| RAD53 |
YPL153C |
DNA damage response kinase |
physical |
27 |
7 |
23 |
Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Protein-peptide, Protein-peptide, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Biochemical Activity, Co-purification, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Biochemical Activity, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
| CDC13 |
YDL220C |
Single stranded DNA-binding protein found at TG1-3 telomere G-tails |
genetic |
26 |
6 |
22 |
Synthetic Rescue, Synthetic Rescue, Synthetic Lethality, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Lethality, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Synthetic Growth Defect, Positive Genetic, Synthetic Rescue, Synthetic Rescue |
| MRC1 |
YCL061C |
S-phase checkpoint protein required for DNA replication |
genetic |
22 |
5 |
15 |
Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Synthetic Lethality, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Rescue, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality |
| SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
15 |
4 |
10 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Growth Defect |
| RAD27 |
YKL113C |
5' to 3' exonuclease, 5' flap endonuclease |
genetic |
15 |
4 |
10 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Phenotypic Suppression, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic |
| TOF1 |
YNL273W |
Subunit of a replication-pausing checkpoint complex |
genetic |
14 |
4 |
11 |
Synthetic Lethality, Phenotypic Enhancement, Synthetic Lethality, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect |
| CTF18 |
YMR078C |
Subunit of a complex with Ctf8p |
genetic |
14 |
4 |
10 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Phenotypic Enhancement |
| DPB11 |
YJL090C |
DNA replication initiation protein |
physical |
14 |
4 |
8 |
Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Protein-peptide, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western |
| RAD5 |
YLR032W |
DNA helicase/Ubiquitin ligase |
genetic |
13 |
3 |
9 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect |
| DCC1 |
YCL016C |
Subunit of a complex with Ctf8p and Ctf18p |
genetic |
13 |
4 |
8 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Enhancement |
| CSM3 |
YMR048W |
Replication fork associated factor |
genetic |
12 |
3 |
7 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| CTF8 |
YHR191C |
Subunit of a complex with Ctf18p |
genetic |
11 |
3 |
6 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| RAD53 |
YPL153C |
DNA damage response kinase |
genetic |
10 |
4 |
9 |
Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue, Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect |
| EXO1 |
YOR033C |
5'-3' exonuclease and flap-endonuclease |
genetic |
10 |
4 |
9 |
Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue, Synthetic Growth Defect |
| DIA2 |
YOR080W |
Origin-binding F-box protein |
genetic |
10 |
4 |
8 |
Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Growth Defect, Negative Genetic |
| POL32 |
YJR043C |
Third subunit of DNA polymerase delta |
genetic |
10 |
3 |
6 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| RAD18 |
YCR066W |
E3 ubiquitin ligase |
genetic |
9 |
4 |
9 |
Phenotypic Suppression, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic |
| DUN1 |
YDL101C |
Cell-cycle checkpoint S/T protein kinase |
genetic |
9 |
4 |
8 |
Negative Genetic, Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| RAD24 |
YER173W |
Checkpoint protein |
genetic |
8 |
4 |
8 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue |
| SAE2 |
YGL175C |
Endonuclease required for telomere elongation |
genetic |
8 |
3 |
7 |
Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression |
| ELG1 |
YOR144C |
Subunit of an alternative replication factor C complex |
genetic |
7 |
4 |
6 |
Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Negative Genetic |
| SRS2 |
YJL092W |
DNA helicase and DNA-dependent ATPase |
genetic |
7 |
4 |
6 |
Phenotypic Enhancement, Negative Genetic, Negative Genetic, Phenotypic Suppression, Phenotypic Suppression, Negative Genetic, Synthetic Lethality |
| RTT107 |
YHR154W |
BRCA1 C-terminal domain protein needed for recovery from DNA damage |
genetic |
7 |
3 |
6 |
Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue |
| DNA2 |
YHR164C |
ATP-dependent 5'-flap endonuclease and DNA helicase |
genetic |
7 |
2 |
6 |
Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue |
| MCM2 |
YBL023C |
Protein involved in DNA replication |
genetic |
7 |
4 |
5 |
Phenotypic Enhancement, Negative Genetic, Synthetic Rescue, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement |
| MEC1 |
YBR136W |
Genome integrity checkpoint protein and PI kinase superfamily member |
genetic |
6 |
4 |
6 |
Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression, Negative Genetic, Negative Genetic, Synthetic Growth Defect |
| CDC9 |
YDL164C |
DNA ligase I found in nucleus and mitochondria |
genetic |
6 |
4 |
6 |
Synthetic Rescue, Phenotypic Enhancement, Phenotypic Suppression, Negative Genetic, Phenotypic Suppression, Negative Genetic |
| DPB11 |
YJL090C |
DNA replication initiation protein |
genetic |
6 |
3 |
6 |
Phenotypic Enhancement, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
| YKU70 |
YMR284W |
Subunit of the telomeric Ku complex (Yku70p-Yku80p) |
genetic |
6 |
3 |
6 |
Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue |
| POL3 |
YDL102W |
Catalytic subunit of DNA polymerase delta |
genetic |
6 |
4 |
5 |
Negative Genetic, Phenotypic Suppression, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| SIC1 |
YLR079W |
Cyclin-dependent kinase inhibitor (CKI) |
genetic |
6 |
2 |
5 |
Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Suppression, Negative Genetic, Negative Genetic |
| SLX4 |
YLR135W |
Endonuclease involved in processing DNA |
genetic |
6 |
2 |
4 |
Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression |
| RAD9 |
YDR217C |
DNA damage-dependent checkpoint protein |
physical |
6 |
4 |
3 |
Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Affinity Capture-Western |
| HST3 |
YOR025W |
Sirtuin, histone H3 deacetylase |
genetic |
5 |
3 |
5 |
Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Rescue, Synthetic Rescue |
| SML1 |
YML058W |
Ribonucleotide reductase inhibitor |
genetic |
5 |
1 |
5 |
Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue |
| RAD55 |
YDR076W |
Protein that stimulates strand exchange |
genetic |
5 |
3 |
4 |
Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement |
| TEL1 |
YBL088C |
Protein kinase primarily involved in telomere length regulation |
genetic |
5 |
3 |
4 |
Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue |
| MMS2 |
YGL087C |
Ubiquitin-conjugating enzyme variant |
genetic |
5 |
4 |
3 |
Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue |
| RAD52 |
YML032C |
Protein involved in homologous recombination |
genetic |
4 |
3 |
4 |
Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression |
| MRE11 |
YMR224C |
Nuclease subunit of the MRX complex with Rad50p and Xrs2p |
genetic |
4 |
3 |
4 |
Phenotypic Suppression, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue |
| HST4 |
YDR191W |
NAD(+)-dependent protein deacetylase |
genetic |
4 |
3 |
4 |
Negative Genetic, Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue |
| POL1 |
YNL102W |
Catalytic subunit of the DNA polymerase I alpha-primase complex |
genetic |
4 |
2 |
4 |
Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect |
| MEC3 |
YLR288C |
DNA damage and meiotic pachytene checkpoint protein |
genetic |
4 |
2 |
4 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression |
| CDC45 |
YLR103C |
DNA replication initiation factor |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| ORC2 |
YBR060C |
Subunit of the origin recognition complex (ORC) |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| CDC6 |
YJL194W |
Essential ATP-binding protein required for DNA replication |
genetic |
4 |
2 |
3 |
Dosage Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| CDC7 |
YDL017W |
S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) |
genetic |
4 |
2 |
3 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| REV3 |
YPL167C |
Catalytic subunit of DNA polymerase zeta |
genetic |
4 |
2 |
3 |
Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect |
| RIF1 |
YBR275C |
Protein involved in control of DNA replication |
genetic |
4 |
2 |
3 |
Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue |
| PSY3 |
YLR376C |
Component of Shu complex (aka PCSS complex) |
genetic |
4 |
2 |
3 |
Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement |
| AFT1 |
YGL071W |
Transcription factor involved in iron utilization and homeostasis |
physical |
4 |
3 |
1 |
Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Co-localization |
| POL2 |
YNL262W |
Catalytic subunit of DNA polymerase (II) epsilon |
genetic |
3 |
3 |
3 |
Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement |
| RAD51 |
YER095W |
Strand exchange protein |
genetic |
3 |
3 |
3 |
Synthetic Rescue, Phenotypic Suppression, Synthetic Growth Defect |
| RAD1 |
YPL022W |
Single-stranded DNA endonuclease (with Rad10p) |
genetic |
3 |
3 |
3 |
Phenotypic Suppression, Phenotypic Enhancement, Synthetic Lethality |
| RFC1 |
YOR217W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
3 |
3 |
3 |
Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic |
| RTT101 |
YJL047C |
Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex |
genetic |
3 |
3 |
3 |
Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement |
| RRM3 |
YHR031C |
DNA helicase involved in rDNA replication and Ty1 transposition |
genetic |
3 |
3 |
3 |
Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Enhancement |
| PIF1 |
YML061C |
DNA helicase, potent G-quadruplex DNA binder/unwinder |
genetic |
3 |
3 |
3 |
Phenotypic Enhancement, Dosage Growth Defect, Negative Genetic |
| DPB3 |
YBR278W |
Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) |
genetic |
3 |
2 |
3 |
Negative Genetic, Phenotypic Enhancement, Negative Genetic |
| FUN30 |
YAL019W |
Snf2p family member with ATP-dependent chromatin remodeling activity |
genetic |
3 |
2 |
3 |
Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue |
| POL30 |
YBR088C |
Proliferating cell nuclear antigen (PCNA) |
genetic |
3 |
2 |
3 |
Phenotypic Enhancement, Negative Genetic, Phenotypic Enhancement |
| RAD6 |
YGL058W |
Ubiquitin-conjugating enzyme (E2) |
genetic |
3 |
2 |
3 |
Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression |
| STN1 |
YDR082W |
Telomere end-binding and capping protein |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect |
| SLX5 |
YDL013W |
Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex |
genetic |
3 |
2 |
3 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic |
| PRI1 |
YIR008C |
Subunit of DNA primase |
genetic |
3 |
2 |
3 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| CHK1 |
YBR274W |
Serine/threonine kinase and DNA damage checkpoint effector |
physical |
3 |
1 |
3 |
Two-hybrid, Two-hybrid, Two-hybrid |
| MMS21 |
YEL019C |
Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex |
genetic |
3 |
3 |
2 |
Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Suppression |
| ASF1 |
YJL115W |
Nucleosome assembly factor |
genetic |
3 |
3 |
2 |
Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect |
| HTA1 |
YDR225W |
Histone H2A |
genetic |
3 |
3 |
2 |
Synthetic Growth Defect, Synthetic Lethality, Phenotypic Suppression |
| PPH3 |
YDR075W |
Catalytic subunit of protein phosphatase PP4 complex |
genetic |
3 |
2 |
2 |
Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression |
| DDC1 |
YPL194W |
DNA damage checkpoint protein |
genetic |
3 |
2 |
2 |
Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement |
| CTF4 |
YPR135W |
Chromatin-associated protein |
genetic |
3 |
2 |
2 |
Phenotypic Suppression, Phenotypic Suppression, Synthetic Lethality |
| SET1 |
YHR119W |
Histone methyltransferase, subunit of the COMPASS (Set1C) complex |
genetic |
3 |
2 |
2 |
Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression |
| REV1 |
YOR346W |
Deoxycytidyl transferase |
genetic |
3 |
2 |
2 |
Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic |
| POL31 |
YJR006W |
Subunit of DNA polymerase delta (polymerase III) |
genetic |
3 |
2 |
2 |
Synthetic Rescue, Negative Genetic, Negative Genetic |
| MMS1 |
YPR164W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
genetic |
3 |
2 |
2 |
Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement |
| PSF1 |
YDR013W |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| TSA1 |
YML028W |
Thioredoxin peroxidase |
genetic |
3 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect |
| REV7 |
YIL139C |
Accessory subunit of DNA polymerase zeta |
genetic |
3 |
1 |
2 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement |
| UBC13 |
YDR092W |
E2 ubiquitin-conjugating enzyme |
genetic |
3 |
1 |
2 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement |
| ORC3 |
YLL004W |
Subunit of the origin recognition complex (ORC) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| RAD17 |
YOR368W |
Checkpoint protein |
genetic |
3 |
1 |
2 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement |
| CDC8 |
YJR057W |
Nucleoside monophosphate and nucleoside diphosphate kinase |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| IRC15 |
YPL017C |
Microtubule associated protein |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| MAC1 |
YMR021C |
Copper-sensing transcription factor |
physical |
3 |
3 |
1 |
Two-hybrid, Affinity Capture-Western, Reconstituted Complex |
| CDC14 |
YFR028C |
Protein phosphatase required for mitotic exit |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Negative Genetic |
| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
physical |
2 |
2 |
2 |
PCA, Biochemical Activity |
| DOA1 |
YKL213C |
WD-repeat protein involved in ubiquitin-mediated protein degradation |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Phenotypic Enhancement |
| MCM6 |
YGL201C |
Protein involved in DNA replication |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Negative Genetic |
| ORC1 |
YML065W |
Largest subunit of the origin recognition complex |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Negative Genetic |
| MGS1 |
YNL218W |
Protein with DNA-dependent ATPase and ssDNA annealing activities |
genetic |
2 |
2 |
2 |
Dosage Lethality, Phenotypic Suppression |
| CDC5 |
YMR001C |
Polo-like kinase required for mitotic exit |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Phenotypic Suppression |
| PDS1 |
YDR113C |
