| BNR1 |
YIL159W |
Formin |
genetic |
21 |
5 |
19 |
Synthetic Lethality, Phenotypic Enhancement, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Lethality, Phenotypic Enhancement, Synthetic Rescue, Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
| BUD6 |
YLR319C |
Actin- and formin-interacting protein |
genetic |
11 |
4 |
9 |
Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic |
| NIP100 |
YPL174C |
Large subunit of the dynactin complex |
genetic |
10 |
4 |
7 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic |
| DYN1 |
YKR054C |
Cytoplasmic heavy chain dynein |
genetic |
9 |
3 |
7 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
| SLT2 |
YHR030C |
Serine/threonine MAP kinase |
genetic |
9 |
3 |
7 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| ARP1 |
YHR129C |
Actin-related protein of the dynactin complex |
genetic |
9 |
3 |
7 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
| CYK3 |
YDL117W |
SH3-domain protein located in the bud neck and cytokinetic actin ring |
genetic |
8 |
4 |
6 |
Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic |
| CHS7 |
YHR142W |
Protein of unknown function |
genetic |
8 |
3 |
5 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic |
| BCK1 |
YJL095W |
MAPKKK acting in the protein kinase C signaling pathway |
genetic |
7 |
2 |
7 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| NUM1 |
YDR150W |
Protein required for nuclear migration |
genetic |
7 |
3 |
5 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Negative Genetic |
| JNM1 |
YMR294W |
Component of the yeast dynactin complex |
genetic |
7 |
3 |
5 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| NBP2 |
YDR162C |
Protein involved in the HOG (high osmolarity glycerol) pathway |
genetic |
7 |
3 |
5 |
Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
| PAC1 |
YOR269W |
Regulator of dynein, involved in intracellular transport |
genetic |
7 |
2 |
5 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic |
| ASE1 |
YOR058C |
Mitotic spindle midzone-localized microtubule bundling protein |
genetic |
7 |
3 |
4 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect |
| CLA4 |
YNL298W |
Cdc42p-activated signal transducing kinase |
genetic |
7 |
2 |
4 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Synthetic Lethality |
| BNI4 |
YNL233W |
Targeting subunit for Glc7p protein phosphatase |
genetic |
7 |
2 |
4 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect |
| BUD6 |
YLR319C |
Actin- and formin-interacting protein |
physical |
6 |
3 |
6 |
Two-hybrid, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, PCA |
| BNI1 |
YNL271C |
Formin |
physical |
6 |
3 |
5 |
Reconstituted Complex, Co-crystal Structure, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex |
| CHS3 |
YBR023C |
Chitin synthase III |
genetic |
6 |
3 |
4 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
| SKT5 |
YBL061C |
Activator of Chs3p (chitin synthase III) during vegetative growth |
genetic |
6 |
3 |
4 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
| DYN3 |
YMR299C |
Dynein light intermediate chain (LIC) |
genetic |
6 |
3 |
4 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
| BBC1 |
YJL020C |
Protein possibly involved in assembly of actin patches |
genetic |
6 |
3 |
4 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
| PAC11 |
YDR488C |
Dynein intermediate chain, microtubule motor protein |
genetic |
6 |
2 |
4 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic |
| SMI1 |
YGR229C |
Protein involved in the regulation of cell wall synthesis |
genetic |
6 |
2 |
4 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality |
| SHS1 |
YDL225W |
Component of the septin ring that is required for cytokinesis |
genetic |
6 |
3 |
3 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement |
| DYN2 |
YDR424C |
Cytoplasmic light chain dynein, microtubule motor protein |
genetic |
6 |
3 |
3 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect |
| ELP3 |
YPL086C |
Subunit of Elongator complex |
genetic |
5 |
3 |
5 |
Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
| CDC42 |
YLR229C |
Small rho-like GTPase |
physical |
5 |
1 |
5 |
Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid |
| MMR1 |
YLR190W |
Phosphorylated protein of the mitochondrial outer membrane |
genetic |
5 |
3 |
4 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic |
| SWI4 |
YER111C |
DNA binding component of the SBF complex (Swi4p-Swi6p) |
genetic |
5 |
3 |
4 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| PFY1 |
YOR122C |
Profilin |
genetic |
4 |
4 |
4 |
Dosage Lethality, Phenotypic Enhancement, Synthetic Lethality, Negative Genetic |
| PCL1 |
YNL289W |
Cyclin, interacts with cyclin-dependent kinase Pho85p |
genetic |
4 |
4 |
4 |
Synthetic Lethality, Phenotypic Enhancement, Dosage Lethality, Synthetic Growth Defect |
| ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
physical |
4 |
3 |
4 |
Two-hybrid, Reconstituted Complex, Biochemical Activity, Reconstituted Complex |
| NAP1 |
YKR048C |
Histone chaperone and assembly chaperone for Rps6a/b |
genetic |
4 |
3 |
4 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
| SWE1 |
YJL187C |
Protein kinase that regulates the G2/M transition |
genetic |
4 |
3 |
4 |
Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic |
| PHO85 |
YPL031C |
Cyclin-dependent kinase |
genetic |
4 |
3 |
4 |
Synthetic Lethality, Synthetic Growth Defect, Dosage Lethality, Synthetic Lethality |
| CHS5 |
YLR330W |
Component of the exomer complex |
genetic |
4 |
3 |
4 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
| UBA4 |
YHR111W |
E1-like protein that activates Urm1p before urmylation |
genetic |
4 |
3 |
4 |
Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| ELP4 |
YPL101W |
Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex |
genetic |
4 |
3 |
4 |
Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| LDB18 |
YLL049W |
Component of the dynactin complex |
genetic |
4 |
3 |
4 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
| IKI3 |
YLR384C |
Subunit of Elongator complex |
genetic |
4 |
3 |
4 |
Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Negative Genetic |
| BEM3 |
YPL115C |
Rho GTPase activating protein (RhoGAP) |
genetic |
4 |
3 |
4 |
Phenotypic Enhancement, Dosage Rescue, Negative Genetic, Negative Genetic |
| BEM4 |
YPL161C |
Protein involved in establishment of cell polarity and bud emergence |
genetic |
4 |
3 |
4 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
| BEM2 |
YER155C |
Rho GTPase activating protein (RhoGAP) |
genetic |
4 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic |
| PFY1 |
YOR122C |
Profilin |
physical |
4 |
2 |
4 |
Two-hybrid, Two-hybrid, Two-hybrid, Biochemical Activity |
| SNC2 |
YOR327C |
Vesicle membrane receptor protein (v-SNARE) |
genetic |
4 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic |
| ELP2 |
YGR200C |
Subunit of Elongator complex |
genetic |
4 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic |
| ATS1 |
YAL020C |
Protein required for modification of wobble nucleosides in tRNA |
genetic |
4 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic |
| ELM1 |
YKL048C |
Serine/threonine protein kinase |
genetic |
4 |
3 |
3 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement |
| GIN4 |
YDR507C |
