Standard name Systematic name Name description Description
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease Subunit of structure-specific Mms4p-Mus81p endonuclease; cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); helix-hairpin-helix protein; phosphorylation of non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates function of Mms4p-Mus81p
Visualize the interactome of MUS81
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data 300

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
MUS81 6 3 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 30 5 24 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Rescue, Synthetic Lethality, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic
YEN1 YER041W Holliday junction resolvase genetic 23 4 16 Synthetic Growth Defect, Dosage Rescue, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Dosage Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Dosage Rescue
MMS4 YBR098W Subunit of structure-specific Mms4p-Mus81p endonuclease physical 18 6 14 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Affinity Capture-MS, Co-purification, Reconstituted Complex, Affinity Capture-Western, Co-crystal Structure, Co-purification, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 13 4 11 Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 13 3 8 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 13 3 7 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
POL32 YJR043C Third subunit of DNA polymerase delta genetic 10 3 7 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Negative Genetic, Negative Genetic, Phenotypic Suppression, Negative Genetic
MPH1 YIR002C 3'-5' DNA helicase involved in error-free bypass of DNA lesions genetic 8 5 6 Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Lethality, Phenotypic Suppression, Negative Genetic, Positive Genetic
RAD52 YML032C Protein involved in homologous recombination genetic 8 5 6 Synthetic Rescue, Synthetic Growth Defect, Synthetic Lethality, Synthetic Rescue, Synthetic Rescue, Positive Genetic, Positive Genetic, Negative Genetic
DIA2 YOR080W Origin-binding F-box protein genetic 8 3 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
RMI1 YPL024W Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex genetic 7 2 7 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic
TSA1 YML028W Thioredoxin peroxidase genetic 7 3 5 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
RAD51 YER095W Strand exchange protein genetic 6 5 6 Synthetic Lethality, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Rescue, Positive Genetic
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 6 3 6 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
TOP3 YLR234W DNA Topoisomerase III genetic 6 2 6 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic
ULS1 YOR191W Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) genetic 6 3 4 Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Enhancement
SMC6 YLR383W Subunit of the SMC5-SMC6 complex genetic 6 2 4 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 5 2 5 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 5 5 4 Synthetic Growth Defect, Synthetic Rescue, Negative Genetic, Positive Genetic, Dosage Lethality
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 5 2 4 Phenotypic Suppression, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 5 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor genetic 5 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
SLX4 YLR135W Endonuclease involved in processing DNA genetic 4 3 3 Phenotypic Suppression, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 4 3 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Positive Genetic
RAD55 YDR076W Protein that stimulates strand exchange genetic 4 3 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Positive Genetic
RNH203 YLR154C Ribonuclease H2 subunit genetic 4 3 2 Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic
CDC5 YMR001C Polo-like kinase required for mitotic exit physical 3 2 3 Affinity Capture-MS, Biochemical Activity, Biochemical Activity
