Standard name Systematic name Name description Description
NPR1 YNL183C Protein kinase Protein kinase; stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis by phosphorylating Ldb19p; positively regulates activity of the three Mep ammonium transport proteins; mediates inhibitory phosphorylation of Mep2p and Par32p; TOR complex negatively regulates Npr1p activity; NPR1 has a paralog, PRR2, that arose from the whole genome duplication
Visualize the interactome of NPR1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.977 0.996 0.988
Cell Periphery NaN NaN 0.070

GFP localization & abundance

GFP localization GFP abundance
cytoplasm 284

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
NPR1 3 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
PIB2 YGL023C Phosphatidylinositol 3-phosphate binding protein genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Rescue
HAL5 YJL165C Snf1p-related nutrient-responsive protein kinase genetic 3 3 2 Negative Genetic, Dosage Rescue, Phenotypic Suppression
SAT4 YCR008W Ser/Thr protein kinase involved in salt tolerance, nutrient response genetic 3 3 2 Negative Genetic, Dosage Rescue, Phenotypic Suppression
MSI1 YBR195C Subunit of chromatin assembly factor I (CAF-1) physical 3 2 2 Affinity Capture-Western, Two-hybrid, Two-hybrid
GTR2 YGR163W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
GAL83 YER027C One of three alternate beta-subunits of the Snf1 kinase complex physical 2 2 2 Affinity Capture-MS, Reconstituted Complex
PAR32 YDL173W Low complexity protein physical 2 2 2 Affinity Capture-MS, Reconstituted Complex
PAR32 YDL173W Low complexity protein genetic 2 2 2 Synthetic Rescue, Phenotypic Suppression
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 2 2 2 Positive Genetic, Negative Genetic
LEO1 YOR123C Component of the Paf1 complex genetic 2 1 2 Negative Genetic, Negative Genetic
DST1 YGL043W General transcription elongation factor TFIIS genetic 2 1 2 Negative Genetic, Negative Genetic
ARO1 YDR127W Pentafunctional arom protein genetic 2 1 2 Negative Genetic, Negative Genetic
IES1 YFL013C Subunit of the INO80 chromatin remodeling complex genetic 2 1 2 Negative Genetic, Negative Genetic
DIP5 YPL265W Dicarboxylic amino acid permease genetic 2 1 2 Negative Genetic, Negative Genetic
MTC5 YDR128W Subunit of SEACAT, a subcomplex of the SEA complex genetic 2 1 2 Negative Genetic, Negative Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
DIA2 YOR080W Origin-binding F-box protein genetic 2 1 2 Negative Genetic, Negative Genetic
BEM4 YPL161C Protein involved in establishment of cell polarity and bud emergence genetic 2 1 2 Negative Genetic, Negative Genetic
HOM3 YER052C Aspartate kinase (L-aspartate 4-P-transferase) genetic 2 1 2 Negative Genetic, Negative Genetic
HOM2 YDR158W Aspartic beta semi-aldehyde dehydrogenase genetic 2 1 2 Negative Genetic, Negative Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 2 1 2 Negative Genetic, Negative Genetic
ARO2 YGL148W Bifunctional chorismate synthase and flavin reductase genetic 2 1 2 Negative Genetic, Negative Genetic
AGE2 YIL044C ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector genetic 2 1 2 Negative Genetic, Negative Genetic
NPR1 YNL183C Protein kinase physical 2 1 2 Biochemical Activity, Biochemical Activity
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SKY1 YMR216C SR protein kinase (SRPK) genetic 2 1 2 Negative Genetic, Negative Genetic
PPN2 YNL217W Zn2+-dependent endopolyphosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
PEX1 YKL197C AAA-peroxin genetic 2 1 2 Negative Genetic, Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 2 1 2 Negative Genetic, Negative Genetic
SER2 YGR208W Phosphoserine phosphatase of the phosphoglycerate pathway genetic 2 1 2 Negative Genetic, Negative Genetic
