BOI1 |
YBL085W |
Protein involved in polar growth, functionally redundant with Boi2p |
genetic |
11 |
4 |
10 |
Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement |
BEM1 |
YBR200W |
Protein containing SH3-domains |
physical |
9 |
4 |
8 |
Affinity Capture-MS, Two-hybrid, Two-hybrid, Reconstituted Complex, Two-hybrid, Affinity Capture-MS, Two-hybrid, Protein-peptide, Two-hybrid |
CDC24 |
YAL041W |
Guanine nucleotide exchange factor (GEF) for Cdc42p |
physical |
6 |
3 |
5 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Two-hybrid, Two-hybrid |
JNM1 |
YMR294W |
Component of the yeast dynactin complex |
genetic |
6 |
3 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
CDC42 |
YLR229C |
Small rho-like GTPase |
physical |
5 |
3 |
3 |
Two-hybrid, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western |
DYN1 |
YKR054C |
Cytoplasmic heavy chain dynein |
genetic |
5 |
2 |
3 |
Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
NIP100 |
YPL174C |
Large subunit of the dynactin complex |
genetic |
5 |
2 |
3 |
Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
ARP1 |
YHR129C |
Actin-related protein of the dynactin complex |
genetic |
5 |
2 |
3 |
Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
LDB18 |
YLL049W |
Component of the dynactin complex |
genetic |
5 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
PAC1 |
YOR269W |
Regulator of dynein, involved in intracellular transport |
genetic |
5 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
SEC1 |
YDR164C |
Sm-like protein involved in docking and fusion of exocytic vesicles |
physical |
5 |
4 |
2 |
PCA, Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Reconstituted Complex |
EXO70 |
YJL085W |
Subunit of the exocyst complex |
genetic |
4 |
3 |
3 |
Negative Genetic, Negative Genetic, Dosage Rescue, Phenotypic Suppression |
PAC11 |
YDR488C |
Dynein intermediate chain, microtubule motor protein |
genetic |
4 |
2 |
3 |
Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
NUM1 |
YDR150W |
Protein required for nuclear migration |
genetic |
4 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
DYN3 |
YMR299C |
Dynein light intermediate chain (LIC) |
genetic |
4 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
EPO1 |
YMR124W |
Protein involved in septin-ER tethering |
physical |
3 |
2 |
3 |
Two-hybrid, PCA, Two-hybrid |
SEC15 |
YGL233W |
Essential 113 kDa subunit of the exocyst complex |
genetic |
3 |
2 |
3 |
Negative Genetic, Negative Genetic, Dosage Rescue |
RHO3 |
YIL118W |
Non-essential small GTPase of the Rho/Rac family of Ras-like proteins |
genetic |
3 |
2 |
3 |
Dosage Rescue, Dosage Rescue, Phenotypic Suppression |
DSE1 |
YER124C |
Daughter cell-specific protein |
physical |
3 |
1 |
3 |
Two-hybrid, Two-hybrid, Two-hybrid |
BIT2 |
YBR270C |
Subunit of TORC2 membrane-associated complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
MSB1 |
YOR188W |
Protein of unknown function |
physical |
2 |
2 |
2 |
Two-hybrid, Affinity Capture-Western |
NAM7 |
YMR080C |
ATP-dependent RNA helicase of the SFI superfamily |
physical |
2 |
2 |
2 |
Two-hybrid, Affinity Capture-RNA |
SEC1 |
YDR164C |
Sm-like protein involved in docking and fusion of exocytic vesicles |
genetic |
2 |
2 |
2 |
Negative Genetic, Dosage Rescue |
BUD6 |
YLR319C |
Actin- and formin-interacting protein |
physical |
2 |
2 |
2 |
Two-hybrid, PCA |
BOI2 |
YER114C |
Protein involved in polar growth |
physical |
2 |
2 |
2 |
Two-hybrid, Reconstituted Complex |
BMH1 |
YER177W |
14-3-3 protein, major isoform |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
ZDS2 |
YML109W |
Protein with a role in regulating Swe1p-dependent polarized growth |
physical |
2 |
1 |
2 |
Two-hybrid, Two-hybrid |
MPT5 |
YGL178W |
mRNA-binding protein of the PUF family |
physical |
2 |
1 |
2 |
Affinity Capture-RNA, Affinity Capture-RNA |
RHO4 |
YKR055W |
Non-essential small GTPase |
