THO2 |
YNL139C |
Subunit of the THO complex |
physical |
18 |
4 |
14 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-crystal Structure, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western |
MFT1 |
YML062C |
Subunit of the THO complex |
physical |
14 |
2 |
12 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western |
THP2 |
YHR167W |
Subunit of the THO and TREX complexes |
physical |
13 |
2 |
10 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
SUB2 |
YDL084W |
Component of the TREX complex required for nuclear mRNA export |
physical |
13 |
4 |
9 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western |
SUB2 |
YDL084W |
Component of the TREX complex required for nuclear mRNA export |
genetic |
10 |
2 |
8 |
Dosage Rescue, Dosage Rescue, Dosage Rescue, Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Synthetic Lethality, Dosage Rescue, Dosage Rescue |
GBP2 |
YCL011C |
Poly(A+) RNA-binding protein |
physical |
9 |
2 |
6 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western |
MEX67 |
YPL169C |
Poly(A)RNA binding protein involved in nuclear mRNA export |
physical |
9 |
5 |
4 |
Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Reconstituted Complex, FRET, Affinity Capture-MS |
RNH1 |
YMR234W |
Ribonuclease H1 |
genetic |
6 |
2 |
6 |
Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression |
YRA1 |
YDR381W |
Nuclear polyadenylated RNA-binding protein |
physical |
6 |
3 |
5 |
Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
TOP1 |
YOL006C |
Topoisomerase I |
genetic |
5 |
3 |
5 |
Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement |
HRB1 |
YNL004W |
Poly(A+) RNA-binding protein |
physical |
5 |
1 |
3 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
TEX1 |
YNL253W |
Protein involved in mRNA export |
physical |
4 |
2 |
4 |
Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western |
CBC2 |
YPL178W |
Small subunit of the heterodimeric cap binding complex with Sto1p |
physical |
4 |
2 |
3 |
Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western |
YRA1 |
YDR381W |
Nuclear polyadenylated RNA-binding protein |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Dosage Growth Defect |
SOH1 |
YGL127C |
Subunit of the RNA polymerase II mediator complex |
genetic |
3 |
2 |
3 |
Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue |
HHT1 |
YBR010W |
Histone H3 |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Phenotypic Suppression, Phenotypic Suppression |
RRP6 |
YOR001W |
Nuclear exosome exonuclease component |
genetic |
3 |
3 |
2 |
Synthetic Growth Defect, Synthetic Rescue, Phenotypic Suppression |
RSP5 |
YER125W |
NEDD4 family E3 ubiquitin ligase |
physical |
3 |
2 |
2 |
Reconstituted Complex, Reconstituted Complex, Biochemical Activity |
SRB2 |
YHR041C |
Subunit of the RNA polymerase II mediator complex |
genetic |
3 |
2 |
2 |
Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue |
PAF1 |
YBR279W |
Component of the Paf1p complex involved in transcription elongation |
physical |
3 |
1 |
2 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
THO2 |
YNL139C |
Subunit of the THO complex |
genetic |
2 |
2 |
2 |
Dosage Rescue, Synthetic Growth Defect |
STO1 |
YMR125W |
Large subunit of the nuclear mRNA cap-binding protein complex |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Affinity Capture-Western |
NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
2 |
2 |
2 |
Affinity Capture-RNA, Affinity Capture-MS |
PAP2 |
YOL115W |
Non-canonical poly(A) polymerase |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
PGD1 |
YGL025C |
Subunit of the RNA polymerase II mediator complex |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Phenotypic Suppression |
SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Synthetic Growth Defect |
RAD7 |
YJR052W |
Nucleotide excision repair (NER) protein |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Synthetic Growth Defect |
RNH201 |
YNL072W |
Ribonuclease H2 catalytic subunit |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Synthetic Rescue |
MEC1 |
YBR136W |
Genome integrity checkpoint protein and PI kinase superfamily member |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Synthetic Rescue |
RAD53 |
YPL153C |
DNA damage response kinase |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Synthetic Rescue |
DST1 |
YGL043W |
General transcription elongation factor TFIIS |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Negative Genetic |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
2 |
2 |
2 |
Affinity Capture-Western, Affinity Capture-RNA |
HHF1 |
YBR009C |
Histone H4 |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Phenotypic Suppression |
SWT1 |
YOR166C |
RNA endoribonuclease involved in perinuclear mRNP quality control |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
THO1 |
YER063W |
Conserved nuclear RNA-binding protein |
genetic |
2 |
1 |
2 |
Dosage Rescue, Dosage Rescue |
SYF1 |
YDR416W |
Member of the NineTeen Complex (NTC) |
physical |
2 |
2 |
1 |
