| ORM2 |
YLR350W |
Protein that mediates sphingolipid homeostasis |
genetic |
14 |
3 |
11 |
Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect |
| LCB1 |
YMR296C |
Component of serine palmitoyltransferase |
physical |
6 |
2 |
3 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS |
| SCS7 |
YMR272C |
Sphingolipid alpha-hydroxylase |
genetic |
5 |
2 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Positive Genetic |
| ORM2 |
YLR350W |
Protein that mediates sphingolipid homeostasis |
physical |
4 |
2 |
2 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western |
| MCK1 |
YNL307C |
Dual-specificity ser/thr and tyrosine protein kinase |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| LCB2 |
YDR062W |
Component of serine palmitoyltransferase |
physical |
3 |
2 |
2 |
Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS |
| SAC1 |
YKL212W |
Phosphatidylinositol phosphate phosphatase |
physical |
3 |
2 |
2 |
Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS |
| LCB3 |
YJL134W |
Long-chain base-1-phosphate phosphatase |
genetic |
3 |
2 |
2 |
Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression |
| PMA1 |
YGL008C |
Plasma membrane P2-type H+-ATPase |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| AUR1 |
YKL004W |
Phosphatidylinositol:ceramide phosphoinositol transferase |
genetic |
2 |
2 |
2 |
Dosage Rescue, Synthetic Growth Defect |
| TSC3 |
YBR058C-A |
Protein that stimulates the activity of serine palmitoyltransferase |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Phenotypic Suppression |
| YPK1 |
YKL126W |
S/T protein kinase |
genetic |
2 |
2 |
2 |
Dosage Growth Defect, Phenotypic Suppression |
| DEP1 |
YAL013W |
Component of the Rpd3L histone deacetylase complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| BUD27 |
YFL023W |
Unconventional prefoldin protein involved in translation initiation |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| IRE1 |
YHR079C |
Serine-threonine kinase and endoribonuclease |
genetic |
2 |
1 |
2 |
Phenotypic Suppression, Phenotypic Suppression |
| CET1 |
YPL228W |
RNA 5'-triphosphatase involved in mRNA 5' capping |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| NUP170 |
YBL079W |
Subunit of inner ring of nuclear pore complex (NPC) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| YPK1 |
YKL126W |
S/T protein kinase |
physical |
2 |
1 |
2 |
Biochemical Activity, Biochemical Activity |
| RAD61 |
YDR014W |
Subunit of a complex that inhibits sister chromatid cohesion |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SGF11 |
YPL047W |
Integral subunit of SAGA histone acetyltransferase complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| COX12 |
YLR038C |
Subunit VIb of cytochrome c oxidase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| VMA21 |
YGR105W |
Integral membrane protein required for V-ATPase function |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Phenotypic Enhancement |
| GET1 |
YGL020C |
Subunit of the GET complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| COG7 |
YGL005C |
Component of the conserved oligomeric Golgi complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| NNF2 |
YGR089W |
Protein that exhibits physical and genetic interactions with Rpb8p |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| CWH41 |
YGL027C |
Processing alpha glucosidase I |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| TRS20 |
YBR254C |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| PMT4 |
YJR143C |
Protein O-mannosyltransferase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| ERG4 |
YGL012W |
C-24(28) sterol reductase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| OPI3 |
YJR073C |
Methylene-fatty-acyl-phospholipid synthase |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
| MPO1 |
YGL010W |
Dioxygenase that catalyzes alpha-oxygenation of 2-hydroxy fatty acids |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
ChEC-Seq experiments |
| GCN5 |
YGR252W |
Catalytic subunit of ADA and SAGA histone acetyltransferase complexes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| FKH2 |
YNL068C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
ChEC-Seq experiments |
| GCR1 |
YPL075W |
Transcriptional activator of genes involved in glycolysis |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| MED2 |
YDL005C |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| BUR6 |
YER159C |
Subunit of a heterodimeric NC2 transcription regulator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| CEF1 |
YMR213W |
Essential splicing factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BCP1 |
YDR361C |
Essential nuclear chaperone for ribosomal protein Rpl23p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| LCB2 |
YDR062W |
Component of serine palmitoyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| MED6 |
YHR058C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GIM5 |
YML094W |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NOP14 |
YDL148C |
Nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NEW1 |
YPL226W |
