Standard name Systematic name Name description Description
MDH2 YOL126C Cytoplasmic malate dehydrogenase Cytoplasmic malate dehydrogenase; one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1; mutation in human homolog MDH2 causes early-onset severe encephalopathy
Visualize the interactome of MDH2
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Bud 0.082 0.069 0.109
Budsite 0.101 0.057 0.050
Mito 0.378 0.473 0.162
Peroxisome 0.674 0.551 0.696
SpindlePole 0.345 0.180 0.506
Endosome NaN 0.086 0.067
Nucleolus NaN 0.073 NaN

GFP localization & abundance

GFP localization GFP abundance
peroxisome 5260

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
MDH2 0 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0714 (malate dehydrogenase, cytoplasmic)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 3 1 3 Affinity Capture-RNA, Affinity Capture-RNA, Affinity Capture-RNA
PUF3 YLL013C Protein of the mitochondrial outer surface physical 3 1 3 Affinity Capture-RNA, Affinity Capture-RNA, Affinity Capture-RNA
FKH1 YIL131C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
FKH2 YNL068C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
MDH2 YOL126C Cytoplasmic malate dehydrogenase physical 2 2 2 Two-hybrid, PCA
MDH3 YDL078C Peroxisomal malate dehydrogenase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SKN7 YHR206W Nuclear response regulator and transcription factor regulation 2 1 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence
GET3 YDL100C Guanine nucleotide exchange factor for Gpa1p physical 2 1 2 Two-hybrid, Two-hybrid
MDH1 YKL085W Mitochondrial malate dehydrogenase genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
RPS23A YGR118W Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit genetic 2 1 2 Negative Genetic, Negative Genetic
MSS11 YMR164C Transcription factor genetic 2 1 2 Negative Genetic, Negative Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 2 1 2 Negative Genetic, Negative Genetic
OAR1 YKL055C Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase genetic 2 1 1 Positive Genetic, Positive Genetic
SPE1 YKL184W Ornithine decarboxylase genetic 2 1 1 Positive Genetic, Positive Genetic
MED4 YOR174W Subunit of the RNA polymerase II mediator complex genetic 2 1 1 Negative Genetic, Negative Genetic
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT20 YOL148C Subunit of the SAGA transcriptional regulatory complex regulation 1 1 1 DNA to cDNA expression microarray evidence
STP1 YDR463W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 DNA to cDNA expression microarray evidence
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity regulation 1 1 1 DNA to cDNA expression microarray evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 DNA to cDNA expression microarray evidence
SIP4 YJL089W C6 zinc cluster transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BAS1 YKR099W Myb-related transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
UME6 YDR207C Rpd3L histone deacetylase complex subunit regulation 1 1 1 DNA to cDNA expression microarray evidence
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 DNA to cDNA expression microarray evidence
PPR1 YLR014C Zinc finger transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
WTM1 YOR230W Transcriptional modulator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system regulation 1 1 1 DNA to cDNA expression microarray evidence
PHO2 YDL106C Homeobox transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
CEF1 YMR213W Essential splicing factor genetic 1 1 1 Negative Genetic
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 1 1 1 Negative Genetic
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p genetic 1 1 1 Negative Genetic
ARP7 YPR034W Component of both the SWI/SNF and RSC chromatin remodeling complexes genetic 1 1 1 Negative Genetic
GCD1 YOR260W Gamma subunit of the translation initiation factor eIF2B genetic 1 1 1 Positive Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Positive Genetic
