Standard name Systematic name Name description Description
CDC42 YLR229C Small rho-like GTPase Small rho-like GTPase; essential for establishment and maintenance of cell polarity; plays a role late in cell fusion via activation of key cell fusion regulator Fus2p; acts with ESCRT proteins at sites of nuclear envelope and ER fission; mutants have defects in the organization of actin and septins; human homolog CDC42 can complement yeast cdc42 mutant
Visualize the interactome of CDC42
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
CDC42 0 1 2 2 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
STE20 YHL007C Cdc42p-activated signal transducing kinase physical 20 4 18 Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Two-hybrid, Two-hybrid, Biochemical Activity, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western
BEM1 YBR200W Protein containing SH3-domains physical 12 4 8 Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Co-fractionation, Two-hybrid, Reconstituted Complex, Reconstituted Complex
CLA4 YNL298W Cdc42p-activated signal transducing kinase physical 11 4 11 Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, FRET
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 11 6 10 Synthetic Lethality, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Suppression, Dosage Rescue, Synthetic Lethality, Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Phenotypic Suppression, Negative Genetic
GIC1 YHR061C Rho-family GTPase interacting protein and Cdc42p effector physical 11 3 10 Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Two-hybrid, Reconstituted Complex
GIC2 YDR309C Rho-family GTPase interacting protein and Cdc42p effector physical 11 3 10 Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Two-hybrid, Reconstituted Complex
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 10 4 7 Dosage Rescue, Dosage Rescue, Synthetic Lethality, Dosage Rescue, Dosage Rescue, Dosage Rescue, Dosage Rescue, Phenotypic Suppression, Negative Genetic, Negative Genetic
RHO3 YIL118W Non-essential small GTPase of the Rho/Rac family of Ras-like proteins genetic 10 4 6 Dosage Lethality, Dosage Rescue, Dosage Rescue, Dosage Rescue, Dosage Rescue, Synthetic Lethality, Dosage Rescue, Dosage Rescue, Negative Genetic, Negative Genetic
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p physical 9 4 9 Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Biochemical Activity, Reconstituted Complex
MSB1 YOR188W Protein of unknown function genetic 8 3 8 Synthetic Lethality, Dosage Rescue, Dosage Rescue, Dosage Rescue, Dosage Rescue, Dosage Rescue, Synthetic Growth Defect, Dosage Rescue
BEM4 YPL161C Protein involved in establishment of cell polarity and bud emergence physical 8 4 7 Affinity Capture-MS, Two-hybrid, Two-hybrid, Two-hybrid, PCA, Two-hybrid, Reconstituted Complex, Two-hybrid
STE20 YHL007C Cdc42p-activated signal transducing kinase genetic 8 3 7 Dosage Rescue, Dosage Rescue, Dosage Rescue, Dosage Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression
GIC2 YDR309C Rho-family GTPase interacting protein and Cdc42p effector genetic 8 6 6 Synthetic Lethality, Dosage Rescue, Phenotypic Suppression, Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Lethality
BEM4 YPL161C Protein involved in establishment of cell polarity and bud emergence genetic 8 3 5 Synthetic Lethality, Dosage Rescue, Dosage Rescue, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
RGA1 YOR127W GTPase-activating protein for polarity-regulator Cdc42p (RhoGAP) physical 7 3 6 Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Biochemical Activity, Reconstituted Complex, Two-hybrid
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 7 3 6 Synthetic Lethality, Synthetic Lethality, Synthetic Rescue, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
RSR1 YGR152C Ras-type GTPase genetic 7 5 5 Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Synthetic Growth Defect, Negative Genetic, Phenotypic Suppression
BEM1 YBR200W Protein containing SH3-domains genetic 6 3 6 Synthetic Lethality, Dosage Rescue, Dosage Rescue, Dosage Rescue, Negative Genetic, Synthetic Lethality