genetic |
2 |
1 |
2 |
Dosage Rescue, Dosage Rescue |
ELM1 |
YKL048C |
Serine/threonine protein kinase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MPO1 |
YGL010W |
Dioxygenase that catalyzes alpha-oxygenation of 2-hydroxy fatty acids |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RCI50 |
YKL133C |
Mitochondrial protein of unknown function |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SWI6 |
YLR182W |
Transcription cofactor |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
DBP1 |
YPL119C |
ATP-dependent RNA helicase of the DEAD-box protein family |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CNA1 |
YLR433C |
Calcineurin A |
physical |
2 |
2 |
1 |
Reconstituted Complex, Biochemical Activity |
RHO3 |
YIL118W |
Non-essential small GTPase of the Rho/Rac family of Ras-like proteins |
physical |
2 |
2 |
1 |
Reconstituted Complex, Affinity Capture-Western |
BOI1 |
YBL085W |
Protein involved in polar growth, functionally redundant with Boi2p |
physical |
2 |
2 |
1 |
PCA, Two-hybrid |
STE20 |
YHL007C |
Cdc42p-activated signal transducing kinase |
physical |
2 |
1 |
1 |
Two-hybrid, Two-hybrid |
GLC7 |
YER133W |
Type 1 S/T protein phosphatase (PP1) catalytic subunit |
genetic |
2 |
1 |
1 |
Synthetic Lethality, Synthetic Lethality |
RPP2B |
YDR382W |
Ribosomal protein P2 beta |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
UBA3 |
YPR066W |
Protein that activates Rub1p (NEDD8) before neddylation |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
APC9 |
YLR102C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
CBF1 |
YJR060W |
Basic helix-loop-helix (bHLH) protein |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
TYE7 |
YOR344C |
Serine-rich protein that contains a bHLH DNA binding motif |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
regulation |
1 |
1 |
1 |
quantitative mass spectrometry evidence |
CLA4 |
YNL298W |
Cdc42p-activated signal transducing kinase |
physical |
1 |
1 |
1 |
Two-hybrid |
MRS6 |
YOR370C |
Rab escort protein |
physical |
1 |
1 |
1 |
Two-hybrid |
MSB1 |
YOR188W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SHO1 |
YER118C |
Transmembrane osmosensor for filamentous growth and HOG pathways |
physical |
1 |
1 |
1 |
Two-hybrid |
FIR1 |
YER032W |
Protein involved in 3' mRNA processing |
physical |
1 |
1 |
1 |
Two-hybrid |
IML1 |
YJR138W |
GTPase-activating protein (GAP) subunit of the Iml1p/SEACIT complex |
physical |
1 |
1 |
1 |
Two-hybrid |
NIS1 |
YNL078W |
Protein involved in axial bud site selection |
physical |
1 |
1 |
1 |
Two-hybrid |
NDC80 |
YIL144W |
Component of the kinetochore-associated Ndc80 complex |
physical |
1 |
1 |
1 |
Two-hybrid |
YER158C |
YER158C |
Protein of unknown function |
physical |
1 |
1 |
1 |
Two-hybrid |
YMR244W |
YMR244W |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Two-hybrid |
CDC55 |
YGL190C |
Regulatory subunit B of protein phosphatase 2A (PP2A) |
physical |
1 |
1 |
1 |
Two-hybrid |
CDC55 |
YGL190C |
Regulatory subunit B of protein phosphatase 2A (PP2A) |
genetic |
1 |
1 |
1 |
Negative Genetic |
DIG1 |
YPL049C |
MAP kinase-responsive inhibitor of the Ste12p transcription factor |
physical |
1 |
1 |
1 |
Two-hybrid |
DIG2 |
YDR480W |
MAP kinase-responsive inhibitor of the Ste12p transcription factor |
physical |
1 |
1 |
1 |
Two-hybrid |
MET31 |
YPL038W |
Zinc-finger DNA-binding transcription factor |
physical |
1 |
1 |
1 |
Two-hybrid |
YAP6 |
YDR259C |
Basic leucine zipper (bZIP) transcription factor |
physical |
1 |
1 |
1 |
Two-hybrid |
FUS3 |
YBL016W |
Mitogen-activated serine/threonine protein kinase involved in mating |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NBP2 |
YDR162C |
Protein involved in the HOG (high osmolarity glycerol) pathway |
physical |
1 |
1 |
1 |
Protein-peptide |
NBP2 |
YDR162C |
Protein involved in the HOG (high osmolarity glycerol) pathway |
