Standard name Systematic name Name description Description
NCS6 YGL211W Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs; required for the thiolation of uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
Visualize the interactome of NCS6
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cort. Patches 0.117 0.174 0.188
Endosome 0.309 0.197 0.362
Golgi 0.415 0.449 0.536
Mito 0.372 0.309 NaN
Vac/Vac Memb 0.085 0.124 0.087
Cytoplasm NaN 0.073 NaN
ER NaN 0.073 NaN
SpindlePole NaN NaN 0.087

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
NCS6 6 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 5 2 4 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
IKI3 YLR384C Subunit of Elongator complex genetic 5 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GET2 YER083C Subunit of the GET complex genetic 5 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 4 2 3 Negative Genetic, Negative Genetic, Negative Genetic, Dosage Rescue
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 4 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 4 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ELP6 YMR312W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
SRN2 YLR119W Component of the ESCRT-I complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
GET1 YGL020C Subunit of the GET complex genetic 3 2 2 Negative Genetic, Negative Genetic, Synthetic Growth Defect
PFY1 YOR122C Profilin genetic 3 2 2 Synthetic Growth Defect, Negative Genetic, Negative Genetic
BRE1 YDL074C E3 ubiquitin ligase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
GYP1 YOR070C Cis-golgi GTPase-activating protein (GAP) for yeast Rabs genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
AIM44 YPL158C Regulator of Cdc42p and Rho1p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
DEG1 YFL001W tRNA:pseudouridine synthase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
UBA4 YHR111W E1-like protein that activates Urm1p before urmylation genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPL35B YDL136W Ribosomal 60S subunit protein L35B genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
TEF2 YBR118W Translational elongation factor EF-1 alpha genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
TCD1 YHR003C tRNA threonylcarbamoyladenosine dehydratase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
TCD2 YKL027W tRNA threonylcarbamoyladenosine dehydratase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPL8B YLL045C Ribosomal 60S subunit protein L8A genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
TMA23 YMR269W Nucleolar protein implicated in ribosome biogenesis genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
NOC3 YLR002C Subunit of a nuclear complex with Noc2p and pre-replicative complexes genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SEC63 YOR254C Essential subunit of Sec63 complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HMI1 YOL095C Mitochondrial inner membrane localized ATP-dependent DNA helicase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
NCS2 YNL119W Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs physical 3 2 1 Two-hybrid, Two-hybrid, Affinity Capture-MS
URM1 YIL008W Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs physical 3 2 1 Two-hybrid, Affinity Capture-MS, Affinity Capture-MS
CDC42 YLR229C Small rho-like GTPase genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
BIM1 YER016W Microtubule plus end-tracking protein genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
ELP3 YPL086C Subunit of Elongator complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
ELP4 YPL101W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CDC10 YCR002C Component of the septin ring, required for cytokinesis genetic 2 1 2 Negative Genetic, Negative Genetic
BNI1 YNL271C Formin genetic 2 1 2 Negative Genetic, Negative Genetic
MED2 YDL005C Subunit of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 2 1 2 Negative Genetic, Negative Genetic
BNI4 YNL233W Targeting subunit for Glc7p protein phosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
KTI12 YKL110C Protein that plays a role in modification of tRNA wobble nucleosides genetic 2 1 2 Negative Genetic, Negative Genetic
IKI1 YHR187W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 2 1 2 Negative Genetic, Negative Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
CIN2 YPL241C GTPase-activating protein (GAP) for Cin4p genetic 2 1 2 Negative Genetic, Negative Genetic
NCS2 YNL119W Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs genetic 2 1 2 Positive Genetic, Positive Genetic
RRP1 YDR087C Essential evolutionarily conserved nucleolar protein genetic 2 1 2 Negative Genetic, Negative Genetic
PDB1 YBR221C E1 beta subunit of the pyruvate dehydrogenase (PDH) complex genetic 2 1 2 Negative Genetic, Negative Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 2 1 2 Negative Genetic, Negative Genetic
YJL132W YJL132W Putative protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
SKY1 YMR216C SR protein kinase (SRPK) genetic 2 1 2 Negative Genetic, Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 2 1 2 Negative Genetic, Negative Genetic
TRM11 YOL124C Catalytic subunit of adoMet-dependent tRNA methyltransferase complex genetic 2 1 2 Negative Genetic, Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 2 1 2 Negative Genetic, Negative Genetic
VPS21 YOR089C Endosomal Rab family GTPase genetic 2 1 2 Negative Genetic, Negative Genetic
VPS20 YMR077C Myristoylated subunit of the ESCRT-III complex genetic 2 1 2 Negative Genetic, Negative Genetic
VPS28 YPL065W Component of the ESCRT-I complex genetic 2 1 2 Negative Genetic, Negative Genetic
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 2 1 2 Negative Genetic, Negative Genetic
GPI1 YGR216C Membrane protein involved in the synthesis of GlcNAc-PI genetic 2 1 2 Negative Genetic, Negative Genetic
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 2 1 2 Negative Genetic, Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 2 1 1 Negative Genetic, Negative Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 2 1 1 Negative Genetic, Negative Genetic
ELP2 YGR200C Subunit of Elongator complex genetic 2 1 1 Negative Genetic, Negative Genetic
GET3 YDL100C Guanine nucleotide exchange factor for Gpa1p genetic 2 1 1 Negative Genetic, Negative Genetic
CIK1 YMR198W Kinesin-associated protein genetic 2 1 1 Positive Genetic, Positive Genetic
MMR1 YLR190W Phosphorylated protein of the mitochondrial outer membrane genetic 2 1 1 Positive Genetic, Positive Genetic
DPM1 YPR183W Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane genetic 2 1 1 Negative Genetic, Negative Genetic
GLN4 YOR168W Glutamine tRNA synthetase genetic 2 1 1 Negative Genetic, Negative Genetic
MPS3 YJL019W Nuclear envelope protein genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
UBA4 YHR111W E1-like protein that activates Urm1p before urmylation physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
RPS11B YBR048W Protein component of the small (40S) ribosomal subunit genetic 2 1 1 Negative Genetic, Negative Genetic
PCA1 YBR295W Cadmium transporting P-type ATPase genetic 2 1 1 Negative Genetic, Negative Genetic
RPS25A YGR027C Protein component of the small (40S) ribosomal subunit genetic 2 1 1 Negative Genetic, Negative Genetic
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
TPM2 YIL138C Minor isoform of tropomyosin genetic 2 1 1 Negative Genetic, Negative Genetic
NHP2 YDL208W Protein related to mammalian high mobility group (HMG) proteins genetic 2 1 1 Negative Genetic, Negative Genetic
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 2 1 1 Negative Genetic, Negative Genetic
RRP4 YHR069C Exosome non-catalytic core component genetic 2 1 1 Negative Genetic, Negative Genetic
SSC1 YJR045C Hsp70 family ATPase genetic 2 1 1 Negative Genetic, Negative Genetic
SEC61 YLR378C Conserved ER protein translocation channel genetic 2 1 1 Negative Genetic, Negative Genetic
SEC39 YLR440C Component of the Dsl1p tethering complex genetic 2 1 1 Negative Genetic, Negative Genetic
VTI1 YMR197C Protein involved in cis-Golgi membrane traffic genetic 2 1 1 Negative Genetic, Negative Genetic
RPC34 YNR003C RNA polymerase III subunit C34 genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription genetic 1 1 1 Positive Genetic
GWT1 YJL091C Protein involved in the inositol acylation of GlcN-PI genetic 1 1 1 Negative Genetic
BRX1 YOL077C Nucleolar protein genetic 1 1 1 Negative Genetic
MTR4 YJL050W RNA duplex-sensing translocase genetic 1 1 1 Negative Genetic
LSM3 YLR438C-A Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity genetic 1 1 1 Negative Genetic
CSL4 YNL232W Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
LRP1 YHR081W Nuclear exosome-associated nucleic acid binding protein genetic 1 1 1 Negative Genetic
NAP1 YKR048C Histone chaperone and assembly chaperone for Rps6a/b genetic 1 1 1 Negative Genetic
GCD1 YOR260W Gamma subunit of the translation initiation factor eIF2B genetic 1 1 1 Negative Genetic
GCD2 YGR083C Delta subunit of the translation initiation factor eIF2B genetic 1 1 1 Negative Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
BEM1 YBR200W Protein containing SH3-domains genetic 1 1 1 Negative Genetic
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 1 1 1 Negative Genetic
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
ATP11 YNL315C Molecular chaperone genetic 1 1 1 Positive Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 1 1 1 Negative Genetic
COX6 YHR051W Subunit VI of cytochrome c oxidase (Complex IV) genetic 1 1 1 Positive Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Negative Genetic
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Positive Genetic
GCN2 YDR283C Protein kinase genetic 1 1 1 Synthetic Rescue
GDI1 YER136W GDP dissociation inhibitor genetic 1 1 1 Negative Genetic
GLO3 YER122C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 1 1 1 Positive Genetic
KRR1 YCL059C Nucleolar protein required for rRNA synthesis and ribosomal assembly genetic 1 1 1 Negative Genetic
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
LSM7 YNL147W Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
MOT1 YPL082C Essential protein involved in regulation of transcription genetic 1 1 1 Negative Genetic
HRR25 YPL204W Conserved casein kinase, monopolin subunit genetic 1 1 1 Negative Genetic
IMG2 YCR071C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
CMD1 YBR109C Calmodulin genetic 1 1 1 Negative Genetic
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
FPR4 YLR449W Peptidyl-prolyl cis-trans isomerase (PPIase) genetic 1 1 1 Negative Genetic
AFG2 YLR397C ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex genetic 1 1 1 Negative Genetic
MED8 YBR193C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
ANP1 YEL036C Subunit of the alpha-1,6 mannosyltransferase complex genetic 1 1 1 Negative Genetic
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Negative Genetic
GSP2 YOR185C GTP binding protein (mammalian Ranp homolog) genetic 1 1 1 Negative Genetic
KOG1 YHR186C Subunit of TORC1 genetic 1 1 1 Negative Genetic
ERG27 YLR100W 3-keto sterol reductase genetic 1 1 1 Negative Genetic
CDC60 YPL160W Cytosolic leucyl tRNA synthetase genetic 1 1 1 Positive Genetic
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation physical 1 1 1 Affinity Capture-MS
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 1 1 1 Synthetic Growth Defect
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) genetic 1 1 1 Negative Genetic
FPK1 YNR047W Ser/Thr protein kinase physical 1 1 1 Biochemical Activity
FAL1 YDR021W Nucleolar protein required for maturation of 18S rRNA genetic 1 1 1 Negative Genetic
FCF1 YDR339C PINc domain endonuclease genetic 1 1 1 Negative Genetic
CMG1 YLR271W Putative protein of unknown function genetic 1 1 1 Negative Genetic
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Negative Genetic
DHR2 YKL078W Predominantly nucleolar DEAH-box ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) physical 1 1 1 Protein-peptide
ENT3 YJR125C Protein containing an N-terminal epsin-like domain genetic 1 1 1 Negative Genetic
GCN4 YEL009C bZIP transcriptional activator of amino acid biosynthetic genes genetic 1 1 1 Synthetic Rescue
NBA1 YOL070C Protein involved in axial bud site selection genetic 1 1 1 Negative Genetic
MDY2 YOL111C Protein involved in inserting tail-anchored proteins into ER membranes genetic 1 1 1 Negative Genetic
COG4 YPR105C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
COG5 YNL051W Component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
CET1 YPL228W RNA 5'-triphosphatase involved in mRNA 5' capping genetic 1 1 1 Negative Genetic
HPC2 YBR215W Subunit of the HIR complex genetic 1 1 1 Negative Genetic
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 1 1 1 Negative Genetic
ATG8 YBL078C Ub-like protein genetic 1 1 1 Negative Genetic
CLC1 YGR167W Clathrin light chain genetic 1 1 1 Negative Genetic
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 1 1 1 Negative Genetic
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Synthetic Growth Defect
BET1 YIL004C Type II membrane protein required for vesicular transport genetic 1 1 1 Negative Genetic
ERV41 YML067C Protein localized to COPII-coated vesicles genetic 1 1 1 Negative Genetic
MGM1 YOR211C Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p genetic 1 1 1 Negative Genetic
GOS1 YHL031C v-SNARE protein involved in Golgi transport genetic 1 1 1 Negative Genetic
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system genetic 1 1 1 Negative Genetic
HAP4 YKL109W Transcription factor genetic 1 1 1 Negative Genetic
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
FCP1 YMR277W Carboxy-terminal domain (CTD) phosphatase genetic 1 1 1 Negative Genetic
AKR1 YDR264C Palmitoyl transferase involved in protein palmitoylation genetic 1 1 1 Negative Genetic
HFM1 YGL251C Meiosis specific DNA helicase genetic 1 1 1 Dosage Rescue
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Negative Genetic
EIS1 YMR031C Component of the eisosome required for proper eisosome assembly genetic 1 1 1 Negative Genetic
BET4 YJL031C Alpha subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 1 1 1 Negative Genetic
FRA1 YLL029W Protein involved in negative regulation of iron regulon transcription genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
GUK1 YDR454C Guanylate kinase genetic 1 1 1 Negative Genetic
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
MTC1 YJL123C Protein of unknown function that may interact with ribosomes genetic 1 1 1 Negative Genetic
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-RNA
HEM12 YDR047W Uroporphyrinogen decarboxylase genetic 1 1 1 Positive Genetic
DPH5 YLR172C Methyltransferase required for synthesis of diphthamide genetic 1 1 1 Negative Genetic
ERG24 YNL280C C-14 sterol reductase genetic 1 1 1 Positive Genetic
GPI19 YDR437W Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
NCB2 YDR397C Subunit of a heterodimeric NC2 transcription regulator complex genetic 1 1 1 Negative Genetic
ALG14 YBR070C Component of UDP-GlcNAc transferase genetic 1 1 1 Negative Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Negative Genetic
MLO127 YJR039W Mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
FLO1 YAR050W Lectin-like protein involved in flocculation genetic 1 1 1 Negative Genetic
TUM1 YOR251C Rhodanese domain sulfur transferase physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein physical 1 1 1 Affinity Capture-MS
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 1 1 1 Synthetic Growth Defect
TRM9 YML014W tRNA methyltransferase genetic 1 1 1 Synthetic Growth Defect
SEC14 YMR079W Phosphatidylinositol/phosphatidylcholine transfer protein genetic 1 1 1 Synthetic Growth Defect
PDI1 YCL043C Protein disulfide isomerase genetic 1 1 1 Synthetic Lethality
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Negative Genetic
PYC2 YBR218C Pyruvate carboxylase isoform genetic 1 1 1 Negative Genetic
RPS16B YDL083C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPP1A YDL081C Ribosomal stalk protein P1 alpha genetic 1 1 1 Negative Genetic
RXT3 YDL076C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
PKH1 YDR490C Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
YGL036W YGL036W Putative protein of unknown function genetic 1 1 1 Negative Genetic
STB5 YHR178W Transcription factor genetic 1 1 1 Positive Genetic
YKL069W YKL069W Methionine-R-sulfoxide reductase genetic 1 1 1 Negative Genetic
TOR1 YJR066W PIK-related protein kinase and rapamycin target genetic 1 1 1 Synthetic Growth Defect
UTR1 YJR049C ATP-NADH kinase genetic 1 1 1 Positive Genetic
TAF8 YML114C TFIID subunit (65 kDa) genetic 1 1 1 Negative Genetic
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 1 1 1 Negative Genetic
RIA1 YNL163C Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis genetic 1 1 1 Positive Genetic
PRP4 YPR178W Splicing factor genetic 1 1 1 Negative Genetic
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Synthetic Growth Defect
VOA1 YGR106C ER protein that functions in assembly of the V0 sector of V-ATPase genetic 1 1 1 Synthetic Growth Defect
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Positive Genetic
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer genetic 1 1 1 Positive Genetic
TAH11 YJR046W DNA replication licensing factor genetic 1 1 1 Positive Genetic
PGA2 YNL149C Essential protein required for maturation of Gas1p and Pho8p genetic 1 1 1 Positive Genetic
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Positive Genetic
SEC2 YNL272C Guanyl-nucleotide exchange factor for the small G-protein Sec4p genetic 1 1 1 Positive Genetic
RPB10 YOR210W RNA polymerase subunit ABC10-beta genetic 1 1 1 Positive Genetic
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Positive Genetic
SFB3 YHR098C Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat genetic 1 1 1 Positive Genetic
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 1 1 1 Positive Genetic
QCR8 YJL166W Subunit 8 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Positive Genetic
RPA49 YNL248C RNA polymerase I subunit A49 genetic 1 1 1 Positive Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Negative Genetic
RER2 YBR002C Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1 genetic 1 1 1 Negative Genetic
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes genetic 1 1 1 Negative Genetic
NUS1 YDL193W Forms dehydrodolichyl diphosphate synthase complex with RER2 or SRT1 genetic 1 1 1 Negative Genetic
SLY1 YDR189W Hydrophilic protein involved in ER/Golgi vesicle trafficking genetic 1 1 1 Negative Genetic
TLG1 YDR468C Essential t-SNARE that mediates fusion of vesicles with the late Golgi genetic 1 1 1 Negative Genetic
SEC20 YDR498C Membrane glycoprotein v-SNARE genetic 1 1 1 Negative Genetic
RBA50 YDR527W Protein involved in transcription genetic 1 1 1 Negative Genetic
POL5 YEL055C Protein involved in 60S assembly and pre-40S AFs recycling genetic 1 1 1 Negative Genetic
PMI40 YER003C Mannose-6-phosphate isomerase genetic 1 1 1 Negative Genetic
PRE1 YER012W Beta 4 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
SPB4 YFL002C Putative ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
PTI1 YGR156W Essential component of CPF (cleavage and polyadenylation factor) genetic 1 1 1 Negative Genetic
ZPR1 YGR211W Essential protein with two zinc fingers genetic 1 1 1 Negative Genetic
YKT6 YKL196C Vesicle membrane protein (v-SNARE) with acyltransferase activity genetic 1 1 1 Negative Genetic
SEN2 YLR105C Subunit of the tRNA splicing endonuclease genetic 1 1 1 Negative Genetic
YHC1 YLR298C Component of the U1 snRNP complex required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
RPP0 YLR340W Conserved ribosomal protein P0 of the ribosomal stalk genetic 1 1 1 Negative Genetic
TAF13 YML098W TFIID subunit (19 kDa) genetic 1 1 1 Negative Genetic
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
PRP24 YMR268C Splicing factor that reanneals snRNPs during spliceosome recycling genetic 1 1 1 Negative Genetic
TOP2 YNL088W Topoisomerase II genetic 1 1 1 Negative Genetic
YTM1 YOR272W Ribosomal assembly factor and 66S pre-ribosomal particle constituent genetic 1 1 1 Negative Genetic
NOG1 YPL093W Putative GTPase genetic 1 1 1 Negative Genetic
SUI3 YPL237W Beta subunit of the translation initiation factor eIF2 genetic 1 1 1 Negative Genetic
SEC17 YBL050W Alpha-SNAP cochaperone genetic 1 1 1 Negative Genetic
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 1 1 1 Negative Genetic
SUP35 YDR172W Translation termination factor eRF3 genetic 1 1 1 Negative Genetic
SPC110 YDR356W Inner plaque spindle pole body (SPB) component genetic 1 1 1 Negative Genetic
SYF1 YDR416W Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
PUP3 YER094C Beta 3 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
RPF1 YHR088W Protein involved in assembly and export of the large ribosomal subunit genetic 1 1 1 Negative Genetic
SED5 YLR026C cis-Golgi t-SNARE syntaxin genetic 1 1 1 Negative Genetic
NOP56 YLR197W Essential evolutionarily-conserved nucleolar protein genetic 1 1 1 Negative Genetic
RPB2 YOR151C RNA polymerase II second largest subunit B150 genetic 1 1 1 Negative Genetic
SEC62 YPL094C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Negative Genetic
STP22 YCL008C Component of the ESCRT-I complex genetic 1 1 1 Negative Genetic
SAC6 YDR129C Fimbrin, actin-bundling protein genetic 1 1 1 Negative Genetic
PUF6 YDR496C Pumilio-homology domain protein genetic 1 1 1 Negative Genetic
STL1 YDR536W Glycerol proton symporter of the plasma membrane genetic 1 1 1 Negative Genetic
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 1 1 1 Negative Genetic
YBR287W YBR287W Protein of unknown function genetic 1 1 1 Negative Genetic
YCL002C YCL002C Putative protein of unknown function genetic 1 1 1 Negative Genetic
RBK1 YCR036W Ribokinase, phosphorylates ribose to ribose-5-phosphate genetic 1 1 1 Negative Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Negative Genetic
SLM3 YDL033C tRNA-specific 2-thiouridylase genetic 1 1 1 Negative Genetic
YDL180W YDL180W Putative protein of unknown function genetic 1 1 1 Negative Genetic
SWF1 YDR126W Palmitoyltransferase that acts on transmembrane proteins genetic 1 1 1 Negative Genetic
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RPS4B YHR203C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
UBP7 YIL156W Ubiquitin-specific protease that cleaves ubiquitin-protein fusions genetic 1 1 1 Negative Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
PTK2 YJR059W Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 1 1 1 Negative Genetic
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Negative Genetic
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Negative Genetic
SNX4 YJL036W Sorting nexin genetic 1 1 1 Negative Genetic
VPS25 YJR102C Component of the ESCRT-II complex genetic 1 1 1 Negative Genetic
SEC72 YLR292C Non-essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
VRP1 YLR337C Verprolin, proline-rich actin-associated protein genetic 1 1 1 Negative Genetic
VPS36 YLR417W Component of the ESCRT-II complex genetic 1 1 1 Negative Genetic
TUS1 YLR425W Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity genetic 1 1 1 Negative Genetic
VAN1 YML115C Component of the mannan polymerase I genetic 1 1 1 Negative Genetic
PAI3 YMR174C Cytoplasmic proteinase A (Pep4p) inhibitor genetic 1 1 1 Negative Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Negative Genetic
WSC2 YNL283C Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway genetic 1 1 1 Negative Genetic
YNR021W YNR021W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YOL057W YOL057W Dipeptidyl-peptidase III genetic 1 1 1 Negative Genetic
YOR186W YOR186W Putative protein of unknown function genetic 1 1 1 Negative Genetic
VTS1 YOR359W Flap-structured DNA-binding and RNA-binding protein genetic 1 1 1 Negative Genetic
RQC2 YPL009C Component of the Ribosome Quality Control (RQC) complex genetic 1 1 1 Negative Genetic
RGL1 YPL066W Regulator of Rho1p signaling, cofactor of Tus1p genetic 1 1 1 Negative Genetic
TAF14 YPL129W Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes genetic 1 1 1 Negative Genetic
TPK2 YPL203W cAMP-dependent protein kinase catalytic subunit genetic 1 1 1 Negative Genetic
TEF1 YPR080W Translational elongation factor EF-1 alpha genetic 1 1 1 Negative Genetic
SNT309 YPR101W Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
PET127 YOR017W Protein with a role in 5'-end processing of mitochondrial RNAs genetic 1 1 1 Positive Genetic
SEC53 YFL045C Phosphomannomutase genetic 1 1 1 Negative Genetic
PRP8 YHR165C Component of U4/U6-U5 snRNP complex genetic 1 1 1 Negative Genetic
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 1 1 1 Negative Genetic
NEM1 YHR004C Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme genetic 1 1 1 Negative Genetic
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 1 1 1 Negative Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Rescue
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Positive Genetic
MSC1 YML128C Protein of unknown function genetic 1 1 1 Positive Genetic
CDC1 YDR182W Putative mannose-ethanolamine phosphate phosphodiesterase genetic 1 1 1 Negative Genetic
HST2 YPL015C Cytoplasmic NAD(+)-dependent protein deacetylase genetic 1 1 1 Negative Genetic
FSH2 YMR222C Putative serine hydrolase that localizes to the cytoplasm genetic 1 1 1 Negative Genetic
NAR1 YNL240C Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery genetic 1 1 1 Positive Genetic
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Positive Genetic
DBR1 YKL149C RNA lariat debranching enzyme genetic 1 1 1 Negative Genetic