MSB3 YNL293W Rab GTPase-activating protein genetic 6 4 5 Synthetic Lethality, Dosage Rescue, Synthetic Growth Defect, Synthetic Lethality, Dosage Rescue, Negative Genetic
SEC15 YGL233W Essential 113 kDa subunit of the exocyst complex genetic 6 3 5 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Negative Genetic, Negative Genetic
GIC1 YHR061C Rho-family GTPase interacting protein and Cdc42p effector genetic 6 4 3 Phenotypic Suppression, Phenotypic Enhancement, Dosage Rescue, Dosage Rescue, Phenotypic Suppression, Synthetic Lethality
RSR1 YGR152C Ras-type GTPase physical 6 2 3 Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex
SEC3 YER008C Subunit of the exocyst complex genetic 5 3 5 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Synthetic Growth Defect
SWF1 YDR126W Palmitoyltransferase that acts on transmembrane proteins genetic 5 3 5 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic
SRO7 YPR032W Effector of Rab GTPase Sec4p genetic 5 3 5 Dosage Rescue, Negative Genetic, Negative Genetic, Positive Genetic, Dosage Rescue
BNI1 YNL271C Formin physical 5 1 5 Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 5 3 4 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
CAP2 YIL034C Beta subunit of the capping protein heterodimer (Cap1p and Cap2p) genetic 5 3 4 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 5 2 4 Dosage Rescue, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BOI2 YER114C Protein involved in polar growth physical 5 3 3 Two-hybrid, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western
RDI1 YDL135C Rho GDP dissociation inhibitor physical 4 3 4 Two-hybrid, Affinity Capture-Western, FRET, Affinity Capture-Western
SPA2 YLL021W Component of the polarisome genetic 4 3 3 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic
SEC4 YFL005W Rab family GTPase genetic 4 2 3 Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Dosage Rescue
AIM44 YPL158C Regulator of Cdc42p and Rho1p physical 4 2 3 Two-hybrid, Affinity Capture-Western, Two-hybrid, Two-hybrid
CDC43 YGL155W Beta subunit of geranylgeranyltransferase type I genetic 4 3 2 Phenotypic Suppression, Phenotypic Enhancement, Negative Genetic, Negative Genetic
ELP3 YPL086C Subunit of Elongator complex genetic 3 3 3 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
SSD1 YDR293C Translational repressor genetic 3 3 3 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
CAP1 YKL007W Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p) genetic 3 3 3 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
SEC3 YER008C Subunit of the exocyst complex physical 3 2 3 Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western
IQG1 YPL242C Actin filament binding protein that enhances actin ring formation physical 3 2 3 Two-hybrid, Two-hybrid, PCA
CYK3 YDL117W SH3-domain protein located in the bud neck and cytokinetic actin ring genetic 3 2 3 Negative Genetic, Dosage Growth Defect, Negative Genetic
SKM1 YOL113W Member of the PAK family of serine/threonine protein kinases physical 3 1 3 Two-hybrid, Two-hybrid, Two-hybrid
BEM3 YPL115C Rho GTPase activating protein (RhoGAP) physical 3 1 3 Two-hybrid, Two-hybrid, Two-hybrid
RGA1 YOR127W GTPase-activating protein for polarity-regulator Cdc42p (RhoGAP) genetic 3 3 2 Dosage Rescue, Phenotypic Enhancement, Negative Genetic
BOI1 YBL085W Protein involved in polar growth, functionally redundant with Boi2p physical 3 3 2 Two-hybrid, PCA, Reconstituted Complex
AXL2 YIL140W Integral plasma membrane protein genetic 3 2 2 Dosage Rescue, Synthetic Growth Defect, Dosage Rescue
EXO70 YJL085W Subunit of the exocyst complex genetic 3 2 2 Synthetic Rescue, Negative Genetic, Negative Genetic
SEC9 YGR009C t-SNARE protein required for secretory vesicle-plasma membrane fusion genetic 3 2 2 Dosage Rescue, Synthetic Lethality, Synthetic Lethality
MSB2 YGR014W Mucin family member involved in various signaling pathways physical 3 3 1 Two-hybrid, Affinity Capture-Western, Reconstituted Complex
STE50 YCL032W Adaptor protein for various signaling pathways genetic 2 2 2 Phenotypic Suppression, Negative Genetic
KES1 YPL145C Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger genetic 2 2 2 Dosage Rescue, Negative Genetic
FUS2 YMR232W Cell fusion regulator physical 2 2 2 Reconstituted Complex, Co-localization