Securin |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Phenotypic Suppression |
| MCM4 |
YPR019W |
Essential helicase component of heterohexameric MCM2-7 complexes |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
| RFA1 |
YAR007C |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
| TAH11 |
YJR046W |
DNA replication licensing factor |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| WSS1 |
YHR134W |
SUMO-ligase and SUMO-targeted metalloprotease |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Synthetic Growth Defect |
| RTT109 |
YLL002W |
Histone acetyltransferase |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Synthetic Growth Defect |
| YKU80 |
YMR106C |
Subunit of telomeric Ku complex (Yku70p-Yku80p) |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Phenotypic Enhancement |
| RFC4 |
YOL094C |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Negative Genetic |
| SPE1 |
YKL184W |
Ornithine decarboxylase |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Positive Genetic |
| SRV2 |
YNL138W |
CAP (cyclase-associated protein) |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Positive Genetic |
| SAM1 |
YLR180W |
S-adenosylmethionine synthetase |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Phenotypic Suppression |
| DBF4 |
YDR052C |
Regulatory subunit of Cdc7p-Dbf4p kinase complex |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
| NMD2 |
YHR077C |
Protein involved in the nonsense-mediated mRNA decay (NMD) pathway |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Synthetic Rescue |
| NUT1 |
YGL151W |
Component of the RNA polymerase II mediator complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
2 |
1 |
2 |
Affinity Capture-RNA, Affinity Capture-RNA |
| CHK1 |
YBR274W |
Serine/threonine kinase and DNA damage checkpoint effector |
genetic |
2 |
1 |
2 |
Phenotypic Suppression, Phenotypic Suppression |
| RAD50 |
YNL250W |
Subunit of MRX complex with Mre11p and Xrs2p |
genetic |
2 |
1 |
2 |
Phenotypic Suppression, Phenotypic Suppression |
| TDP1 |
YBR223C |
Tyrosyl-DNA phosphodiesterase I |
genetic |
2 |
1 |
2 |
Phenotypic Enhancement, Phenotypic Enhancement |
| RFA2 |
YNL312W |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| TOP1 |
YOL006C |
Topoisomerase I |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
| SOK2 |
YMR016C |
Nuclear protein that negatively regulates pseudohyphal differentiation |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| APN1 |
YKL114C |
Major apurinic/apyrimidinic endonuclease |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
| PIG1 |
YLR273C |
Putative targeting subunit for type-1 protein phosphatase Glc7p |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
2 |
2 |
1 |
Positive Genetic, Negative Genetic |
| CDC55 |
YGL190C |
Regulatory subunit B of protein phosphatase 2A (PP2A) |
genetic |
2 |
2 |
1 |
Phenotypic Suppression, Synthetic Lethality |
| ISW2 |
YOR304W |
ATP-dependent DNA translocase involved in chromatin remodeling |
genetic |
2 |
2 |
1 |
Phenotypic Suppression, Synthetic Rescue |
| NHP10 |
YDL002C |
Non-essential INO80 chromatin remodeling complex subunit |
genetic |
2 |
2 |
1 |
Phenotypic Suppression, Synthetic Rescue |
| DOA4 |
YDR069C |
Ubiquitin hydrolase |
genetic |
2 |
2 |
1 |
Phenotypic Enhancement, Synthetic Rescue |
| HTA2 |
YBL003C |
Histone H2A |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Synthetic Lethality |
| IES4 |
YOR189W |
Component of the INO80 chromatiin remodeling complex |
genetic |
2 |
2 |
1 |
Phenotypic Enhancement, Synthetic Growth Defect |
| RTT106 |
YNL206C |
Histone chaperone |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Synthetic Rescue |
| SGV1 |
YPR161C |
Cyclin (Bur2p)-dependent protein kinase |
genetic |
2 |
2 |
1 |
Positive Genetic, Negative Genetic |
| PSF2 |
YJL072C |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| PAT1 |
YCR077C |
Deadenylation-dependent mRNA-decapping factor |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
| ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| MCM5 |
YLR274W |
Component of the Mcm2-7 hexameric helicase complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| BBC1 |
YJL020C |
Protein possibly involved in assembly of actin patches |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| RAD54 |
YGL163C |
DNA-dependent ATPase that stimulates strand exchange |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| MUS81 |
YDR386W |
Subunit of structure-specific Mms4p-Mus81p endonuclease |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| MMS4 |
YBR098W |
Subunit of structure-specific Mms4p-Mus81p endonuclease |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| MGT1 |
YDL200C |
DNA repair methyltransferase (6-O-methylguanine-DNA methylase) |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| RIM1 |
YCR028C-A |
ssDNA-binding protein essential for mitochondrial genome maintenance |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| UIP5 |
YKR044W |
Protein of unknown function that interacts with Ulp1p |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| SLD5 |
YDR489W |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SLD3 |
YGL113W |
Protein involved in the initiation of DNA replication |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| MCM7 |
YBR202W |
Component of the Mcm2-7 hexameric helicase complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| ESC2 |
YDR363W |
Sumo-like domain protein |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| IXR1 |
YKL032C |
Transcriptional repressor that regulates hypoxic genes during normoxia |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| MGR1 |
YCL044C |
Subunit of the mitochondrial (mt) i-AAA protease supercomplex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| POT1 |
YIL160C |
3-ketoacyl-CoA thiolase with broad chain length specificity |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| MSN1 |
YOL116W |
Transcriptional activator |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| AIM20 |
YIL158W |
Protein of unknown function |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| SFP1 |
YLR403W |
Regulates transcription of ribosomal protein and biogenesis genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| IXR1 |
YKL032C |
Transcriptional repressor that regulates hypoxic genes during normoxia |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| YAP6 |
YDR259C |
Basic leucine zipper (bZIP) transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| TFC7 |
YOR110W |
RNA pol III transcription initiation factor complex (TFIIIC) subunit |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
regulation |
1 |
1 |
1 |
quantitative mass spectrometry evidence |
| BFR2 |
YDR299W |
Component of the SSU and 90S preribosomes |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ARP4 |
YJL081C |
Nuclear actin-related protein involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MIA40 |
YKL195W |
Import and assembly protein in mitochondrial intermembrane space |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ECM2 |
YBR065C |
Pre-mRNA splicing factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NSE4 |
YDL105W |
Component of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BRE1 |
YDL074C |
E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NOC3 |
YLR002C |