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
TOP1 YOL006C Topoisomerase I genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange physical 3 3 2 Two-hybrid, Affinity Capture-Western, Reconstituted Complex
RAD18 YCR066W E3 ubiquitin ligase genetic 3 3 2 Synthetic Growth Defect, Negative Genetic, Positive Genetic
RAD57 YDR004W Protein that stimulates strand exchange genetic 3 3 2 Synthetic Rescue, Positive Genetic, Negative Genetic
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 3 2 2 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
RNH202 YDR279W Ribonuclease H2 subunit genetic 3 2 2 Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
CDC73 YLR418C Component of the Paf1p complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
NSE5 YML023C Component of the SMC5-SMC6 complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
AZF1 YOR113W Zinc-finger transcription factor genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence
LSM1 YJL124C Lsm (Like Sm) protein genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 2 2 2 Dosage Rescue, Phenotypic Suppression
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
TDP1 YBR223C Tyrosyl-DNA phosphodiesterase I genetic 2 2 2 Phenotypic Enhancement, Synthetic Lethality
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
RSC6 YCR052W Component of the RSC chromatin remodeling complex genetic 2 2 2 Positive Genetic, Negative Genetic
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
MMS4 YBR098W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 2 2 2 Positive Genetic, Negative Genetic
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) genetic 2 1 2 Negative Genetic, Negative Genetic
DST1 YGL043W General transcription elongation factor TFIIS genetic 2 1 2 Negative Genetic, Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
PRI1 YIR008C Subunit of DNA primase genetic 2 1 2 Negative Genetic, Negative Genetic
RFC5 YBR087W Subunit of heteropentameric Replication factor C (RF-C) genetic 2 1 2 Negative Genetic, Negative Genetic
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 2 1 2 Negative Genetic, Negative Genetic
PDB1 YBR221C E1 beta subunit of the pyruvate dehydrogenase (PDH) complex genetic 2 1 2 Negative Genetic, Negative Genetic
SAM37 YMR060C Component of the Sorting and Assembly Machinery (SAM) complex genetic 2 1 2 Negative Genetic, Negative Genetic
ESC2 YDR363W Sumo-like domain protein genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 2 1 2 Negative Genetic, Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 2 1 2 Negative Genetic, Negative Genetic
CMC1 YKL137W Copper-binding protein of the mitochondrial intermembrane space genetic 2 1 2 Negative Genetic, Negative Genetic
MET22 YOL064C Bisphosphate-3'-nucleotidase genetic 2 1 2 Positive Genetic, Positive Genetic
KCH1 YJR054W Potassium transporter that mediates K+ influx genetic 2 1 2 Negative Genetic, Negative Genetic
SRS2 YJL092W DNA helicase and DNA-dependent ATPase physical 2 2 1 Reconstituted Complex, Two-hybrid
CRP1 YHR146W Protein that binds to cruciform DNA structures physical 2 2 1 Reconstituted Complex, Affinity Capture-Western
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 2 1 Negative Genetic, Positive Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 2 2 1 Negative Genetic, Positive Genetic
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CDC9 YDL164C DNA ligase I found in nucleus and mitochondria genetic 2 1 1 Negative Genetic, Negative Genetic
CTF4 YPR135W Chromatin-associated protein genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease physical 2 1 1 Reconstituted Complex, Reconstituted Complex
PEX12 YMR026C C3HC4-type RING-finger peroxin and E3 ubiquitin ligase genetic 2 1 1 Negative Genetic, Negative Genetic
RIM13 YMR154C Calpain-like cysteine protease genetic 2 1 1 Negative Genetic, Negative Genetic
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway genetic 2 1 1 Negative Genetic, Negative Genetic
