Standard name Systematic name Name description Description
RAD18 YCR066W E3 ubiquitin ligase E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA
Visualize the interactome of RAD18
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data 206

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
RAD18 8 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) physical 28 7 17 Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Far Western, Far Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Far Western, Reconstituted Complex, Reconstituted Complex, Two-hybrid, Co-purification, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Biochemical Activity, Two-hybrid
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 25 3 25 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Positive Genetic, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Positive Genetic, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Positive Genetic, Synthetic Rescue
RAD52 YML032C Protein involved in homologous recombination genetic 17 7 14 Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Synthetic Lethality, Dosage Rescue
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) physical 14 3 11 Two-hybrid, Biochemical Activity, Two-hybrid, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Reconstituted Complex, Two-hybrid, Biochemical Activity, Biochemical Activity, Two-hybrid
SIZ1 YDR409W SUMO E3 ligase genetic 12 3 11 Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 12 5 10 Synthetic Lethality, Synthetic Rescue, Dosage Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue
RAD51 YER095W Strand exchange protein genetic 10 5 9 Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Positive Genetic, Dosage Rescue
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 9 4 9 Phenotypic Suppression, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 7 4 7 Phenotypic Enhancement, Phenotypic Enhancement, Positive Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic, Dosage Rescue
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 7 3 7 Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Negative Genetic
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway physical 7 4 3 Affinity Capture-Western, Two-hybrid, Two-hybrid, Biochemical Activity, Two-hybrid, Reconstituted Complex, Reconstituted Complex
REV3 YPL167C Catalytic subunit of DNA polymerase zeta genetic 6 3 6 Synthetic Rescue, Phenotypic Suppression, Negative Genetic, Phenotypic Suppression, Negative Genetic, Phenotypic Suppression
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 6 4 5 Phenotypic Enhancement, Phenotypic Enhancement, Positive Genetic, Phenotypic Suppression, Negative Genetic, Positive Genetic
RAD18 YCR066W E3 ubiquitin ligase physical 6 3 5 Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Biochemical Activity, Two-hybrid
TSA1 YML028W Thioredoxin peroxidase genetic 6 3 5 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
RAD17 YOR368W Checkpoint protein genetic 6 3 5 Negative Genetic, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
RAD57 YDR004W Protein that stimulates strand exchange genetic 6 4 4 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Suppression, Negative Genetic
POL32 YJR043C Third subunit of DNA polymerase delta genetic 6 3 4 Synthetic Rescue, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue, Synthetic Growth Defect, Synthetic Growth Defect
RAD5 YLR032W DNA helicase/Ubiquitin ligase physical 6 2 4 Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid
MGS1 YNL218W Protein with DNA-dependent ATPase and ssDNA annealing activities genetic 5 3 5 Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality
RAD10 YML095C Single-stranded DNA endonuclease (with Rad1p) genetic 5 3 5 Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 5 4 4 Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Positive Genetic, Negative Genetic
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 5 3 4 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Positive Genetic
RAD55 YDR076W Protein that stimulates strand exchange genetic 5 3 3 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Positive Genetic
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) physical 5 3 1 Two-hybrid, Two-hybrid, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase genetic 4 4 4 Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 4 2 4 Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic
RAD24 YER173W Checkpoint protein genetic 4 2 4 Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) genetic 4 2 4 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
APN1 YKL114C Major apurinic/apyrimidinic endonuclease genetic 4 2 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 4 2 4 Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 4 3 3 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
MAG1 YER142C 3-methyl-adenine DNA glycosylase genetic 4 3 3 Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Positive Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 4 3 3 Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
CSM3 YMR048W Replication fork associated factor genetic 4 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
MPH1 YIR002C 3'-5' DNA helicase involved in error-free bypass of DNA lesions genetic 3 3 3 Phenotypic Suppression, Synthetic Growth Defect, Positive Genetic
