SWR1 |
YDR334W |
Swi2/Snf2-related ATPase |
genetic |
11 |
3 |
10 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
ARL1 |
YBR164C |
Soluble GTPase with a role in regulation of membrane traffic |
genetic |
11 |
3 |
9 |
Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Dosage Rescue, Synthetic Lethality, Negative Genetic, Negative Genetic, Dosage Rescue, Negative Genetic, Negative Genetic, Dosage Rescue |
SYS1 |
YJL004C |
Integral membrane protein of the Golgi |
genetic |
11 |
5 |
8 |
Synthetic Lethality, Dosage Rescue, Dosage Rescue, Phenotypic Enhancement, Dosage Rescue, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
GYP1 |
YOR070C |
Cis-golgi GTPase-activating protein (GAP) for yeast Rabs |
genetic |
11 |
3 |
7 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
ARL3 |
YPL051W |
ARF-like small GTPase of the RAS superfamily |
genetic |
10 |
3 |
7 |
Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
HTZ1 |
YOL012C |
Histone variant H2AZ |
genetic |
9 |
3 |
8 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
VPS71 |
YML041C |
Nucleosome-binding component of the SWR1 complex |
genetic |
9 |
2 |
8 |
Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
LSM1 |
YJL124C |
Lsm (Like Sm) protein |
genetic |
9 |
1 |
8 |
Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic |
GET1 |
YGL020C |
Subunit of the GET complex |
genetic |
9 |
3 |
7 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
VPS35 |
YJL154C |
Endosomal subunit of membrane-associated retromer complex |
genetic |
9 |
3 |
7 |
Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
RIC1 |
YLR039C |
Protein involved in retrograde transport to the cis-Golgi network |
genetic |
8 |
2 |
7 |
Dosage Rescue, Dosage Rescue, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic |
SNF4 |
YGL115W |
Activating gamma subunit of the AMP-activated Snf1p kinase complex |
genetic |
8 |
2 |
7 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
VPS29 |
YHR012W |
Subunit of the membrane-associated retromer complex |
genetic |
8 |
3 |
6 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
TLG2 |
YOL018C |
Syntaxin-like t-SNARE |
genetic |
8 |
3 |
6 |
Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
VPS17 |
YOR132W |
Subunit of the membrane-associated retromer complex |
genetic |
8 |
3 |
6 |
Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
VPS30 |
YPL120W |
Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II |
genetic |
8 |
2 |
6 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
IMH1 |
YLR309C |
Protein involved in vesicular transport |
genetic |
7 |
4 |
6 |
Synthetic Lethality, Dosage Rescue, Synthetic Growth Defect, Dosage Rescue, Dosage Rescue, Phenotypic Enhancement, Dosage Rescue |
GDI1 |
YER136W |
GDP dissociation inhibitor |
physical |
7 |
3 |
6 |
Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Affinity Capture-MS, PCA, Two-hybrid, Affinity Capture-MS |
RUD3 |
YOR216C |
Golgi matrix protein |
genetic |
7 |
3 |
6 |
Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
LEO1 |
YOR123C |
Component of the Paf1 complex |
genetic |
7 |
2 |
6 |
Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
TRS85 |
YDR108W |
Component of transport protein particle (TRAPP) complex III |
genetic |
7 |
2 |
6 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
BRE5 |
YNR051C |
Ubiquitin protease cofactor |
genetic |
7 |
2 |
6 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
UBP3 |
YER151C |
Ubiquitin-specific protease that cleaves Ub-protein fusions |
genetic |
7 |
2 |
6 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
BST1 |
YFL025C |
GPI inositol deacylase of the endoplasmic reticulum (ER) |
genetic |
7 |
2 |
6 |
Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
OPI3 |
YJR073C |
Methylene-fatty-acyl-phospholipid synthase |
genetic |
7 |
2 |
6 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
PKR1 |
YMR123W |
V-ATPase assembly factor |
genetic |
7 |
3 |
5 |
Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
COG8 |
YML071C |
Component of the conserved oligomeric Golgi complex |
genetic |
7 |
2 |
5 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
GET3 |
YDL100C |
Guanine nucleotide exchange factor for Gpa1p |
genetic |
7 |
2 |
5 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
COG5 |
YNL051W |
Component of the conserved oligomeric Golgi complex |
genetic |
7 |
2 |
5 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
ERV14 |
YGL054C |
COPII-coated vesicle protein |
genetic |
7 |
2 |
5 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
CKB2 |
YOR039W |
Beta' regulatory subunit of casein kinase 2 (CK2) |
genetic |
7 |
1 |
5 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
VPS8 |
YAL002W |
Membrane-binding component of the CORVET complex |
genetic |
6 |
3 |
6 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
VPS72 |
YDR485C |
Htz1p-binding component of the SWR1 complex |
genetic |
6 |
2 |
6 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
EAF7 |
YNL136W |
Subunit of the NuA4 histone acetyltransferase complex |
genetic |
6 |
2 |
6 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
RXT2 |
YBR095C |
Component of the histone deacetylase Rpd3L complex |
genetic |
6 |
1 |
6 |
Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic |
BUD13 |
YGL174W |
Subunit of the RES complex |
genetic |
6 |
1 |
6 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
MCK1 |
YNL307C |
Dual-specificity ser/thr and tyrosine protein kinase |
genetic |
6 |
1 |
6 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
SLY1 |
YDR189W |
Hydrophilic protein involved in ER/Golgi vesicle trafficking |
genetic |
6 |
4 |
5 |
Dosage Rescue, Synthetic Rescue, Synthetic Lethality, Synthetic Rescue, Negative Genetic, Negative Genetic |
NBP2 |
YDR162C |
Protein involved in the HOG (high osmolarity glycerol) pathway |
genetic |
6 |
3 |
5 |
Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
SWC3 |
YAL011W |
Protein of unknown function |
genetic |
6 |
3 |
5 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
COG6 |
YNL041C |
Component of the conserved oligomeric Golgi complex |
genetic |
6 |
2 |
5 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
RER1 |
YCL001W |
Protein involved in retention of membrane proteins |
genetic |
6 |
2 |
5 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
CSF1 |
YLR087C |
Protein with structural similarity to lipid transport protein Vps13p |
genetic |
6 |
2 |
5 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
CHO2 |
YGR157W |
Phosphatidylethanolamine methyltransferase (PEMT) |
genetic |
6 |
2 |
5 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
PSD1 |
YNL169C |
Phosphatidylserine decarboxylase of the mitochondrial inner membrane |
genetic |
6 |
2 |
5 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
PAT1 |
YCR077C |
Deadenylation-dependent mRNA-decapping factor |
genetic |
6 |
1 |
5 |
Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic |
LSM6 |
YDR378C |
Lsm (Like Sm) protein |
genetic |
6 |
1 |
5 |
Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic |
GIM3 |
YNL153C |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
6 |
1 |
5 |
Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic |
RET2 |
YFR051C |
Delta subunit of the coatomer complex (COPI) |
genetic |
6 |
1 |
5 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
ARP6 |
YLR085C |
Actin-related protein that binds nucleosomes |
genetic |
6 |
3 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
GCS1 |
YDL226C |
ADP-ribosylation factor GTPase activating protein (ARF GAP) |
genetic |
6 |
3 |
4 |
Positive Genetic, Positive Genetic, Synthetic Rescue, Phenotypic Suppression, Positive Genetic, Positive Genetic |
VAM6 |
YDL077C |
Guanine nucleotide exchange factor for the GTPase Gtr1p |
genetic |
6 |
2 |
4 |
Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
EGD1 |
YPL037C |
Subunit beta1 of the nascent polypeptide-associated complex (NAC) |
genetic |
6 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
MVP1 |
YMR004W |
Protein required for sorting proteins to the vacuole |
genetic |
6 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
COG7 |
YGL005C |
Component of the conserved oligomeric Golgi complex |
genetic |
6 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
ENT5 |
YDR153C |
Protein containing an N-terminal epsin-like domain |
genetic |
6 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
MRL1 |
YPR079W |
Membrane protein |
genetic |
6 |
2 |
4 |
Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
UPF3 |
YGR072W |
Component of the nonsense-mediated mRNA decay (NMD) pathway |
genetic |
6 |
2 |
4 |
Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
YPT1 |
YFL038C |
Rab family GTPase |
genetic |
6 |
4 |
3 |
Dosage Rescue, Dosage Growth Defect, Negative Genetic, Negative Genetic, Dosage Rescue, Phenotypic Suppression |
VPS13 |
YLL040C |
Lipid transport protein involved in prospore membrane morphogenesis |
genetic |
6 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
SNX4 |
YJL036W |
Sorting nexin |
genetic |
5 |
4 |
5 |
Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Phenotypic Suppression |
BRE1 |
YDL074C |
E3 ubiquitin ligase |
genetic |
5 |
3 |
5 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
FUN30 |
YAL019W |
Snf2p family member with ATP-dependent chromatin remodeling activity |
genetic |
5 |
2 |
5 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
CNB1 |
YKL190W |
Calcineurin B |
genetic |
5 |
2 |
5 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
STV1 |
YMR054W |
Subunit a of the vacuolar-ATPase V0 domain |
genetic |
5 |
2 |
5 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
SEM1 |
YDR363W-A |
19S proteasome regulatory particle lid subcomplex component |
genetic |
5 |
1 |
5 |
Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic |
APL6 |
YGR261C |
Beta3-like subunit of the yeast AP-3 complex |
genetic |
5 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
SCS2 |
YER120W |
Integral ER membrane protein, regulates phospholipid metabolism |
genetic |
5 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
PEP8 |
YJL053W |
Vacuolar protein component of the retromer |
genetic |
5 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
INP53 |
YOR109W |
Polyphosphatidylinositol phosphatase |
genetic |
5 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
USO1 |
YDL058W |
Essential protein involved in vesicle-mediated ER to Golgi transport |
genetic |
5 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
SEC28 |
YIL076W |
Epsilon-COP subunit of the coatomer |
genetic |
5 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
SFT2 |
YBL102W |
Tetra-spanning membrane protein found mostly in the late Golgi |
genetic |
5 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
IRS4 |
YKR019C |
EH domain-containing protein |
genetic |
5 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
CKB1 |
YGL019W |
Beta regulatory subunit of casein kinase 2 (CK2) |
genetic |
5 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
FAB1 |
YFR019W |
1-phosphatidylinositol-3-phosphate 5-kinase |
genetic |
5 |
1 |
4 |
Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic |
GIM5 |
YML094W |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
5 |
1 |
4 |
Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic |
PBS2 |
YJL128C |
MAP kinase kinase of the HOG signaling pathway |
genetic |
5 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
VPS1 |
YKR001C |
Dynamin-like GTPase required for vacuolar sorting |
genetic |
5 |
3 |
3 |
Negative Genetic, Synthetic Lethality, Synthetic Lethality, Phenotypic Suppression, Phenotypic Suppression |
RAV2 |
YDR202C |
Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) |
genetic |
5 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
SWF1 |
YDR126W |
Palmitoyltransferase that acts on transmembrane proteins |
genetic |
5 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
VAM10 |
YOR068C |
Protein involved in vacuole morphogenesis |
genetic |
5 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
HXK2 |
YGL253W |
Hexokinase isoenzyme 2 |
genetic |
5 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
CDC73 |
YLR418C |
Component of the Paf1p complex |
genetic |
4 |
3 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect |
VPS21 |
YOR089C |
Endosomal Rab family GTPase |
genetic |
4 |
3 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Positive Genetic |
GOS1 |
YHL031C |
v-SNARE protein involved in Golgi transport |
genetic |
4 |
3 |
4 |
Synthetic Lethality, Dosage Rescue, Negative Genetic, Negative Genetic |
LGE1 |
YPL055C |
Protein involved in histone H2B ubiquitination |
genetic |
4 |
3 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect |
SEC27 |
YGL137W |
Essential beta'-coat protein of the COPI coatomer |
genetic |
4 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
TLG1 |
YDR468C |
Essential t-SNARE that mediates fusion of vesicles with the late Golgi |
genetic |
4 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
GET2 |
YER083C |
Subunit of the GET complex |
genetic |
4 |
2 |
4 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
TOP1 |
YOL006C |
Topoisomerase I |
genetic |
4 |
2 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect |
GMH1 |
YKR030W |
Golgi membrane protein of unknown function |
genetic |
4 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
MTC1 |
YJL123C |
Protein of unknown function that may interact with ribosomes |
genetic |