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 2 1 1 Negative Genetic, Negative Genetic
NSE1 YLR007W Component of the SMC5-SMC6 complex genetic 2 1 1 Negative Genetic, Negative Genetic
CCS1 YMR038C Copper chaperone for superoxide dismutase Sod1p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
STP1 YDR463W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MSN1 YOL116W Transcriptional activator regulation 1 1 1 DNA to cDNA expression microarray evidence
YAP5 YIR018W Basic leucine zipper (bZIP) iron-sensing transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
HAL9 YOL089C Putative transcription factor containing a zinc finger regulation 1 1 1 DNA to cDNA expression microarray evidence
ARG81 YML099C Zinc finger transcription factor involved in arginine-responsive genes regulation 1 1 1 DNA to cDNA expression microarray evidence
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
ERB1 YMR049C Constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
CAB3 YKL088W Subunit of PPCDC and CoA-SPC complexes involved in CoA biosynthesis physical 1 1 1 Affinity Capture-MS
KRE29 YER038C Subunit of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
LOC1 YFR001W Nucleolar protein involved in the asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-MS
MES1 YGR264C Methionyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
CDC33 YOL139C Translation initiation factor eIF4E physical 1 1 1 Affinity Capture-MS
DIS3 YOL021C Exosome core complex catalytic subunit physical 1 1 1 Affinity Capture-MS
KAP95 YLR347C Karyopherin beta genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Synthetic Growth Defect
AOS1 YPR180W Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Uba2p genetic 1 1 1 Negative Genetic
ARO1 YDR127W Pentafunctional arom protein physical 1 1 1 Affinity Capture-MS
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 1 1 1 Positive Genetic
CDC14 YFR028C Protein phosphatase required for mitotic exit genetic 1 1 1 Negative Genetic
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex physical 1 1 1 Affinity Capture-MS
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex genetic 1 1 1 Positive Genetic
CDC16 YKL022C Subunit of the anaphase-promoting complex/cyclosome (APC/C) physical 1 1 1 Affinity Capture-MS
BDF2 YDL070W Protein involved in transcription initiation genetic 1 1 1 Negative Genetic
HHF1 YBR009C Histone H4 physical 1 1 1 Affinity Capture-MS
ISW2 YOR304W ATP-dependent DNA translocase involved in chromatin remodeling physical 1 1 1 Affinity Capture-MS
KRE33 YNL132W Acetyltransferase required for biogenesis of small ribosomal subunit physical 1 1 1 Affinity Capture-MS
GEA2 YEL022W Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs) physical 1 1 1 Affinity Capture-MS
LSM4 YER112W Lsm (Like Sm) protein physical 1 1 1 Two-hybrid
MRPL1 YDR116C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MGM101 YJR144W Protein with a role in mitochondrial DNA recombinational repair physical 1 1 1 Affinity Capture-MS
MUM2 YBR057C Protein essential for meiotic DNA replication and sporulation genetic 1 1 1 Negative Genetic
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Synthetic Growth Defect
MKT1 YNL085W Protein similar to nucleases that forms a complex with Pbp1p physical 1 1 1 Affinity Capture-MS
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
HOS4 YIL112W Subunit of the Set3 complex genetic 1 1 1 Negative Genetic
GAL83 YER027C One of three alternate beta-subunits of the Snf1 kinase complex physical 1 1 1 Affinity Capture-MS
FPR3 YML074C Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase) physical 1 1 1 Affinity Capture-MS
BBC1 YJL020C Protein possibly involved in assembly of actin patches physical 1 1 1 Two-hybrid
ADH2 YMR303C Glucose-repressible alcohol dehydrogenase II physical 1 1 1 Affinity Capture-MS
GRH1 YDR517W Acetylated cis-Golgi protein, homolog of human GRASP65 physical 1 1 1 Affinity Capture-MS
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Synthetic Growth Defect
GYP5 YPL249C GTPase-activating protein (GAP) for yeast Rab family members physical 1 1 1 Affinity Capture-MS
