 1 1 Co-fractionation
SRO7 YPR032W Effector of Rab GTPase Sec4p genetic 1 1 1 Synthetic Rescue
STE2 YFL026W Receptor for alpha-factor pheromone physical 1 1 1 Co-fractionation
STP22 YCL008C Component of the ESCRT-I complex genetic 1 1 1 Synthetic Growth Defect
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
SLN1 YIL147C Transmembrane histidine phosphotransfer kinase and osmosensor physical 1 1 1 PCA
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis physical 1 1 1 Co-fractionation
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Synthetic Lethality
CCS1 YMR038C Copper chaperone for superoxide dismutase Sod1p genetic 1 1 1 Synthetic Rescue
ARG82 YDR173C Inositol polyphosphate multikinase (IPMK) genetic 1 1 1 Synthetic Growth Defect
DAL80 YKR034W Negative regulator of genes in multiple nitrogen degradation pathways physical 1 1 1 Two-hybrid
MAC1 YMR021C Copper-sensing transcription factor genetic 1 1 1 Synthetic Rescue
MON1 YGL124C Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
PRP22 YER013W DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
BAT2 YJR148W Cytosolic branched-chain amino acid (BCAA) aminotransferase genetic 1 1 1 Synthetic Rescue
PBP1 YGR178C Component of glucose deprivation induced stress granules physical 1 1 1 Affinity Capture-Western
PBP1 YGR178C Component of glucose deprivation induced stress granules genetic 1 1 1 Dosage Rescue
NIP100 YPL174C Large subunit of the dynactin complex genetic 1 1 1 Synthetic Growth Defect
SRO77 YBL106C Protein with roles in exocytosis and cation homeostasis genetic 1 1 1 Synthetic Rescue
SSO2 YMR183C Plasma membrane t-SNARE physical 1 1 1 Co-fractionation
URE2 YNL229C Nitrogen catabolite repression transcriptional regulator physical 1 1 1 Two-hybrid
URE2 YNL229C Nitrogen catabolite repression transcriptional regulator genetic 1 1 1 Synthetic Growth Defect
TOR2 YKL203C PIK-related protein kinase and rapamycin target physical 1 1 1 Co-purification
UBP6 YFR010W Ubiquitin-specific protease physical 1 1 1 Affinity Capture-MS
VPS54 YDR027C Component of the GARP (Golgi-associated retrograde protein) complex physical 1 1 1 Affinity Capture-MS
UTR2 YEL040W Chitin transglycosylase physical 1 1 1 Co-fractionation
TPO3 YPR156C Polyamine transporter of the major facilitator superfamily physical 1 1 1 Co-fractionation
YOR1 YGR281W Plasma membrane ATP-binding cassette (ABC) transporter physical 1 1 1 Co-fractionation
YOR1 YGR281W Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Negative Genetic
TPD3 YAL016W Regulatory subunit A of the heterotrimeric PP2A complex physical 1 1 1 Co-fractionation
YPK1 YKL126W S/T protein kinase genetic 1 1 1 Synthetic Growth Defect
YLR108C YLR108C Protein of unknown function physical 1 1 1 Affinity Capture-MS
YPT1 YFL038C Rab family GTPase physical 1 1 1 Affinity Capture-Western
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p physical 1 1 1 Biochemical Activity
TSA1 YML028W Thioredoxin peroxidase physical 1 1 1 Affinity Capture-MS
VPS34 YLR240W Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate genetic 1 1 1 Synthetic Growth Defect
VPS15 YBR097W Serine/threonine protein kinase involved in vacuolar protein sorting genetic 1 1 1 Synthetic Growth Defect
VPS33 YLR396C ATP-binding protein that is a subunit of the HOPS and CORVET complexes genetic 1 1 1 Synthetic Lethality
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Synthetic Lethality
TRA1 YHR099W Subunit of SAGA and NuA4 histone acetyltransferase complexes genetic 1 1 1 Synthetic Growth Defect
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Synthetic Growth Defect
VMA11 YPL234C Vacuolar ATPase V0 domain subunit c' genetic 1 1 1 Synthetic Growth Defect
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 1 1 1 Synthetic Growth Defect
