GEnome-wide tool for Multi-scale Modeling
data Extraction and Representation
for Saccharomyces cerevisiae

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.

Standard name	Systematic name	Name description	Type	#Experiments	#Methods	#Publications	Evidence
SEC8	YPR055W	Essential 121 kDa subunit of the exocyst complex	physical	16	5	13	Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-Western, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-localization, Co-localization, Affinity Capture-Western, Reconstituted Complex
SEC5	YDR166C	Essential 107kDa subunit of the exocyst complex	physical	11	6	8	Reconstituted Complex, Affinity Capture-MS, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, PCA, Affinity Capture-Western, Co-localization, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex
EXO84	YBR102C	Exocyst subunit with dual roles in exocytosis and spliceosome assembly	physical	9	4	7	Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-localization, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex
SEC10	YLR166C	Essential 100kDa subunit of the exocyst complex	physical	8	4	7	Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Co-localization
SEC15	YGL233W	Essential 113 kDa subunit of the exocyst complex	physical	8	4	7	Co-fractionation, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-localization
SEC4	YFL005W	Rab family GTPase	genetic	7	3	5	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Dosage Rescue
SEC3	YER008C	Subunit of the exocyst complex	physical	7	3	4	Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-localization, Co-localization, Affinity Capture-Western, Affinity Capture-MS
EXO70	YJL085W	Subunit of the exocyst complex	physical	6	3	6	Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex
SEC1	YDR164C	Sm-like protein involved in docking and fusion of exocytic vesicles	genetic	6	4	4	Phenotypic Suppression, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Dosage Rescue
SEC10	YLR166C	Essential 100kDa subunit of the exocyst complex	genetic	6	3	4	Dosage Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
SEC5	YDR166C	Essential 107kDa subunit of the exocyst complex	genetic	6	3	4	Phenotypic Suppression, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
SEC8	YPR055W	Essential 121 kDa subunit of the exocyst complex	genetic	6	2	4	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
EXO70	YJL085W	Subunit of the exocyst complex	genetic	5	3	4	Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect
SEC9	YGR009C	t-SNARE protein required for secretory vesicle-plasma membrane fusion	physical	5	3	3	Affinity Capture-Western, Co-purification, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex
SEC9	YGR009C	t-SNARE protein required for secretory vesicle-plasma membrane fusion	genetic	5	3	3	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Synthetic Growth Defect
SEC1	YDR164C	Sm-like protein involved in docking and fusion of exocytic vesicles	physical	4	4	1	Reconstituted Complex, Co-fractionation, Co-purification, Affinity Capture-Western
SEC6	YIL068C	Essential 88kDa subunit of the exocyst complex	physical	3	3	3	Co-purification, PCA, Reconstituted Complex
SEC3	YER008C	Subunit of the exocyst complex	genetic	3	2	3	Synthetic Lethality, Synthetic Lethality, Negative Genetic
SEC15	YGL233W	Essential 113 kDa subunit of the exocyst complex	genetic	3	1	2	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
SEC2	YNL272C	Guanyl-nucleotide exchange factor for the small G-protein Sec4p	genetic	3	1	2	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
SNC2	YOR327C	Vesicle membrane receptor protein (v-SNARE)	genetic	2	2	2	Dosage Rescue, Negative Genetic
SGS1	YMR190C	RecQ family nucleolar DNA helicase	genetic	2	2	2	Phenotypic Enhancement, Negative Genetic
MSO1	YNR049C	Lipid-interacting protein in SNARE complex assembly machinery	genetic	2	2	2	Synthetic Lethality, Negative Genetic
SAC1	YKL212W	Phosphatidylinositol phosphate phosphatase	genetic	2	2	2	Synthetic Rescue, Negative Genetic
VPS1	YKR001C	Dynamin-like GTPase required for vacuolar sorting	genetic	2	1	2	Phenotypic Enhancement, Phenotypic Enhancement
TPM1	YNL079C	Major isoform of tropomyosin	genetic	2	1	2	Phenotypic Suppression, Phenotypic Suppression
PMR1	YGL167C	High affinity Ca2+/Mn2+ P-type ATPase	genetic	2	2	1	Phenotypic Suppression, Dosage Lethality
KES1	YPL145C	Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger	physical	2	1	1	Affinity Capture-Western, Affinity Capture-Western
EXO84	YBR102C	Exocyst subunit with dual roles in exocytosis and spliceosome assembly	genetic	2	1	1	Negative Genetic, Negative Genetic
FHL1	YPR104C	Regulator of ribosomal protein (RP) transcription	regulation	1	1	1	chromatin immunoprecipitation-chip evidence
PSF1	YDR013W	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p)	genetic	1	1	1	Positive Genetic
NIP7	YPL211W	Nucleolar protein required for 60S ribosome subunit biogenesis	genetic	1	1	1	Negative Genetic
PEX7	YDR142C	Peroxisomal signal receptor for peroxisomal matrix proteins	physical	1	1	1	Affinity Capture-MS
PEX7	YDR142C	Peroxisomal signal receptor for peroxisomal matrix proteins	genetic	1	1	1	Negative Genetic
KAP123	YER110C	Karyopherin beta	genetic	1	1	1	Negative Genetic
PRP45	YAL032C	Protein required for pre-mRNA splicing	physical	1	1	1	Two-hybrid
PAT1	YCR077C	Deadenylation-dependent mRNA-decapping factor	genetic	1	1	1	Phenotypic Suppression
RPN5	YDL147W	Subunit of the CSN and 26S proteasome lid complexes	genetic	1	1	1	Negative Genetic
ACT1	YFL039C	Actin, structural protein in cytoskeleton	genetic	1	1	1	Negative Genetic
CCR4	YAL021C	Component of the CCR4-NOT transcriptional complex	physical	1	1	1	Affinity Capture-RNA
NAB2	YGL122C	Nuclear polyadenylated RNA-binding protein	physical	1	1	1	Affinity Capture-RNA
BEM1	YBR200W	Protein containing SH3-domains	physical	1	1	1	Co-purification
BOI2	YER114C	Protein involved in polar growth	physical	1	1	1	PCA
CDC28	YBR160W	Cyclin-dependent kinase (CDK) catalytic subunit	genetic	1	1	1	Phenotypic Suppression
AVO1	YOL078W	Component of the membrane-bound TORC2 complex	genetic	1	1	1	Negative Genetic
CHC1	YGL206C	Clathrin heavy chain	genetic	1	1	1	Phenotypic Enhancement
COX5A	YNL052W	Subunit Va of cytochrome c oxidase	genetic	1	1	1	Negative Genetic
GDI1	YER136W	GDP dissociation inhibitor	genetic	1	1	1	Synthetic Lethality
DHH1	YDL160C	Cytoplasmic DEAD-box helicase and mRNA decapping activator	physical	1	1	1	Affinity Capture-RNA
HRP1	YOL123W	Subunit of cleavage factor I	genetic	1	1	1	Negative Genetic
ISW1	YBR245C	ATPase subunit of imitation-switch (ISWI) class chromatin remodelers	physical	1	1	1	Affinity Capture-RNA
MYO2	YOR326W	Type V myosin motor involved in actin-based transport of cargos	physical	1	1	1	Affinity Capture-Western
APM1	YPL259C	Mu1-like medium subunit of the AP-1 complex	genetic	1	1	1	Phenotypic Enhancement
DOA4	YDR069C	Ubiquitin hydrolase	genetic	1	1	1	Negative Genetic
IWR1	YDL115C	RNA polymerase II transport factor, conserved from yeast to humans	genetic	1	1	1	Negative Genetic
SEC27	YGL137W	Essential beta'-coat protein of the COPI coatomer	genetic	1	1	1	Negative Genetic