Protein kinase involved in bud growth and assembly of the septin ring |
genetic |
4 |
3 |
3 |
Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement |
| NCS2 |
YNL119W |
Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs |
genetic |
4 |
3 |
3 |
Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect |
| BIL1 |
YOR304C-A |
Protein that binds Bud6p and has a role in actin cable assembly |
genetic |
4 |
3 |
3 |
Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic |
| IPK1 |
YDR315C |
Inositol 1,3,4,5,6-pentakisphosphate 2-kinase |
genetic |
4 |
2 |
3 |
Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic |
| ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
4 |
4 |
2 |
Phenotypic Suppression, Synthetic Growth Defect, Dosage Rescue, Negative Genetic |
| PKC1 |
YBL105C |
Protein serine/threonine kinase |
genetic |
3 |
3 |
3 |
Dosage Rescue, Synthetic Lethality, Negative Genetic |
| BUD14 |
YAR014C |
Protein involved in bud-site selection |
genetic |
3 |
3 |
3 |
Synthetic Rescue, Synthetic Lethality, Phenotypic Enhancement |
| RHO1 |
YPR165W |
GTP-binding protein of the rho subfamily of Ras-like proteins |
physical |
3 |
2 |
3 |
Two-hybrid, Two-hybrid, Affinity Capture-Western |
| TPM1 |
YNL079C |
Major isoform of tropomyosin |
genetic |
3 |
2 |
3 |
Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue |
| FAB1 |
YFR019W |
1-phosphatidylinositol-3-phosphate 5-kinase |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic |
| DRS2 |
YAL026C |
Trans-golgi network aminophospholipid translocase (flippase) |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic |
| YPT6 |
YLR262C |
Rab family GTPase |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect |
| TUS1 |
YLR425W |
Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality |
| ELP6 |
YMR312W |
Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
| VAC14 |
YLR386W |
Enzyme regulator |
genetic |
3 |
2 |
3 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| INO2 |
YDR123C |
Transcription factor |
genetic |
3 |
2 |
3 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic |
| CHS6 |
YJL099W |
Member of the ChAPs (Chs5p-Arf1p-binding proteins) family |
genetic |
3 |
2 |
3 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic |
| BEM1 |
YBR200W |
Protein containing SH3-domains |
genetic |
3 |
1 |
3 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality |
| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
physical |
3 |
1 |
3 |
Biochemical Activity, Biochemical Activity, Biochemical Activity |
| DNM1 |
YLL001W |
Dynamin-related GTPase involved in mitochondrial organization |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| DMA1 |
YHR115C |
Ubiquitin-protein ligase (E3) |
genetic |
3 |
3 |
2 |
Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement |
| DMA2 |
YNL116W |
Ubiquitin-protein ligase (E3) |
genetic |
3 |
3 |
2 |
Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement |
| SLA2 |
YNL243W |
Adaptor protein that links actin to clathrin and endocytosis |
genetic |
3 |
3 |
2 |
Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement |
| PTC1 |
YDL006W |
Type 2C protein phosphatase (PP2C) |
genetic |
3 |
3 |
2 |
Negative Genetic, Phenotypic Suppression, Synthetic Growth Defect |
| SHE1 |
YBL031W |
Mitotic spindle protein |
genetic |
3 |
2 |
2 |
Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement |
| EMI1 |
YDR512C |
Non-essential protein of unknown function |
genetic |
3 |
2 |
2 |
Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement |
| EOS1 |
YNL080C |
Protein involved in N-glycosylation |
genetic |
3 |
2 |
2 |
Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement |
| KAR9 |
YPL269W |
Spindle positioning factor |
genetic |
3 |
1 |
2 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement |
| SMY1 |
YKL079W |
Kinesin-like myosin passenger-protein |
genetic |
3 |
3 |
1 |
Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality |
| ARP2 |
YDL029W |
Essential component of the Arp2/3 complex |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Reconstituted Complex |
| SPA2 |
YLL021W |
Component of the polarisome |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
| MSB3 |
YNL293W |
Rab GTPase-activating protein |
physical |
2 |
2 |
2 |
Two-hybrid, Reconstituted Complex |
| GIC2 |
YDR309C |
Rho-family GTPase interacting protein and Cdc42p effector |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Dosage Rescue |
| EDE1 |
YBL047C |
Scaffold protein involved in the formation of early endocytic sites |
physical |
2 |
2 |
2 |
Reconstituted Complex, PCA |
| SAC6 |
YDR129C |
Fimbrin, actin-bundling protein |
physical |
2 |
2 |
2 |
Reconstituted Complex, PCA |
| SLA1 |
YBL007C |
Cytoskeletal protein binding protein |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
| CDC10 |
YCR002C |
Component of the septin ring, required for cytokinesis |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Negative Genetic |
| CAP1 |
YKL007W |
Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p) |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| SSA1 |
YAL005C |
ATPase involved in protein folding and NLS-directed nuclear transport |
physical |
2 |
2 |
2 |
Reconstituted Complex, Affinity Capture-MS |
| YKE2 |
YLR200W |
Subunit of the heterohexameric Gim/prefoldin protein complex |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
| PCL2 |
YDL127W |
Cyclin, interacts with cyclin-dependent kinase Pho85p |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Dosage Lethality |
| CDC15 |
YAR019C |
Hippo-like kinase of the Mitotic Exit Network |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Negative Genetic |
| HYP2 |
YEL034W |
Translation elongation factor eIF-5A |
genetic |
2 |
2 |
2 |
Dosage Rescue, Phenotypic Suppression |
| TLG2 |
YOL018C |
Syntaxin-like t-SNARE |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Phenotypic Enhancement |
| HDA1 |
YNL021W |
Catalytic subunit of class II HDA1 histone deacetylase complex |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
| MYO1 |
YHR023W |
Type II myosin heavy chain |
genetic |
2 |
2 |
2 |
Dosage Rescue, Synthetic Lethality |
| FKS1 |
YLR342W |
Catalytic subunit of 1,3-beta-D-glucan synthase |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Synthetic Lethality |
| LCB2 |
YDR062W |
Component of serine palmitoyltransferase |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| SEC3 |
YER008C |
Subunit of the exocyst complex |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Synthetic Lethality |
| AXL2 |
YIL140W |
Integral plasma membrane protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| AIM21 |
YIR003W |
Subunit of a complex that associates with actin filaments |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| CDC48 |
YDL126C |
AAA ATPase with protein-unfoldase activity |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| CDC42 |
YLR229C |
Small rho-like GTPase |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
| FUS1 |
YCL027W |
Membrane protein localized to the shmoo tip |
physical |
2 |
1 |
2 |
Two-hybrid, Two-hybrid |
| DYN1 |
YKR054C |
Cytoplasmic heavy chain dynein |
physical |
2 |
1 |
2 |
Two-hybrid, Two-hybrid |
| PIN4 |
YBL051C |
Protein involved in G2/M phase progression and response to DNA damage |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
| RGD1 |
YBR260C |
