Standard name Systematic name Name description Description
GRE3 YHR104W Aldose reductase Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by HOG pathway; overexpression allows xylose fermentation in strains expressing heterologous xylitol dehydrogenase and xylulokinase; protein abundance increases in response to DNA replication stress
Visualize the interactome of GRE3
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
M 146

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.993 1.0 0.944

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 12900

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
GRE3 0 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0688 (L-lactaldehyde:NADP+ 1-oxidoreductase), r_0164 (alcohol dehydrogenase (glycerol, NADP)), r_1093 (xylose reductase), r_0205 (arabinose reductase)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
HSF1 YGL073W Trimeric heat shock transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, DNA to cDNA expression microarray evidence
YPR1 YDR368W NADPH-dependent aldo-keto reductase genetic 2 2 2 Phenotypic Enhancement, Synthetic Growth Defect
GLO1 YML004C Monomeric glyoxalase I genetic 2 2 2 Dosage Rescue, Phenotypic Enhancement
GRE3 YHR104W Aldose reductase physical 2 1 2 PCA, PCA
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PYC2 YBR218C Pyruvate carboxylase isoform genetic 2 1 2 Negative Genetic, Negative Genetic
YBR225W YBR225W Putative protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
RPL41A YDL184C Ribosomal 60S subunit protein L41A genetic 2 1 2 Negative Genetic, Negative Genetic
UGA3 YDL170W Transcriptional activator for GABA-dependent induction of GABA genes genetic 2 1 2 Negative Genetic, Negative Genetic
GDH1 YOR375C NADP(+)-dependent glutamate dehydrogenase genetic 2 2 1 Synthetic Rescue, Synthetic Growth Defect
FET3 YMR058W Ferro-O2-oxidoreductase genetic 2 1 1 Negative Genetic, Negative Genetic
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 2 1 1 Negative Genetic, Negative Genetic
ATG13 YPR185W Regulatory subunit of the Atg1p signaling complex genetic 2 1 1 Positive Genetic, Positive Genetic
ATP18 YML081C-A Subunit of the mitochondrial F1F0 ATP synthase genetic 2 1 1 Negative Genetic, Negative Genetic
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
ROG3 YFR022W Alpha-arrestin involved in ubiquitin-dependent endocytosis genetic 2 1 1 Negative Genetic, Negative Genetic
RPS16A YMR143W Protein component of the small (40S) ribosomal subunit genetic 2 1 1 Negative Genetic, Negative Genetic
MSS11 YMR164C Transcription factor genetic 2 1 1 Positive Genetic, Positive Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 2 1 1 Positive Genetic, Positive Genetic
STI1 YOR027W Evolutionarily-conserved Hsp90 cochaperone genetic 2 1 1 Negative Genetic, Negative Genetic
PET20 YPL159C Mitochondrial protein genetic 2 1 1 Negative Genetic, Negative Genetic
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
MSN2 YMR037C Stress-responsive transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CYC8 YBR112C General transcriptional co-repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MSN4 YKL062W Stress-responsive transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT6 YGR116W Nucleosome remodeling protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CST6 YIL036W Basic leucine zipper (bZIP) transcription factor from ATF/CREB family regulation 1 1 1 DNA to cDNA expression microarray evidence
NCB2 YDR397C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
AMN1 YBR158W Modulator of cell separation and mitotic exit genetic 1 1 1 Negative Genetic
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