SEC23	YPR181C	GTPase-activating protein, stimulates the GTPase activity of Sar1p	genetic	1	1	1	Negative Genetic
BZZ1	YHR114W	SH3 domain protein implicated in regulating actin polymerization	genetic	1	1	1	Negative Genetic
RAD1	YPL022W	Single-stranded DNA endonuclease (with Rad10p)	physical	1	1	1	Affinity Capture-MS
BOI1	YBL085W	Protein involved in polar growth, functionally redundant with Boi2p	physical	1	1	1	PCA
PUF3	YLL013C	Protein of the mitochondrial outer surface	physical	1	1	1	Affinity Capture-RNA
RNA1	YMR235C	GTPase activating protein (GAP) for Gsp1p	genetic	1	1	1	Negative Genetic
RVS167	YDR388W	Calmodulin-binding actin-associated protein	genetic	1	1	1	Synthetic Growth Defect
BOP2	YLR267W	Protein of unknown function	genetic	1	1	1	Negative Genetic
IRE1	YHR079C	Serine-threonine kinase and endoribonuclease	genetic	1	1	1	Synthetic Growth Defect
PKC1	YBL105C	Protein serine/threonine kinase	genetic	1	1	1	Phenotypic Suppression
GPN2	YOR262W	Putative GTPase with a specific role in RNA pol II and polIII biogenes	genetic	1	1	1	Negative Genetic
ASK10	YGR097W	Regulator of the Fps1p glycerol channel	genetic	1	1	1	Negative Genetic
PEP12	YOR036W	Target membrane receptor (t-SNARE)	genetic	1	1	1	Phenotypic Enhancement
RAD9	YDR217C	DNA damage-dependent checkpoint protein	genetic	1	1	1	Phenotypic Enhancement
ELO2	YCR034W	Fatty acid elongase, involved in sphingolipid biosynthesis	genetic	1	1	1	Negative Genetic
EXO1	YOR033C	5'-3' exonuclease and flap-endonuclease	physical	1	1	1	Affinity Capture-MS
SBH1	YER087C-B	Beta subunit of Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p)	genetic	1	1	1	Dosage Rescue
SYF1	YDR416W	Member of the NineTeen Complex (NTC)	physical	1	1	1	Affinity Capture-MS
SNT1	YCR033W	Set3C histone deacetylase scaffold	physical	1	1	1	PCA
STE2	YFL026W	Receptor for alpha-factor pheromone	physical	1	1	1	PCA
SNC2	YOR327C	Vesicle membrane receptor protein (v-SNARE)	physical	1	1	1	Reconstituted Complex
SSO2	YMR183C	Plasma membrane t-SNARE	physical	1	1	1	Reconstituted Complex
SLT2	YHR030C	Serine/threonine MAP kinase	physical	1	1	1	PCA
SEC61	YLR378C	Conserved ER protein translocation channel	genetic	1	1	1	Dosage Rescue
VPS4	YPR173C	AAA-ATPase involved in multivesicular body (MVB) protein sorting	genetic	1	1	1	Phenotypic Enhancement
YPT1	YFL038C	Rab family GTPase	genetic	1	1	1	Synthetic Lethality
SSO1	YPL232W	Plasma membrane t-SNARE	genetic	1	1	1	Dosage Rescue
TPM2	YIL138C	Minor isoform of tropomyosin	genetic	1	1	1	Phenotypic Suppression
SWE1	YJL187C	Protein kinase that regulates the G2/M transition	genetic	1	1	1	Phenotypic Suppression
ZDS1	YMR273C	Protein with a role in regulating Swe1p-dependent polarized growth	genetic	1	1	1	Phenotypic Suppression
TTI1	YKL033W	Subunit of the ASTRA complex, involved in chromatin remodeling	genetic	1	1	1	Negative Genetic
YCK2	YNL154C	Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform	genetic	1	1	1	Synthetic Growth Defect
VMA8	YEL051W	Subunit D of the V1 peripheral membrane domain of V-ATPase	genetic	1	1	1	Positive Genetic
USE1	YGL098W	Essential SNARE protein localized to the ER	genetic	1	1	1	Negative Genetic
TIM22	YDL217C	Essential core component of mitochondrial TIM22 complex	genetic	1	1	1	Negative Genetic
SRV2	YNL138W	CAP (cyclase-associated protein)	genetic	1	1	1	Negative Genetic
TPS1	YBR126C	Synthase subunit of trehalose-6-P synthase/phosphatase complex	genetic	1	1	1	Negative Genetic
THR4	YCR053W	Threonine synthase	genetic	1	1	1	Negative Genetic
SLM3	YDL033C	tRNA-specific 2-thiouridylase	genetic	1	1	1	Negative Genetic
UGX2	YDL169C	Protein of unknown function	genetic	1	1	1	Negative Genetic