GTPase-activating protein (RhoGAP) for Rho3p and Rho4p |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| VPS28 |
YPL065W |
Component of the ESCRT-I complex |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
| STE11 |
YLR362W |
Signal transducing MEK kinase |
genetic |
2 |
1 |
2 |
Phenotypic Suppression, Phenotypic Suppression |
| SCS2 |
YER120W |
Integral ER membrane protein, regulates phospholipid metabolism |
genetic |
2 |
1 |
2 |
Phenotypic Enhancement, Phenotypic Enhancement |
| SWF1 |
YDR126W |
Palmitoyltransferase that acts on transmembrane proteins |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SWI5 |
YDR146C |
Transcription factor that recruits Mediator and Swi/Snf complexes |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SHE9 |
YDR393W |
Protein required for normal mitochondrial morphology |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| NCS6 |
YGL211W |
Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SWI6 |
YLR182W |
Transcription cofactor |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| VRP1 |
YLR337C |
Verprolin, proline-rich actin-associated protein |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
| VIP1 |
YLR410W |
Bifunctional inositol pyrophosphate kinase and phosphatase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| NBA1 |
YOL070C |
Protein involved in axial bud site selection |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| CSI2 |
YOL007C |
Protein of unknown function |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| RGL1 |
YPL066W |
Regulator of Rho1p signaling, cofactor of Tus1p |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| XRN1 |
YGL173C |
Evolutionarily-conserved 5'-3' exonuclease |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| AIP5 |
YFR016C |
Protein that positively regulates actin assembly |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| AIM44 |
YPL158C |
Regulator of Cdc42p and Rho1p |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SPA2 |
YLL021W |
Component of the polarisome |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| MYO3 |
YKL129C |
One of two type I myosins |
physical |
2 |
2 |
1 |
Affinity Capture-Western, Two-hybrid |
| CDC14 |
YFR028C |
Protein phosphatase required for mitotic exit |
physical |
2 |
2 |
1 |
Affinity Capture-MS, Reconstituted Complex |
| RSP5 |
YER125W |
NEDD4 family E3 ubiquitin ligase |
physical |
2 |
2 |
1 |
Biochemical Activity, Affinity Capture-Western |
| BOI1 |
YBL085W |
Protein involved in polar growth, functionally redundant with Boi2p |
physical |
2 |
2 |
1 |
PCA, Reconstituted Complex |
| ERG2 |
YMR202W |
C-8 sterol isomerase |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Synthetic Lethality |
| ERG3 |
YLR056W |
C-5 sterol desaturase |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Synthetic Lethality |
| BIM1 |
YER016W |
Microtubule plus end-tracking protein |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Synthetic Lethality |
| CTF19 |
YPL018W |
Outer kinetochore protein, needed for accurate chromosome segregation |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| SAC6 |
YDR129C |
Fimbrin, actin-bundling protein |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| KIP3 |
YGL216W |
Kinesin-related antiparallel sliding motor protein |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| BUD4 |
YJR092W |
Anillin-like protein involved in bud-site selection |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| PES4 |
YFR023W |
Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| EMI2 |
YDR516C |
Hexokinase expressed during growth with low glucose levels |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| CTF3 |
YLR381W |
Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| IML3 |
YBR107C |
Outer kinetochore protein and component of the Ctf19 complex |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| SLI15 |
YBR156C |
Subunit of the conserved chromosomal passenger complex (CPC) |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| HLR1 |
YDR528W |
Protein involved in regulation of cell wall composition and integrity |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| RPP1B |
YDL130W |
Ribosomal protein P1 beta |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| YAR028W |
YAR028W |
Putative integral membrane protein |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| YNR021W |
YNR021W |
Putative protein of unknown function |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| GIM3 |
YNL153C |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| PAC10 |
YGR078C |
Part of the heteromeric co-chaperone GimC/prefoldin complex |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| UTR2 |
YEL040W |
Chitin transglycosylase |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| RAX2 |
YLR084C |
Protein required for the maintenance of bud site selection |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| CTF4 |
YPR135W |
Chromatin-associated protein |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| RAD61 |
YDR014W |
Subunit of a complex that inhibits sister chromatid cohesion |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| YRF1-6 |
YNL339C |
Helicase encoded by the Y' element of subtelomeric regions |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| DIN7 |
YDR263C |
Mitochondrial nuclease functioning in DNA repair and replication |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| UBP14 |
YBR058C |
Ubiquitin-specific protease |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| SKO1 |
YNL167C |
Basic leucine zipper transcription factor of the ATF/CREB family |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| SEG1 |
YMR086W |
Component of eisosome required for proper eisosome assembly |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| THP3 |
YPR045C |
Protein that may have a role in transcription elongation |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| KAR3 |
YPR141C |
Minus-end-directed microtubule motor |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| PAC2 |
YER007W |
Microtubule effector required for tubulin heterodimer formation |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| CIN2 |
YPL241C |
GTPase-activating protein (GAP) for Cin4p |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| SHE4 |
YOR035C |
Protein containing a UCS (UNC-45/CRO1/SHE4) domain |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| SCP1 |
YOR367W |
Component of yeast cortical actin cytoskeleton |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| SCW4 |
YGR279C |
Cell wall protein with similarity to glucanases |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| RAD55 |
YDR076W |
Protein that stimulates strand exchange |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| RTT109 |
YLL002W |
Histone acetyltransferase |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| LAS21 |
YJL062W |
Mannose-ethanolamine phosphotransferase |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| MXR2 |
YCL033C |
Methionine-R-sulfoxide reductase |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| YBR238C |
YBR238C |
Mitochondrial membrane protein |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| YAP1801 |
YHR161C |
Protein of the AP180 family, involved in clathrin cage assembly |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| STI1 |