Translation termination and ribosome biogenesis factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CRZ1 |
YNL027W |
Transcription factor, activates transcription of stress response genes |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| HYP2 |
YEL034W |
Translation elongation factor eIF-5A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CNB1 |
YKL190W |
Calcineurin B |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| HSP104 |
YLL026W |
Disaggregase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| CDC20 |
YGL116W |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GPN3 |
YLR243W |
Putative GTPase with a role in biogenesis of RNA pol II and polIII |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EMI2 |
YDR516C |
Hexokinase expressed during growth with low glucose levels |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ECM33 |
YBR078W |
GPI-anchored protein involved in efficient glucose uptake |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MEC3 |
YLR288C |
DNA damage and meiotic pachytene checkpoint protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| HOM2 |
YDR158W |
Aspartic beta semi-aldehyde dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BIR1 |
YJR089W |
Subunit of chromosomal passenger complex (CPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LAC1 |
YKL008C |
Ceramide synthase component |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| NUF2 |
YOL069W |
Component of the kinetochore-associated Ndc80 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GNP1 |
YDR508C |
Broad specificity amino acid permease |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| IPL1 |
YPL209C |
Aurora kinase of chromosomal passenger complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BFR1 |
YOR198C |
Component of mRNP complexes associated with polyribosomes |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| ELO3 |
YLR372W |
Elongase |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| MDM12 |
YOL009C |
Mitochondrial outer membrane protein, ERMES complex subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CST9 |
YLR394W |
SUMO E3 ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FCP1 |
YMR277W |
Carboxy-terminal domain (CTD) phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MID2 |
YLR332W |
O-glycosylated plasma membrane protein |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| GPR1 |
YDL035C |
Plasma membrane G protein coupled receptor (GPCR) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GTT1 |
YIR038C |
ER associated glutathione S-transferase |
physical |
1 |
1 |
1 |
Two-hybrid |
| CCH1 |
YGR217W |
Voltage-gated high-affinity calcium channel |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| CCC1 |
YLR220W |
Vacuolar Fe2+/Mn2+ transporter |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| DIC1 |
YLR348C |
Mitochondrial dicarboxylate carrier |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GRE3 |
YHR104W |
Aldose reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MRPL27 |
YBR282W |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PTK2 |
YJR059W |
Serine/threonine protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SWE1 |
YJL187C |
Protein kinase that regulates the G2/M transition |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SWE1 |
YJL187C |
Protein kinase that regulates the G2/M transition |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| TOS3 |
YGL179C |
Protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| TPK1 |
YJL164C |
cAMP-dependent protein kinase catalytic subunit |
physical |
1 |
1 |
1 |
Biochemical Activity |
| PKP2 |
YGL059W |
Mitochondrial protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| USA1 |
YML029W |
Scaffold subunit of the Hrd1p ubiquitin ligase |
physical |
1 |
1 |
1 |
Two-hybrid |
| SAC1 |
YKL212W |
Phosphatidylinositol phosphate phosphatase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TSC3 |
YBR058C-A |
Protein that stimulates the activity of serine palmitoyltransferase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| ORM1 |
YGR038W |
Protein that mediates sphingolipid homeostasis |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| SSA2 |
YLL024C |
HSP70 family ATP-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SSA1 |
YAL005C |
ATPase involved in protein folding and NLS-directed nuclear transport |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| PAA1 |
YDR071C |
Polyamine acetyltransferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| UME6 |
YDR207C |
Rpd3L histone deacetylase complex subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTF1 |
YGL244W |
Subunit of RNAPII-associated chromatin remodeling Paf1 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PMR1 |
YGL167C |
High affinity Ca2+/Mn2+ P-type ATPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PEX18 |
YHR160C |
Peroxin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD14 |
YMR201C |
Subunit of Nucleotide Excision Repair Factor 1 (NEF1) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RSB1 |
YOR049C |
Sphingoid long-chain base (LCB) efflux transporter |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| SCS2 |
YER120W |
Integral ER membrane protein, regulates phospholipid metabolism |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| SBA1 |
YKL117W |
Co-chaperone that binds and regulates Hsp90 family chaperones |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SUR1 |
YPL057C |
Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SLT2 |
YHR030C |
Serine/threonine MAP kinase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| POL2 |
YNL262W |
Catalytic subunit of DNA polymerase (II) epsilon |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| RVS167 |
YDR388W |
Calmodulin-binding actin-associated protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| VPS1 |
YKR001C |
Dynamin-like GTPase required for vacuolar sorting |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| TOR2 |
YKL203C |
PIK-related protein kinase and rapamycin target |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| YTH1 |
YPR107C |
Essential RNA-binding component of cleavage and polyadenylation factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SGV1 |
YPR161C |
Cyclin (Bur2p)-dependent protein kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SEC31 |
YDL195W |
Component of the Sec13p-Sec31p complex of the COPII vesicle coat |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEC4 |
YFL005W |
Rab family GTPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SSL1 |
YLR005W |
Subunit of the core form of RNA polymerase transcription factor TFIIH |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SMD2 |
YLR275W |
Core Sm protein Sm D2 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAD3 |
YLR316C |
Subunit of tRNA-specific adenosine-34 deaminase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PDS5 |
YMR076C |
Cohesion maintenance factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VTI1 |
YMR197C |
Protein involved in cis-Golgi membrane traffic |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAP1 |
YNL216W |
Essential DNA-binding transcription regulator that binds many loci |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TFB2 |
YPL122C |
Subunit of TFIIH and nucleotide excision repair factor 3 complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRP43 |
YGL120C |
RNA helicase in the DEAH-box family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPC97 |
YHR172W |
Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PAM18 |
YLR008C |
Subunit of the import motor (PAM complex) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SDO1 |
YLR022C |
Guanine nucleotide exchange factor (GEF) for Ria1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TBF1 |
YPL128C |
Telobox-containing general regulatory factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SUS1 |
YBR111W-A |
Global transcriptional regulator, component of SAGA, TREX-2 complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TKL2 |
YBR117C |
Transketolase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPP1B |
YDL130W |
Ribosomal protein P1 beta |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YDL177C |
YDL177C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YAT2 |
YER024W |
Carnitine acetyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VAM6 |
YDL077C |
Guanine nucleotide exchange factor for the GTPase Gtr1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ROF1 |
YHR177W |
Putative transcription factor containing a WOPR domain |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YJR011C |
YJR011C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAV1 |
YJR033C |
Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YLR264C-A |
YLR264C-A |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ROM2 |
YLR371W |
Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RIM9 |
YMR063W |
Plasma membrane protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YMR321C |
YMR321C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VAC7 |
YNL054W |
Integral vacuolar membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YNL108C |
YNL108C |
Protein phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RRG9 |
YNL213C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NPR1 |
YNL183C |
Protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| GPI13 |
YLL031C |
ER membrane localized phosphoryltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ERG3 |
YLR056W |
C-5 sterol desaturase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DPI8 |
YJL133C-A |
Putative mitochondrial protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DGK1 |
YOR311C |
Diacylglycerol kinase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| HXT17 |
YNR072W |
Putative transmembrane polyol transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ATP23 |
YNR020C |
Putative metalloprotease of the mitochondrial inner membrane |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NIT2 |
YJL126W |
Nit protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NRK1 |
YNL129W |
Nicotinamide riboside kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KCH1 |
YJR054W |
Potassium transporter that mediates K+ influx |
genetic |
1 |
1 |
1 |
Negative Genetic |
