Standard name Systematic name Name description Description
RIF1 YBR275C Protein involved in control of DNA replication Protein involved in control of DNA replication; binds Rap1p C-terminus, telomeres, centromeres, replication origins; contributes to resection of DNA double strand breaks (DSBs); acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; in addition to controlling DNA replication initiation, plays ongoing role after initiation and controls events at blocked replication forks
Visualize the interactome of RIF1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1/S 50

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.116 0.136 0.427
Endosome 0.477 0.258 0.105
Mito 0.075 0.315 0.344
Nuc Periphery 0.075 NaN NaN
Nucleus 0.050 NaN NaN
SpindlePole 0.236 0.061 0.170
Vac/Vac Memb 0.221 0.390 NaN

GFP localization & abundance

GFP localization GFP abundance
nucleus low signal

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
RIF1 3 0 0 0 4

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
RIF2 YLR453C Protein that binds to the Rap1p C-terminus genetic 10 2 8 Phenotypic Enhancement, Dosage Rescue, Dosage Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci physical 10 4 7 Two-hybrid, Two-hybrid, Two-hybrid, Co-crystal Structure, Two-hybrid, Reconstituted Complex, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Two-hybrid
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 9 4 7 Synthetic Rescue, Synthetic Lethality, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Positive Genetic, Synthetic Rescue
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 7 5 3 Phenotypic Suppression, Synthetic Rescue, Synthetic Growth Defect, Dosage Rescue, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 6 4 6 Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 5 4 5 Phenotypic Enhancement, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 5 4 5 Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Rescue
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit physical 4 3 4 Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 4 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Suppression
HTA1 YDR225W Histone H2A genetic 4 3 3 Negative Genetic, Phenotypic Enhancement, Phenotypic Suppression, Negative Genetic
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 4 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 4 2 3 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 4 2 3 Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue
HHF1 YBR009C Histone H4 genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 3 3 3 Negative Genetic, Synthetic Lethality, Synthetic Rescue
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation genetic 3 2 3 Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
HHT1 YBR010W Histone H3 genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
STN1 YDR082W Telomere end-binding and capping protein genetic 3 2 2 Synthetic Lethality, Negative Genetic, Negative Genetic
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) genetic 2 2 2 Phenotypic Suppression, Phenotypic Enhancement
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 2 2 2 Negative Genetic, Phenotypic Suppression
CTF4 YPR135W Chromatin-associated protein genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
DPB11 YJL090C DNA replication initiation protein genetic 2 2 2 Positive Genetic, Synthetic Rescue
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 2 2 2 Synthetic Rescue, Phenotypic Suppression
PRI2 YKL045W Subunit of DNA primase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 2 1 2 Negative Genetic, Negative Genetic
CDC14 YFR028C Protein phosphatase required for mitotic exit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 2 1 2 Negative Genetic, Negative Genetic
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 2 1 2 Negative Genetic, Negative Genetic
RIF1 YBR275C Protein involved in control of DNA replication physical 2 1 2 Co-crystal Structure, Co-crystal Structure
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex physical 2 1 2 Two-hybrid, Two-hybrid
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase genetic 2 1 2 Phenotypic Suppression, Phenotypic Suppression
PFA4 YOL003C Palmitoyltransferase with autoacylation activity regulation 2 2 1 mass spectrometry evidence, qualitative western immunoblotting evidence
FOB1 YDR110W Nucleolar protein that binds the rDNA replication fork barrier site genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
SAE2 YGL175C Endonuclease required for telomere elongation genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
ELP3 YPL086C Subunit of Elongator complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit regulation 1 1 1 quantitative mass spectrometry evidence
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 1 1 1 Phenotypic Suppression
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Phenotypic Suppression
RAT1 YOR048C Nuclear 5' to 3' single-stranded RNA exonuclease genetic 1 1 1 Phenotypic Enhancement
HPR1 YDR138W Subunit of THO/TREX complexes genetic 1 1 1 Phenotypic Suppression
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-MS
AOS1 YPR180W Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Uba2p genetic 1 1 1 Negative Genetic
ARO1 YDR127W Pentafunctional arom protein genetic 1 1 1 Positive Genetic
CDC45 YLR103C DNA replication initiation factor genetic 1 1 1 Synthetic Rescue
HHF1 YBR009C Histone H4 physical 1 1 1 Affinity Capture-MS
HHF2 YNL030W Histone H4 physical 1 1 1 Affinity Capture-MS
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
MAK3 YPR051W Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT) genetic 1 1 1 Negative Genetic
MCD1 YDL003W Essential alpha-kleisin subunit of the cohesin complex genetic 1 1 1 Phenotypic Enhancement
GAL11 YOL051W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Rescue
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
HTZ1 YOL012C Histone variant H2AZ physical 1 1 1 Affinity Capture-MS
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Synthetic Rescue
