Standard name Systematic name Name description Description
CLA4 YNL298W Cdc42p-activated signal transducing kinase Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication
Visualize the interactome of CLA4
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1(P) 21

CYCLoPs localization & abundance

WT1 WT2 WT3
Bud 0.158 0.195 0.165
Budsite 0.108 0.105 0.083
Cort. Patches 0.146 0.193 0.162
Cytoplasm 0.589 0.570 0.598
Endosome 0.051 NaN NaN
SpindlePole 0.082 0.088 0.134
Cell Periphery NaN NaN 0.060
Vac/Vac Memb NaN NaN 0.054

GFP localization & abundance

GFP localization GFP abundance
ambiguous, cytoplasm, cell periphery, bud low signal

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
CLA4 2 1 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
STE20 YHL007C Cdc42p-activated signal transducing kinase genetic 13 5 13 Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Phenotypic Enhancement
CDC42 YLR229C Small rho-like GTPase physical 11 4 11 Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, FRET
CDC42 YLR229C Small rho-like GTPase genetic 11 6 10 Synthetic Lethality, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Suppression, Dosage Rescue, Synthetic Lethality, Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Phenotypic Suppression, Negative Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 10 4 9 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Positive Genetic, Negative Genetic, Negative Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 9 2 9 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 9 2 9 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
CHS3 YBR023C Chitin synthase III genetic 9 3 8 Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 9 3 8 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
CHS6 YJL099W Member of the ChAPs (Chs5p-Arf1p-binding proteins) family genetic 9 3 8 Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 9 2 7 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 8 4 8 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Dosage Growth Defect, Negative Genetic
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 8 2 8 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component genetic 8 2 8 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
SLK19 YOR195W Kinetochore-associated protein genetic 8 2 8 Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 8 2 8 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 8 3 7 Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
CHS5 YLR330W Component of the exomer complex genetic 8 3 7 Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 8 2 7 Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SKT5 YBL061C Activator of Chs3p (chitin synthase III) during vegetative growth genetic 8 4 6 Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Dosage Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 8 3 6 Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Dosage Growth Defect, Negative Genetic, Negative Genetic
SPA2 YLL021W Component of the polarisome genetic 7 3 7 Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 7 2 7 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
HSL1 YKL101W Nim1p-related protein kinase genetic 7 2 7 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 7 2 7 Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BEM1 YBR200W Protein containing SH3-domains genetic 7 4 6 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Rescue, Synthetic Lethality, Negative Genetic, Dosage Growth Defect
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 7 3 6 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase genetic 7 3 6 Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
SMY1 YKL079W Kinesin-like myosin passenger-protein genetic 7 3 6 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Dosage Growth Defect, Negative Genetic, Negative Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 7 3 6 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
RAD51 YER095W Strand exchange protein genetic 7 3 6 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Positive Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 7 2 6 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BNI1 YNL271C Formin genetic 7 2 4 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Synthetic Lethality
PEA2 YER149C Coiled-coil 12S polarisome subunit genetic 6 4 6 Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
BUD6 YLR319C Actin- and formin-interacting protein genetic 6 3 6 Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
APC9 YLR102C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 6 2 6 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
EDE1 YBL047C Scaffold protein involved in the formation of early endocytic sites genetic 6 2 6 Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 6 2 6 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
SGF11 YPL047W Integral subunit of SAGA histone acetyltransferase complex genetic 6 2 6 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway physical 6 5 5 Two-hybrid, Affinity Capture-MS, PCA, Reconstituted Complex, Protein-peptide, Protein-peptide
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 6 4 5 Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Positive Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 6 3 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
RAD52 YML032C Protein involved in homologous recombination genetic 6 3 5 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Positive Genetic
CHS7 YHR142W Protein of unknown function genetic 6 3 5 Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic
SWI6 YLR182W Transcription cofactor genetic 6 2 5 Negative Genetic, Negative Genetic, Negative Genetic, Dosage Growth Defect, Negative Genetic, Negative Genetic
BEM1 YBR200W Protein containing SH3-domains physical 5 4 5 Affinity Capture-Western, Two-hybrid, PCA, Protein-peptide, Protein-peptide
FKH2 YNL068C Forkhead family transcription factor genetic 5 4 5 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Dosage Growth Defect
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 5 4 5 Synthetic Lethality, Phenotypic Enhancement, Dosage Lethality, Negative Genetic, Negative Genetic
ASF1 YJL115W Nucleosome assembly factor genetic 5 3 5 Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
RGA1 YOR127W GTPase-activating protein for polarity-regulator Cdc42p (RhoGAP) genetic 5 3 5 Synthetic Growth Defect, Dosage Rescue, Negative Genetic, Negative Genetic, Negative Genetic
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 5 3 5 Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression
ELP2 YGR200C Subunit of Elongator complex genetic 5 3 5 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
ELP6 YMR312W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 5 3 5 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 5 3 5 Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Dosage Growth Defect
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 5 2 5 Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
BEM4 YPL161C Protein involved in establishment of cell polarity and bud emergence genetic 5 2 5 Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 5 2 5 Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 5 2 5 Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 5 1 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SLA1 YBL007C Cytoskeletal protein binding protein genetic 5 1 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 5 1 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p physical 5 4 4 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Biochemical Activity, Two-hybrid
CTF4 YPR135W Chromatin-associated protein genetic 5 3 4 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect
AIM44 YPL158C Regulator of Cdc42p and Rho1p genetic 5 3 4 Positive Genetic, Positive Genetic, Synthetic Rescue, Dosage Lethality, Positive Genetic
ARP2 YDL029W Essential component of the Arp2/3 complex genetic 4 3 4 Synthetic Lethality, Phenotypic Enhancement, Synthetic Lethality, Negative Genetic
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 4 3 4 Dosage Rescue, Dosage Rescue, Negative Genetic, Positive Genetic
UBA4 YHR111W E1-like protein that activates Urm1p before urmylation genetic 4 2 4 Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect
SPO12 YHR152W Nucleolar protein of unknown function genetic 4 2 4 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 4 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality
VAC14 YLR386W Enzyme regulator genetic 4 2 4 Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle genetic 4 2 4 Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 4 2 4 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 4 2 4 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
RTS1 YOR014W B-type regulatory subunit of protein phosphatase 2A (PP2A) genetic 4 2 4 Synthetic Rescue, Positive Genetic, Synthetic Rescue, Positive Genetic