ELP2 YGR200C Subunit of Elongator complex genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
ELP4 YPL101W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
ELP6 YMR312W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
HUR1 YGL168W Protein with a role in DNA repair genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
UBA4 YHR111W E1-like protein that activates Urm1p before urmylation genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
NCS6 YGL211W Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
PCL1 YNL289W Cyclin, interacts with cyclin-dependent kinase Pho85p genetic 2 2 2 Phenotypic Enhancement, Synthetic Lethality
PCL2 YDL127W Cyclin, interacts with cyclin-dependent kinase Pho85p genetic 2 2 2 Phenotypic Enhancement, Synthetic Lethality
SEC2 YNL272C Guanyl-nucleotide exchange factor for the small G-protein Sec4p genetic 2 2 2 Synthetic Lethality, Dosage Rescue
GIN4 YDR507C Protein kinase involved in bud growth and assembly of the septin ring genetic 2 2 2 Phenotypic Enhancement, Dosage Rescue
SEC14 YMR079W Phosphatidylinositol/phosphatidylcholine transfer protein genetic 2 2 2 Dosage Rescue, Negative Genetic
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 2 2 2 Dosage Rescue, Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 2 2 2 Negative Genetic, Positive Genetic
HOF1 YMR032W F-BAR protein that regulates actin cytoskeleton organization genetic 2 2 2 Negative Genetic, Dosage Growth Defect
IRA2 YOL081W GTPase-activating protein genetic 2 2 2 Negative Genetic, Positive Genetic
MYO1 YHR023W Type II myosin heavy chain genetic 2 2 2 Dosage Growth Defect, Synthetic Rescue
LAS17 YOR181W Actin assembly factor genetic 2 2 2 Negative Genetic, Positive Genetic
BEM2 YER155C Rho GTPase activating protein (RhoGAP) physical 2 2 2 Biochemical Activity, Two-hybrid
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 2 2 2 Synthetic Lethality, Negative Genetic
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 2 2 2 Phenotypic Suppression, Negative Genetic
BUD6 YLR319C Actin- and formin-interacting protein genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
EXO70 YJL085W Subunit of the exocyst complex physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
PEA2 YER149C Coiled-coil 12S polarisome subunit genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
SLM4 YBR077C Subunit of the EGO/GSE complex genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
RHO4 YKR055W Non-essential small GTPase genetic 2 1 2 Dosage Rescue, Dosage Rescue
KIN1 YDR122W S/T protein kinase genetic 2 1 2 Dosage Rescue, Dosage Rescue
SEC10 YLR166C Essential 100kDa subunit of the exocyst complex genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
SEC5 YDR166C Essential 107kDa subunit of the exocyst complex genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
SEC8 YPR055W Essential 121 kDa subunit of the exocyst complex genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
MTC5 YDR128W Subunit of SEACAT, a subcomplex of the SEA complex genetic 2 1 2 Negative Genetic, Negative Genetic
RIM15 YFL033C Protein kinase involved in cell proliferation in response to nutrients genetic 2 1 2 Negative Genetic, Negative Genetic
GND2 YGR256W 6-phosphogluconate dehydrogenase (decarboxylating) genetic 2 1 2 Negative Genetic, Negative Genetic
DAN1 YJR150C Cell wall mannoprotein genetic 2 1 2 Negative Genetic, Negative Genetic
YPK2 YMR104C AGC-type S/T protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
YNL115C YNL115C Putative protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
LEU4 YNL104C Alpha-isopropylmalate synthase (2-isopropylmalate synthase) genetic 2 1 2 Negative Genetic, Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 2 1 2 Negative Genetic, Negative Genetic
OCA2 YNL056W Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
PBR1 YNL181W Putative oxidoreductase genetic 2 1 2 Negative Genetic, Negative Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 2 1 2 Negative Genetic, Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase genetic 2 1 2 Negative Genetic, Negative Genetic
BNI1 YNL271C Formin genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
AXL2 YIL140W Integral plasma membrane protein physical 2 2 1 Affinity Capture-Western, Reconstituted Complex