Affinity Capture-Western, Affinity Capture-MS |
MEC3 |
YLR288C |
DNA damage and meiotic pachytene checkpoint protein |
genetic |
2 |
2 |
1 |
Synthetic Lethality, Synthetic Growth Defect |
RAD24 |
YER173W |
Checkpoint protein |
genetic |
2 |
2 |
1 |
Synthetic Lethality, Synthetic Growth Defect |
SPT16 |
YGL207W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Phenotypic Enhancement |
POB3 |
YML069W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Phenotypic Enhancement |
DDC1 |
YPL194W |
DNA damage checkpoint protein |
genetic |
2 |
2 |
1 |
Synthetic Lethality, Synthetic Growth Defect |
SSB1 |
YDL229W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
2 |
1 |
1 |
Affinity Capture-MS, Affinity Capture-MS |
SRO9 |
YCL037C |
Cytoplasmic RNA-binding protein |
physical |
2 |
1 |
1 |
Affinity Capture-Western, Affinity Capture-Western |
GCN5 |
YGR252W |
Catalytic subunit of ADA and SAGA histone acetyltransferase complexes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
CDC73 |
YLR418C |
Component of the Paf1p complex |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
CDC73 |
YLR418C |
Component of the Paf1p complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CKA2 |
YOR061W |
Alpha' catalytic subunit of casein kinase 2 (CK2) |
genetic |
1 |
1 |
1 |
Positive Genetic |
HPR1 |
YDR138W |
Subunit of THO/TREX complexes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MFT1 |
YML062C |
Subunit of the THO complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SSK2 |
YNR031C |
MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PRB1 |
YEL060C |
Vacuolar proteinase B (yscB) with H3 N-terminal endopeptidase activity |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SWD3 |
YBR175W |
Essential subunit of the COMPASS (Set1C) complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SRP1 |
YNL189W |
Karyopherin alpha homolog |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PAF1 |
YBR279W |
Component of the Paf1p complex involved in transcription elongation |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
RPO21 |
YDL140C |
RNA polymerase II largest subunit B220 |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
RRP45 |
YDR280W |
Exosome non-catalytic core component |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
RRP6 |
YOR001W |
Nuclear exosome exonuclease component |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
YRA2 |
YKL214C |
Member of the REF (RNA and export factor binding proteins) family |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
RPB2 |
YOR151C |
RNA polymerase II second largest subunit B150 |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
RPB2 |
YOR151C |
RNA polymerase II second largest subunit B150 |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
TFG2 |
YGR005C |
TFIIF (Transcription Factor II) middle subunit |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
ULS1 |
YOR191W |
Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
IMD3 |
YLR432W |
Inosine monophosphate dehydrogenase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SWT1 |
YOR166C |
RNA endoribonuclease involved in perinuclear mRNP quality control |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
MEX67 |
YPL169C |
Poly(A)RNA binding protein involved in nuclear mRNA export |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
STO1 |
YMR125W |
Large subunit of the nuclear mRNA cap-binding protein complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SAC3 |
YDR159W |
mRNA export factor |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NNK1 |
YKL171W |
Protein kinase |
physical |
1 |
1 |
1 |
Two-hybrid |
PRP16 |
YKR086W |
DEAH-box RNA helicase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PRP22 |
YER013W |
DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPT6 |
YGL048C |
ATPase of the 19S regulatory particle of the 26S proteasome |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
SYF1 |
YDR416W |
Member of the NineTeen Complex (NTC) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
NAM7 |
YMR080C |
ATP-dependent RNA helicase of the SFI superfamily |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
MLP2 |
YIL149C |
Myosin-like protein associated with the nuclear envelope |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
MLP2 |
YIL149C |
Myosin-like protein associated with the nuclear envelope |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
VAM6 |
YDL077C |
Guanine nucleotide exchange factor for the GTPase Gtr1p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
RPC82 |
YPR190C |
RNA polymerase III subunit C82 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
PUB1 |
YNL016W |
Poly (A)+ RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SMC6 |
YLR383W |
Subunit of the SMC5-SMC6 complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS0A |
YGR214W |
Ribosomal 40S subunit protein S0A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS1A |
YLR441C |
Ribosomal protein of the small (40S) subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS2 |