AAR2 YBL074C Component of the U5 snRNP complex genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CCL1 YPR025C Cyclin partner of the cyclin-dependent kinase (CDK) Kin28p genetic 1 1 1 Negative Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Negative Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 1 1 1 Negative Genetic
FIP1 YJR093C Subunit of cleavage polyadenylation factor (CPF) genetic 1 1 1 Positive Genetic
GCD7 YLR291C Beta subunit of translation initiation factor eIF2B genetic 1 1 1 Negative Genetic
KRR1 YCL059C Nucleolar protein required for rRNA synthesis and ribosomal assembly genetic 1 1 1 Positive Genetic
CRM1 YGR218W Nuclear export factor, exportin genetic 1 1 1 Positive Genetic
LSM2 YBL026W Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
DIB1 YPR082C 17-kDa component of the U4/U6aU5 tri-snRNP genetic 1 1 1 Negative Genetic
LST8 YNL006W Protein required for the transport of Gap1p physical 1 1 1 Affinity Capture-Western
LUC7 YDL087C Essential protein associated with the U1 snRNP complex genetic 1 1 1 Negative Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
HRR25 YPL204W Conserved casein kinase, monopolin subunit genetic 1 1 1 Negative Genetic
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-MS
CWC22 YGR278W Spliceosome-associated protein that is required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
DAM1 YGR113W Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
MDH1 YKL085W Mitochondrial malate dehydrogenase physical 1 1 1 Affinity Capture-MS
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Positive Genetic
CDC53 YDL132W Cullin genetic 1 1 1 Positive Genetic
FAA4 YMR246W Long chain fatty acyl-CoA synthetase physical 1 1 1 Affinity Capture-MS
GID7 YCL039W Subunit of GID Complex that binds directly to central component Vid30p physical 1 1 1 Affinity Capture-MS
KOG1 YHR186C Subunit of TORC1 physical 1 1 1 Affinity Capture-Western
MAE1 YKL029C Mitochondrial malic enzyme genetic 1 1 1 Phenotypic Enhancement
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 1 1 1 Negative Genetic
KRI1 YNL308C Essential nucleolar protein required for 40S ribosome biogenesis genetic 1 1 1 Negative Genetic
MET18 YIL128W Component of cytosolic iron-sulfur protein assembly (CIA) machinery physical 1 1 1 Affinity Capture-MS
PDI1 YCL043C Protein disulfide isomerase physical 1 1 1 Affinity Capture-MS
YIL108W YIL108W Putative metalloendopeptidase physical 1 1 1 Affinity Capture-MS
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes physical 1 1 1 Affinity Capture-MS
RFC2 YJR068W Subunit of heteropentameric Replication factor C (RF-C) physical 1 1 1 Affinity Capture-MS
PYK2 YOR347C Pyruvate kinase physical 1 1 1 Two-hybrid
MGA2 YIR033W ER membrane protein involved in regulation of OLE1 transcription physical 1 1 1 Two-hybrid
TCO89 YPL180W Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p) physical 1 1 1 Affinity Capture-Western
TOR1 YJR066W PIK-related protein kinase and rapamycin target physical 1 1 1 Affinity Capture-Western
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-RNA
SSD1 YDR293C Translational repressor physical 1 1 1 Affinity Capture-RNA
SSD1 YDR293C Translational repressor genetic 1 1 1 Negative Genetic
MYO1 YHR023W Type II myosin heavy chain genetic 1 1 1 Dosage Rescue
TMT1 YER175C Trans-aconitate methyltransferase genetic 1 1 1 Positive Genetic
URH1 YDR400W Uridine nucleosidase (uridine-cytidine N-ribohydrolase) genetic 1 1 1 Positive Genetic
PLB2 YMR006C Phospholipase B (lysophospholipase) involved in lipid metabolism genetic 1 1 1 Positive Genetic
PYC2 YBR218C Pyruvate carboxylase isoform genetic 1 1 1 Phenotypic Enhancement
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Rescue
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Positive Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 1 1 1 Positive Genetic
NOP14 YDL148C Nucleolar protein genetic 1 1 1 Positive Genetic
SNM1 YDR478W Ribonuclease MRP complex subunit genetic 1 1 1 Positive Genetic
SKI6 YGR195W Exosome non-catalytic core component genetic 1 1 1 Positive Genetic
SSC1 YJR045C Hsp70 family ATPase genetic 1 1 1 Positive Genetic
SEN1 YLR430W ATP-dependent 5' to 3' RNA/DNA and DNA helicase genetic 1 1 1 Positive Genetic
MEX67 YPL169C Poly(A)RNA binding protein involved in nuclear mRNA export genetic 1 1 1 Positive Genetic
MRPL10 YNL284C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
THR4 YCR053W Threonine synthase genetic 1 1 1 Positive Genetic
REB1 YBR049C RNA polymerase I enhancer binding protein genetic 1 1 1 Negative Genetic
TIM54 YJL054W Component of the mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
MTW1 YAL034W-A Essential component of the MIND kinetochore complex genetic 1 1 1 Negative Genetic
PRP6 YBR055C Splicing factor genetic 1 1 1 Negative Genetic
POP7 YBR167C Subunit of RNase MRP, nuclear RNase P and telomerase genetic 1 1 1 Negative Genetic
MED8 YBR193C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
PRP5 YBR237W RNA helicase in the DEAD-box family genetic 1 1 1 Negative Genetic
PRP9 YDL030W Subunit of the SF3a splicing factor complex genetic 1 1 1 Negative Genetic
PRP11 YDL043C Subunit of the SF3a splicing factor complex genetic 1 1 1 Negative Genetic
SNU23 YDL098C Component of the U4/U6.U5 snRNP complex genetic 1 1 1 Negative Genetic
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 1 1 1 Negative Genetic
RPC11 YDR045C RNA polymerase III subunit C11 genetic 1 1 1 Negative Genetic
SLU7 YDR088C RNA splicing factor genetic 1 1 1 Negative Genetic
SNU56 YDR240C Component of U1 snRNP required for mRNA splicing via spliceosome genetic 1 1 1 Negative Genetic
PRP28 YDR243C Pre-mRNA splicing factor genetic 1 1 1 Negative Genetic
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex genetic 1 1 1 Negative Genetic
SYF1 YDR416W Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
PRP3 YDR473C Splicing factor genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer genetic 1 1 1 Negative Genetic
PRP18 YGR006W Splicing factor and component of snRNP U5 genetic 1 1 1 Negative Genetic
TFC4 YGR047C Subunit of RNA polymerase III transcription initiation factor complex genetic 1 1 1 Negative Genetic
PRP38 YGR075C Unique component of the U4/U6.U5 tri-snRNP particle genetic 1 1 1 Negative Genetic
PRP31 YGR091W Splicing factor genetic 1 1 1 Negative Genetic
OKP1 YGR179C Outer kinetochore protein required for accurate chromosome segregation genetic 1 1 1 Negative Genetic
MED6 YHR058C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RPC17 YJL011C RNA polymerase III subunit C17 genetic 1 1 1 Negative Genetic
PRP21 YJL203W Subunit of the SF3a splicing factor complex genetic 1 1 1 Negative Genetic
MIF2 YKL089W Centromeric CDEIII region binding protein genetic 1 1 1 Negative Genetic
YJU2 YKL095W Essential protein required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
SNU114 YKL173W GTPase component of U5 snRNP involved in mRNA splicing via spliceosome genetic 1 1 1 Negative Genetic
YKT6 YKL196C Vesicle membrane protein (v-SNARE) with acyltransferase activity genetic 1 1 1 Negative Genetic
SSL1 YLR005W Subunit of the core form of RNA polymerase transcription factor TFIIH genetic 1 1 1 Negative Genetic
SED5 YLR026C cis-Golgi t-SNARE syntaxin genetic 1 1 1 Negative Genetic
MSL5 YLR116W Component of commitment complex genetic 1 1 1 Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Negative Genetic
YHC1 YLR298C Component of the U1 snRNP complex required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
TAD3 YLR316C Subunit of tRNA-specific adenosine-34 deaminase genetic 1 1 1 Negative Genetic
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 1 1 1 Negative Genetic
TAF8 YML114C TFIID subunit (65 kDa) genetic 1 1 1 Negative Genetic
VTI1 YMR197C Protein involved in cis-Golgi membrane traffic genetic 1 1 1 Negative Genetic
RNT1 YMR239C Nuclear dsRNA-specific ribonuclease (RNase III) genetic 1 1 1 Negative Genetic
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 1 1 1 Negative Genetic
RPC34 YNR003C RNA polymerase III subunit C34 genetic 1 1 1 Negative Genetic
SEC12 YNR026C Guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
RPO31 YOR116C RNA polymerase III largest subunit C160 genetic 1 1 1 Negative Genetic
RPB2 YOR151C RNA polymerase II second largest subunit B150 genetic 1 1 1 Negative Genetic
TOA1 YOR194C TFIIA large subunit genetic 1 1 1 Negative Genetic
RET3 YPL010W Zeta subunit of the coatomer complex (COPI) genetic 1 1 1 Negative Genetic
NAB3 YPL190C RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) genetic 1 1 1 Negative Genetic
SEC8 YPR055W Essential 121 kDa subunit of the exocyst complex genetic 1 1 1 Negative Genetic
SUA7 YPR086W Transcription factor TFIIB genetic 1 1 1 Negative Genetic
SRP54 YPR088C Signal recognition particle (SRP) subunit (homolog of mammalian SRP54) genetic 1 1 1 Negative Genetic
RDS3 YPR094W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Negative Genetic
PRE2 YPR103W Beta 5 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Negative Genetic
PRP4 YPR178W Splicing factor genetic 1 1 1 Negative Genetic
SEC23 YPR181C GTPase-activating protein, stimulates the GTPase activity of Sar1p genetic 1 1 1 Negative Genetic
REI1 YBR267W Cytoplasmic pre-60S factor genetic 1 1 1 Negative Genetic
SSH1 YBR283C Subunit of the Ssh1 translocon complex genetic 1 1 1 Negative Genetic
SLM3 YDL033C tRNA-specific 2-thiouridylase genetic 1 1 1 Negative Genetic
PUF6 YDR496C Pumilio-homology domain protein genetic 1 1 1 Negative Genetic
YJR084W YJR084W Protein that forms a complex with Thp3p genetic 1 1 1 Negative Genetic
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex genetic 1 1 1 Negative Genetic
MET7 YOR241W Folylpolyglutamate synthetase genetic 1 1 1 Negative Genetic
EXG1 YLR300W Major exo-1,3-beta-glucanase of the cell wall physical 1 1 1 Affinity Capture-MS
CLG1 YGL215W Cyclin-like protein that interacts with Pho85p genetic 1 1 1 Negative Genetic
BNA6 YFR047C Quinolinate phosphoribosyl transferase genetic 1 1 1 Positive Genetic
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 1 1 1 Negative Genetic
BOS1 YLR078C v-SNARE (vesicle specific SNAP receptor) genetic 1 1 1 Negative Genetic
APC11 YDL008W Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Positive Genetic
IPL1 YPL209C Aurora kinase of chromosomal passenger complex genetic 1 1 1 Negative Genetic
CET1 YPL228W RNA 5'-triphosphatase involved in mRNA 5' capping genetic 1 1 1 Negative Genetic
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis genetic 1 1 1 Synthetic Lethality
BET1 YIL004C Type II membrane protein required for vesicular transport genetic 1 1 1 Negative Genetic
HSF1 YGL073W Trimeric heat shock transcription factor genetic 1 1 1 Positive Genetic
FBP1 YLR377C Fructose-1,6-bisphosphatase physical 1 1 1 Reconstituted Complex
FCP1 YMR277W Carboxy-terminal domain (CTD) phosphatase genetic 1 1 1 Negative Genetic
CDC19 YAL038W Pyruvate kinase genetic 1 1 1 Negative Genetic
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Negative Genetic
GTT1 YIR038C ER associated glutathione S-transferase physical 1 1 1 Two-hybrid
ALG1 YBR110W Mannosyltransferase genetic 1 1 1 Negative Genetic
GRE3 YHR104W Aldose reductase genetic 1 1 1 Negative Genetic
FPS1 YLL043W Aquaglyceroporin, plasma membrane channel genetic 1 1 1 Negative Genetic
DGR2 YKL121W Protein of unknown function genetic 1 1 1 Negative Genetic
GPI19 YDR437W Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
KRE9 YJL174W Glycoprotein involved in cell wall beta-glucan assembly genetic 1 1 1 Negative Genetic
GPI14 YJR013W Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I genetic 1 1 1 Negative Genetic
CDC1 YDR182W Putative mannose-ethanolamine phosphate phosphodiesterase genetic 1 1 1 Negative Genetic
GCV1 YDR019C T subunit of the mitochondrial glycine decarboxylase complex genetic 1 1 1 Negative Genetic