4 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
SKY1 |
YMR216C |
SR protein kinase (SRPK) |
genetic |
4 |
2 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect |
SUM1 |
YDR310C |
Transcriptional repressor that regulates middle-sporulation genes |
genetic |
4 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
ERG3 |
YLR056W |
C-5 sterol desaturase |
genetic |
4 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
RRP6 |
YOR001W |
Nuclear exosome exonuclease component |
genetic |
4 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
LSM7 |
YNL147W |
Lsm (Like Sm) protein |
genetic |
4 |
1 |
4 |
Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic |
PRE9 |
YGR135W |
Alpha 3 subunit of the 20S proteasome |
genetic |
4 |
1 |
4 |
Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic |
SET3 |
YKR029C |
Defining member of the SET3 histone deacetylase complex |
genetic |
4 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
SAP30 |
YMR263W |
Component of Rpd3L histone deacetylase complex |
genetic |
4 |
1 |
4 |
Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic |
SWD1 |
YAR003W |
Subunit of the COMPASS (Set1C) complex |
genetic |
4 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
SDC1 |
YDR469W |
Subunit of the COMPASS (Set1C) complex |
genetic |
4 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
AKL1 |
YBR059C |
Ser/Thr protein kinase |
genetic |
4 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
GCR2 |
YNL199C |
Transcriptional activator of genes involved in glycolysis |
genetic |
4 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
SWI4 |
YER111C |
DNA binding component of the SBF complex (Swi4p-Swi6p) |
genetic |
4 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
DPL1 |
YDR294C |
Dihydrosphingosine phosphate lyase |
genetic |
4 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
SSD1 |
YDR293C |
Translational repressor |
genetic |
4 |
3 |
3 |
Synthetic Lethality, Negative Genetic, Dosage Rescue, Negative Genetic |
MAK3 |
YPR051W |
Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT) |
genetic |
4 |
3 |
3 |
Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
SPO7 |
YAL009W |
Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme |
genetic |
4 |
3 |
3 |
Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Negative Genetic |
RAV1 |
YJR033C |
Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) |
genetic |
4 |
3 |
3 |
Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
GAS1 |
YMR307W |
Beta-1,3-glucanosyltransferase required for cell wall assembly |
genetic |
4 |
3 |
3 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic |
SMI1 |
YGR229C |
Protein involved in the regulation of cell wall synthesis |
genetic |
4 |
3 |
3 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic |
NHX1 |
YDR456W |
Na+/H+ and K+/H+ exchanger |
genetic |
4 |
3 |
3 |
Synthetic Rescue, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
CEX1 |
YOR112W |
Component of nuclear aminoacylation-dependent tRNA export pathway |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
INO4 |
YOL108C |
Transcription factor involved in phospholipid synthesis |
genetic |
4 |
2 |
3 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
APM3 |
YBR288C |
Mu3-like subunit of the clathrin associated protein complex (AP-3) |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
COG2 |
YGR120C |
Essential component of the conserved oligomeric Golgi complex |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
VAM7 |
YGL212W |
Vacuolar SNARE protein |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
YIP1 |
YGR172C |
Integral membrane protein |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic |
SGM1 |
YJR134C |
Protein of unknown function |
physical |
4 |
2 |
3 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western |
CPR7 |
YJR032W |
Peptidyl-prolyl cis-trans isomerase (cyclophilin) |
genetic |
4 |
2 |
3 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
GGA1 |
YDR358W |
Golgi-localized protein with homology to gamma-adaptin |
genetic |
4 |
2 |
3 |
Phenotypic Suppression, Negative Genetic, Negative Genetic, Negative Genetic |
YKT6 |
YKL196C |
Vesicle membrane protein (v-SNARE) with acyltransferase activity |
genetic |
4 |
2 |
3 |
Dosage Rescue, Negative Genetic, Negative Genetic, Negative Genetic |
GEF1 |
YJR040W |
Voltage-gated chloride channel |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
OXR1 |
YPL196W |
Protein involved in regulation of vacuolar V-ATPase |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
COP1 |
YDL145C |
Alpha subunit of COPI vesicle coatomer complex |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
KIN2 |
YLR096W |
S/T protein kinase |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
FAR3 |
YMR052W |
Protein of unknown function |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
UME6 |
YDR207C |
Rpd3L histone deacetylase complex subunit |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
VPS68 |
YOL129W |
Vacuolar membrane protein of unknown function |
genetic |
4 |
1 |
3 |
Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic |
VPS52 |
YDR484W |
Component of the GARP (Golgi-associated retrograde protein) complex |
physical |
4 |
3 |
2 |
Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-Western |
VPS53 |
YJL029C |
Component of the GARP (Golgi-associated retrograde protein) complex |
physical |
4 |
3 |
2 |
Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-Western |
ESA1 |
YOR244W |
Catalytic subunit of the histone acetyltransferase complex (NuA4) |
genetic |
4 |
2 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality |
VPH1 |
YOR270C |
Subunit a of the vacuolar-ATPase V0 domain |
genetic |
4 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
SCS7 |
YMR272C |
Sphingolipid alpha-hydroxylase |
genetic |
4 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
VPS9 |
YML097C |
Guanine nucleotide exchange factor (GEF) and ubiquitin receptor |
genetic |
4 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
BUD14 |
YAR014C |
Protein involved in bud-site selection |
genetic |
3 |
3 |
3 |
Synthetic Lethality, Synthetic Growth Defect, Negative Genetic |
DCR2 |
YLR361C |
Protein phosphatase |
genetic |
3 |
3 |
3 |
Synthetic Lethality, Synthetic Growth Defect, Negative Genetic |
APL5 |
YPL195W |
Delta adaptin-like subunit of the clathrin associated protein complex |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
BNI1 |
YNL271C |
Formin |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect |
DOA1 |
YKL213C |
WD-repeat protein involved in ubiquitin-mediated protein degradation |
genetic |
3 |
2 |
3 |
Positive Genetic, Positive Genetic, Negative Genetic |
GLO3 |
YER122C |
ADP-ribosylation factor GTPase activating protein (ARF GAP) |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
HSP82 |
YPL240C |
Hsp90 chaperone |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect |
RPL2A |
YFR031C-A |
Ribosomal 60S subunit protein L2A |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
MNN10 |
YDR245W |
Subunit of a Golgi mannosyltransferase complex |
genetic |
3 |
2 |
3 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic |
NEM1 |
YHR004C |
Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
SRO9 |
YCL037C |
Cytoplasmic RNA-binding protein |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
PTC1 |
YDL006W |
Type 2C protein phosphatase (PP2C) |
genetic |
3 |
2 |
3 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic |
VMA1 |
YDL185W |
Subunit A of the V1 peripheral membrane domain of V-ATPase |
genetic |
3 |
2 |
3 |
Negative Genetic, Synthetic Lethality, Negative Genetic |
RGP1 |
YDR137W |
Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) |
genetic |
3 |
2 |
3 |
Dosage Rescue, Positive Genetic, Positive Genetic |
GYP6 |
YJL044C |
GTPase-activating protein (GAP) for yeast Rab family member Ypt6p |
physical |
3 |
2 |
3 |
Two-hybrid, Biochemical Activity, Two-hybrid |
MRS6 |
YOR370C |
Rab escort protein |
physical |
3 |
2 |
3 |
PCA, Two-hybrid, PCA |
DSS4 |
YPR017C |
Guanine nucleotide dissociation stimulator for Sec4p |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
PPG1 |
YNR032W |
Serine protein phosphatase involved in formation of FAR complex |
genetic |
3 |
2 |
3 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic |
VAM3 |
YOR106W |
Syntaxin-like vacuolar t-SNARE |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
SWC5 |
YBR231C |
Component of the SWR1 complex |
genetic |
3 |
2 |
3 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic |
SED5 |
YLR026C |
cis-Golgi t-SNARE syntaxin |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
YAF9 |
YNL107W |
Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes |
genetic |
3 |
2 |
3 |
Negative Genetic, Negative Genetic, Synthetic Growth Defect |
MON2 |
YNL297C |
Protein with a role in endocytosis and vacuole integrity |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
GTA1 |
YEL043W |
Protein of unknown function |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
YPT7 |
YML001W |
Rab family GTPase |
genetic |
3 |
2 |
3 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic |
SWA2 |
YDR320C |
Auxilin-like protein involved in vesicular transport |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
GUP1 |
YGL084C |
Plasma membrane protein involved in remodeling GPI anchors |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
CDC50 |
YCR094W |
Endosomal protein that interacts with phospholipid flippase Drs2p |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
TVP15 |
YDR100W |
Integral membrane protein |
genetic |
3 |
2 |
3 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic |
RCE1 |
YMR274C |
Type II CAAX prenyl protease |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
RVB1 |
YDR190C |
ATP-dependent DNA helicase, also known as pontin |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
SAP190 |
YKR028W |
Protein that forms a complex with the Sit4p protein phosphatase |
genetic |
3 |
1 |
3 |
Positive Genetic, Positive Genetic, Positive Genetic |
LRP1 |
YHR081W |
Nuclear exosome-associated nucleic acid binding protein |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
CAF40 |
YNL288W |
Component of the CCR4-NOT transcriptional complex |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
FPR1 |
YNL135C |
Peptidyl-prolyl cis-trans isomerase (PPIase) |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
IWR1 |
YDL115C |
RNA polymerase II transport factor, conserved from yeast to humans |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
PHO23 |
YNL097C |
Component of the Rpd3L histone deacetylase complex |
genetic |
3 |
1 |
3 |
Positive Genetic, Positive Genetic, Positive Genetic |
RPD3 |
YNL330C |
Histone deacetylase, component of both the Rpd3S and Rpd3L complexes |
genetic |
3 |
1 |
3 |
Positive Genetic, Positive Genetic, Positive Genetic |
RXT3 |
YDL076C |
Component of the Rpd3L histone deacetylase complex |
genetic |
3 |
1 |
3 |
Positive Genetic, Positive Genetic, Positive Genetic |
GAL83 |
YER027C |
One of three alternate beta-subunits of the Snf1 kinase complex |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
SNF1 |
YDR477W |
AMP-activated S/T protein kinase |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
BCY1 |
YIL033C |
Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
HIR3 |
YJR140C |
Subunit of the HIR complex |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
RSP5 |
YER125W |
NEDD4 family E3 ubiquitin ligase |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
HIR2 |
YOR038C |
Subunit of HIR nucleosome assembly complex |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
IST3 |
YIR005W |
Component of the U2 snRNP |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
DUO1 |
YGL061C |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
IPK1 |
YDR315C |
Inositol 1,3,4,5,6-pentakisphosphate 2-kinase |
genetic |
3 |
1 |
3 |
Positive Genetic, Positive Genetic, Positive Genetic |
URE2 |
YNL229C |
Nitrogen catabolite repression transcriptional regulator |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
SAC3 |
YDR159W |
mRNA export factor |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
CTF8 |
YHR191C |
Subunit of a complex with Ctf18p |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
OST3 |
YOR085W |
Gamma subunit of the oligosaccharyltransferase complex of the ER lumen |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
NNF2 |
YGR089W |
Protein that exhibits physical and genetic interactions with Rpb8p |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
UME1 |
YPL139C |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
3 |
1 |
3 |
Positive Genetic, Positive Genetic, Positive Genetic |
SUB1 |
YMR039C |
Transcriptional regulator |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
VPS64 |
YDR200C |
Protein required for cytoplasm to vacuole targeting of proteins |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
UBC13 |
YDR092W |
E2 ubiquitin-conjugating enzyme |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
RIC1 |
YLR039C |
Protein involved in retrograde transport to the cis-Golgi network |
physical |
3 |
2 |
2 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS |
ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
3 |
2 |
2 |
Negative Genetic, Positive Genetic, Negative Genetic |
HDA1 |
YNL021W |
Catalytic subunit of class II HDA1 histone deacetylase complex |
genetic |
3 |
2 |
2 |
Negative Genetic, Dosage Lethality, Dosage Lethality |