PEP1 YBL017C Type I transmembrane sorting receptor for multiple vacuolar hydrolases genetic 2 1 2 Negative Genetic, Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 2 1 2 Negative Genetic, Negative Genetic
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 2 1 2 Negative Genetic, Negative Genetic
RPE1 YJL121C D-ribulose-5-phosphate 3-epimerase genetic 2 1 2 Negative Genetic, Negative Genetic
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
PEX15 YOL044W Tail-anchored type II integral peroxisomal membrane protein genetic 2 1 2 Negative Genetic, Negative Genetic
SAC3 YDR159W mRNA export factor genetic 2 1 2 Negative Genetic, Negative Genetic
STB5 YHR178W Transcription factor genetic 2 1 2 Negative Genetic, Negative Genetic
TKL1 YPR074C Transketolase genetic 2 1 2 Negative Genetic, Negative Genetic
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER genetic 2 1 2 Negative Genetic, Negative Genetic
PEX2 YJL210W RING-finger peroxin and E3 ubiquitin ligase genetic 2 1 2 Negative Genetic, Negative Genetic
SER1 YOR184W 3-phosphoserine aminotransferase genetic 2 1 2 Negative Genetic, Negative Genetic
RTG2 YGL252C Sensor of mitochondrial dysfunction genetic 2 1 2 Positive Genetic, Positive Genetic
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) genetic 2 1 2 Negative Genetic, Negative Genetic
IMP2 YMR035W Catalytic subunit of mitochondrial inner membrane peptidase complex genetic 2 1 2 Negative Genetic, Negative Genetic
LIP2 YLR239C Lipoyl ligase genetic 2 1 2 Negative Genetic, Negative Genetic
MET22 YOL064C Bisphosphate-3'-nucleotidase genetic 2 1 2 Negative Genetic, Negative Genetic
GCN2 YDR283C Protein kinase physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
LDB19 YOR322C Alpha-arrestin, Ub-ligase adaptor for Rsp5p genetic 2 2 1 Synthetic Growth Defect, Phenotypic Suppression
RHO5 YNL180C Non-essential small GTPase of the Rho/Rac family of Ras-like proteins genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
SNF1 YDR477W AMP-activated S/T protein kinase physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
TOR1 YJR066W PIK-related protein kinase and rapamycin target physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
TOR2 YKL203C PIK-related protein kinase and rapamycin target physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SCH9 YHR205W AGC family protein kinase regulation 1 1 1 qualitative western immunoblotting evidence
MEP2 YNL142W Ammonium permease involved in regulation of pseudohyphal growth regulation 1 1 1 qualitative western immunoblotting evidence
TAT2 YOL020W High affinity tryptophan and tyrosine permease regulation 1 1 1 qualitative western immunoblotting evidence
NPR2 YEL062W Subunit of the Iml1p/SEACIT complex regulation 1 1 1 qualitative western immunoblotting evidence
CDC48 YDL126C AAA ATPase with protein-unfoldase activity physical 1 1 1 Reconstituted Complex
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
LST8 YNL006W Protein required for the transport of Gap1p physical 1 1 1 Affinity Capture-MS
MAK10 YEL053C Non-catalytic subunit of the NatC N-terminal acetyltransferase physical 1 1 1 Reconstituted Complex
HRR25 YPL204W Conserved casein kinase, monopolin subunit physical 1 1 1 Affinity Capture-MS
IMG2 YCR071C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
IES5 YER092W Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Negative Genetic
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Negative Genetic
MKS1 YNL076W Pleiotropic negative transcriptional regulator genetic 1 1 1 Synthetic Rescue
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Synthetic Rescue
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Positive Genetic
DPS1 YLL018C Aspartyl-tRNA synthetase, primarily cytoplasmic physical 1 1 1 Reconstituted Complex
KOG1 YHR186C Subunit of TORC1 physical 1 1 1 Affinity Capture-MS
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 1 1 1 Dosage Lethality