SAC3 YDR159W mRNA export factor genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
MSN5 YDR335W Karyopherin genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
YCK3 YER123W Palmitoylated vacuolar membrane-localized casein kinase I isoform genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SAP185 YJL098W Protein that forms a complex with the Sit4p protein phosphatase genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
AXL2 YIL140W Integral plasma membrane protein genetic 4 3 3 Phenotypic Enhancement, Negative Genetic, Dosage Growth Defect, Negative Genetic
DMA2 YNL116W Ubiquitin-protein ligase (E3) genetic 4 3 3 Synthetic Lethality, Dosage Lethality, Negative Genetic, Synthetic Lethality
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 4 3 3 Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 4 3 3 Synthetic Lethality, Synthetic Lethality, Dosage Growth Defect, Negative Genetic
RAD55 YDR076W Protein that stimulates strand exchange genetic 4 3 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Positive Genetic
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 4 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality
CDC14 YFR028C Protein phosphatase required for mitotic exit genetic 3 3 3 Dosage Lethality, Synthetic Growth Defect, Negative Genetic
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 3 3 3 Synthetic Lethality, Dosage Growth Defect, Negative Genetic
BIM1 YER016W Microtubule plus end-tracking protein genetic 3 3 3 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
HSP82 YPL240C Hsp90 chaperone genetic 3 3 3 Synthetic Lethality, Synthetic Growth Defect, Phenotypic Suppression
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia genetic 3 3 3 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
RTT106 YNL206C Histone chaperone genetic 3 3 3 Synthetic Lethality, Synthetic Growth Defect, Dosage Growth Defect
RPL23A YBL087C Ribosomal 60S subunit protein L23A genetic 3 3 3 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
GIN4 YDR507C Protein kinase involved in bud growth and assembly of the septin ring genetic 3 3 3 Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Lethality
PFY1 YOR122C Profilin genetic 3 3 3 Dosage Growth Defect, Synthetic Growth Defect, Negative Genetic
CIN8 YEL061C Bipolar kinesin motor protein genetic 3 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic
CAK1 YFL029C Cyclin-dependent kinase-activating kinase genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
HHF1 YBR009C Histone H4 physical 3 2 3 Affinity Capture-MS, Biochemical Activity, Biochemical Activity
ITC1 YGL133W Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex genetic 3 2 3 Synthetic Lethality, Negative Genetic, Synthetic Lethality
MGA2 YIR033W ER membrane protein involved in regulation of OLE1 transcription genetic 3 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic
RIM20 YOR275C Protein involved in proteolytic activation of Rim101p genetic 3 2 3 Synthetic Lethality, Synthetic Lethality, Dosage Growth Defect
RPL35A YDL191W Ribosomal 60S subunit protein L35A genetic 3 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
ERG5 YMR015C C-22 sterol desaturase genetic 3 2 3 Phenotypic Enhancement, Negative Genetic, Negative Genetic
CLN3 YAL040C G1 cyclin involved in cell cycle progression genetic 3 2 3 Negative Genetic, Negative Genetic, Dosage Growth Defect
KIN4 YOR233W Serine/threonine protein kinase genetic 3 2 3 Positive Genetic, Positive Genetic, Synthetic Rescue
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
RAD57 YDR004W Protein that stimulates strand exchange genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome genetic 3 2 3 Negative Genetic, Dosage Growth Defect, Negative Genetic
RPT2 YDL007W ATPase of the 19S regulatory particle of the 26S proteasome genetic 3 2 3 Negative Genetic, Dosage Growth Defect, Negative Genetic
CAP1 YKL007W Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CHL1 YPL008W Probable DNA helicase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SSD1 YDR293C Translational repressor genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
MUM2 YBR057C Protein essential for meiotic DNA replication and sporulation genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CYK3 YDL117W SH3-domain protein located in the bud neck and cytokinetic actin ring genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
FYV8 YGR196C Protein of unknown function genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CSI2 YOL007C Protein of unknown function genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
POC4 YPL144W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
THP3 YPR045C Protein that may have a role in transcription elongation genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CAP2 YIL034C Beta subunit of the capping protein heterodimer (Cap1p and Cap2p) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
GIC1 YHR061C Rho-family GTPase interacting protein and Cdc42p effector genetic 3 3 2 Phenotypic Suppression, Phenotypic Enhancement, Dosage Growth Defect
GIC2 YDR309C Rho-family GTPase interacting protein and Cdc42p effector genetic 3 3 2 Phenotypic Suppression, Phenotypic Enhancement, Dosage Growth Defect
BUB2 YMR055C Mitotic exit network regulator genetic 3 2 2 Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Negative Genetic
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 3 2 2 Negative Genetic, Synthetic Lethality, Synthetic Lethality
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 3 2 2 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
MPH1 YIR002C 3'-5' DNA helicase involved in error-free bypass of DNA lesions genetic 3 2 2 Negative Genetic, Negative Genetic, Positive Genetic
ACS2 YLR153C Acetyl-coA synthetase isoform genetic 3 1 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
SHS1 YDL225W Component of the septin ring that is required for cytokinesis genetic 3 1 2 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
VAC17 YCL063W Phosphoprotein involved in vacuole inheritance physical 3 3 1 Reconstituted Complex, Biochemical Activity, Co-localization
BRE1 YDL074C E3 ubiquitin ligase genetic 2 2 2 Negative Genetic, Synthetic Lethality
BMH1 YER177W 14-3-3 protein, major isoform genetic 2 2 2 Positive Genetic, Dosage Growth Defect
ARC35 YNR035C Subunit of the ARP2/3 complex genetic 2 2 2 Dosage Growth Defect, Negative Genetic
BMH2 YDR099W 14-3-3 protein, minor isoform genetic 2 2 2 Positive Genetic, Dosage Growth Defect
CDC10 YCR002C Component of the septin ring, required for cytokinesis genetic 2 2 2 Dosage Growth Defect, Negative Genetic
CDC12 YHR107C Component of the septin ring that is required for cytokinesis physical 2 2 2 Two-hybrid, Biochemical Activity
BUD3 YCL014W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 2 2 2 Phenotypic Enhancement, Dosage Growth Defect
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 2 2 2 Negative Genetic, Dosage Growth Defect
CDC5 YMR001C Polo-like kinase required for mitotic exit genetic 2 2 2 Dosage Lethality, Synthetic Growth Defect
BEM3 YPL115C Rho GTPase activating protein (RhoGAP) genetic 2 2 2 Dosage Rescue, Dosage Growth Defect
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network genetic 2 2 2 Dosage Lethality, Negative Genetic
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 2 2 2 Dosage Growth Defect, Negative Genetic
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 2 2 2 Dosage Rescue, Negative Genetic
BUD4 YJR092W Anillin-like protein involved in bud-site selection genetic 2 2 2 Phenotypic Enhancement, Dosage Growth Defect
BNR1 YIL159W Formin genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
AKR1 YDR264C Palmitoyl transferase involved in protein palmitoylation genetic 2 2 2 Synthetic Lethality, Negative Genetic
PTC1 YDL006W Type 2C protein phosphatase (PP2C) physical 2 2 2 Biochemical Activity, PCA
RAD53 YPL153C DNA damage response kinase genetic 2 2 2 Synthetic Growth Defect, Dosage Growth Defect
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 2 2 2 Negative Genetic, Dosage Growth Defect
RSC8 YFR037C Component of the RSC chromatin remodeling complex genetic 2 2 2 Dosage Growth Defect, Negative Genetic
DYN2 YDR424C Cytoplasmic light chain dynein, microtubule motor protein genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
RGA2 YDR379W GTPase-activating protein for polarity-establishment protein Cdc42p genetic 2 2 2 Synthetic Growth Defect, Dosage Growth Defect
NAP1 YKR048C Histone chaperone and assembly chaperone for Rps6a/b genetic 2 2 2 Synthetic Growth Defect, Dosage Growth Defect
URM1 YIL008W Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
DIA2 YOR080W Origin-binding F-box protein genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
RTT109 YLL002W Histone acetyltransferase genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