UBA4 YHR111W E1-like protein that activates Urm1p before urmylation genetic 1 1 1 Synthetic Growth Defect
UTP9 YHR196W Nucleolar protein genetic 1 1 1 Synthetic Growth Defect
YLR177W YLR177W Putative protein of unknown function genetic 1 1 1 Synthetic Rescue
YHR020W YHR020W Prolyl-tRNA synthetase genetic 1 1 1 Synthetic Growth Defect
UGA2 YBR006W Succinate semialdehyde dehydrogenase genetic 1 1 1 Positive Genetic
YMR1 YJR110W Phosphatidylinositol 3-phosphate (PI3P) phosphatase genetic 1 1 1 Negative Genetic
YPI1 YFR003C Regulatory subunit of the type I protein phosphatase (PP1) Glc7p genetic 1 1 1 Phenotypic Enhancement
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 1 1 1 Phenotypic Enhancement
UPS1 YLR193C Phosphatidic acid transfer protein genetic 1 1 1 Positive Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Positive Genetic
VPS9 YML097C Guanine nucleotide exchange factor (GEF) and ubiquitin receptor genetic 1 1 1 Dosage Rescue
TTI1 YKL033W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
YGR035C YGR035C Putative protein of unknown function, potential Cdc28p substrate genetic 1 1 1 Dosage Growth Defect
TVS1 YCR061W Protein of unknown function genetic 1 1 1 Dosage Growth Defect
UGP1 YKL035W UDP-glucose pyrophosphorylase (UGPase) genetic 1 1 1 Positive Genetic
YIP1 YGR172C Integral membrane protein genetic 1 1 1 Negative Genetic
ZPR1 YGR211W Essential protein with two zinc fingers genetic 1 1 1 Negative Genetic
UMP1 YBR173C Chaperone required for correct maturation of the 20S proteasome genetic 1 1 1 Negative Genetic
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Negative Genetic
VAC14 YLR386W Enzyme regulator genetic 1 1 1 Negative Genetic
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II genetic 1 1 1 Negative Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Growth Defect
GAT1 YFL021W Transcriptional activator of nitrogen catabolite repression genes physical 1 1 1 Two-hybrid
HHT2 YNL031C Histone H3 physical 1 1 1 Affinity Capture-MS
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Synthetic Growth Defect
MSL5 YLR116W Component of commitment complex physical 1 1 1 Two-hybrid
PHB1 YGR132C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 1 1 1 Synthetic Rescue
MIP1 YOR330C Mitochondrial DNA polymerase gamma genetic 1 1 1 Positive Genetic
RPS20 YHL015W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
PAR32 YDL173W Low complexity protein genetic 1 1 1 Synthetic Rescue
ATP17 YDR377W Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase genetic 1 1 1 Positive Genetic
HMG1 YML075C HMG-CoA reductase genetic 1 1 1 Negative Genetic
RPL40B YKR094C Ubiquitin-ribosomal 60S subunit protein L40B fusion protein genetic 1 1 1 Positive Genetic
GAS5 YOL030W 1,3-beta-glucanosyltransferase physical 1 1 1 Co-fractionation
MRH1 YDR033W Protein that localizes primarily to the plasma membrane physical 1 1 1 Co-fractionation
NCE102 YPR149W Protein of unknown function physical 1 1 1 Co-fractionation
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 1 1 1 Positive Genetic
SAT4 YCR008W Ser/Thr protein kinase involved in salt tolerance, nutrient response genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
ICL1 YER065C Isocitrate lyase physical 1 1 1 Affinity Capture-Western
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Synthetic Growth Defect
MTC1 YJL123C Protein of unknown function that may interact with ribosomes genetic 1 1 1 Negative Genetic
RIM8 YGL045W Protein involved in proteolytic activation of Rim101p genetic 1 1 1 Negative Genetic
LCB5 YLR260W Minor sphingoid long-chain base kinase genetic 1 1 1 Negative Genetic
NDT80 YHR124W Meiosis-specific transcription factor genetic 1 1 1 Synthetic Haploinsufficiency