Subunit of a nuclear complex with Noc2p and pre-replicative complexes |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MCM21 |
YDR318W |
Component of the kinetochore sub-complex COMA |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| MES1 |
YGR264C |
Methionyl-tRNA synthetase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| BMH1 |
YER177W |
14-3-3 protein, major isoform |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| NOP56 |
YLR197W |
Essential evolutionarily-conserved nucleolar protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NPL3 |
YDR432W |
RNA-binding protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| PSY2 |
YNL201C |
Subunit of protein phosphatase PP4 complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| HPR1 |
YDR138W |
Subunit of THO/TREX complexes |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| DST1 |
YGL043W |
General transcription elongation factor TFIIS |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| GCD1 |
YOR260W |
Gamma subunit of the translation initiation factor eIF2B |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRE10 |
YOR362C |
Alpha 7 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ALA1 |
YOR335C |
Cytoplasmic and mitochondrial alanyl-tRNA synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| ECM16 |
YMR128W |
Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| CDC14 |
YFR028C |
Protein phosphatase required for mitotic exit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CDC11 |
YJR076C |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CDC12 |
YHR107C |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CEG1 |
YGL130W |
Guanylyltransferase involved in mRNA 5' capping |
genetic |
1 |
1 |
1 |
Negative Genetic |
| COX6 |
YHR051W |
Subunit VI of cytochrome c oxidase (Complex IV) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ERO1 |
YML130C |
Thiol oxidase required for oxidative protein folding in the ER |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ESP1 |
YGR098C |
Separase/separin, a caspase-like cysteine protease |
genetic |
1 |
1 |
1 |
Positive Genetic |
| HHF2 |
YNL030W |
Histone H4 |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| DPB4 |
YDR121W |
Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ACK1 |
YDL203C |
Protein that functions in the cell wall integrity pathway |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| CRM1 |
YGR218W |
Nuclear export factor, exportin |
genetic |
1 |
1 |
1 |
Positive Genetic |
| LCB1 |
YMR296C |
Component of serine palmitoyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LSM7 |
YNL147W |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MED11 |
YMR112C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ATG26 |
YLR189C |
UDP-glucose:sterol glucosyltransferase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| MRP51 |
YPL118W |
Mitochondrial ribosomal protein of the small subunit |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| MEC1 |
YBR136W |
Genome integrity checkpoint protein and PI kinase superfamily member |
physical |
1 |
1 |
1 |
Biochemical Activity |
| MPH1 |
YIR002C |
3'-5' DNA helicase involved in error-free bypass of DNA lesions |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| CMR1 |
YDL156W |
Nuclear protein with role in transcription, protein quality control |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MYO2 |
YOR326W |
Type V myosin motor involved in actin-based transport of cargos |
genetic |
1 |
1 |
1 |
Positive Genetic |
| GIN4 |
YDR507C |
Protein kinase involved in bud growth and assembly of the septin ring |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| HTZ1 |
YOL012C |
Histone variant H2AZ |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| NUP116 |
YMR047C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NUP60 |
YAR002W |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| GIM3 |
YNL153C |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| POL12 |
YBL035C |
B subunit of DNA polymerase alpha-primase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRE4 |
YFR050C |
Beta 7 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Positive Genetic |
| HTA1 |
YDR225W |
Histone H2A |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| DAM1 |
YGR113W |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PTC3 |
YBL056W |
Type 2C protein phosphatase (PP2C) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| NRP1 |
YDL167C |
Putative RNA binding protein of unknown function |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| HTA2 |
YBL003C |
Histone H2A |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| PDC1 |
YLR044C |
Major of three pyruvate decarboxylase isozymes |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| MET18 |
YIL128W |
Component of cytosolic iron-sulfur protein assembly (CIA) machinery |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD3 |
YER171W |
5' to 3' DNA helicase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RAD52 |
YML032C |
Protein involved in homologous recombination |
physical |
1 |
1 |
1 |
Co-localization |
| MED8 |
YBR193C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PPH21 |
YDL134C |
Catalytic subunit of protein phosphatase 2A, PP2A |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| NUP84 |
YDL116W |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DUG1 |
YFR044C |
Cys-Gly metallo-di-peptidase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| PRP9 |
YDL030W |
Subunit of the SF3a splicing factor complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GCN5 |
YGR252W |
Catalytic subunit of ADA and SAGA histone acetyltransferase complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MNN4 |
YKL201C |
Putative positive regulator of mannosylphosphate transferase Mnn6p |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| PIN4 |
YBL051C |
Protein involved in G2/M phase progression and response to DNA damage |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| PYC2 |
YBR218C |
Pyruvate carboxylase isoform |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| HYP2 |
YEL034W |
Translation elongation factor eIF-5A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC5 |
YMR001C |
Polo-like kinase required for mitotic exit |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| PLN1 |
YKR046C |
Perilipin, involved in formation and stability of lipid droplets |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| DMA2 |
YNL116W |
Ubiquitin-protein ligase (E3) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| BUB2 |
YMR055C |
Mitotic exit network regulator |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| HIR3 |
YJR140C |
Subunit of the HIR complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ARO4 |
YBR249C |
3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| DUN1 |
YDL101C |
Cell-cycle checkpoint S/T protein kinase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| DIP5 |
YPL265W |
Dicarboxylic amino acid permease |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ATG11 |
YPR049C |
Adapter protein for pexophagy and the Cvt targeting pathway |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ERG27 |
YLR100W |
3-keto sterol reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MRS6 |
YOR370C |
Rab escort protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| DMA1 |
YHR115C |
Ubiquitin-protein ligase (E3) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| ELM1 |
YKL048C |
Serine/threonine protein kinase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| LSB1 |
YGR136W |
Negative regulator of actin nucleation-promoting factor activity |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| CDC4 |
YFL009W |
F-box protein required for both the G1/S and G2/M phase transitions |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| HIR1 |
YBL008W |
Subunit of the HIR complex |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| GPG1 |
YGL121C |
Proposed gamma subunit of the heterotrimeric G protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| CAC2 |
YML102W |
Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| EMI2 |
YDR516C |
Hexokinase expressed during growth with low glucose levels |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| HHT1 |
YBR010W |
Histone H3 |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| LHS1 |
YKL073W |
Molecular chaperone of the endoplasmic reticulum lumen |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| FPK1 |
YNR047W |
Ser/Thr protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CIK1 |
YMR198W |
Kinesin-associated protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MIH1 |
YMR036C |
Protein tyrosine phosphatase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| CLB2 |
YPR119W |
B-type cyclin involved in cell cycle progression |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CLB2 |
YPR119W |
B-type cyclin involved in cell cycle progression |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| RAD7 |
YJR052W |
Nucleotide excision repair (NER) protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| DEF1 |
YKL054C |
RNAPII degradation factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GCR2 |
YNL199C |
Transcriptional activator of genes involved in glycolysis |
genetic |
1 |
1 |
1 |
Positive Genetic |
| APE2 |
YKL157W |
Aminopeptidase yscII |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| CDH1 |
YGL003C |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| BIR1 |
YJR089W |
Subunit of chromosomal passenger complex (CPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ERG11 |
YHR007C |
Lanosterol 14-alpha-demethylase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NUP133 |
YKR082W |
Subunit of Nup84p subcomplex of nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| APL4 |
YPR029C |
Gamma-adaptin |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| KKQ8 |
YKL168C |
Putative serine/threonine protein kinase with unknown cellular role |
genetic |
1 |
1 |
1 |
Positive Genetic |
| IME2 |
YJL106W |
Serine/threonine protein kinase involved in activation of meiosis |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| DID4 |
YKL002W |
Class E Vps protein of the ESCRT-III complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ATG13 |
YPR185W |
Regulatory subunit of the Atg1p signaling complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| AFT1 |
YGL071W |
Transcription factor involved in iron utilization and homeostasis |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| MOB2 |
YFL034C-B |
Activator of Cbk1p kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MAD2 |
YJL030W |
Component of the spindle-assembly checkpoint complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MSH5 |
YDL154W |
Protein of the MutS family |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| HSP10 |
YOR020C |
Mitochondrial matrix co-chaperonin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PKC1 |
YBL105C |
Protein serine/threonine kinase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CDC34 |
YDR054C |
Ubiquitin-conjugating enzyme (E2) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PET191 |
YJR034W |
Protein required for assembly of cytochrome c oxidase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| FOB1 |
YDR110W |
Nucleolar protein that binds the rDNA replication fork barrier site |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| AIM18 |
YHR198C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PPA2 |
YMR267W |
Mitochondrial inorganic pyrophosphatase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| GPN2 |
YOR262W |
Putative GTPase with a specific role in RNA pol II and polIII biogenes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NST1 |
YNL091W |
Translational inhibitor and suppressor of proteasome-assembly defects |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC26 |
YFR036W |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| GCR1 |
YPL075W |
Transcriptional activator of genes involved in glycolysis |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| LEU3 |
YLR451W |
Zinc-knuckle transcription factor, repressor and activator |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| NOT5 |
YPR072W |
Component of the CCR4-NOT core complex, involved in mRNA decapping |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| CSE4 |
YKL049C |
Centromeric histone H3-like protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RLF2 |
YPR018W |
Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| RPD3 |
YNL330C |
Histone deacetylase, component of both the Rpd3S and Rpd3L complexes |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| SIN3 |
YOL004W |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| XRS2 |
YDR369C |
FHA domain-containing component of the Mre11 complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| TAF14 |
YPL129W |
Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ROX3 |
YBL093C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RVB1 |
YDR190C |
ATP-dependent DNA helicase, also known as pontin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SLX8 |
YER116C |
Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RGP1 |
YDR137W |
Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTT105 |
YER104W |
Chaperone for Replication Protein A complex (RPA) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YKE2 |
YLR200W |
Subunit of the heterohexameric Gim/prefoldin protein complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RSC1 |
YGR056W |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YML119W |
YML119W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
| UBP3 |
YER151C |
Ubiquitin-specific protease that cleaves Ub-protein fusions |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SGF73 |
YGL066W |
Subunit of DUBm module of SAGA and SLIK |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SUA5 |
YGL169W |
Protein involved in threonylcarbamoyl adenosine biosynthesis |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| YPR015C |
YPR015C |
Putative zinc finger transcription factor |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| SPT4 |
YGR063C |
Spt4p/5p (DSIF) transcription elongation factor complex subunit |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| RFT1 |
YBL020W |
Membrane protein required for translocation of Man5GlcNac2-PP-Dol |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RPB9 |
YGL070C |
RNA polymerase II subunit B12.6 |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SIR4 |
YDR227W |
SIR protein involved in assembly of silent chromatin domains |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SPP2 |