PAC11 YDR488C Dynein intermediate chain, microtubule motor protein genetic 2 2 2 Negative Genetic, Dosage Growth Defect
GET2 YER083C Subunit of the GET complex genetic 2 2 2 Negative Genetic, Positive Genetic
SEC14 YMR079W Phosphatidylinositol/phosphatidylcholine transfer protein genetic 2 2 2 Synthetic Lethality, Dosage Rescue
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 2 2 2 Synthetic Growth Defect, Phenotypic Suppression
RAM1 YDL090C Beta subunit of the CAAX farnesyltransferase (FTase) genetic 2 2 2 Negative Genetic, Dosage Growth Defect
SIW14 YNL032W Inositol phosphatase involved in inositol pyrophosphate metabolism genetic 2 2 2 Positive Genetic, Dosage Growth Defect
GAL83 YER027C One of three alternate beta-subunits of the Snf1 kinase complex genetic 2 2 2 Negative Genetic, Dosage Growth Defect
TCP1 YDR212W Alpha subunit of chaperonin-containing T-complex genetic 2 2 2 Synthetic Lethality, Positive Genetic
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) genetic 2 2 2 Dosage Rescue, Positive Genetic
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RAD18 YCR066W E3 ubiquitin ligase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CSM3 YMR048W Replication fork associated factor genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 2 2 2 Synthetic Growth Defect, Dosage Lethality
SHO1 YER118C Transmembrane osmosensor for filamentous growth and HOG pathways genetic 2 2 2 Negative Genetic, Dosage Growth Defect
MED7 YOL135C Subunit of the RNA polymerase II mediator complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 2 2 2 Negative Genetic, Dosage Growth Defect
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 2 2 2 Dosage Growth Defect, Negative Genetic
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 2 2 2 Dosage Growth Defect, Negative Genetic
CSE4 YKL049C Centromeric histone H3-like protein genetic 2 2 2 Dosage Growth Defect, Positive Genetic
NBP1 YLR457C Spindle pole body (SPB) component genetic 2 2 2 Dosage Growth Defect, Positive Genetic
SGT1 YOR057W Cochaperone protein genetic 2 2 2 Dosage Growth Defect, Positive Genetic
RAD61 YDR014W Subunit of a complex that inhibits sister chromatid cohesion genetic 2 2 2 Dosage Growth Defect, Negative Genetic
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 2 2 2 Negative Genetic, Synthetic Rescue
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) regulation 2 1 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence
CDC73 YLR418C Component of the Paf1p complex genetic 2 1 2 Negative Genetic, Negative Genetic
ARC40 YBR234C Subunit of the ARP2/3 complex genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
CDC3 YLR314C Component of the septin ring that is required for cytokinesis physical 2 1 2 Biochemical Activity, Biochemical Activity
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 2 1 2 Positive Genetic, Positive Genetic
RAD53 YPL153C DNA damage response kinase physical 2 1 2 Biochemical Activity, Biochemical Activity
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
NIP100 YPL174C Large subunit of the dynactin complex genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
RPL19A YBR084C-A Ribosomal 60S subunit protein L19A genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
RPL24A YGL031C Ribosomal 60S subunit protein L24A genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
RRD1 YIL153W Peptidyl-prolyl cis/trans-isomerase genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
URE2 YNL229C Nitrogen catabolite repression transcriptional regulator genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
NCS6 YGL211W Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
HOS4 YIL112W Subunit of the Set3 complex genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
NCS2 YNL119W Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
PHO85 YPL031C Cyclin-dependent kinase genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
RPS21B YJL136C Protein component of the small (40S) ribosomal subunit genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
DMA1 YHR115C Ubiquitin-protein ligase (E3) genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
RSC6 YCR052W Component of the RSC chromatin remodeling complex genetic 2 1 2 Negative Genetic, Negative Genetic
ISW2 YOR304W ATP-dependent DNA translocase involved in chromatin remodeling genetic 2 1 2 Negative Genetic, Negative Genetic
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 2 1 2 Negative Genetic, Negative Genetic
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) genetic 2 1 2 Negative Genetic, Negative Genetic
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 2 1 2 Negative Genetic, Negative Genetic
YVH1 YIR026C Dual specificity protein phosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
OCA2 YNL056W Protein of unknown function genetic 2 1 2 Positive Genetic, Positive Genetic
SSK1 YLR006C Cytoplasmic phosphorelay intermediate osmosensor and regulator genetic 2 1 2 Negative Genetic, Negative Genetic
MKK2 YPL140C MAPKK involved in the protein kinase C signaling pathway genetic 2 1 2 Negative Genetic, Negative Genetic
CTI6 YPL181W Component of the Rpd3L histone deacetylase complex genetic 2 1 2 Negative Genetic, Negative Genetic
HOM3 YER052C Aspartate kinase (L-aspartate 4-P-transferase) genetic 2 1 2 Negative Genetic, Negative Genetic
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
QCR9 YGR183C Subunit 9 of ubiquinol cytochrome-c reductase (Complex III) genetic 2 1 2 Negative Genetic, Negative Genetic
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 2 1 2 Negative Genetic, Negative Genetic
SNF6 YHL025W Subunit of the SWI/SNF chromatin remodeling complex genetic 2 1 2 Positive Genetic, Positive Genetic
POG1 YIL122W DNA-binding transcriptional activator genetic 2 1 2 Negative Genetic, Negative Genetic
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 2 1 2 Negative Genetic, Negative Genetic
RIM13 YMR154C Calpain-like cysteine protease genetic 2 1 2 Negative Genetic, Negative Genetic
TMA23 YMR269W Nucleolar protein implicated in ribosome biogenesis genetic 2 1 2 Negative Genetic, Negative Genetic
NOP12 YOL041C Nucleolar protein involved in pre-25S rRNA processing genetic 2 1 2 Negative Genetic, Negative Genetic
MDM12 YOL009C Mitochondrial outer membrane protein, ERMES complex subunit genetic 2 1 2 Negative Genetic, Negative Genetic
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain genetic 2 1 2 Negative Genetic, Negative Genetic
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex genetic 2 1 2 Negative Genetic, Negative Genetic
SYH1 YPL105C Protein of unknown function that influences nuclear pore distribution genetic 2 1 2 Negative Genetic, Negative Genetic
ELP4 YPL101W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 2 1 2 Negative Genetic, Negative Genetic
SUE1 YPR151C Protein required for degradation of unstable forms of cytochrome c genetic 2 1 2 Negative Genetic, Negative Genetic
RGD1 YBR260C GTPase-activating protein (RhoGAP) for Rho3p and Rho4p genetic 2 1 2 Negative Genetic, Negative Genetic
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 2 1 2 Negative Genetic, Negative Genetic
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway genetic 2 1 2 Negative Genetic, Negative Genetic
ELO3 YLR372W Elongase genetic 2 1 2 Negative Genetic, Negative Genetic
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 2 1 2 Negative Genetic, Negative Genetic
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 2 1 2 Negative Genetic, Negative Genetic
MOT3 YMR070W Transcriptional repressor, activator genetic 2 1 2 Negative Genetic, Negative Genetic
PSY3 YLR376C Component of Shu complex (aka PCSS complex) genetic 2 1 2 Negative Genetic, Negative Genetic
SHU1 YHL006C Component of Shu complex (aka PCSS complex) genetic 2 1 2 Negative Genetic, Negative Genetic
CSM2 YIL132C Subunit of the Shu complex (aka PCSS complex) genetic 2 1 2 Negative Genetic, Negative Genetic
SHU2 YDR078C Component of Shu complex (aka PCSS complex) genetic 2 1 2 Negative Genetic, Negative Genetic
RAD59 YDL059C Protein involved DNA double-strand break repair genetic 2 1 2 Negative Genetic, Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 2 1 2 Negative Genetic, Negative Genetic
PRE4 YFR050C Beta 7 subunit of the 20S proteasome genetic 2 1 2 Negative Genetic, Negative Genetic
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes genetic 2 1 2 Negative Genetic, Negative Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 2 1 2 Negative Genetic, Negative Genetic
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 2 1 2 Negative Genetic, Negative Genetic
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 2 Negative Genetic, Negative Genetic
PRE2 YPR103W Beta 5 subunit of the 20S proteasome genetic 2 1 2 Negative Genetic, Negative Genetic
PRE6 YOL038W Alpha 4 subunit of the 20S proteasome genetic 2 1 2 Negative Genetic, Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 2 Negative Genetic, Negative Genetic
PUP1 YOR157C Beta 2 subunit of the 20S proteasome genetic 2 1 2 Negative Genetic, Negative Genetic
ALD3 YMR169C Cytoplasmic aldehyde dehydrogenase regulation 2 2 1 chromatin immunoprecipitation-qPCR evidence, northern blot evidence
HSP12 YFL014W Plasma membrane protein involved in maintaining membrane organization regulation 2 2 1 chromatin immunoprecipitation-qPCR evidence, northern blot evidence
REI1 YBR267W Cytoplasmic pre-60S factor genetic 2 2 1 Phenotypic Enhancement, Synthetic Lethality
RSR1 YGR152C Ras-type GTPase genetic 2 2 1 Synthetic Growth Defect, Synthetic Rescue
CRH1 YGR189C Chitin transglycosylase genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
UTR2 YEL040W Chitin transglycosylase genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
RHO1 YPR165W GTP-binding protein of the rho subfamily of Ras-like proteins genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
ADA2 YDR448W Transcription coactivator genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
RQC2 YPL009C Component of the Ribosome Quality Control (RQC) complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
PIK1 YNL267W Phosphatidylinositol 4-kinase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
MPS3 YJL019W Nuclear envelope protein genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
STE12 YHR084W Transcription factor that is activated by a MAPK signaling cascade regulation 1 1 1 chromatin immunoprecipitation-chip evidence
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MSN2 YMR037C Stress-responsive transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit regulation 1 1 1 quantitative mass spectrometry evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UME6 YDR207C Rpd3L histone deacetylase complex subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SWI6 YLR182W Transcription cofactor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MBP1 YDL056W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MCM1 YMR043W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PUT3 YKL015W Transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HHF2 YNL030W Histone H4 regulation 1 1 1 protein kinase assay evidence
HHF1 YBR009C Histone H4 regulation 1 1 1 protein kinase assay evidence
BRX1 YOL077C Nucleolar protein genetic 1 1 1 Negative Genetic
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 1 1 1 Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
CFT2 YLR115W Subunit of the mRNA cleavage and polyadenlylation factor (CPF) genetic 1 1 1 Positive Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Synthetic Growth Defect
ARC15 YIL062C Subunit of the ARP2/3 complex genetic 1 1 1 Negative Genetic
ARC18 YLR370C Subunit of the ARP2/3 complex genetic 1 1 1 Negative Genetic
ARD1 YHR013C Subunit of protein N-terminal acetyltransferase NatA genetic 1 1 1 Synthetic Growth Defect
ARO1 YDR127W Pentafunctional arom protein genetic 1 1 1 Negative Genetic
BET3 YKR068C Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Positive Genetic
BET2 YPR176C Beta subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
CCL1 YPR025C Cyclin partner of the cyclin-dependent kinase (CDK) Kin28p genetic 1 1 1 Dosage Growth Defect
BOI2 YER114C Protein involved in polar growth physical 1 1 1 Two-hybrid
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 Affinity Capture-Western
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Negative Genetic
CDC10 YCR002C Component of the septin ring, required for cytokinesis physical 1 1 1 Biochemical Activity
CDC11 YJR076C Component of the septin ring that is required for cytokinesis physical 1 1 1 Biochemical Activity
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 1 1 1 Negative Genetic
CEG1 YGL130W Guanylyltransferase involved in mRNA 5' capping genetic 1 1 1 Negative Genetic
CIA2 YHR122W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Positive Genetic
BDF2 YDL070W Protein involved in transcription initiation physical 1 1 1 Biochemical Activity
BLM10 YFL007W Proteasome activator genetic 1 1 1 Negative Genetic
ATG9 YDL149W Transmembrane protein involved in forming Cvt and autophagic vesicles physical 1 1 1 Biochemical Activity
BET5 YML077W Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Positive Genetic
ABP1 YCR088W Actin-binding protein of the cortical actin cytoskeleton physical 1 1 1 Two-hybrid
ACO1 YLR304C Aconitase genetic 1 1 1 Dosage Growth Defect
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
CDC53 YDL132W Cullin genetic 1 1 1 Negative Genetic
BFA1 YJR053W Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p genetic 1 1 1 Synthetic Rescue
CAF120 YNL278W Part of the CCR4-NOT transcriptional regulatory complex genetic 1 1 1 Dosage Growth Defect
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 1 1 1 Negative Genetic
AFR1 YDR085C Protein required for pheromone-induced projection (shmoo) formation genetic 1 1 1 Dosage Growth Defect
BEM3 YPL115C Rho GTPase activating protein (RhoGAP) physical 1 1 1 Two-hybrid
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network physical 1 1 1 Biochemical Activity
CDC123 YLR215C Assembly factor for the eIF2 translation initiation factor complex genetic 1 1 1 Negative Genetic
CAF4 YKR036C WD40 repeat-containing protein associated with the CCR4-NOT complex genetic 1 1 1 Dosage Growth Defect
BUD7 YOR299W Member of the ChAPs family (Chs5p-Arf1p-binding proteins) genetic 1 1 1 Negative Genetic
CIK1 YMR198W Kinesin-associated protein genetic 1 1 1 Negative Genetic
CBR1 YIL043C Cytochrome b reductase and NADH-dependent reductase for Dph3p genetic 1 1 1 Synthetic Lethality
ARP1 YHR129C Actin-related protein of the dynactin complex genetic 1 1 1 Synthetic Lethality
CDC43 YGL155W Beta subunit of geranylgeranyltransferase type I genetic 1 1 1 Negative Genetic
BNI4 YNL233W Targeting subunit for Glc7p protein phosphatase genetic 1 1 1 Negative Genetic
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis genetic 1 1 1 Negative Genetic
ALY2 YJL084C Alpha arrestin, Ub-ligase adaptor for Rsp5p physical 1 1 1 Biochemical Activity
CDC27 YBL084C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
CEP3 YMR168C Essential kinetochore protein genetic 1 1 1 Positive Genetic
BRN1 YBL097W Subunit of the condensin complex genetic 1 1 1 Positive Genetic
BNI5 YNL166C Linker protein responsible for recruitment of myosin to the bud neck genetic 1 1 1 Dosage Growth Defect
BIK1 YCL029C Microtubule-associated protein genetic 1 1 1 Dosage Growth Defect
CCS1 YMR038C Copper chaperone for superoxide dismutase Sod1p genetic 1 1 1 Synthetic Growth Defect
CDC19 YAL038W Pyruvate kinase genetic 1 1 1 Dosage Growth Defect
ADY4 YLR227C Structural component of the meiotic outer plaque genetic 1 1 1 Dosage Growth Defect
GIC1 YHR061C Rho-family GTPase interacting protein and Cdc42p effector physical 1 1 1 Two-hybrid
GIC2 YDR309C Rho-family GTPase interacting protein and Cdc42p effector physical 1 1 1 Two-hybrid
MSB2 YGR014W Mucin family member involved in various signaling pathways physical 1 1 1 Two-hybrid
RGA1 YOR127W GTPase-activating protein for polarity-regulator Cdc42p (RhoGAP) physical 1 1 1 Two-hybrid
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis physical 1 1 1 Two-hybrid
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Dosage Growth Defect
ZDS2 YML109W Protein with a role in regulating Swe1p-dependent polarized growth physical 1 1 1 Two-hybrid
STE11 YLR362W Signal transducing MEK kinase physical 1 1 1 Biochemical Activity
STE11 YLR362W Signal transducing MEK kinase genetic 1 1 1 Phenotypic Suppression
MYO3 YKL129C One of two type I myosins physical 1 1 1 Biochemical Activity
MYO3 YKL129C One of two type I myosins genetic 1 1 1 Phenotypic Enhancement
SWE1 YJL187C Protein kinase that regulates the G2/M transition physical 1 1 1 Biochemical Activity
PBP1 YGR178C Component of glucose deprivation induced stress granules physical 1 1 1 Affinity Capture-MS
PRE8 YML092C Alpha 2 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
RPL36A YMR194W Ribosomal 60S subunit protein L36A physical 1 1 1 Affinity Capture-MS
RPL36B YPL249C-A Ribosomal 60S subunit protein L36B physical 1 1 1 Affinity Capture-MS
RPL7A YGL076C Ribosomal 60S subunit protein L7A physical 1 1 1 Affinity Capture-MS
RPL7B YPL198W Ribosomal 60S subunit protein L7B physical 1 1 1 Affinity Capture-MS
RPP2A YOL039W Ribosomal protein P2 alpha physical 1 1 1 Affinity Capture-MS
RPS2 YGL123W Protein component of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
SEC23 YPR181C GTPase-activating protein, stimulates the GTPase activity of Sar1p physical 1 1 1 Affinity Capture-MS
SKM1 YOL113W Member of the PAK family of serine/threonine protein kinases physical 1 1 1 Affinity Capture-MS
SKM1 YOL113W Member of the PAK family of serine/threonine protein kinases genetic 1 1 1 Synthetic Growth Defect
YBR225W YBR225W Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
YHB1 YGR234W Nitric oxide oxidoreductase physical 1 1 1 Affinity Capture-MS
