Standard name Systematic name Name description Description
ZDS2 YML109W Protein with a role in regulating Swe1p-dependent polarized growth Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication
Visualize the interactome of ZDS2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1/S 43

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.921 NaN 0.964
Mito NaN NaN 0.073

GFP localization & abundance

GFP localization GFP abundance
cytoplasm 105

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
ZDS2 0 3 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
ZDS1 YMR273C Protein with a role in regulating Swe1p-dependent polarized growth genetic 13 3 12 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Negative Genetic
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) physical 11 3 8 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western
TPD3 YAL016W Regulatory subunit A of the heterotrimeric PP2A complex physical 7 3 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Two-hybrid
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 4 3 3 Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Synthetic Growth Defect
BOI1 YBL085W Protein involved in polar growth, functionally redundant with Boi2p physical 3 1 3 Two-hybrid, Two-hybrid, Two-hybrid
PKC1 YBL105C Protein serine/threonine kinase physical 3 1 3 Two-hybrid, Two-hybrid, Two-hybrid
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
IGO2 YHR132W-A Protein required for initiation of G0 program genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails physical 3 3 1 Two-hybrid, Reconstituted Complex, Affinity Capture-Western
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 2 2 2 Dosage Rescue, Synthetic Rescue
PPH21 YDL134C Catalytic subunit of protein phosphatase 2A, PP2A physical 2 2 2 Affinity Capture-MS, Two-hybrid
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains physical 2 2 2 Two-hybrid, Reconstituted Complex
BOI2 YER114C Protein involved in polar growth physical 2 1 2 Two-hybrid, Two-hybrid
CEG1 YGL130W Guanylyltransferase involved in mRNA 5' capping genetic 2 1 2 Dosage Rescue, Dosage Rescue
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
PPH22 YDL188C Catalytic subunit of protein phosphatase 2A, PP2A physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RHO1 YPR165W GTP-binding protein of the rho subfamily of Ras-like proteins physical 2 1 2 Two-hybrid, Two-hybrid
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 2 1 2 Phenotypic Suppression, Phenotypic Suppression
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 2 2 1 Phenotypic Enhancement, Phenotypic Suppression
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 2 2 1 Positive Genetic, Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 2 2 1 Positive Genetic, Negative Genetic
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 2 1 1 Dosage Lethality, Dosage Lethality
ZDS1 YMR273C Protein with a role in regulating Swe1p-dependent polarized growth physical 2 1 1 Two-hybrid, Two-hybrid
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TUP1 YCR084C General repressor of transcription in complex with Cyc8p regulation 1 1 1 DNA to cDNA expression microarray evidence
CKA2 YOR061W Alpha' catalytic subunit of casein kinase 2 (CK2) genetic 1 1 1 Dosage Rescue
RPB2 YOR151C RNA polymerase II second largest subunit B150 genetic 1 1 1 Negative Genetic
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
RPF1 YHR088W Protein involved in assembly and export of the large ribosomal subunit genetic 1 1 1 Negative Genetic
CDC42 YLR229C Small rho-like GTPase genetic 1 1 1 Dosage Rescue
RRP14 YKL082C Essential protein, constituent of 66S pre-ribosomal particles physical 1 1 1 Two-hybrid
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor physical 1 1 1 Two-hybrid
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Dosage Rescue
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
CFT2 YLR115W Subunit of the mRNA cleavage and polyadenlylation factor (CPF) genetic 1 1 1 Negative Genetic
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
BEM1 YBR200W Protein containing SH3-domains genetic 1 1 1 Negative Genetic
BET2 YPR176C Beta subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 1 1 1 Phenotypic Suppression
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 Two-hybrid
CDC11 YJR076C Component of the septin ring that is required for cytokinesis physical 1 1 1 Two-hybrid
BNI1 YNL271C Formin physical 1 1 1 Two-hybrid
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
MCD1 YDL003W Essential alpha-kleisin subunit of the cohesin complex genetic 1 1 1 Dosage Rescue
MED11 YMR112C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member genetic 1 1 1 Negative Genetic
BLM10 YFL007W Proteasome activator physical 1 1 1 Affinity Capture-MS
RFC2 YJR068W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
SIF2 YBR103W WD40 repeat-containing subunit of Set3C histone deacetylase complex physical 1 1 1 Affinity Capture-MS
