Standard name Systematic name Name description Description
ALK2 YBL009W Atypical protein kinase Atypical protein kinase; along with its paralog, ALK1, required for proper spindle positioning and nuclear segregation following mitotic arrest, proper organization of formins and polarisome components in mitosis, and survival after spindle assembly checkpoint delay; negatively regulates the morphogenesis checkpoint in response to polarity insults in opposition to ALK1; phosphorylated in response to DNA damage; similar to mammalian haspins
Visualize the interactome of ALK2
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
S 72

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
ALK2 0 1 0 1 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
YMC1 YPR058W Secondary mitochondrial inner membrane glycine transporter genetic 3 2 2 Dosage Growth Defect, Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
CHL1 YPL008W Probable DNA helicase genetic 2 1 2 Negative Genetic, Negative Genetic
IME1 YJR094C Master regulator of meiosis that is active only during meiotic events genetic 2 1 2 Negative Genetic, Negative Genetic
MRI1 YPR118W 5'-methylthioribose-1-phosphate isomerase genetic 2 1 2 Negative Genetic, Negative Genetic
SST2 YLR452C GTPase-activating protein for Gpa1p genetic 2 1 2 Negative Genetic, Negative Genetic
BRR1 YPR057W snRNP protein component of spliceosomal snRNPs genetic 2 1 2 Negative Genetic, Negative Genetic
MEH1 YKR007W Subunit of the EGO/GSE complex genetic 2 1 2 Negative Genetic, Negative Genetic
HMI1 YOL095C Mitochondrial inner membrane localized ATP-dependent DNA helicase genetic 2 1 2 Negative Genetic, Negative Genetic
YIL161W YIL161W Putative protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
RIM11 YMR139W Protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
TLG2 YOL018C Syntaxin-like t-SNARE genetic 2 1 2 Negative Genetic, Negative Genetic
RCK2 YLR248W Protein kinase involved in response to oxidative and osmotic stress genetic 2 1 2 Negative Genetic, Negative Genetic
MDL2 YPL270W Mitochondrial inner membrane half-type ABC transporter genetic 2 1 2 Negative Genetic, Negative Genetic
BEM3 YPL115C Rho GTPase activating protein (RhoGAP) genetic 2 1 2 Negative Genetic, Negative Genetic
GEM1 YAL048C Outer mitochondrial membrane GTPase, subunit of the ERMES complex genetic 2 1 2 Negative Genetic, Negative Genetic
SDH9 YJL045W Minor succinate dehydrogenase isozyme genetic 2 1 2 Negative Genetic, Negative Genetic
YOL036W YOL036W Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
PSO2 YMR137C Nuclease required for DNA single- and double-strand break repair genetic 2 1 2 Negative Genetic, Negative Genetic
PHO81 YGR233C Cyclin-dependent kinase (CDK) inhibitor genetic 2 1 2 Negative Genetic, Negative Genetic
OST5 YGL226C-A Zeta subunit of the oligosaccharyltransferase complex of the ER lumen genetic 2 1 2 Negative Genetic, Negative Genetic
MGP12 YDR286C Mitochondrial protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
DCV1 YFR012W Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
YMR206W YMR206W Putative protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
VPS17 YOR132W Subunit of the membrane-associated retromer complex genetic 2 1 2 Negative Genetic, Negative Genetic
ROG1 YGL144C Lipase with specificity for monoacylglycerol genetic 2 1 2 Negative Genetic, Negative Genetic
RGM1 YMR182C Putative zinc finger DNA binding transcription factor genetic 2 1 2 Negative Genetic, Negative Genetic
TPS3 YMR261C Regulatory subunit of trehalose-6-phosphate synthase/phosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
FRM2 YCL026C-A Type II nitroreductase, using NADH as reductant genetic 2 1 2 Negative Genetic, Negative Genetic
GAS2 YLR343W 1,3-beta-glucanosyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
SGM1 YJR134C Protein of unknown function genetic 2 1 2 Positive Genetic, Positive Genetic
SRP40 YKR092C Nucleolar serine-rich protein genetic 2 1 2 Positive Genetic, Positive Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 2 1 2 Positive Genetic, Positive Genetic
YMR226C YMR226C NADP(+)-dependent serine dehydrogenase and carbonyl reductase genetic 2 1 2 Positive Genetic, Positive Genetic
GLO1 YML004C Monomeric glyoxalase I genetic 2 1 2 Positive Genetic, Positive Genetic
PUN1 YLR414C Plasma membrane protein with a role in cell wall integrity genetic 2 1 2 Positive Genetic, Positive Genetic
FSH3 YOR280C Putative serine hydrolase genetic 2 1 2 Positive Genetic, Positive Genetic