RET3 |
YPL010W |
Zeta subunit of the coatomer complex (COPI) |
genetic |
3 |
2 |
2 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
SEC23 |
YPR181C |
GTPase-activating protein, stimulates the GTPase activity of Sar1p |
genetic |
3 |
2 |
2 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
VPS54 |
YDR027C |
Component of the GARP (Golgi-associated retrograde protein) complex |
physical |
3 |
2 |
2 |
Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western |
OCA4 |
YCR095C |
Cytoplasmic protein required for replication of Brome mosaic virus |
genetic |
3 |
2 |
2 |
Positive Genetic, Negative Genetic, Positive Genetic |
ILM1 |
YJR118C |
Protein of unknown function |
genetic |
3 |
2 |
2 |
Positive Genetic, Negative Genetic, Negative Genetic |
LCB1 |
YMR296C |
Component of serine palmitoyltransferase |
genetic |
3 |
1 |
2 |
Positive Genetic, Positive Genetic, Positive Genetic |
COG3 |
YER157W |
Essential component of the conserved oligomeric Golgi complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
INP52 |
YNL106C |
Polyphosphatidylinositol phosphatase |
genetic |
3 |
1 |
2 |
Positive Genetic, Positive Genetic, Positive Genetic |
SEC17 |
YBL050W |
Alpha-SNAP cochaperone |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
BET5 |
YML077W |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
TRS20 |
YBR254C |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
FAR11 |
YNL127W |
Protein involved in recovery from cell cycle arrest |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
CMP2 |
YML057W |
Calcineurin A |
genetic |
3 |
1 |
2 |
Positive Genetic, Positive Genetic, Positive Genetic |
MET6 |
YER091C |
Cobalamin-independent methionine synthase |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
UBC7 |
YMR022W |
Ubiquitin conjugating enzyme |
genetic |
3 |
1 |
2 |
Positive Genetic, Positive Genetic, Positive Genetic |
INO2 |
YDR123C |
Transcription factor |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
NMD2 |
YHR077C |
Protein involved in the nonsense-mediated mRNA decay (NMD) pathway |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
VTI1 |
YMR197C |
Protein involved in cis-Golgi membrane traffic |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
ERG5 |
YMR015C |
C-22 sterol desaturase |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
ORM2 |
YLR350W |
Protein that mediates sphingolipid homeostasis |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
SAC1 |
YKL212W |
Phosphatidylinositol phosphate phosphatase |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
RNH70 |
YGR276C |
3'-5' exoribonuclease |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
GPI19 |
YDR437W |
Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
UBX2 |
YML013W |
Bridging factor involved in ER-associated protein degradation (ERAD) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
APS3 |
YJL024C |
Small subunit of the clathrin-associated adaptor complex AP-3 |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
MOD5 |
YOR274W |
Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
ENV9 |
YOR246C |
Conserved oxidoreductase involved in lipid droplet morphology |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
RTF1 |
YGL244W |
Subunit of RNAPII-associated chromatin remodeling Paf1 complex |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
SDS22 |
YKL193C |
Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p |
genetic |
2 |
2 |
2 |
Positive Genetic, Negative Genetic |
EAF1 |
YDR359C |
Component of the NuA4 histone acetyltransferase complex |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
BRR2 |
YER172C |
RNA-dependent ATPase RNA helicase (DEIH box) |
genetic |
2 |
2 |
2 |
Positive Genetic, Negative Genetic |
CBC2 |
YPL178W |
Small subunit of the heterodimeric cap binding complex with Sto1p |
genetic |
2 |
2 |
2 |
Negative Genetic, Positive Genetic |
SUP35 |
YDR172W |
Translation termination factor eRF3 |
genetic |
2 |
2 |
2 |
Positive Genetic, Negative Genetic |
RTT10 |
YPL183C |
WD40 domain-containing protein involved in endosomal recycling |
genetic |
2 |
2 |
2 |
Positive Genetic, Negative Genetic |
CTK1 |
YKL139W |
Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) |
genetic |
2 |
2 |
2 |
Negative Genetic, Positive Genetic |
ESC8 |
YOL017W |
Protein involved in telomeric and mating-type locus silencing |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
MAK10 |
YEL053C |
Non-catalytic subunit of the NatC N-terminal acetyltransferase |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
PRP4 |
YPR178W |
Splicing factor |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Negative Genetic |
NRD1 |
YNL251C |
RNA-binding subunit of Nrd1 complex |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
OPI1 |
YHL020C |
Transcriptional regulator of a variety of genes |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
SEC21 |
YNL287W |
Gamma subunit of coatomer |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
NGG1 |
YDR176W |
Subunit of chromatin modifying histone acetyltransferase complexes |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
MGA2 |
YIR033W |
ER membrane protein involved in regulation of OLE1 transcription |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Negative Genetic |
BRE2 |
YLR015W |
Subunit of COMPASS (Set1C) complex |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
CDC13 |
YDL220C |
Single stranded DNA-binding protein found at TG1-3 telomere G-tails |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Positive Genetic |
HEL2 |
YDR266C |
RING finger ubiquitin ligase (E3) |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Negative Genetic |
SEC18 |
YBR080C |
AAA ATPase and SNARE disassembly chaperone |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
RAD6 |
YGL058W |
Ubiquitin-conjugating enzyme (E2) |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
HHO1 |
YPL127C |
Histone H1, linker histone with roles in meiosis and sporulation |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Rescue |
KIN28 |
YDL108W |
Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly |
genetic |
2 |
2 |
2 |
Positive Genetic, Negative Genetic |
ATG20 |
YDL113C |
Sorting nexin family member |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Negative Genetic |
PAP2 |
YOL115W |
Non-canonical poly(A) polymerase |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
NUP2 |
YLR335W |
Nucleoporin involved in nucleocytoplasmic transport |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Negative Genetic |
TEF4 |
YKL081W |
Gamma subunit of translational elongation factor eEF1B |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
BUB3 |
YOR026W |
Kinetochore checkpoint WD40 repeat protein |
genetic |
2 |
2 |
2 |
Positive Genetic, Negative Genetic |
COG4 |
YPR105C |
Essential component of the conserved oligomeric Golgi complex |
genetic |
2 |
2 |
2 |
Negative Genetic, Phenotypic Suppression |
MDR1 |
YGR100W |
Cytoplasmic GTPase-activating protein |
physical |
2 |
2 |
2 |
Affinity Capture-Western, Biochemical Activity |
FRQ1 |
YDR373W |
N-myristoylated calcium-binding protein |
genetic |
2 |
2 |
2 |
Positive Genetic, Negative Genetic |
SRO7 |
YPR032W |
Effector of Rab GTPase Sec4p |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
CIN1 |
YOR349W |
Tubulin folding factor D involved in beta-tubulin (Tub2p) folding |
genetic |
2 |
2 |
2 |
Positive Genetic, Negative Genetic |
INP51 |
YIL002C |
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
NTO1 |
YPR031W |
Subunit of the NuA3 histone acetyltransferase complex |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Negative Genetic |
DCC1 |
YCL016C |
Subunit of a complex with Ctf8p and Ctf18p |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Negative Genetic |
CYK3 |
YDL117W |
SH3-domain protein located in the bud neck and cytokinetic actin ring |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
ZRT1 |
YGL255W |
High-affinity zinc transporter of the plasma membrane |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
ANY1 |
YMR010W |
Protein involved in phospholipid flippase function |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
SEC14 |
YMR079W |
Phosphatidylinositol/phosphatidylcholine transfer protein |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Positive Genetic |
SYH1 |
YPL105C |
Protein of unknown function that influences nuclear pore distribution |
genetic |
2 |
2 |
2 |
Dosage Rescue, Negative Genetic |
VPS5 |
YOR069W |
Nexin-1 homolog |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
VPS74 |
YDR372C |
Golgi PI4K effector, PtdIns4P sensor, and retention receptor |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
DAT1 |
YML113W |
DNA binding protein that recognizes oligo(dA).oligo(dT) tracts |
genetic |
2 |
2 |
2 |
Positive Genetic, Negative Genetic |
KHA1 |
YJL094C |
Putative K+/H+ antiporter |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
ULS1 |
YOR191W |
Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Negative Genetic |
REB1 |
YBR049C |
RNA polymerase I enhancer binding protein |
regulation |
2 |
1 |
2 |
chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence |
CHD1 |
YER164W |
Chromatin remodeler that regulates various aspects of transcription |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RPB3 |
YIL021W |
RNA polymerase II third largest subunit B44 |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CKA2 |
YOR061W |
Alpha' catalytic subunit of casein kinase 2 (CK2) |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
RVB2 |
YPL235W |
ATP-dependent DNA helicase, also known as reptin |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
EAF5 |
YEL018W |
Non-essential subunit of the NuA4 acetyltransferase complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SAP155 |
YFR040W |
Protein required for function of the Sit4p protein phosphatase |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
THP2 |
YHR167W |
Subunit of the THO and TREX complexes |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
SIN4 |
YNL236W |
Subunit of the RNA polymerase II mediator complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MUD1 |
YBR119W |
U1 snRNP A protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
VIP1 |
YLR410W |
Bifunctional inositol pyrophosphate kinase and phosphatase |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
BET3 |
YKR068C |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
HST1 |
YOL068C |
NAD(+)-dependent histone deacetylase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MED1 |
YPR070W |
Subunit of the RNA polymerase II mediator complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
HSC82 |
YMR186W |
Cytoplasmic chaperone of the Hsp90 family |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
ARP8 |
YOR141C |
Nuclear actin-related protein involved in chromatin remodeling |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
PAC10 |
YGR078C |
Part of the heteromeric co-chaperone GimC/prefoldin complex |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
PDC1 |
YLR044C |
Major of three pyruvate decarboxylase isozymes |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
DEP1 |
YAL013W |
Component of the Rpd3L histone deacetylase complex |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
RCO1 |
YMR075W |
Essential component of the Rpd3S histone deacetylase complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CTI6 |
YPL181W |
Component of the Rpd3L histone deacetylase complex |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
SDS3 |
YIL084C |
Component of the Rpd3L histone deacetylase complex |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
SIN3 |
YOL004W |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
GCN5 |
YGR252W |
Catalytic subunit of ADA and SAGA histone acetyltransferase complexes |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SPT8 |
YLR055C |
Subunit of the SAGA transcriptional regulatory complex |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
RRD2 |
YPL152W |
Peptidyl-prolyl cis/trans-isomerase |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
BCK1 |
YJL095W |
MAPKKK acting in the protein kinase C signaling pathway |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
SNT1 |
YCR033W |
Set3C histone deacetylase scaffold |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
GSF2 |
YML048W |
Endoplasmic reticulum (ER) localized integral membrane protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RVS161 |
YCR009C |
Amphiphysin-like lipid raft protein |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
RGP1 |
YDR137W |
Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
KNS1 |
YLL019C |
Protein kinase involved in negative regulation of PolIII transcription |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
DSK2 |
YMR276W |
Nuclear-enriched ubiquitin-like polyubiquitin-binding protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
OCA1 |
YNL099C |
Putative protein tyrosine phosphatase |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
ERG6 |
YML008C |
Delta(24)-sterol C-methyltransferase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
HIR1 |
YBL008W |
Subunit of the HIR complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
OPY1 |
YBR129C |
Protein of unknown function |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CIK1 |
YMR198W |
Kinesin-associated protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
HAP3 |
YBL021C |
Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
PTC6 |
YCR079W |
Mitochondrial type 2C protein phosphatase (PP2C) |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
UBC4 |
YBR082C |
Ubiquitin-conjugating enzyme (E2) |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
YPT52 |
YKR014C |
Endosomal Rab family GTPase |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
PKH1 |
YDR490C |
Serine/threonine protein kinase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MCM10 |
YIL150C |
Essential chromatin-associated protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CLG1 |
YGL215W |
Cyclin-like protein that interacts with Pho85p |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
BAS1 |
YKR099W |
Myb-related transcription factor |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
ASK10 |
YGR097W |
Regulator of the Fps1p glycerol channel |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MDY2 |
YOL111C |
Protein involved in inserting tail-anchored proteins into ER membranes |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
BOS1 |
YLR078C |
v-SNARE (vesicle specific SNAP receptor) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
ELP4 |
YPL101W |
Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
HPC2 |
YBR215W |
Subunit of the HIR complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RPS8A |
YBL072C |
Protein component of the small (40S) ribosomal subunit |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
ATG8 |
YBL078C |
Ub-like protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
DBF4 |
YDR052C |
Regulatory subunit of Cdc7p-Dbf4p kinase complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MDM12 |
YOL009C |
Mitochondrial outer membrane protein, ERMES complex subunit |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RAP1 |
YNL216W |
Essential DNA-binding transcription regulator that binds many loci |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
HRB1 |
YNL004W |
Poly(A+) RNA-binding protein |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
YIP3 |
YNL044W |
Protein localized to COPII vesicles |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
HAP4 |
YKL109W |
Transcription factor |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
PDR17 |
YNL264C |
Phosphatidylinositol transfer protein (PITP) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MUD2 |
YKL074C |
Protein involved in early pre-mRNA splicing |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
PBP1 |
YGR178C |
Component of glucose deprivation induced stress granules |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
MSB3 |
YNL293W |
Rab GTPase-activating protein |
physical |
2 |
1 |
2 |
Biochemical Activity, Biochemical Activity |
CQD1 |
YPL109C |
UbiB family mitochondrial protein |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
TOM1 |
YDR457W |
E3 ubiquitin ligase of the hect-domain class |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
VPS38 |
YLR360W |
Part of a Vps34p phosphatidylinositol 3-kinase complex |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
ENV11 |
YGR071C |
Protein proposed to be involved in vacuolar functions |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
TFB2 |
YPL122C |
Subunit of TFIIH and nucleotide excision repair factor 3 complexes |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
TEC1 |
YBR083W |
Transcription factor targeting filamentation genes and Ty1 expression |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
MRC1 |
YCL061C |
S-phase checkpoint protein required for DNA replication |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
TPM1 |
YNL079C |
Major isoform of tropomyosin |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
BUG1 |
YDL099W |
Cis-golgi localized protein involved in ER to Golgi transport |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
HCM1 |
YCR065W |
Forkhead transcription factor |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
ALG1 |
YBR110W |
Mannosyltransferase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
VMA3 |
YEL027W |
Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
FAT1 |
YBR041W |
Very long chain fatty acyl-CoA synthetase and fatty acid transporter |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
EDC2 |
YER035W |
RNA-binding protein that directly activates mRNA decapping |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MUK1 |
YPL070W |
Guanine nucleotide exchange factor (GEF) |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
OLE1 |
YGL055W |
Delta(9) fatty acid desaturase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
TBF1 |
YPL128C |
Telobox-containing general regulatory factor |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RIM21 |
YNL294C |
pH sensor molecule, component of the RIM101 pathway |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
TRS31 |
YDR472W |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MUB1 |
YMR100W |
MYND domain-containing protein |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
LDB19 |
YOR322C |
Alpha-arrestin, Ub-ligase adaptor for Rsp5p |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
GPI17 |
YDR434W |
Transmembrane protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RTT106 |
YNL206C |
Histone chaperone |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
THR1 |
YHR025W |
Homoserine kinase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MDM34 |
YGL219C |
Mitochondrial component of the ERMES complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SOK2 |
YMR016C |
Nuclear protein that negatively regulates pseudohyphal differentiation |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
GOT1 |
YMR292W |
Homodimeric protein that is packaged into COPII vesicles |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CCW12 |
YLR110C |
Cell wall mannoprotein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
YKL069W |
YKL069W |
Methionine-R-sulfoxide reductase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
EDC1 |
YGL222C |
RNA-binding protein that activates mRNA decapping directly |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
ATG22 |
YCL038C |
Vacuolar integral membrane protein required for efflux of amino acids |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
YET1 |
YKL065C |
Endoplasmic reticulum transmembrane protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SUR2 |
YDR297W |
Sphinganine C4-hydroxylase |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
LAS21 |
YJL062W |
Mannose-ethanolamine phosphotransferase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CNE1 |
YAL058W |
Calnexin |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
ECT1 |
YGR007W |
Ethanolamine-phosphate cytidylyltransferase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
YKE2 |
YLR200W |
Subunit of the heterohexameric Gim/prefoldin protein complex |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
DBR1 |
YKL149C |
RNA lariat debranching enzyme |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
KRE5 |
YOR336W |
Protein required for beta-1,6 glucan biosynthesis |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
VPS70 |
YJR126C |
Protein of unknown function involved in vacuolar protein sorting |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SEC59 |
YMR013C |
Dolichol kinase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
YKR075C |
YKR075C |
Protein of unknown function |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SEC7 |
YDR170C |
Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors |
genetic |
2 |
2 |
1 |
Negative Genetic, Positive Genetic |
SRN2 |
YLR119W |
Component of the ESCRT-I complex |
genetic |
2 |
2 |
1 |
Negative Genetic, Positive Genetic |
YIP3 |
YNL044W |
Protein localized to COPII vesicles |
physical |
2 |
2 |
1 |
Affinity Capture-Western, Two-hybrid |
MVB12 |
YGR206W |
ESCRT-I subunit required to stabilize ESCRT-I core complex oligomers |
genetic |
2 |
2 |
1 |
Negative Genetic, Positive Genetic |
OCA6 |
YDR067C |
Cytoplasmic protein required for replication of Brome mosaic virus |
genetic |
2 |
2 |
1 |
Negative Genetic, Positive Genetic |
SWC4 |
YGR002C |
Component of the Swr1p complex that incorporates Htz1p into chromatin |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
SAP185 |
YJL098W |
Protein that forms a complex with the Sit4p protein phosphatase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
MLH1 |
YMR167W |
Protein required for mismatch repair in mitosis and meiosis |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
CMD1 |
YBR109C |
Calmodulin |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
HMO1 |
YDR174W |
Chromatin associated high mobility group (HMG) family member |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
PTI1 |
YGR156W |
Essential component of CPF (cleavage and polyadenylation factor) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
SEC26 |
YDR238C |
Essential beta-coat protein of the COPI coatomer |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
SEC63 |
YOR254C |
Essential subunit of Sec63 complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
SLA1 |
YBL007C |
Cytoskeletal protein binding protein |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
PRP18 |
YGR006W |
Splicing factor and component of snRNP U5 |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
RPT4 |
YOR259C |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
GET4 |
YOR164C |
Protein involved in inserting tail-anchored proteins into ER membranes |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
IRA2 |
YOL081W |
GTPase-activating protein |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
IDH1 |
YNL037C |
Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
ARE2 |
YNR019W |
Acyl-CoA:sterol acyltransferase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
PTP3 |
YER075C |
Phosphotyrosine-specific protein phosphatase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
CKI1 |
YLR133W |
Choline kinase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
ASM4 |
YDL088C |
FG-nucleoporin component of central core of nuclear pore complex (NPC) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
QCR6 |
YFR033C |
Subunit 6 of the ubiquinol cytochrome-c reductase complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
ELO3 |
YLR372W |
Elongase |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
HRD1 |
YOL013C |
Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
DPM1 |
YPR183W |
Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
GPI2 |
YPL076W |
Protein involved in the synthesis of GlcNAc-PI |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
MSS1 |
YMR023C |
Mitochondrial protein |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
HFD1 |
YMR110C |
Dehydrogenase involved in ubiquinone and sphingolipid metabolism |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
GEP5 |
YLR091W |
Protein of unknown function |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
SND1 |
YDR186C |
Protein involved in SRP-independent targeting of substrates to the ER |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
ATG21 |
YPL100W |
Phosphoinositide binding protein |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
PIK1 |
YNL267W |
Phosphatidylinositol 4-kinase |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
SYG1 |
YIL047C |
Plasma membrane protein of unknown function |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
GPI8 |
YDR331W |
Catalytic subunit of the ER membrane GPI transamidase complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
SYT1 |
YPR095C |
Guanine nucleotide exchange factor (GEF) for Arf proteins |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
SRF1 |
YDL133W |
Regulator of phospholipase D (Spo14p) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
UPS1 |
YLR193C |
Phosphatidic acid transfer protein |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
UTH1 |
YKR042W |
Mitochondrial inner membrane protein |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
YIR016W |
YIR016W |
Putative protein of unknown function |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
RFX1 |
YLR176C |
Major transcriptional repressor of DNA-damage-regulated genes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
SPT10 |
YJL127C |
Histone H3 acetylase with a role in transcriptional regulation |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
CTR9 |
YOL145C |
Component of the Paf1p complex involved in transcription elongation |
genetic |
1 |
1 |
1 |
Negative Genetic |
CLF1 |
YLR117C |
Member of the NineTeen Complex (NTC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
PAF1 |
YBR279W |
Component of the Paf1p complex involved in transcription elongation |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPO21 |
YDL140C |
RNA polymerase II largest subunit B220 |
genetic |
1 |
1 |
1 |
Negative Genetic |
POB3 |
YML069W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
CKA1 |
YIL035C |
Alpha catalytic subunit of casein kinase 2 (CK2) |
genetic |
1 |
1 |
1 |
Negative Genetic |
TFG1 |
YGR186W |
TFIIF (Transcription Factor II) largest subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
GLC7 |
YER133W |
Type 1 S/T protein phosphatase (PP1) catalytic subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
ARP4 |
YJL081C |
Nuclear actin-related protein involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Negative Genetic |
NOP2 |
YNL061W |
rRNA m5C methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