YOR027W |
Evolutionarily-conserved Hsp90 cochaperone |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| BTT1 |
YDR252W |
Heterotrimeric nascent polypeptide-associated complex beta3 subunit |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| TOR1 |
YJR066W |
PIK-related protein kinase and rapamycin target |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| PER33 |
YLR064W |
Protein that localizes to the endoplasmic reticulum |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| VHC1 |
YBR235W |
Vacuolar membrane cation-chloride cotransporter (CCC) |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| YPL191C |
YPL191C |
K48-specific deubiquitinating (DUB) enzyme |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| YML096W |
YML096W |
Putative protein with similarity to asparagine synthetases |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| YHR022C |
YHR022C |
Putative protein of unknown function |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| BUD7 |
YOR299W |
Member of the ChAPs family (Chs5p-Arf1p-binding proteins) |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| GRX2 |
YDR513W |
Cytoplasmic glutaredoxin |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| CHL4 |
YDR254W |
Outer kinetochore protein required for chromosome stability |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| SIF2 |
YBR103W |
WD40 repeat-containing subunit of Set3C histone deacetylase complex |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| DIP5 |
YPL265W |
Dicarboxylic amino acid permease |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| GAL83 |
YER027C |
One of three alternate beta-subunits of the Snf1 kinase complex |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| UBP16 |
YPL072W |
Deubiquitinating enzyme anchored to the outer mitochondrial membrane |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| PFA5 |
YDR459C |
Palmitoyltransferase with autoacylation activity |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| ECM8 |
YBR076W |
Non-essential protein of unknown function |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| ERV2 |
YPR037C |
Flavin-linked sulfhydryl oxidase localized to the ER lumen |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| YAF9 |
YNL107W |
Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| HCM1 |
YCR065W |
Forkhead transcription factor |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| MIS1 |
YBR084W |
Mitochondrial C1-tetrahydrofolate synthase |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| YTP1 |
YNL237W |
Probable type-III integral membrane protein of unknown function |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| YLR012C |
YLR012C |
Putative protein of unknown function |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| TDA5 |
YLR426W |
Putative protein of unknown function |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| BIK1 |
YCL029C |
Microtubule-associated protein |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| YAP6 |
YDR259C |
Basic leucine zipper (bZIP) transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| REB1 |
YBR049C |
RNA polymerase I enhancer binding protein |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| UME6 |
YDR207C |
Rpd3L histone deacetylase complex subunit |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| ARP4 |
YJL081C |
Nuclear actin-related protein involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ARL1 |
YBR164C |
Soluble GTPase with a role in regulation of membrane traffic |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ARC15 |
YIL062C |
Subunit of the ARP2/3 complex |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| ARC18 |
YLR370C |
Subunit of the ARP2/3 complex |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| ARC18 |
YLR370C |
Subunit of the ARP2/3 complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ARC19 |
YKL013C |
Subunit of the ARP2/3 complex |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| ARC40 |
YBR234C |
Subunit of the ARP2/3 complex |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| ARP2 |
YDL029W |
Essential component of the Arp2/3 complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ARP3 |
YJR065C |
Essential component of the Arp2/3 complex |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| FAL1 |
YDR021W |
Nucleolar protein required for maturation of 18S rRNA |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SPT15 |
YER148W |
TATA-binding protein (TBP) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| TEF1 |
YPR080W |
Translational elongation factor EF-1 alpha |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| NUM1 |
YDR150W |
Protein required for nuclear migration |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| HOF1 |
YMR032W |
F-BAR protein that regulates actin cytoskeleton organization |
physical |
1 |
1 |
1 |
Two-hybrid |
| HOF1 |
YMR032W |
F-BAR protein that regulates actin cytoskeleton organization |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RHO3 |
YIL118W |
Non-essential small GTPase of the Rho/Rac family of Ras-like proteins |
physical |
1 |
1 |
1 |
Two-hybrid |
| RHO3 |
YIL118W |
Non-essential small GTPase of the Rho/Rac family of Ras-like proteins |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| ZDS2 |
YML109W |
Protein with a role in regulating Swe1p-dependent polarized growth |
physical |
1 |
1 |
1 |
Two-hybrid |
| MYO3 |
YKL129C |
One of two type I myosins |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| PRP45 |
YAL032C |
Protein required for pre-mRNA splicing |
physical |
1 |
1 |
1 |
Two-hybrid |
| MYO5 |
YMR109W |
One of two type I myosin motors |
physical |
1 |
1 |
1 |
Two-hybrid |
| MYO5 |
YMR109W |
One of two type I myosin motors |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| MSB1 |
YOR188W |
Protein of unknown function |
physical |
1 |
1 |
1 |
Two-hybrid |
| TEF2 |
YBR118W |
Translational elongation factor EF-1 alpha |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| MSB4 |
YOL112W |
GTPase-activating protein of the Ras superfamily |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| FUS3 |
YBL016W |
Mitogen-activated serine/threonine protein kinase involved in mating |
physical |
1 |
1 |
1 |
Biochemical Activity |
| FUS3 |
YBL016W |
Mitogen-activated serine/threonine protein kinase involved in mating |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| TCB3 |
YML072C |
Cortical ER protein involved in ER-plasma membrane tethering |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| PSA1 |
YDL055C |
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| MRPS35 |
YGR165W |
Mitochondrial ribosomal protein of the small subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SGM1 |
YJR134C |
Protein of unknown function |
physical |
1 |
1 |
1 |
Two-hybrid |
| NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| HSP104 |
YLL026W |
Disaggregase |
physical |
1 |
1 |
1 |
Co-localization |
| BNR1 |
YIL159W |
Formin |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| URN1 |
YPR152C |
Protein of unknown function containing WW and FF domains |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| HHT1 |
YBR010W |
Histone H3 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| HHT2 |