ETR1 YBR026C 2-enoyl thioester reductase genetic 1 1 1 Negative Genetic
GCD14 YJL125C Subunit of tRNA (1-methyladenosine) methyltransferase physical 1 1 1 Affinity Capture-MS
CGI121 YML036W Component of the EKC/KEOPS complex genetic 1 1 1 Phenotypic Enhancement
KIN4 YOR233W Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
GCV3 YAL044C H subunit of the mitochondrial glycine decarboxylase complex genetic 1 1 1 Negative Genetic
NQM1 YGR043C Transaldolase of unknown function genetic 1 1 1 Positive Genetic
PSP2 YML017W Asn rich cytoplasmic protein that contains RGG motifs genetic 1 1 1 Synthetic Rescue
MRPL40 YPL173W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Synthetic Rescue
POC4 YPL144W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 1 1 1 Synthetic Growth Defect
TMA46 YOR091W Protein of unknown function that associates with translating ribosomes physical 1 1 1 Affinity Capture-MS
RDS2 YPL133C Transcription factor involved in regulating gluconeogenesis genetic 1 1 1 Synthetic Haploinsufficiency
IDP3 YNL009W Peroxisomal NADP-dependent isocitrate dehydrogenase genetic 1 1 1 Positive Genetic
STB3 YDR169C Ribosomal RNA processing element (RRPE)-binding protein genetic 1 1 1 Synthetic Rescue
RIM4 YHL024W Putative RNA-binding protein genetic 1 1 1 Negative Genetic
SPE2 YOL052C S-adenosylmethionine decarboxylase genetic 1 1 1 Negative Genetic
GSH1 YJL101C Gamma glutamylcysteine synthetase genetic 1 1 1 Negative Genetic
RPL36A YMR194W Ribosomal 60S subunit protein L36A genetic 1 1 1 Dosage Rescue
RPL26B YGR034W Ribosomal 60S subunit protein L26B genetic 1 1 1 Synthetic Rescue
RPS19B YNL302C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
DGA1 YOR245C Diacylglycerol acyltransferase genetic 1 1 1 Phenotypic Enhancement
MSN4 YKL062W Stress-responsive transcriptional activator genetic 1 1 1 Synthetic Rescue
INP54 YOL065C Phosphatidylinositol 4,5-bisphosphate 5-phosphatase genetic 1 1 1 Positive Genetic
GAS3 YMR215W Putative 1,3-beta-glucanosyltransferase physical 1 1 1 Co-fractionation
SKY1 YMR216C SR protein kinase (SRPK) genetic 1 1 1 Dosage Growth Defect
CHS7 YHR142W Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
PCK1 YKR097W Phosphoenolpyruvate carboxykinase physical 1 1 1 Affinity Capture-Western
CYT1 YOR065W Cytochrome c1 genetic 1 1 1 Negative Genetic
RPS27B YHR021C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
GSC2 YGR032W Catalytic subunit of 1,3-beta-glucan synthase physical 1 1 1 Co-fractionation
DNF2 YDR093W Aminophospholipid translocase (flippase) physical 1 1 1 Co-fractionation
OSH6 YKR003W Oxysterol-binding phosphatidylserine transferase genetic 1 1 1 Phenotypic Suppression
MET7 YOR241W Folylpolyglutamate synthetase genetic 1 1 1 Negative Genetic
HXT2 YMR011W High-affinity glucose transporter of the major facilitator superfamily physical 1 1 1 Co-fractionation
HXT3 YDR345C Low affinity glucose transporter of the major facilitator superfamily physical 1 1 1 Co-fractionation
FRE1 YLR214W Ferric reductase and cupric reductase physical 1 1 1 Co-fractionation
SUR7 YML052W Plasma membrane protein, component of eisosomes physical 1 1 1 Co-fractionation
HXT1 YHR094C Low-affinity glucose transporter of the major facilitator superfamily physical 1 1 1 Co-fractionation
PTR2 YKR093W Integral membrane peptide transporter physical 1 1 1 Co-fractionation
HXT4 YHR092C High-affinity glucose transporter physical 1 1 1 Co-fractionation
SLG1 YOR008C Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway physical 1 1 1 Co-fractionation
SNQ2 YDR011W Plasma membrane ATP-binding cassette (ABC) transporter physical 1 1 1 Co-fractionation
ENA1 YDR040C P-type ATPase sodium pump physical 1 1 1 Co-fractionation
ENA2 YDR039C P-type ATPase sodium pump physical 1 1 1 Co-fractionation