PFK27 |
YOL136C |
6-phosphofructo-2-kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
PRP19 |
YLL036C |
Splicing factor associated with the spliceosome |
genetic |
1 |
1 |
1 |
Negative Genetic |
POP4 |
YBR257W |
Subunit of both RNase MRP and nuclear RNase P |
genetic |
1 |
1 |
1 |
Negative Genetic |
RMP1 |
YLR145W |
Subunit of RNase MRP |
genetic |
1 |
1 |
1 |
Negative Genetic |
PRP43 |
YGL120C |
RNA helicase in the DEAH-box family |
genetic |
1 |
1 |
1 |
Negative Genetic |
PRP8 |
YHR165C |
Component of U4/U6-U5 snRNP complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
NSE4 |
YDL105W |
Component of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
HAP5 |
YOR358W |
Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
KES1 |
YPL145C |
Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger |
genetic |
1 |
1 |
1 |
Negative Genetic |
ARC1 |
YGL105W |
Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases |
genetic |
1 |
1 |
1 |
Negative Genetic |
MDM20 |
YOL076W |
Non-catalytic subunit of the NatB N-terminal acetyltransferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
PUS7 |
YOR243C |
Pseudouridine synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
LSM3 |
YLR438C-A |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
PAB1 |
YER165W |
Poly(A) binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
NPL3 |
YDR432W |
RNA-binding protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RRP9 |
YPR137W |
Protein involved in pre-rRNA processing |
genetic |
1 |
1 |
1 |
Positive Genetic |
DIS3 |
YOL021C |
Exosome core complex catalytic subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
RPA34 |
YJL148W |
RNA polymerase I subunit A34.5 |
genetic |
1 |
1 |
1 |
Negative Genetic |
RET1 |
YOR207C |
Second-largest subunit of RNA polymerase III |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
RPA49 |
YNL248C |
RNA polymerase I subunit A49 |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPB7 |
YDR404C |
RNA polymerase II subunit B16 |
genetic |
1 |
1 |
1 |
Negative Genetic |
GCD11 |
YER025W |
Gamma subunit of the translation initiation factor eIF2 |
genetic |
1 |
1 |
1 |
Positive Genetic |
RSC8 |
YFR037C |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
NUT1 |
YGL151W |
Component of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPN6 |
YDL097C |
Essential, non-ATPase regulatory subunit of the 26S proteasome lid |
genetic |
1 |
1 |
1 |
Positive Genetic |
RPN12 |
YFR052W |
Subunit of the 19S regulatory particle of the 26S proteasome lid |
genetic |
1 |
1 |
1 |
Positive Genetic |
UBP6 |
YFR010W |
Ubiquitin-specific protease |
genetic |
1 |
1 |
1 |
Negative Genetic |
HCR1 |
YLR192C |
eIF3j component of translation initiation factor 3 (eIF3) |
genetic |
1 |
1 |
1 |
Negative Genetic |
SRP1 |
YNL189W |
Karyopherin alpha homolog |
genetic |
1 |
1 |
1 |
Negative Genetic |
PTA1 |
YAL043C |
Subunit of holo-CPF |
genetic |
1 |
1 |
1 |
Negative Genetic |
PRE2 |
YPR103W |
Beta 5 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Positive Genetic |
PRE5 |
YMR314W |
Alpha 6 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Positive Genetic |
PRE6 |
YOL038W |
Alpha 4 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Positive Genetic |
BCP1 |
YDR361C |
Essential nuclear chaperone for ribosomal protein Rpl23p |
genetic |
1 |
1 |
1 |
Negative Genetic |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
PEP1 |
YBL017C |
Type I transmembrane sorting receptor for multiple vacuolar hydrolases |
genetic |
1 |
1 |
1 |
Negative Genetic |
ACC1 |
YNR016C |
Acetyl-CoA carboxylase, biotin containing enzyme |
genetic |
1 |
1 |
1 |
Positive Genetic |
ATG14 |
YBR128C |
Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I |
genetic |
1 |
1 |
1 |
Negative Genetic |
ARC18 |
YLR370C |
Subunit of the ARP2/3 complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
ARD1 |
YHR013C |
Subunit of protein N-terminal acetyltransferase NatA |
genetic |
1 |
1 |
1 |
Positive Genetic |
ARP3 |
YJR065C |
Essential component of the Arp2/3 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
ASF1 |
YJL115W |
Nucleosome assembly factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
BEM1 |
YBR200W |
Protein containing SH3-domains |
genetic |
1 |
1 |
1 |
Negative Genetic |
BET2 |
YPR176C |
Beta subunit of Type II geranylgeranyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
BEM2 |
YER155C |
Rho GTPase activating protein (RhoGAP) |
genetic |
1 |
1 |
1 |
Negative Genetic |
CAP1 |
YKL007W |
Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p) |
genetic |
1 |
1 |
1 |
Positive Genetic |
CCA1 |
YER168C |
ATP (CTP):tRNA-specific tRNA nucleotidyltransferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
CCL1 |
YPR025C |
Cyclin partner of the cyclin-dependent kinase (CDK) Kin28p |
genetic |
1 |
1 |
1 |
Negative Genetic |
ERG26 |
YGL001C |
C-3 sterol dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
CKS1 |
YBR135W |
Cyclin-dependent protein kinase regulatory subunit and adaptor |
genetic |
1 |
1 |
1 |
Negative Genetic |
CLP1 |
YOR250C |
Component of the cleavage and polyadenylation factor I (CF I) |
genetic |
1 |
1 |
1 |
Negative Genetic |
CTF18 |
YMR078C |
Subunit of a complex with Ctf8p |
genetic |
1 |
1 |
1 |
Negative Genetic |
CYS4 |
YGR155W |
Cystathionine beta-synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
DCP2 |
YNL118C |
Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC23 |
YHR166C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
EDE1 |
YBL047C |
Scaffold protein involved in the formation of early endocytic sites |
genetic |
1 |
1 |
1 |
Positive Genetic |
ELP2 |
YGR200C |
Subunit of Elongator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
EMP24 |
YGL200C |
Component of the p24 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
ERP1 |
YAR002C-A |
Member of the p24 family involved in ER to Golgi transport |
genetic |
1 |
1 |
1 |
Negative Genetic |
GCN1 |
YGL195W |
Positive regulator of the Gcn2p kinase activity |
genetic |
1 |
1 |
1 |
Negative Genetic |
GGA2 |
YHR108W |
Protein that regulates Arf1p, Arf2p to facilitate Golgi trafficking |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
ERV25 |
YML012W |
Member of the p24 family involved in ER to Golgi transport |
genetic |
1 |
1 |
1 |
Negative Genetic |
ESP1 |
YGR098C |
Separase/separin, a caspase-like cysteine protease |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
HHF1 |
YBR009C |
Histone H4 |
genetic |
1 |
1 |
1 |
Negative Genetic |
DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
genetic |
1 |
1 |
1 |
Negative Genetic |
KGD2 |
YDR148C |
Dihydrolipoyl transsuccinylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
KIN3 |
YAR018C |
Nonessential serine/threonine protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
LCB2 |
YDR062W |
Component of serine palmitoyltransferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
LSM4 |
YER112W |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
MED11 |
YMR112C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
MOT1 |
YPL082C |
Essential protein involved in regulation of transcription |
genetic |
1 |
1 |
1 |
Negative Genetic |
HSC82 |
YMR186W |
Cytoplasmic chaperone of the Hsp90 family |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MSH2 |
YOL090W |
Protein that binds to DNA mismatches |
genetic |
1 |
1 |
1 |
Positive Genetic |
MPH1 |
YIR002C |
3'-5' DNA helicase involved in error-free bypass of DNA lesions |
genetic |
1 |
1 |
1 |
Negative Genetic |
ITC1 |
YGL133W |
Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
IES1 |
YFL013C |
Subunit of the INO80 chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
ATG18 |
YFR021W |
Phosphoinositide binding protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
NIC96 |
YFR002W |
Linker nucleoporin component of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
APM1 |
YPL259C |
Mu1-like medium subunit of the AP-1 complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
DOA4 |
YDR069C |
Ubiquitin hydrolase |
genetic |
1 |
1 |
1 |
Negative Genetic |
PDA1 |
YER178W |
E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
DIG1 |
YPL049C |
MAP kinase-responsive inhibitor of the Ste12p transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
PEP3 |
YLR148W |
Component of CORVET membrane tethering complex |
genetic |
1 |
1 |
1 |
Dosage Rescue |
POP7 |
YBR167C |
Subunit of RNase MRP, nuclear RNase P and telomerase |
genetic |
1 |
1 |
1 |
Positive Genetic |
HSP82 |
YPL240C |
Hsp90 chaperone |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PRE4 |
YFR050C |
Beta 7 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Positive Genetic |
LEA1 |
YPL213W |
Component of U2 snRNP complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
PTC4 |
YBR125C |
Cytoplasmic type 2C protein phosphatase (PP2C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
MET18 |
YIL128W |
Component of cytosolic iron-sulfur protein assembly (CIA) machinery |
genetic |
1 |
1 |
1 |
Positive Genetic |
RAD3 |
YER171W |
5' to 3' DNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
RNA14 |
YMR061W |
Component of the cleavage and polyadenylation factor I (CF I) |
genetic |
1 |
1 |
1 |
Positive Genetic |
PGD1 |
YGL025C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPB11 |
YOL005C |
RNA polymerase II subunit B12.5 |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPB10 |
YOR210W |
RNA polymerase subunit ABC10-beta |
genetic |
1 |
1 |
1 |
Negative Genetic |
MAF1 |
YDR005C |
Highly conserved negative regulator of RNA polymerase III |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
RPC53 |
YDL150W |
RNA polymerase III subunit C53 |
genetic |
1 |
1 |
1 |
Negative Genetic |
CSI1 |
YMR025W |
Subunit of the Cop9 signalosome |
genetic |
1 |
1 |
1 |
Positive Genetic |
VPS51 |
YKR020W |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SAM1 |
YLR180W |
S-adenosylmethionine synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
HOS2 |
YGL194C |
Histone deacetylase and subunit of Set3 and Rpd3L complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
SIF2 |
YBR103W |
WD40 repeat-containing subunit of Set3C histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
HOS4 |
YIL112W |
Subunit of the Set3 complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
SIR2 |
YDL042C |
Conserved NAD+ dependent histone deacetylase of the Sirtuin family |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CCT2 |
YIL142W |
Subunit beta of the cytosolic chaperonin Cct ring complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
ECM25 |
YJL201W |
Endocytic site protein required for stress-induced cell elongation |
genetic |
1 |
1 |
1 |
Negative Genetic |
SLC1 |
YDL052C |
1-acyl-sn-glycerol-3-phosphate acyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
PRP9 |
YDL030W |
Subunit of the SF3a splicing factor complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SME1 |
YOR159C |
Core Sm protein Sm E |
genetic |
1 |
1 |
1 |
Negative Genetic |
BRR1 |
YPR057W |
snRNP protein component of spliceosomal snRNPs |
genetic |
1 |
1 |
1 |
Negative Genetic |
SNF12 |
YNR023W |
73 kDa subunit of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SNF5 |
YBR289W |
Subunit of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
PFK2 |
YMR205C |
Beta subunit of heterooctameric phosphofructokinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
HFI1 |
YPL254W |
Adaptor protein required for structural integrity of the SAGA complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
MLP1 |
YKR095W |
Myosin-like protein associated with the nuclear envelope |
genetic |
1 |
1 |
1 |
Positive Genetic |
SGV1 |
YPR161C |
Cyclin (Bur2p)-dependent protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
STT3 |
YGL022W |
Catalytic subunit of the oligosaccharyltransferase complex of the ER l |
genetic |
1 |
1 |
1 |
Negative Genetic |
TAF1 |
YGR274C |
TFIID subunit, involved in RNA pol II transcription initiation |
genetic |
1 |
1 |
1 |
Negative Genetic |
TAF13 |
YML098W |
TFIID subunit (19 kDa) |
genetic |
1 |
1 |
1 |
Negative Genetic |
SBP1 |
YHL034C |
Protein that binds eIF4G and has a role in repression of translation |
genetic |
1 |
1 |
1 |
Negative Genetic |
NEW1 |
YPL226W |
Translation termination and ribosome biogenesis factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
MCM2 |
YBL023C |
Protein involved in DNA replication |
genetic |
1 |
1 |
1 |
Negative Genetic |
TPS1 |
YBR126C |
Synthase subunit of trehalose-6-P synthase/phosphatase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
UBA3 |
YPR066W |
Protein that activates Rub1p (NEDD8) before neddylation |
genetic |
1 |
1 |
1 |
Positive Genetic |
ACE2 |
YLR131C |
Transcription factor required for septum destruction after cytokinesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
VMA10 |
YHR039C-A |
Subunit G of the V1 peripheral membrane domain of V-ATPase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
VMA7 |
YGR020C |
Subunit F of the V1 peripheral membrane domain of V-ATPase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
VAM6 |
YDL077C |
Guanine nucleotide exchange factor for the GTPase Gtr1p |
physical |
1 |
1 |
1 |
Two-hybrid |
VPS33 |
YLR396C |
ATP-binding protein that is a subunit of the HOPS and CORVET complexes |
physical |
1 |
1 |
1 |
Two-hybrid |
VPS53 |
YJL029C |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
VRP1 |
YLR337C |
Verprolin, proline-rich actin-associated protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