PTA1 YAL043C Subunit of holo-CPF physical 1 1 1 Biochemical Activity
RGC1 YPR115W Putative regulator of the Fps1p glycerol channel physical 1 1 1 Biochemical Activity
RTT102 YGR275W Component of both the SWI/SNF and RSC chromatin remodeling complexes physical 1 1 1 Biochemical Activity
GFA1 YKL104C Glutamine-fructose-6-phosphate amidotransferase physical 1 1 1 Biochemical Activity
UTP11 YKL099C Subunit of U3-containing Small Subunit (SSU) processome complex physical 1 1 1 Biochemical Activity
RNH70 YGR276C 3'-5' exoribonuclease physical 1 1 1 Biochemical Activity
YBR298C-A YBR298C-A Putative protein of unknown function physical 1 1 1 Biochemical Activity
GVP36 YIL041W BAR domain protein that localizes to early and late Golgi vesicles physical 1 1 1 Biochemical Activity
TRM7 YBR061C 2'-O-ribose methyltransferase physical 1 1 1 Biochemical Activity
TRM7 YBR061C 2'-O-ribose methyltransferase genetic 1 1 1 Dosage Growth Defect
RSC30 YHR056C Component of the RSC chromatin remodeling complex physical 1 1 1 Biochemical Activity
FRT2 YAL028W Tail-anchored ER membrane protein of unknown function physical 1 1 1 Biochemical Activity
FRT2 YAL028W Tail-anchored ER membrane protein of unknown function genetic 1 1 1 Dosage Growth Defect
SAS10 YDL153C Subunit of U3-containing Small Subunit (SSU) processome complex physical 1 1 1 Biochemical Activity
ISA2 YPR067W Protein required for maturation of mitochondrial [4Fe-4S] proteins physical 1 1 1 Biochemical Activity
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
WHI3 YNL197C RNA binding protein that modulates mRNA stability physical 1 1 1 Protein-RNA
SUT1 YGL162W Zn(II)2Cys6 family transcription factor physical 1 1 1 Affinity Capture-Western
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase physical 1 1 1 Affinity Capture-MS
GBP2 YCL011C Poly(A+) RNA-binding protein physical 1 1 1 Affinity Capture-MS
GSC2 YGR032W Catalytic subunit of 1,3-beta-glucan synthase physical 1 1 1 Affinity Capture-MS
GSC2 YGR032W Catalytic subunit of 1,3-beta-glucan synthase genetic 1 1 1 Dosage Growth Defect
HRB1 YNL004W Poly(A+) RNA-binding protein physical 1 1 1 Affinity Capture-MS
RIM1 YCR028C-A ssDNA-binding protein essential for mitochondrial genome maintenance physical 1 1 1 Affinity Capture-MS
DUT1 YBR252W Deoxyuridine triphosphate diphosphatase (dUTPase) physical 1 1 1 Reconstituted Complex
EAF6 YJR082C Subunit of the NuA4 acetyltransferase complex physical 1 1 1 Reconstituted Complex
ELP2 YGR200C Subunit of Elongator complex physical 1 1 1 Reconstituted Complex
RPL4A YBR031W Ribosomal 60S subunit protein L4A physical 1 1 1 Reconstituted Complex
YJL070C YJL070C Putative metallo-dependent hydrolase superfamily protein physical 1 1 1 Reconstituted Complex
YJL070C YJL070C Putative metallo-dependent hydrolase superfamily protein genetic 1 1 1 Dosage Growth Defect
SKA1 YKL023W SKI complex-associated protein physical 1 1 1 Reconstituted Complex
SPT7 YBR081C Subunit of the SAGA transcriptional regulatory complex physical 1 1 1 Affinity Capture-MS
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes physical 1 1 1 Affinity Capture-MS
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Negative Genetic
HHF2 YNL030W Histone H4 physical 1 1 1 Affinity Capture-MS
HHF2 YNL030W Histone H4 genetic 1 1 1 Positive Genetic
HHT1 YBR010W Histone H3 physical 1 1 1 Affinity Capture-MS
HHT2 YNL031C Histone H3 physical 1 1 1 Affinity Capture-MS
FUS2 YMR232W Cell fusion regulator physical 1 1 1 Biochemical Activity
COG4 YPR105C Essential component of the conserved oligomeric Golgi complex physical 1 1 1 Biochemical Activity
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Biochemical Activity
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
RSC8 YFR037C Component of the RSC chromatin remodeling complex physical 1 1 1 Biochemical Activity
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase physical 1 1 1 Biochemical Activity
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Negative Genetic
SPB1 YCL054W AdoMet-dependent methyltransferase physical 1 1 1 Biochemical Activity
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 1 1 1 Biochemical Activity
UTP5 YDR398W Subunit of U3-containing Small Subunit (SSU) processome complex physical 1 1 1 Biochemical Activity
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-Western
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
RPB3 YIL021W RNA polymerase II third largest subunit B44 physical 1 1 1 Affinity Capture-MS
RPB3 YIL021W RNA polymerase II third largest subunit B44 genetic 1 1 1 Negative Genetic
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
UBP15 YMR304W Ubiquitin-specific protease involved in protein deubiquitination physical 1 1 1 Affinity Capture-MS
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RRP43 YCR035C Exosome non-catalytic core component physical 1 1 1 Affinity Capture-MS
RPL17A YKL180W Ribosomal 60S subunit protein L17A genetic 1 1 1 Synthetic Lethality
RPS21A YKR057W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Lethality
RAD10 YML095C Single-stranded DNA endonuclease (with Rad1p) genetic 1 1 1 Synthetic Lethality
SIT4 YDL047W Ceramide-activated, type 2A-related serine-threonine phosphatase genetic 1 1 1 Synthetic Lethality
TPM2 YIL138C Minor isoform of tropomyosin genetic 1 1 1 Phenotypic Enhancement
MYO5 YMR109W One of two type I myosin motors genetic 1 1 1 Phenotypic Enhancement
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Synthetic Lethality
KAR9 YPL269W Spindle positioning factor genetic 1 1 1 Synthetic Growth Defect
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 1 1 1 Synthetic Growth Defect
TAF14 YPL129W Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes genetic 1 1 1 Negative Genetic
THP1 YOL072W Nuclear pore-associated protein genetic 1 1 1 Negative Genetic
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 1 1 1 Negative Genetic
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes genetic 1 1 1 Negative Genetic
RXT3 YDL076C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 1 1 1 Negative Genetic
SWD2 YKL018W Subunit of the COMPASS (Set1C) histone H3K4 methyltransferase complex genetic 1 1 1 Negative Genetic
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 1 1 1 Phenotypic Suppression
SPT4 YGR063C Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 1 1 1 Negative Genetic
IES1 YFL013C Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
RSC58 YLR033W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
MSH1 YHR120W DNA-binding protein of the mitochondria genetic 1 1 1 Negative Genetic
NTO1 YPR031W Subunit of the NuA3 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
PDR1 YGL013C Transcription factor that regulates the pleiotropic drug response genetic 1 1 1 Phenotypic Enhancement
ERG4 YGL012W C-24(28) sterol reductase genetic 1 1 1 Synthetic Lethality
NCP1 YHR042W NADP-cytochrome P450 reductase genetic 1 1 1 Synthetic Lethality
OCH1 YGL038C Mannosyltransferase of the cis-Golgi apparatus genetic 1 1 1 Synthetic Lethality
JNM1 YMR294W Component of the yeast dynactin complex genetic 1 1 1 Synthetic Lethality
HCM1 YCR065W Forkhead transcription factor genetic 1 1 1 Positive Genetic
HXK2 YGL253W Hexokinase isoenzyme 2 genetic 1 1 1 Positive Genetic
OCA5 YHL029C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Positive Genetic
THR1 YHR025W Homoserine kinase genetic 1 1 1 Positive Genetic
LRP1 YHR081W Nuclear exosome-associated nucleic acid binding protein genetic 1 1 1 Positive Genetic
PPX1 YHR201C Exopolyphosphatase genetic 1 1 1 Negative Genetic
PKP1 YIL042C Mitochondrial protein kinase genetic 1 1 1 Negative Genetic
IME1 YJR094C Master regulator of meiosis that is active only during meiotic events genetic 1 1 1 Negative Genetic
FAR10 YLR238W Protein involved in recovery from arrest in response to pheromone genetic 1 1 1 Positive Genetic
TEP1 YNL128W PTEN homolog with no demonstrated inositol lipid phosphatase activity genetic 1 1 1 Negative Genetic
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Positive Genetic
GCN2 YDR283C Protein kinase genetic 1 1 1 Positive Genetic
HAL5 YJL165C Snf1p-related nutrient-responsive protein kinase genetic 1 1 1 Negative Genetic
TPK3 YKL166C cAMP-dependent protein kinase catalytic subunit genetic 1 1 1 Positive Genetic
IRS4 YKR019C EH domain-containing protein genetic 1 1 1 Positive Genetic
NRM1 YNR009W Transcriptional co-repressor of MBF-regulated gene expression genetic 1 1 1 Negative Genetic
PPG1 YNR032W Serine protein phosphatase involved in formation of FAR complex genetic 1 1 1 Positive Genetic
PSK2 YOL045W PAS-domain containing serine/threonine protein kinase genetic 1 1 1 Negative Genetic
SKI7 YOR076C GTP-binding protein that couples the Ski complex and exosome genetic 1 1 1 Positive Genetic
HEM1 YDR232W 5-aminolevulinate synthase genetic 1 1 1 Phenotypic Suppression