ENA5 YDR038C Protein with similarity to P-type ATPase sodium pumps physical 1 1 1 Co-fractionation
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain physical 1 1 1 Co-fractionation
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain genetic 1 1 1 Synthetic Growth Defect
PHO8 YDR481C Repressible vacuolar alkaline phosphatase physical 1 1 1 Co-fractionation
MUP1 YGR055W High affinity methionine permease genetic 1 1 1 Synthetic Growth Defect
RTC1 YOL138C Subunit of SEACAT, a subcomplex of the SEA complex physical 1 1 1 Affinity Capture-MS
RTC1 YOL138C Subunit of SEACAT, a subcomplex of the SEA complex genetic 1 1 1 Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination physical 1 1 1 Affinity Capture-MS
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Synthetic Growth Defect
COX7 YMR256C Subunit VII of cytochrome c oxidase (Complex IV) genetic 1 1 1 Negative Genetic
CEM1 YER061C Mitochondrial beta-keto-acyl synthase genetic 1 1 1 Negative Genetic
HER2 YMR293C Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex genetic 1 1 1 Positive Genetic
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) genetic 1 1 1 Negative Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Synthetic Growth Defect
SRY1 YKL218C 3-hydroxyaspartate dehydratase genetic 1 1 1 Positive Genetic
ATG41 YPL250C Protein of unknown function genetic 1 1 1 Dosage Growth Defect
COX9 YDL067C Subunit VIIa of cytochrome c oxidase (Complex IV) genetic 1 1 1 Negative Genetic
SUT1 YGL162W Zn(II)2Cys6 family transcription factor genetic 1 1 1 Positive Genetic
IFM1 YOL023W Mitochondrial translation initiation factor 2 genetic 1 1 1 Positive Genetic
APA2 YDR530C Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II genetic 1 1 1 Negative Genetic
NCS6 YGL211W Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs genetic 1 1 1 Synthetic Growth Defect
RPL12B YDR418W Ribosomal 60S subunit protein L12B genetic 1 1 1 Synthetic Growth Defect
TGL3 YMR313C Bifunctional triacylglycerol lipase and LPE acyltransferase genetic 1 1 1 Phenotypic Enhancement
LIP2 YLR239C Lipoyl ligase genetic 1 1 1 Synthetic Growth Defect
MSM1 YGR171C Mitochondrial methionyl-tRNA synthetase (MetRS) genetic 1 1 1 Synthetic Rescue
SRP102 YKL154W Signal recognition particle (SRP) receptor beta subunit genetic 1 1 1 Positive Genetic
SAM3 YPL274W High-affinity S-adenosylmethionine permease genetic 1 1 1 Positive Genetic
OPT2 YPR194C Oligopeptide transporter genetic 1 1 1 Synthetic Growth Defect
TAX4 YJL083W EH domain-containing protein physical 1 1 1 Affinity Capture-MS
SPE1 YKL184W Ornithine decarboxylase genetic 1 1 1 Positive Genetic
MRX19 YDL183C Protein that may form an active mitochondrial KHE system genetic 1 1 1 Dosage Growth Defect
PET100 YDR079W Chaperone that facilitates the assembly of cytochrome c oxidase genetic 1 1 1 Synthetic Rescue
SER2 YGR208W Phosphoserine phosphatase of the phosphoglycerate pathway genetic 1 1 1 Synthetic Growth Defect
MET22 YOL064C Bisphosphate-3'-nucleotidase genetic 1 1 1 Negative Genetic
NDI1 YML120C NADH:ubiquinone oxidoreductase genetic 1 1 1 Positive Genetic
LST4 YKL176C Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p physical 1 1 1 Biochemical Activity
ECM38 YLR299W Gamma-glutamyltranspeptidase genetic 1 1 1 Positive Genetic
SOL3 YHR163W 6-phosphogluconolactonase genetic 1 1 1 Positive Genetic
AAT1 YKL106W Mitochondrial aspartate aminotransferase genetic 1 1 1 Positive Genetic
SHY1 YGR112W Mitochondrial inner membrane protein required for complex IV assembly genetic 1 1 1 Synthetic Rescue
THR4 YCR053W Threonine synthase genetic 1 1 1 Negative Genetic
SPF1 YEL031W P-type ATPase, ion transporter of the ER membrane genetic 1 1 1 Synthetic Rescue
CAX4 YGR036C Dolichyl pyrophosphate (Dol-P-P) phosphatase genetic 1 1 1 Positive Genetic