FLC2 |
YAL053W |
Putative calcium channel involved in calcium release under hypotonic |
genetic |
1 |
1 |
1 |
Negative Genetic |
SET1 |
YHR119W |
Histone methyltransferase, subunit of the COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPP1 |
YPL138C |
Subunit of COMPASS (Set1C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
PIN4 |
YBL051C |
Protein involved in G2/M phase progression and response to DNA damage |
genetic |
1 |
1 |
1 |
Positive Genetic |
SSZ1 |
YHR064C |
Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SSU72 |
YNL222W |
Phosphatase and transcription/RNA-processing factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
ABP1 |
YCR088W |
Actin-binding protein of the cortical actin cytoskeleton |
genetic |
1 |
1 |
1 |
Positive Genetic |
CRZ1 |
YNL027W |
Transcription factor, activates transcription of stress response genes |
genetic |
1 |
1 |
1 |
Positive Genetic |
ACO1 |
YLR304C |
Aconitase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
FAR8 |
YMR029C |
Protein involved in recovery from arrest in response to pheromone |
genetic |
1 |
1 |
1 |
Negative Genetic |
ADR1 |
YDR216W |
Carbon source-responsive zinc-finger transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
MMS2 |
YGL087C |
Ubiquitin-conjugating enzyme variant |
genetic |
1 |
1 |
1 |
Negative Genetic |
PHO85 |
YPL031C |
Cyclin-dependent kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
ADO1 |
YJR105W |
Adenosine kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
RIM15 |
YFL033C |
Protein kinase involved in cell proliferation in response to nutrients |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
VPS1 |
YKR001C |
Dynamin-like GTPase required for vacuolar sorting |
physical |
1 |
1 |
1 |
Two-hybrid |
NMD5 |
YJR132W |
Karyopherin |
genetic |
1 |
1 |
1 |
Positive Genetic |
BUB2 |
YMR055C |
Mitotic exit network regulator |
genetic |
1 |
1 |
1 |
Negative Genetic |
SOD1 |
YJR104C |
Cytosolic copper-zinc superoxide dismutase |
genetic |
1 |
1 |
1 |
Positive Genetic |
YCK1 |
YHR135C |
Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform |
genetic |
1 |
1 |
1 |
Negative Genetic |
SEC53 |
YFL045C |
Phosphomannomutase |
genetic |
1 |
1 |
1 |
Positive Genetic |
SUI2 |
YJR007W |
Alpha subunit of the translation initiation factor eIF2 |
genetic |
1 |
1 |
1 |
Positive Genetic |
TPS2 |
YDR074W |
Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
PBR1 |
YNL181W |
Putative oxidoreductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
PCT1 |
YGR202C |
Cholinephosphate cytidylyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
CBK1 |
YNL161W |
Serine/threonine protein kinase of the the RAM signaling network |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
MRS6 |
YOR370C |
Rab escort protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
GAC1 |
YOR178C |
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPN14 |
YGL004C |
Evolutionarily conserved 19S regulatory particle assembly-chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
SFP1 |
YLR403W |
Regulates transcription of ribosomal protein and biogenesis genes |
genetic |
1 |
1 |
1 |
Negative Genetic |
FAR10 |
YLR238W |
Protein involved in recovery from arrest in response to pheromone |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPO12 |
YHR152W |
Nucleolar protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
RNA1 |
YMR235C |
GTPase activating protein (GAP) for Gsp1p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RVS167 |
YDR388W |
Calmodulin-binding actin-associated protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
RAD18 |
YCR066W |
E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
RSN1 |
YMR266W |
Membrane protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
ADD66 |
YKL206C |
Protein involved in 20S proteasome assembly |
genetic |
1 |
1 |
1 |
Positive Genetic |
CIN8 |
YEL061C |
Bipolar kinesin motor protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
DIA2 |
YOR080W |
Origin-binding F-box protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CTF4 |
YPR135W |
Chromatin-associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
RAS2 |
YNL098C |
GTP-binding protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
BUD7 |
YOR299W |
Member of the ChAPs family (Chs5p-Arf1p-binding proteins) |
genetic |
1 |
1 |
1 |
Negative Genetic |
SLT2 |
YHR030C |
Serine/threonine MAP kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
BEM4 |
YPL161C |
Protein involved in establishment of cell polarity and bud emergence |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
HOM3 |
YER052C |
Aspartate kinase (L-aspartate 4-P-transferase) |
genetic |
1 |
1 |
1 |
Positive Genetic |
FPK1 |
YNR047W |
Ser/Thr protein kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
SWI5 |
YDR146C |
Transcription factor that recruits Mediator and Swi/Snf complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
NOP53 |
YPL146C |
Nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
RTT103 |
YDR289C |
Protein involved in transcription termination by RNA polymerase II |
genetic |
1 |
1 |
1 |
Negative Genetic |
ELC1 |
YPL046C |
Elongin C, conserved among eukaryotes |
genetic |
1 |
1 |
1 |
Positive Genetic |
VAN1 |
YML115C |
Component of the mannan polymerase I |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPT2 |
YER161C |
Protein involved in negative regulation of transcription |
genetic |
1 |
1 |
1 |
Positive Genetic |
VPS21 |
YOR089C |
Endosomal Rab family GTPase |
physical |
1 |
1 |
1 |
Two-hybrid |
NDE1 |
YMR145C |
Mitochondrial external NADH dehydrogenase |
genetic |
1 |
1 |
1 |
Positive Genetic |
RAD53 |
YPL153C |
DNA damage response kinase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SAN1 |
YDR143C |
Ubiquitin-protein ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
CTR1 |
YPR124W |
High-affinity copper transporter of plasma membrane |
genetic |
1 |
1 |
1 |
Negative Genetic |
SSL2 |
YIL143C |
Component of RNA polymerase transcription factor TFIIH holoenzyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
MSG5 |
YNL053W |
Dual-specificity protein phosphatase |
genetic |
1 |
1 |
1 |
Positive Genetic |
FCF1 |
YDR339C |
PINc domain endonuclease |
genetic |
1 |
1 |
1 |
Positive Genetic |
RAD26 |
YJR035W |
Protein involved in transcription-coupled nucleotide excision repair |
genetic |
1 |
1 |
1 |
Positive Genetic |
ATG5 |
YPL149W |
Conserved protein involved in autophagy and the Cvt pathway |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
CDH1 |
YGL003C |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Positive Genetic |
PHO86 |
YJL117W |
Endoplasmic reticulum (ER) resident protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
VMA8 |
YEL051W |
Subunit D of the V1 peripheral membrane domain of V-ATPase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
MGT1 |
YDL200C |
DNA repair methyltransferase (6-O-methylguanine-DNA methylase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC7 |
YDL017W |
S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) |
genetic |
1 |
1 |
1 |
Positive Genetic |
YPT52 |
YKR014C |
Endosomal Rab family GTPase |
physical |
1 |
1 |
1 |
Two-hybrid |
NUP133 |
YKR082W |
Subunit of Nup84p subcomplex of nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
APL4 |
YPR029C |
Gamma-adaptin |
genetic |
1 |
1 |
1 |
Positive Genetic |
ASI3 |
YNL008C |
Subunit of the inner nuclear membrane Asi ubiquitin ligase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
ATP7 |
YKL016C |
Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
TVP23 |
YDR084C |
Integral membrane protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
YIP4 |
YGL198W |
Protein that interacts with Rab GTPases |
physical |
1 |
1 |
1 |
Reconstituted Complex |
CLN3 |
YAL040C |
G1 cyclin involved in cell cycle progression |
genetic |
1 |
1 |
1 |
Positive Genetic |
BIM1 |
YER016W |
Microtubule plus end-tracking protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
ENT3 |
YJR125C |
Protein containing an N-terminal epsin-like domain |
genetic |
1 |
1 |
1 |
Negative Genetic |
CUP2 |
YGL166W |
Copper-binding transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
BNI4 |
YNL233W |
Targeting subunit for Glc7p protein phosphatase |
genetic |
1 |
1 |
1 |
Positive Genetic |
GTR1 |
YML121W |
Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
MOB2 |
YFL034C-B |
Activator of Cbk1p kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MAD3 |
YJL013C |
Subunit of spindle-assembly checkpoint complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
MSN5 |
YDR335W |
Karyopherin |
genetic |
1 |
1 |
1 |
Negative Genetic |
COG2 |
YGR120C |
Essential component of the conserved oligomeric Golgi complex |
physical |
1 |
1 |
1 |
Reconstituted Complex |
HSP10 |
YOR020C |
Mitochondrial matrix co-chaperonin |
genetic |
1 |
1 |
1 |
Negative Genetic |
NUP57 |
YGR119C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
MND2 |
YIR025W |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RAD4 |
YER162C |
Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
RIM101 |
YHL027W |
Cys2His2 zinc-finger transcriptional repressor |
genetic |
1 |
1 |
1 |
Positive Genetic |
IME1 |
YJR094C |
Master regulator of meiosis that is active only during meiotic events |
genetic |
1 |
1 |
1 |
Positive Genetic |
GNP1 |
YDR508C |
Broad specificity amino acid permease |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC34 |
YDR054C |
Ubiquitin-conjugating enzyme (E2) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
PET191 |
YJR034W |
Protein required for assembly of cytochrome c oxidase |
genetic |
1 |
1 |
1 |
Positive Genetic |
SRL2 |
YLR082C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
STD1 |
YOR047C |
Protein involved in control of glucose-regulated gene expression |
genetic |
1 |
1 |
1 |
Negative Genetic |
STB2 |
YMR053C |
Protein that interacts with Sin3p in a two-hybrid assay |
genetic |
1 |
1 |
1 |
Negative Genetic |
VMA22 |
YHR060W |
Protein that is required for vacuolar H+-ATPase (V-ATPase) function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
BMT2 |
YBR141C |
Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SLM1 |
YIL105C |
Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p |
genetic |
1 |
1 |
1 |
Positive Genetic |
KEG1 |
YFR042W |
Integral membrane protein of the ER |
genetic |
1 |
1 |
1 |
Negative Genetic |
UGA4 |
YDL210W |
GABA (gamma-aminobutyrate) permease |
genetic |
1 |
1 |
1 |
Negative Genetic |
AKR2 |
YOR034C |
Ankyrin repeat-containing protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
YIP5 |
YGL161C |
Protein that interacts with Rab GTPases |
genetic |
1 |
1 |
1 |
Negative Genetic |
YIF1 |
YNL263C |
Integral membrane protein |
physical |
1 |
1 |
1 |
Reconstituted Complex |
GPI16 |
YHR188C |
Subunit of the glycosylphosphatidylinositol transamidase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
OCA2 |
YNL056W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
APC5 |
YOR249C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
CWC15 |
YDR163W |
Non-essential protein involved in pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Positive Genetic |
COG1 |
YGL223C |
Essential component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
COG6 |
YNL041C |
Component of the conserved oligomeric Golgi complex |
physical |
1 |
1 |
1 |
Two-hybrid |
RPS4A |
YJR145C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
RSC1 |
YGR056W |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RTG1 |
YOL067C |
Transcription factor (bHLH) involved in interorganelle communication |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPT3 |
YDR392W |
Subunit of the SAGA and SAGA-like transcriptional regulatory complexes |
genetic |
1 |
1 |
1 |
Positive Genetic |
IES2 |
YNL215W |
Protein that associates with the INO80 chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
IES4 |
YOR189W |
Component of the INO80 chromatiin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SAS3 |
YBL052C |
Histone acetyltransferase catalytic subunit of NuA3 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SWI3 |
YJL176C |
Subunit of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
CBF1 |
YJR060W |
Basic helix-loop-helix (bHLH) protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
PHO4 |
YFR034C |
Basic helix-loop-helix (bHLH) transcription factor of the myc-family |
genetic |
1 |
1 |
1 |
Negative Genetic |
RTG3 |
YBL103C |
bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways |
genetic |
1 |
1 |
1 |
Negative Genetic |
SCL1 |
YGL011C |
Alpha 1 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Positive Genetic |
BUR6 |
YER159C |
Subunit of a heterodimeric NC2 transcription regulator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
CLC1 |
YGR167W |
Clathrin light chain |
genetic |
1 |
1 |
1 |
Negative Genetic |
DBP5 |
YOR046C |
Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family |
genetic |
1 |
1 |
1 |
Positive Genetic |
ELO2 |
YCR034W |
Fatty acid elongase, involved in sphingolipid biosynthesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
MPS1 |
YDL028C |
Dual-specificity kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
MYO5 |
YMR109W |
One of two type I myosin motors |
genetic |
1 |
1 |
1 |
Positive Genetic |
NIS1 |
YNL078W |
Protein involved in axial bud site selection |
genetic |
1 |
1 |
1 |
Negative Genetic |
PAN1 |
YIR006C |
Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p |
genetic |
1 |
1 |
1 |
Positive Genetic |
PHO80 |