YOR148C |
Essential protein that promotes the first step of splicing |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SFG1 |
YOR315W |
Nuclear protein putative transcription factor |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| URM1 |
YIL008W |
Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| TRP1 |
YDR007W |
Phosphoribosylanthranilate isomerase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SUT2 |
YPR009W |
Zn2Cys6 family transcription factor |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| YCK1 |
YHR135C |
Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| YBR012W-B |
YBR012W-B |
Retrotransposon TYA Gag and TYB Pol genes |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| TOM1 |
YDR457W |
E3 ubiquitin ligase of the hect-domain class |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SEA4 |
YBL104C |
Subunit of SEACAT, a subcomplex of the SEA complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| THI21 |
YPL258C |
Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| YMR181C |
YMR181C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SWI1 |
YPL016W |
Subunit of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| STU2 |
YLR045C |
Microtubule polymerase of the XMAP215/Dis1 family |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| YPK1 |
YKL126W |
S/T protein kinase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SMY2 |
YBR172C |
GYF domain protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SMC4 |
YLR086W |
Subunit of the condensin complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| VMA2 |
YBR127C |
Subunit B of V1 peripheral membrane domain of vacuolar H+-ATPase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| RLI1 |
YDR091C |
Essential Fe-S protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| TEA1 |
YOR337W |
Ty1 enhancer activator involved in Ty enhancer-mediated transcription |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SEC6 |
YIL068C |
Essential 88kDa subunit of the exocyst complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| TRX1 |
YLR043C |
Cytoplasmic thioredoxin isoenzyme |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SSK1 |
YLR006C |
Cytoplasmic phosphorelay intermediate osmosensor and regulator |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| TMA17 |
YDL110C |
Regulatory gamma subunit of fatty acid synthase (FAS) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SRB8 |
YCR081W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SWE1 |
YJL187C |
Protein kinase that regulates the G2/M transition |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| UBP11 |
YKR098C |
Ubiquitin-specific protease |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| UTP22 |
YGR090W |
Component of the small-subunit processome |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| TSC11 |
YER093C |
Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| YLR154C-G |
YLR154C-G |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| YBR259W |
YBR259W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SPO71 |
YDR104C |
Meiosis-specific protein required for prospore membrane morphogenesis |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| YAR009C |
YAR009C |
Retrotransposon TYA Gag and TYB Pol genes |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SEC15 |
YGL233W |
Essential 113 kDa subunit of the exocyst complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| RPL12B |
YDR418W |
Ribosomal 60S subunit protein L12B |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| RPO21 |
YDL140C |
RNA polymerase II largest subunit B220 |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SPO12 |
YHR152W |
Nucleolar protein of unknown function |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| RTR2 |
YDR066C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| VBA2 |
YBR293W |
Permease of basic amino acids in the vacuolar membrane |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| TUB2 |
YFL037W |
Beta-tubulin |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SNT2 |
YGL131C |
Subunit of Snt2C complex, RING finger ubiquitin ligase (E3) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| TPO5 |
YKL174C |
Protein involved in excretion of putrescine and spermidine |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| YEL077C |
YEL077C |
Helicase-like protein encoded within the telomeric Y' element |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| TPM2 |
YIL138C |
Minor isoform of tropomyosin |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SNF3 |
YDL194W |
Plasma membrane low glucose sensor, regulates glucose transport |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| YGL081W |
YGL081W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| VNX1 |
YNL321W |
Calcium/H+ antiporter localized to the endoplasmic reticulum membrane |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SWH1 |
YAR042W |
Protein similar to mammalian oxysterol-binding protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SOR1 |
YJR159W |
Sorbitol dehydrogenase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ROG1 |
YGL144C |
Lipase with specificity for monoacylglycerol |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SNU66 |
YOR308C |
Component of the U4/U6.U5 snRNP complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| TIM11 |
YDR322C-A |
Subunit e of mitochondrial F1F0-ATPase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SYF1 |
YDR416W |
Member of the NineTeen Complex (NTC) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SPE4 |
YLR146C |
Spermine synthase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| THI13 |
YDL244W |
Protein involved in synthesis of the thiamine precursor HMP |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| RPP1A |
YDL081C |
Ribosomal stalk protein P1 alpha |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VMA3 |
YEL027W |
Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWI4 |
YER111C |
DNA binding component of the SBF complex (Swi4p-Swi6p) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SLT2 |
YHR030C |
Serine/threonine MAP kinase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SEC22 |
YLR268W |
R-SNARE protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RNR4 |
YGR180C |
Ribonucleotide-diphosphate reductase (RNR) small subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SOD1 |
YJR104C |
Cytosolic copper-zinc superoxide dismutase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SMC6 |
YLR383W |
Subunit of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SIZ1 |
YDR409W |
SUMO E3 ligase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SIR2 |
YDL042C |
Conserved NAD+ dependent histone deacetylase of the Sirtuin family |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ULP2 |
YIL031W |
Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| REI1 |
YBR267W |
Cytoplasmic pre-60S factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTG3 |
YBL103C |
bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YTA12 |
YMR089C |
Mitochondrial inner membrane m-AAA protease component |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VMA11 |
YPL234C |
Vacuolar ATPase V0 domain subunit c' |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YME1 |
YPR024W |