KRI1 YNL308C Essential nucleolar protein required for 40S ribosome biogenesis physical 1 1 1 Affinity Capture-MS
CAC2 YML102W Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p genetic 1 1 1 Negative Genetic
MAG1 YER142C 3-methyl-adenine DNA glycosylase genetic 1 1 1 Negative Genetic
HHO1 YPL127C Histone H1, linker histone with roles in meiosis and sporulation physical 1 1 1 Affinity Capture-MS
DPB11 YJL090C DNA replication initiation protein genetic 1 1 1 Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 1 1 1 Synthetic Growth Defect
KIC1 YHR102W Protein kinase of the PAK/Ste20 family, required for cell integrity physical 1 1 1 Affinity Capture-MS
ICP55 YER078C Mitochondrial aminopeptidase physical 1 1 1 Affinity Capture-MS
CLB2 YPR119W B-type cyclin involved in cell cycle progression physical 1 1 1 Two-hybrid
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 1 1 1 Synthetic Growth Defect
NHP2 YDL208W Protein related to mammalian high mobility group (HMG) proteins physical 1 1 1 Affinity Capture-MS
YHB1 YGR234W Nitric oxide oxidoreductase physical 1 1 1 Affinity Capture-MS
NOP2 YNL061W rRNA m5C methyltransferase physical 1 1 1 Affinity Capture-MS
RPC10 YHR143W-A RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III physical 1 1 1 Affinity Capture-MS
UBI4 YLL039C Ubiquitin physical 1 1 1 Affinity Capture-MS
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-MS
NOP12 YOL041C Nucleolar protein involved in pre-25S rRNA processing physical 1 1 1 Affinity Capture-MS
PWP1 YLR196W Protein with WD-40 repeats involved in rRNA processing physical 1 1 1 Affinity Capture-MS
RAD53 YPL153C DNA damage response kinase physical 1 1 1 Affinity Capture-MS
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Negative Genetic
SEC23 YPR181C GTPase-activating protein, stimulates the GTPase activity of Sar1p physical 1 1 1 Affinity Capture-MS
UTP22 YGR090W Component of the small-subunit processome physical 1 1 1 Affinity Capture-MS
RPF2 YKR081C Essential protein involved in rRNA maturation and ribosomal assembly physical 1 1 1 Affinity Capture-MS
TAF14 YPL129W Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes physical 1 1 1 Affinity Capture-MS
NUG1 YER006W GTPase that associates with nuclear 60S pre-ribosomes physical 1 1 1 Affinity Capture-MS
YMR226C YMR226C NADP(+)-dependent serine dehydrogenase and carbonyl reductase physical 1 1 1 Affinity Capture-MS
RVS167 YDR388W Calmodulin-binding actin-associated protein physical 1 1 1 Two-hybrid
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) physical 1 1 1 Reconstituted Complex
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 1 1 1 Negative Genetic
RFC2 YJR068W Subunit of heteropentameric Replication factor C (RF-C) physical 1 1 1 Reconstituted Complex
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) physical 1 1 1 Reconstituted Complex
RAD52 YML032C Protein involved in homologous recombination physical 1 1 1 Reconstituted Complex
TFG1 YGR186W TFIIF (Transcription Factor II) largest subunit physical 1 1 1 Affinity Capture-MS
QNS1 YHR074W Glutamine-dependent NAD(+) synthetase physical 1 1 1 Affinity Capture-MS
SKO1 YNL167C Basic leucine zipper transcription factor of the ATF/CREB family physical 1 1 1 Affinity Capture-MS
POL3 YDL102W Catalytic subunit of DNA polymerase delta physical 1 1 1 Affinity Capture-MS
SPC110 YDR356W Inner plaque spindle pole body (SPB) component physical 1 1 1 Affinity Capture-MS
RPS17B YDR447C Ribosomal protein 51 (rp51) of the small (40s) subunit physical 1 1 1 Affinity Capture-MS
OSH2 YDL019C Member of an oxysterol-binding protein family with seven members physical 1 1 1 Affinity Capture-MS
VPS54 YDR027C Component of the GARP (Golgi-associated retrograde protein) complex physical 1 1 1 Affinity Capture-MS
TPS3 YMR261C Regulatory subunit of trehalose-6-phosphate synthase/phosphatase physical 1 1 1 Affinity Capture-MS
SAP190 YKR028W Protein that forms a complex with the Sit4p protein phosphatase physical 1 1 1 Affinity Capture-MS