YGL123W |
Protein component of the small (40S) subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS6A |
YPL090C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS8A |
YBL072C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS10A |
YOR293W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS12 |
YOR369C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS13 |
YDR064W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS15 |
YOL040C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS17A |
YML024W |
Ribosomal protein 51 (rp51) of the small (40s) subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS18A |
YDR450W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS19A |
YOL121C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS20 |
YHL015W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPL25 |
YOL127W |
Ribosomal 60S subunit protein L25 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPL26A |
YLR344W |
Ribosomal 60S subunit protein L26A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS27A |
YKL156W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPL31A |
YDL075W |
Ribosomal 60S subunit protein L31A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS3 |
YNL178W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS14A |
YCR031C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SIR3 |
YLR442C |
Silencing protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SRB5 |
YGR104C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SPT2 |
YER161C |
Protein involved in negative regulation of transcription |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SPT4 |
YGR063C |
Spt4p/5p (DSIF) transcription elongation factor complex subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SIN4 |
YNL236W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SUA7 |
YPR086W |
Transcription factor TFIIB |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SIR2 |
YDL042C |
Conserved NAD+ dependent histone deacetylase of the Sirtuin family |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
TOF2 |
YKR010C |
Protein required for rDNA silencing and mitotic rDNA condensation |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RAD16 |
YBR114W |
Nucleotide excision repair (NER) protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
RPB9 |
YGL070C |
RNA polymerase II subunit B12.6 |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
MLP1 |
YKR095W |
Myosin-like protein associated with the nuclear envelope |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RNH202 |
YDR279W |
Ribonuclease H2 subunit |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
RNH203 |
YLR154C |
Ribonuclease H2 subunit |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
RAD5 |
YLR032W |
DNA helicase/Ubiquitin ligase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
RAD52 |
YML032C |
Protein involved in homologous recombination |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SEH1 |
YGL100W |
Subunit of the Nup84 nuclear pore and SEACAT subcomplexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
TIF4632 |
YGL049C |
Translation initiation factor eIF4G and scaffold protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
MUD2 |
YKL074C |
Protein involved in early pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Negative Genetic |
NUP100 |
YKL068W |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
NGL2 |
YMR285C |
Protein involved in 5.8S rRNA processing |
genetic |
1 |
1 |
1 |
Negative Genetic |
LSM1 |
YJL124C |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
MOG1 |
YJR074W |
Conserved nuclear protein that interacts with GTP-Gsp1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
SAP30 |
YMR263W |
Component of Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
NOP56 |
YLR197W |
Essential evolutionarily-conserved nucleolar protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
TSR1 |
YDL060W |
Protein required for processing of 20S pre-rRNA in the cytoplasm |
genetic |
1 |
1 |
1 |
Positive Genetic |
WHI4 |
YDL224C |
Putative RNA binding protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
WHI3 |
YNL197C |
RNA binding protein that modulates mRNA stability |
genetic |
1 |
1 |
1 |
Positive Genetic |
SUP35 |
YDR172W |
Translation termination factor eRF3 |
genetic |
1 |
1 |
1 |
Positive Genetic |
LRS4 |
YDR439W |
Nucleolar protein that forms a complex with Csm1p |
genetic |
1 |
1 |
1 |
Positive Genetic |
POP8 |
YBL018C |
Subunit of both RNase MRP and nuclear RNase P |
genetic |
1 |
1 |
1 |
Positive Genetic |
NGR1 |
YBR212W |
RNA binding protein that negatively regulates growth rate |
genetic |
1 |
1 |
1 |
Positive Genetic |
UTP30 |
YKR060W |
Subunit of U3-containing 90S preribosome complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
IFM1 |
YOL023W |
Mitochondrial translation initiation factor 2 |
genetic |
1 |
1 |
1 |
Positive Genetic |
RAD9 |
YDR217C |
DNA damage-dependent checkpoint protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MRC1 |
