Standard name Systematic name Name description Description
SMC2 YFR031C Subunit of the condensin complex Subunit of the condensin complex; condensin reorganizes chromosomes during both mitosis and meiosis; essential SMC chromosomal ATPase family member that forms a subcomplex with Smc2p that has ATP-hydrolyzing and DNA-binding activity, but other condensin subunits are required for chromatin binding; required for clustering of tRNA genes at the nucleolus
Visualize the interactome of SMC2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
S 61

CYCLoPs localization & abundance

WT1 WT2 WT3
Nucleolus 0.121 0.092 NaN
Nucleus 0.808 0.815 0.864
Mito NaN 0.077 0.352

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 3290

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SMC2 0 6 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SMC4 YLR086W Subunit of the condensin complex physical 7 5 5 Affinity Capture-Western, Reconstituted Complex, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Co-crystal Structure
YCG1 YDR325W Subunit of the condensin complex physical 4 2 4 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS
FOB1 YDR110W Nucleolar protein that binds the rDNA replication fork barrier site genetic 3 2 3 Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality
BRN1 YBL097W Subunit of the condensin complex physical 3 2 3 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
SGO1 YOR073W Component of the spindle checkpoint physical 3 2 2 Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western
FKH1 YIL131C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence
YCS4 YLR272C Subunit of the condensin complex physical 2 2 2 Affinity Capture-Western, Affinity Capture-MS
SMC3 YJL074C Subunit of the multiprotein cohesin complex physical 2 2 2 Two-hybrid, Affinity Capture-MS
BRN1 YBL097W Subunit of the condensin complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
TOF2 YKR010C Protein required for rDNA silencing and mitotic rDNA condensation genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
NUP100 YKL068W FG-nucleoporin component of central core of the nuclear pore complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
HHF2 YNL030W Histone H4 genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
NDC80 YIL144W Component of the kinetochore-associated Ndc80 complex physical 2 2 1 Affinity Capture-Western, Two-hybrid
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 2 2 1 Synthetic Lethality, Phenotypic Enhancement
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 1 1 1 Affinity Capture-MS
HAS1 YMR290C ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
NOP2 YNL061W rRNA m5C methyltransferase genetic 1 1 1 Negative Genetic
RRP1 YDR087C Essential evolutionarily conserved nucleolar protein genetic 1 1 1 Positive Genetic
BRE1 YDL074C E3 ubiquitin ligase physical 1 1 1 Two-hybrid
CDC42 YLR229C Small rho-like GTPase genetic 1 1 1 Negative Genetic
NOP56 YLR197W Essential evolutionarily-conserved nucleolar protein genetic 1 1 1 Positive Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Positive Genetic
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-Western
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
ERG26 YGL001C C-3 sterol dehydrogenase genetic 1 1 1 Negative Genetic
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
MCD1 YDL003W Essential alpha-kleisin subunit of the cohesin complex genetic 1 1 1 Negative Genetic
MRPL1 YDR116C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Dosage Rescue
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 1 1 1 Negative Genetic
HTA1 YDR225W Histone H2A genetic 1 1 1 Synthetic Growth Defect
NOP14 YDL148C Nucleolar protein genetic 1 1 1 Negative Genetic
RAD52 YML032C Protein involved in homologous recombination genetic 1 1 1 Synthetic Growth Defect
PUP3 YER094C Beta 3 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
SEC63 YOR254C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 1 1 1 Synthetic Growth Defect
SMC1 YFL008W Subunit of the multiprotein cohesin complex physical 1 1 1 Two-hybrid
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
HTB1 YDR224C Histone H2B genetic 1 1 1 Synthetic Growth Defect
GSP1 YLR293C Ran GTPase genetic 1 1 1 Negative Genetic
ERG27 YLR100W 3-keto sterol reductase genetic 1 1 1 Negative Genetic
SKP1 YDR328C Evolutionarily conserved kinetochore protein genetic 1 1 1 Synthetic Lethality
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Positive Genetic
IPA1 YJR141W Protein implicated in pre-mRNA processing and proteasomal degradation genetic 1 1 1 Negative Genetic
GLE1 YDL207W Cytoplasmic nucleoporin required for polyadenylated mRNA export genetic 1 1 1 Negative Genetic
CIN8 YEL061C Bipolar kinesin motor protein genetic 1 1 1 Synthetic Lethality
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network genetic 1 1 1 Phenotypic Enhancement
HHT1 YBR010W Histone H3 physical 1 1 1 Affinity Capture-MS