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation genetic 1 1 1 Synthetic Growth Defect
HTA1 YDR225W Histone H2A genetic 1 1 1 Negative Genetic
HTB1 YDR224C Histone H2B genetic 1 1 1 Negative Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 1 1 1 Synthetic Growth Defect
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Synthetic Growth Defect
DDC1 YPL194W DNA damage checkpoint protein genetic 1 1 1 Synthetic Growth Defect
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 1 1 1 Synthetic Growth Defect
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 1 1 1 Synthetic Growth Defect
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 1 1 1 Synthetic Growth Defect
HST1 YOL068C NAD(+)-dependent histone deacetylase genetic 1 1 1 Synthetic Growth Defect
NPT1 YOR209C Nicotinate phosphoribosyltransferase genetic 1 1 1 Synthetic Growth Defect
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 1 1 1 Synthetic Growth Defect
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Synthetic Growth Defect
NAT1 YDL040C Subunit of protein N-terminal acetyltransferase NatA genetic 1 1 1 Synthetic Growth Defect
POL32 YJR043C Third subunit of DNA polymerase delta genetic 1 1 1 Synthetic Growth Defect
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 1 1 1 Synthetic Growth Defect
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Growth Defect
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 1 1 1 Synthetic Growth Defect
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 1 1 1 Synthetic Growth Defect
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Synthetic Growth Defect
VOA1 YGR106C ER protein that functions in assembly of the V0 sector of V-ATPase genetic 1 1 1 Synthetic Growth Defect
YPT31 YER031C Rab family GTPase genetic 1 1 1 Negative Genetic
TAT1 YBR069C Amino acid transporter for valine, leucine, isoleucine, and tyrosine genetic 1 1 1 Negative Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Negative Genetic
PER1 YCR044C Protein of the endoplasmic reticulum genetic 1 1 1 Negative Genetic
PEP5 YMR231W Histone E3 ligase, component of CORVET membrane tethering complex genetic 1 1 1 Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Positive Genetic
OCA6 YDR067C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Positive Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Negative Genetic
ELP3 YPL086C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 1 1 1 Negative Genetic
UME1 YPL139C Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Negative Genetic
DAT1 YML113W DNA binding protein that recognizes oligo(dA).oligo(dT) tracts genetic 1 1 1 Negative Genetic
IES3 YLR052W Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 1 1 1 Negative Genetic
FPK1 YNR047W Ser/Thr protein kinase genetic 1 1 1 Negative Genetic
TYE7 YOR344C Serine-rich protein that contains a bHLH DNA binding motif genetic 1 1 1 Negative Genetic
MBP1 YDL056W Transcription factor genetic 1 1 1 Negative Genetic
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
ROX1 YPR065W Heme-dependent repressor of hypoxic genes genetic 1 1 1 Positive Genetic
KIN1 YDR122W S/T protein kinase genetic 1 1 1 Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Negative Genetic
SKO1 YNL167C Basic leucine zipper transcription factor of the ATF/CREB family genetic 1 1 1 Negative Genetic
SPT23 YKL020C ER membrane protein involved in regulation of OLE1 transcription genetic 1 1 1 Negative Genetic
SNF7 YLR025W One of four subunits of the ESCRT-III complex genetic 1 1 1 Synthetic Growth Defect
MED8 YBR193C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
ILM1 YJR118C Protein of unknown function genetic 1 1 1 Negative Genetic
PGA3 YML125C Putative cytochrome b5 reductase, localized to the plasma membrane genetic 1 1 1 Negative Genetic
HOF1 YMR032W F-BAR protein that regulates actin cytoskeleton organization genetic 1 1 1 Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Negative Genetic
PFA4 YOL003C Palmitoyltransferase with autoacylation activity genetic 1 1 1 Negative Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Negative Genetic
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 1 1 1 Synthetic Growth Defect
LST8 YNL006W Protein required for the transport of Gap1p genetic 1 1 1 Negative Genetic
LCB3 YJL134W Long-chain base-1-phosphate phosphatase genetic 1 1 1 Negative Genetic
SWA2 YDR320C Auxilin-like protein involved in vesicular transport genetic 1 1 1 Negative Genetic
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) genetic 1 1 1 Negative Genetic
TDH3 YGR192C Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 3 genetic 1 1 1 Negative Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family genetic 1 1 1 Negative Genetic
SPF1 YEL031W P-type ATPase, ion transporter of the ER membrane genetic 1 1 1 Negative Genetic
GPI17 YDR434W Transmembrane protein genetic 1 1 1 Negative Genetic
ERD1 YDR414C Predicted membrane protein required for lumenal ER protein retention genetic 1 1 1 Positive Genetic
LAS21 YJL062W Mannose-ethanolamine phosphotransferase genetic 1 1 1 Negative Genetic
ECM33 YBR078W GPI-anchored protein involved in efficient glucose uptake genetic 1 1 1 Negative Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Negative Genetic
VPS21 YOR089C Endosomal Rab family GTPase genetic 1 1 1 Negative Genetic
ERG26 YGL001C C-3 sterol dehydrogenase genetic 1 1 1 Negative Genetic
SEC1 YDR164C Sm-like protein involved in docking and fusion of exocytic vesicles genetic 1 1 1 Negative Genetic
RPN3 YER021W Essential non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Negative Genetic
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
PRE3 YJL001W Beta 1 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
OSH3 YHR073W Member of an oxysterol-binding protein family genetic 1 1 1 Negative Genetic
SKG3 YLR187W Protein of unknown function genetic 1 1 1 Dosage Growth Defect
YER085C YER085C Putative protein of unknown function genetic 1 1 1 Dosage Growth Defect
PRM2 YIL037C Pheromone-regulated protein genetic 1 1 1 Dosage Growth Defect
KEL2 YGR238C Protein that negatively regulates mitotic exit genetic 1 1 1 Dosage Growth Defect
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 1 1 1 Dosage Growth Defect
PRR1 YKL116C Serine/threonine protein kinase genetic 1 1 1 Dosage Growth Defect
PHO80 YOL001W Cyclin genetic 1 1 1 Dosage Growth Defect
YIR016W YIR016W Putative protein of unknown function genetic 1 1 1 Dosage Growth Defect
YPK1 YKL126W S/T protein kinase genetic 1 1 1 Dosage Growth Defect
PXP2 YJR111C Peroxisomal matrix protein with naturally active promoter genetic 1 1 1 Dosage Growth Defect
PCL6 YER059W Pho85p cyclin of the Pho80p subfamily genetic 1 1 1 Dosage Growth Defect
SCW4 YGR279C Cell wall protein with similarity to glucanases genetic 1 1 1 Dosage Growth Defect
NNK1 YKL171W Protein kinase genetic 1 1 1 Dosage Growth Defect
YMR295C YMR295C Protein of unknown function that associates with ribosomes genetic 1 1 1 Dosage Growth Defect
YCK1 YHR135C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform genetic 1 1 1 Dosage Growth Defect
PHR1 YOR386W DNA photolyase involved in photoreactivation genetic 1 1 1 Dosage Growth Defect
YER137C-A YER137C-A Retrotransposon TYA Gag gene co-transcribed with TYB Pol genetic 1 1 1 Dosage Growth Defect
YPL199C YPL199C Protein involved in nonstop mRNA decay genetic 1 1 1 Dosage Growth Defect
YDL186W YDL186W Putative protein of unknown function genetic 1 1 1 Dosage Growth Defect
LEE1 YPL054W Zinc-finger protein of unknown function genetic 1 1 1 Dosage Growth Defect
MSB3 YNL293W Rab GTPase-activating protein genetic 1 1 1 Dosage Growth Defect
SVF1 YDR346C Protein with a potential role in cell survival pathways genetic 1 1 1 Dosage Growth Defect
RTR1 YER139C Dual specificity protein phosphatase genetic 1 1 1 Dosage Growth Defect
NIT3 YLR351C Nit protein genetic 1 1 1 Dosage Growth Defect
CNM67 YNL225C Component of the spindle pole body outer plaque genetic 1 1 1 Dosage Growth Defect
MRX16 YDR132C Protein that associates with the large mitoribosomal subunit genetic 1 1 1 Dosage Growth Defect
MAD2 YJL030W Component of the spindle-assembly checkpoint complex genetic 1 1 1 Dosage Growth Defect
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 1 1 1 Dosage Growth Defect
CSA1 YPR174C Protein of unknown function genetic 1 1 1 Dosage Growth Defect
ENV7 YPL236C Vacuolar membrane protein kinase genetic 1 1 1 Dosage Growth Defect
WHI4 YDL224C Putative RNA binding protein genetic 1 1 1 Dosage Growth Defect
DON1 YDR273W Meiosis-specific component of the spindle pole body genetic 1 1 1 Dosage Growth Defect
RRP7 YCL031C Essential protein involved in rRNA processing and ribosome biogenesis genetic 1 1 1 Dosage Growth Defect
MSH6 YDR097C Protein required for mismatch repair in mitosis and meiosis genetic 1 1 1 Dosage Growth Defect
SAP1 YER047C Putative ATPase of the AAA family genetic 1 1 1 Dosage Growth Defect
DSE3 YOR264W Daughter cell-specific protein, may help establish daughter fate genetic 1 1 1 Dosage Growth Defect