UBC13 YDR092W E2 ubiquitin-conjugating enzyme physical 3 3 3 Affinity Capture-MS, Affinity Capture-Western, Co-localization
RAD2 YGR258C Single-stranded DNA endonuclease genetic 3 3 3 Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect
CHK1 YBR274W Serine/threonine kinase and DNA damage checkpoint effector genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
DDC1 YPL194W DNA damage checkpoint protein genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
SKN7 YHR206W Nuclear response regulator and transcription factor genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 3 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression
MMS4 YBR098W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 3 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 3 1 3 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 3 3 2 Synthetic Growth Defect, Negative Genetic, Positive Genetic
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 3 3 2 Synthetic Growth Defect, Negative Genetic, Positive Genetic
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 3 2 2 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect
ASF1 YJL115W Nucleosome assembly factor genetic 3 1 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
HHT1 YBR010W Histone H3 genetic 3 1 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) physical 3 2 1 Two-hybrid, Two-hybrid, Reconstituted Complex
SMT3 YDR510W Ubiquitin-like protein of the SUMO family physical 3 2 1 Two-hybrid, Two-hybrid, Reconstituted Complex
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 2 2 2 Phenotypic Enhancement, Synthetic Growth Defect
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RNR4 YGR180C Ribonucleotide-diphosphate reductase (RNR) small subunit genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
RAD4 YER162C Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
SLX4 YLR135W Endonuclease involved in processing DNA genetic 2 2 2 Negative Genetic, Phenotypic Suppression
REV1 YOR346W Deoxycytidyl transferase genetic 2 2 2 Phenotypic Suppression, Synthetic Growth Defect
CIK1 YMR198W Kinesin-associated protein genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 2 2 2 Synthetic Rescue, Synthetic Growth Defect
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
PSY3 YLR376C Component of Shu complex (aka PCSS complex) genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
ADH1 YOL086C Alcohol dehydrogenase genetic 2 1 2 Negative Genetic, Negative Genetic
BRE1 YDL074C E3 ubiquitin ligase genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
NPL3 YDR432W RNA-binding protein genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
RAD16 YBR114W Nucleotide excision repair (NER) protein genetic 2 1 2 Negative Genetic, Negative Genetic
MSH4 YFL003C Protein involved in meiotic recombination genetic 2 1 2 Negative Genetic, Negative Genetic
BUB2 YMR055C Mitotic exit network regulator genetic 2 1 2 Negative Genetic, Negative Genetic
QCR2 YPR191W Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) genetic 2 1 2 Negative Genetic, Negative Genetic
SRS2 YJL092W DNA helicase and DNA-dependent ATPase physical 2 1 2 Two-hybrid, Two-hybrid
RAD53 YPL153C DNA damage response kinase genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
YBP1 YBR216C Protein involved in cellular response to oxidative stress genetic 2 1 2 Negative Genetic, Negative Genetic
SDH9 YJL045W Minor succinate dehydrogenase isozyme genetic 2 1 2 Negative Genetic, Negative Genetic
YRA2 YKL214C Member of the REF (RNA and export factor binding proteins) family genetic 2 1 2 Negative Genetic, Negative Genetic
YML096W YML096W Putative protein with similarity to asparagine synthetases genetic 2 1 2 Negative Genetic, Negative Genetic
YML020W YML020W Putative protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
RAD33 YML011C Protein involved in nucleotide excision repair genetic 2 1 2 Negative Genetic, Negative Genetic
RCM1 YNL022C rRNA m5C methyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
RCF2 YNR018W Cytochrome c oxidase subunit genetic 2 1 2 Negative Genetic, Negative Genetic
YGK3 YOL128C Protein kinase related to mammalian GSK-3 glycogen synthase kinases genetic 2 1 2 Negative Genetic, Negative Genetic
ROX1 YPR065W Heme-dependent repressor of hypoxic genes genetic 2 1 2 Negative Genetic, Negative Genetic
YPR078C YPR078C Putative protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
ULS1 YOR191W Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) genetic 2 1 2 Phenotypic Suppression, Phenotypic Suppression
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 2 1 2 Negative Genetic, Negative Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 2 1 2 Negative Genetic, Negative Genetic
KAR3 YPR141C Minus-end-directed microtubule motor genetic 2 1 2 Negative Genetic, Negative Genetic
JNM1 YMR294W Component of the yeast dynactin complex genetic 2 1 2 Negative Genetic, Negative Genetic
GAL10 YBR019C UDP-glucose-4-epimerase genetic 2 1 2 Negative Genetic, Negative Genetic
CYB5 YNL111C Cytochrome b5 genetic 2 1 2 Negative Genetic, Negative Genetic
OGG1 YML060W Nuclear and mitochondrial glycosylase/lyase genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