SEC2 YNL272C Guanyl-nucleotide exchange factor for the small G-protein Sec4p physical 1 1 1 Affinity Capture-MS
NUP1 YOR098C FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 Affinity Capture-MS
RIM15 YFL033C Protein kinase involved in cell proliferation in response to nutrients physical 1 1 1 Affinity Capture-MS
VPS5 YOR069W Nexin-1 homolog physical 1 1 1 Affinity Capture-MS
PEP8 YJL053W Vacuolar protein component of the retromer physical 1 1 1 Affinity Capture-MS
RKM4 YDR257C Ribosomal lysine methyltransferase physical 1 1 1 Affinity Capture-MS
YIL108W YIL108W Putative metalloendopeptidase physical 1 1 1 Affinity Capture-MS
RPL35A YDL191W Ribosomal 60S subunit protein L35A physical 1 1 1 Affinity Capture-MS
PSK1 YAL017W PAS domain-containing serine/threonine protein kinase physical 1 1 1 Affinity Capture-MS
TOP2 YNL088W Topoisomerase II genetic 1 1 1 Synthetic Growth Defect
RAD10 YML095C Single-stranded DNA endonuclease (with Rad1p) genetic 1 1 1 Phenotypic Enhancement
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
PGD1 YGL025C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SAP185 YJL098W Protein that forms a complex with the Sit4p protein phosphatase genetic 1 1 1 Negative Genetic
RSC58 YLR033W Component of the RSC chromatin remodeling complex genetic 1 1 1 Positive Genetic
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Synthetic Growth Defect
SPO13 YHR014W Meiotic regulator genetic 1 1 1 Synthetic Rescue
SPO11 YHL022C Meiosis-specific protein required for meiotic recombination genetic 1 1 1 Synthetic Rescue
RAD3 YER171W 5' to 3' DNA helicase genetic 1 1 1 Synthetic Growth Defect
SKN7 YHR206W Nuclear response regulator and transcription factor genetic 1 1 1 Synthetic Growth Defect
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Growth Defect
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Synthetic Growth Defect
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 1 1 1 Synthetic Growth Defect
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 1 1 1 Synthetic Growth Defect
SEN1 YLR430W ATP-dependent 5' to 3' RNA/DNA and DNA helicase genetic 1 1 1 Synthetic Growth Defect
ZIM17 YNL310C Protein co-chaperone with a zinc finger motif genetic 1 1 1 Phenotypic Enhancement
SBA1 YKL117W Co-chaperone that binds and regulates Hsp90 family chaperones genetic 1 1 1 Synthetic Lethality
RAD59 YDL059C Protein involved DNA double-strand break repair genetic 1 1 1 Positive Genetic
PSY3 YLR376C Component of Shu complex (aka PCSS complex) genetic 1 1 1 Positive Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Negative Genetic
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 1 1 1 Synthetic Growth Defect
RTT109 YLL002W Histone acetyltransferase genetic 1 1 1 Synthetic Growth Defect
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 1 1 1 Negative Genetic
RFC1 YOR217W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
PSF2 YJL072C Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 1 1 1 Negative Genetic
PRI2 YKL045W Subunit of DNA primase genetic 1 1 1 Negative Genetic
ULP1 YPL020C Protease that specifically cleaves Smt3p protein conjugates genetic 1 1 1 Negative Genetic
NPL4 YBR170C Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase genetic 1 1 1 Negative Genetic
THR4 YCR053W Threonine synthase genetic 1 1 1 Negative Genetic
SLM3 YDL033C tRNA-specific 2-thiouridylase genetic 1 1 1 Negative Genetic
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Negative Genetic
SST2 YLR452C GTPase-activating protein for Gpa1p genetic 1 1 1 Negative Genetic
PET127 YOR017W Protein with a role in 5'-end processing of mitochondrial RNAs genetic 1 1 1 Negative Genetic
YGR016W YGR016W Putative protein of unknown function genetic 1 1 1 Negative Genetic
SNX4 YJL036W Sorting nexin genetic 1 1 1 Negative Genetic
YNL108C YNL108C Protein phosphatase genetic 1 1 1 Negative Genetic
SPR1 YOR190W Sporulation-specific exo-1,3-beta-glucanase genetic 1 1 1 Negative Genetic
UBP7 YIL156W Ubiquitin-specific protease that cleaves ubiquitin-protein fusions genetic 1 1 1 Synthetic Growth Defect