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family physical 1 1 1 Two-hybrid
SLA1 YBL007C Cytoskeletal protein binding protein physical 1 1 1 Two-hybrid
SMD1 YGR074W Core Sm protein Sm D1 genetic 1 1 1 Negative Genetic
TAF6 YGL112C Subunit (60 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 1 1 1 Synthetic Growth Defect
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Negative Genetic
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Dosage Rescue
AAT2 YLR027C Cytosolic aspartate aminotransferase involved in nitrogen metabolism genetic 1 1 1 Negative Genetic
CHK1 YBR274W Serine/threonine kinase and DNA damage checkpoint effector genetic 1 1 1 Phenotypic Enhancement
YEL023C YEL023C Putative protein of unknown function physical 1 1 1 Two-hybrid
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
RHO1 YPR165W GTP-binding protein of the rho subfamily of Ras-like proteins genetic 1 1 1 Phenotypic Suppression
OCA1 YNL099C Putative protein tyrosine phosphatase genetic 1 1 1 Positive Genetic
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 1 1 1 Dosage Rescue
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 1 1 1 Synthetic Growth Defect
RVS167 YDR388W Calmodulin-binding actin-associated protein physical 1 1 1 Two-hybrid
BEM3 YPL115C Rho GTPase activating protein (RhoGAP) physical 1 1 1 Two-hybrid
HIR1 YBL008W Subunit of the HIR complex genetic 1 1 1 Negative Genetic
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network genetic 1 1 1 Synthetic Growth Defect
MIH1 YMR036C Protein tyrosine phosphatase genetic 1 1 1 Phenotypic Suppression
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 1 1 1 Dosage Rescue
PRS5 YOL061W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase genetic 1 1 1 Positive Genetic
IGO1 YNL157W Protein required for initiation of G0 program genetic 1 1 1 Synthetic Growth Defect
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Positive Genetic
SIR3 YLR442C Silencing protein physical 1 1 1 Two-hybrid
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway physical 1 1 1 Two-hybrid
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I physical 1 1 1 Two-hybrid
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
HSP10 YOR020C Mitochondrial matrix co-chaperonin genetic 1 1 1 Negative Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Negative Genetic
URE2 YNL229C Nitrogen catabolite repression transcriptional regulator genetic 1 1 1 Negative Genetic
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 1 1 1 Positive Genetic
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family genetic 1 1 1 Synthetic Lethality
MYO5 YMR109W One of two type I myosin motors physical 1 1 1 Two-hybrid
OST2 YOR103C Epsilon subunit of the oligosaccharyltransferase complex genetic 1 1 1 Negative Genetic
SEC61 YLR378C Conserved ER protein translocation channel genetic 1 1 1 Negative Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci physical 1 1 1 Two-hybrid
TIM22 YDL217C Essential core component of mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
HSF1 YGL073W Trimeric heat shock transcription factor genetic 1 1 1 Dosage Rescue
GAL80 YML051W Transcriptional regulator involved in the repression of GAL genes genetic 1 1 1 Negative Genetic
GIC1 YHR061C Rho-family GTPase interacting protein and Cdc42p effector physical 1 1 1 Two-hybrid
DSE1 YER124C Daughter cell-specific protein physical 1 1 1 Two-hybrid
GIC2 YDR309C Rho-family GTPase interacting protein and Cdc42p effector physical 1 1 1 Two-hybrid
CLA4 YNL298W Cdc42p-activated signal transducing kinase physical 1 1 1 Two-hybrid
SKG6 YHR149C Integral membrane protein physical 1 1 1 Two-hybrid
SPR6 YER115C Protein of unknown function physical 1 1 1 Two-hybrid
ZDS2 YML109W Protein with a role in regulating Swe1p-dependent polarized growth physical 1 1 1 Two-hybrid
TAO3 YIL129C Component of the RAM signaling network genetic 1 1 1 Negative Genetic
OKP1 YGR179C Outer kinetochore protein required for accurate chromosome segregation physical 1 1 1 Two-hybrid
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 1 1 1 Negative Genetic
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Positive Genetic
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
YML131W YML131W Protein of unknown function physical 1 1 1 Affinity Capture-MS
ROT1 YMR200W Molecular chaperone involved in protein folding in ER genetic 1 1 1 Negative Genetic
NUP192 YJL039C Essential subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
PTK2 YJR059W Serine/threonine protein kinase genetic 1 1 1 Positive Genetic
CDC1 YDR182W Putative mannose-ethanolamine phosphate phosphodiesterase genetic 1 1 1 Negative Genetic
VAC7 YNL054W Integral vacuolar membrane protein genetic 1 1 1 Negative Genetic
ZAP1 YJL056C Zinc-regulated transcription factor genetic 1 1 1 Negative Genetic
WAR1 YML076C Homodimeric Zn2Cys6 zinc finger transcription factor genetic 1 1 1 Negative Genetic