PTK2 YJR059W Serine/threonine protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
AAD4 YDL243C Putative aryl-alcohol dehydrogenase genetic 2 1 2 Negative Genetic, Negative Genetic
CYT1 YOR065W Cytochrome c1 genetic 2 1 2 Negative Genetic, Negative Genetic
COX12 YLR038C Subunit VIb of cytochrome c oxidase genetic 2 1 2 Negative Genetic, Negative Genetic
PMP3 YDR276C Small plasma membrane protein genetic 2 1 2 Negative Genetic, Negative Genetic
KCH1 YJR054W Potassium transporter that mediates K+ influx genetic 2 1 2 Negative Genetic, Negative Genetic
RAD30 YDR419W DNA polymerase eta physical 2 2 1 Two-hybrid, Protein-peptide
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
ARD1 YHR013C Subunit of protein N-terminal acetyltransferase NatA genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
NAT1 YDL040C Subunit of protein N-terminal acetyltransferase NatA genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
GET1 YGL020C Subunit of the GET complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
GET2 YER083C Subunit of the GET complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
DIA2 YOR080W Origin-binding F-box protein genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CTF4 YPR135W Chromatin-associated protein genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
BIM1 YER016W Microtubule plus end-tracking protein genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CCS1 YMR038C Copper chaperone for superoxide dismutase Sod1p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
NPT1 YOR209C Nicotinate phosphoribosyltransferase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Synthetic Growth Defect
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex genetic 1 1 1 Phenotypic Enhancement
NSE1 YLR007W Component of the SMC5-SMC6 complex genetic 1 1 1 Phenotypic Enhancement
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Synthetic Growth Defect
LSM3 YLR438C-A Lsm (Like Sm) protein physical 1 1 1 Two-hybrid
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
PRE2 YPR103W Beta 5 subunit of the 20S proteasome genetic 1 1 1 Phenotypic Suppression
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
ARC18 YLR370C Subunit of the ARP2/3 complex genetic 1 1 1 Synthetic Growth Defect
ARO1 YDR127W Pentafunctional arom protein genetic 1 1 1 Negative Genetic
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p genetic 1 1 1 Positive Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Synthetic Lethality
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
HHF2 YNL030W Histone H4 genetic 1 1 1 Synthetic Growth Defect
HSM3 YBR272C Evolutionarily conserved 19S regulatory particle assembly-chaperone genetic 1 1 1 Phenotypic Suppression
LSM2 YBL026W Lsm (Like Sm) protein physical 1 1 1 Two-hybrid
LSM7 YNL147W Lsm (Like Sm) protein genetic 1 1 1 Synthetic Growth Defect
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 1 1 1 Synthetic Growth Defect
MRPL1 YDR116C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control genetic 1 1 1 Synthetic Growth Defect
HTZ1 YOL012C Histone variant H2AZ genetic 1 1 1 Synthetic Growth Defect
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Synthetic Growth Defect
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member genetic 1 1 1 Synthetic Growth Defect
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 1 1 1 Phenotypic Suppression
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 1 1 1 Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Synthetic Rescue
INP52 YNL106C Polyphosphatidylinositol phosphatase genetic 1 1 1 Synthetic Growth Defect
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
PYC2 YBR218C Pyruvate carboxylase isoform genetic 1 1 1 Negative Genetic
MMS2 YGL087C Ubiquitin-conjugating enzyme variant genetic 1 1 1 Phenotypic Suppression
PSK2 YOL045W PAS-domain containing serine/threonine protein kinase genetic 1 1 1 Negative Genetic
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Phenotypic Enhancement
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway genetic 1 1 1 Synthetic Rescue
UBI4 YLL039C Ubiquitin physical 1 1 1 Reconstituted Complex
RAD30 YDR419W DNA polymerase eta genetic 1 1 1 Synthetic Growth Defect
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Synthetic Lethality
ULP1 YPL020C Protease that specifically cleaves Smt3p protein conjugates genetic 1 1 1 Synthetic Rescue
RAD3 YER171W 5' to 3' DNA helicase genetic 1 1 1 Phenotypic Enhancement
UBP6 YFR010W Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
SWI3 YJL176C Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
SRO9 YCL037C Cytoplasmic RNA-binding protein genetic 1 1 1 Negative Genetic
THP1 YOL072W Nuclear pore-associated protein genetic 1 1 1 Negative Genetic
VPS64 YDR200C Protein required for cytoplasm to vacuole targeting of proteins genetic 1 1 1 Negative Genetic
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 1 1 1 Negative Genetic
VSB1 YGR125W Vacuolar membrane protein required for uptake and storage of arginine genetic 1 1 1 Negative Genetic
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Positive Genetic
WSS1 YHR134W SUMO-ligase and SUMO-targeted metalloprotease genetic 1 1 1 Synthetic Growth Defect
UBR1 YGR184C E3 ubiquitin ligase (N-recognin) genetic 1 1 1 Synthetic Growth Defect
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Synthetic Lethality
VAC7 YNL054W Integral vacuolar membrane protein genetic 1 1 1 Synthetic Growth Defect
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase genetic 1 1 1 Synthetic Lethality
RAD23 YEL037C Protein with ubiquitin-like N terminus genetic 1 1 1 Synthetic Growth Defect
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 1 1 1 Synthetic Growth Defect
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
SBA1 YKL117W Co-chaperone that binds and regulates Hsp90 family chaperones genetic 1 1 1 Synthetic Lethality
YEN1 YER041W Holliday junction resolvase genetic 1 1 1 Synthetic Growth Defect
SMC6 YLR383W Subunit of the SMC5-SMC6 complex genetic 1 1 1 Synthetic Growth Defect
RNA14 YMR061W Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Synthetic Growth Defect
SAE2 YGL175C Endonuclease required for telomere elongation genetic 1 1 1 Phenotypic Suppression
RMI1 YPL024W Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex genetic 1 1 1 Positive Genetic
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex genetic 1 1 1 Positive Genetic
SLM3 YDL033C tRNA-specific 2-thiouridylase genetic 1 1 1 Negative Genetic
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 1 1 1 Negative Genetic
SNF6 YHL025W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
RPL8B YLL045C Ribosomal 60S subunit protein L8A genetic 1 1 1 Negative Genetic
RPS1B YML063W Ribosomal protein of the small (40S) subunit genetic 1 1 1 Negative Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Negative Genetic
SWS2 YNL081C Putative mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
SUE1 YPR151C Protein required for degradation of unstable forms of cytochrome c genetic 1 1 1 Negative Genetic
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Negative Genetic
RAD59 YDL059C Protein involved DNA double-strand break repair genetic 1 1 1 Negative Genetic
RAD61 YDR014W Subunit of a complex that inhibits sister chromatid cohesion genetic 1 1 1 Negative Genetic
SHU1 YHL006C Component of Shu complex (aka PCSS complex) genetic 1 1 1 Negative Genetic
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 1 1 1 Phenotypic Suppression
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) genetic 1 1 1 Phenotypic Suppression
RTT106 YNL206C Histone chaperone genetic 1 1 1 Phenotypic Suppression
CIN8 YEL061C Bipolar kinesin motor protein genetic 1 1 1 Negative Genetic
NTG1 YAL015C DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase genetic 1 1 1 Synthetic Growth Defect
OMS1 YDR316W Protein integral to the mitochondrial membrane genetic 1 1 1 Negative Genetic
ELC1 YPL046C Elongin C, conserved among eukaryotes genetic 1 1 1 Synthetic Growth Defect
MEC3 YLR288C DNA damage and meiotic pachytene checkpoint protein genetic 1 1 1 Synthetic Growth Defect
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 1 1 1 Synthetic Growth Defect
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Synthetic Growth Defect
PHO86 YJL117W Endoplasmic reticulum (ER) resident protein genetic 1 1 1 Negative Genetic
APM4 YOL062C Cargo-binding mu subunit of AP-2 physical 1 1 1 Two-hybrid
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 1 1 1 Synthetic Lethality
MTQ2 YDR140W S-adenosylmethionine-dependent methyltransferase genetic 1 1 1 Synthetic Growth Defect
ADE2 YOR128C Phosphoribosylaminoimidazole carboxylase physical 1 1 1 Two-hybrid
CHL1 YPL008W Probable DNA helicase genetic 1 1 1 Synthetic Growth Defect
BRE5 YNR051C Ubiquitin protease cofactor genetic 1 1 1 Synthetic Growth Defect
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Negative Genetic
CTK2 YJL006C Beta subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Synthetic Lethality
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 1 1 1 Phenotypic Suppression
RAD17 YOR368W Checkpoint protein physical 1 1 1 Two-hybrid
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
NIP100 YPL174C Large subunit of the dynactin complex genetic 1 1 1 Negative Genetic
HHT2 YNL031C Histone H3 genetic 1 1 1 Synthetic Growth Defect
BCS1 YDR375C Protein translocase and chaperone required for Complex III assembly genetic 1 1 1 Negative Genetic
MON2 YNL297C Protein with a role in endocytosis and vacuole integrity genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Negative Genetic
MTC1 YJL123C Protein of unknown function that may interact with ribosomes genetic 1 1 1 Negative Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 1 1 1 Synthetic Growth Defect
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
NTG2 YOL043C DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase genetic 1 1 1 Synthetic Growth Defect
MDM34 YGL219C Mitochondrial component of the ERMES complex genetic 1 1 1 Synthetic Growth Defect
HER2 YMR293C Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex genetic 1 1 1 Synthetic Growth Defect
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Negative Genetic
DPI34 YOR114W Putative mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
PIF1 YML061C DNA helicase, potent G-quadruplex DNA binder/unwinder genetic 1 1 1 Phenotypic Enhancement
CBT1 YKL208W Protein involved in 5' RNA end processing genetic 1 1 1 Negative Genetic
HMI1 YOL095C Mitochondrial inner membrane localized ATP-dependent DNA helicase genetic 1 1 1 Positive Genetic