genetic |
1 |
1 |
1 |
Negative Genetic |
HHF1 |
YBR009C |
Histone H4 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HHF2 |
YNL030W |
Histone H4 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HHT1 |
YBR010W |
Histone H3 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HHT2 |
YNL031C |
Histone H3 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CMR1 |
YDL156W |
Nuclear protein with role in transcription, protein quality control |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
physical |
1 |
1 |
1 |
Biochemical Activity |
CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
1 |
1 |
1 |
Dosage Lethality |
SSB2 |
YNL209W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
1 |
1 |
1 |
Co-purification |
CRM1 |
YGR218W |
Nuclear export factor, exportin |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SPT16 |
YGL207W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPB3 |
YIL021W |
RNA polymerase II third largest subunit B44 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TMA46 |
YOR091W |
Protein of unknown function that associates with translating ribosomes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
HOG1 |
YLR113W |
Mitogen-activated protein kinase involved in osmoregulation |
physical |
1 |
1 |
1 |
Co-localization |
DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
VTS1 |
YOR359W |
Flap-structured DNA-binding and RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
FKS1 |
YLR342W |
Catalytic subunit of 1,3-beta-D-glucan synthase |
physical |
1 |
1 |
1 |
Two-hybrid |
TPK1 |
YJL164C |
cAMP-dependent protein kinase catalytic subunit |
physical |
1 |
1 |
1 |
Two-hybrid |
CBK1 |
YNL161W |
Serine/threonine protein kinase of the the RAM signaling network |
physical |
1 |
1 |
1 |
Two-hybrid |
RGA2 |
YDR379W |
GTPase-activating protein for polarity-establishment protein Cdc42p |
physical |
1 |
1 |
1 |
Two-hybrid |
RSR1 |
YGR152C |
Ras-type GTPase |
physical |
1 |
1 |
1 |
Two-hybrid |
RSR1 |
YGR152C |
Ras-type GTPase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SEC4 |
YFL005W |
Rab family GTPase |
physical |
1 |
1 |
1 |
Two-hybrid |
NBA1 |
YOL070C |
Protein involved in axial bud site selection |
physical |
1 |
1 |
1 |
Two-hybrid |
PAR32 |
YDL173W |
Low complexity protein |
physical |
1 |
1 |
1 |
Two-hybrid |
RAS1 |
YOR101W |
GTPase involved in G-protein signaling in adenylate cyclase activation |
physical |
1 |
1 |
1 |
Two-hybrid |
RHO4 |
YKR055W |
Non-essential small GTPase |
physical |
1 |
1 |
1 |
Two-hybrid |
EXO84 |
YBR102C |
Exocyst subunit with dual roles in exocytosis and spliceosome assembly |
physical |
1 |
1 |
1 |
PCA |
EXO84 |
YBR102C |
Exocyst subunit with dual roles in exocytosis and spliceosome assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
SEC3 |
YER008C |
Subunit of the exocyst complex |
physical |
1 |
1 |
1 |
PCA |
SEC5 |
YDR166C |
Essential 107kDa subunit of the exocyst complex |
physical |
1 |
1 |
1 |
PCA |
SEC6 |
YIL068C |
Essential 88kDa subunit of the exocyst complex |
physical |
1 |
1 |
1 |
PCA |
SEC8 |
YPR055W |
Essential 121 kDa subunit of the exocyst complex |
physical |
1 |
1 |
1 |
PCA |
SEC8 |
YPR055W |
Essential 121 kDa subunit of the exocyst complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SEC15 |
YGL233W |
Essential 113 kDa subunit of the exocyst complex |
physical |
1 |
1 |
1 |
PCA |
EXO70 |
YJL085W |
Subunit of the exocyst complex |
physical |
1 |
1 |
1 |
PCA |
CDC5 |
YMR001C |
Polo-like kinase required for mitotic exit |
physical |
1 |
1 |
1 |
Proximity Label-MS |
MSS4 |
YDR208W |
Phosphatidylinositol-4-phosphate 5-kinase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
YKU70 |
YMR284W |
Subunit of the telomeric Ku complex (Yku70p-Yku80p) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MRE11 |
YMR224C |
Nuclease subunit of the MRX complex with Rad50p and Xrs2p |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RAM1 |
