Standard name Systematic name Name description Description
FOB1 YDR110W Nucleolar protein that binds the rDNA replication fork barrier site Nucleolar protein that binds the rDNA replication fork barrier site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to replication fork barrier (RFB), and rDNA repeat segregation; related to retroviral integrases
Visualize the interactome of FOB1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Mito 0.085 NaN NaN
Nucleolus 0.814 0.774 0.702
Nucleus 0.156 0.136 0.194
SpindlePole 0.397 0.480 0.726
Endosome NaN 0.051 NaN

GFP localization & abundance

GFP localization GFP abundance
nucleolus 1510

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
FOB1 4 0 0 0 2

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 18 4 17 Phenotypic Suppression, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression
NET1 YJL076W Core subunit of the RENT complex physical 7 4 5 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Two-hybrid, Two-hybrid, Reconstituted Complex
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family physical 6 3 5 Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Two-hybrid
NSI1 YDR026C RNA polymerase I termination factor physical 6 3 4 Two-hybrid, Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Two-hybrid
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 4 3 4 Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Negative Genetic
TOF2 YKR010C Protein required for rDNA silencing and mitotic rDNA condensation physical 4 3 3 Affinity Capture-MS, Affinity Capture-MS, Co-localization, Two-hybrid
CTF4 YPR135W Chromatin-associated protein genetic 4 2 3 Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 4 2 3 Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue
SMC2 YFR031C Subunit of the condensin complex genetic 3 2 3 Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality
YCS4 YLR272C Subunit of the condensin complex genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
SMC6 YLR383W Subunit of the SMC5-SMC6 complex genetic 3 2 3 Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression
FOB1 YDR110W Nucleolar protein that binds the rDNA replication fork barrier site physical 3 1 3 Two-hybrid, Two-hybrid, Two-hybrid
SPO12 YHR152W Nucleolar protein of unknown function physical 3 2 2 Two-hybrid, Affinity Capture-Western, Two-hybrid
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CDC14 YFR028C Protein phosphatase required for mitotic exit physical 2 2 2 Affinity Capture-Western, Affinity Capture-MS
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 2 2 2 Phenotypic Suppression, Synthetic Rescue
RPA49 YNL248C RNA polymerase I subunit A49 genetic 2 2 2 Synthetic Rescue, Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 2 2 2 Phenotypic Enhancement, Synthetic Rescue
TOP2 YNL088W Topoisomerase II genetic 2 2 2 Negative Genetic, Phenotypic Suppression
BRN1 YBL097W Subunit of the condensin complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
APE3 YBR286W Vacuolar aminopeptidase Y genetic 2 1 2 Negative Genetic, Negative Genetic
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase genetic 2 1 2 Negative Genetic, Negative Genetic
RIF1 YBR275C Protein involved in control of DNA replication genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 2 2 1 Phenotypic Suppression, Dosage Growth Defect
EST2 YLR318W Reverse transcriptase subunit of the telomerase holoenzyme genetic 2 2 1 Synthetic Rescue, Synthetic Growth Defect
HXK2 YGL253W Hexokinase isoenzyme 2 genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
GPA2 YER020W Nucleotide binding alpha subunit of the heterotrimeric G protein genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
MSN2 YMR037C Stress-responsive transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Phenotypic Suppression
CDC14 YFR028C Protein phosphatase required for mitotic exit genetic 1 1 1 Phenotypic Enhancement
ATP11 YNL315C Molecular chaperone genetic 1 1 1 Negative Genetic
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex genetic 1 1 1 Phenotypic Suppression
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator genetic 1 1 1 Phenotypic Suppression
END3 YNL084C EH domain-containing protein involved in endocytosis genetic 1 1 1 Negative Genetic
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
CMD1 YBR109C Calmodulin genetic 1 1 1 Negative Genetic
CAC2 YML102W Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p genetic 1 1 1 Phenotypic Suppression
AFG3 YER017C Mitochondrial inner membrane m-AAA protease component genetic 1 1 1 Phenotypic Enhancement
ARP1 YHR129C Actin-related protein of the dynactin complex genetic 1 1 1 Synthetic Lethality
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I physical 1 1 1 Co-localization
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 1 1 1 Phenotypic Suppression
SPT2 YER161C Protein involved in negative regulation of transcription physical 1 1 1 Two-hybrid
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) physical 1 1 1 Two-hybrid
LSM5 YER146W Lsm (Like Sm) protein physical 1 1 1 Two-hybrid
PRP8 YHR165C Component of U4/U6-U5 snRNP complex physical 1 1 1 Two-hybrid
SLU7 YDR088C RNA splicing factor physical 1 1 1 Two-hybrid
MUD1 YBR119W U1 snRNP A protein physical 1 1 1 Two-hybrid