MSB1 YOR188W Protein of unknown function physical 2 2 1 Reconstituted Complex, Affinity Capture-Western
SKN7 YHR206W Nuclear response regulator and transcription factor genetic 2 2 1 Dosage Lethality, Synthetic Rescue
MSS4 YDR208W Phosphatidylinositol-4-phosphate 5-kinase genetic 2 2 1 Dosage Rescue, Synthetic Lethality
BUD3 YCL014W Guanine nucleotide exchange factor (GEF) for Cdc42p physical 2 2 1 Two-hybrid, Reconstituted Complex
BUD3 YCL014W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 2 2 1 Phenotypic Suppression, Dosage Rescue
MMS4 YBR098W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 2 1 1 Dosage Rescue, Dosage Rescue
SRV2 YNL138W CAP (cyclase-associated protein) genetic 2 1 1 Negative Genetic, Negative Genetic
PFY1 YOR122C Profilin genetic 2 1 1 Negative Genetic, Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 1 1 Negative Genetic, Negative Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
AIM25 YJR100C Mitochondria protein of unknown function genetic 1 1 1 Positive Genetic
SAN1 YDR143C Ubiquitin-protein ligase physical 1 1 1 Affinity Capture-MS
RDI1 YDL135C Rho GDP dissociation inhibitor genetic 1 1 1 Synthetic Growth Defect
RGA2 YDR379W GTPase-activating protein for polarity-establishment protein Cdc42p physical 1 1 1 Two-hybrid
LRG1 YDL240W GTPase-activating protein (GAP) physical 1 1 1 Two-hybrid
RGD2 YFL047W GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p physical 1 1 1 Two-hybrid
SKM1 YOL113W Member of the PAK family of serine/threonine protein kinases genetic 1 1 1 Synthetic Rescue
FAR1 YJL157C CDK inhibitor and nuclear anchor physical 1 1 1 Two-hybrid
MSB3 YNL293W Rab GTPase-activating protein physical 1 1 1 Reconstituted Complex
MSB4 YOL112W GTPase-activating protein of the Ras superfamily physical 1 1 1 Reconstituted Complex
MSB4 YOL112W GTPase-activating protein of the Ras superfamily genetic 1 1 1 Synthetic Lethality
STE50 YCL032W Adaptor protein for various signaling pathways physical 1 1 1 Affinity Capture-Western
SHE2 YKL130C RNA-binding protein that binds specific mRNAs and interacts with She3p physical 1 1 1 Affinity Capture-RNA
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 1 1 1 Affinity Capture-MS
KES1 YPL145C Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger physical 1 1 1 Affinity Capture-Western
MIC60 YKR016W Component of the MICOS complex physical 1 1 1 Affinity Capture-MS
FUS2 YMR232W Cell fusion regulator genetic 1 1 1 Phenotypic Enhancement
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SCP160 YJL080C Essential RNA-binding G protein effector of mating response pathway physical 1 1 1 Affinity Capture-RNA
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
SHO1 YER118C Transmembrane osmosensor for filamentous growth and HOG pathways physical 1 1 1 Affinity Capture-Western
SHO1 YER118C Transmembrane osmosensor for filamentous growth and HOG pathways genetic 1 1 1 Phenotypic Suppression
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
COX20 YDR231C Mitochondrial inner membrane protein physical 1 1 1 Affinity Capture-MS
KEL1 YHR158C Protein required for proper cell fusion and cell morphology physical 1 1 1 Affinity Capture-Western
KEL1 YHR158C Protein required for proper cell fusion and cell morphology genetic 1 1 1 Phenotypic Enhancement
SEC4 YFL005W Rab family GTPase physical 1 1 1 Co-fractionation
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
RCK2 YLR248W Protein kinase involved in response to oxidative and osmotic stress physical 1 1 1 Affinity Capture-MS
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
TOM22 YNL131W Component of the TOM (Translocase of Outer Membrane) complex physical 1 1 1 Affinity Capture-MS
TIM23 YNR017W Essential component of the TIM23 complex physical 1 1 1 Affinity Capture-MS
RAS2 YNL098C GTP-binding protein genetic 1 1 1 Dosage Rescue
SSO2 YMR183C Plasma membrane t-SNARE genetic 1 1 1 Dosage Rescue
SSK1 YLR006C Cytoplasmic phosphorelay intermediate osmosensor and regulator genetic 1 1 1 Synthetic Growth Defect
MBP1 YDL056W Transcription factor genetic 1 1 1 Synthetic Rescue
ZDS1 YMR273C Protein with a role in regulating Swe1p-dependent polarized growth genetic 1 1 1 Dosage Rescue