YNL031C |
Histone H3 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| CMR1 |
YDL156W |
Nuclear protein with role in transcription, protein quality control |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| HDA2 |
YDR295C |
Subunit of HDA1 histone deacetylase complex |
physical |
1 |
1 |
1 |
Two-hybrid |
| TSC11 |
YER093C |
Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) |
physical |
1 |
1 |
1 |
Two-hybrid |
| TSC11 |
YER093C |
Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPC105 |
YGL093W |
Subunit of a kinetochore-microtubule binding complex |
physical |
1 |
1 |
1 |
Two-hybrid |
| YGR130C |
YGR130C |
Component of the eisosome with unknown function |
physical |
1 |
1 |
1 |
Two-hybrid |
| RPT5 |
YOR117W |
ATPase of the 19S regulatory particle of the 26S proteasome |
physical |
1 |
1 |
1 |
Two-hybrid |
| CTF19 |
YPL018W |
Outer kinetochore protein, needed for accurate chromosome segregation |
physical |
1 |
1 |
1 |
Two-hybrid |
| BRO1 |
YPL084W |
Cytoplasmic class E vacuolar protein sorting (VPS) factor |
physical |
1 |
1 |
1 |
Two-hybrid |
| GIC2 |
YDR309C |
Rho-family GTPase interacting protein and Cdc42p effector |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| HMT1 |
YBR034C |
Nuclear SAM-dependent mono- and asymmetric methyltransferase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| HMT1 |
YBR034C |
Nuclear SAM-dependent mono- and asymmetric methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SBP1 |
YHL034C |
Protein that binds eIF4G and has a role in repression of translation |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| STE20 |
YHL007C |
Cdc42p-activated signal transducing kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| MLP1 |
YKR095W |
Myosin-like protein associated with the nuclear envelope |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| PRK1 |
YIL095W |
Ser/Thr protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| PIN4 |
YBL051C |
Protein involved in G2/M phase progression and response to DNA damage |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| CMD1 |
YBR109C |
Calmodulin |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| CMD1 |
YBR109C |
Calmodulin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CAJ1 |
YER048C |
Nuclear type II J heat shock protein of the E. coli dnaJ family |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| MRP8 |
YKL142W |
Protein of unknown function |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| SEC9 |
YGR009C |
t-SNARE protein required for secretory vesicle-plasma membrane fusion |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| RTC3 |
YHR087W |
Protein of unknown function involved in RNA metabolism |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| RNR4 |
YGR180C |
Ribonucleotide-diphosphate reductase (RNR) small subunit |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| TPM1 |
YNL079C |
Major isoform of tropomyosin |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| KIN2 |
YLR096W |
S/T protein kinase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| SAR1 |
YPL218W |
ARF family GTPase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| SOD2 |
YHR008C |
Mitochondrial manganese superoxide dismutase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| RGD1 |
YBR260C |
GTPase-activating protein (RhoGAP) for Rho3p and Rho4p |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| SLA1 |
YBL007C |
Cytoskeletal protein binding protein |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| CUE5 |
YOR042W |
Ubiquitin-binding protein |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| CCP1 |
YKR066C |
Mitochondrial cytochrome-c peroxidase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| NTF2 |
YER009W |
Nuclear envelope protein |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| CCT2 |
YIL142W |
Subunit beta of the cytosolic chaperonin Cct ring complex |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| YMR196W |
YMR196W |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| NAP1 |
YKR048C |
Histone chaperone and assembly chaperone for Rps6a/b |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| HSC82 |
YMR186W |
Cytoplasmic chaperone of the Hsp90 family |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| CRN1 |
YLR429W |
Coronin |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| SNX41 |
YDR425W |
Sorting nexin |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| IDH1 |
YNL037C |
Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| YDR061W |
YDR061W |
Protein with similarity to ABC transporter family members |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| MCA1 |
YOR197W |
Ca2+-dependent cysteine protease |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| YDL124W |
YDL124W |
NADPH-dependent alpha-keto amide reductase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| SGT2 |
YOR007C |
Glutamine-rich cytoplasmic cochaperone |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| TUB3 |
YML124C |
Alpha-tubulin |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| SDS24 |
YBR214W |
Protein involved in cell separation during budding |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| SYP1 |
YCR030C |
Negative regulator of WASP-Arp23 complex |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| IVY1 |
YDR229W |
Phospholipid-binding protein that interacts with both Ypt7p and Vps33p |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| YNL208W |
YNL208W |
Protein of unknown function |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| PBI2 |
YNL015W |
Cytosolic inhibitor of vacuolar proteinase B (PRB1) |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| COX13 |
YGL191W |
Subunit VIa of cytochrome c oxidase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| HEM15 |
YOR176W |
Ferrochelatase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| CDC123 |
YLR215C |
Assembly factor for the eIF2 translation initiation factor complex |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| DCS2 |
YOR173W |
m(7)GpppX pyrophosphatase regulator |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| PST2 |
YDR032C |
FMN-dependent NAD(P)H:quinone oxidoreductase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| IPP1 |
YBR011C |
Cytoplasmic inorganic pyrophosphatase (PPase) |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| IPP1 |
YBR011C |
Cytoplasmic inorganic pyrophosphatase (PPase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KES1 |
YPL145C |
Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| DUG1 |
YFR044C |
Cys-Gly metallo-di-peptidase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| MEU1 |
YLR017W |
Methylthioadenosine phosphorylase (MTAP) |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| BZZ1 |
YHR114W |
SH3 domain protein implicated in regulating actin polymerization |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| UGP1 |
YKL035W |
UDP-glucose pyrophosphorylase (UGPase) |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| CDC10 |
YCR002C |
Component of the septin ring, required for cytokinesis |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| PRE5 |
YMR314W |
Alpha 6 subunit of the 20S proteasome |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| PRE5 |
YMR314W |
Alpha 6 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MAM33 |