SWF1	YDR126W	Palmitoyltransferase that acts on transmembrane proteins	genetic	1	1	1	Negative Genetic
SRB2	YHR041C	Subunit of the RNA polymerase II mediator complex	genetic	1	1	1	Negative Genetic
SIN3	YOL004W	Component of both the Rpd3S and Rpd3L histone deacetylase complexes	genetic	1	1	1	Negative Genetic
SFL1	YOR140W	Transcriptional repressor and activator	genetic	1	1	1	Negative Genetic
YME1	YPR024W	Catalytic subunit of i-AAA protease complex	genetic	1	1	1	Negative Genetic
YBR238C	YBR238C	Mitochondrial membrane protein	genetic	1	1	1	Negative Genetic
SSD1	YDR293C	Translational repressor	genetic	1	1	1	Negative Genetic
SNF2	YOR290C	Catalytic subunit of the SWI/SNF chromatin remodeling complex	genetic	1	1	1	Negative Genetic
YKU80	YMR106C	Subunit of telomeric Ku complex (Yku70p-Yku80p)	genetic	1	1	1	Phenotypic Enhancement
SEC22	YLR268W	R-SNARE protein	physical	1	1	1	Reconstituted Complex
MSO1	YNR049C	Lipid-interacting protein in SNARE complex assembly machinery	physical	1	1	1	PCA
PET494	YNR045W	Mitochondrial translational activator specific for the COX3 mRNA	genetic	1	1	1	Negative Genetic
GPR1	YDL035C	Plasma membrane G protein coupled receptor (GPCR)	genetic	1	1	1	Negative Genetic
RTN1	YDR233C	Reticulon protein	physical	1	1	1	Affinity Capture-Western
RTN1	YDR233C	Reticulon protein	genetic	1	1	1	Dosage Growth Defect
ESBP6	YNL125C	Protein with similarity to monocarboxylate permeases	genetic	1	1	1	Negative Genetic
PHO11	YAR071W	One of three repressible acid phosphatases	genetic	1	1	1	Negative Genetic
MSS4	YDR208W	Phosphatidylinositol-4-phosphate 5-kinase	genetic	1	1	1	Dosage Rescue
AIM22	YJL046W	Lipoate-protein ligase	genetic	1	1	1	Negative Genetic
CYK3	YDL117W	SH3-domain protein located in the bud neck and cytokinetic actin ring	genetic	1	1	1	Negative Genetic
DNF1	YER166W	Aminophospholipid translocase (flippase)	physical	1	1	1	PCA
RPL43A	YPR043W	Ribosomal 60S subunit protein L43A	genetic	1	1	1	Negative Genetic
PUF2	YPR042C	PUF family mRNA-binding protein	physical	1	1	1	Affinity Capture-RNA
SCD6	YPR129W	Repressor of translation initiation	genetic	1	1	1	Phenotypic Suppression
EOS1	YNL080C	Protein involved in N-glycosylation	genetic	1	1	1	Negative Genetic
RIF2	YLR453C	Protein that binds to the Rap1p C-terminus	genetic	1	1	1	Negative Genetic
ENA1	YDR040C	P-type ATPase sodium pump	genetic	1	1	1	Positive Genetic
COS7	YDL248W	Endosomal protein involved in turnover of plasma membrane proteins	genetic	1	1	1	Negative Genetic
CHO2	YGR157W	Phosphatidylethanolamine methyltransferase (PEMT)	genetic	1	1	1	Negative Genetic
ERG3	YLR056W	C-5 sterol desaturase	genetic	1	1	1	Negative Genetic
ALK1	YGL021W	Atypical protein kinase	genetic	1	1	1	Phenotypic Suppression
CBP4	YGR174C	Mitochondrial protein required for assembly of cytochrome bc1 complex	genetic	1	1	1	Negative Genetic
COS5	YJR161C	Endosomal protein involved in turnover of plasma membrane proteins	genetic	1	1	1	Negative Genetic
PIC2	YER053C	Mitochondrial copper and phosphate carrier	genetic	1	1	1	Positive Genetic
ALK2	YBL009W	Atypical protein kinase	genetic	1	1	1	Phenotypic Suppression
MET22	YOL064C	Bisphosphate-3'-nucleotidase	genetic	1	1	1	Negative Genetic
MSC6	YOR354C	Multicopy suppressor of HER2 involved in mitochondrial translation	genetic	1	1	1	Negative Genetic
PDE2	YOR360C	High-affinity cyclic AMP phosphodiesterase	genetic	1	1	1	Negative Genetic
QRI7	YDL104C	Protein involved in threonylcarbamoyl adenosine biosynthesis	genetic	1	1	1	Negative Genetic
KCH1	YJR054W	Potassium transporter that mediates K+ influx	genetic	1	1	1	Negative Genetic