HTA1 YDR225W Histone H2A physical 1 1 1 Affinity Capture-MS
HTA2 YBL003C Histone H2A physical 1 1 1 Affinity Capture-MS
NOC4 YPR144C Nucleolar protein physical 1 1 1 Affinity Capture-MS
RAD3 YER171W 5' to 3' DNA helicase genetic 1 1 1 Negative Genetic
REF2 YDR195W RNA-binding protein genetic 1 1 1 Negative Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
MKS1 YNL076W Pleiotropic negative transcriptional regulator genetic 1 1 1 Negative Genetic
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Negative Genetic
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
HTB1 YDR224C Histone H2B genetic 1 1 1 Phenotypic Suppression
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 1 1 1 Phenotypic Enhancement
RAD24 YER173W Checkpoint protein genetic 1 1 1 Synthetic Rescue
HHT1 YBR010W Histone H3 physical 1 1 1 Affinity Capture-MS
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 1 1 1 Negative Genetic
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 1 1 1 Negative Genetic
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) physical 1 1 1 Reconstituted Complex
CSM3 YMR048W Replication fork associated factor genetic 1 1 1 Synthetic Rescue
RFT1 YBL020W Membrane protein required for translocation of Man5GlcNac2-PP-Dol genetic 1 1 1 Negative Genetic
NFI1 YOR156C SUMO E3 ligase genetic 1 1 1 Phenotypic Enhancement
RIF2 YLR453C Protein that binds to the Rap1p C-terminus physical 1 1 1 Affinity Capture-MS
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family physical 1 1 1 Affinity Capture-MS
RNH201 YNL072W Ribonuclease H2 catalytic subunit physical 1 1 1 Affinity Capture-Western
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes physical 1 1 1 Affinity Capture-Western
SEC61 YLR378C Conserved ER protein translocation channel physical 1 1 1 Affinity Capture-MS
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 1 1 1 Synthetic Rescue
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism genetic 1 1 1 Synthetic Rescue
RPC40 YPR110C RNA polymerase subunit AC40 genetic 1 1 1 Negative Genetic
SSL1 YLR005W Subunit of the core form of RNA polymerase transcription factor TFIIH genetic 1 1 1 Negative Genetic
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
RSC6 YCR052W Component of the RSC chromatin remodeling complex genetic 1 1 1 Positive Genetic
SUA5 YGL169W Protein involved in threonylcarbamoyl adenosine biosynthesis genetic 1 1 1 Phenotypic Suppression
VID24 YBR105C GID Complex regulatory subunit genetic 1 1 1 Negative Genetic
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Synthetic Growth Defect
VOA1 YGR106C ER protein that functions in assembly of the V0 sector of V-ATPase genetic 1 1 1 Synthetic Growth Defect
THO2 YNL139C Subunit of the THO complex genetic 1 1 1 Phenotypic Suppression
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Phenotypic Enhancement
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 1 1 1 Synthetic Growth Defect
UBP13 YBL067C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Positive Genetic
RPL28 YGL103W Ribosomal 60S subunit protein L28 genetic 1 1 1 Negative Genetic
SMD2 YLR275W Core Sm protein Sm D2 genetic 1 1 1 Negative Genetic
SMX3 YPR182W Core Sm protein Sm F genetic 1 1 1 Negative Genetic
SNF6 YHL025W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
SDH9 YJL045W Minor succinate dehydrogenase isozyme genetic 1 1 1 Negative Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Negative Genetic
UPS1 YLR193C Phosphatidic acid transfer protein genetic 1 1 1 Negative Genetic
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
VPS21 YOR089C Endosomal Rab family GTPase genetic 1 1 1 Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Negative Genetic
YHR050W-A YHR050W-A Protein of unknown function genetic 1 1 1 Negative Genetic
SAS2 YMR127C Histone acetyltransferase (HAT) catalytic subunit of the SAS complex genetic 1 1 1 Negative Genetic
RPL20B YOR312C Ribosomal 60S subunit protein L20B genetic 1 1 1 Negative Genetic
UBP10 YNL186W Ubiquitin-specific protease, deubiquitinates Ub-protein moieties genetic 1 1 1 Phenotypic Suppression
SLD3 YGL113W Protein involved in the initiation of DNA replication genetic 1 1 1 Synthetic Rescue
SPC105 YGL093W Subunit of a kinetochore-microtubule binding complex genetic 1 1 1 Negative Genetic
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Synthetic Rescue
MEX67 YPL169C Poly(A)RNA binding protein involved in nuclear mRNA export physical 1 1 1 Affinity Capture-MS
NUP170 YBL079W Subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Phenotypic Suppression
MET28 YIR017C bZIP transcriptional activator in the Cbf1p-Met4p-Met28p complex genetic 1 1 1 Negative Genetic
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p physical 1 1 1 Affinity Capture-MS
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 1 1 1 Phenotypic Suppression
HHT2 YNL031C Histone H3 physical 1 1 1 Affinity Capture-MS
NDJ1 YOL104C Protein that regulates meiotic SPB cohesion and telomere clustering physical 1 1 1 Affinity Capture-MS
ORC4 YPR162C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Phenotypic Enhancement
BYE1 YKL005C Negative regulator of transcription elongation physical 1 1 1 Affinity Capture-MS
BYE1 YKL005C Negative regulator of transcription elongation genetic 1 1 1 Negative Genetic
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 1 1 1 Negative Genetic
NAM2 YLR382C Mitochondrial leucyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
PTP1 YDL230W Phosphotyrosine-specific protein phosphatase physical 1 1 1 Affinity Capture-MS
PSR2 YLR019W Putative plasma membrane phosphatase physical 1 1 1 Affinity Capture-MS
FRM2 YCL026C-A Type II nitroreductase, using NADH as reductant genetic 1 1 1 Negative Genetic
MRX6 YNL295W Mitochondrial ribosome-associated protein genetic 1 1 1 Negative Genetic
MRK1 YDL079C Glycogen synthase kinase 3 (GSK-3) homolog genetic 1 1 1 Negative Genetic
MRM2 YGL136C Mitochondrial 2' O-ribose methyltransferase genetic 1 1 1 Positive Genetic
ALK2 YBL009W Atypical protein kinase genetic 1 1 1 Negative Genetic