YDL090C |
Beta subunit of the CAAX farnesyltransferase (FTase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
PTC1 |
YDL006W |
Type 2C protein phosphatase (PP2C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
PTC2 |
YER089C |
Type 2C protein phosphatase (PP2C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
UBP3 |
YER151C |
Ubiquitin-specific protease that cleaves Ub-protein fusions |
genetic |
1 |
1 |
1 |
Negative Genetic |
PLC1 |
YPL268W |
Phospholipase C |
genetic |
1 |
1 |
1 |
Negative Genetic |
MOD5 |
YOR274W |
Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
DDI1 |
YER143W |
Aspartic-type endopeptidase |
genetic |
1 |
1 |
1 |
Negative Genetic |
NPL3 |
YDR432W |
RNA-binding protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
VHT1 |
YGR065C |
High-affinity plasma membrane H+-biotin (vitamin H) symporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
CCT8 |
YJL008C |
Subunit of the cytosolic chaperonin Cct ring complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SEC10 |
YLR166C |
Essential 100kDa subunit of the exocyst complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SEC2 |
YNL272C |
Guanyl-nucleotide exchange factor for the small G-protein Sec4p |
genetic |
1 |
1 |
1 |
Negative Genetic |
DRS2 |
YAL026C |
Trans-golgi network aminophospholipid translocase (flippase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
NPL4 |
YBR170C |
Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase |
genetic |
1 |
1 |
1 |
Negative Genetic |
NNK1 |
YKL171W |
Protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
PSR1 |
YLL010C |
Plasma membrane-associated protein phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPL1B |
YGL135W |
Ribosomal 60S subunit protein L1B |
genetic |
1 |
1 |
1 |
Negative Genetic |
YGR016W |
YGR016W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
VPS62 |
YGR141W |
Vacuolar protein sorting (VPS) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
YLR159W |
YLR159W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
ROM2 |
YLR371W |
Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
YML100W-A |
YML100W-A |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
MME1 |
YMR166C |
Transporter of the mitochondrial inner membrane that exports magnesium |
genetic |
1 |
1 |
1 |
Negative Genetic |
YOR012W |
YOR012W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
FIN1 |
YDR130C |
Spindle pole body-related intermediate filament protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
YOR268C |
YOR268C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
SSO1 |
YPL232W |
Plasma membrane t-SNARE |
genetic |
1 |
1 |
1 |
Dosage Rescue |
DSE3 |
YOR264W |
Daughter cell-specific protein, may help establish daughter fate |
genetic |
1 |
1 |
1 |
Positive Genetic |
KRE5 |
YOR336W |
Protein required for beta-1,6 glucan biosynthesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
TOP2 |
YNL088W |
Topoisomerase II |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
BUB2 |
YMR055C |
Mitotic exit network regulator |
genetic |
1 |
1 |
1 |
Negative Genetic |
RGA1 |
YOR127W |
GTPase-activating protein for polarity-regulator Cdc42p (RhoGAP) |
genetic |
1 |
1 |
1 |
Dosage Rescue |
BNI1 |
YNL271C |
Formin |
physical |
1 |
1 |
1 |
PCA |
APP1 |
YNL094W |
Phosphatidate phosphatase, converts phosphatidate to diacylglycerol |
genetic |
1 |
1 |
1 |
Negative Genetic |
AFR1 |
YDR085C |
Protein required for pheromone-induced projection (shmoo) formation |
physical |
1 |
1 |
1 |
Two-hybrid |
AIM44 |
YPL158C |
Regulator of Cdc42p and Rho1p |
physical |
1 |
1 |
1 |
Two-hybrid |
ASI2 |
YNL159C |
Subunit of the inner nuclear membrane Asi ubiquitin ligase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
ALP1 |
YNL270C |
Arginine transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |