Standard name Systematic name Name description Description
GUK1 YDR454C Guanylate kinase Guanylate kinase; converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins
Visualize the interactome of GUK1
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.991 0.991 1.0

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 20500

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
GUK1 2 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0330 (deoxyguanylate kinase (dGMP:ATP)), r_0529 (guanylate kinase (GMP:dATP)), r_0528 (guanylate kinase)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
HPT1 YDR399W Dimeric hypoxanthine-guanine phosphoribosyltransferase genetic 3 2 2 Dosage Rescue, Phenotypic Suppression, Phenotypic Suppression
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 2 2 2 Synthetic Rescue, Negative Genetic
GAA1 YLR088W Subunit of the GPI:protein transamidase complex genetic 2 2 2 Synthetic Rescue, Negative Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 2 1 2 Negative Genetic, Negative Genetic
ADO1 YJR105W Adenosine kinase genetic 2 1 2 Negative Genetic, Negative Genetic
ALG1 YBR110W Mannosyltransferase genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
CEG1 YGL130W Guanylyltransferase involved in mRNA 5' capping genetic 2 1 1 Negative Genetic, Negative Genetic
SEC4 YFL005W Rab family GTPase genetic 2 1 1 Negative Genetic, Negative Genetic
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis regulation 1 1 1 DNA to cDNA expression microarray evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci regulation 1 1 1 DNA to cDNA expression microarray evidence
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HSF1 YGL073W Trimeric heat shock transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
CST6 YIL036W Basic leucine zipper (bZIP) transcription factor from ATF/CREB family regulation 1 1 1 DNA to cDNA expression microarray evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Negative Genetic
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 1 1 1 Negative Genetic
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) genetic 1 1 1 Negative Genetic
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 1 1 1 Negative Genetic
ARP7 YPR034W Component of both the SWI/SNF and RSC chromatin remodeling complexes genetic 1 1 1 Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
BET2 YPR176C Beta subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CLP1 YOR250C Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Negative Genetic
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Negative Genetic
EMG1 YLR186W Methyltransferase for rRNA genetic 1 1 1 Negative Genetic
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control physical 1 1 1 Affinity Capture-MS
CMD1 YBR109C Calmodulin genetic 1 1 1 Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Phenotypic Suppression
ADE57 YGL234W Bifunctional enzyme of 'de novo' purine nucleotide pathway genetic 1 1 1 Negative Genetic
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 1 1 1 Negative Genetic
CCT8 YJL008C Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
FDH1 YOR388C NAD(+)-dependent formate dehydrogenase genetic 1 1 1 Negative Genetic
GSP1 YLR293C Ran GTPase genetic 1 1 1 Negative Genetic
GET1 YGL020C Subunit of the GET complex genetic 1 1 1 Negative Genetic
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Negative Genetic
ERG27 YLR100W 3-keto sterol reductase genetic 1 1 1 Negative Genetic
CCT3 YJL014W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
APE2 YKL157W Aminopeptidase yscII genetic 1 1 1 Negative Genetic
ARP1 YHR129C Actin-related protein of the dynactin complex genetic 1 1 1 Positive Genetic
BAS1 YKR099W Myb-related transcription factor genetic 1 1 1 Negative Genetic
AVO2 YMR068W Component of a complex containing the Tor2p kinase and other proteins genetic 1 1 1 Negative Genetic
AMD1 YML035C AMP deaminase genetic 1 1 1 Negative Genetic
CET1 YPL228W RNA 5'-triphosphatase involved in mRNA 5' capping genetic 1 1 1 Negative Genetic
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
BRN1 YBL097W Subunit of the condensin complex genetic 1 1 1 Negative Genetic