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 1 1 1 Negative Genetic
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 1 1 1 Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Negative Genetic
UBP6 YFR010W Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Positive Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Negative Genetic
SLD3 YGL113W Protein involved in the initiation of DNA replication genetic 1 1 1 Negative Genetic
UBA4 YHR111W E1-like protein that activates Urm1p before urmylation genetic 1 1 1 Positive Genetic
TAF6 YGL112C Subunit (60 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
TEF4 YKL081W Gamma subunit of translational elongation factor eEF1B genetic 1 1 1 Negative Genetic
RNH201 YNL072W Ribonuclease H2 catalytic subunit genetic 1 1 1 Negative Genetic
SRV2 YNL138W CAP (cyclase-associated protein) genetic 1 1 1 Negative Genetic
SAW1 YAL027W 5'- and 3'-flap DNA binding protein genetic 1 1 1 Synthetic Growth Defect
SLX1 YBR228W Endonuclease involved in DNA recombination and repair genetic 1 1 1 Synthetic Growth Defect
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 1 1 1 Positive Genetic
SHU1 YHL006C Component of Shu complex (aka PCSS complex) genetic 1 1 1 Negative Genetic
CSM2 YIL132C Subunit of the Shu complex (aka PCSS complex) genetic 1 1 1 Negative Genetic
CLN3 YAL040C G1 cyclin involved in cell cycle progression genetic 1 1 1 Negative Genetic
BIM1 YER016W Microtubule plus end-tracking protein genetic 1 1 1 Negative Genetic
CSM3 YMR048W Replication fork associated factor genetic 1 1 1 Negative Genetic
COG6 YNL041C Component of the conserved oligomeric Golgi complex physical 1 1 1 Affinity Capture-MS
AMD1 YML035C AMP deaminase physical 1 1 1 Affinity Capture-MS
BRE5 YNR051C Ubiquitin protease cofactor genetic 1 1 1 Negative Genetic
CRP1 YHR146W Protein that binds to cruciform DNA structures genetic 1 1 1 Dosage Rescue
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 1 1 1 Negative Genetic
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
MOT2 YER068W Ubiquitin-protein ligase subunit of the CCR4-NOT complex physical 1 1 1 Affinity Capture-MS
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 1 1 1 Negative Genetic
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 1 1 1 Synthetic Growth Defect
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
KAR3 YPR141C Minus-end-directed microtubule motor genetic 1 1 1 Negative Genetic
MAD1 YGL086W Coiled-coil protein involved in spindle-assembly checkpoint physical 1 1 1 Affinity Capture-MS
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity physical 1 1 1 Affinity Capture-MS
ESC2 YDR363W Sumo-like domain protein physical 1 1 1 Reconstituted Complex
GYL1 YMR192W Putative GTPase activating protein (GAP) with a role in exocytosis physical 1 1 1 Affinity Capture-MS
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 1 1 1 Synthetic Growth Defect
KEX2 YNL238W Kexin, a subtilisin-like protease (proprotein convertase) genetic 1 1 1 Negative Genetic
BUG1 YDL099W Cis-golgi localized protein involved in ER to Golgi transport physical 1 1 1 Affinity Capture-MS
CAT2 YML042W Carnitine acetyl-CoA transferase genetic 1 1 1 Negative Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
EFM6 YNL024C Putative S-adenosylmethionine-dependent lysine methyltransferase physical 1 1 1 Two-hybrid
IRC5 YFR038W Putative ATPase containing the DEAD/H helicase-related sequence motif genetic 1 1 1 Negative Genetic
MGR3 YMR115W Subunit of the mitochondrial (mt) i-AAA protease supercomplex genetic 1 1 1 Negative Genetic
EST2 YLR318W Reverse transcriptase subunit of the telomerase holoenzyme genetic 1 1 1 Synthetic Growth Defect
MET7 YOR241W Folylpolyglutamate synthetase genetic 1 1 1 Negative Genetic
MSA1 YOR066W Activator of G1-specific transcription factors MBF and SBF genetic 1 1 1 Negative Genetic
CRD1 YDL142C Cardiolipin synthase genetic 1 1 1 Negative Genetic
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 1 1 1 Negative Genetic