YCL061C |
S-phase checkpoint protein required for DNA replication |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SML1 |
YML058W |
Ribonucleotide reductase inhibitor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MAD2 |
YJL030W |
Component of the spindle-assembly checkpoint complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SRC1 |
YML034W |
Inner nuclear membrane protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RAD17 |
YOR368W |
Checkpoint protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
POL32 |
YJR043C |
Third subunit of DNA polymerase delta |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
PRI1 |
YIR008C |
Subunit of DNA primase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
THP3 |
YPR045C |
Protein that may have a role in transcription elongation |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
SCH9 |
YHR205W |
AGC family protein kinase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
NUT2 |
YPR168W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
YJR084W |
YJR084W |
Protein that forms a complex with Thp3p |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RIF2 |
YLR453C |
Protein that binds to the Rap1p C-terminus |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
RIF1 |
YBR275C |
Protein involved in control of DNA replication |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
NPL3 |
YDR432W |
RNA-binding protein |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
TOP2 |
YNL088W |
Topoisomerase II |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
MPS3 |
YJL019W |
Nuclear envelope protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
UAF30 |
YOR295W |
Subunit of UAF (upstream activation factor) complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
RRN3 |
YKL125W |
Protein required for transcription of rDNA by RNA polymerase I |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
VPS4 |
YPR173C |
AAA-ATPase involved in multivesicular body (MVB) protein sorting |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SEN1 |
YLR430W |
ATP-dependent 5' to 3' RNA/DNA and DNA helicase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
ACC1 |
YNR016C |
Acetyl-CoA carboxylase, biotin containing enzyme |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
ASF1 |
YJL115W |
Nucleosome assembly factor |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ASC1 |
YMR116C |
G-protein beta subunit and guanine dissociation inhibitor for Gpa2p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CTF18 |
YMR078C |
Subunit of a complex with Ctf8p |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
CTK1 |
YKL139W |
Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
DNA2 |
YHR164C |
ATP-dependent 5'-flap endonuclease and DNA helicase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
GAL11 |
YOL051W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
AHA1 |
YDR214W |
Co-chaperone that binds Hsp82p and activates its ATPase activity |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CDC6 |
YJL194W |
Essential ATP-binding protein required for DNA replication |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
CAF20 |
YOR276W |
Phosphoprotein of the mRNA cap-binding complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
ATG17 |
YLR423C |
Scaffold protein responsible for phagophore assembly site organization |
physical |
1 |
1 |
1 |
Two-hybrid |
DIA2 |
YOR080W |
Origin-binding F-box protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
FPK1 |
YNR047W |
Ser/Thr protein kinase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ELG1 |
YOR144C |
Subunit of an alternative replication factor C complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
DEF1 |
YKL054C |
RNAPII degradation factor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
CAK1 |
YFL029C |
Cyclin-dependent kinase-activating kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
FOB1 |
YDR110W |
Nucleolar protein that binds the rDNA replication fork barrier site |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
ELP6 |
YMR312W |
Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex |
genetic |
1 |
1 |
1 |
Negative Genetic |
ELP3 |
YPL086C |
Subunit of Elongator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
CSE4 |
YKL049C |
Centromeric histone H3-like protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
GIM4 |
YEL003W |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
GAL80 |
YML051W |
Transcriptional regulator involved in the repression of GAL genes |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
CPR7 |
YJR032W |
Peptidyl-prolyl cis-trans isomerase (cyclophilin) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HHT2 |
YNL031C |
Histone H3 |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
DEG1 |
YFL001W |
tRNA:pseudouridine synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
APQ12 |
YIL040W |
Nuclear envelope/ER integral membrane protein |
genetic |
1 |
1 |
1 |
Positive Genetic |