YPR015C YPR015C Putative zinc finger transcription factor genetic 1 1 1 Dosage Growth Defect
KCH1 YJR054W Potassium transporter that mediates K+ influx genetic 1 1 1 Dosage Growth Defect
FUS1 YCL027W Membrane protein localized to the shmoo tip genetic 1 1 1 Dosage Growth Defect
IRC6 YFR043C Clathrin coat accessory factor genetic 1 1 1 Dosage Growth Defect
TOS7 YOL019W Protein involved in secretion and cell wall organization genetic 1 1 1 Dosage Growth Defect
UMP1 YBR173C Chaperone required for correct maturation of the 20S proteasome genetic 1 1 1 Dosage Growth Defect
MCM1 YMR043W Transcription factor genetic 1 1 1 Dosage Growth Defect
YEL1 YBL060W Guanine nucleotide exchange factor specific for Arf3p genetic 1 1 1 Dosage Growth Defect
IRC8 YJL051W Bud tip localized protein of unknown function genetic 1 1 1 Dosage Growth Defect
NCE102 YPR149W Protein of unknown function genetic 1 1 1 Dosage Growth Defect
SDP1 YIL113W Stress-inducible dual-specificity MAP kinase phosphatase genetic 1 1 1 Dosage Growth Defect
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex genetic 1 1 1 Dosage Growth Defect
UBP14 YBR058C Ubiquitin-specific protease genetic 1 1 1 Dosage Growth Defect
YDR261W-A YDR261W-A Retrotransposon TYA Gag gene co-transcribed with TYB Pol genetic 1 1 1 Dosage Growth Defect
GPI16 YHR188C Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Dosage Growth Defect
STO1 YMR125W Large subunit of the nuclear mRNA cap-binding protein complex genetic 1 1 1 Dosage Growth Defect
CRZ1 YNL027W Transcription factor, activates transcription of stress response genes genetic 1 1 1 Dosage Growth Defect
NET1 YJL076W Core subunit of the RENT complex genetic 1 1 1 Dosage Growth Defect
KAP95 YLR347C Karyopherin beta genetic 1 1 1 Dosage Growth Defect
NRG1 YDR043C Transcriptional repressor genetic 1 1 1 Dosage Growth Defect
PAH1 YMR165C Mg2+-dependent phosphatidate (PA) phosphatase genetic 1 1 1 Dosage Growth Defect
OPY1 YBR129C Protein of unknown function genetic 1 1 1 Dosage Growth Defect
KXD1 YGL079W Subunit of the BLOC-1 complex involved in endosomal maturation genetic 1 1 1 Dosage Growth Defect
NTR2 YKR022C Essential protein that forms a dimer with Ntr1p genetic 1 1 1 Dosage Growth Defect
CLB4 YLR210W B-type cyclin involved in cell cycle progression genetic 1 1 1 Dosage Growth Defect
RAS1 YOR101W GTPase involved in G-protein signaling in adenylate cyclase activation genetic 1 1 1 Dosage Growth Defect
DGR2 YKL121W Protein of unknown function genetic 1 1 1 Dosage Growth Defect
MSB1 YOR188W Protein of unknown function genetic 1 1 1 Dosage Growth Defect
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Dosage Growth Defect
GAC1 YOR178C Regulatory subunit for Glc7p type-1 protein phosphatase (PP1) genetic 1 1 1 Dosage Growth Defect
ERG11 YHR007C Lanosterol 14-alpha-demethylase genetic 1 1 1 Dosage Growth Defect
PRM6 YML047C Potassium transporter that mediates K+ influx genetic 1 1 1 Dosage Growth Defect
SSO1 YPL232W Plasma membrane t-SNARE genetic 1 1 1 Dosage Growth Defect
LAA2 YBL010C Clathrin adaptor (adaptin) accessory protein genetic 1 1 1 Dosage Growth Defect
RED1 YLR263W Protein component of the synaptonemal complex axial elements genetic 1 1 1 Dosage Growth Defect
STR2 YJR130C Cystathionine gamma-synthase, converts cysteine into cystathionine genetic 1 1 1 Dosage Growth Defect
YHP1 YDR451C Homeobox transcriptional repressor genetic 1 1 1 Dosage Growth Defect
YGL242C YGL242C Protein of unknown function genetic 1 1 1 Dosage Growth Defect
RPN2 YIL075C Subunit of the 26S proteasome genetic 1 1 1 Dosage Growth Defect
CYC3 YAL039C Cytochrome c heme lyase (holocytochrome c synthase) genetic 1 1 1 Dosage Growth Defect
YJR084W YJR084W Protein that forms a complex with Thp3p genetic 1 1 1 Dosage Growth Defect
PRP38 YGR075C Unique component of the U4/U6.U5 tri-snRNP particle genetic 1 1 1 Dosage Growth Defect
SPS22 YCL048W Protein of unknown function genetic 1 1 1 Dosage Growth Defect
YLR410W-B YLR410W-B Retrotransposon TYA Gag and TYB Pol genes genetic 1 1 1 Dosage Growth Defect
UBX3 YDL091C Clathrin-coated vesicle component, regulator of endocytosis genetic 1 1 1 Dosage Growth Defect
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 1 1 1 Dosage Growth Defect
UBP6 YFR010W Ubiquitin-specific protease genetic 1 1 1 Dosage Growth Defect
TAT2 YOL020W High affinity tryptophan and tyrosine permease genetic 1 1 1 Dosage Growth Defect
YOL029C YOL029C Putative protein of unknown function genetic 1 1 1 Dosage Growth Defect
PIG1 YLR273C Putative targeting subunit for type-1 protein phosphatase Glc7p genetic 1 1 1 Dosage Growth Defect
YPL229W YPL229W Putative protein of unknown function genetic 1 1 1 Dosage Growth Defect
PHD1 YKL043W Transcriptional activator that enhances pseudohyphal growth genetic 1 1 1 Dosage Growth Defect
GLG1 YKR058W Glycogenin glucosyltransferase genetic 1 1 1 Dosage Growth Defect
DOT5 YIL010W Nuclear thiol peroxidase genetic 1 1 1 Dosage Growth Defect
LAS17 YOR181W Actin assembly factor genetic 1 1 1 Dosage Growth Defect
PPQ1 YPL179W Protein phosphatase that regulates the mating response genetic 1 1 1 Dosage Growth Defect
SNA2 YDR525W-A Protein of unknown function genetic 1 1 1 Dosage Growth Defect
PSH1 YOL054W E3 ubiquitin ligase targeting centromere-binding protein Cse4p genetic 1 1 1 Dosage Growth Defect
TRM44 YPL030W tRNA(Ser) Um(44) 2'-O-methyltransferase genetic 1 1 1 Dosage Growth Defect
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 1 1 1 Dosage Growth Defect
MSS51 YLR203C Specific translational activator for the mitochondrial COX1 mRNA genetic 1 1 1 Dosage Growth Defect
HMT1 YBR034C Nuclear SAM-dependent mono- and asymmetric methyltransferase genetic 1 1 1 Dosage Growth Defect
JJJ2 YJL162C Protein of unknown function genetic 1 1 1 Dosage Growth Defect
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 1 1 1 Dosage Growth Defect
YNL058C YNL058C Putative protein of unknown function genetic 1 1 1 Dosage Growth Defect
RSC4 YKR008W Component of the RSC chromatin remodeling complex genetic 1 1 1 Dosage Growth Defect
RRP5 YMR229C RNA binding protein involved in synthesis of 18S and 5.8S rRNAs genetic 1 1 1 Dosage Growth Defect
MSA1 YOR066W Activator of G1-specific transcription factors MBF and SBF genetic 1 1 1 Dosage Growth Defect
MTR10 YOR160W Nuclear import receptor genetic 1 1 1 Dosage Growth Defect
KEL1 YHR158C Protein required for proper cell fusion and cell morphology genetic 1 1 1 Dosage Growth Defect
SSL2 YIL143C Component of RNA polymerase transcription factor TFIIH holoenzyme genetic 1 1 1 Dosage Growth Defect
YDL129W YDL129W Protein of unknown function genetic 1 1 1 Dosage Growth Defect
RDI1 YDL135C Rho GDP dissociation inhibitor genetic 1 1 1 Dosage Growth Defect
MKK1 YOR231W MAPKK involved in the protein kinase C signaling pathway genetic 1 1 1 Dosage Growth Defect
DSK2 YMR276W Nuclear-enriched ubiquitin-like polyubiquitin-binding protein genetic 1 1 1 Dosage Growth Defect
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Dosage Growth Defect
PAR32 YDL173W Low complexity protein genetic 1 1 1 Dosage Growth Defect
MNR2 YKL064W Vacuolar membrane protein required for magnesium homeostasis genetic 1 1 1 Dosage Growth Defect
MCM6 YGL201C Protein involved in DNA replication genetic 1 1 1 Dosage Growth Defect
UBP7 YIL156W Ubiquitin-specific protease that cleaves ubiquitin-protein fusions genetic 1 1 1 Dosage Growth Defect
RGD3 YHR182W GTPase activating protein (GAP) for Rho3p, involved in cell polarity g genetic 1 1 1 Dosage Growth Defect
ZRG8 YER033C Protein of unknown function genetic 1 1 1 Dosage Growth Defect
YAP1801 YHR161C Protein of the AP180 family, involved in clathrin cage assembly genetic 1 1 1 Dosage Growth Defect
DOA4 YDR069C Ubiquitin hydrolase genetic 1 1 1 Dosage Growth Defect
IRC21 YMR073C Protein of unknown function genetic 1 1 1 Dosage Growth Defect
MSN2 YMR037C Stress-responsive transcriptional activator genetic 1 1 1 Dosage Growth Defect
RSA4 YCR072C Ribosomal large subunit (60S) assembly factor genetic 1 1 1 Dosage Growth Defect
SRO9 YCL037C Cytoplasmic RNA-binding protein genetic 1 1 1 Dosage Growth Defect
YCR051W YCR051W Putative protein of unknown function genetic 1 1 1 Dosage Growth Defect
UBX5 YDR330W UBX domain-containing protein that interacts with Cdc48p genetic 1 1 1 Dosage Growth Defect
SHE3 YBR130C Protein adaptor between Myo4p and the She2p-mRNA complex genetic 1 1 1 Dosage Growth Defect
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Dosage Growth Defect
ECM13 YBL043W Non-essential protein of unknown function genetic 1 1 1 Dosage Growth Defect
GLC3 YEL011W Glycogen branching enzyme, involved in glycogen accumulation genetic 1 1 1 Dosage Growth Defect
GIP4 YAL031C Cytoplasmic protein that regulates protein phosphatase 1 Glc7p genetic 1 1 1 Dosage Growth Defect
TCA17 YEL048C Component of transport protein particle (TRAPP) complex II genetic 1 1 1 Dosage Growth Defect