YIL070C |
Acidic protein of the mitochondrial matrix |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| RNR3 |
YIL066C |
Minor isoform of large subunit of ribonucleotide-diphosphate reductase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| TWF1 |
YGR080W |
Twinfilin |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| LSB3 |
YFR024C-A |
Protein containing a C-terminal SH3 domain |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| TFS1 |
YLR178C |
Inhibitor of carboxypeptidase Y (Prc1p), and Ras GAP (Ira2p) |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| RNR2 |
YJL026W |
Ribonucleotide-diphosphate reductase (RNR), small subunit |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| PEX19 |
YDL065C |
Chaperone and import receptor for newly-synthesized class I PMPs |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| IDH2 |
YOR136W |
Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| YKT6 |
YKL196C |
Vesicle membrane protein (v-SNARE) with acyltransferase activity |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| MDY2 |
YOL111C |
Protein involved in inserting tail-anchored proteins into ER membranes |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| SDS22 |
YKL193C |
Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| ZEO1 |
YOL109W |
Peripheral membrane protein of the plasma membrane |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| COF1 |
YLL050C |
Cofilin, involved in pH-dependent actin filament depolarization |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| CAP1 |
YKL007W |
Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p) |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| PDI1 |
YCL043C |
Protein disulfide isomerase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| CYS3 |
YAL012W |
Cystathionine gamma-lyase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| GLK1 |
YCL040W |
Glucokinase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| HSP42 |
YDR171W |
Small heat shock protein (sHSP) with chaperone activity |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| GVP36 |
YIL041W |
BAR domain protein that localizes to early and late Golgi vesicles |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| PGM2 |
YMR105C |
Phosphoglucomutase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| VPS13 |
YLL040C |
Lipid transport protein involved in prospore membrane morphogenesis |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| CAP2 |
YIL034C |
Beta subunit of the capping protein heterodimer (Cap1p and Cap2p) |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| CAP2 |
YIL034C |
Beta subunit of the capping protein heterodimer (Cap1p and Cap2p) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| HIS4 |
YCL030C |
Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| YHB1 |
YGR234W |
Nitric oxide oxidoreductase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| GCS1 |
YDL226C |
ADP-ribosylation factor GTPase activating protein (ARF GAP) |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| GLR1 |
YPL091W |
Cytosolic and mitochondrial glutathione oxidoreductase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| YNL134C |
YNL134C |
NADH-dependent aldehyde reductase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| RNR1 |
YER070W |
Major isoform of large subunit of ribonucleotide-diphosphate reductase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| UBX5 |
YDR330W |
UBX domain-containing protein that interacts with Cdc48p |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| SSA2 |
YLL024C |
HSP70 family ATP-binding protein |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| NFS1 |
YCL017C |
Cysteine desulfurase involved in iron-sulfur cluster biogenesis |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| VMA2 |
YBR127C |
Subunit B of V1 peripheral membrane domain of vacuolar H+-ATPase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| CUE1 |
YMR264W |
Ubiquitin-binding protein |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| TPS1 |
YBR126C |
Synthase subunit of trehalose-6-P synthase/phosphatase complex |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| CPS1 |
YJL172W |
Vacuolar carboxypeptidase S |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| CDC3 |
YLR314C |
Component of the septin ring that is required for cytokinesis |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| CDC3 |
YLR314C |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SIS1 |
YNL007C |
Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| HUG1 |
YML058W-A |
Ribonucleotide reductase inhibitor |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| FAA1 |
YOR317W |
Long chain fatty acyl-CoA synthetase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| RVS167 |
YDR388W |
Calmodulin-binding actin-associated protein |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| HSP26 |
YBR072W |
Small heat shock protein (sHSP) with chaperone activity |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| WWM1 |
YFL010C |
WW domain containing protein of unknown function |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| HSP12 |
YFL014W |
Plasma membrane protein involved in maintaining membrane organization |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| SOD1 |
YJR104C |
Cytosolic copper-zinc superoxide dismutase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| SOD1 |
YJR104C |
Cytosolic copper-zinc superoxide dismutase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| DMA1 |
YHR115C |
Ubiquitin-protein ligase (E3) |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| DMA2 |
YNL116W |
Ubiquitin-protein ligase (E3) |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BOI2 |
YER114C |
Protein involved in polar growth |
physical |
1 |
1 |
1 |
PCA |
| CHC1 |
YGL206C |
Clathrin heavy chain |
physical |
1 |
1 |
1 |
PCA |
| CNB1 |
YKL190W |
Calcineurin B |
physical |
1 |
1 |
1 |
PCA |
| CRM1 |
YGR218W |
Nuclear export factor, exportin |
physical |
1 |
1 |
1 |
PCA |
| EXO70 |
YJL085W |
Subunit of the exocyst complex |
physical |
1 |
1 |
1 |
PCA |
| MLC1 |
YGL106W |
Essential light chain for Myo1p |
physical |
1 |
1 |
1 |
PCA |
| OSH6 |
YKR003W |
Oxysterol-binding phosphatidylserine transferase |
physical |
1 |
1 |
1 |
PCA |
| SEC5 |
YDR166C |
Essential 107kDa subunit of the exocyst complex |
physical |
1 |
1 |
1 |
PCA |
| SEC8 |
YPR055W |
Essential 121 kDa subunit of the exocyst complex |
physical |
1 |
1 |
1 |
PCA |
| SHE2 |
YKL130C |
RNA-binding protein that binds specific mRNAs and interacts with She3p |
physical |
1 |
1 |
1 |
PCA |
| RPS2 |
YGL123W |
Protein component of the small (40S) subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS9A |
YPL081W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS3 |
YNL178W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| VID22 |
YLR373C |
G-quadruplex (G4) DNA binding protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CIN8 |
YEL061C |
Bipolar kinesin motor protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RAS2 |
YNL098C |
GTP-binding protein |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| STE12 |
YHR084W |
Transcription factor that is activated by a MAPK signaling cascade |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| MAD2 |