SNP1 YIL061C Component of U1 snRNP required for mRNA splicing via spliceosome physical 1 1 1 Two-hybrid
MCM6 YGL201C Protein involved in DNA replication physical 1 1 1 Two-hybrid
HTB1 YDR224C Histone H2B physical 1 1 1 Affinity Capture-MS
HTB2 YBL002W Histone H2B physical 1 1 1 Affinity Capture-MS
TOP1 YOL006C Topoisomerase I physical 1 1 1 Affinity Capture-MS
TOP1 YOL006C Topoisomerase I genetic 1 1 1 Synthetic Growth Defect
NOG1 YPL093W Putative GTPase physical 1 1 1 Affinity Capture-MS
REB1 YBR049C RNA polymerase I enhancer binding protein physical 1 1 1 Affinity Capture-MS
HHO1 YPL127C Histone H1, linker histone with roles in meiosis and sporulation physical 1 1 1 Affinity Capture-MS
HTA1 YDR225W Histone H2A physical 1 1 1 Affinity Capture-MS
HTA2 YBL003C Histone H2A physical 1 1 1 Affinity Capture-MS
HHF1 YBR009C Histone H4 physical 1 1 1 Affinity Capture-MS
HHF2 YNL030W Histone H4 physical 1 1 1 Affinity Capture-MS
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression physical 1 1 1 Affinity Capture-MS
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
ORC1 YML065W Largest subunit of the origin recognition complex physical 1 1 1 Affinity Capture-MS
GRR1 YJR090C F-box protein component of an SCF ubiquitin-ligase complex physical 1 1 1 Two-hybrid
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
HPR1 YDR138W Subunit of THO/TREX complexes genetic 1 1 1 Phenotypic Enhancement
MDH1 YKL085W Mitochondrial malate dehydrogenase genetic 1 1 1 Phenotypic Suppression
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 1 1 1 Phenotypic Enhancement
POP4 YBR257W Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Negative Genetic
HSP60 YLR259C Tetradecameric mitochondrial chaperonin genetic 1 1 1 Negative Genetic
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 1 1 1 Negative Genetic
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Synthetic Growth Defect
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Phenotypic Suppression
RET1 YOR207C Second-largest subunit of RNA polymerase III genetic 1 1 1 Dosage Rescue
RTT109 YLL002W Histone acetyltransferase genetic 1 1 1 Phenotypic Suppression
UBP9 YER098W Ubiquitin-specific protease that cleaves ubiquitin-protein fusions genetic 1 1 1 Positive Genetic
YPL039W YPL039W Putative protein of unknown function genetic 1 1 1 Positive Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
YCG1 YDR325W Subunit of the condensin complex genetic 1 1 1 Negative Genetic
NAR1 YNL240C Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery genetic 1 1 1 Negative Genetic
SDS24 YBR214W Protein involved in cell separation during budding genetic 1 1 1 Negative Genetic
RGT2 YDL138W Plasma membrane high glucose sensor that regulates glucose transport genetic 1 1 1 Negative Genetic
LRP1 YHR081W Nuclear exosome-associated nucleic acid binding protein genetic 1 1 1 Negative Genetic
RRP6 YOR001W Nuclear exosome exonuclease component genetic 1 1 1 Negative Genetic
SDP1 YIL113W Stress-inducible dual-specificity MAP kinase phosphatase genetic 1 1 1 Negative Genetic
HOC1 YJR075W Alpha-1,6-mannosyltransferase genetic 1 1 1 Negative Genetic
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Phenotypic Enhancement
SPT7 YBR081C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Phenotypic Suppression
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains genetic 1 1 1 Phenotypic Enhancement
MRPL10 YNL284C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
WSC3 YOL105C Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway genetic 1 1 1 Negative Genetic
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) genetic 1 1 1 Phenotypic Suppression
MSI1 YBR195C Subunit of chromatin assembly factor I (CAF-1) genetic 1 1 1 Phenotypic Suppression
PBP1 YGR178C Component of glucose deprivation induced stress granules genetic 1 1 1 Phenotypic Suppression
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 1 1 1 Phenotypic Suppression
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 1 1 1 Phenotypic Suppression
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Synthetic Rescue
NSE5 YML023C Component of the SMC5-SMC6 complex genetic 1 1 1 Phenotypic Suppression
HST1 YOL068C NAD(+)-dependent histone deacetylase genetic 1 1 1 Phenotypic Suppression
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation genetic 1 1 1 Phenotypic Suppression
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 1 1 1 Two-hybrid
DOC1 YGL240W Processivity factor genetic 1 1 1 Phenotypic Suppression
ECO1 YFR027W Acetyltransferase required for sister chromatid cohesion genetic 1 1 1 Phenotypic Suppression
ATG2 YNL242W Peripheral membrane protein required for autophagic vesicle formation genetic 1 1 1 Negative Genetic
ALG1 YBR110W Mannosyltransferase genetic 1 1 1 Negative Genetic
CGI121 YML036W Component of the EKC/KEOPS complex genetic 1 1 1 Phenotypic Enhancement
FMS1 YMR020W Polyamine oxidase genetic 1 1 1 Negative Genetic
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
CMI7 YIL002W-A Putative mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
ECM4 YKR076W S-glutathionyl-(chloro)hydroquinone reductase (GS-HQR) genetic 1 1 1 Negative Genetic
AAT1 YKL106W Mitochondrial aspartate aminotransferase genetic 1 1 1 Phenotypic Suppression
DDI3 YFL061W Cyanamide hydratase that detoxifies cyanamide genetic 1 1 1 Negative Genetic