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Negative Genetic
KDX1 YKL161C Protein kinase genetic 1 1 1 Negative Genetic
BUL1 YMR275C Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex physical 1 1 1 Affinity Capture-MS
BUL1 YMR275C Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex genetic 1 1 1 Phenotypic Suppression
GIS4 YML006C CAAX box containing protein of unknown function physical 1 1 1 Affinity Capture-MS
KSP1 YHR082C Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
CTF4 YPR135W Chromatin-associated protein physical 1 1 1 Reconstituted Complex
HAP3 YBL021C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Negative Genetic
MEH1 YKR007W Subunit of the EGO/GSE complex genetic 1 1 1 Synthetic Lethality
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Negative Genetic
CLN3 YAL040C G1 cyclin involved in cell cycle progression genetic 1 1 1 Negative Genetic
ENT3 YJR125C Protein containing an N-terminal epsin-like domain genetic 1 1 1 Dosage Growth Defect
BNI4 YNL233W Targeting subunit for Glc7p protein phosphatase genetic 1 1 1 Negative Genetic
LST7 YGR057C Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p genetic 1 1 1 Negative Genetic
ALY2 YJL084C Alpha arrestin, Ub-ligase adaptor for Rsp5p physical 1 1 1 Affinity Capture-Western
AIM18 YHR198C Protein of unknown function genetic 1 1 1 Negative Genetic
CHA4 YLR098C DNA binding transcriptional activator genetic 1 1 1 Negative Genetic
LAM6 YLR072W Sterol transporter that transfers sterols between membranes physical 1 1 1 Affinity Capture-MS
BRE5 YNR051C Ubiquitin protease cofactor genetic 1 1 1 Negative Genetic
ALF1 YNL148C Alpha-tubulin folding protein physical 1 1 1 Reconstituted Complex
CLC1 YGR167W Clathrin light chain physical 1 1 1 Reconstituted Complex
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system genetic 1 1 1 Negative Genetic
ALY1 YKR021W Alpha arrestin, substrate of calcineurin genetic 1 1 1 Dosage Growth Defect
AUR1 YKL004W Phosphatidylinositol:ceramide phosphoinositol transferase genetic 1 1 1 Negative Genetic
HAC1 YFL031W Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) genetic 1 1 1 Negative Genetic
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
MSS4 YDR208W Phosphatidylinositol-4-phosphate 5-kinase genetic 1 1 1 Positive Genetic
BUL2 YML111W Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex genetic 1 1 1 Phenotypic Suppression
HTD2 YHR067W Mitochondrial 3-hydroxyacyl-thioester dehydratase genetic 1 1 1 Negative Genetic
LDB19 YOR322C Alpha-arrestin, Ub-ligase adaptor for Rsp5p physical 1 1 1 Biochemical Activity
DEG1 YFL001W tRNA:pseudouridine synthase genetic 1 1 1 Negative Genetic
SEC7 YDR170C Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors physical 1 1 1 Co-localization
RHO5 YNL180C Non-essential small GTPase of the Rho/Rac family of Ras-like proteins physical 1 1 1 Biochemical Activity
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 1 1 1 Affinity Capture-MS
RSP5 YER125W NEDD4 family E3 ubiquitin ligase physical 1 1 1 Affinity Capture-MS
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex physical 1 1 1 Affinity Capture-MS
SPT2 YER161C Protein involved in negative regulation of transcription physical 1 1 1 Affinity Capture-MS
TCO89 YPL180W Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p) physical 1 1 1 Affinity Capture-MS
TCO89 YPL180W Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p) genetic 1 1 1 Synthetic Rescue
TOR2 YKL203C PIK-related protein kinase and rapamycin target genetic 1 1 1 Dosage Rescue
PIB2 YGL023C Phosphatidylinositol 3-phosphate binding protein physical 1 1 1 Reconstituted Complex
PRS1 YKL181W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase physical 1 1 1 Reconstituted Complex
RIB2 YOL066C Bifunctional DRAP deaminase tRNA:pseudouridine synthase physical 1 1 1 Reconstituted Complex
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Reconstituted Complex
YAR1 YPL239W Nucleocytoplasmic shuttling assembly chaperone physical 1 1 1 Reconstituted Complex
YLR257W YLR257W Protein of unknown function physical 1 1 1 Reconstituted Complex
YPL077C YPL077C Putative protein of unknown function physical 1 1 1 Reconstituted Complex
ORM1 YGR038W Protein that mediates sphingolipid homeostasis physical 1 1 1 Biochemical Activity
ORM2 YLR350W Protein that mediates sphingolipid homeostasis physical 1 1 1 Biochemical Activity
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
SSC1 YJR045C Hsp70 family ATPase physical 1 1 1 Affinity Capture-MS
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
RAS2 YNL098C GTP-binding protein genetic 1 1 1 Synthetic Rescue
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 1 1 1 Dosage Rescue
SIW14 YNL032W Inositol phosphatase involved in inositol pyrophosphate metabolism genetic 1 1 1 Phenotypic Suppression
STE50 YCL032W Adaptor protein for various signaling pathways genetic 1 1 1 Negative Genetic
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Negative Genetic
NRM1 YNR009W Transcriptional co-repressor of MBF-regulated gene expression genetic 1 1 1 Negative Genetic
SLM4 YBR077C Subunit of the EGO/GSE complex genetic 1 1 1 Synthetic Lethality
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Positive Genetic
VPS72 YDR485C Htz1p-binding component of the SWR1 complex genetic 1 1 1 Negative Genetic
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor genetic 1 1 1 Negative Genetic
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 1 1 1 Negative Genetic
TTI1 YKL033W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic
PAU21 YOR394W Protein of unknown function genetic 1 1 1 Dosage Growth Defect
YCT1 YLL055W High-affinity cysteine-specific transporter genetic 1 1 1 Dosage Growth Defect
PGD1 YGL025C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Dosage Growth Defect
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
SOD2 YHR008C Mitochondrial manganese superoxide dismutase genetic 1 1 1 Negative Genetic
SSH1 YBR283C Subunit of the Ssh1 translocon complex genetic 1 1 1 Negative Genetic
UPS1 YLR193C Phosphatidic acid transfer protein genetic 1 1 1 Negative Genetic
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 1 1 1 Positive Genetic
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 1 1 1 Negative Genetic
SLX4 YLR135W Endonuclease involved in processing DNA genetic 1 1 1 Negative Genetic
YPK1 YKL126W S/T protein kinase genetic 1 1 1 Dosage Growth Defect
PER1 YCR044C Protein of the endoplasmic reticulum genetic 1 1 1 Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Negative Genetic
PEX5 YDR244W Peroxisomal membrane signal receptor for peroxisomal matrix proteins genetic 1 1 1 Negative Genetic
PEX10 YDR265W Peroxisomal membrane E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
SWA2 YDR320C Auxilin-like protein involved in vesicular transport genetic 1 1 1 Negative Genetic
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) genetic 1 1 1 Negative Genetic
OST3 YOR085W Gamma subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Positive Genetic
SWI3 YJL176C Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Negative Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Growth Defect
MEP3 YPR138C Ammonium permease of high capacity and low affinity genetic 1 1 1 Dosage Rescue
MEP1 YGR121C Ammonium permease genetic 1 1 1 Dosage Rescue
DYN3 YMR299C Dynein light intermediate chain (LIC) physical 1 1 1 PCA
MEP2 YNL142W Ammonium permease involved in regulation of pseudohyphal growth genetic 1 1 1 Phenotypic Suppression
MIC60 YKR016W Component of the MICOS complex genetic 1 1 1 Negative Genetic
LEE1 YPL054W Zinc-finger protein of unknown function genetic 1 1 1 Dosage Growth Defect
AIM10 YER087W Protein with similarity to tRNA synthetases physical 1 1 1 Reconstituted Complex