YOL001W |
Cyclin |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPA14 |
YDR156W |
RNA polymerase I subunit A14 |
genetic |
1 |
1 |
1 |
Positive Genetic |
SAS4 |
YDR181C |
Subunit of the SAS complex (Sas2p, Sas4p, Sas5p) |
genetic |
1 |
1 |
1 |
Positive Genetic |
SBH1 |
YER087C-B |
Beta subunit of Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SEC20 |
YDR498C |
Membrane glycoprotein v-SNARE |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
RRD1 |
YIL153W |
Peptidyl-prolyl cis/trans-isomerase |
genetic |
1 |
1 |
1 |
Positive Genetic |
SKN7 |
YHR206W |
Nuclear response regulator and transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
RCY1 |
YJL204C |
F-box protein involved in recycling endocytosed proteins |
genetic |
1 |
1 |
1 |
Negative Genetic |
SSN3 |
YPL042C |
Component of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
STE20 |
YHL007C |
Cdc42p-activated signal transducing kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
STE6 |
YKL209C |
Plasma membrane ATP-binding cassette (ABC) transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
TUB4 |
YLR212C |
Gamma-tubulin |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VPS41 |
YDR080W |
Subunit of the HOPS endocytic tethering complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
TRA1 |
YHR099W |
Subunit of SAGA and NuA4 histone acetyltransferase complexes |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
YIP1 |
YGR172C |
Integral membrane protein |
physical |
1 |
1 |
1 |
Two-hybrid |
CCZ1 |
YBR131W |
Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) |
genetic |
1 |
1 |
1 |
Negative Genetic |
PHO2 |
YDL106C |
Homeobox transcription factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
SEC16 |
YPL085W |
COPII vesicle coat protein required for ER transport vesicle budding |
genetic |
1 |
1 |
1 |
Negative Genetic |
SSN2 |
YDR443C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
OST4 |
YDL232W |
Subunit of the oligosaccharyltransferase complex of the ER lumen |
genetic |
1 |
1 |
1 |
Negative Genetic |
GLN3 |
YER040W |
Transcriptional activator in nitrogen catabolite repression system |
genetic |
1 |
1 |
1 |
Positive Genetic |
GAP1 |
YKR039W |
General amino acid permease |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SEC24 |
YIL109C |
Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat |
genetic |
1 |
1 |
1 |
Negative Genetic |
MPT5 |
YGL178W |
mRNA-binding protein of the PUF family |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
YOP1 |
YPR028W |
Reticulon-interacting protein |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
VPS54 |
YDR027C |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SRM1 |
YGL097W |
Nucleotide exchange factor for Gsp1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
CSG2 |
YBR036C |
Endoplasmic reticulum membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
SEC2 |
YNL272C |
Guanyl-nucleotide exchange factor for the small G-protein Sec4p |
genetic |
1 |
1 |
1 |
Negative Genetic |
CCS1 |
YMR038C |
Copper chaperone for superoxide dismutase Sod1p |
genetic |
1 |
1 |
1 |
Positive Genetic |
PCL5 |
YHR071W |
Cyclin |
genetic |
1 |
1 |
1 |
Positive Genetic |
STE50 |
YCL032W |
Adaptor protein for various signaling pathways |
genetic |
1 |
1 |
1 |
Positive Genetic |
VPS4 |
YPR173C |
AAA-ATPase involved in multivesicular body (MVB) protein sorting |
genetic |
1 |
1 |
1 |
Negative Genetic |
BUD6 |
YLR319C |
Actin- and formin-interacting protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
ERG25 |
YGR060W |
C-4 methyl sterol oxidase |
genetic |
1 |
1 |
1 |
Negative Genetic |
ESC1 |
YMR219W |
Protein involved in telomeric silencing |
genetic |
1 |
1 |
1 |
Negative Genetic |
CAD1 |
YDR423C |
AP-1-like basic leucine zipper (bZIP) transcriptional activator |
genetic |
1 |
1 |
1 |
Negative Genetic |
MAC1 |
YMR021C |
Copper-sensing transcription factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
MON1 |
YGL124C |
Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) |
genetic |
1 |
1 |
1 |
Negative Genetic |
IVY1 |
YDR229W |
Phospholipid-binding protein that interacts with both Ypt7p and Vps33p |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
SEN2 |
YLR105C |
Subunit of the tRNA splicing endonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
SHO1 |
YER118C |
Transmembrane osmosensor for filamentous growth and HOG pathways |
genetic |
1 |
1 |
1 |
Negative Genetic |
AZF1 |
YOR113W |
Zinc-finger transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
MSB4 |
YOL112W |
GTPase-activating protein of the Ras superfamily |
physical |
1 |
1 |
1 |
Biochemical Activity |
PFY1 |
YOR122C |
Profilin |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
TOR1 |
YJR066W |
PIK-related protein kinase and rapamycin target |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SUR1 |
YPL057C |
Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MNN11 |
YJL183W |
Subunit of a Golgi mannosyltransferase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
MSL5 |
YLR116W |
Component of commitment complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
PMT2 |
YAL023C |
Protein O-mannosyltransferase of the ER membrane |
genetic |
1 |
1 |
1 |
Negative Genetic |
CAP2 |
YIL034C |
Beta subunit of the capping protein heterodimer (Cap1p and Cap2p) |
genetic |
1 |
1 |
1 |
Positive Genetic |
NVJ1 |
YHR195W |
Nuclear envelope protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
HAC1 |
YFL031W |
Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RIM20 |
YOR275C |
Protein involved in proteolytic activation of Rim101p |
genetic |
1 |
1 |
1 |
Positive Genetic |
NUP188 |
YML103C |
Subunit of the inner ring of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
EIS1 |
YMR031C |
Component of the eisosome required for proper eisosome assembly |
genetic |
1 |
1 |
1 |
Positive Genetic |
MID1 |
YNL291C |
Stretch-activated Ca2+-permeable cation channel |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
BET4 |
YJL031C |
Alpha subunit of Type II geranylgeranyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
VMA11 |
YPL234C |
Vacuolar ATPase V0 domain subunit c' |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
STB5 |
YHR178W |
Transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPN4 |
YDL020C |
Transcription factor that stimulates expression of proteasome genes |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SSB2 |
YNL209W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
1 |
1 |
1 |
Co-purification |
SOH1 |
YGL127C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPL28 |
YGL103W |
Ribosomal 60S subunit protein L28 |
genetic |
1 |
1 |
1 |
Negative Genetic |
MOG1 |
YJR074W |
Conserved nuclear protein that interacts with GTP-Gsp1p |
genetic |
1 |
1 |
1 |
Positive Genetic |
GAB1 |
YLR459W |
Subunit of the glycosylphosphatidylinositol transamidase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SAC7 |
YDR389W |
GTPase activating protein (GAP) for Rho1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
COY1 |
YKL179C |
Golgi membrane protein with similarity to mammalian CASP |
genetic |
1 |
1 |
1 |
Positive Genetic |
RPL16B |
YNL069C |
Ribosomal 60S subunit protein L16B |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
YAP5 |
YIR018W |
Basic leucine zipper (bZIP) iron-sensing transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
ATP18 |
YML081C-A |
Subunit of the mitochondrial F1F0 ATP synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
EMP70 |
YLR083C |
Protein with a role in cellular adhesion and filamentous growth |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SRS2 |
YJL092W |
DNA helicase and DNA-dependent ATPase |
genetic |
1 |
1 |
1 |
Dosage Lethality |
GTB1 |
YDR221W |
Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
TIM21 |
YGR033C |
Nonessential component of the TIM23 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
ERG2 |
YMR202W |
C-8 sterol isomerase |
genetic |
1 |
1 |
1 |
Positive Genetic |
VMA21 |
YGR105W |
Integral membrane protein required for V-ATPase function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
CFD1 |
YIL003W |
Highly conserved iron-sulfur cluster binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
WBP1 |
YEL002C |
Beta subunit of the oligosaccharyl transferase glycoprotein complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SEC11 |
YIR022W |
18kDa catalytic subunit of the Signal Peptidase Complex (SPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RIM1 |
YCR028C-A |
ssDNA-binding protein essential for mitochondrial genome maintenance |
genetic |
1 |
1 |
1 |
Positive Genetic |
NGR1 |
YBR212W |
RNA binding protein that negatively regulates growth rate |
genetic |
1 |
1 |
1 |
Positive Genetic |
BPL1 |
YDL141W |
Biotin:apoprotein ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MSS4 |
YDR208W |
Phosphatidylinositol-4-phosphate 5-kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
PIP2 |
YOR363C |
Autoregulatory, oleate-activated transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
TRS23 |
YDR246W |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
1 |
1 |
1 |
Negative Genetic |
RAD30 |
YDR419W |
DNA polymerase eta |
genetic |
1 |
1 |
1 |
Positive Genetic |
TSA1 |
YML028W |
Thioredoxin peroxidase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
UBC8 |
YEL012W |
Ubiquitin-conjugating enzyme that regulates gluconeogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
GUK1 |
YDR454C |
Guanylate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
UBP2 |
YOR124C |
Ubiquitin-specific protease |
genetic |
1 |
1 |
1 |
Negative Genetic |
PMR1 |
YGL167C |
High affinity Ca2+/Mn2+ P-type ATPase |
genetic |
1 |
1 |
1 |
Positive Genetic |
ACB1 |
YGR037C |
Acyl-CoA-binding protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
TFG2 |
YGR005C |
TFIIF (Transcription Factor II) middle subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
PSD2 |
YGR170W |
Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes |
genetic |
1 |
1 |
1 |
Negative Genetic |
NOP19 |
YGR251W |
Ribosome biogenesis factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
YNG2 |
YHR090C |
Subunit of NuA4, an essential histone acetyltransferase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
GCD14 |
YJL125C |
Subunit of tRNA (1-methyladenosine) methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MUK1 |
YPL070W |
Guanine nucleotide exchange factor (GEF) |
physical |
1 |
1 |
1 |
Two-hybrid |
CTP1 |
YBR291C |
Mitochondrial inner membrane citrate transporter |
genetic |
1 |
1 |
1 |
Positive Genetic |
THP3 |
YPR045C |
Protein that may have a role in transcription elongation |
genetic |
1 |
1 |
1 |
Positive Genetic |
ELF1 |
YKL160W |
Transcription elongation factor with a conserved zinc finger domain |
genetic |
1 |
1 |
1 |
Positive Genetic |
RTT109 |
YLL002W |
Histone acetyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RIA1 |
YNL163C |
Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
YEF3 |
YLR249W |
Translation elongation factor 3 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ZUO1 |
YGR285C |
Ribosome-associated chaperone |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
YRM1 |
YOR172W |
Zinc finger transcription factor involved in multidrug resistance |
genetic |
1 |
1 |
1 |
Positive Genetic |
YTH1 |
YPR107C |
Essential RNA-binding component of cleavage and polyadenylation factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
YSA1 |
YBR111C |
Nudix hydrolase family member with ADP-ribose pyrophosphatase activity |
genetic |
1 |
1 |
1 |
Negative Genetic |
YUR1 |
YJL139C |
Mannosyltransferase involved in protein N-glycosylation |
genetic |
1 |
1 |
1 |
Negative Genetic |
ZWF1 |
YNL241C |
Glucose-6-phosphate dehydrogenase (G6PD) |
genetic |
1 |
1 |
1 |
Positive Genetic |
USA1 |
YML029W |
Scaffold subunit of the Hrd1p ubiquitin ligase |
genetic |
1 |
1 |
1 |
Positive Genetic |
NAM2 |
YLR382C |
Mitochondrial leucyl-tRNA synthetase |
genetic |
1 |
1 |
1 |
Positive Genetic |
COQ6 |
YGR255C |
Flavin-dependent monooxygenase involved in ubiquinone biosynthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
TPS3 |
YMR261C |
Regulatory subunit of trehalose-6-phosphate synthase/phosphatase |
genetic |
1 |
1 |
1 |
Positive Genetic |
DSF1 |
YEL070W |
Mannitol dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
ROT1 |
YMR200W |
Molecular chaperone involved in protein folding in ER |
genetic |
1 |
1 |
1 |
Negative Genetic |
UBP14 |
YBR058C |
Ubiquitin-specific protease |
genetic |
1 |
1 |
1 |
Negative Genetic |
GIS2 |
YNL255C |
Translational activator for mRNAs with internal ribosome entry sites |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
SGT2 |
YOR007C |
Glutamine-rich cytoplasmic cochaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
CUP9 |
YPL177C |
Homeodomain-containing transcriptional repressor |
genetic |
1 |
1 |
1 |
Negative Genetic |
JID1 |
YPR061C |
Probable Hsp40p co-chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
PHO13 |
YDL236W |
Conserved phosphatase acting as a metabolite repair enzyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
TIR4 |
YOR009W |
Cell wall mannoprotein |
genetic |
1 |
1 |
1 |
Negative Genetic |
TUB2 |
YFL037W |
Beta-tubulin |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
PTM1 |
YKL039W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
SEH1 |
YGL100W |
Subunit of the Nup84 nuclear pore and SEACAT subcomplexes |
genetic |
1 |
1 |
1 |
Positive Genetic |
RPL35A |