CTF4 YPR135W Chromatin-associated protein genetic 1 1 1 Synthetic Lethality
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 1 1 1 Synthetic Lethality
PAP2 YOL115W Non-canonical poly(A) polymerase physical 1 1 1 Affinity Capture-MS
RTT103 YDR289C Protein involved in transcription termination by RNA polymerase II genetic 1 1 1 Synthetic Lethality
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) physical 1 1 1 Affinity Capture-MS
MAD3 YJL013C Subunit of spindle-assembly checkpoint complex genetic 1 1 1 Synthetic Lethality
NDC80 YIL144W Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Dosage Rescue
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Negative Genetic
CSM3 YMR048W Replication fork associated factor genetic 1 1 1 Synthetic Lethality
BRF1 YGR246C TFIIIB B-related factor physical 1 1 1 Affinity Capture-Western
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit physical 1 1 1 Affinity Capture-MS
SMC4 YLR086W Subunit of the condensin complex genetic 1 1 1 Synthetic Growth Defect
YCS4 YLR272C Subunit of the condensin complex genetic 1 1 1 Synthetic Lethality
SPC29 YPL124W Inner plaque spindle pole body (SPB) component physical 1 1 1 Two-hybrid
SRS2 YJL092W DNA helicase and DNA-dependent ATPase physical 1 1 1 Two-hybrid
STI1 YOR027W Evolutionarily-conserved Hsp90 cochaperone physical 1 1 1 Affinity Capture-MS
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation physical 1 1 1 Affinity Capture-MS
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
TUB2 YFL037W Beta-tubulin physical 1 1 1 Reconstituted Complex
TUB1 YML085C Alpha-tubulin physical 1 1 1 Reconstituted Complex
VID30 YGL227W Central component of GID Complex, involved in FBPase degradation physical 1 1 1 Affinity Capture-MS
VID24 YBR105C GID Complex regulatory subunit physical 1 1 1 Affinity Capture-MS
SMC6 YLR383W Subunit of the SMC5-SMC6 complex physical 1 1 1 Affinity Capture-MS
SMC6 YLR383W Subunit of the SMC5-SMC6 complex genetic 1 1 1 Synthetic Growth Defect
ULP2 YIL031W Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins genetic 1 1 1 Dosage Rescue
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Synthetic Lethality
TOP1 YOL006C Topoisomerase I genetic 1 1 1 Synthetic Lethality
SSD1 YDR293C Translational repressor genetic 1 1 1 Dosage Rescue
SNU56 YDR240C Component of U1 snRNP required for mRNA splicing via spliceosome genetic 1 1 1 Negative Genetic
SRP101 YDR292C Signal recognition particle (SRP) receptor alpha subunit genetic 1 1 1 Negative Genetic
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 1 1 1 Negative Genetic
TAD3 YLR316C Subunit of tRNA-specific adenosine-34 deaminase genetic 1 1 1 Negative Genetic
UTP15 YMR093W Nucleolar protein genetic 1 1 1 Negative Genetic
SRP54 YPR088C Signal recognition particle (SRP) subunit (homolog of mammalian SRP54) genetic 1 1 1 Negative Genetic
SPN1 YPR133C Protein involved in RNA polymerase II transcription genetic 1 1 1 Negative Genetic
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 1 1 1 Negative Genetic
KAR3 YPR141C Minus-end-directed microtubule motor genetic 1 1 1 Synthetic Lethality
MAD1 YGL086W Coiled-coil protein involved in spindle-assembly checkpoint genetic 1 1 1 Phenotypic Enhancement
MPS1 YDL028C Dual-specificity kinase genetic 1 1 1 Negative Genetic
PFY1 YOR122C Profilin genetic 1 1 1 Positive Genetic
HHT2 YNL031C Histone H3 physical 1 1 1 Affinity Capture-MS
RRS1 YOR294W Essential protein that binds ribosomal protein L11 genetic 1 1 1 Negative Genetic
KAR5 YMR065W Protein required for nuclear membrane fusion during karyogamy physical 1 1 1 Two-hybrid
SAC7 YDR389W GTPase activating protein (GAP) for Rho1p genetic 1 1 1 Synthetic Lethality
SEC39 YLR440C Component of the Dsl1p tethering complex genetic 1 1 1 Negative Genetic
SLK19 YOR195W Kinetochore-associated protein physical 1 1 1 Two-hybrid
ORC6 YHR118C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
ASE1 YOR058C Mitotic spindle midzone-localized microtubule bundling protein genetic 1 1 1 Synthetic Lethality
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
HIS2 YFR025C Histidinolphosphatase physical 1 1 1 Affinity Capture-MS
NOP19 YGR251W Ribosome biogenesis factor genetic 1 1 1 Dosage Rescue
RTC4 YNL254C Protein of unknown function genetic 1 1 1 Synthetic Lethality
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
CAB1 YDR531W Pantothenate kinase, ATP:D-pantothenate 4'-phosphotransferase genetic 1 1 1 Negative Genetic
SGO1 YOR073W Component of the spindle checkpoint genetic 1 1 1 Synthetic Lethality
EFG1 YGR271C-A Ribosome biogenesis factor required for maturation of 18S rRNA physical 1 1 1 Affinity Capture-MS
MOD5 YOR274W Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase physical 1 1 1 Affinity Capture-Western
IRC15 YPL017C Microtubule associated protein genetic 1 1 1 Synthetic Lethality
RIB2 YOL066C Bifunctional DRAP deaminase tRNA:pseudouridine synthase genetic 1 1 1 Negative Genetic