BUD4 YJR092W Anillin-like protein involved in bud-site selection genetic 1 1 1 Negative Genetic
CCZ1 YBR131W Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
GOS1 YHL031C v-SNARE protein involved in Golgi transport genetic 1 1 1 Negative Genetic
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system genetic 1 1 1 Negative Genetic
ESC1 YMR219W Protein involved in telomeric silencing genetic 1 1 1 Positive Genetic
GAB1 YLR459W Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Negative Genetic
DPM1 YPR183W Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane genetic 1 1 1 Negative Genetic
ADE1 YAR015W N-succinyl-5-aminoimidazole-4-carboxamide ribotide synthetase genetic 1 1 1 Negative Genetic
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
FCF2 YLR051C Nucleolar protein involved in the early steps of 35S rRNA processing genetic 1 1 1 Negative Genetic
YEL023C YEL023C Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
PSK1 YAL017W PAS domain-containing serine/threonine protein kinase physical 1 1 1 Biochemical Activity
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 1 1 1 Affinity Capture-MS
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
ULP1 YPL020C Protease that specifically cleaves Smt3p protein conjugates physical 1 1 1 PCA
ULP2 YIL031W Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins physical 1 1 1 PCA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 1 1 1 Affinity Capture-MS
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
RRP6 YOR001W Nuclear exosome exonuclease component physical 1 1 1 Affinity Capture-MS
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p physical 1 1 1 Affinity Capture-MS
MYG1 YER156C Protein involved in mitochondrial function physical 1 1 1 Proximity Label-MS
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
SOL2 YCR073W-A Protein with a possible role in tRNA export genetic 1 1 1 Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Negative Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Negative Genetic
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Negative Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Synthetic Growth Defect
MET22 YOL064C Bisphosphate-3'-nucleotidase genetic 1 1 1 Synthetic Growth Defect
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 1 1 1 Synthetic Lethality
RAD51 YER095W Strand exchange protein genetic 1 1 1 Synthetic Lethality
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer genetic 1 1 1 Positive Genetic
LSM8 YJR022W Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
SWC3 YAL011W Protein of unknown function genetic 1 1 1 Positive Genetic
SHG1 YBR258C Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Positive Genetic
MIG1 YGL035C Transcription factor involved in glucose repression genetic 1 1 1 Positive Genetic
MON1 YGL124C Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Positive Genetic
MUP3 YHL036W Low affinity methionine permease genetic 1 1 1 Positive Genetic
YIA6 YIL006W Mitochondrial NAD+ transporter genetic 1 1 1 Positive Genetic
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 1 1 1 Positive Genetic
MLP1 YKR095W Myosin-like protein associated with the nuclear envelope genetic 1 1 1 Positive Genetic
RAD10 YML095C Single-stranded DNA endonuclease (with Rad1p) genetic 1 1 1 Positive Genetic
MSH2 YOL090W Protein that binds to DNA mismatches genetic 1 1 1 Positive Genetic
PPQ1 YPL179W Protein phosphatase that regulates the mating response genetic 1 1 1 Positive Genetic
NFU1 YKL040C Protein involved in Fe-S cluster transfer to mitochondrial clients genetic 1 1 1 Positive Genetic
RER2 YBR002C Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1 genetic 1 1 1 Negative Genetic
RIB5 YBR256C Riboflavin synthase genetic 1 1 1 Negative Genetic
MPS1 YDL028C Dual-specificity kinase genetic 1 1 1 Negative Genetic
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 1 1 1 Negative Genetic
SUP35 YDR172W Translation termination factor eRF3 genetic 1 1 1 Negative Genetic
SKI6 YGR195W Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
MAS2 YHR024C Alpha subunit of the mitochondrial processing protease (MPP) genetic 1 1 1 Negative Genetic
NUP192 YJL039C Essential subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
PAM18 YLR008C Subunit of the import motor (PAM complex) genetic 1 1 1 Negative Genetic
RNT1 YMR239C Nuclear dsRNA-specific ribonuclease (RNase III) genetic 1 1 1 Negative Genetic
RPC34 YNR003C RNA polymerase III subunit C34 genetic 1 1 1 Negative Genetic
RPA190 YOR341W RNA polymerase I largest subunit A190 genetic 1 1 1 Negative Genetic
MOT1 YPL082C Essential protein involved in regulation of transcription genetic 1 1 1 Negative Genetic
HRR25 YPL204W Conserved casein kinase, monopolin subunit genetic 1 1 1 Negative Genetic
SUA7 YPR086W Transcription factor TFIIB genetic 1 1 1 Negative Genetic
SRP54 YPR088C Signal recognition particle (SRP) subunit (homolog of mammalian SRP54) genetic 1 1 1 Negative Genetic
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Negative Genetic
TSC11 YER093C Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
SEC11 YIR022W 18kDa catalytic subunit of the Signal Peptidase Complex (SPC) genetic 1 1 1 Negative Genetic
TFA1 YKL028W TFIIE large subunit genetic 1 1 1 Negative Genetic
SRP102 YKL154W Signal recognition particle (SRP) receptor beta subunit genetic 1 1 1 Negative Genetic
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Negative Genetic
TPS1 YBR126C Synthase subunit of trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Negative Genetic
SSH1 YBR283C Subunit of the Ssh1 translocon complex genetic 1 1 1 Negative Genetic
OCA4 YCR095C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Negative Genetic
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p genetic 1 1 1 Negative Genetic
PHO2 YDL106C Homeobox transcription factor genetic 1 1 1 Negative Genetic
OST4 YDL232W Subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Negative Genetic
OCA6 YDR067C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Negative Genetic
IPT1 YDR072C Inositolphosphotransferase genetic 1 1 1 Negative Genetic
RIM15 YFL033C Protein kinase involved in cell proliferation in response to nutrients genetic 1 1 1 Negative Genetic
SAP155 YFR040W Protein required for function of the Sit4p protein phosphatase genetic 1 1 1 Negative Genetic
PIB2 YGL023C Phosphatidylinositol 3-phosphate binding protein genetic 1 1 1 Negative Genetic
RIM8 YGL045W Protein involved in proteolytic activation of Rim101p genetic 1 1 1 Negative Genetic
HNM1 YGL077C Plasma membrane transporter for choline, ethanolamine, and carnitine genetic 1 1 1 Negative Genetic
PAN2 YGL094C Catalytic subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex genetic 1 1 1 Negative Genetic
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SNG1 YGR197C Protein involved in resistance to nitrosoguanidine and 6-azauracil genetic 1 1 1 Negative Genetic
NPR3 YHL023C Subunit of the Iml1p/SEACIT complex genetic 1 1 1 Negative Genetic
KSP1 YHR082C Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
YJL206C YJL206C Putative protein of unknown function genetic 1 1 1 Negative Genetic
IMA5 YJL216C Alpha-glucosidase genetic 1 1 1 Negative Genetic
TMA19 YKL056C Protein that associates with ribosomes genetic 1 1 1 Negative Genetic
LST4 YKL176C Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p genetic 1 1 1 Negative Genetic
PUF3 YLL013C Protein of the mitochondrial outer surface genetic 1 1 1 Negative Genetic
UBR2 YLR024C Cytoplasmic ubiquitin-protein ligase (E3) genetic 1 1 1 Negative Genetic
SHM2 YLR058C Cytosolic serine hydroxymethyltransferase genetic 1 1 1 Negative Genetic
UPS1 YLR193C Phosphatidic acid transfer protein genetic 1 1 1 Negative Genetic
SYM1 YLR251W Protein required for ethanol metabolism genetic 1 1 1 Negative Genetic
RPL31B YLR406C Ribosomal 60S subunit protein L31B genetic 1 1 1 Negative Genetic
PFK2 YMR205C Beta subunit of heterooctameric phosphofructokinase genetic 1 1 1 Negative Genetic
SIW14 YNL032W Inositol phosphatase involved in inositol pyrophosphate metabolism genetic 1 1 1 Negative Genetic
YNL046W YNL046W Putative protein of unknown function genetic 1 1 1 Negative Genetic
MKS1 YNL076W Pleiotropic negative transcriptional regulator genetic 1 1 1 Negative Genetic
SWS2 YNL081C Putative mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
OCA1 YNL099C Putative protein tyrosine phosphatase genetic 1 1 1 Negative Genetic
TOP1 YOL006C Topoisomerase I genetic 1 1 1 Negative Genetic