YJL030W |
Component of the spindle-assembly checkpoint complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| BUB3 |
YOR026W |
Kinetochore checkpoint WD40 repeat protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CDC34 |
YDR054C |
Ubiquitin-conjugating enzyme (E2) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| RGA1 |
YOR127W |
GTPase-activating protein for polarity-regulator Cdc42p (RhoGAP) |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| ICE2 |
YIL090W |
Integral ER membrane protein with type-III transmembrane domains |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| UFO1 |
YML088W |
F-box receptor protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MNN11 |
YJL183W |
Subunit of a Golgi mannosyltransferase complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| URM1 |
YIL008W |
Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| CLN2 |
YPL256C |
G1 cyclin involved in regulation of the cell cycle |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| CLN1 |
YMR199W |
G1 cyclin involved in regulation of the cell cycle |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| SIR2 |
YDL042C |
Conserved NAD+ dependent histone deacetylase of the Sirtuin family |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| ECM33 |
YBR078W |
GPI-anchored protein involved in efficient glucose uptake |
genetic |
1 |
1 |
1 |
Negative Genetic |
| STE50 |
YCL032W |
Adaptor protein for various signaling pathways |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MRPL1 |
YDR116C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS72 |
YDR485C |
Htz1p-binding component of the SWR1 complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| FIS1 |
YIL065C |
Protein involved in mitochondrial fission and peroxisome abundance |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HOC1 |
YJR075W |
Alpha-1,6-mannosyltransferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| DPH2 |
YKL191W |
Protein required for synthesis of diphthamide |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RSC2 |
YLR357W |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MDM12 |
YOL009C |
Mitochondrial outer membrane protein, ERMES complex subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YME1 |
YPR024W |
Catalytic subunit of i-AAA protease complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS54 |
YDR027C |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| PEP8 |
YJL053W |
Vacuolar protein component of the retromer |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| TPM2 |
YIL138C |
Minor isoform of tropomyosin |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| GIC1 |
YHR061C |
Rho-family GTPase interacting protein and Cdc42p effector |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| HNT3 |
YOR258W |
DNA 5' AMP hydrolase involved in DNA repair |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| DCC1 |
YCL016C |
Subunit of a complex with Ctf8p and Ctf18p |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SAC3 |
YDR159W |
mRNA export factor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MDM20 |
YOL076W |
Non-catalytic subunit of the NatB N-terminal acetyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| TIP41 |
YPR040W |
Tap42p-interacting protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| LDB19 |
YOR322C |
Alpha-arrestin, Ub-ligase adaptor for Rsp5p |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| VPS51 |
YKR020W |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RPN10 |
YHR200W |
Proteasome polyubiquitin receptor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SYS1 |
YJL004C |
Integral membrane protein of the Golgi |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| VAC7 |
YNL054W |
Integral vacuolar membrane protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| IRC6 |
YFR043C |
Clathrin coat accessory factor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MNN2 |
YBR015C |
Alpha-1,2-mannosyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| YPT31 |
YER031C |
Rab family GTPase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| GTR1 |
YML121W |
Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| OST3 |
YOR085W |
Gamma subunit of the oligosaccharyltransferase complex of the ER lumen |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| INP53 |
YOR109W |
Polyphosphatidylinositol phosphatase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| COG5 |
YNL051W |
Component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| COG7 |
YGL005C |
Component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| COG8 |
YML071C |
Component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| ERG5 |
YMR015C |
C-22 sterol desaturase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| BRX1 |
YOL077C |
Nucleolar protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| COP1 |
YDL145C |
Alpha subunit of COPI vesicle coatomer complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| DRS1 |
YLL008W |
Nucleolar DEAD-box protein required for ribosome assembly and function |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| PLP2 |
YOR281C |
Protein that interacts with the CCT complex to stimulate actin folding |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RER2 |
YBR002C |
Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1 |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SEC10 |
YLR166C |
Essential 100kDa subunit of the exocyst complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SRP72 |
YPL210C |
Core component of the signal recognition particle (SRP) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| CDC19 |
YAL038W |
Pyruvate kinase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CFD1 |
YIL003W |
Highly conserved iron-sulfur cluster binding protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| COG4 |
YPR105C |
Essential component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| DPM1 |
YPR183W |
Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ERG1 |
YGR175C |
Squalene epoxidase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| GRC3 |
YLL035W |
Polynucleotide kinase present on rDNA |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MAK16 |
YAL025C |
Essential nuclear protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| NAN1 |
YPL126W |
U3 snoRNP protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| NOP7 |
YGR103W |
Component of several different pre-ribosomal particles |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| POP1 |
YNL221C |
Subunit of RNase MRP, nuclear RNase P and telomerase complexes |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RFT1 |
YBL020W |
Membrane protein required for translocation of Man5GlcNac2-PP-Dol |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SDA1 |
YGR245C |
Protein required for actin organization and passage through Start |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SEC11 |
YIR022W |
18kDa catalytic subunit of the Signal Peptidase Complex (SPC) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SEC15 |
YGL233W |
Essential 113 kDa subunit of the exocyst complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SEN34 |
YAR008W |
Subunit of the tRNA splicing endonuclease |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SMX2 |
YFL017W-A |