Catalytic subunit of i-AAA protease complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RDH54 |
YBR073W |
DNA-dependent ATPase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| TPP1 |
YMR156C |
DNA 3'-phosphatase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TOP3 |
YLR234W |
DNA Topoisomerase III |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SNU71 |
YGR013W |
Component of U1 snRNP required for mRNA splicing via spliceosome |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SEC13 |
YLR208W |
Structural component of 3 complexes |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SEC39 |
YLR440C |
Component of the Dsl1p tethering complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SEC63 |
YOR254C |
Essential subunit of Sec63 complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| TFC8 |
YPL007C |
Subunit of RNA polymerase III transcription initiation factor complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SEC62 |
YPL094C |
Essential subunit of Sec63 complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| YIH1 |
YCR059C |
Negative regulator of eIF2 kinase Gcn2p |
genetic |
1 |
1 |
1 |
Positive Genetic |
| YHR210C |
YHR210C |
Putative aldose 1-epimerase superfamily protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SEC20 |
YDR498C |
Membrane glycoprotein v-SNARE |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RFA3 |
YJL173C |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAF5 |
YBR198C |
Subunit (90 kDa) of TFIID and SAGA complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TSC13 |
YDL015C |
Enoyl reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SMT3 |
YDR510W |
Ubiquitin-like protein of the SUMO family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SRM1 |
YGL097W |
Nucleotide exchange factor for Gsp1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RFC2 |
YJR068W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| URA6 |
YKL024C |
Uridylate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SED5 |
YLR026C |
cis-Golgi t-SNARE syntaxin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEC12 |
YNR026C |
Guanine nucleotide exchange factor (GEF) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TBF1 |
YPL128C |
Telobox-containing general regulatory factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SAT4 |
YCR008W |
Ser/Thr protein kinase involved in salt tolerance, nutrient response |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YCR102C |
YCR102C |
Putative quinone oxidoreductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SHS1 |
YDL225W |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTG2 |
YGL252C |
Sensor of mitochondrial dysfunction |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SNF6 |
YHL025W |
Subunit of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAS2 |
YNL098C |
GTP-binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| URH1 |
YDR400W |
Uridine nucleosidase (uridine-cytidine N-ribohydrolase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTR1 |
YER139C |
Dual specificity protein phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TUS1 |
YLR425W |
Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RNR1 |
YER070W |
Major isoform of large subunit of ribonucleotide-diphosphate reductase |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| SMA2 |
YML066C |
Meiosis-specific prospore membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YET2 |
YMR040W |
Protein of unknown function that may interact with ribosomes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPS18 |
YNL204C |
Protein of unknown function, contains a putative zinc-binding domain |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL20B |
YOR312C |
Ribosomal 60S subunit protein L20B |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWI6 |
YLR182W |
Transcription cofactor |
genetic |
1 |
1 |
1 |
Positive Genetic |
| UBP12 |
YJL197W |
Ubiquitin-specific protease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPE2 |
YOL052C |
S-adenosylmethionine decarboxylase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| UBA1 |
YKL210W |
Ubiquitin activating enzyme (E1) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| YEN1 |
YER041W |
Holliday junction resolvase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| SAM2 |
YDR502C |
S-adenosylmethionine synthetase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| RMI1 |
YPL024W |
Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| CLB5 |
YPR120C |
B-type cyclin involved in DNA replication during S phase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| DBP5 |
YOR046C |
Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| DCD1 |
YHR144C |
Deoxycytidine monophosphate (dCMP) deaminase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FRQ1 |
YDR373W |
N-myristoylated calcium-binding protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| GCD10 |
YNL062C |
Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HOP1 |
YIL072W |
Meiosis-specific protein required for chromosome synapsis |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| IOC4 |
YMR044W |
Member of a complex (Isw1b) with Isw1p and Ioc2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KAR9 |
YPL269W |
Spindle positioning factor |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| MCM3 |
YEL032W |
Protein involved in DNA replication |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD17 |
YOR368W |
Checkpoint protein |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| MST28 |
YAR033W |
Putative integral membrane protein, involved in vesicle formation |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| RAD2 |
YGR258C |
Single-stranded DNA endonuclease |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| CHS3 |
YBR023C |
Chitin synthase III |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| DOT1 |
YDR440W |
Nucleosomal histone H3-Lys79 methylase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| BPT1 |
YLL015W |
ABC type transmembrane transporter of MRP/CFTR family |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| IVY1 |
YDR229W |
Phospholipid-binding protein that interacts with both Ypt7p and Vps33p |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ORC5 |
YNL261W |
Subunit of the origin recognition complex (ORC) |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| CLA4 |
YNL298W |
Cdc42p-activated signal transducing kinase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| GTT1 |
YIR038C |
ER associated glutathione S-transferase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| HHT2 |
YNL031C |
Histone H3 |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| APN2 |
YBL019W |
Class II abasic (AP) endonuclease involved in repair of DNA damage |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MSL5 |
YLR116W |
Component of commitment complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| HAC1 |
YFL031W |
Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| PRS4 |
YBL068W |
5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DBP6 |
YNR038W |
Essential protein involved in ribosome biogenesis |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ERV14 |
YGL054C |
COPII-coated vesicle protein |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| AUS1 |
YOR011W |