PGD1 YGL025C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Dosage Growth Defect
MUK1 YPL070W Guanine nucleotide exchange factor (GEF) genetic 1 1 1 Dosage Growth Defect
SBE22 YHR103W Protein involved in bud growth genetic 1 1 1 Dosage Growth Defect
SPO23 YBR250W Protein of unknown function genetic 1 1 1 Dosage Growth Defect
COS111 YBR203W Protein required for antifungal drug ciclopirox olamine resistance genetic 1 1 1 Dosage Growth Defect
NDC1 YML031W Subunit of the transmembrane ring of the nuclear pore complex (NPC) genetic 1 1 1 Dosage Growth Defect
PFK27 YOL136C 6-phosphofructo-2-kinase genetic 1 1 1 Dosage Growth Defect
PHO5 YBR093C Repressible acid phosphatase genetic 1 1 1 Dosage Growth Defect
NRP1 YDL167C Putative RNA binding protein of unknown function genetic 1 1 1 Dosage Growth Defect
PBP2 YBR233W RNA binding protein genetic 1 1 1 Dosage Growth Defect
PAP1 YKR002W Poly(A) polymerase genetic 1 1 1 Dosage Growth Defect
FCP1 YMR277W Carboxy-terminal domain (CTD) phosphatase genetic 1 1 1 Dosage Growth Defect
MNT3 YIL014W Alpha-1,3-mannosyltransferase genetic 1 1 1 Dosage Growth Defect
IQG1 YPL242C Actin filament binding protein that enhances actin ring formation genetic 1 1 1 Dosage Growth Defect
MAK10 YEL053C Non-catalytic subunit of the NatC N-terminal acetyltransferase genetic 1 1 1 Dosage Growth Defect
PCL8 YPL219W Cyclin genetic 1 1 1 Dosage Growth Defect
ECM14 YHR132C Conserved fungal protein with similarity to zinc carboxypeptidases genetic 1 1 1 Dosage Growth Defect
MCM3 YEL032W Protein involved in DNA replication genetic 1 1 1 Dosage Growth Defect
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 1 1 1 Phenotypic Enhancement
MAK16 YAL025C Essential nuclear protein genetic 1 1 1 Positive Genetic
ILS1 YBL076C Cytoplasmic isoleucine-tRNA synthetase genetic 1 1 1 Positive Genetic
TRS20 YBR254C Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Positive Genetic
KRR1 YCL059C Nucleolar protein required for rRNA synthesis and ribosomal assembly genetic 1 1 1 Positive Genetic
TRS23 YDR246W Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Positive Genetic
UTP6 YDR449C Nucleolar protein genetic 1 1 1 Positive Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Positive Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Positive Genetic
RNA15 YGL044C Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Positive Genetic
NBP35 YGL091C Essential cytoplasmic iron-sulfur cluster binding protein genetic 1 1 1 Positive Genetic
SPC105 YGL093W Subunit of a kinetochore-microtubule binding complex genetic 1 1 1 Positive Genetic
USE1 YGL098W Essential SNARE protein localized to the ER genetic 1 1 1 Positive Genetic
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer genetic 1 1 1 Positive Genetic
FIP1 YJR093C Subunit of cleavage polyadenylation factor (CPF) genetic 1 1 1 Positive Genetic
SMC4 YLR086W Subunit of the condensin complex genetic 1 1 1 Positive Genetic
EMG1 YLR186W Methyltransferase for rRNA genetic 1 1 1 Positive Genetic
ERG8 YMR220W Phosphomevalonate kinase genetic 1 1 1 Positive Genetic
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Positive Genetic
SEC12 YNR026C Guanine nucleotide exchange factor (GEF) genetic 1 1 1 Positive Genetic
RAT1 YOR048C Nuclear 5' to 3' single-stranded RNA exonuclease genetic 1 1 1 Positive Genetic
ERG10 YPL028W Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) genetic 1 1 1 Positive Genetic
TBF1 YPL128C Telobox-containing general regulatory factor genetic 1 1 1 Positive Genetic
DIM1 YPL266W Essential 18S rRNA dimethylase (dimethyladenosine transferase) genetic 1 1 1 Positive Genetic
SUA7 YPR086W Transcription factor TFIIB genetic 1 1 1 Positive Genetic
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 1 1 1 Positive Genetic
GOS1 YHL031C v-SNARE protein involved in Golgi transport genetic 1 1 1 Positive Genetic
PRE7 YBL041W Beta 6 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
EXO84 YBR102C Exocyst subunit with dual roles in exocytosis and spliceosome assembly genetic 1 1 1 Negative Genetic
CMD1 YBR109C Calmodulin genetic 1 1 1 Negative Genetic
QRI1 YDL103C UDP-N-acetylglucosamine pyrophosphorylase genetic 1 1 1 Negative Genetic
SUP35 YDR172W Translation termination factor eRF3 genetic 1 1 1 Negative Genetic
RPB7 YDR404C RNA polymerase II subunit B16 genetic 1 1 1 Negative Genetic
PUP3 YER094C Beta 3 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
GNA1 YFL017C Glucosamine-6-phosphate acetyltransferase genetic 1 1 1 Negative Genetic
SEC53 YFL045C Phosphomannomutase genetic 1 1 1 Negative Genetic
SCL1 YGL011C Alpha 1 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
TAF6 YGL112C Subunit (60 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
MIF2 YKL089W Centromeric CDEIII region binding protein genetic 1 1 1 Negative Genetic
PRP43 YGL120C RNA helicase in the DEAH-box family genetic 1 1 1 Negative Genetic
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin genetic 1 1 1 Negative Genetic
PRP18 YGR006W Splicing factor and component of snRNP U5 genetic 1 1 1 Negative Genetic
SMD1 YGR074W Core Sm protein Sm D1 genetic 1 1 1 Negative Genetic
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease genetic 1 1 1 Negative Genetic
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
ORC6 YHR118C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
MOB1 YIL106W Component of the mitotic exit network genetic 1 1 1 Negative Genetic
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 1 1 1 Negative Genetic
PRI1 YIR008C Subunit of DNA primase genetic 1 1 1 Negative Genetic
TAH11 YJR046W DNA replication licensing factor genetic 1 1 1 Negative Genetic
MAK11 YKL021C Protein involved in an early step of 60S ribosomal subunit biogenesis genetic 1 1 1 Negative Genetic
YJU2 YKL095W Essential protein required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
ERG27 YLR100W 3-keto sterol reductase genetic 1 1 1 Negative Genetic
PWP1 YLR196W Protein with WD-40 repeats involved in rRNA processing genetic 1 1 1 Negative Genetic
NOP56 YLR197W Essential evolutionarily-conserved nucleolar protein genetic 1 1 1 Negative Genetic
DBP9 YLR276C DEAD-box protein required for 27S rRNA processing genetic 1 1 1 Negative Genetic
ORC1 YML065W Largest subunit of the origin recognition complex genetic 1 1 1 Negative Genetic
ERB1 YMR049C Constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
LCB1 YMR296C Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
NOP2 YNL061W rRNA m5C methyltransferase genetic 1 1 1 Negative Genetic
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity genetic 1 1 1 Negative Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Synthetic Growth Defect
ETR1 YBR026C 2-enoyl thioester reductase genetic 1 1 1 Negative Genetic
PUF6 YDR496C Pumilio-homology domain protein genetic 1 1 1 Negative Genetic
HUR1 YGL168W Protein with a role in DNA repair genetic 1 1 1 Negative Genetic
EMC5 YIL027C Member of conserved ER transmembrane complex genetic 1 1 1 Negative Genetic
TED1 YIL039W GPI-glycan remodelase genetic 1 1 1 Negative Genetic
VHR1 YIL056W Transcriptional activator genetic 1 1 1 Negative Genetic
IRC25 YLR021W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 1 1 1 Negative Genetic
IZH3 YLR023C Membrane protein involved in zinc ion homeostasis genetic 1 1 1 Negative Genetic
ZDS1 YMR273C Protein with a role in regulating Swe1p-dependent polarized growth genetic 1 1 1 Negative Genetic
LIP5 YOR196C Protein involved in biosynthesis of the coenzyme lipoic acid genetic 1 1 1 Negative Genetic
SAK1 YER129W Upstream serine/threonine kinase for the SNF1 complex genetic 1 1 1 Negative Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Negative Genetic
PSR1 YLL010C Plasma membrane-associated protein phosphatase genetic 1 1 1 Negative Genetic
RPS11A YDR025W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
HSP104 YLL026W Disaggregase genetic 1 1 1 Dosage Growth Defect
SYP1 YCR030C Negative regulator of WASP-Arp23 complex genetic 1 1 1 Synthetic Rescue
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase genetic 1 1 1 Synthetic Rescue
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Negative Genetic
MAG1 YER142C 3-methyl-adenine DNA glycosylase genetic 1 1 1 Negative Genetic
SLX4 YLR135W Endonuclease involved in processing DNA genetic 1 1 1 Negative Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Growth Defect
BYE1 YKL005C Negative regulator of transcription elongation genetic 1 1 1 Dosage Growth Defect
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
CHS2 YBR038W Chitin synthase II genetic 1 1 1 Dosage Growth Defect
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 1 1 1 Positive Genetic
BUD16 YEL029C Putative pyridoxal kinase physical 1 1 1 Reconstituted Complex
AIM9 YER080W Protein of unknown function genetic 1 1 1 Dosage Growth Defect
APQ12 YIL040W Nuclear envelope/ER integral membrane protein genetic 1 1 1 Positive Genetic