Core Sm protein Sm G |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SSU72 |
YNL222W |
Phosphatase and transcription/RNA-processing factor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| THS1 |
YIL078W |
Threonyl-tRNA synthetase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| UTP15 |
YMR093W |
Nucleolar protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| UTP20 |
YBL004W |
Component of the small-subunit (SSU) processome |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| UTP22 |
YGR090W |
Component of the small-subunit processome |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| UTP4 |
YDR324C |
Subunit of U3-containing 90S preribosome and SSU processome complexes |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| UTP9 |
YHR196W |
Nucleolar protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PGA1 |
YNL158W |
Essential component of GPI-mannosyltransferase II |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RHO4 |
YKR055W |
Non-essential small GTPase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| ISC1 |
YER019W |
Inositol phosphosphingolipid phospholipase C |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| TTI2 |
YJR136C |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KEL1 |
YHR158C |
Protein required for proper cell fusion and cell morphology |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| KEL2 |
YGR238C |
Protein that negatively regulates mitotic exit |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SPC110 |
YDR356W |
Inner plaque spindle pole body (SPB) component |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MNN10 |
YDR245W |
Subunit of a Golgi mannosyltransferase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| VPS29 |
YHR012W |
Subunit of the membrane-associated retromer complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CDC24 |
YAL041W |
Guanine nucleotide exchange factor (GEF) for Cdc42p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| QRI1 |
YDL103C |
UDP-N-acetylglucosamine pyrophosphorylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NOP14 |
YDL148C |
Nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MSS4 |
YDR208W |
Phosphatidylinositol-4-phosphate 5-kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TRS23 |
YDR246W |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
1 |
1 |
1 |
Negative Genetic |
| COG3 |
YER157W |
Essential component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GNA1 |
YFL017C |
Glucosamine-6-phosphate acetyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NUP57 |
YGR119C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YHR020W |
YHR020W |
Prolyl-tRNA synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC12 |
YHR107C |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ERG9 |
YHR190W |
Farnesyl-diphosphate farnesyl transferase (squalene synthase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC11 |
YJR076C |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TOR2 |
YKL203C |
PIK-related protein kinase and rapamycin target |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRP19 |
YLL036C |
Splicing factor associated with the spliceosome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ERO1 |
YML130C |
Thiol oxidase required for oxidative protein folding in the ER |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LCB1 |
YMR296C |
Component of serine palmitoyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TED1 |
YIL039W |
GPI-glycan remodelase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PFA4 |
YOL003C |
Palmitoyltransferase with autoacylation activity |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BUB1 |
YGR188C |
Protein kinase involved in the cell cycle checkpoint into anaphase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| INO4 |
YOL108C |
Transcription factor involved in phospholipid synthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TUB2 |
YFL037W |
Beta-tubulin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TUM1 |
YOR251C |
Rhodanese domain sulfur transferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CPR3 |
YML078W |
Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SLX8 |
YER116C |
Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| VPS53 |
YJL029C |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PPH21 |
YDL134C |
Catalytic subunit of protein phosphatase 2A, PP2A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MID2 |
YLR332W |
O-glycosylated plasma membrane protein |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| SCS22 |
YBL091C-A |
Protein involved in regulation of phospholipid metabolism |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ARP8 |
YOR141C |
Nuclear actin-related protein involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Positive Genetic |
| APM1 |
YPL259C |
Mu1-like medium subunit of the AP-1 complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| ADE57 |
YGL234W |
Bifunctional enzyme of 'de novo' purine nucleotide pathway |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| ATP2 |
YJR121W |
Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| BBC1 |
YJL020C |
Protein possibly involved in assembly of actin patches |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| AHP1 |
YLR109W |
Thiol-specific peroxiredoxin |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| AXL1 |
YPR122W |
Haploid specific endoprotease of a-factor mating pheromone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AIP1 |
YMR092C |
Actin cortical patch component |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| ADE17 |
YMR120C |
Enzyme of 'de novo' purine biosynthesis |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| AIP5 |
YFR016C |
Protein that positively regulates actin assembly |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| BIL2 |
YGL015C |
Formin inhibitor |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ACA1 |
YER045C |
ATF/CREB family basic leucine zipper (bZIP) transcription factor |
physical |
1 |
1 |
1 |
Two-hybrid |
| AIM7 |
YDR063W |
Protein that interacts with Arp2/3 complex |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| ASK10 |
YGR097W |
Regulator of the Fps1p glycerol channel |
genetic |
1 |
1 |
1 |
Positive Genetic |
| AIM4 |
YBR194W |
Protein proposed to be associated with the nuclear pore complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| ALG5 |
YPL227C |
UDP-glucose:dolichyl-phosphate glucosyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| ARL3 |
YPL051W |
ARF-like small GTPase of the RAS superfamily |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| ATP16 |
YDL004W |
Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| BIL1 |
YOR304C-A |
Protein that binds Bud6p and has a role in actin cable assembly |
physical |
1 |
1 |
1 |
PCA |
| AGE2 |
YIL044C |
ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| ALG6 |
YOR002W |
ER-luminal alpha 1,3 glucosyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| ARF3 |
YOR094W |
Glucose-repressible ADP-ribosylation factor |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| ALG8 |
YOR067C |
Glucosyl transferase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| AIM33 |
YML087C |
Protein of unknown function, highly conserved across species |
genetic |
1 |
1 |
1 |
Negative Genetic |