ZDS2 YML109W Protein with a role in regulating Swe1p-dependent polarized growth genetic 1 1 1 Dosage Rescue
PXL1 YKR090W Protein that localizes to sites of polarized growth genetic 1 1 1 Dosage Rescue
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Synthetic Growth Defect
KEX2 YNL238W Kexin, a subtilisin-like protease (proprotein convertase) genetic 1 1 1 Dosage Rescue
ENT1 YDL161W Epsin-like protein involved in endocytosis and actin patch assembly genetic 1 1 1 Phenotypic Suppression
SWH1 YAR042W Protein similar to mammalian oxysterol-binding protein genetic 1 1 1 Dosage Rescue
OSH2 YDL019C Member of an oxysterol-binding protein family with seven members genetic 1 1 1 Dosage Rescue
OSH6 YKR003W Oxysterol-binding phosphatidylserine transferase genetic 1 1 1 Dosage Rescue
OSH3 YHR073W Member of an oxysterol-binding protein family genetic 1 1 1 Dosage Rescue
KIN2 YLR096W S/T protein kinase genetic 1 1 1 Dosage Rescue
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Dosage Rescue
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 1 1 1 Synthetic Rescue
ZUO1 YGR285C Ribosome-associated chaperone genetic 1 1 1 Synthetic Rescue
SPO14 YKR031C Phospholipase D genetic 1 1 1 Phenotypic Suppression
GEM1 YAL048C Outer mitochondrial membrane GTPase, subunit of the ERMES complex genetic 1 1 1 Negative Genetic
FUI1 YBL042C High affinity uridine permease, localizes to the plasma membrane genetic 1 1 1 Negative Genetic
FIN1 YDR130C Spindle pole body-related intermediate filament protein genetic 1 1 1 Negative Genetic
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 1 1 1 Negative Genetic
NUM1 YDR150W Protein required for nuclear migration genetic 1 1 1 Negative Genetic
MDM35 YKL053C-A Mitochondrial intermembrane space protein genetic 1 1 1 Negative Genetic
ERG2 YMR202W C-8 sterol isomerase genetic 1 1 1 Negative Genetic
JNM1 YMR294W Component of the yeast dynactin complex genetic 1 1 1 Negative Genetic
MRS2 YOR334W Mitochondrial inner membrane Mg(2+) channel genetic 1 1 1 Negative Genetic
PMA2 YPL036W Plasma membrane H+-ATPase genetic 1 1 1 Negative Genetic
NAP1 YKR048C Histone chaperone and assembly chaperone for Rps6a/b genetic 1 1 1 Synthetic Rescue
HRT1 YOL133W RING-H2 domain core subunit of multiple ubiquitin ligase complexes genetic 1 1 1 Synthetic Growth Defect
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
RPM2 YML091C Protein subunit of mitochondrial RNase P genetic 1 1 1 Synthetic Growth Defect
DBP10 YDL031W Putative ATP-dependent RNA helicase of the DEAD-box protein family genetic 1 1 1 Synthetic Lethality
FAD1 YDL045C Flavin adenine dinucleotide (FAD) synthetase genetic 1 1 1 Synthetic Lethality
RPC40 YPR110C RNA polymerase subunit AC40 genetic 1 1 1 Synthetic Lethality
SIT4 YDL047W Ceramide-activated, type 2A-related serine-threonine phosphatase genetic 1 1 1 Synthetic Lethality
ROT1 YMR200W Molecular chaperone involved in protein folding in ER genetic 1 1 1 Dosage Rescue
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 1 1 1 Negative Genetic
ILM1 YJR118C Protein of unknown function genetic 1 1 1 Negative Genetic
MAE1 YKL029C Mitochondrial malic enzyme genetic 1 1 1 Negative Genetic
MDH1 YKL085W Mitochondrial malate dehydrogenase genetic 1 1 1 Negative Genetic
MBR1 YKL093W Protein involved in mitochondrial functions and stress response genetic 1 1 1 Negative Genetic
SDH1 YKL148C Flavoprotein subunit of succinate dehydrogenase genetic 1 1 1 Negative Genetic
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting genetic 1 1 1 Negative Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Negative Genetic
CSF1 YLR087C Protein with structural similarity to lipid transport protein Vps13p genetic 1 1 1 Negative Genetic
SEC72 YLR292C Non-essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 1 1 1 Negative Genetic
RCF1 YML030W Cytochrome c oxidase subunit genetic 1 1 1 Negative Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Negative Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
PGA3 YML125C Putative cytochrome b5 reductase, localized to the plasma membrane genetic 1 1 1 Negative Genetic
IDH1 YNL037C Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase genetic 1 1 1 Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
LEM3 YNL323W Membrane protein of the plasma membrane and ER genetic 1 1 1 Negative Genetic
CIT1 YNR001C Mitochondrial citrate synthase genetic 1 1 1 Negative Genetic
PFA4 YOL003C Palmitoyltransferase with autoacylation activity genetic 1 1 1 Negative Genetic
HTZ1 YOL012C Histone variant H2AZ genetic 1 1 1 Negative Genetic
TLG2 YOL018C Syntaxin-like t-SNARE genetic 1 1 1 Negative Genetic
VPS68 YOL129W Vacuolar membrane protein of unknown function genetic 1 1 1 Negative Genetic
GYP1 YOR070C Cis-golgi GTPase-activating protein (GAP) for yeast Rabs genetic 1 1 1 Negative Genetic
IDH2 YOR136W Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase genetic 1 1 1 Negative Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Negative Genetic
RUD3 YOR216C Golgi matrix protein genetic 1 1 1 Negative Genetic
SEC63 YOR254C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
VMA11 YPL234C Vacuolar ATPase V0 domain subunit c' genetic 1 1 1 Negative Genetic
SYT1 YPR095C Guanine nucleotide exchange factor (GEF) for Arf proteins genetic 1 1 1 Negative Genetic
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Synthetic Lethality
MAD1 YGL086W Coiled-coil protein involved in spindle-assembly checkpoint genetic 1 1 1 Synthetic Lethality
RAD51 YER095W Strand exchange protein genetic 1 1 1 Synthetic Lethality
TTI1 YKL033W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 1 1 1 Positive Genetic
SHG1 YBR258C Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Positive Genetic
FUN19 YAL034C Non-essential protein of unknown function genetic 1 1 1 Positive Genetic
LIH1 YJR107W Putative lipase genetic 1 1 1 Positive Genetic
CMD1 YBR109C Calmodulin genetic 1 1 1 Negative Genetic
QRI1 YDL103C UDP-N-acetylglucosamine pyrophosphorylase genetic 1 1 1 Negative Genetic
SEC1 YDR164C Sm-like protein involved in docking and fusion of exocytic vesicles genetic 1 1 1 Negative Genetic
NCB2 YDR397C Subunit of a heterodimeric NC2 transcription regulator complex genetic 1 1 1 Negative Genetic
WBP1 YEL002C Beta subunit of the oligosaccharyl transferase glycoprotein complex genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
SMC2 YFR031C Subunit of the condensin complex genetic 1 1 1 Negative Genetic
TAO3 YIL129C Component of the RAM signaling network genetic 1 1 1 Negative Genetic
PHS1 YJL097W Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane genetic 1 1 1 Negative Genetic
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 1 1 1 Negative Genetic
IPP1 YBR011C Cytoplasmic inorganic pyrophosphatase (PPase) genetic 1 1 1 Negative Genetic
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 1 1 1 Negative Genetic
TIM22 YDL217C Essential core component of mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex genetic 1 1 1 Negative Genetic
MES1 YGR264C Methionyl-tRNA synthetase genetic 1 1 1 Negative Genetic
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 1 1 1 Negative Genetic
INN1 YNL152W Essential protein that associates with contractile actomyosin ring genetic 1 1 1 Negative Genetic
MRS6 YOR370C Rab escort protein genetic 1 1 1 Negative Genetic
NIP7 YPL211W Nucleolar protein required for 60S ribosome subunit biogenesis genetic 1 1 1 Negative Genetic
RPL19B YBL027W Ribosomal 60S subunit protein L19B genetic 1 1 1 Negative Genetic
RPL13A YDL082W Ribosomal 60S subunit protein L13A genetic 1 1 1 Negative Genetic
CPR5 YDR304C Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the ER genetic 1 1 1 Negative Genetic
YGL242C YGL242C Protein of unknown function genetic 1 1 1 Negative Genetic
SLH1 YGR271W Subunit of ribosome-associated quality control trigger complex (RQT) genetic 1 1 1 Negative Genetic
FMO1 YHR176W Flavin-containing monooxygenase genetic 1 1 1 Negative Genetic
NVJ1 YHR195W Nuclear envelope protein genetic 1 1 1 Negative Genetic
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 1 1 1 Negative Genetic
PRM2 YIL037C Pheromone-regulated protein genetic 1 1 1 Negative Genetic
VPS35 YJL154C Endosomal subunit of membrane-associated retromer complex genetic 1 1 1 Negative Genetic
TDA4 YJR116W Protein distantly similar to ceramide synthases, Lag1p and Lac1p genetic 1 1 1 Negative Genetic
ENT3 YJR125C Protein containing an N-terminal epsin-like domain genetic 1 1 1 Negative Genetic
MNS1 YJR131W Alpha-1,2-mannosidase genetic 1 1 1 Negative Genetic
UBI4 YLL039C Ubiquitin genetic 1 1 1 Negative Genetic
UBR2 YLR024C Cytoplasmic ubiquitin-protein ligase (E3) genetic 1 1 1 Negative Genetic
PSP2 YML017W Asn rich cytoplasmic protein that contains RGG motifs genetic 1 1 1 Negative Genetic
MUB1 YMR100W MYND domain-containing protein genetic 1 1 1 Negative Genetic
LAP2 YNL045W Leucyl aminopeptidase yscIV with epoxide hydrolase activity genetic 1 1 1 Negative Genetic
EOS1 YNL080C Protein involved in N-glycosylation genetic 1 1 1 Negative Genetic
NCS2 YNL119W Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs genetic 1 1 1 Negative Genetic
HST1 YOL068C NAD(+)-dependent histone deacetylase genetic 1 1 1 Negative Genetic
ZEO1 YOL109W Peripheral membrane protein of the plasma membrane genetic 1 1 1 Negative Genetic
PTH4 YOL114C Protein similar to the human peptidyl-tRNA hydrolase gene ICT1 genetic 1 1 1 Negative Genetic
CHL1 YPL008W Probable DNA helicase genetic 1 1 1 Negative Genetic
YDL012C YDL012C Tail-anchored plasma membrane protein with a conserved CYSTM module genetic 1 1 1 Negative Genetic
SHS1 YDL225W Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
SWA2 YDR320C Auxilin-like protein involved in vesicular transport genetic 1 1 1 Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Negative Genetic
DNF1 YER166W Aminophospholipid translocase (flippase) genetic 1 1 1 Negative Genetic
ECM32 YER176W DNA dependent ATPase/DNA helicase genetic 1 1 1 Negative Genetic
CRH1 YGR189C Chitin transglycosylase genetic 1 1 1 Negative Genetic
YHL042W YHL042W Endoplasmic reticulum protein genetic 1 1 1 Negative Genetic
TUS1 YLR425W Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity genetic 1 1 1 Negative Genetic
VAN1 YML115C Component of the mannan polymerase I genetic 1 1 1 Negative Genetic
RIM13 YMR154C Calpain-like cysteine protease genetic 1 1 1 Negative Genetic
YOL097W-A YOL097W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
RRP6 YOR001W Nuclear exosome exonuclease component genetic 1 1 1 Negative Genetic
YOR011W-A YOR011W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YPR003C YPR003C Putative sulfate permease genetic 1 1 1 Negative Genetic
SUE1 YPR151C Protein required for degradation of unstable forms of cytochrome c genetic 1 1 1 Negative Genetic
RPL11B YGR085C Ribosomal 60S subunit protein L11B genetic 1 1 1 Positive Genetic
KSS1 YGR040W Mitogen-activated protein kinase (MAPK) genetic 1 1 1 Negative Genetic
NPR2 YEL062W Subunit of the Iml1p/SEACIT complex genetic 1 1 1 Negative Genetic
FAA1 YOR317W Long chain fatty acyl-CoA synthetase genetic 1 1 1 Positive Genetic
RAD52 YML032C Protein involved in homologous recombination genetic 1 1 1 Negative Genetic
RPS11B YBR048W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
IFM1 YOL023W Mitochondrial translation initiation factor 2 genetic 1 1 1 Positive Genetic
FMP52 YER004W Protein of unknown function genetic 1 1 1 Positive Genetic
CUL3 YGR003W Ubiquitin-protein ligase genetic 1 1 1 Negative Genetic
OST3 YOR085W Gamma subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Positive Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Positive Genetic
MEU1 YLR017W Methylthioadenosine phosphorylase (MTAP) genetic 1 1 1 Positive Genetic
SSK2 YNR031C MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway genetic 1 1 1 Positive Genetic
PPH22 YDL188C Catalytic subunit of protein phosphatase 2A, PP2A genetic 1 1 1 Positive Genetic
RPL11A YPR102C Ribosomal 60S subunit protein L11A genetic 1 1 1 Positive Genetic
RFC1 YOR217W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Positive Genetic
MGT1 YDL200C DNA repair methyltransferase (6-O-methylguanine-DNA methylase) genetic 1 1 1 Positive Genetic
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Positive Genetic
MSH1 YHR120W DNA-binding protein of the mitochondria genetic 1 1 1 Positive Genetic
RAD2 YGR258C Single-stranded DNA endonuclease genetic 1 1 1 Positive Genetic
YKL091C YKL091C Putative phosphatidylinositol/phosphatidylcholine transfer protein genetic 1 1 1 Positive Genetic
RAD23 YEL037C Protein with ubiquitin-like N terminus genetic 1 1 1 Positive Genetic