Plasma membrane sterol transporter of the ATP-binding cassette family |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| PIH1 |
YHR034C |
Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ORC6 |
YHR118C |
Subunit of the origin recognition complex (ORC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| JHD2 |
YJR119C |
JmjC domain family histone demethylase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| GDA1 |
YEL042W |
Guanosine diphosphatase located in the Golgi |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| GPI2 |
YPL076W |
Protein involved in the synthesis of GlcNAc-PI |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BOL3 |
YAL046C |
Protein involved in Fe-S cluster transfer to mitochondrial clients |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NGR1 |
YBR212W |
RNA binding protein that negatively regulates growth rate |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| PBP4 |
YDL053C |
Pbp1p binding protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| PUS9 |
YDL036C |
Mitochondrial tRNA:pseudouridine synthase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| BPH1 |
YCR032W |
Protein homologous to Chediak-Higashi syndrome and Beige proteins |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| KCS1 |
YDR017C |
Inositol hexakisphosphate and inositol heptakisphosphate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| JIP4 |
YDR475C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| OCA4 |
YCR095C |
Cytoplasmic protein required for replication of Brome mosaic virus |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ORC4 |
YPR162C |
Subunit of the origin recognition complex (ORC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| INA22 |
YIR024C |
F1F0 ATP synthase peripheral stalk assembly factor |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| FLO11 |
YIR019C |
GPI-anchored cell surface glycoprotein (flocculin) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| PRC1 |
YMR297W |
Vacuolar carboxypeptidase Y (proteinase C, CPY) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| PRI2 |
YKL045W |
Subunit of DNA primase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MRPL27 |
YBR282W |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OCA5 |
YHL029C |
Cytoplasmic protein required for replication of Brome mosaic virus |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| EUG1 |
YDR518W |
Protein disulfide isomerase of the endoplasmic reticulum lumen |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| OTU2 |
YHL013C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ECM7 |
YLR443W |
Putative integral membrane protein with a role in calcium uptake |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| PAN5 |
YHR063C |
2-dehydropantoate 2-reductase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| PKP2 |
YGL059W |
Mitochondrial protein kinase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| NCR1 |
YPL006W |
Vacuolar membrane protein involved with Npc2p in sterol trafficking |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RAD57 |
YDR004W |
Protein that stimulates strand exchange |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| EST2 |
YLR318W |
Reverse transcriptase subunit of the telomerase holoenzyme |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| OSW1 |
YOR255W |
Protein involved in sporulation |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| PHD1 |
YKL043W |
Transcriptional activator that enhances pseudohyphal growth |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ENA1 |
YDR040C |
P-type ATPase sodium pump |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ENA2 |
YDR039C |
P-type ATPase sodium pump |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ENA5 |
YDR038C |
Protein with similarity to P-type ATPase sodium pumps |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| PRY1 |
YJL079C |
Lipid binding protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| LDB18 |
YLL049W |
Component of the dynactin complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| LGE1 |
YPL055C |
Protein involved in histone H2B ubiquitination |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| HER2 |
YMR293C |
Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KRE9 |
YJL174W |
Glycoprotein involved in cell wall beta-glucan assembly |
genetic |
1 |
1 |
1 |
Positive Genetic |
| OAC1 |
YKL120W |
Mitochondrial inner membrane transporter |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| NRE1 |
YIR035C |
Putative cytoplasmic short-chain dehydrogenase/reductase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ISC1 |
YER019W |
Inositol phosphosphingolipid phospholipase C |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| PFA4 |
YOL003C |
Palmitoyltransferase with autoacylation activity |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| AFB1 |
YLR040C |
MATalpha-specific a-factor blocker |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| FLO9 |
YAL063C |
Lectin-like protein with similarity to Flo1p |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| COX13 |
YGL191W |
Subunit VIa of cytochrome c oxidase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| NDD1 |
YOR372C |
Transcriptional activator essential for nuclear division |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| LCB4 |
YOR171C |
Sphingoid long-chain base kinase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ERG9 |
YHR190W |
Farnesyl-diphosphate farnesyl transferase (squalene synthase) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| GPI10 |
YGL142C |
Integral membrane protein involved in GPI anchor synthesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MSC1 |
YML128C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| COS5 |
YJR161C |
Endosomal protein involved in turnover of plasma membrane proteins |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DFR1 |
YOR236W |
Dihydrofolate reductase involved in tetrahydrofolate biosynthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AGP1 |
YCL025C |
Broad-specificity, low-affinity amino acid permease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PMP3 |
YDR276C |
Small plasma membrane protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MCH2 |
YKL221W |
Protein with similarity to mammalian monocarboxylate permeases |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| CIN10 |
YDR387C |
Putative transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NFT1 |
YKR103W |
Putative transporter of the MRP subfamily |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| NPR3 |
YHL023C |
Subunit of the Iml1p/SEACIT complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| DBR1 |
YKL149C |
RNA lariat debranching enzyme |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| LDH1 |
YBR204C |
Serine hydrolase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| DML1 |
YMR211W |
Essential protein involved in mtDNA inheritance |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| DPA10 |
YLR307C-A |
Putative mitochondrial protein of unknown function |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| NPP1 |
YCR026C |
Nucleotide pyrophosphatase/phosphodiesterase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| CDA2 |
YLR308W |
Chitin deacetylase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