MRX19 YDL183C Protein that may form an active mitochondrial KHE system genetic 2 1 2 Positive Genetic, Positive Genetic
YDR444W YDR444W Putative hydrolase acting on ester bonds genetic 2 1 2 Positive Genetic, Positive Genetic
YOR131C YOR131C Putative haloacid dehalogenase-like hydrolase genetic 2 1 2 Positive Genetic, Positive Genetic
ALK1 YGL021W Atypical protein kinase genetic 2 2 1 Synthetic Growth Defect, Phenotypic Suppression
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 2 1 1 Dosage Lethality, Dosage Lethality
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
ADE4 YMR300C Phosphoribosylpyrophosphate amidotransferase (PRPPAT) genetic 1 1 1 Negative Genetic
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex genetic 1 1 1 Negative Genetic
AIM22 YJL046W Lipoate-protein ligase genetic 1 1 1 Negative Genetic
BEM2 YER155C Rho GTPase activating protein (RhoGAP) physical 1 1 1 Affinity Capture-MS
KIN4 YOR233W Serine/threonine protein kinase physical 1 1 1 Affinity Capture-MS
LSM12 YHR121W Protein of unknown function that may function in RNA processing physical 1 1 1 Affinity Capture-MS
NOP12 YOL041C Nucleolar protein involved in pre-25S rRNA processing physical 1 1 1 Affinity Capture-MS
PBP4 YDL053C Pbp1p binding protein physical 1 1 1 Affinity Capture-MS
PET127 YOR017W Protein with a role in 5'-end processing of mitochondrial RNAs physical 1 1 1 Affinity Capture-MS
PWP1 YLR196W Protein with WD-40 repeats involved in rRNA processing physical 1 1 1 Affinity Capture-MS
TOR2 YKL203C PIK-related protein kinase and rapamycin target physical 1 1 1 Affinity Capture-MS
UTP22 YGR090W Component of the small-subunit processome physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
SLT2 YHR030C Serine/threonine MAP kinase physical 1 1 1 PCA
BEM1 YBR200W Protein containing SH3-domains genetic 1 1 1 Positive Genetic
SIT4 YDL047W Ceramide-activated, type 2A-related serine-threonine phosphatase genetic 1 1 1 Positive Genetic
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Positive Genetic
STE20 YHL007C Cdc42p-activated signal transducing kinase genetic 1 1 1 Positive Genetic
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Positive Genetic
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Positive Genetic
TMS1 YDR105C Vacuolar membrane protein of unknown function genetic 1 1 1 Negative Genetic
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
TAF8 YML114C TFIID subunit (65 kDa) genetic 1 1 1 Negative Genetic
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Dosage Lethality
EAF5 YEL018W Non-essential subunit of the NuA4 acetyltransferase complex genetic 1 1 1 Dosage Lethality
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 1 1 1 Dosage Growth Defect
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Dosage Growth Defect
NSI1 YDR026C RNA polymerase I termination factor genetic 1 1 1 Dosage Growth Defect
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 1 1 1 Dosage Growth Defect
YRF1-1 YDR545W Helicase encoded by the Y' element of subtelomeric regions genetic 1 1 1 Dosage Growth Defect
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin genetic 1 1 1 Dosage Growth Defect
NAB6 YML117W Putative RNA-binding protein genetic 1 1 1 Dosage Growth Defect
EFT1 YOR133W Elongation factor 2 (EF-2), also encoded by EFT2 genetic 1 1 1 Dosage Growth Defect
BOS1 YLR078C v-SNARE (vesicle specific SNAP receptor) genetic 1 1 1 Dosage Growth Defect
SGT1 YOR057W Cochaperone protein genetic 1 1 1 Dosage Growth Defect
SMA2 YML066C Meiosis-specific prospore membrane protein genetic 1 1 1 Negative Genetic
TCB1 YOR086C Lipid-binding ER protein involved in ER-plasma membrane tethering genetic 1 1 1 Negative Genetic
BNA5 YLR231C Kynureninase genetic 1 1 1 Negative Genetic
YML003W YML003W Putative protein of unknown function genetic 1 1 1 Negative Genetic
RLM1 YPL089C MADS-box transcription factor genetic 1 1 1 Negative Genetic
POM33 YLL023C Transmembrane nucleoporin genetic 1 1 1 Negative Genetic
YPL034W YPL034W Putative protein of unknown function genetic 1 1 1 Negative Genetic
PHO84 YML123C High-affinity inorganic phosphate (Pi) transporter genetic 1 1 1 Negative Genetic
RNH201 YNL072W Ribonuclease H2 catalytic subunit genetic 1 1 1 Negative Genetic
DID2 YKR035W-A Class E protein of the vacuolar protein-sorting (Vps) pathway genetic 1 1 1 Negative Genetic
MTD1 YKR080W NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase genetic 1 1 1 Negative Genetic