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 1 1 1 Positive Genetic
MSH3 YCR092C Mismatch repair protein genetic 1 1 1 Positive Genetic
MSH6 YDR097C Protein required for mismatch repair in mitosis and meiosis genetic 1 1 1 Positive Genetic
UFD2 YDL190C Ubiquitin (Ub) chain assembly factor (E4) genetic 1 1 1 Positive Genetic
HNT2 YDR305C Dinucleoside triphosphate hydrolase genetic 1 1 1 Positive Genetic
DAP2 YHR028C Dipeptidyl aminopeptidase genetic 1 1 1 Positive Genetic
LIF1 YGL090W Component of the DNA ligase IV complex genetic 1 1 1 Positive Genetic
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation genetic 1 1 1 Positive Genetic
SDH2 YLL041C Iron-sulfur protein subunit of succinate dehydrogenase genetic 1 1 1 Positive Genetic
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 1 1 1 Negative Genetic
STH1 YIL126W ATPase component of the RSC chromatin remodeling complex genetic 1 1 1 Positive Genetic
FAA2 YER015W Medium chain fatty acyl-CoA synthetase genetic 1 1 1 Positive Genetic
SSL2 YIL143C Component of RNA polymerase transcription factor TFIIH holoenzyme genetic 1 1 1 Positive Genetic
IRA1 YBR140C GTPase-activating protein genetic 1 1 1 Positive Genetic
CRS1 YNL247W Cysteinyl-tRNA synthetase genetic 1 1 1 Positive Genetic
RPS10B YMR230W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
PMS1 YNL082W ATP-binding protein required for mismatch repair genetic 1 1 1 Positive Genetic
REB1 YBR049C RNA polymerase I enhancer binding protein genetic 1 1 1 Positive Genetic
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 1 1 1 Positive Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Positive Genetic
DST1 YGL043W General transcription elongation factor TFIIS genetic 1 1 1 Positive Genetic
TFB3 YDR460W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Positive Genetic
SAS3 YBL052C Histone acetyltransferase catalytic subunit of NuA3 complex genetic 1 1 1 Positive Genetic
RAD24 YER173W Checkpoint protein genetic 1 1 1 Positive Genetic
FPK1 YNR047W Ser/Thr protein kinase genetic 1 1 1 Synthetic Rescue
MID2 YLR332W O-glycosylated plasma membrane protein genetic 1 1 1 Synthetic Rescue
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 1 1 1 Phenotypic Suppression
BMH1 YER177W 14-3-3 protein, major isoform genetic 1 1 1 Synthetic Growth Defect
BUD20 YLR074C C2H2-type zinc finger protein required for ribosome assembly genetic 1 1 1 Negative Genetic
CDC10 YCR002C Component of the septin ring, required for cytokinesis physical 1 1 1 Co-localization
BGL2 YGR282C Endo-beta-1,3-glucanase genetic 1 1 1 Negative Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 1 1 1 Negative Genetic
BOI1 YBL085W Protein involved in polar growth, functionally redundant with Boi2p genetic 1 1 1 Dosage Rescue
ACO1 YLR304C Aconitase genetic 1 1 1 Negative Genetic
ADH2 YMR303C Glucose-repressible alcohol dehydrogenase II physical 1 1 1 Affinity Capture-MS
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-MS
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
BUB2 YMR055C Mitotic exit network regulator genetic 1 1 1 Synthetic Rescue
BFA1 YJR053W Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p genetic 1 1 1 Positive Genetic
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 1 1 1 Positive Genetic
BEM3 YPL115C Rho GTPase activating protein (RhoGAP) genetic 1 1 1 Dosage Rescue
ARA1 YBR149W NADP+ dependent arabinose dehydrogenase genetic 1 1 1 Negative Genetic
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 1 1 1 Positive Genetic
APC11 YDL008W Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Synthetic Lethality
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex genetic 1 1 1 Negative Genetic
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 1 1 1 Synthetic Lethality
AKR1 YDR264C Palmitoyl transferase involved in protein palmitoylation genetic 1 1 1 Phenotypic Suppression
BCH2 YKR027W Member of the ChAPs (Chs5p-Arf1p-binding proteins) family genetic 1 1 1 Negative Genetic
BYE1 YKL005C Negative regulator of transcription elongation genetic 1 1 1 Negative Genetic
ALG9 YNL219C Mannosyltransferase, involved in N-linked glycosylation genetic 1 1 1 Negative Genetic
BUD16 YEL029C Putative pyridoxal kinase genetic 1 1 1 Negative Genetic