Standard name Systematic name Name description Description
SEN2 YLR105C Subunit of the tRNA splicing endonuclease Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial surface; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease;
Visualize the interactome of SEN2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.199 0.20 0.395
Endosome 0.079 NaN NaN
Mito 0.732 0.78 0.311
Vac/Vac Memb 0.096 0.06 0.079
Cort. Patches NaN 0.06 NaN
ER NaN 0.10 NaN
SpindlePole NaN NaN 0.158

GFP localization & abundance

GFP localization GFP abundance
mitochondrion 319

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SEN2 3 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SEN54 YPL083C Subunit of the tRNA splicing endonuclease physical 3 3 3 Two-hybrid, Co-fractionation, Affinity Capture-Western
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 2 2 2 Synthetic Lethality, Positive Genetic
SEN15 YMR059W Subunit of the tRNA splicing endonuclease physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
SEN34 YAR008W Subunit of the tRNA splicing endonuclease physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
TOM70 YNL121C Component of the TOM (translocase of outer membrane) complex genetic 2 1 1 Negative Genetic, Negative Genetic
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UGA3 YDL170W Transcriptional activator for GABA-dependent induction of GABA genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Synthetic Lethality
AIM25 YJR100C Mitochondria protein of unknown function genetic 1 1 1 Negative Genetic
PSF2 YJL072C Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 1 1 1 Negative Genetic
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 1 1 1 Negative Genetic
PEX7 YDR142C Peroxisomal signal receptor for peroxisomal matrix proteins physical 1 1 1 Affinity Capture-MS
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein physical 1 1 1 Affinity Capture-RNA
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 1 1 1 Negative Genetic
HCR1 YLR192C eIF3j component of translation initiation factor 3 (eIF3) genetic 1 1 1 Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
PRE7 YBL041W Beta 6 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
BUD20 YLR074C C2H2-type zinc finger protein required for ribosome assembly genetic 1 1 1 Positive Genetic
ATP11 YNL315C Molecular chaperone genetic 1 1 1 Negative Genetic
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease genetic 1 1 1 Negative Genetic
DYN1 YKR054C Cytoplasmic heavy chain dynein physical 1 1 1 Two-hybrid
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
HRP1 YOL123W Subunit of cleavage factor I genetic 1 1 1 Negative Genetic
KIN3 YAR018C Nonessential serine/threonine protein kinase physical 1 1 1 Two-hybrid
IMG2 YCR071C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
PRP4 YPR178W Splicing factor genetic 1 1 1 Negative Genetic
DAM1 YGR113W Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
NUP120 YKL057C Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
RPP2B YDR382W Ribosomal protein P2 beta genetic 1 1 1 Negative Genetic
CCT2 YIL142W Subunit beta of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
BZZ1 YHR114W SH3 domain protein implicated in regulating actin polymerization physical 1 1 1 Two-hybrid
PRP18 YGR006W Splicing factor and component of snRNP U5 genetic 1 1 1 Negative Genetic
PRP38 YGR075C Unique component of the U4/U6.U5 tri-snRNP particle genetic 1 1 1 Negative Genetic
CMK1 YFR014C Calmodulin-dependent protein kinase genetic 1 1 1 Negative Genetic
SEN15 YMR059W Subunit of the tRNA splicing endonuclease genetic 1 1 1 Negative Genetic
KIN28 YDL108W Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly genetic 1 1 1 Negative Genetic
PTP2 YOR208W Phosphotyrosine-specific phosphatase genetic 1 1 1 Negative Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Positive Genetic
MGT1 YDL200C DNA repair methyltransferase (6-O-methylguanine-DNA methylase) genetic 1 1 1 Negative Genetic
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 1 1 1 Negative Genetic
NAS2 YIL007C Evolutionarily conserved 19S regulatory particle assembly-chaperone genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
NDL1 YLR254C Homolog of nuclear distribution factor NudE physical 1 1 1 Two-hybrid
CEP3 YMR168C Essential kinetochore protein genetic 1 1 1 Negative Genetic
MCM1 YMR043W Transcription factor genetic 1 1 1 Positive Genetic
RPS1B YML063W Ribosomal protein of the small (40S) subunit genetic 1 1 1 Negative Genetic
ELO2 YCR034W Fatty acid elongase, involved in sphingolipid biosynthesis genetic 1 1 1 Negative Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
ECM27 YJR106W Protein involved in calcium homeostasis and exit from quiescence genetic 1 1 1 Negative Genetic
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Negative Genetic
SLF1 YDR515W RNA binding protein that associates with polysomes physical 1 1 1 Affinity Capture-RNA
TYE7 YOR344C Serine-rich protein that contains a bHLH DNA binding motif physical 1 1 1 Two-hybrid
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) physical 1 1 1 Affinity Capture-Western
SLS1 YLR139C Mitochondrial membrane protein genetic 1 1 1 Negative Genetic
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Negative Genetic
TUF1 YOR187W Mitochondrial translation elongation factor Tu (EF-Tu) genetic 1 1 1 Negative Genetic
YHL042W YHL042W Endoplasmic reticulum protein genetic 1 1 1 Positive Genetic
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p genetic 1 1 1 Negative Genetic
YDL186W YDL186W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YKL063C YKL063C Putative protein of unknown function genetic 1 1 1 Negative Genetic
VPS501 YKR078W Vacuolar SNX-BAR protein genetic 1 1 1 Negative Genetic
TSR2 YLR435W Protein with a potential role in pre-rRNA processing genetic 1 1 1 Negative Genetic
SER1 YOR184W 3-phosphoserine aminotransferase genetic 1 1 1 Negative Genetic
TGS1 YPL157W Trimethyl guanosine synthase, conserved nucleolar methyl transferase genetic 1 1 1 Negative Genetic
YPR097W YPR097W Protein that contains a PX domain and binds phosphoinositides genetic 1 1 1 Negative Genetic
PBP1 YGR178C Component of glucose deprivation induced stress granules genetic 1 1 1 Negative Genetic
NIP100 YPL174C Large subunit of the dynactin complex physical 1 1 1 Two-hybrid
POG1 YIL122W DNA-binding transcriptional activator genetic 1 1 1 Negative Genetic
GEF1 YJR040W Voltage-gated chloride channel genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
FMP46 YKR049C Putative redox protein containing a thioredoxin fold genetic 1 1 1 Negative Genetic
RPS25B YLR333C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-RNA
RPS16A YMR143W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
COQ2 YNR041C Para hydroxybenzoate polyprenyl transferase genetic 1 1 1 Positive Genetic
MDM34 YGL219C Mitochondrial component of the ERMES complex genetic 1 1 1 Negative Genetic
SAD1 YFR005C Conserved zinc-finger domain protein involved in pre-mRNA splicing genetic 1 1 1 Negative Genetic
PXP1 YEL020C Peroxisomal matrix protein genetic 1 1 1 Negative Genetic
DIT1 YDR403W Sporulation-specific enzyme required for spore wall maturation genetic 1 1 1 Negative Genetic
NCS6 YGL211W Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs genetic 1 1 1 Negative Genetic
RIB2 YOL066C Bifunctional DRAP deaminase tRNA:pseudouridine synthase genetic 1 1 1 Negative Genetic