BUD14 YAR014C Protein involved in bud-site selection genetic 1 1 1 Positive Genetic
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase genetic 1 1 1 Negative Genetic
BGL2 YGR282C Endo-beta-1,3-glucanase genetic 1 1 1 Negative Genetic
BRR1 YPR057W snRNP protein component of spliceosomal snRNPs genetic 1 1 1 Negative Genetic
CRN1 YLR429W Coronin genetic 1 1 1 Negative Genetic
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis genetic 1 1 1 Negative Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 1 1 1 Dosage Growth Defect
FDO1 YMR144W Protein involved in directionality of mating type switching genetic 1 1 1 Negative Genetic
GPD2 YOL059W NAD-dependent glycerol 3-phosphate dehydrogenase genetic 1 1 1 Dosage Rescue
GPD1 YDL022W NAD-dependent glycerol-3-phosphate dehydrogenase genetic 1 1 1 Dosage Rescue
GAL7 YBR018C Galactose-1-phosphate uridyl transferase genetic 1 1 1 Dosage Rescue
FPK1 YNR047W Ser/Thr protein kinase genetic 1 1 1 Negative Genetic
GID10 YGR066C Recognition component (N-recognin) of the Pro/N-degron pathway genetic 1 1 1 Positive Genetic
ARA1 YBR149W NADP+ dependent arabinose dehydrogenase genetic 1 1 1 Phenotypic Enhancement
GCY1 YOR120W Glycerol dehydrogenase genetic 1 1 1 Phenotypic Enhancement
ADE2 YOR128C Phosphoribosylaminoimidazole carboxylase genetic 1 1 1 Negative Genetic
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 1 1 1 Negative Genetic
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex genetic 1 1 1 Negative Genetic
GAL10 YBR019C UDP-glucose-4-epimerase genetic 1 1 1 Dosage Rescue
GAP1 YKR039W General amino acid permease genetic 1 1 1 Positive Genetic
ARG80 YMR042W Transcription factor involved in regulating arginine-responsive genes genetic 1 1 1 Negative Genetic
ERG5 YMR015C C-22 sterol desaturase genetic 1 1 1 Positive Genetic
EPO1 YMR124W Protein involved in septin-ER tethering genetic 1 1 1 Negative Genetic
ERG2 YMR202W C-8 sterol isomerase genetic 1 1 1 Negative Genetic
FMP32 YFL046W Regulator of mitochondrial proline metabolism genetic 1 1 1 Negative Genetic
ACB1 YGR037C Acyl-CoA-binding protein genetic 1 1 1 Positive Genetic
PCH2 YBR186W Hexameric ring ATPase that remodels chromosome axis protein Hop1p physical 1 1 1 Affinity Capture-MS
PMC1 YGL006W Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions physical 1 1 1 Affinity Capture-MS
YCK2 YNL154C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Biochemical Activity
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPN10 YHR200W Proteasome polyubiquitin receptor physical 1 1 1 Affinity Capture-MS
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
PSK2 YOL045W PAS-domain containing serine/threonine protein kinase physical 1 1 1 Reconstituted Complex
RCK1 YGL158W Protein kinase involved in oxidative stress response physical 1 1 1 Reconstituted Complex
ULP1 YPL020C Protease that specifically cleaves Smt3p protein conjugates physical 1 1 1 PCA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
RRP6 YOR001W Nuclear exosome exonuclease component physical 1 1 1 Affinity Capture-MS
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Growth Defect
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation genetic 1 1 1 Negative Genetic
YBR053C YBR053C Putative protein of unknown function genetic 1 1 1 Negative Genetic
PHO2 YDL106C Homeobox transcription factor genetic 1 1 1 Negative Genetic
YGL262W YGL262W Putative protein of unknown function genetic 1 1 1 Negative Genetic
MDS3 YGL197W Putative component of the TOR regulatory pathway genetic 1 1 1 Negative Genetic
RPL9A YGL147C Ribosomal 60S subunit protein L9A genetic 1 1 1 Negative Genetic
HUL5 YGL141W Multiubiquitin chain assembly factor (E4) genetic 1 1 1 Negative Genetic
PUF4 YGL014W Member of the PUF protein family genetic 1 1 1 Negative Genetic
YGR026W YGR026W Putative protein of unknown function genetic 1 1 1 Negative Genetic
ORM1 YGR038W Protein that mediates sphingolipid homeostasis genetic 1 1 1 Negative Genetic
PDC6 YGR087C Minor isoform of pyruvate decarboxylase genetic 1 1 1 Negative Genetic
YGR153W YGR153W Putative protein of unknown function genetic 1 1 1 Negative Genetic
TIM13 YGR181W Mitochondrial intermembrane space protein genetic 1 1 1 Negative Genetic
RIE1 YGR250C RNA binding protein and negative regulator of START genetic 1 1 1 Negative Genetic
SCW4 YGR279C Cell wall protein with similarity to glucanases genetic 1 1 1 Negative Genetic
RPL6B YLR448W Ribosomal 60S subunit protein L6B genetic 1 1 1 Negative Genetic
HMG2 YLR450W HMG-CoA reductase genetic 1 1 1 Positive Genetic
PHO84 YML123C High-affinity inorganic phosphate (Pi) transporter genetic 1 1 1 Negative Genetic
RAD10 YML095C Single-stranded DNA endonuclease (with Rad1p) genetic 1 1 1 Positive Genetic
TCB3 YML072C Cortical ER protein involved in ER-plasma membrane tethering genetic 1 1 1 Negative Genetic
ITT1 YML068W Protein that modulates the efficiency of translation termination genetic 1 1 1 Negative Genetic
SMA2 YML066C Meiosis-specific prospore membrane protein genetic 1 1 1 Negative Genetic
OGG1 YML060W Nuclear and mitochondrial glycosylase/lyase genetic 1 1 1 Positive Genetic
YML018C YML018C Protein of unknown function genetic 1 1 1 Negative Genetic
PPZ1 YML016C Serine/threonine protein phosphatase Z, isoform of Ppz2p genetic 1 1 1 Positive Genetic
MIX17 YMR002W Mitochondrial intermembrane space protein genetic 1 1 1 Positive Genetic
RCH1 YMR034C Negative regulator of cytosolic calcium homeostasis genetic 1 1 1 Positive Genetic
IMP2 YMR035W Catalytic subunit of mitochondrial inner membrane peptidase complex genetic 1 1 1 Negative Genetic
STB2 YMR053C Protein that interacts with Sin3p in a two-hybrid assay genetic 1 1 1 Negative Genetic
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily genetic 1 1 1 Positive Genetic
HFD1 YMR110C Dehydrogenase involved in ubiquinone and sphingolipid metabolism genetic 1 1 1 Positive Genetic
PKR1 YMR123W V-ATPase assembly factor genetic 1 1 1 Positive Genetic
REC114 YMR133W Protein involved in early stages of meiotic recombination genetic 1 1 1 Negative Genetic
RGM1 YMR182C Putative zinc finger DNA binding transcription factor genetic 1 1 1 Negative Genetic
SOL1 YNR034W Protein with a possible role in tRNA export genetic 1 1 1 Negative Genetic
MNT4 YNR059W Putative alpha-1,3-mannosyltransferase genetic 1 1 1 Negative Genetic
MDH2 YOL126C Cytoplasmic malate dehydrogenase genetic 1 1 1 Negative Genetic
MCH4 YOL119C Protein with similarity to mammalian monocarboxylate permeases genetic 1 1 1 Negative Genetic
ITR2 YOL103W Myo-inositol transporter genetic 1 1 1 Negative Genetic
SDD3 YOL098C Putative metalloprotease genetic 1 1 1 Positive Genetic
GSH2 YOL049W Glutathione synthetase genetic 1 1 1 Negative Genetic
PEX15 YOL044W Tail-anchored type II integral peroxisomal membrane protein genetic 1 1 1 Negative Genetic
YOL029C YOL029C Putative protein of unknown function genetic 1 1 1 Negative Genetic
HRD1 YOL013C Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) genetic 1 1 1 Negative Genetic
MDM12 YOL009C Mitochondrial outer membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
NFI1 YOR156C SUMO E3 ligase genetic 1 1 1 Positive Genetic
YOR186W YOR186W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YOR268C YOR268C Putative protein of unknown function genetic 1 1 1 Negative Genetic
MBF1 YOR298C-A Transcriptional coactivator genetic 1 1 1 Negative Genetic