BUD7 YOR299W Member of the ChAPs family (Chs5p-Arf1p-binding proteins) genetic 1 1 1 Negative Genetic
RPS22B YLR367W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
ALY2 YJL084C Alpha arrestin, Ub-ligase adaptor for Rsp5p genetic 1 1 1 Negative Genetic
MDM35 YKL053C-A Mitochondrial intermembrane space protein genetic 1 1 1 Negative Genetic
ZRT3 YKL175W Vacuolar membrane zinc transporter genetic 1 1 1 Negative Genetic
DBP7 YKR024C Putative ATP-dependent RNA helicase of the DEAD-box family genetic 1 1 1 Negative Genetic
RED1 YLR263W Protein component of the synaptonemal complex axial elements genetic 1 1 1 Negative Genetic
YIR042C YIR042C Putative protein of unknown function genetic 1 1 1 Negative Genetic
KTR1 YOR099W Alpha-1,2-mannosyltransferase genetic 1 1 1 Negative Genetic
YBR220C YBR220C Putative protein of unknown function genetic 1 1 1 Negative Genetic
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex genetic 1 1 1 Negative Genetic
ATG26 YLR189C UDP-glucose:sterol glucosyltransferase genetic 1 1 1 Negative Genetic
VPS501 YKR078W Vacuolar SNX-BAR protein genetic 1 1 1 Negative Genetic
GMH1 YKR030W Golgi membrane protein of unknown function genetic 1 1 1 Negative Genetic
RDR1 YOR380W Transcriptional repressor involved in regulating multidrug resistance genetic 1 1 1 Negative Genetic
YKL050C YKL050C Protein of unknown function genetic 1 1 1 Negative Genetic
GEP7 YGL057C Protein of unknown function genetic 1 1 1 Negative Genetic
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 1 1 1 Negative Genetic
SIL1 YOL031C Nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p genetic 1 1 1 Negative Genetic
YML002W YML002W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YPL257W YPL257W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YIR043C YIR043C Blocked reading frame genetic 1 1 1 Negative Genetic
PHO91 YNR013C Low-affinity vacuolar phosphate transporter genetic 1 1 1 Negative Genetic
RIF1 YBR275C Protein involved in control of DNA replication genetic 1 1 1 Negative Genetic
MDM36 YPR083W Mitochondrial protein genetic 1 1 1 Negative Genetic
NRG2 YBR066C Transcriptional repressor genetic 1 1 1 Negative Genetic
VID28 YIL017C GID Complex subunit, serves as adaptor for regulatory subunit Vid24p genetic 1 1 1 Negative Genetic
YJR096W YJR096W Xylose and arabinose reductase genetic 1 1 1 Negative Genetic
AZF1 YOR113W Zinc-finger transcription factor genetic 1 1 1 Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Negative Genetic
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 1 1 1 Negative Genetic
SAM37 YMR060C Component of the Sorting and Assembly Machinery (SAM) complex genetic 1 1 1 Negative Genetic
KEL2 YGR238C Protein that negatively regulates mitotic exit genetic 1 1 1 Negative Genetic
CCP1 YKR066C Mitochondrial cytochrome-c peroxidase genetic 1 1 1 Negative Genetic
SAP185 YJL098W Protein that forms a complex with the Sit4p protein phosphatase genetic 1 1 1 Negative Genetic
YSP2 YDR326C Sterol-binding protein genetic 1 1 1 Negative Genetic
PES4 YFR023W Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation genetic 1 1 1 Negative Genetic
CAM1 YPL048W One of two isoforms of the gamma subunit of eEF1B genetic 1 1 1 Negative Genetic
HPM1 YIL110W AdoMet-dependent methyltransferase genetic 1 1 1 Negative Genetic
PHR1 YOR386W DNA photolyase involved in photoreactivation genetic 1 1 1 Positive Genetic
YJL213W YJL213W Protein of unknown function that may interact with ribosomes genetic 1 1 1 Positive Genetic
PXA1 YPL147W Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p genetic 1 1 1 Positive Genetic
GNT1 YOR320C N-acetylglucosaminyltransferase genetic 1 1 1 Positive Genetic
YPR096C YPR096C Protein of unknown function genetic 1 1 1 Positive Genetic
HSP104 YLL026W Disaggregase genetic 1 1 1 Positive Genetic
ECM7 YLR443W Putative integral membrane protein with a role in calcium uptake genetic 1 1 1 Positive Genetic
IOC2 YLR095C Subunit of the Isw1b complex genetic 1 1 1 Positive Genetic
SPO20 YMR017W Meiosis-specific subunit of the t-SNARE complex genetic 1 1 1 Positive Genetic
GAC1 YOR178C Regulatory subunit for Glc7p type-1 protein phosphatase (PP1) genetic 1 1 1 Positive Genetic
RCI37 YIL077C Protein that associates with the large mitoribosomal subunit genetic 1 1 1 Positive Genetic
HCR1 YLR192C eIF3j component of translation initiation factor 3 (eIF3) genetic 1 1 1 Positive Genetic
FMP42 YMR221C Putative protein of unknown function genetic 1 1 1 Positive Genetic
FET4 YMR319C Low-affinity Fe(II) transporter of the plasma membrane genetic 1 1 1 Positive Genetic
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE genetic 1 1 1 Positive Genetic
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Positive Genetic
CIR1 YGR207C Mitochondrial protein that interacts with frataxin (Yfh1p) genetic 1 1 1 Positive Genetic
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
SUP35 YDR172W Translation termination factor eRF3 genetic 1 1 1 Negative Genetic
YTH1 YPR107C Essential RNA-binding component of cleavage and polyadenylation factor genetic 1 1 1 Negative Genetic
PAU7 YAR020C Member of the seripauperin multigene family genetic 1 1 1 Negative Genetic
RBK1 YCR036W Ribokinase, phosphorylates ribose to ribose-5-phosphate genetic 1 1 1 Negative Genetic
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Negative Genetic
INH1 YDL181W Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase genetic 1 1 1 Negative Genetic
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Negative Genetic
RPS24A YER074W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism genetic 1 1 1 Negative Genetic
RAD4 YER162C Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 genetic 1 1 1 Negative Genetic
YGL036W YGL036W Putative protein of unknown function genetic 1 1 1 Negative Genetic
ENO1 YGR254W Enolase I, a phosphopyruvate hydratase genetic 1 1 1 Negative Genetic
NAM8 YHR086W RNA binding protein, component of the U1 snRNP protein genetic 1 1 1 Negative Genetic
QDR1 YIL120W Multidrug transporter of the major facilitator superfamily genetic 1 1 1 Negative Genetic
IME2 YJL106W Serine/threonine protein kinase involved in activation of meiosis genetic 1 1 1 Negative Genetic
RAV1 YJR033C Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) genetic 1 1 1 Negative Genetic
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p genetic 1 1 1 Negative Genetic
YJR084W YJR084W Protein that forms a complex with Thp3p genetic 1 1 1 Negative Genetic
GTT2 YLL060C Glutathione S-transferase capable of homodimerization genetic 1 1 1 Negative Genetic
RIM9 YMR063W Plasma membrane protein of unknown function genetic 1 1 1 Negative Genetic
ERG2 YMR202W C-8 sterol isomerase genetic 1 1 1 Negative Genetic
TRI1 YMR233W Non-essential sumoylated protein of unknown function genetic 1 1 1 Negative Genetic
PET494 YNR045W Mitochondrial translational activator specific for the COX3 mRNA genetic 1 1 1 Negative Genetic
SLK19 YOR195W Kinetochore-associated protein genetic 1 1 1 Negative Genetic
VPH1 YOR270C Subunit a of the vacuolar-ATPase V0 domain genetic 1 1 1 Negative Genetic
MUM3 YOR298W Protein of unknown function involved in outer spore wall organization genetic 1 1 1 Negative Genetic
RMI1 YPL024W Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex genetic 1 1 1 Negative Genetic
YPR015C YPR015C Putative zinc finger transcription factor genetic 1 1 1 Negative Genetic
NCA2 YPR155C Protein that regulates expression of Fo-F1 ATP synthase subunits genetic 1 1 1 Negative Genetic
OPT2 YPR194C Oligopeptide transporter genetic 1 1 1 Negative Genetic
MRPL27 YBR282W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
OST4 YDL232W Subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Negative Genetic
MFB1 YDR219C Mitochondria-associated F-box protein genetic 1 1 1 Negative Genetic
URH1 YDR400W Uridine nucleosidase (uridine-cytidine N-ribohydrolase) genetic 1 1 1 Negative Genetic
YHR050W-A YHR050W-A Protein of unknown function genetic 1 1 1 Negative Genetic
LHS1 YKL073W Molecular chaperone of the endoplasmic reticulum lumen genetic 1 1 1 Negative Genetic
YML020W YML020W Putative protein of unknown function genetic 1 1 1 Negative Genetic
VAC7 YNL054W Integral vacuolar membrane protein genetic 1 1 1 Negative Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Negative Genetic
MRPL17 YNL252C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
RSM19 YNR037C Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Negative Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Negative Genetic
BCY1 YIL033C Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) genetic 1 1 1 Phenotypic Suppression
RAS1 YOR101W GTPase involved in G-protein signaling in adenylate cyclase activation genetic 1 1 1 Phenotypic Suppression
RAS2 YNL098C GTP-binding protein genetic 1 1 1 Phenotypic Suppression
SEC6 YIL068C Essential 88kDa subunit of the exocyst complex genetic 1 1 1 Phenotypic Suppression
AGP3 YFL055W Low-affinity amino acid permease genetic 1 1 1 Negative Genetic