SDH5 YOL071W Protein required for flavinylation of Sdh1p genetic 1 1 1 Negative Genetic
MSN1 YOL116W Transcriptional activator genetic 1 1 1 Negative Genetic
RTC1 YOL138C Subunit of SEACAT, a subcomplex of the SEA complex genetic 1 1 1 Negative Genetic
VPS17 YOR132W Subunit of the membrane-associated retromer complex genetic 1 1 1 Negative Genetic
RIM20 YOR275C Protein involved in proteolytic activation of Rim101p genetic 1 1 1 Negative Genetic
PDE2 YOR360C High-affinity cyclic AMP phosphodiesterase genetic 1 1 1 Negative Genetic
OAZ1 YPL052W Regulator of ornithine decarboxylase Spe1p genetic 1 1 1 Negative Genetic
PCL8 YPL219W Cyclin genetic 1 1 1 Negative Genetic
THP3 YPR045C Protein that may have a role in transcription elongation genetic 1 1 1 Negative Genetic
UBA3 YPR066W Protein that activates Rub1p (NEDD8) before neddylation genetic 1 1 1 Negative Genetic
SUE1 YPR151C Protein required for degradation of unstable forms of cytochrome c genetic 1 1 1 Negative Genetic
SKI3 YPR189W Ski complex component and TPR protein genetic 1 1 1 Negative Genetic
LAA2 YBL010C Clathrin adaptor (adaptin) accessory protein genetic 1 1 1 Negative Genetic
REG2 YBR050C Regulatory subunit of the Glc7p type-1 protein phosphatase genetic 1 1 1 Negative Genetic
STP22 YCL008C Component of the ESCRT-I complex genetic 1 1 1 Negative Genetic
MATALPHA2 YCR039C Homeobox-domain protein genetic 1 1 1 Negative Genetic
MSS2 YDL107W Peripherally bound inner membrane protein of the mitochondrial matrix genetic 1 1 1 Negative Genetic
ICL1 YER065C Isocitrate lyase genetic 1 1 1 Negative Genetic
TIF4632 YGL049C Translation initiation factor eIF4G and scaffold protein genetic 1 1 1 Negative Genetic
NCS6 YGL211W Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs genetic 1 1 1 Negative Genetic
OCA5 YHL029C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Negative Genetic
YHR213W-B YHR213W-B Pseudogenic fragment with similarity to flocculins genetic 1 1 1 Negative Genetic
IRC8 YJL051W Bud tip localized protein of unknown function genetic 1 1 1 Negative Genetic
SDH2 YLL041C Iron-sulfur protein subunit of succinate dehydrogenase genetic 1 1 1 Negative Genetic
MTG1 YMR097C Putative GTPase peripheral to the mitochondrial inner membrane genetic 1 1 1 Negative Genetic
VAC7 YNL054W Integral vacuolar membrane protein genetic 1 1 1 Negative Genetic
SIP3 YNL257C Putative sterol transfer protein genetic 1 1 1 Negative Genetic
SER1 YOR184W 3-phosphoserine aminotransferase genetic 1 1 1 Negative Genetic
MGR2 YPL098C Subunit of the TIM23 translocase complex genetic 1 1 1 Negative Genetic
INA17 YPL099C F1F0 ATPase synthase peripheral stalk assembly factor genetic 1 1 1 Negative Genetic
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Positive Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
CYB5 YNL111C Cytochrome b5 genetic 1 1 1 Negative Genetic
COA4 YLR218C Twin Cx(9)C protein involved in cytochrome c oxidase organization genetic 1 1 1 Negative Genetic
GCV3 YAL044C H subunit of the mitochondrial glycine decarboxylase complex genetic 1 1 1 Negative Genetic
GEM1 YAL048C Outer mitochondrial membrane GTPase, subunit of the ERMES complex genetic 1 1 1 Negative Genetic
ARO2 YGL148W Bifunctional chorismate synthase and flavin reductase genetic 1 1 1 Negative Genetic
GPI12 YMR281W ER membrane protein involved in the second step of GPI anchor assembly genetic 1 1 1 Negative Genetic
EOS1 YNL080C Protein involved in N-glycosylation genetic 1 1 1 Synthetic Rescue
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) genetic 1 1 1 Synthetic Rescue
ATG41 YPL250C Protein of unknown function genetic 1 1 1 Negative Genetic
CDC1 YDR182W Putative mannose-ethanolamine phosphate phosphodiesterase genetic 1 1 1 Negative Genetic
COX16 YJL003W Mitochondrial inner membrane protein genetic 1 1 1 Negative Genetic
CHM7 YJL049W Yeast homolog of human CHMP7, localizes to the endoplasmic reticulum genetic 1 1 1 Negative Genetic
BER1 YLR412W Protein involved in microtubule-related processes genetic 1 1 1 Negative Genetic
CTM1 YHR109W Cytochrome c lysine methyltransferase genetic 1 1 1 Positive Genetic
ECM8 YBR076W Non-essential protein of unknown function genetic 1 1 1 Negative Genetic