YPL245W YPL245W Putative protein of unknown function genetic 1 1 1 Negative Genetic
RGL1 YPL066W Regulator of Rho1p signaling, cofactor of Tus1p genetic 1 1 1 Positive Genetic
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 1 1 1 Negative Genetic
SMK1 YPR054W Middle sporulation-specific mitogen-activated protein kinase (MAPK) genetic 1 1 1 Positive Genetic
LTP1 YPR073C Protein phosphotyrosine phosphatase of unknown cellular role genetic 1 1 1 Positive Genetic
YPR114W YPR114W Protein distantly similar to ceramide synthases, Lag1p and Lac1p genetic 1 1 1 Negative Genetic
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 1 1 1 Synthetic Growth Defect
YNK1 YKL067W Nucleoside diphosphate kinase genetic 1 1 1 Negative Genetic
PPT2 YPL148C Phosphopantetheine:protein transferase (PPTase) genetic 1 1 1 Negative Genetic
RBK1 YCR036W Ribokinase, phosphorylates ribose to ribose-5-phosphate genetic 1 1 1 Positive Genetic
QCR7 YDR529C Subunit 7 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Dosage Growth Defect
UBP13 YBL067C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Positive Genetic
IMG1 YCR046C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Negative Genetic
YBL055C YBL055C 3'-->5' exonuclease and endonuclease with a possible role in apoptosis genetic 1 1 1 Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
YBR016W YBR016W Tail-anchored plasma membrane protein with a conserved CYSTM module genetic 1 1 1 Negative Genetic
YDR476C YDR476C Putative protein of unknown function genetic 1 1 1 Negative Genetic
MEI4 YER044C-A Meiosis-specific protein involved in forming DSBs genetic 1 1 1 Negative Genetic
UBP6 YFR010W Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
STE24 YJR117W Highly conserved zinc metalloprotease genetic 1 1 1 Negative Genetic
YRA2 YKL214C Member of the REF (RNA and export factor binding proteins) family genetic 1 1 1 Negative Genetic
IRS4 YKR019C EH domain-containing protein genetic 1 1 1 Negative Genetic
HCR1 YLR192C eIF3j component of translation initiation factor 3 (eIF3) genetic 1 1 1 Negative Genetic
LIP2 YLR239C Lipoyl ligase genetic 1 1 1 Negative Genetic
INA1 YLR413W Protein of unknown function genetic 1 1 1 Negative Genetic
RTC1 YOL138C Subunit of SEACAT, a subcomplex of the SEA complex genetic 1 1 1 Negative Genetic
CMK2 YOL016C Calmodulin-dependent protein kinase physical 1 1 1 Reconstituted Complex
CMR3 YPR013C Putative zinc finger protein genetic 1 1 1 Negative Genetic
DIF1 YLR437C Protein that regulates nuclear import of Rnr2p and Rnr4p genetic 1 1 1 Negative Genetic
ECM7 YLR443W Putative integral membrane protein with a role in calcium uptake genetic 1 1 1 Positive Genetic
CYC1 YJR048W Cytochrome c, isoform 1 genetic 1 1 1 Negative Genetic
ALO1 YML086C D-Arabinono-1,4-lactone oxidase physical 1 1 1 PCA
ARF3 YOR094W Glucose-repressible ADP-ribosylation factor genetic 1 1 1 Negative Genetic
FRE1 YLR214W Ferric reductase and cupric reductase genetic 1 1 1 Negative Genetic
AGA1 YNR044W Anchorage subunit of a-agglutinin of a-cells genetic 1 1 1 Negative Genetic
FSF1 YOR271C Putative protein genetic 1 1 1 Negative Genetic
GPM3 YOL056W Nonfunctional homolog of Gpm1p phosphoglycerate mutase genetic 1 1 1 Negative Genetic
FRE4 YNR060W Ferric reductase genetic 1 1 1 Negative Genetic
APS3 YJL024C Small subunit of the clathrin-associated adaptor complex AP-3 genetic 1 1 1 Negative Genetic
ALD3 YMR169C Cytoplasmic aldehyde dehydrogenase genetic 1 1 1 Negative Genetic
GCV2 YMR189W P subunit of the mitochondrial glycine decarboxylase complex genetic 1 1 1 Negative Genetic
FRE2 YKL220C Ferric reductase and cupric reductase genetic 1 1 1 Negative Genetic
AIM36 YMR157C Protein of unknown function genetic 1 1 1 Negative Genetic