YDL191W |
Ribosomal 60S subunit protein L35A |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
NUP192 |
YJL039C |
Essential subunit of inner ring of nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Positive Genetic |
SLM3 |
YDL033C |
tRNA-specific 2-thiouridylase |
genetic |
1 |
1 |
1 |
Positive Genetic |
OCA5 |
YHL029C |
Cytoplasmic protein required for replication of Brome mosaic virus |
genetic |
1 |
1 |
1 |
Positive Genetic |
TSC13 |
YDL015C |
Enoyl reductase |
genetic |
1 |
1 |
1 |
Positive Genetic |
LDB7 |
YBL006C |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPL34B |
YIL052C |
Ribosomal 60S subunit protein L34B |
genetic |
1 |
1 |
1 |
Negative Genetic |
CAB1 |
YDR531W |
Pantothenate kinase, ATP:D-pantothenate 4'-phosphotransferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
DEG1 |
YFL001W |
tRNA:pseudouridine synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
AGE2 |
YIL044C |
ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector |
genetic |
1 |
1 |
1 |
Positive Genetic |
AST1 |
YBL069W |
Lipid raft associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
MSN4 |
YKL062W |
Stress-responsive transcriptional activator |
genetic |
1 |
1 |
1 |
Negative Genetic |
ENT4 |
YLL038C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
PIB2 |
YGL023C |
Phosphatidylinositol 3-phosphate binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
THP1 |
YOL072W |
Nuclear pore-associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
HUR1 |
YGL168W |
Protein with a role in DNA repair |
genetic |
1 |
1 |
1 |
Positive Genetic |
ERG24 |
YNL280C |
C-14 sterol reductase |
genetic |
1 |
1 |
1 |
Positive Genetic |
TYE7 |
YOR344C |
Serine-rich protein that contains a bHLH DNA binding motif |
genetic |
1 |
1 |
1 |
Negative Genetic |
DOT5 |
YIL010W |
Nuclear thiol peroxidase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SLM5 |
YCR024C |
Mitochondrial asparaginyl-tRNA synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
VPS27 |
YNR006W |
Endosomal protein that forms a complex with Hse1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
DER1 |
YBR201W |
ER membrane protein that promotes export of misfolded polypeptides |
genetic |
1 |
1 |
1 |
Positive Genetic |
SVP26 |
YHR181W |
ER exit adaptor for Golgi mannosyltransferases |
genetic |
1 |
1 |
1 |
Negative Genetic |
GSC2 |
YGR032W |
Catalytic subunit of 1,3-beta-glucan synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
ALO1 |
YML086C |
D-Arabinono-1,4-lactone oxidase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SSM4 |
YIL030C |
Membrane-embedded ubiquitin-protein ligase and retrotranslocase |
physical |
1 |
1 |
1 |
Protein-peptide |
EST2 |
YLR318W |
Reverse transcriptase subunit of the telomerase holoenzyme |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
TED1 |
YIL039W |
GPI-glycan remodelase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
EAR1 |
YMR171C |
Specificity factor required for Rsp5p-dependent ubiquitination |
genetic |
1 |
1 |
1 |
Negative Genetic |
NPR1 |
YNL183C |
Protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
NCB2 |
YDR397C |
Subunit of a heterodimeric NC2 transcription regulator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
TIM54 |
YJL054W |
Component of the mitochondrial TIM22 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SUR7 |
YML052W |
Plasma membrane protein, component of eisosomes |
genetic |
1 |
1 |
1 |
Negative Genetic |
SLG1 |
YOR008C |
Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway |
genetic |
1 |
1 |
1 |
Positive Genetic |
SDD4 |
YPR022C |
Putative transcription factor, as suggested by computational analysis |
genetic |
1 |
1 |
1 |
Negative Genetic |
ERG4 |
YGL012W |
C-24(28) sterol reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
AIM34 |
YMR003W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
ALG14 |
YBR070C |
Component of UDP-GlcNAc transferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SHR3 |
YDL212W |
Endoplasmic reticulum packaging chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
ALG7 |
YBR243C |
UDP-N-acetyl-glucosamine-1-P transferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
TMH11 |
YJR085C |
Mitochondrial protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
PIN2 |
YOR104W |
Exomer-dependent cargo protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
KRE9 |
YJL174W |
Glycoprotein involved in cell wall beta-glucan assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
TCD1 |
YHR003C |
tRNA threonylcarbamoyladenosine dehydratase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SQT1 |
YIR012W |
Specific assembly chaperone for ribosomal protein Rpl10p |
genetic |
1 |
1 |
1 |
Positive Genetic |
VPS24 |
YKL041W |
One of four subunits of the ESCRT-III complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
KRE1 |
YNL322C |
Cell wall glycoprotein involved in beta-glucan assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
MAK31 |
YCR020C-A |
Non-catalytic subunit of N-terminal acetyltransferase of the NatC type |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
PFA4 |
YOL003C |
Palmitoyltransferase with autoacylation activity |
genetic |
1 |
1 |
1 |
Negative Genetic |
CCW14 |
YLR390W-A |
Covalently linked cell wall glycoprotein |
genetic |
1 |
1 |
1 |
Positive Genetic |
GPI18 |
YBR004C |
Functional ortholog of human PIG-V |
genetic |
1 |
1 |
1 |
Negative Genetic |
STE24 |
YJR117W |
Highly conserved zinc metalloprotease |
genetic |
1 |
1 |
1 |
Negative Genetic |
VTS1 |
YOR359W |
Flap-structured DNA-binding and RNA-binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
SED4 |
YCR067C |
Integral ER membrane protein that stimulates Sar1p GTPase activity |
genetic |
1 |
1 |
1 |
Negative Genetic |
MET13 |
YGL125W |
Major isozyme of methylenetetrahydrofolate reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPH1 |
YER169W |
JmjC domain-containing histone demethylase |
genetic |
1 |
1 |
1 |
Positive Genetic |
SAM37 |
YMR060C |
Component of the Sorting and Assembly Machinery (SAM) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
JAC1 |
YGL018C |
Specialized J-protein that functions in Fe-S cluster biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
ERG9 |
YHR190W |
Farnesyl-diphosphate farnesyl transferase (squalene synthase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
ERD1 |
YDR414C |
Predicted membrane protein required for lumenal ER protein retention |
genetic |
1 |
1 |
1 |
Positive Genetic |
NAT4 |
YMR069W |
N alpha-acetyl-transferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
FMC1 |
YIL098C |
Mitochondrial matrix protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
MCP1 |
YOR228C |
Mitochondrial protein of unknown function involved in lipid homeostas |
genetic |
1 |
1 |
1 |
Negative Genetic |
CRD1 |
YDL142C |
Cardiolipin synthase |
genetic |
1 |
1 |
1 |
Positive Genetic |
MAL33 |
YBR297W |
MAL-activator protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
AIM20 |
YIL158W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
COX16 |
YJL003W |
Mitochondrial inner membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
ALE1 |
YOR175C |
Broad-specificity lysophospholipid acyltransferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
FMP30 |
YPL103C |
Protein with a role in maintaining mitochondrial morphology |
genetic |
1 |
1 |
1 |
Negative Genetic |
DFR1 |
YOR236W |
Dihydrofolate reductase involved in tetrahydrofolate biosynthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
ALG11 |
YNL048W |
Alpha-1,2-mannosyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
PMP3 |
YDR276C |
Small plasma membrane protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
TMN2 |
YDR107C |
Protein with a role in cellular adhesion and filamentous growth |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
VAC7 |
YNL054W |
Integral vacuolar membrane protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
SPT14 |
YPL175W |
UDP-glycosyltransferase subunit of the GPI-GnT complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
PER1 |
YCR044C |
Protein of the endoplasmic reticulum |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MMM1 |
YLL006W |
ER integral membrane protein, ERMES complex subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
PKP1 |
YIL042C |
Mitochondrial protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
TAX4 |
YJL083W |
EH domain-containing protein |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
MGR2 |
YPL098C |
Subunit of the TIM23 translocase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
YPT10 |
YBR264C |
Rab family GTP-binding protein |
physical |
1 |
1 |
1 |
Two-hybrid |
SCS3 |
YGL126W |
Protein required for normal ER membrane biosynthesis in response to ER |
genetic |
1 |
1 |
1 |
Negative Genetic |
YET3 |
YDL072C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YPT31 |
YER031C |
Rab family GTPase |
genetic |
1 |
1 |
1 |
Positive Genetic |
VID22 |
YLR373C |
G-quadruplex (G4) DNA binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
EMP65 |
YER140W |
Integral membrane protein of the ER |
genetic |
1 |
1 |
1 |
Negative Genetic |
ECM14 |
YHR132C |
Conserved fungal protein with similarity to zinc carboxypeptidases |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPP41 |
YDR464W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
UBR2 |
YLR024C |
Cytoplasmic ubiquitin-protein ligase (E3) |
genetic |
1 |
1 |
1 |
Positive Genetic |
IRC21 |
YMR073C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
UBP13 |
YBL067C |
Ubiquitin-specific protease that cleaves Ub-protein fusions |
genetic |
1 |
1 |
1 |
Negative Genetic |
SEN34 |
YAR008W |
Subunit of the tRNA splicing endonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
RBH1 |
YJL181W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
MTC4 |
YBR255W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
THR4 |
YCR053W |
Threonine synthase |
genetic |
1 |
1 |
1 |
Positive Genetic |
UPC2 |
YDR213W |
Sterol regulatory element binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPF1 |
YEL031W |
P-type ATPase, ion transporter of the ER membrane |
genetic |
1 |
1 |
1 |
Negative Genetic |
UGA3 |
YDL170W |
Transcriptional activator for GABA-dependent induction of GABA genes |
genetic |
1 |
1 |
1 |
Negative Genetic |
SSP2 |
YOR242C |
Sporulation specific protein that localizes to the spore wall |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPO24 |
YPR036W-A |
Small (67 amino acids) protein involved in sporulation |
genetic |
1 |
1 |
1 |
Negative Genetic |
YPR084W |
YPR084W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SYC1 |
YOR179C |
Subunit of the APT subcomplex of cleavage and polyadenylation factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
VPH2 |
YKL119C |
Integral membrane protein required for V-ATPase function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YBL036C |
YBL036C |
Putative non-specific single-domain racemase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MTC6 |
YHR151C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
YPL113C |
YPL113C |
Glyoxylate reductase |
genetic |
1 |
1 |
1 |
Positive Genetic |
PAU2 |
YEL049W |
Member of the seripauperin multigene family |
genetic |
1 |
1 |
1 |
Negative Genetic |
ECM23 |
YPL021W |
Non-essential protein of unconfirmed function |
genetic |
1 |
1 |
1 |
Negative Genetic |
TUF1 |
YOR187W |
Mitochondrial translation elongation factor Tu (EF-Tu) |
genetic |
1 |
1 |
1 |
Positive Genetic |
TRL1 |
YJL087C |
tRNA ligase |
genetic |
1 |
1 |
1 |
Positive Genetic |
TEP1 |
YNL128W |
PTEN homolog with no demonstrated inositol lipid phosphatase activity |
genetic |
1 |
1 |
1 |
Negative Genetic |
MNL2 |
YLR057W |
Putative mannosidase involved in ER-associated protein degradation |
genetic |
1 |
1 |
1 |
Negative Genetic |
YDL180W |
YDL180W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
TMN3 |
YER113C |
Protein with a role in cellular adhesion and filamentous growth |
genetic |
1 |
1 |
1 |
Negative Genetic |
YPT32 |
YGL210W |
Rab family GTPase involved in the exocytic pathway |
genetic |
1 |
1 |
1 |
Positive Genetic |
YML119W |
YML119W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YBR287W |
YBR287W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YHR078W |
YHR078W |
High osmolarity-regulated gene of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YKL063C |
YKL063C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YMR160W |
YMR160W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
YPK9 |
YOR291W |
Vacuolar protein with a possible role in sequestering heavy metals |
genetic |
1 |
1 |
1 |
Negative Genetic |
YPR114W |
YPR114W |
Protein distantly similar to ceramide synthases, Lag1p and Lac1p |
genetic |
1 |
1 |
1 |
Positive Genetic |
YER079W |
YER079W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YER085C |
YER085C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YJR011C |
YJR011C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
YOR008C-A |
YOR008C-A |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YDR524W-C |
YDR524W-C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YGL188C-A |
YGL188C-A |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YGR018C |
YGR018C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YNR021W |
YNR021W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YMR196W |
YMR196W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YNR068C |
YNR068C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |